CN103405591A - Nourishing type water-soluble personal lubricant and preparation method thereof, and condom - Google Patents
Nourishing type water-soluble personal lubricant and preparation method thereof, and condom Download PDFInfo
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Abstract
The invention discloses a type water-soluble personal lubricant and a preparation method thereof, and a condom adopting the lubricant. A compact type water-soluble personal lubricant contains the following components in percentage by weight of 30-45 percent of glycerol, 2-4 percent of tween-20, 0.05-0.15 percent of sodium hyaluronate, 0.5-1.2 percent of aloes essential oil, 0.08-0.2 percent of flores aurantii essential oil, 0.1-0.3 percent of rose essential oil and 50-61.15 percent of water. The compact type water-soluble personal lubricant is good in compatibility with a personal natural secretion body fluid without greasiness, is consistent in pH value of a normal physiological environment of the vagina of a woman, and has the advantages of nourishing the vagina tissue, promoting the cell growth, and increasing the muscle elasticity.
Description
Technical field
The present invention relates to a kind of human body lubricants, a kind of water solublity nourishing type human body lubricants particularly, be applicable to especially in condom, sexual life increase that vagina is moistening or apparatus gynecological and surgery is lubricated (as the colon clinical thermometer etc.).
Background technology
Human body lubricants is mainly used in vaginal lubrication, namely can when sexual life, directly be applied to genital area, or for condom, be applicable to the vaginal dryness due to endocrine alteration, climacteric, gynecilogical operation or Nervous and Mental Factors etc., can certainly when gynecologial examination, smear in medical apparatus surface.
Vagina is lubricated is the important physiological performance of sexual life incipient stage, and normal vagina can keep certain wettability, and in the orgasm process, due to the accumulation of sexual excitation, vagina can produce secretions from less to more to lubricate vagina at sexual arousal.These lubricating fluids are mainly from the juice in uterus, the congested formed transudate of vaginal wall, and the greater vestibular gland juice that is positioned at vaginal orifice.If the lubricating fluid of secretion is not even secreted and will be caused vaginal dryness less, and vaginal dryness not only affects life quality, reduce women's happiness and self-confidence, also can weaken the natural defence capability of vagina.It is reported, the incidence rate of vagina lack of lubrication is higher than 70%, and major part is non-pathologic, and reason comprises that stress is excessive, uses condom, fertility, suckling, operation, oral contraceptive, climacteric, diabetes etc.The physiological vaginal dryness is common in postclimacteric women, surpasses 1/3 people and there will be this symptom but also have in the women in 18-29 year.For non-pathologic vaginal dryness, using safety, comfortable human body lubricants is optimum selection.In addition, along with improving constantly of people's living standard and know-how, and various contraceptive device and contraceptives knowledge is universal, the quick increase of non-marriage sexual behaviour in addition, and the use amount of condom is just increased sharply with annual 15% speed.Condom has just like become the first-selected instrument of people's contraception and prevention of STD propagation.
The condom surface scribbles human body lubricants, and the one, play the sexual life lubrication, the 2nd, avoid the latex adhesion.Yet the widely used lubricant of condom is the methyl-silicone oil lubricant at present.And methyl-silicone oil is to take dimethyldichlorosilane to be primary raw material, through hydrolysis, the siliconoxygen bond (Si-O) of take be main chain, the direct organic and inorganic compound of connection organic group on silicon atom.Methyl-silicone oil is colourless, tasteless, not volatile, water insoluble.Due to the character of methyl-silicone oil, determined the defect that it is intrinsic.Methyl-silicone oil is mainly reflected in following several aspect as the problem that the condom lubricant brings:
At first, the pH of methyl-silicone oil, between 8-9, is alkalescence.And vagina is faintly acid, life-time service be take methyl-silicone oil and can be destroyed the vagina acid-base value as the condom of lubricant, and then breaks the normal microecosystem of vagina, causes the vagina dysbacteriosis, thereby cause that vagina infects, the symptoms such as dry and astringent, pain, pruritus occur.
