CN103743721B - Phasmon strengthens Raman spectrum dynamic detection system - Google Patents
Phasmon strengthens Raman spectrum dynamic detection system Download PDFInfo
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- CN103743721B CN103743721B CN201410023821.7A CN201410023821A CN103743721B CN 103743721 B CN103743721 B CN 103743721B CN 201410023821 A CN201410023821 A CN 201410023821A CN 103743721 B CN103743721 B CN 103743721B
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Abstract
Phasmon strengthens Raman spectrum dynamic detection system, relates to Raman spectrum and detects.Be provided with support, spectrometer, light shield, guide rail, catoptron, catoptron lens barrel, upper motor, condenser, condenser lens barrel, CD shape sample cell, lower motor and control circuit; Spectrometer is fixed on rack platform, and catoptron lens barrel is arranged on guide rail, and catoptron lens barrel and condenser lens barrel utilize threaded engagement, and rotary condenser lens barrel regulates condenser from the distance between CD shape sample cell, reaches the object of focusing; Spectrometer is connected by scalable light shield with catoptron lens barrel; After the laser that spectrometer sends is reflected by catoptron, through converging on CD shape sample cell after condenser, catoptron lens barrel can along guide rail tangential movement under the control of upper motor, can carry out dynamic acquisition to the Raman signal that testing sample in the middle of microchannel on CD shape sample cell and Raman strengthen sample in mix particles, detachment process, control circuit is electrically connected with upper motor and lower motor.
Description
Technical field
The present invention relates to Raman spectrum to detect, especially relate to phasmon and strengthen Raman spectrum dynamic detection system.
Background technology
It is the Raman technology of a kind of advanced person that phasmon strengthens Raman spectrum, its principle be molecular adsorption near surface of metal particles, vibrational spectrum signal can obtain enhancing.Because it has highly sensitive, the simple feature of sample preparation, so phasmon enhancing Raman spectroscopy is extensively concerned, be considered to a kind of rich promising inspection technology.
Phasmon strengthens Raman spectroscopy and is widely used in various field, comprises biology, such as division bacteria, protein research and tumour cell identification etc.; Medical science pharmacy, such as immune detection, cell research; Material science, the such as research of CNT, polymkeric substance, self assembly molecular layer; Galvanochemistry, such as, detect the change of certain chemical substance value in redox reaction; Environmental monitoring, such as water pollutions monitoring, residual poison control centre detect; National security, such as trace explosive detects, detection of poison gas; Health monitoring, such as blood sugar, cholesterol detection etc.
Chinese patent CN102156114A proposes a kind of Raman detection method and system.The detection method of this invention comprises provides fluid determinand in a signal gain structure, and provides a LASER Light Source in this signal gain structure, and this structure has a V-groove can make the Raman signal of determinand amplify.This Dynamic System more complicated in actual applications, efficiency comparison is low.
Chinese patent CN101614667A proposes a kind of Raman spectrum system.This Raman spectrum system comprises inspection center, and this inspection center comprises at least one light source, for exporting the exciting light exciting checking matter to produce Raman diffused light; Analytical equipment, for obtaining the Raman spectrum of checking matter.Raman spectrum system also comprises at least one sense terminals, and each sense terminals comprises at least one Raman probe, and exciting light is guided to checking matter by described each Raman probe, and the Raman diffused light that checking matter produces is sent back inspection center.
Summary of the invention
Phasmon is the object of the present invention is to provide to strengthen Raman spectrum dynamic detection system.
The present invention is provided with support, spectrometer, light shield, guide rail, catoptron, catoptron lens barrel, upper motor, condenser, condenser lens barrel, CD shape sample cell, lower motor and control circuit;
Described spectrometer is fixed on rack platform, and catoptron lens barrel is arranged on guide rail, and catoptron lens barrel and condenser lens barrel utilize screw thread to match, and rotary condenser lens barrel regulates condenser from the distance between CD shape sample cell, reaches the object of focusing; Be connected by scalable light shield between spectrometer with catoptron lens barrel;
After the laser that spectrometer sends is reflected by catoptron, through converging on CD shape sample cell after condenser, catoptron lens barrel can along guide rail tangential movement under the control of upper motor, can carry out dynamic acquisition to the Raman signal that testing sample in the middle of microchannel on CD shape sample cell and Raman strengthen sample in mix particles, detachment process, control circuit is electrically connected with upper motor and lower motor.
The present invention is applied to Surface enhanced raman spectroscopy detection system micro-fluidic CD shape sample stage, by automatic control realization inspection correlated samples system quickly and accurately.The present invention has that required sample size is little, structure is simple, easy to detect, accuracy high.
Accompanying drawing explanation
Fig. 1 is the structure composition schematic diagram of the embodiment of the present invention.
Fig. 2 is the A-A cut-open view of Fig. 1.
Embodiment
See Fig. 1 and 2, the embodiment of the present invention is provided with support 1, spectrometer 2, light shield 3, guide rail 4, catoptron 5, catoptron lens barrel 6, upper motor 7, condenser 8, condenser lens barrel 9, CD shape sample cell 10, lower motor 11 and control circuit 12.
