CN103230273B - The non-invasive detection system of early stage subclinical asymptomatic diabetes and method thereof - Google Patents
The non-invasive detection system of early stage subclinical asymptomatic diabetes and method thereof Download PDFInfo
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Abstract
The invention provides non-invasive detection system and the method thereof of early stage subclinical asymptomatic diabetes.Diabetes monitoring systems of the present invention comprises: power module, voltage reference module, electrod-array, adjustable resistance, switch arrays, measurement module, data processing module and analysis module.By after the resistance of anticipation experimenter human body and capacity effect equivalent resistance and anticipation actuation voltage range, the voltage of test electrode both positive and negative polarity and adjustable precision resistive voltage and resistance value also carry out date processing, obtain skin electricity biological parameter, to carry out the analysis of diabetes characteristics of lesion, thus export the test result comprising the judgement of diabetic phase scope and the assessment of risk size.The patient in subclinical or asymptomatic stage in early days is accurately detected in noninvasive mode.
Description
Technical field
The present invention relates to medical apparatus and instruments, relate generally to a kind of non-invasive detection system for early stage subclinical asymptomatic diabetes and detection method thereof.
Background technology
Along with the raising of people's living standard, diabetics is increasing, and diabetes and complication thereof bring spirit and economic burden greatly to patient.In fact, many potential patients of diabetes being in the reversible stage, if early can find early treatment, can stop it to develop into the irreversible clinical definite stage.Therefore, if the potential risk of the diabetes patient in subclinical or asymptomatic stage in early days accurately can be detected, bring glad tidings to the potential patient of vast diabetes.
Secondly physiological Study shows: during human body morbidity, and be first change from body fluid, cell starts change, until membranolysis, to degenerate, then further develops the organic pathological changes reaching clinical monitoring and arrive.The dysfunction initial stage, not organic pathological changes embodied, but from microcosmic point, and the change of form is synchronous with the change of function.
Clinic study shows: the pathological changes of diabetes can involve the pathological changes of autonomic nerve, wherein controls the sympathetic neuropathy of sweat gland clearly.Although early stage subclinical diabetes mellitus is clinically without any symptom, but its sympathetic nerve controlling sweat gland there occurs pathological changes, causes the fibrosis of sweat gland tissue, functional disorder.The resistance of its skin histology, capacity effect all can cause raw significantly change.Meanwhile, the fibrosis of sweat gland tissue, causes the electrochemical phenomena of perspiration also can change.Therefore, electro-detection method has been applied in the earlier detection of diabetes.
But traditional electro-detection method is all this incomplete cognition of a simple resistance based on human body, conventional impedance method detection mode, adopt the real part and imaginary part message reflection pathological characters that extract impedance spectrogram.Judge the order of severity of diabetics based on the fluorescence oblique fire method detection signal after the absorption of hands forearm AGEs, it is limited to weak output signal and is difficult to differentiate, and accuracy is not high.The feedback signal detecting electric current after adopting galvanic stimulation judges to there is same problem.
Experiment shows: human body has the characteristic of resistance and capacity effect simultaneously, and human body skin also possesses perspiration functions simultaneously, and the ion of perspiration also possesses specific electrochemical effect.Therefore, which kind of human body resistance model no matter Conventional impedance method detection mode adopt, and considers the different characteristic factor of extraneous factor and human body, accuracy exists many queries or strict tested condition.The factor that the method have ignored skin histology resistance because diabetic autonomic neuropathy causes, capacity effect obviously changes, the special delay phenomenon not having to consider because capacity effect causes in the processing method of human body equivalent resistance, testing result often differs greatly with clinical test results.
Under specified human-body safety DC voltage, the change of the resistance of human body is jumpy within the test time started, and its needs just can reach stable value for a long time.Be applied to the moment of human body at DC voltage, each cell of human body is equivalent to a small electric capacity, and the capacity effect of each cell is superimposed, and the Influence on test result of its effect to test be can not ignore.Therefore, Conventional impedance method detection mode is wanted to reach accurate result, can only lean on the time long enough of test, but this is again unrealistic in the middle of actual clinical, when particularly test needs the different DC voltage of applying just can complete.
Summary of the invention
There is provided content of the present invention to introduce some concepts will further described in following detailed description of the invention in simplified form.Content of the present invention is not intended to the key feature or the essential feature that identify theme required for protection specially, is not intended to the scope for helping to determine theme required for protection yet.