Secondly, methyl-silicone oil is water insoluble, cause take methyl-silicone oil as the condom of lubricant in use not strong with the human body affinity, make the people produce strong greasy feeling, affect sexual love both sides' pleasant sensation, and then affect sexual love harmony each other, when serious, affect people's libido.
The 3rd, after methyl-silicone oil and contact skin, be difficult to be cleaned, particularly friction can cause in its fold that enters vagina, makes it more be difficult to clean, and the dirt of prolonged stay in fold easily nourishes antibacterial, will affect women's healthy reproduction.Severe patient can cause various gynaecopathias, finally may cause sterility and infertility.
The 4th, methyl-silicone oil assists the safety of condom prevention of STD virus also to have defect.Scientific research demonstration, condom intercept the mortality of acquired immune deficiency syndrome (AIDS) leakage up to more than 30%.In a single day because silicone oil is bonded at skin, be difficult to clean, in sexual love process so, have virus to reveal, will be sticked on skin by silicone oil, also can't wash away even rinse, so just increased the risk that sex desease virus is propagated.
Therefore, in today, use methyl-silicone oil by people, to be denounced as the lubricant of condom.
As the human body lubricants above shortcomings, people are devoted to develop water-soluble human body lubricants to replace silicone oil in recent years in view of silicone oil.Yet not all soluble oil all can be converted and make human body lubricants, because having determined it, the human body lubricants environment for use must meet the requirement of the following aspects: have concordance with human body fluid, vaginal mucosa is not had to zest, with the latex material of condom, chemical reaction not occurring, does not cause the reduction of condom intensity.Therefore at present for the material of water-soluble human body lubricants, also be confined to limited several.
CN101524562A discloses " a kind of soluble oil for human body reproductive organ ", it consists of glycerol 20%～30%, propylene glycol 25%～35%, hydroxyethyl-cellulose 0.5%～1%, to hydroxyl methyl formate 0.1%～0.2%, to hydroxyl propyl formate 0.05%～0.1%, surplus is pure water.Wherein glycerol, propylene glycol are the main body compositions as moisturizing and increase lubricity, hydroxyethyl-cellulose plays thickening power, methyl parahydroxybenzoate (methyl hydroxybenzoate), hydroxyl propyl formate (propylparaben) being played to antisepsis, is mainly the preservation that is beneficial to lubricant itself.This soluble oil function is relatively simple, belongs to the most basic a kind of human body lubricants, only has moisturizing, lubrication.But propylene glycol has slight sensitization, methyl parahydroxybenzoate, undesirable to the dissolubility of hydroxyl propyl formate in water, therefore easily separate out.
CN101332317 discloses " a kind of water-soluble human body lubricants ", also to using glycerol and propylene glycol as moisturizing and Lubrication Composition, using hydroxyethyl-cellulose, carbomer 934 as viscosifier, and methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, chlorhexidine gluconate, two imidazolidinyl urea are made antiseptic.But methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben are difficult in water molten, in order to regulate pH value, be faintly acid in addition, also add acetic acid or citric acid pH value regulator, and add water solublity Herba Menthae brain to produce refrigerant sense.CN101327346 disclosed " a kind of water-soluble human body lubricants " compares with the human body lubricants of CN101332317, is to replace water solublity Herba Menthae brain with Polyethylene Glycol, can produce slight burning sensation with the Polyethylene Glycol water suction.This human body lubricants, except having basic moisturizing lubrication, can also bring cool or hot sensation, has strengthened the pleasant sensation of sexual life.Yet the propylene glycol in its raw material, acetic acid, citric acid all belong to has certain irritating material to mucosa, and vagina surface is mucosal tissue.
CN1544100A disclosed " water-soluble human body lubricants ", dewater and glycerol, propylene glycol, hydroxyethyl-cellulose viscosifier, antiseptic (methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, chlorhexidine gluconate, two imidazolidinyl urea are made antiseptic) and pH adjusting agent (acetic acid and citric acid) outside, also being added with the water solublity Aloe powder that adopts nanofiltration membrane separation concentrated, is mainly to utilize its antiinflammation.And why using this Aloe powder and without Aloe juice, be because the hapten material in Aloe juice can cause allergic reaction, and the moisture content in Aloe original juice can not have excellent lubricant effect.
