CN103494737B - Cosmetic preparation using ginger flower as anti-ageing and skin-protecting factor and preparation method of cosmetic preparation - Google Patents
Cosmetic preparation using ginger flower as anti-ageing and skin-protecting factor and preparation method of cosmetic preparation Download PDFInfo
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Abstract
The invention discloses a cosmetic preparation using ginger flowers as an anti-ageing and skin-protecting factor and a preparation method of the cosmetic preparation. The cosmetic preparation comprises 6.01-30.5wt of a base material, 5-75wt of an oil-phase raw material and 15-85wt of a water-phase raw material, wherein the base material comprises 5-20 percent of ginger flower gel lyophilized powder, 1-10 percent of vitamin E and 0.01-0.5 percent of hyaluronic acid. The cosmetic preparation has the beautifying effects of resisting free radicals, resisting oxidization and radiation, resisting bacteria, promoting skin cell proliferation, preventing oxidative damages of the skin, reducing melanogenesis, delaying ageing of the skin, and the like, has no stimulation and anaphylactic reaction on the skin and mucosa, is capable of endowing a special faint scent of the ginger flower to products, and can be applied to multiple kinds of skin protection agents such as cream, emulsion, facial cleansing lotion, and facial mask.
Description
Technical field
The invention belongs to daily cosmetics field.The present invention relates to a kind of plant Hedychium coronarium Koenig (Hedychiumcoronarium) as the application of Anti-aging Factor For Skin Protection in skin protectant.
Background technology
Along with life and the raising of educational level, cosmetic product is more and more subject to people's attention.Because active components of plants has, effect is good, side effect is little, so the cosmetics based on active components of plants are more and more subject to the favor of consumer.At present, foreign applications about has 500 kinds in the plant of cosmetics, and their effects in cosmetics roughly can be divided into anti-inflammatory anti-itch, softening moisturizing, convergence conditioning, anti-pigmented spots, sun-proof anticracking, antiperspirant deodorant and anticorrosion, antioxidation etc.China starts from the eighties in 20th century research and development being just engaged in natural household chemicals field, use modern means of science and technology, natural active matter is extracted from resourceful plant, be applied to functional type cosmetics, successively successfully develop the serial daily chemical products such as Herba Taraxaci, the Pseudobulbus Bletillae (Rhizoma Bletillae), Aloe, Radix Glycyrrhizae, Flos Rosae Rugosae.
Skin is the outermost organ of human body; it covers whole body, and in protective, each tissue exempts from external mechanical, physical property, chemical or physiological invasion and attack, and participates in many physiological activities of collective; the important component part of body, the appearance of people and the mark of aging especially.Skin aging main manifestations is two aspects: 1. skin follows the string formation wrinkle gradually; 2. skin appearance produces the various mottle such as chloasma, senile plaque gradually.According to the free-radical theory of aging, the most the underlying cause causing human skin aging is thought in many scientist's research both at home and abroad, the side-product in cellular physiological events process---reactive oxygen free radical effect, the reactive oxygen free radical of organism is the product of cellular oxidation thing metabolism, it constantly produces, constantly be eliminated again, dysequilibrium is under normal condition, free radical scavenging activity reduces, body tissue cell biological macromole generation breaking reaction will be formed, collagenic protein in connective tissue is caused to be cross-linked, form insoluble molecule, destroy connective tissue, shorten its length, skin is made to occur wrinkle, free radical is degradable hyaluronic acid also, skin is followed the string and is subject to bacteriological infection, causes membrane lipid peroxidation chromogenesis.Composition as contained in fruit cosmetic can reduce the generation of skin free radical; improve the activity of SOD; to Skin Cell, there is certain proliferation function again, skin histology just can be made to upgrade accelerate, collagen fiber generate and increase, protect moisture of skin, thus slowing down skin aging effectively.This is also the target that skin-care cosmetics exploitation is endeavoured always.To sum up, the characteristics of the times of aged tendency of population and the special industry background residing for cosmetics are that the application of the plant extract with physiologically actives such as free radical resisting, antioxidation, radioprotective, antibacterial and antiinflammatories provides wide space.
