CN103285128A - Traditional Chinese medicine for treating bronchial asthma and preparation method thereof - Google Patents
Traditional Chinese medicine for treating bronchial asthma and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating bronchial asthma. The traditional Chinese medicine is prepared from the following medicines in mass fraction: 6 to 10 parts of ephedra, 3 to 6 parts of asarum sieboldii, 20 to 26 parts of gypsum, 4 to 8 parts of cassia twig, 10 to 12 parts of dried tangerine peel, 10 to 12 parts of semen lepidii, 20 to 30 parts of astragalus membranaceus, 20 to 30 parts of cortex mori radicis, 10 to 14 parts of fructus aurantii, 4 to 7 parts of radix aucklandiae, 10 to 14 parts of radix bupleuri, 10 to 14 parts of folium mori, 10 to 14 parts of honeysuckle, 8 to 12 parts of flos farfarae, and 8 to 12 parts of folium eriobotryae, wherein the ephedra is fried in advance, and the gypsum is raw gypsum. The preparation method comprises the following steps of: preparing each traditional Chinese medicine according to a prescription, wherein the ephedra is fried in advance; drying all the medicines and crushing into pieces; sterilizing; repeatedly decocting with water at three times; filtering and preparing into an extract; drying with medium heat; crushing and grinding into powder; finally pressing into troches or filling into capsules to obtain the finished product. The traditional Chinese medicine is fast to become effect, reliable, safe to use and suitable for being used for treating a patient suffering from bronchial asthma.
Description
Technical field
The present invention relates to pharmaceutical composition, in particular to the medicine that with the Chinese crude drug is the treatment bronchial asthma of preparation of raw material.
Background technology
Bronchial asthma (abbreviation asthma) is a kind of commonly encountered diseases, frequently-occurring disease.At present, about 300,000,000 people of global asthmatic patient, Chinese asthmatic patient about 3,000 ten thousand.Asthma is to influence the able-bodied important diseases of people.Treat untimelyly, lack of standardization, asthma may be fatal.The risk factor of asthma morbidity comprises host factor (inherited genetic factors) and two aspects of environmental factors, but most of asthmatic patient belongs to allergic constitution.The clinical manifestation of asthma is divided into acute attack stage, chronic duration and clinical relieving period, acute attack, and giving treatment to may be fatal when untimely.Doctor trained in Western medicine adopts control medicine and cushion treatment.
China has accumulated rich experience over thousands of years aspect treatment bronchial asthma.In recent years, had many treatment bronchial asthmas the Chinese medicine formula application patent of invention, for example No. 200510114645.9 " a kind of compound Chinese medicinal preparation for the treatment of asthma and preparation method thereof ", number 200710116197.5 " a kind of Chinese medicine that is used for the treatment of bronchial asthma for oral administration ", number 200910231514.7 " a kind of Chinese medicine unguentum for the treatment of bronchial asthma ", number 201010221755.6 " a kind of Chinese medicine composition for the treatment of bronchial asthma ", number 201110372302.8 " a kind of Chinese medicine for the treatment of bronchial asthma ", number 201210409375.4 " a kind of Chinese medicine decoction for the treatment of bronchial asthma and preparation method thereof " etc.The prescription of above-mentioned patent application has nothing in common with each other, and therapeutic effect also is not quite similar.In medical practice, in general, that the traditional Chinese medical science is cured the disease is effective, have no side effect substantially.Therefore people continue to excavate Chinese material medicine resource, develop more efficiently medicine.
Summary of the invention
Purpose of the present invention just is to provide a kind of Chinese medicine for the treatment of bronchial asthma, increases the types of drugs for the treatment of bronchial asthma, makes the patient remove the puzzlement of asthma, gets well.
Another object of the present invention provides this preparation method of Chinese medicine.
The Chinese medicine for the treatment of bronchial asthma of the present invention is formulated by following medical material, and their quality proportioning is:
Herba Ephedrae 6～10, Herba Asari 3～6, Gypsum Fibrosum 20～26, Ramulus Cinnamomi 4～8, tangerine 10～12, Semen Lepidii (Semen Descurainiae) 10～12, the Radix Astragali 20～30, Cortex Mori 20～30, Fructus Aurantii 10～14, the Radix Aucklandiae 4～7, Radix Bupleuri 10～14, Folium Mori 10～14, Flos Lonicerae 10～14, Flos Farfarae 8～12, Folium Eriobotryae 8～12; The parch in advance of described Herba Ephedrae, described Gypsum Fibrosum are given birth to and are used.
