CN103340917A - Extraction method for flavonoids in mugwort - Google Patents
Extraction method for flavonoids in mugwort Download PDFInfo
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- CN103340917A CN103340917A CN2013102574148A CN201310257414A CN103340917A CN 103340917 A CN103340917 A CN 103340917A CN 2013102574148 A CN2013102574148 A CN 2013102574148A CN 201310257414 A CN201310257414 A CN 201310257414A CN 103340917 A CN103340917 A CN 103340917A
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- radix artemisia
- artemisia ordosicae
- flavonoid substances
- extracting method
- ordosicae
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Abstract
The invention relates to an extraction method for flavonoids in mugwort, which is characterized by comprising the following steps of: (1), smashing, (2), degreasing and decoloring; (3), extraction: allowing the obtained degreased mugwort powder in the step (2) to be subjected to percolation at the temperature of 70 DEG C in 60-80 percent ethanol, so as to obtain an extract, and spray drying, thereby obtaining the flavonoids. The method is simple in technology, and easy to industrialize; and moreover, the product is high in purity (not less than 98 percent), and mugwort oil or chlorophy11 can be directly extracted from the degreased and discolored liquid.
Description
[technical field]
The present invention relates to the Radix Artemisia ordosicae technical field, specifically, is the extracting method of Flavonoid substances in a kind of Radix Artemisia ordosicae.
[background technology]
Radix Artemisia ordosicae is a kind of herbaceos perennial, is distributed in Asia and European Region.Folium Artemisiae Argyi makes the moxibustion material, and dredge the meridian passage is arranged, and dispels YIN-cold, dispersing swelling and dissipating binds, effects such as recuperating depleted YANG and rescuing the patient from collapse.Modern pharmacology finds that Folium Artemisiae Argyi volatile oil content is many, 1.8-cineole (accounting for more than 50%), and other have α-absinthol, sesquiterpene alcohols and ester thereof.
The chemical compound that flavone compound (flavonoids) is that a class is present in is natural, have 2-phenyl chromone structure.
Flavone compound is widely distributed, has multiple biological activity.As: cardiovascular system activity, antibiotic and antiviral activity, anti-tumor activity, resisting oxidation free radical activity, antiinflammatory, analgesic activities, liver-protecting activity, in addition, studies show that in a large number that flavone compound also has blood pressure lowering, blood fat reducing, defying age, raising immunity of organisms, rushes down down, antitussive, eliminate the phlegm, pharmacologically actives such as spasmolytic and resistance attitude.
Flavones content is higher in the Radix Artemisia ordosicae, and traditional extracting method is direct with 60～80% ethanol or methanol extraction, but owing to oil substances in the Radix Artemisia ordosicae is more, also has a large amount of chlorophylls to separate out simultaneously, and impurity is more in the flavone of extraction, and yield is very low.
[summary of the invention]
The objective of the invention is to overcome the deficiencies in the prior art, the extracting method of Flavonoid substances in a kind of Radix Artemisia ordosicae is provided.
The objective of the invention is to be achieved through the following technical solutions:
The extracting method of Flavonoid substances in a kind of Radix Artemisia ordosicae, its concrete steps are:
(1) pulverizes
Fresh Radix Artemisia ordosicae root is dried with top, pulverize the back and sieve with 20 mesh sieve, obtain the former powder of Radix Artemisia ordosicae;
(2) degreasing decoloring
The former powder of Radix Artemisia ordosicae that step (1) is obtained adds 8: 2 acetoneand ethyl acetate mixed liquor of volume proportion under 50 ℃ of temperature conditions, carry out degreasing decoloring with percolation, obtains degrease Chinese mugwort powder and contains Chinese mugwort extracts essential oil liquid;
(3) extract
The degrease mugwort powder that step (2) is obtained is 60～80% ethanol with volume fraction under 70 ℃ of temperature conditions, and percolation obtains extracting solution, after the spray drying, namely obtains Flavonoid substances.
The volume fraction of described ethanol is 70%.
Contain Chinese mugwort extracts essential oil liquid and can directly extract Radix Artemisia ordosicae quintessence oil or chlorophyll.
Compared with prior art, good effect of the present invention is:
(1) defat mixed liquor: acetoneand ethyl acetate mixed liquor (8: 2), defat, decolorizing effect are best, and gained flavonoids of artemisia argyi content, purity are the highest;
(2) skimming temp: 50 ℃, temperature raises, the flavone stripping, and yield reduces;
(3) the Radix Artemisia ordosicae granular size is 20 orders.Granule is unfavorable for that for a short time percolation extracts, and granule is unfavorable for degreasing decoloring greatly;
(4) the technology of the present invention is simple, is easy to industrialization, products obtained therefrom purity height (low by dried 96%), and the liquid after defat, the decolouring can directly extract Radix Artemisia ordosicae quintessence oil or chlorophyll.
[description of drawings]
The different degreasing decoloring temperature of Fig. 1 are extracted flavone effect comparison diagram.
[specific embodiment]
The specific embodiment of the extracting method of Flavonoid substances in a kind of Radix Artemisia ordosicae of the present invention below is provided.