CN101773513A disclosed " natural antibacterial components and with pH value consistence with pH value of vagina type water-soluble human body lubricants ", to using glycerol and propylene glycol as moisturizing and Lubrication Composition equally, hydroxyethyl-cellulose is as viscosifier, also propose to add hyaluronic acid, various possible nutritional labeling, such as comprising pectin decomposer, protamine, chitosan, lysozyme, nisin, agar oligosaccharide, its enzyme of sodium element, Radix Glycyrrhizae extract, Folium Camelliae sinensis extract, Folium Ginkgo extract etc., and think that various water-soluble human body lubricants are also applicable.Yet it is only a kind of imagination of inventor in essence for the scheme that the document discloses, the scheme of a lot of process checking that it is simply enumerated industrially can't not applied.Being mainly manifested in the vagina surface is mucosa rather than skin, a lot of materials of enumerating in the document can produce to stimulate to vaginal mucosa and cause anaphylaxiss such as not accommodating inflammation, and the performance that the composition had in addition also can destroy the condom latex causes strength decreased and can't apply at all.But in the document, do not provide again solution to the problems described above.
All in all, the technology of current water-soluble human body lubricants is all more approaching, its chief component is water and polyhydric alcohol, polyhydric alcohol is mainly to use simultaneously with two or three in glycerol, propylene glycol, ethylene glycol, be added with in addition viscosifier, antiseptic, and the pH value regulator, reach the most basic aqueous lubricating, antiseptic and inhibiting bacteria function and the faintly acid compatible with vagina, be satisfied with the most basic lubrication needs.And a small amount of interpolation water-solubility function composition is arranged for example, with enhancement life sensation, Mentholum, Polyethylene Glycol.Products material and function are also more single, generally all tasteless.In addition, owing to having adopted propylene glycol, acetic acid and citric acid etc. itself to belong to the material that mucosa is had to the minimal irritation effect, and methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben are not soluble in water, are not therefore optimal water-soluble lubricating system.
In addition, affect life quality except vaginal dryness, also have slack vagina.No matter being dry and astringent or loose, is all due to vagina normal physiological tissue aging or physiological function is impaired causes, and also medicine or health product occur targetedly at present.
Summary of the invention
The problems referred to above for existing water-soluble human body lubricants existence, the invention provides a kind of nourishing type water-soluble human body lubricants, the above-mentioned defect that not only there is no silicone lubricant, and do not contain sensitizer, main is that contained nutrition can be nourished the vagina surrounding tissue, to recover and to keep the histiocyte physiologically active, maintain body health.
A kind of nourishing type water-soluble human body lubricants of the present invention, the Main Components that it contains and weight percentage are:
Glycerol: 30-45%, tween 20: 2-4%, hyaluronate sodium: 0.05-0.15%, luxuriant growth reed quintessence oil: 0.5-1.2%, orange blossom quintessence oil: 0.08-0.2%, Flos Rosae Rugosae quintessence oil 0.1-0.3%, water 50-61.15%.
More satisfactory is also to contain the Herba Lysimachiae foenum-graeci quintessence oil of 0.05-0.2%.
More satisfactory is also to contain the Fructus Citri Limoniae quintessence oil of 0.05-0.2%.
Hyaluronic acid, Fructus Citri Limoniae quintessence oil have good viscosity, have viscosifying action, can add hydroxyethyl-cellulose again.Certainly, further, also can add as required the hydroxyethyl-cellulose of 2-4%, with adjusting viscosity.
The present invention also provides the preparation method of above-mentioned nourishing type water-soluble human body lubricants, adopts following method preparation:
(1) glycerol and hyaluronate sodium are added in 65-75 ℃ of distilled water and stir to make its even mixing, make water.
(2) various quintessence oils are mixed homogeneously with tween 20, make oil phase.
(3) stirring oil phase limit in limit is added dropwise to water in oil phase, can first form w/o type emulsion, water continues to increase, emulsion is thickening gradually, continue to drip water emulsion and just suddenly send out rare, and be transformed into O/W type emulsion, continue remaining water is added, and finally obtain O/W type emulsion, be cooled to room temperature.