Hedychium coronarium Koenig (Hedychium coronarium), is subordinate to Zingiberaceae (Zingiberaceae) Hedychium Koenig, another name Herba Iridis japonicae, sulphur butterfly.According to " Chinese medicine voluminous dictionary " record, its root stock (having another name called Rhizoma Hedychii Coronarii) and fruit, can warming middle-JIAO stomach invigorating, expelling wind, dissipating cold, relieving the exterior syndrome by diaphoresis, control headache, general pain, rheumatism etc.In addition, the quintessence oil extracted from Hedychium coronarium Koenig has the effect regulating emotion, pressure release, increase confidence, even also has certain therapeutical effect to various gynecological diseases, is often added pastil by as food and cosmetics of everyday use.Although the exploitation of Hedychium coronarium Koenig has larger economic worth, all the time, its bioactive research still rests on monomer with on theoretical activity research: foreign scholar is separated and obtains 8 diterpene from Hedychium coronarium Koenig, wherein 4 tool cytotoxicities; Shrotriya etc. find that the chloroform extract of Hedychium coronarium Koenig rhizome has good antiinflammatory, analgesic activity; Joy etc. are studied the volatile oil component of Hedychium coronarium Koenig rhizome and bacteriostatic activity again.At home, the research of Hedychium coronarium Koenig is then only only limitted to the separation of volatile oil and ter penoids.Except essence and flavoring agent, domestic very few to the exploitation of Hedychium coronarium Koenig in daily chemical products.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of cosmetic formulations using Hedychium coronarium Koenig as Anti-aging Factor For Skin Protection and preparation method are provided, the present invention provides a kind of Anti-aging Factor For Skin Protection of natural botanical source for cosmetic industry, and to have free radical resisting, antioxidation, radioprotective, antibacterial, whitening, Hedychium coronarium Koenig that is crease-resistant, spot-removal function prepare natural activity skin care formulation as Anti-aging Factor For Skin Protection.
The object of the invention is to be achieved through the following technical solutions: a kind of cosmetic formulations using Hedychium coronarium Koenig as Anti-aging Factor For Skin Protection, described cosmetic formulations by mass content be the base material of 6.01-30.5%, the oil phase raw material of 5 ~ 75% and 15 ~ 85% Aqueous Phase Raw Material form, wherein, described base material is 5 ~ 20% by mass content Hedychium coronarium Koenig gel lyophilized powder, the vitamin E of 1 ~ 10% and the hyaluronic acid of 0.01 ~ 0.5% form; Described oil phase raw material is oil-soluble emollient, and described Aqueous Phase Raw Material is polar solvent.
Further, described oil-soluble emollient comprises steroid, wax fat, fatty alcohol, phospholipid, triglyceride, polyol resin, fatty alcohol ether, alkyl fatty esters, hydrocarbon-type oil and wax, hydrophilicity lanolin derivant, silicone oil, hydrophilic beeswax derivatives.
Further, described polar solvent by water, glycerol, ethanol, Polyethylene Glycol one or more form by any proportioning.Be preferably water.
The preparation method of the above-mentioned cosmetic formulations using Hedychium coronarium Koenig as Anti-aging Factor For Skin Protection is specially: draw materials according to the weight proportion of oil phase raw material 5 ~ 75%, Aqueous Phase Raw Material 15 ~ 85%, Hedychium coronarium Koenig gel lyophilized powder 5 ~ 20%, vitamin e1 ~ 10% and hyaluronic acid 0.01 ~ 0.5%, respectively by oil phase heating raw materials to 70 ~ 90 DEG C of sterilizings about 15 ~ 25 minutes, Aqueous Phase Raw Material is heated to 80 ~ 90 DEG C of sterilizings about 15 ~ 25 minutes, is all cooled to 60 ~ 70 DEG C.Then oil phase raw material is joined in Aqueous Phase Raw Material slowly, make it fully emulsified, continue slowly to stir, be cooled to 35 ~ 45 DEG C, add Hedychium coronarium Koenig gel lyophilized powder, vitamin E and hyaluronic acid, stir.
Further, when adding Hedychium coronarium Koenig gel lyophilized powder, vitamin E and hyaluronic acid, essence and 0.1 ~ 1% pigment that percentage by weight is 0.1 ~ 1% can also be added simultaneously.
Further, described Hedychium coronarium Koenig gel lyophilized powder prepares by the following method: by smash through the Hedychium coronarium Koenig petal of clean starch into Hedychium coronarium Koenig juice after filter, centrifugal, concentrated after Hedychium coronarium Koenig gel concentrated juice, add the ethanol of 5 times of volumes to Hedychium coronarium Koenig gel concentrated juice, fully stir under room temperature, leave standstill 1 ~ 3 hour, filter, reclaim ethanol, collect Hedychium coronarium Koenig juice, then row filters, collect filtrate, after filtrate being filtered, collect concentrated solution, further lyophilization, freeze-dried powder crosses 120 mesh sieves, to obtain final product.