The present invention is based on human body resistance change at a dc voltage, capacity effect, the considering of electrochemical change, propose a kind of early stage subclinical asymptomatic non-invasive detection system and method for diabetes, possess quick, accurate, noninvasive feature.
Detection system of the present invention comprises: power module 105, voltage reference module 108, electrod-array 101, adjustable resistance 104, switch arrays 102, measurement module 103, data processing module 106 and analysis module 107.Power module 105 provides a specific DC voltage to each electrode of electrod-array 101; Voltage reference module 108 is for calibration voltage; Electrod-array 101 adopts the information of human body resistance, capacity effect and electrochemical effect test sensor electrode, is positioned over the position such as extremity or hand, chest, forehead, is close to skin surface; Adjustable resistance 104 is serially connected between power module 105 and electrode; By switch arrays 102 by some Electrode connection on power module 105; Measurement module 103 is for measuring the voltage and current of circuit; Data processing module 106, is connected to power module 105, switch arrays 102 and measurement module 103 and controls them, process, calculate and store simultaneously to the skin bioelectrical signals collected, and controls the frequency of sampling; Analysis module 107, connection data processing module 106, analyzes diabetes characteristics of lesion, and exports analysis result.
Detection method according to the present invention comprises the following steps: the resistance and the capacity effect equivalent resistance that walk anticipation experimenter human body through coarse adjustment and fine tuning two; Anticipation actuation voltage range; The voltage of test electrode both positive and negative polarity and adjustable precision resistive voltage and resistance value; Carry out date processing, obtain skin electricity biological parameter; Carry out the analysis of diabetes characteristics of lesion and output test result, comprising diabetic phase scope and risk size.
By reading detailed description of the invention also reference relevant drawings below, the features and advantages of the invention will be apparent.Be appreciated that foregoing summary and following detailed description of the invention are all illustrative, do not limit each side required for protection.
Accompanying drawing explanation
Fig. 1 is the block diagram of diabetes monitoring systems of the present invention.
Fig. 2 is the flow chart of diabetes detection method of the present invention.
Fig. 3 is current-voltage curve figure according to an embodiment of the invention.
Fig. 4 is the voltage-current curve graph of pair of electrodes according to an embodiment of the invention.
Fig. 5 is the voltage-current curve graph of two pairs of corresponding according to an embodiment of the invention electrodes.
Fig. 6 carries out to normal person, impaired glucose tolerance patients, diabetics the skin bioelectrical signals correlation curve figure that skin bio electricity Validity Test obtains according to the present invention.
Detailed description of the invention
The detailed description provided below in conjunction with accompanying drawing is intended to as the description to each example of the present invention, but not represents the unique forms for explaining or utilize each example of the present invention.
No matter be three element bio-impedance models, cole-cole is theoretical or frequency dispersion is theoretical all thinks that people carries cell membrane capacity and reduces along with the increase of frequency, and specific conductance raises with frequency and increases.When under DC case, be all fixed value, thus HFreiberger, RScherbaum, GBiegelmeier, Type Equivalent Circuit Model is all thought under DC case, human body resistance is considered as a non inductive resistor.But the applicant tests discovery, the human body impedance under low dc voltage and the linear relation of voltage.Capacity effect be can not ignore simultaneously.
Based on electrochemical appliances such as silver/silver chloride electrode, lithium electrode, nickel electrodes, be placed in epidermis, under the DC voltage being less than 10V, the ratio of electric current and voltage is not a steady state value, and electric current and voltage curve contain the information of human body resistance, capacity effect and electrochemical effect.Its performance curve forward part at lower voltages has human body resistance and capacity effect to determine, and after voltage increases, curve latter half be by the information of human body resistance, capacity effect and electrochemical effect three part determine.Particularly there is flex point latter half at curve, dominated by electrochemical effect.
Further, the vdct lower than 10V is given, some position of its health, such as: extremity, thoracic cavity portion, hand etc., impedance, compared with normal people, significantly changes.What this had been perfectly clear in SSR experiment shows: the pathological changes of diabetes can involve the pathological changes of autonomic nerve, wherein affects the most with the sympathetic nerve controlling sweat gland again.Cause the fibrosis of sweat gland tissue, antiperspirant pipe is inaccessible, and subcutaneous perspiration reduces, cuticle thickening.Thus human body resistance increases, electrochemical effect reduces.