In described step (1), can also add hydroxyethyl-cellulose as required.
In described step (2), also can add the Herba Lysimachiae foenum-graeci quintessence oil of 0.05-0.2% and/or the Fructus Citri Limoniae quintessence oil of 0.05-0.2%.
The present invention also provides a kind of condom, it is characterized in that being coated with above-mentioned nourishing type water-soluble human body lubricants at the condom outer surface.
Plants essential oil is the distinctive aromatic substance of extraction plant, is taken from herbal flower, leaf, root, bark, fruit, seed, resin etc., with the plant essence distilled, the squeezing mode extracts.Plants essential oil contains the compositions such as alcohols, aldehydes, acids, phenols, acetone class, terpenes, and molecule is little, easily is absorbed by the body, and its volatility is easily distributed its fragrance.Quintessence oil is mainly used for air freshener at present to purify air or to sterilize, or cosmetics, shower product or therapeutic massage be for to the nursing of skin, or for perfume, fancy soap to adjust odor type.This nourishing type water-soluble human body lubricants of the present invention, adopt plants essential oil, and its characteristics are:
1, water-soluble human body lubricants employing water of the present invention is solution, and glycerol, tween 20 and hyaluronate sodium, hydroxyethyl-cellulose are water-soluble components, although a small amount of quintessence oil composition is oiliness, but what under the tween 20 effect, form is oil-in-water micro-drop emulsion, with the normal juice of human body, can dissolve each other, without greasy feeling, the convenient cleaning, user is more acceptant on sense organ.
2, the hyaluronic acid in raw materials used, the aqueous solution of tween 20 are faintly acid, and weakly acidic quintessence oil composition, therefore soluble oil of the present invention does not need additionally to add the pH value regulator and can keep faintly acid, this water-soluble human body lubricants acid-base value is consistent with vagina normal physiological environment pH value, can maintain the vagina acid-base balance, the sensitization of avoiding again present product to bring due to interpolation pH value regulator.
3, the plants essential oil that contains of this nourishing type soluble oil, can nourish protective effect to vagina.
Wherein, in the Aloe quintessence oil, containing the compositions such as abundant saccharide, aminoacid, trace element, vitamin has good nutrition and moistens effect human body; Saccharide in Aloe and Amino acid profile natural Moisture factor, can supplement the moisture lost in human body, recover the function of collagen protein.Collagen protein has the water storage function and improves the effect of water metabolism, reduces cell injury, and anti-aging effects is arranged; In the Aloe quintessence oil, the poly glycuronate has the granulation of promotion growth, and slough is come off ahead of time.Aloe polysaccharide can reduce the high lipid peroxide level that the rat endotoxin is induced, and the oxygen free radical scavenger vitamin E that action effect is equivalent to generally acknowledge, show that it is at the removing oxygen-derived free radicals, delaying the aspects such as body aging has the medical value of good action Aloe to obtain globally admitting, result of study shows, the true border of Aloe dry powder granule non-toxic type; To gene, somatic cell and sexual cell without obvious mutagenic action, do not show obvious toxic-side effects, Aloe extract carries out Antibacterial Activity to several frequently seen microorganism, result shows the Aloe extract growth of anti-bacteria effectively, can be used for various dermatitis, as blepharitis, conjunctivitis, vasculitis, female sex organs inflammation etc.
Flos Rosae Rugosae quintessence oil is by some very little molecular compositions, easily sees through mucosal tissue for human body lubricants, by with being mixed in body of fatty fiber, strong and shrink blood capillary, can recover human body elasticity, strengthen the skin vigor, promote cell regeneration to put down and comfort, aging human body is had to splendid rejuvenation.But the Flos Rosae Rugosae quintessence oil available energy is adjusted female incretion, nourish uterus, relieving dysmenorrhea, improve frigidity and climacteric discomfort.Flos Rosae Rugosae quintessence oil, also have antibiotic, spasmolytic, sterilize, promote the sexual maturity, purify, calm, mend the body effect, maintain the physiological environment of vaginal health.