The invention has the beneficial effects as follows, the present invention compared to the prior art, there is following technique effect: the Anti-aging Factor For Skin Protection 1. providing a kind of natural green---Hedychium coronarium Koenig, systematic study has been carried out to its feature relevant to skin physiology function, show its have free radical resisting, antioxidation, radioprotective, antibacterial, promote skin cell proliferation, prevent the oxidative damage of skin, reduce the beauty functions such as B16 cell, delay skin aging, and product can be given with the distinctive delicate fragrance of Hedychium coronarium Koenig.2. the raw material sources that the present invention relates to are wide, cost is low, safe and reliable, and manufacturing process is simple, are applicable to suitability for industrialized production, have broad application prospects in daily skin protection cosmetics field.
Accompanying drawing explanation
Fig. 1 is for using front skin table condition figure;
Fig. 2 is skin table condition figure after use the present invention in 4 weeks continuously;
Fig. 3 is for using front skin table condition figure;
Fig. 4 is skin table condition figure after use the present invention in 4 weeks continuously.
Detailed description of the invention
The invention provides a kind of cosmetic formulations using Hedychium coronarium Koenig as Anti-aging Factor For Skin Protection, described cosmetic formulations by mass content be the base material of 6.01-30.5%, the oil phase raw material of 5 ~ 75% and 15 ~ 85% Aqueous Phase Raw Material form, wherein, base material is 5 ~ 20% by mass content Hedychium coronarium Koenig gel lyophilized powder, the vitamin E of 1 ~ 10% and the hyaluronic acid of 0.01 ~ 0.5% form.Described oil phase raw material is oil-soluble emollient, and described Aqueous Phase Raw Material is polar solvent.
Skin care formulation using Hedychium coronarium Koenig as important component provided by the invention, each material composition respectively has special effect, works in coordination with as use, and effect doubles.Hedychium coronarium Koenig gel lyophilized powder in raw material is a kind of antioxidant, can effective scavenging activated oxygen, anti-lipid peroxidation, and protection skin is from infringement, thus the generation of check melanin effectively, can skin splash be desalinated to a certain extent; Can give the epithelial cells in keratodermatitis hydrophilic power, collection is wet increases profit, allows skin be in moistening, soft condition simultaneously; There are convergence and opsonic action to dermatitis and local histone, can skin mucosa be protected.Vitamin E in raw material effectively scavenging activated oxygen, anti-lipid peroxidation can prevent the generation of lipofuscin and various mottle; On the other hand again by blood circulation promoting regulates qi, prevent that endodermis moisture content scatters and disappears, anti-inflammation protects skin and ensure the nutrition of skin.Hyaluronic acid in raw material has hygroscopicity, in conjunction with a large amount of moisture content, can have effect of moisturizing, thus strengthen the barrier of skin, can prevent scattering and disappearing of skin moisture, effectively protects that regenerative cell's is aging.
Oil-soluble emollient comprises: 1. steroid, as: cholesterol and other lanolin alcohols; 2. wax fat, as: lanoline, Cera Flava, spermaceti; 3. fatty alcohol, as: lauryl alcohol, oleyl alcohol, spermol and ester cerotin; 4. phospholipid: lecithin and cephalin; 5. triglyceride: various animal and plant fat; 6. polyol resin, as: the mono fatty acid of ethylene glycol, propylene glycol, glycerol, diethylene glycol, sorbitol, mannitol, Polyethylene Glycol, sorbitol anhydride, tetramethylolmethane, polyoxyethylene sorbitol, polyoxyethylene sorbitol acid anhydride, polyoxyethylene sorbitol acid anhydride and double acid ester; 7. fatty alcohol ether, as: the ethylene oxide adduct of spermol, ester cerotin or oleyl alcohol etc.; 8. alkyl fatty esters, as the methyl ester of: fatty acid, second third fat and fourth fat; 9. alkanes oil and wax, as: Dormant oils, vaseline and paraffin; 10. hydrophilicity lanolin derivant, as: polyoxyethylene sorbitol lanoline and Wool wax alcohols,ethoxylated derivant;
silicone oil, as: polysiloxanes and methyl polysiloxane;
hydrophilic beeswax derivatives, as: polyoxyethylene sorbitol Cera Flava.