Skin bioelectrical signals not only contains electrochemical effect and also comprises human body resistance and body capacity effect, and this phenomenon applies in the judgement of the order of severity of diabetes by the present invention, provides the diabetes monitoring systems that a kind of degree of accuracy is high.
As shown in Figure 1, this detection system comprises: power module 105, voltage reference module 108, electrod-array 101, adjustable resistance 104, switch arrays 102, measurement module 103, data processing module 106 and analysis module 107.
Power module 105 provides the DC voltage of a specific gradual change to each electrode of electrod-array 101, this voltage produces the driving voltage of skin bioelectrical signals as electrode, and the principle chosen is: voltage wave band must meet the appearance of human body resistance, capacity effect, electrochemical effect.Preferred DC voltage range is between 0 ~ 10V.This voltage is calibrated by voltage reference module 108.
Electrod-array 101 adopts the information of human body resistance, capacity effect and electrochemical effect test sensor electrode, and prepared by such as lithium material, ag material, nickel material with the sodium ion of perspiration, hydrion, chloride ion etc., the electrode of electrochemical reaction can occur under given voltage.The quantity of electrode, can form test sensor between every two electrodes mutually by usual 2 ~ 8.Be positioned over the position such as extremity or hand, chest, forehead, be close to skin surface.It will be understood by those skilled in the art that based on needs, can number of electrodes be increased and decreased.Meanwhile, for obtaining the enough large skin bioelectrical signals of intensity, the area of electrode is enough large, preferred area>=1cm
2.
For 4 electrodes: hand on the left of human body: L1; Hand on the right side of human body: L2; Foot on the left of human body: L3; Foot on the right side of human body: L4, can electrode test composed as follows order:
L1 ~ L2 or L2 ~ L1: investigate the skin bioelectrical signals (human body resistance change, capacity effect, electrochemical effect) of left side hand to right side hand;
L1 ~ L3 or L3 ~ L1: investigate the skin bioelectrical signals (human body resistance change, capacity effect, electrochemical effect) of left side hand to left side foot;
L1 ~ L4 or L4 ~ L1: investigate the skin bioelectrical signals (human body resistance change, capacity effect, electrochemical effect) of left side hand to right side foot;
L2 ~ L3 or L3 ~ L2: investigate the skin bioelectrical signals (human body resistance change, capacity effect, electrochemical effect) of right side hand to left side foot;
L2 ~ L4 or L4 ~ L2: investigate the skin bioelectrical signals (human body resistance change, capacity effect, electrochemical effect) of left side hand to right side foot;
L3 ~ L4 or L4 ~ L3: the skin bioelectrical signals (human body resistance change, capacity effect, electrochemical effect) investigating left side foot to right side foot;
And then can also form:
L1 ~ L3, L4 or L2 ~ L3, L4: investigate the skin bioelectrical signals (human body resistance change, capacity effect, electrochemical effect) of hand to foot;
L3 ~ L1, L2 or L4 ~ L1, L2: investigate the skin bioelectrical signals (human body resistance change, capacity effect, electrochemical effect) of foot to hand.
Adjustable resistance 104 is adjustable precision resistance, is serially connected between power module 105 and electrode, is obtained the electric current of circuit, also can be used to the equivalent resistance of testing human resistance and body capacity effect by the voltage of resistance and computing the resistor value.
By switch arrays 102 by some Electrode connection on power module 105, simultaneously other electrodes are in the pattern of disconnection.
Measurement module 103 is for measuring the electric current of circuit and voltage.For security consideration, measurement module 103 also can comprise protection circuit.In order to prevent interference, measurement module 103 also can possess anti-jamming circuit.In addition, based on the faint property of human body skin bioelectrical signals, measurement module 103 also can comprise possessing and to amplify the skin bioelectrical signals collected and circuit that A/D transforms.
Data processing module 106, is connected to power module 105, switch arrays 102 and measurement module 103 and controls them, process, calculate and store simultaneously to the skin bioelectrical signals collected, and controls the frequency of sampling.
Analysis module 107, connection data processing module 106, analyzes diabetes characteristics of lesion, and exports analysis result.
Fig. 2 is the flow chart of diabetes detection method of the present invention.Set forth for test electrode is combined as example with above-mentioned L1 ~ L2 below.