The orange blossom quintessence oil strengthens cell viability, helps cell regeneration, increases human body elasticity; Whitening, moisturizing, light speckle.Orange blossom is effective estrualization agent, and the problem of helping property aspect, also can improve dejected emotion, as premenstrual syndrome and involutional psychological problems.
In Fructus Citri Limoniae quintessence oil, be rich in abundant vitamin C, be particularly useful for whitening, convergence.But Fructus Citri Limoniae quintessence oil is the old dead cell in place to go also, the consolidation blood capillary, promote collagen protein to produce, and desalination melanin is obvious to women's nourishing effect.
Herba Lysimachiae foenum-graeci quintessence oil can heat-clearing and toxic substances removing, promotes damaged tissues regeneration, regulates and organizes oil-water balance and pH value.
For human body lubricants, and there is plants essential oil in the present invention with oil-in-water micro-drop form, phallic friction makes micro-drop can penetrate mucosal tissue by human body, to be absorbed fast, nourish health-care effect and produce when sexual love.
4, the glycerol water absorption is strong, has excellent moisturizing lubricant effect.Aqueous solution of sodium hyaluronate, have high viscoelasticity and profiling, moisturizing and lubrication, itself is exactly the biological active substances of human body, more superior as the compatibility, the lubricity of human body lubricants itself and human body.The Aloe quintessence oil has moistening effect equally.What Aloe quintessence oil etc. formed under the tween 20 effect is oil-in-water emulsion, forms the emulsion lubrication system.Its lubricant effect of soluble oil of the present invention is significantly improved than traditional oleaginous base lubricant.
5, the viscosity of hyaluronate sodium can hinder the diffusion of antibacterial, and Flos Rosae Rugosae quintessence oil has antibiotic, spasmolytic, bactericidal action; Aloe quintessence oil, Herba Lysimachiae foenum-graeci quintessence oil, Flos Rosae Rugosae quintessence oil have good antibacterial anti-inflammatory effect equally, therefore without adding indissoluble or the antiseptic such as methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben of stimulation, sensitization being arranged, help again preventive to spread disease simultaneously.And, owing to being water solublity, it can be developed when rinsing, avoid antibacterial to remain in intravaginal.
6, water-soluble human body lubricants of the present invention, have rose scent, particularly in the sexual life process due to friction, rose scent is denseer, not only changes the tasteless deficiency of conventional lubricant, and has and promote the sexual maturity, regulate the reproductive system effect; The effect of promoting the sexual maturity of Flos Rosae Rugosae quintessence oil, orange blossom quintessence oil can improve frigidity, improves pleasant sensation and the quality of sexual life.
7, Aloe quintessence oil, compare the zest composition not only do not had vagina with Aloe juice, compare except having fungistatic effect with the Aloe powder through nanofiltration separation, also has moisturizing, nutrition, promotion wound healing texts.Aloe quintessence oil good penetrability, not only itself do not have zest to vagina, and can also suppress the anaphylaxis that its group component produces.Hyaluronate sodium has the Vascular Permeability effect of regulating, and promotes water, electrolyte diffusion and running to promote wound healing, and main is and the same use of quintessence oil, can promote the absorption of quintessence oil, gives full play to the effect of quintessence oil.
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described, to help understanding content of the present invention.
As preferred embodiment, nourishing type water-soluble human body lubricants adopts following method preparation:
(1) glycerol, hydroxyethyl-cellulose (if necessary) and hyaluronate sodium are added in 65-75 ℃ of distilled water and stir to make its even mixing, make water.
(2) various quintessence oils are mixed homogeneously with tween 20, make oil phase.
(3) stirring oil phase limit in limit is added dropwise to water in oil phase, can first form w/o type emulsion, water continues to increase, emulsion is thickening gradually, but adds to after 66% at water, and emulsion is just suddenly sent out rare, and be transformed into O/W type emulsion, continuation faster adds remaining water, and finally obtains O/W type emulsion, is cooled to room temperature.This kind method is called phase conversion emulsifying, thus its granule of the emulsion that obtains of method disperse very thin, and evenly, stable.
Emulsion can be bottled, or is coated on condom.
Check
1 physical property
1.1 character
With the visual observation transparency.