The optimization formula of this Chinese medicine is:
Herba Ephedrae 8, Herba Asari 5, Gypsum Fibrosum 22, Ramulus Cinnamomi 6, dried tangerine peel 11, Semen Lepidii (Semen Descurainiae) 11, the Radix Astragali 25, Cortex Mori 25, Fructus Aurantii 12, the Radix Aucklandiae 6, Radix Bupleuri 12, Folium Mori 12, Flos Lonicerae 12, Flos Farfarae 10, Folium Eriobotryae 10; The parch in advance of described Herba Ephedrae, described Gypsum Fibrosum are given birth to and are used.
In the above-mentioned Chinese medicine,
Herba EphedraeFor Ephedraceae plant plait Herba Ephedrae (
Ephedra sinica) herb stem, the acrid in the mouth hardship, warm in nature, can diaphoresis, relieving asthma diuretic (see the new medical college in Jiangsu compile " Chinese medicine voluminous dictionary " 2221 pages);
Herba AsariFor Fructus Aristolochiae plant Herba Asari (
Asarum sieboldii) whole herb with root, acrid in the mouth, warm in nature, can dispel the wind, cold expelling, Hang Shui, have one's ideas straightened out (seeing " Chinese medicine voluminous dictionary " 1477 pages);
Gypsum Fibrosum, for the Sulfates mineral gypsum (
Cypsum) Ore, acrid-sweet flavor, cold in nature, expelling pathogenic factors from muscles for clearing heat, relieving restlessness quench the thirst (seeing " Chinese medicine voluminous dictionary " 592 pages);
Ramulus CinnamomiFor the canella Cortex Cinnamomi (
Cinnamomum cassia) twig, acrid-sweet flavor, warm in nature, can diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation (seeing " Chinese medicine voluminous dictionary " 1771 pages);
TangerineFor the rutaceae tangerine produced in fujian province (
Citrum tangerina) or Zhu's Fructus Citri tangerinae (
Citrum erythrosa) outer red part, the acrid in the mouth hardship, warm in nature, can expectorant, promoting the circulation of QI, alleviating distention in middle-JIAO, eliminating stagnation (seeing " Chinese medicine voluminous dictionary " 2639 pages);
Semen Lepidii (Semen Descurainiae)For the crucifer Lepidium sativum L. (
Lepidium apetalum) seed, the acrid in the mouth hardship, cold in nature, the effect (seeing " Chinese medicine voluminous dictionary " 2319 pages) of therapeutic method to keep the adverse QI flowing downwards row water is arranged;
The Radix AstragaliFor the leguminous plant Radix Astragali (
Astragalus membranaceus) root, sweet in the mouth, slightly warm in nature, can stomach reinforcing consolidating superficial resistance, inducing diuresis to remove edema, invigorating the spleen and replenishing QI (seeing " Chinese medicine voluminous dictionary " 2036 pages);
Cortex MoriFor the moraceae plants Mulberry (
Morus alba) remove the root bark of cork, sweet in the mouth, cold in nature, eliminating pathogen from the lung for relieving asthma is arranged, the effect of line water detumescence (seeing " Chinese medicine voluminous dictionary " 1968 pages);
Fructus AurantiiFor the rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) (
Poncirus trifoliata) mellow fruit nearly, cool in nature, the bitter in the mouth suffering can dispelling the stagnated QI, removing food stagnancy (seeing " Chinese medicine voluminous dictionary " 1507 pages);
The Radix AucklandiaeFor the feverfew Saussurea lappa Clarke (
Saussurea lappa) root, the acrid in the mouth hardship, warm in nature, can circulation of qi promoting, pain relieving, warming middle-JIAO for easing the stomach (seeing " Chinese medicine voluminous dictionary " 353 pages);
Radix BupleuriFor the samphire Radix Bupleuri (
Bupleurum chinense) root, bitter in the mouth, cool in nature, reconciling superficies and interior, soothing the liver yang invigorating effect (seeing " Chinese crude drug voluminous dictionary " 1832 pages) are arranged;
Folium MoriFor the moraceae plants Mulberry (
Morus alba) leaf, bitter but sweet flavor, cold in nature has expelling wind and clearing away heat, cooling blood for improving eyesight effect (seeing " Chinese medicine voluminous dictionary " 1963 pages);
Flos LoniceraeFor caprifoliaceae plant Radix Ophiopogonis (
Lonicera japonica) alabastrum, sweet in the mouth, cold in nature, can heat-clearing and toxic substances removing (seeing " Chinese medicine voluminous dictionary " 1403 pages);
Flos FarfaraeFor the feverfew coltsfoot (
Tussilago farfara) alabastrum, acrid in the mouth, warm in nature, can nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing (seeing " Chinese medicine voluminous dictionary " 2301 pages);
Folium EriobotryaeFor the rosaceous plant Folium Eriobotryae (
Eriobotrya japonica) leaf, bitter in the mouth, cool in nature, the effect (seeing " Chinese medicine voluminous dictionary " 1248 pages) of lung heat clearing stomach function regulating, lowering the adverse-rising QI to resolve phlegm is arranged.