Polar solvent by water, glycerol, ethanol, Polyethylene Glycol one or more form by any proportioning, should guarantee that there is enough polarity.The preferred polar solvent of the present invention is water.
The present invention is using Hedychium coronarium Koenig as the cosmetic formulations of Anti-aging Factor For Skin Protection, prepare by the following method: draw materials according to the weight proportion of oil phase raw material 5 ~ 75%, Aqueous Phase Raw Material 15 ~ 85%, Hedychium coronarium Koenig gel lyophilized powder 5 ~ 20%, vitamin e1 ~ 10% and hyaluronic acid 0.01 ~ 0.5%, respectively by oil phase heating raw materials to 70 ~ 90 DEG C of sterilizings 15 ~ 25 minutes, Aqueous Phase Raw Material is heated to 80 ~ 90 DEG C of sterilizings 15 ~ 25 minutes, is all cooled to 60 ~ 70 DEG C.Then oil phase raw material is joined in Aqueous Phase Raw Material slowly, make it fully emulsified, continue slowly to stir, be cooled to 35 ~ 45 DEG C, add Hedychium coronarium Koenig gel lyophilized powder, vitamin E and hyaluronic acid, stir.
When adding Hedychium coronarium Koenig gel lyophilized powder, vitamin E and hyaluronic acid, can also add percentage by weight is the essence of 0.1 ~ 1% and the pigment of 0.1 ~ 1% simultaneously.
The preparation method of Hedychium coronarium Koenig gel lyophilized powder is as follows: by smash through the Hedychium coronarium Koenig petal of clean starch into Hedychium coronarium Koenig juice after filter, centrifugal, concentrated after Hedychium coronarium Koenig gel concentrated juice, add the ethanol of 5 times of volumes to Hedychium coronarium Koenig gel concentrated juice, fully stir under room temperature, leave standstill 1 ~ 3 hour, filter, reclaim ethanol, collect Hedychium coronarium Koenig juice, row filters again, collects filtrate, after filtrate being filtered, collect concentrated solution, further lyophilization, freeze-dried powder crosses 120 mesh sieves, to obtain final product.
Described Hedychium coronarium Koenig gel lyophilized powder is 1/20 times (by weight) of original Hedychium coronarium Koenig juice.
The present invention can also comprise other optional members, that is: pH adjusting agent, antioxidant, chelating agen, wetting agent, increasing rare dose, and thickening agent, surfactant, antiseptic, pigment and spice suitably add as required; In addition, also can with other active component, as blood circulation accelerant, disinfectant, cell activator, amino acids, vitamins, wetting agent and keratolytic agent etc. are combined.
The present invention can select different skin protection base materials according to different product forms and different applications using Hedychium coronarium Koenig as the skin care formulation of important component, makes the various skin protection dosage forms such as cream, Emulsion, cleanser liquid, facial film.
In order to understand essence of the present invention better, the skin physiology correlational study below by Hedychium coronarium Koenig gel lyophilized powder illustrates effect of its skin protection.
1. antioxidation, the anti-aging effects of Hedychium coronarium Koenig gel lyophilized powder
By measuring the change of strong proline content in mouse skin and tail tendon; show that Hedychium coronarium Koenig gel lyophilized powder just demonstrates the positive-effect to collagen protein when low dosage, show the activity having antioxidation, anti-lipid peroxidation product, remove lipofuscin and protection collagen protein.
2. free radical resisting, the radiation resistance of Hedychium coronarium Koenig gel lyophilized powder
By research techniques such as faint chemiluminescence analysis and fluorophotometric analysiss, comparative study Hedychium coronarium Koenig gel lyophilized powder, Aloe extract and tea polyphenols remove O
. 2with
.the activity of OH and right
60co-γ irradiation and CuSO
4-Phen-Vc-H
2o
2in-DNA system
.the protective effect of DNA damage caused by OH.
(1) O is removed
. 2 -with
.the comparison of OH ability
Table 1: the Performance comparision of three class plant extract scavenging capacity oxygen-derived free radicals
| Extract kind | Remove O · 2IC 50（μg/mL) | Remove ·The IC of OH 50（mg/mL) |
| Hedychium coronarium Koenig gel lyophilized powder | 3.29 | 1.65 |
| Aloe extract | 3.23 | 1.53 |
| Tea polyphenols | 3.08 | 1.04 |
Relatively O removed by three kinds of samples
. 2 -with
.the ability (table 1) of OH, closely, tea polyphenols is slightly better than them for Hedychium coronarium Koenig gel lyophilized powder and Aloe extract, infers relevant with the high-purity of tea polyphenols.