1.2 viscosity
Under (20～22) ℃ condition, by rich power, fly LVDV-II type viscosimeter and measure its viscosity, adopt No. 16 rotor, rotating speed is 50rpm.
1.3 water solublity
Distilled water and lubricant are placed in to test tube with the ratio of 1: 1 and shake up, then range estimation should be without visible floccule under the light of 300LX.
1.4 fragrance
With olfactory sensation, differentiate.
1.5 lubricity
Randomly draw nourishing type soluble oil high-barrier condom and traditional silicon oil lubricant high-barrier condom, it is positioned over to angle of inclination is that on the bright finish inclined-plane of 45 °, chamfer length is 200cm.Allow the high-barrier condom in the down free landing of the top on inclined-plane, calculate it and be slipped to the required time of bottom, inclined-plane, parallel testing 10 times, calculate its meansigma methods.The methyl-silicone oil high-barrier condom time is 7.2s, and the nourishing type soluble oil high-barrier condom time is in Table 1.
As can be seen from Table 1,5 embodiment lubricities of human body lubricants of the present invention all are better than the methyl-silicone oil human body lubricants.
1.6 moisture retention
Take respectively formula each 5g of sample of 1～5, be placed in weighing botle, do not add a cover and be placed in simultaneously 29 ℃, relative humidity (RH) is, in 40% climatic chamber, every 15h, to take out weighing, calculates percentage of water loss (SI).Percentage of water loss is lower, shows that its performance of keeping humidity is better.
Percentage of water loss (SI) %=(W1-W2)/(W1-W) * 100
W1: the weight of sample before experiment
W2: the weight of sample after specific time interval
W: the weight of weighing botle
As can be seen from Table 1, nourishing type human body lubricants moistening effect of the present invention is good.
2 chemical properties
2.1 acid-base value
The mensuration of water-soluble human body lubricants pH value: should measure by the method for appendix A, it is qualified that pH value is considered as 5.0～8.0.
2.1.1 reagent laboratory water: adopt three grades of water in GB/T6682, wherein electrical conductivity is less than or equal to 5 μ S/cm, cooling with before boiling.
2.1.2 instrument
PH meter: comprise temperature compensation system, precision is at least 0.02.
Glass electrode, calomel electrode or combination electrode.
2.1.3 method
(1) take water-soluble human body lubricants sample a (being accurate to 0.1g), add through boiling nine parts of cooled laboratory waters, be heated to 40 ℃, and constantly stir 10～15min, to evenly, be cooled to 25 ℃ of set points of temperature, stand-by.
(2) temperature of electrode, slurry and standard buffer solution need be adjusted to set point of temperature, and temperature is more approaching better to each other, or is adjusted to simultaneously the room temperature correction.
After instrumental correction, at first with experimental water, rinse electrode, then with filter paper, blot.Electrode is carefully inserted in sample, make the electrode submergence, treat the pH meter stable reading, record reading.Read to finish, need thorough cleaning electrode, stand-by.
As can be seen from Table 1, nourishing type human body lubricants of the present invention is faintly acid, consistent with vaginal environment.
2.2 vaginal irritation test
With reference to prescriptive procedure in GB/T16886.10-2011, test, the vaginal irritation index is not more than 4.
As can be seen from Table 1, nourishing type human body lubricants vaginal irritation index of the present invention is 0, shows non-stimulated.
2.3 sensitization test
With reference to prescriptive procedure in GB/T16886.10-2011, test, should be without sensitivity response.
As can be seen from Table 1, nourishing type human body lubricants of the present invention is without sensitivity response.
2.4 microbial limit
Press 2010 editions two appendix XIJ microbial limit test of Chinese Pharmacopoeia, the bacterial population of water-soluble human body lubricants should be no more than 100cfu/ml; Fungi count and yeast count should be no more than 10cfu/ml; Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans must not detect.
2.5 bacteriostasis property test
In GB15979-2002 " disposable use hygienic article sanitary standard " appendix C, stripping property resists (pressing down) bacterium product bacteriostasis property test method, and the bacteriostasis property of water-soluble human body lubricants is tested.Water-soluble human body lubricants reply staphylococcus aureus (ATCC6538), escherichia coli (ATCC25922), Candida albicans (ATCC10231) has inhibitory action.