Above-mentioned medical material should meet " the regulation in one one of the Chinese pharmacopoeia nineteen ninety-five version under each medical material item.
The preparation method of Chinese medicine for the treatment of bronchial asthma of the present invention is to be equipped with medicine by the Chinese medicine of respectively distinguishing the flavor of in the prescription, and wherein, Herba Ephedrae was processed in advance; Again with above-mentioned whole medicines oven dry, in flakes broken, the reuse disinfection by ultraviolet light is put into pottery or copper jar or copper utensil (should not use iron pan) and is added water and decoct repeatedly 3 times, 1～2 hour for the first time, 0.5～1 hour for the second time, 0.5 hour for the third time, filter and make extractum; 60 order powder are pulverized, are ground to form in fire drying in the reuse; Pharmaceutical technology routinely at last is pressed into tablet or incapsulates, and every 1g or every 1g namely get tablet or capsule.Product should meet " the requirement in one one of the Chinese pharmacopoeia nineteen ninety-five version.
The above-mentioned pharmaceutical technology that is pressed into tablet comprises: 1. the 60 order powder that make are added adjuvant, main adjuvant is the adhesive modified starch, mix homogeneously; 2. in mixed powder, add water as wetting agent, make soft material; 3. soft material extruding is sieved, make granule; 4. granule is through super-dry, make its moisture be fit to and evenly, grain graininess is suitable; 5. dried particles confirms to meet the requirement of tablet through check; 6. extrude tablet with Chong Yashi or rotary tablet machine, what be up to the standards is finished product.
The pharmaceutical technology of above-mentioned capsule comprises: 1. preparing or buying with the gelatin is the capsulae vacuus of primary raw material; The 60 order powder that 2. will make are crossed sieve No. 6, and the fine powder that obtains is standby; 3. go into soft capsule with the artificial medicated powder of loading, or with the automatic filling machine medicated powder of packing into; 4. effective ingredient and the quality of medicated powder are tested, seal at the capsule capping place with the glue of gelatin qualified back, obtains finished product.
The inventor points out: this Chinese medicine also can be prepared into any peroral dosage form commonly used with conventional method of Chinese medicinal.No matter which kind of dosage form all must be deposited according to the relevant regulations that medicine stores.
The usage of Chinese materia medica for the treatment of bronchial asthma of the present invention is oral, warm water delivery service, every day 2 times, each 4-5 grain.Also can add and subtract dose as one sees fit according to the state of an illness.
Clinical use result shows that this Chinese medicine is evident in efficacy, takes a few hours to get final product cough-relieving, control and breathe heavily; The bronochitic is made special effect, and effective percentage is more than 85%
The inventor successfully cured many bronchial asthma patients, and wherein more typical case has:
Case one: You Zhengrong, woman, 70 years old.The patient began to suffer from bronchial asthma in 1975, and for a long time with ephedrine Zhichuan, the back is because clenbuterol cough-relieving Zhichuan is just used in abusing and selling of state control ephedrine instead.Over nearly 5 years, because the age increases, clenbuterol has been difficult to solve bronchial asthma, takes medicine of the present invention after 1 month through changing into, and asthma obviously alleviates, and serve on 4 months asthma basic controlling, and health is obviously got well.