Resistance sizes and the capacity effect of different human body are different, therefore first in step 201, the resistance of anticipation experimenter human body and capacity effect equivalent resistance, object is that human body resistance change, capacity effect, electrochemical effect change in voltage are appeared within suitable scope, thus can be detected.Equivalent resistance realizes by regulating adjustable precision resistance.The scope of adjustable precision resistance is at 0 ~ 1M Ω, and precision is 100 Ω.
Due to the impact of capacity effect, the response of human body to the change of voltage has delay phenomenon and occurs, particularly when the amplitude that voltage changes is large.In order to the equivalent resistance of human body resistance and capacity effect more accurately can be obtained out, take first to carry out large-scale coarse adjustment, obtain one and carry out fine tuning more among a small circle.
Regulative mode is subdivided into coarse adjustment and fine tuning two steps:
First carrying out coarse adjustment, take L1 as anode, and L2 is negative electrode, and applying galvanic current pressure V, a V is the arbitrary value of 0 ~ 10V, in predetermined T time, with △ R
0amplitude, regulate the resistance of adjustable precision resistance, be reduced to 0 gradually from 1M Ω, wherein △ R
0depend on the applying voltage time t of time T and each step, the scope of T belongs to (10s ~ 300s), and the scope of t is at (0.5s ~ 3s), and data processing module 106 records the voltage of each step adjustable precision resistance.And the voltage finding out adjustable precision resistance is approximately the some U of the half of supply voltage
0, i.e. U
0≈ V/2, the resistance of now corresponding adjustable precision resistance is designated as R
0.Data processing module 106 is by (R
0+ R
0/ 2, R
0-R
0/ 2) as the scope of next step fine tuning.
Then carrying out fine tuning, take L1 as anode, and L2 is negative electrode, and apply a galvanic current pressure V, voltage is herein consistent with the voltage V of coarse adjustment, in the scheduled time T same with coarse adjustment, with the amplitude of △ R, regulates the resistance of adjustable precision resistance, from R
0+ R
0/ 2 are reduced to R gradually
0-R
0/ 2, wherein △ R depends on the applying voltage time t of time T and each step, and wherein t is consistent with the applying voltage time t of each step of coarse adjustment, and data processing module 106 records the voltage of each step adjustable precision resistance.And the voltage finding out adjustable precision resistance is the some U of the half of supply voltage, i.e. U=V/2, the resistance of now corresponding adjustable precision resistance is designated as R.
The resistance R of adjustable precision resistance stores by data processing module 106, and adjustable precision resistance R herein not only reflects the resistance of human body, also reflects the capacity effect of human body, and namely R is the equivalent resistance of human body resistance and electric capacity.
Between every pair of electrodes, human body resistance and the equivalent resistance of electric capacity are all through identical test, are stored the test resistance R of each pair of electrode by data processing module 106.In the anticipation actuation voltage range and testing procedure of follow-up often pair electrode, adjustable precision resistance is adjusted to the equivalent resistance R of counter electrode.
Then step 202 is entered, in this step anticipation actuation voltage range: take L1 as anode, L2 is negative electrode, adjustable precision resistance is the equivalent resistance R of corresponding L1 ~ L2 electrode, the DC voltage in anode 0 ~ 10V is given in the mode increased progressively gradually or successively decrease gradually, such as: start with 0.6V, increase progressively with the amplitude that △ V is amplification, to 9V.Testing procedure number depends on the value of △ V, and each voltage steps persistent period is that the scope of t, t is at (0.5s ~ 3s).Sample frequency scope is 10 ~ 1000HZ.Record anode and cathode voltage, record the magnitude of voltage of adjustable precision resistance on each testing procedure simultaneously.And stored by data processing module 106.
Average computation is adopted to ask its meansigma methods to the voltage of each increasing or decreasing step.Electric current is calculated by the resistance of adjustable precision resistance and magnitude of voltage, and according to this, with the voltage of anode for X-axis, is Y-axis, makes current-voltage curve figure, as shown in Figure 3 with electric current.
Before curve, attenuation portions mainly reflects the change of human body resistance and capacity effect, and electric current reduces along with the increase of voltage.There is flex point at 2.8V in curve, after current increase gradually with the increase of voltage, the superposition of three kinds of effects, electrochemical effect accounts for leading.