As can be seen from Table 1,5 embodiment of the present invention all have fungistatic effect.
2.6 explosion volume and pressure
For whether the check water-soluble human body lubricants affects its mechanical performance for after condom, carry out condom explosion volume and pressure test
With reference to the guide of the guidance in GB GB7544-2009/ISO4074:2002 and analysis accelerated ageing research, choose one group of aging condition, be equivalent to the condition of assessment storage life under selected climate temperature.Carry out aging purpose and be in order to observe and to reappear when the high-barrier condom carries out stability study under 30 ℃ the failure mode indicated.A collection of product is placed in to the ageing oven of 70 ± 2 ℃ and carries out agingly, 300 of number of samples, ageing time are 42 days, and its criterion is with reference to the sampling standard of GB/T2828-2003.
The method of testing of explosion volume and pressure: sample is bright finish width 52 ± 2mm, length 170mm, thickness 0.65 ± 0.015mm water-soluble human body lubricants condom, should guarantee that it is not subjected to excessive extension in any direction while launching soluble oil high-barrier condom.Hang the soluble oil high-barrier and be placed on round bar safely, and be fixed on fixture.The careful clamping ring of placing is on fixture, in order to avoid damage or extension soluble oil high-barrier condom are with (0.4～0.5) dm
3/ s[(24～30) dm
3/ min] inflation rate inflate.Check and be sure of that soluble oil high-barrier condom is swelling and do not having any obvious seepage.If there is any obvious seepage in soluble oil high-barrier condom, or in gas replenishment process, to leak air be termination test, thinks that this soluble oil high-barrier condom is defective, and its explosion volume and pressure all are designated as zero.If soluble oil high-barrier condom is air tight, measure and record explosion volume and pressure.The explosion volume means with cubic decimeter, changes whole to 0.5dm
3Burst pressure, with a kPa expression, is changed whole to 0.05Pa.Index request, aging front and back burst pressure all>=1.0kpa, the destruction capacity all>=18dm
3.
As can be seen from Table 1, nourishing type human body lubricants of the present invention is for condom, and still protection is higher at explosion volume and burst pressure after aging, the condom mechanical performance is not exerted an influence.
2.7 the scavenging action to DPPH
DPPH free radical analytic process is a kind of short-cut method that screens free radical scavenger, and application is more widely arranged abroad.The method can be measured the oxidation resistance of material, and the similar process that the aging of human body and ferrum get rusty is all the result of free-radical oxidation effect.In the environment that we live every day, the various factorss such as radiation, ultraviolet, waste gas all can cause the interior free yl surplus.Superfluous free radical meeting oxidation cell, accelerate apoptosis, causes the organ aging, thereby accelerate the aging of body, and bring out various diseases.Oxidation is a key factor of human body cell aging, can effectively remove free radical, and slowing down cellular oxidation is a kind of effective ways that slow down cell ageing.
2.7.1 material: hexichol is for bitterness diazanyl free radical (DPPH): Tokyo HuaCheng Industry Co., Ltd, with the analytical pure dehydrated alcohol, prepare; Tertiarybutylhydroquinone (TBHQ): Tokyo HuaCheng Industry Co., Ltd, food stage; Nourishing type soluble oil (self-control); Methyl-silicone oil.
2.7.2DPPH removing: to 2.5ml65 μ mol/L DPPH solution kind, add the 0.5ml sample, cumulative volume 3ml respectively.Blank replaces with the equivalent dehydrated alcohol, firmly shake up, after under room temperature, placing 30min, measure the reduction of DPPH mixed liquor at 517nm place light absorption value (A517) in optical path 1cm cuvette, with 2.5ml ethanol and 0.5ml sample mixed liquid demodulating apparatus zero point, with the impact of deduction sample intrinsic colour.
Suppression ratio (%)=(the p-A sample of A)/A is to * 100
As can be seen from Table 1, nourishing type human body lubricants of the present invention has effect of scavenging radical, illustrates and truly has the defying age effect.