(2) on the impact of EB-DNA system fluorescent characteristic
Table 2: three Plant Extracts are to the suppression ratio of EB-DNA system fluorescence intensity
Three kinds of extract suppression to EB-DNA system fluorescence intensity are significant concentration-dependent relation (table 2), from IC
50value compares, and Hedychium coronarium Koenig gel lyophilized powder and Aloe extract are very close, are all better than tea polyphenols.
(3) to the protective effect of DNA radiation damage
Irradiation can produce direct effect and indirect effect to DNA solution.Direct effect can cause that DNA molecular hydrogen bond destroys, Double helix is untied, base comes off, Single and double strand breakage etc.; Indirect effect mainly due to the evil free radical that produces during irradiation, especially
.oH, attacks DNA chain, causes the damage of DNA molecular.Result causes EB and DNA binding site to reduce, and fluorescence intensity level also just reduces.
Table 3: three Plant Extracts are on the impact of EB-DNA fluorescence intensity during various dose irradiation
Table 3 respectively illustrates variety classes, variable concentrations sample at different dosages on the impact of EB-DNA fluorescence intensity.Hedychium coronarium Koenig gel lyophilized powder, Aloe extract and tea polyphenols, in the concentration range of 50 ~ 100 μ g/mL, all can make the fluorescence intensity of EB-DNA remain on higher level, illustrate that three kinds of materials have the effect of protection DNA irradiation damage, and display density dependence.Look down upon greatly from the protective effect of three kinds of extracts, tea polyphenols is slightly better than Hedychium coronarium Koenig gel lyophilized powder and Aloe extract, and rear both are close.
(4) to CuSO
4-Phen-Vc-H
2o
2the dynamic (dynamical) impact of-DNA chemiluminescence
CuSO
4-Phen-Vc-H
2o
2-DNA chemical luminophor ties up to Hedychium coronarium Koenig gel lyophilized powder, Aloe extract and tea polyphenols three kinds of samples and deposits in case, and leading peak, rear peak-to-peak value decline quite obvious, and its 503nhibiting concentration is about 0.2 μ g/mL.Cause the decline of luminescence peak due to antioxidant for clearing and start chain reaction
.oH etc., decrease
.the DNA damage that OH etc. cause, thinks that the extracts such as Hedychium coronarium Koenig gel lyophilized powder serve the effect of prevention type antioxidant.Also find out, the time of occurrence of front peak-to-peak value has almost no change, and then peak-to-peak value is delayed simultaneously, and with the increase of antioxidant concentration, after peak value, shift time extends.Think and cause the time delay of postpeak luminescence peak to be because sample removes the Intermediate radical of free chain reaction, chain reaction is interrupted, serve the effect of protection DNA radical damage, illustrate that the extracts such as Hedychium coronarium Koenig gel lyophilized powder have been the antioxidants of chain scission.
3. antibacterial, the antiinflammatory action of Hedychium coronarium Koenig gel lyophilized powder
(1) bacteriostasis
Select micrococcus scarlatinae (Streptococcus pyogenes ATCC12344), staphylococcus epidermidis (Staphylococcus epidermidis ATCC12228), staphylococcus aureus (Staphylococcusaureus ATCC25923), escherichia coli (Escherichia coli ATCC25922), carry out extracorporeal bacteria inhibitor test with reference to " Department of Medical Administration of Ministry of Health of the People's Republic of China whole nation Clinical Laboratory rule of operation " second edition.
Table 4: the bacteriostasis of Hedychium coronarium Koenig gel lyophilized powder
The above results (table 4) shows that Hedychium coronarium Koenig gel lyophilized powder all has inhibitory action in various degree to above-mentioned 4 kinds of antibacterials.
(2) antiinflammatory action
Oleum Tiglii is adopted to cause the antiinflammatory action of mice auricle swelling method inspection Hedychium coronarium Koenig gel lyophilized powder.Experimental result (table 5) shows, mouse stomach gives the Hedychium coronarium Koenig gel lyophilized powder of 200 mg/kg and 400 mg/kg dosage after continuous 7 days, to auricle edema caused by Oleum Tiglii have significantly (
*p ﹤ 0.05) and extremely significantly (
*p ﹤ 0.01) inhibitory action, and in dose-dependence significantly.