Case two: mother inventor Zhu Zhengying, woman, 78 years old.Once suffered from bronchitis=asthma for many years, life-time service hormone drug or aminophylline are alleviated, but medicine shows effect again after stopping.Began to take medicine of the present invention two months in 2006, asthma obviously alleviates, and serve on half a year, and symptom is controlled fully.
Case three: Gong Xuhua, man, 14 years old, Cha He people from town, Bijie City, Guizhou Province.Because often coughing, the patient pants, rale in the pharynx, and dyspnea, the vexed pain of fullness in the chest, thirsty vexed, be bronchial asthma through hospital diagnosis.Take medicine of the present invention after 5 days, breathe smooth and easyly, serve on 20 days, the disease recovery from illness was followed up a case by regular visits to after half a year, recurrence.
Chinese medicine of the present invention, curative effect rapidly, reliably use safety, are applicable to treatment bronchial asthma patient.
The specific embodiment
Embodiment 1
Be equipped with medicine by the Chinese medicine of respectively distinguishing the flavor of in the prescription, wherein, Herba Ephedrae was processed in advance; Again with above-mentioned whole medicines oven dry, in flakes broken, the reuse disinfection by ultraviolet light is put into the copper jar and is added water and decoct repeatedly 3 times, 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, filters and makes extractum; 60 order powder are pulverized, are ground to form in fire drying in the reuse; Pharmaceutical technology routinely is pressed into tablet at last, and every 1g namely gets the tablet product.
Embodiment 2
Preparation process is with embodiment 1.Grind to form 60 purpose drug powders, pharmaceutical technology routinely incapsulates at last, and every 1g namely gets the capsule product.
Claims (3)
1. a Chinese medicine for the treatment of bronchial asthma is characterized in that this Chinese medicine is formulated by following medical material, and their quality proportioning is:
Herba Ephedrae 6～10, Herba Asari 3～6, Gypsum Fibrosum 20～26, Ramulus Cinnamomi 4～8, tangerine 10～12, Semen Lepidii (Semen Descurainiae) 10～12, the Radix Astragali 20～30, Cortex Mori 20～30, Fructus Aurantii 10～14, the Radix Aucklandiae 4～7, Radix Bupleuri 10～14, Folium Mori 10～14, Flos Lonicerae 10～14, Flos Farfarae 8～12, Folium Eriobotryae 8～12; The parch in advance of described Herba Ephedrae, described Gypsum Fibrosum are given birth to and are used.
2. according to the described Chinese medicine of claim 1, it is characterized in that this Chinese medicine is formulated by following medical material, their quality proportioning is:
Herba Ephedrae 8, Herba Asari 5, Gypsum Fibrosum 22, Ramulus Cinnamomi 6, dried tangerine peel 11, Semen Lepidii (Semen Descurainiae) 11, the Radix Astragali 25, Cortex Mori 25, Fructus Aurantii 12, the Radix Aucklandiae 6, Radix Bupleuri 12, Folium Mori 12, Flos Lonicerae 12, Flos Farfarae 10, Folium Eriobotryae 10; The parch in advance of described Herba Ephedrae, described Gypsum Fibrosum are given birth to and are used.
3. the method for preparing one of claim 1 and 2 described Chinese medicine preparation is characterized in that being equipped with medicine by the Chinese medicine of respectively distinguishing the flavor of in the prescription, and wherein, Herba Ephedrae was processed in advance; Again with above-mentioned whole medicines oven dry, in flakes broken, the reuse disinfection by ultraviolet light is put into pottery or copper jar or copper utensil and is added water and decoct repeatedly 3 times, 1～2 hour for the first time, 0.5～1 hour for the second time, 0.5 hour for the third time, filters and makes extractum; 60 order powder are pulverized, are ground to form in fire drying in the reuse; Pharmaceutical technology routinely at last is pressed into tablet or incapsulates, and every 1g or every 1g namely get tablet or capsule.
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| CN103566157A (en) * | 2013-09-30 | 2014-02-12 | 尹雯雯 | Traditional Chinese medicine composition for treating asthma |
| CN104274605A (en) * | 2014-10-11 | 2015-01-14 | 中山百鸥医药科技有限公司 | Traditional Chinese medicine for treating bronchial asthma and preparation method thereof |
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