The water-soluble human body lubricants of table 1 different component forms and result of the test
Claims (10)
1. nourishing type water-soluble human body lubricants, the Main Components that it contains and weight percentage are: glycerol: 30-45%, tween 20: 2-4%, hyaluronate sodium: 0.05-0.15%, luxuriant growth reed quintessence oil: 0.5-1.2%, orange blossom quintessence oil: 0.08-0.2%, Flos Rosae Rugosae quintessence oil 0.1-0.3%, water 50-61.15%.
2. nourishing type water-soluble human body lubricants as claimed in claim 1, is characterized in that, also contains the Herba Lysimachiae foenum-graeci quintessence oil of 0.05-0.2%.
3. nourishing type water-soluble human body lubricants as claimed in claim 1, is characterized in that, also contains the Fructus Citri Limoniae quintessence oil of 0.05-0.2%.
4. nourishing type water-soluble human body lubricants as claimed in claim 2, is characterized in that, also contains the Fructus Citri Limoniae quintessence oil of 0.05-0.2%.
5. as described nourishing type water-soluble human body lubricants one of in claim 1 to 4, it is characterized in that, also contain the hydroxyethyl-cellulose of 2-4%.
6. the preparation method of the described nourishing type of claim 1 water-soluble human body lubricants, adopt following method preparation:
(1) glycerol and hyaluronate sodium are added in 65-75 ℃ of distilled water and stir to make its even mixing, make water;
(2) various quintessence oils are mixed homogeneously with tween 20, make oil phase;
(3) stirring oil phase limit in limit is added dropwise to water in oil phase, can first form w/o type emulsion, water continues to increase, emulsion is thickening gradually, continue to drip water emulsion and just suddenly send out rare, and be transformed into O/W type emulsion, continue remaining water is added, and finally obtain O/W type emulsion, be cooled to room temperature.
7. preparation method as claimed in claim 6, it is characterized in that: in described step (1), also add hydroxyethyl-cellulose, addition is the 2-4% of lubricant total amount.
8. preparation method as claimed in claim 6, is characterized in that: also add the Herba Lysimachiae foenum-graeci quintessence oil of 0.05-0.2% and/or the Fructus Citri Limoniae quintessence oil of 0.05-0.2% in described step (2).
9. condom, one of is characterized in that in the condom surface is coated with claim 1 to 4 described nourishing type water-soluble human body lubricants.
10. a condom, is characterized in that being coated with on the condom surface the described nourishing type of claim 5 water-soluble human body lubricants.
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| CN107789304A (en) * | 2017-10-31 | 2018-03-13 | 福建师范大学 | A kind of sodium hyaluronate lubricating fluid and preparation method thereof |
| CN107811958A (en) * | 2017-10-31 | 2018-03-20 | 福建师范大学 | A kind of fermented tea fermentation lubricating fluid and preparation method thereof |
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| CN105999426A (en) * | 2016-07-26 | 2016-10-12 | 广东诺丝科技股份有限公司 | Hyaluronan water-soluble human body lubricating liquid |
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| CN105999426B (en) * | 2016-07-26 | 2019-01-29 | 广东诺丝科技股份有限公司 | A kind of hyaluronic acid water-soluble human body lubricating fluid |
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| CN106421935A (en) * | 2016-08-12 | 2017-02-22 | 古巧渝 | Water-soluble condom lubricating liquid |
| CN106730042A (en) * | 2017-01-17 | 2017-05-31 | 张天宇 | A kind of preparation method of low-residual hyaluronic acid matrix human body lubricants |
| CN107789304A (en) * | 2017-10-31 | 2018-03-13 | 福建师范大学 | A kind of sodium hyaluronate lubricating fluid and preparation method thereof |
| CN107811958A (en) * | 2017-10-31 | 2018-03-20 | 福建师范大学 | A kind of fermented tea fermentation lubricating fluid and preparation method thereof |
| CN107789304B (en) * | 2017-10-31 | 2020-08-11 | 福建师范大学 | Hyaluronic acid lubricating liquid and preparation method thereof |
| CN108939171A (en) * | 2018-08-03 | 2018-12-07 | 孙廷柱 | A kind of soluble condom and its production method with koro function |
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