Table 5: Hedychium coronarium Koenig gel lyophilized powder is on the impact of auricle edema caused by mouse knoting oil
| Group | Dosage (mg/kg body weight) | Number of animals (only) | Auricle edema rate (mg) |
| Blank group | Normal saline | 10 | 19.7±3.0 |
| Positive drug control group | 10(indometacin) | 10 | 14.2±5.6 ** |
| Low dose group | 100 | 10 | 18.4±3.3 |
| Middle dosage group | 200 | 10 | 16.8±2.2 * |
| High dose group | 400 | 10 | 15.5±1.7 ** |
Note: compared with matched group,
*p ﹤ 0.05;
*p ﹤ 0.01.
The skin physiological activities of Hedychium coronarium Koenig gel lyophilized powder
(1) to the proliferation function of Skin Cell
Table 6: Hedychium coronarium Koenig gel lyophilized powder is on the impact of two kinds of skin ability of cell proliferation
| Sample solution concentration (%) | Keratinocyte | Fibroblast |
| Blank | 0.290±0.063 | 0.328±0.068 |
| 0.5×10 -3 | 0.447±0.123 | 0.430±0.079 |
| 0.5×10 -2 | 0.537±0.133* | 0.509±0.033 * |
| 0.5×10 -1 | 0.615±0.088 ** | 0.399±0.052 |
Note: compared with matched group,
*p ﹤ 0.05;
*p ﹤ 0.01.
The above results (table 6) display Hedychium coronarium Koenig gel lyophilized powder is 0.5 × 10
-2~ 0.5 × 10
-1there is in % dosage range the effect promoting skin cell proliferation, wherein the proliferation function of cell is formed 0.5 × 10 to skin keratin
-2remarkable during % concentration (
*p ﹤ 0.05), 0.5 × 10
-1extremely remarkable during % concentration (
*p ﹤ 0.01); Also significant difference is had compared with matched group to the multiplication capacity of skin flbroblast.
(2) on the impact of Skin Cell MDA growing amount and SOD activity
From table 7 result, Hedychium coronarium Koenig gel lyophilized powder is 0.5 × 10
-3~ 0.5 × 10
-2there is the effect of lowering lipid peroxide MDA and generating, improving antioxidase SOD activity, wherein 0.5 × 10 in % dosage range
-2% dosage group have compared with matched group significance (
*p ﹤ 0.05).
Table 7: Hedychium coronarium Koenig gel lyophilized powder forms the impact of cell MDA generation and SOD activity to skin keratin
| Sample solution concentration (%) | MDA（nmol/mL） | SOD（U/mL） |
| Blank | 1.67±0.25 | 2.95±0.08 |
| 0.5×10 -3 | 1.41±0.48 | 3.00±0.15 |
| 0.5×10 -2 | 1.12±0.17 * | 3.26±0.22 * |
| 0.5×10 -1 | 2.24±0.80 | 2.50±0.11 |
Note: compared with matched group,
*p ﹤ 0.05.
(3) skin whitening efficacy
Table 8: Hedychium coronarium Koenig gel lyophilized powder is on the impact of B16 melanocyte tumor cell tyrosinase activity and melanin genesis
Note: compared with matched group,
*p ﹤ 0.05;
*p ﹤ 0.01.
By experiment known (table 8), B16 melanocyte tumor cell Tyrosinase inhibition assays result shows, Hedychium coronarium Koenig gel lyophilized powder has no significant effect this enzymatic activity; And learnt by melanin genesis result of the test, Hedychium coronarium Koenig gel lyophilized powder is 0.5 × 10
-2~ 0.5 × 10
-1to melanin genesis, there is significant inhibitory action during % concentration.
(4) cutaneous safety evaluation test
Skin Irritation Test and eye irritant test understand exotic when with skin or mucosal contact, and whether skin generation is stimulated to detrimental effect or causes mucosa generation inflammatory lesion, be the essential items for inspection of cosmetics and raw materials for production safety evaluatio thereof.Test result shows, and Skin Irritation Test and the eye irritant test result of Hedychium coronarium Koenig gel lyophilized powder are feminine gender, show under external preparation for skin condition, and it can not produce stimulation to human body skin and mucosa.