The extracting method of Flavonoid substances in a kind of Radix Artemisia ordosicae, its concrete steps are:
(1) pulverize:
Fresh Radix Artemisia ordosicae root is dried with top, pulverize the back and sieve with 20 mesh sieve, obtain the former powder of Radix Artemisia ordosicae;
(2) degreasing decoloring:
The former powder of Radix Artemisia ordosicae that step (1) is obtained adds 8: 2 acetoneand ethyl acetate mixed liquor of volume proportion under 50 ℃ of temperature conditions, carry out degreasing decoloring with percolation, obtains degrease Chinese mugwort powder and contains Chinese mugwort extracts essential oil liquid;
(3) extract:
The degrease mugwort powder that step (2) is obtained is 60～80% ethanol with volume fraction under 70 ℃ of temperature conditions, and percolation obtains extracting solution, and spray drying gets final product, and namely obtains Flavonoid substances.
Fig. 1 is that different degreasing decoloring temperature are extracted flavone effect comparison diagram, and visible skimming temp is 50 ℃, its best results.
Several solvent degreasing decolorizing effects of table 1 relatively
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, without departing from the inventive concept of the premise; can also make some improvements and modifications, these improvements and modifications also should be considered within the scope of protection of the present invention.
Claims (5)
1. the extracting method of Flavonoid substances in the Radix Artemisia ordosicae is characterized in that concrete steps are:
(1) pulverizes
(2) degreasing decoloring
(3) extract
The degrease mugwort powder that step (2) is obtained under 70 ℃ of temperature conditions is 60～80% ethanol with volume fraction, and percolation obtains extracting solution, after the spray drying, namely obtains Flavonoid substances.
2. the extracting method of Flavonoid substances in a kind of Radix Artemisia ordosicae as claimed in claim 1 is characterized in that, described pulverizing is pulverized the back and sieved with 20 mesh sieve for fresh Radix Artemisia ordosicae root is dried with top, obtains the former powder of Radix Artemisia ordosicae.
3. the extracting method of Flavonoid substances in a kind of Radix Artemisia ordosicae as claimed in claim 1, it is characterized in that, described degreasing decoloring adds 8: 2 acetoneand ethyl acetate mixed liquor of volume proportion for the former powder of Radix Artemisia ordosicae that step (1) is obtained under 50 ℃ of temperature conditions, carry out degreasing decoloring with percolation, obtain degrease Chinese mugwort powder and contain Chinese mugwort extracts essential oil liquid.
4. the extracting method of Flavonoid substances in a kind of Radix Artemisia ordosicae as claimed in claim 3 is characterized in that, contains Chinese mugwort extracts essential oil liquid and directly extracts Radix Artemisia ordosicae quintessence oil or chlorophyll.
5. the extracting method of Flavonoid substances in a kind of Radix Artemisia ordosicae as claimed in claim 1 is characterized in that, in step (3) was extracted, the volume fraction of described ethanol was 70%.
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| CN2013102574148A CN103340917A (en) | 2013-06-15 | 2013-06-15 | Extraction method for flavonoids in mugwort |
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| CN2013102574148A CN103340917A (en) | 2013-06-15 | 2013-06-15 | Extraction method for flavonoids in mugwort |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036897A (en) * | 2016-05-26 | 2016-10-26 | 惠州同富康生物科技有限公司 | Antioxidant health-care food composition containing green plums and preparation method thereof |
| CN106963797A (en) * | 2017-04-11 | 2017-07-21 | 洛阳泽达慧康医药科技有限公司 | A kind of method that extraction from folium artemisiae argyi prepares Chinese medicine antibacterial preparation |
| CN111184800A (en) * | 2020-03-01 | 2020-05-22 | 北京博爱堂中医药研究所 | Chinese medicinal preparation for inhibiting virus and fungus and activating immune system |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101264117A (en) * | 2008-04-25 | 2008-09-17 | 甘肃省商业科技研究所 | Mugwort flavone extracting technique and uses thereof |
| CN101791326A (en) * | 2009-09-09 | 2010-08-04 | 安徽海鑫中药饮片有限公司 | Method for extracting and purifying flavonoids of artemisia argyi |
-
2013
- 2013-06-15 CN CN2013102574148A patent/CN103340917A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101264117A (en) * | 2008-04-25 | 2008-09-17 | 甘肃省商业科技研究所 | Mugwort flavone extracting technique and uses thereof |
| CN101791326A (en) * | 2009-09-09 | 2010-08-04 | 安徽海鑫中药饮片有限公司 | Method for extracting and purifying flavonoids of artemisia argyi |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036897A (en) * | 2016-05-26 | 2016-10-26 | 惠州同富康生物科技有限公司 | Antioxidant health-care food composition containing green plums and preparation method thereof |
| CN106963797A (en) * | 2017-04-11 | 2017-07-21 | 洛阳泽达慧康医药科技有限公司 | A kind of method that extraction from folium artemisiae argyi prepares Chinese medicine antibacterial preparation |
| CN111184800A (en) * | 2020-03-01 | 2020-05-22 | 北京博爱堂中医药研究所 | Chinese medicinal preparation for inhibiting virus and fungus and activating immune system |
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Application publication date: 20131009 |