As can be seen from above-mentioned curve, human body resistance change, capacity effect, electrochemical effect are all such as included in 0.60 ~ 6V voltage range.Therefore using the voltage range that 0.60 ~ 6V tests below this combination of electrodes.
Exchange combination of electrodes is tested, and tests one by one all combinations.The voltage range tested is stored by data processing module 106, below obtained anticipation result being brought in the middle of the corresponding testing procedure surveying each step of compound electrode, as the voltage range of test.
Then enter step 203, in the voltage of this step test electrode both positive and negative polarity and adjustable precision resistive voltage and resistance value, concrete operation method is:
The DC voltage of positive direction 0.6V is applied on L1 anode electrode, continues a time t(0.5S ~ 5S), by the voltage of data processing module 106 recording electrode both positive and negative polarity and adjustable precision resistive voltage and resistance value;
Then apply the DC voltage of an equidirectional 0.6+ △ U immediately, wherein △ U can be the arbitrary value of 0 ~ 1V.And can select according to the rate request of test, the persistent period is similarly t.By the voltage of data processing module 106 recording electrode both positive and negative polarity and adjustable precision resistive voltage and resistance value; ......
Terminate until test voltage reaches 6V.Testing procedure number N=6-0.6/ △ U.Data processing module 106 records voltage of each step test electrode both positive and negative polarity and adjustable precision resistive voltage and resistance value.
Then, in the same way will the test of voltage access in the other direction, data processing module 106 records voltage of each step test electrode both positive and negative polarity and adjustable precision resistive voltage and resistance value.
Exchange another pair of electrodes (in the same way) to test, all electrodes are completed successively.Data processing module 106 records voltage of each step test electrode both positive and negative polarity and adjustable precision resistive voltage and resistance value.
Then enter step 204, in this step, carry out date processing by data processing module 106, make U ~ I curve chart of corresponding a pair test electrode, calculated curve areal array and flex point result:
Be data set, such as a L1 ~ L2 with the result of often pair of test electrode test, the data acquisition averaging method of the voltage of each continuation steps obtains meansigma methods.Make U=U
just-U
negative, wherein U
justfor being applied to the voltage of positive pole, U
negativefor the voltage of negative pole.Electric current is calculated by the resistance of adjustable precision resistance and magnitude of voltage.Be designated as I.Take U as abscissa, I is vertical coordinate, makes U ~ I curve chart, as shown in Figure 4.
Then for the electrode of correspondence, such as that corresponding with L1 ~ L2 is L2 ~ L1, makes and another curve relative to abscissa symmetry of the curve in Fig. 4.Article two, curve, is plotted in together as shown in Figure 5.
Area between calculated curve and X-axis, is designated as σ, as shown in Figure 4.
Calculate successively, the result of the area calculating gained is designated as combination { σ
1σ
2σ
n.
The foundation that acquired results is analyzed as next step diabetes characteristics of lesion.
Then enter step 205, in this step, carry out the analysis of diabetes characteristics of lesion by analysis module 107:
Carry out skin bio electricity Validity Test according to many cases experimenter (comprising normal person, impaired glucose tolerance patients, diabetics), obtain normal person, impaired glucose tolerance patients, the typical skin bioelectrical signals of diabetics as shown in Figure 6.Visible, the area that diabetics curve and X-axis comprise is greater than normal person, impaired glucose tolerance patients, and the area that impaired glucose tolerance patients and X-axis comprise takes second place, and normal person's area is minimum.
The impact that the bilateral of usual diabetes on extremity is subject to is symmetrical, and extremity distance is far away, and the impact be subject to is larger.Can investigate extremity separately from Point of View of Clinical, be the area under the curve σ of hands ~ hands
hands, the area σ of foot ~ foot
foot.The difference very Δ σ of the curve of the curve of hands and the area of X-axis and foot and the area of X-axis.
For through age, the corrected all objects of MBI value, by age (Age), Body Mass Index Score (BMI), σ
hands, σ
foot, Δ σ as the factor of influence in pathological data storehouse, the factor of influence of parameter different range builds different data bases, in analysis module 107, established many such data bases.