(5) human skin patch
Select qualified speckle examination device, with closed patch test method, tested material Hedychium coronarium Koenig gel lyophilized powder being about 0.1g, to be dissolved in distilled water appropriate, and drip in speckle examination device, external special adhesive tape is applied to experimenter back, remove tested material after 24 hours, within 0.5,24,48 hour, observe dermoreaction after removal respectively, by its result of dermoreaction grade scale record in " cosmetics health specification " (version in 2007).Result of the test is as table 9.
Table 9: human skin patch result
Human skin patch result shows: in 50 people, skin adverse reaction appears in 0 example; The use safety of Hedychium coronarium Koenig gel lyophilized powder is described.
(6) whitening, freckle effect test
Experimenter is at left and right cheek successively cycle labeling: using the area of 4 × 4cm size as tested region and blank region.Experimenter uses the aqueous solution twice of Hedychium coronarium Koenig gel lyophilized powder every day sooner or later in Experimental Area, experimental session, experimenter no longer smears any other cosmetics at Test sites.Experimenter is after using tested material one week, two weeks, three weeks and surrounding continuously, same time experimenter will smear position and clean weekly, use Mexameter MX18 tester and MicroSkin II Multi-functional skin mirror image analysis system to measure the content smearing position by tester.After data measured is added up, analyzing skin color Changing Pattern.Result shows, after Hedychium coronarium Koenig gel lyophilized powder uses 1 week compared with blank group, melanin content obviously reduces (p ﹤ 0.05); Check melanin successful after using 4 weeks, and there is persistence.
To sum up, Hedychium coronarium Koenig gel lyophilized powder has good biological action to Skin Cell, can promote that skin keratin forms cell and fibroblastic multiplication capacity, improve SOD active simultaneously, reduce oxidative damage, the active substance that prompting Hedychium coronarium Koenig gel lyophilized powder can be used as delay skin aging is applied in cosmetics.The test of skin-whitening, spot-removing function finds, Hedychium coronarium Koenig gel lyophilized powder effectively can reduce the content of melanocyte synthesis melanocyte, to a certain extent skin whitening, mottle is disappeared take off.
Following example, can be for reference in order to further illustrate the present invention, but do not limit the scope of the invention thus.
Embodiment 1 ~ 3:
Take each raw material (table 10) by weight ratio.By oil phase heating raw materials to 70 DEG C, Aqueous Phase Raw Material is heated to 90 DEG C, maintains sterilizing in 25 minutes, is cooled to 70 DEG C.Then oil phase raw material is joined in Aqueous Phase Raw Material solution slowly, make it fully emulsified, continue slowly to stir, be cooled to 45 DEG C, add Hedychium coronarium Koenig gel lyophilized powder, vitamin E and hyaluronic acid by proportioning, and add appropriate amount of essence, pigment, stir.
Table 10: Hedychium coronarium Koenig is as the application example of Anti-aging Factor For Skin Protection in skin protection cosmetics preparation
Note: owing to containing appropriate water in active component, add the water gross weight to 100 in active component.
As Fig. 1 and Fig. 2 contrasts visible, through on probation, embodiment 1-3 all has certain beauty functions to skin: promote skin metabolism, moistening epidermis, suppress different shape sebum secretion, and activating cell, desalination melanin.
Embodiment 4 ~ 6:
Take each raw material (table 11) by weight ratio.By oil phase heating raw materials to 90 DEG C, Aqueous Phase Raw Material is heated to 80 DEG C, maintains sterilizing in 15 minutes, is cooled to 60 DEG C.Then oil phase raw material is joined in Aqueous Phase Raw Material solution slowly, make it fully emulsified, continue slowly to stir, be cooled to 35 DEG C, add Hedychium coronarium Koenig gel lyophilized powder, vitamin E and hyaluronic acid by proportioning, and add appropriate amount of essence, pigment, stir.
Table 11: Hedychium coronarium Koenig is as the application example (Continued) of Anti-aging Factor For Skin Protection in skin protection cosmetics preparation
As Fig. 3 and Fig. 4 contrasts visible, experiment proves, skin protection cosmetics preparation prepared by the present embodiment 4-6 all has harmful bacteria, activating skin cells, conditioning skin and desalination melanin effect of suppressing skin surface.
Above-described embodiment is used for explaining and the present invention is described, instead of limits the invention, and in the protection domain of spirit of the present invention and claim, any amendment make the present invention and change, all fall into protection scope of the present invention.