Spectrometer 2 is fixed on support 1, catoptron 5 is arranged in catoptron lens barrel 6, condenser 8 is arranged in condenser lens barrel 9, catoptron lens barrel 6 is fixed in guide rail 4, be connected with scalable light shield 3 between spectrometer 2 to catoptron lens barrel 6, catoptron lens barrel 6 and condenser lens barrel 9 utilize screw thread to match, rotary condenser lens barrel 9 can regulate condenser 8 from the distance between CD shape sample cell 10, upper motor 7 is fixed on support 1, be positioned at the dead astern of guide rail 4, catoptron lens barrel 6 utilizes mechanical drive to be connected with upper motor 7, move along guide rail 4 in the horizontal direction to control whole lens barrel by controlling upper motor 7, lower motor 11 is fixed on immediately below guide rail 4, CD shape sample cell 10 is fixed on lower motor 11, control circuit 12 is fixed on support 1, be positioned at below spectrometer 2, control circuit 12 is electrically connected with upper motor 7 and lower motor 11.
The present invention can consider efficiency and the portability of detection, is combined with using the CD shape sample cell of microflow control technique, reaches quick, accurate, effective detection and strengthens Raman signal.
Claims (1)
1. phasmon strengthens Raman spectrum dynamic detection system, it is characterized in that being provided with support, spectrometer, scalable light shield, guide rail, catoptron, catoptron lens barrel, upper motor, condenser, condenser lens barrel, CD shape sample cell, lower motor and control circuit;
Described spectrometer is fixed on rack platform, and catoptron lens barrel is arranged on guide rail, and catoptron lens barrel and condenser lens barrel utilize screw thread to match, and rotary condenser lens barrel regulates condenser from the distance between CD shape sample cell, reaches the object of focusing; Be connected by scalable light shield between spectrometer with catoptron lens barrel;
After the laser that spectrometer sends is reflected by catoptron, through converging on CD shape sample cell after condenser, catoptron lens barrel can along guide rail tangential movement under the control of upper motor, can carry out dynamic acquisition to the Raman signal that testing sample in the middle of microchannel on CD shape sample cell and Raman strengthen sample in mix particles, detachment process, control circuit is electrically connected with upper motor and lower motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410023821.7A CN103743721B (en) | 2014-01-20 | 2014-01-20 | Phasmon strengthens Raman spectrum dynamic detection system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410023821.7A CN103743721B (en) | 2014-01-20 | 2014-01-20 | Phasmon strengthens Raman spectrum dynamic detection system |
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| Publication Number | Publication Date |
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| CN103743721A CN103743721A (en) | 2014-04-23 |
| CN103743721B true CN103743721B (en) | 2015-10-14 |
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| CN201410023821.7A Active CN103743721B (en) | 2014-01-20 | 2014-01-20 | Phasmon strengthens Raman spectrum dynamic detection system |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106226282A (en) * | 2016-06-24 | 2016-12-14 | 北京华泰诺安探测技术有限公司 | A kind of laser Raman spectrometer is used to carry out the device and method sampled |
| CN106769693A (en) * | 2016-11-14 | 2017-05-31 | 中国科学院重庆绿色智能技术研究院 | A kind of circulating tumor cell automatic checkout system based on Raman spectrum |
Citations (6)
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| CN1339708A (en) * | 2000-08-16 | 2002-03-13 | 索尼株式会社 | Connection device of optical parts and optical module using said device |
| CN101504371A (en) * | 2009-03-05 | 2009-08-12 | 中国检验检疫科学研究院 | Quantitative determination instrument for melamine content in liquid milk |
| CN101545742A (en) * | 2008-03-26 | 2009-09-30 | 深圳市金凯进光电仪器有限公司 | High grade sighting telescope with telescopic foldable eyepatch and telescopic lens hood |
| CN101587074A (en) * | 2009-06-23 | 2009-11-25 | 华中科技大学 | Component analyzer for laser probe micro-area |
| CN101919847A (en) * | 2003-06-06 | 2010-12-22 | 菲布罗根公司 | Strengthen the application of erythropoietic HIF alpha stabilizers |
| CN102928397A (en) * | 2012-11-07 | 2013-02-13 | 厦门大学 | Optical system of holographic needlepoint enhanced Raman spectrometer |
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2014
- 2014-01-20 CN CN201410023821.7A patent/CN103743721B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1339708A (en) * | 2000-08-16 | 2002-03-13 | 索尼株式会社 | Connection device of optical parts and optical module using said device |
| CN101919847A (en) * | 2003-06-06 | 2010-12-22 | 菲布罗根公司 | Strengthen the application of erythropoietic HIF alpha stabilizers |
| CN101545742A (en) * | 2008-03-26 | 2009-09-30 | 深圳市金凯进光电仪器有限公司 | High grade sighting telescope with telescopic foldable eyepatch and telescopic lens hood |
| CN101504371A (en) * | 2009-03-05 | 2009-08-12 | 中国检验检疫科学研究院 | Quantitative determination instrument for melamine content in liquid milk |
| CN101587074A (en) * | 2009-06-23 | 2009-11-25 | 华中科技大学 | Component analyzer for laser probe micro-area |
| CN102928397A (en) * | 2012-11-07 | 2013-02-13 | 厦门大学 | Optical system of holographic needlepoint enhanced Raman spectrometer |
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| CN103743721A (en) | 2014-04-23 |
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