Claims (5)
1. one kind using Hedychium coronarium Koenig as the cosmetic formulations of Anti-aging Factor For Skin Protection, it is characterized in that, described cosmetic formulations by mass content be 5 ~ 20% Hedychium coronarium Koenig gel lyophilized powder, 1 ~ 10% vitamin E, the hyaluronic acid of 0.01 ~ 0.5%, the oil phase raw material of 5 ~ 75% and 15 ~ 85% Aqueous Phase Raw Material form, described oil phase raw material is oil-soluble emollient, and described Aqueous Phase Raw Material is polar solvent; Described Hedychium coronarium Koenig gel lyophilized powder prepares by the following method: by smash through the Hedychium coronarium Koenig petal of clean starch into Hedychium coronarium Koenig juice after filter, centrifugal, concentrated after Hedychium coronarium Koenig gel concentrated juice, add the ethanol of 5 times of volumes to Hedychium coronarium Koenig gel concentrated juice, fully stir under room temperature, leave standstill 1 ~ 3 hour, filter, reclaim ethanol, collect Hedychium coronarium Koenig juice, row filters again, collects filtrate, after filtrate being filtered, collect concentrated solution, further lyophilization, freeze-dried powder crosses 120 mesh sieves, to obtain final product.
2. according to claim 1 using Hedychium coronarium Koenig as the cosmetic formulations of Anti-aging Factor For Skin Protection, it is characterized in that, described oil-soluble emollient is selected from steroid, wax fat, fatty alcohol, phospholipid, polyol resin, fatty alcohol ether, alkyl fatty esters, hydrocarbon-type oil, silicone oil.
3., according to claim 1 using Hedychium coronarium Koenig as the cosmetic formulations of Anti-aging Factor For Skin Protection, it is characterized in that, described polar solvent by water, glycerol, ethanol, Polyethylene Glycol one or more form by any proportioning.
4., according to claim 3 using Hedychium coronarium Koenig as the cosmetic formulations of Anti-aging Factor For Skin Protection, it is characterized in that, described polar solvent is water.
5. described in a claim 1 using Hedychium coronarium Koenig as the preparation method of the cosmetic formulations of Anti-aging Factor For Skin Protection, it is characterized in that, the method is specially: according to oil phase raw material 5 ~ 75%, Aqueous Phase Raw Material 15 ~ 85%, Hedychium coronarium Koenig gel lyophilized powder 5 ~ 20%, the weight proportion of vitamin e1 ~ 10% and hyaluronic acid 0.01 ~ 0.5% is drawn materials, respectively by oil phase heating raw materials to 70 ~ 90 DEG C of sterilizings 15 ~ 25 minutes, Aqueous Phase Raw Material is heated to 80 ~ 90 DEG C of sterilizings 15 ~ 25 minutes, all be cooled to 60 ~ 70 DEG C, then oil phase raw material is joined in Aqueous Phase Raw Material slowly, make it fully emulsified, continue slowly to stir, be cooled to 35 ~ 45 DEG C, add Hedychium coronarium Koenig gel lyophilized powder, vitamin E and hyaluronic acid, stir.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR3074684A1 (en) * | 2017-12-08 | 2019-06-14 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | NEW ANTI-STRESS SKIN PROCESS INDUCED BY BLUE LIGHT EXPOSURE |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3342465A1 (en) * | 2016-12-30 | 2018-07-04 | Bayer Consumer Care AG | Hedychium extract and compositions thereof and their use in the treatment of skin affected by harmful environmental influences |
| US20200188291A1 (en) * | 2017-05-17 | 2020-06-18 | Natura Cosméticos S.A. | Liposoluble anti-pollution cosmetic composition, cosmetic product, use and method for preventing and/or treating signs of extrinsic aging |
| CN111514054A (en) * | 2020-06-08 | 2020-08-11 | 云南菊开生物科技有限公司 | Composition for inhibiting tyrosinase activity, preparation method thereof and cosmetic |
| CN113101255A (en) * | 2021-04-19 | 2021-07-13 | 广东梵蜜琳生物科技有限公司 | Anti-premature composition and preparation method and application thereof |
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| CN102488638A (en) * | 2011-12-16 | 2012-06-13 | 江南大学 | Cosmetic with no or less emulsifier and preservative |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FR3074684A1 (en) * | 2017-12-08 | 2019-06-14 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | NEW ANTI-STRESS SKIN PROCESS INDUCED BY BLUE LIGHT EXPOSURE |
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