Data base's example based on the above-mentioned factor is as follows:
After experimenter's test, result (Age, BMI, σ of obtaining
hands, σ
foot, Δ σ parameter value) enter into data base and mate, just can show which kind of pathological condition experimenter belongs to.Such as, the test result of experimenter falls within the scope of the impaired glucose tolerance of data base, so just determines that this experimenter is in impaired glucose tolerance.For another example, the test result of experimenter falls into the diabetics scope of data base, so just determines that this experimenter belongs to diabetics.
The diabetes risk value of following judgement experimenter.
Obtain impaired glucose tolerance (IGT), insulin resistant (IR), diabetic complication (DC) and Δ sigma function relation respectively by oral glucose tolerance test, glycolated hemoglobin analysis, heart rate variability experiments of measuring (HRV) clinical trial supplementary means be:
F(IGT) ~ f(Δ σ): the function representing impaired glucose tolerance and trick skin signal of telecommunication difference in areas;
F(IR) ~ f(Δ σ): the function representing insulin resistant and trick skin signal of telecommunication difference in areas;
F(DC) ~ f(Δ σ): the function representing carbohydrate tolerance complication and trick skin signal of telecommunication difference in areas.
According to these empirical functional relationship, analysis module 107 just can calculate F(IGT according to the Δ σ value of the above-mentioned experimenter measured), F(IR) and F(DC) three values.
Diabetes risk size is obtained by following rule, and wherein K is constant, the constant that different phase value is different.Diabetes risk (rise) scope:
Normal person: IR≤50, IGT≤40, rise≤25, and F(rise)=K × f(IGT) × f(IR);
Impaired glucose tolerance but be not glycosuria patient: IR≤50, IGT>40,25<rise≤50, and F(rise)=K × f(IGT) × f(IR);
Patient of diabetes but without complications: IR>50, DC<60,50<rise≤75, and F(rise)=K × f(IR) × f(DC);
Patient of diabetes and with complications: IR>50, DC>60,75<rise≤100, and F(rise)=K × f(IR) × f(DC).
Accordingly, diabetes risk value can be calculated, and export final result.
More than describe non-invasive detection system and the method thereof of the early stage subclinical asymptomatic diabetes of the present invention in detail.More than describing provides in exemplary fashion, and not to be intended to limit the scope of protection of present invention.It will be appreciated by those skilled in the art that the embodiment of the modification of the embodiment of described the technology of the present invention and the various combination according to the technology of the present invention.
Claims (2)
1. be used to an analytical method for the human body skin bioelectrical signals of early stage subclinical asymptomatic diabetes, comprise:
The resistance of anticipation experimenter human body and capacity effect equivalent resistance (201), realize equivalent resistance by regulating the adjustable precision resistance be connected in the loop of described human body and measure;
Carry out the test of human body skin bioelectrical signals, comprise anticipation actuation voltage range and carry out testing (202) in this scope;
The voltage of test electrode both positive and negative polarity and adjustable precision resistive voltage and resistance value (203);
Carry out date processing (204), form U ~ I curve chart of electrode, calculate the areal array between U ~ I curve and X-axis; And
The applied analysis of human body skin bioelectrical signals, comprising:
Measure one group of skin bioelectrical signals between human body different parts, with the cartographic represenation of area of current-voltage;
Obtain the difference in areas Δ σ of the skin bioelectrical signals of described human body different parts;
By the area under the curve σ of described difference in areas Δ σ together with age, Body Mass Index Score, hands ~ hands
hands, foot ~ foot area under the curve σ
footas variable quantity building database.
2. the method for claim 1, is characterized in that:
The method of described anticipation experimenter equivalent resistance is divided into two steps to carry out, and first carries out coarse adjustment on a large scale, then carries out limiting accurately debugging among a small circle;
The scope of first step coarse adjustment is on a large scale carried out between adjustable precision resistance gamut, and resistance is reduced to 0 Ω gradually by 1M Ω, by the voltage U of adjustable precision resistance
0the resistance being approximately adjustable precision resistance corresponding to the half of supply voltage V is designated as the result R of coarse adjustment
0, R
0stored by data processor and be called in ensuing accurate debugging, the meticulous adjustment method of second step is the result R in first step coarse adjustment
0basis sets (R
0+ R
0/ 2) ~ (R
0-R
0/ 2) carry out in scope;
For the scope of described adjustable precision resistance of above-mentioned steps debugging at 0 ~ 1M Ω, precision is 100 Ω.
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| CN104739408A (en) * | 2015-03-27 | 2015-07-01 | 深圳市前海安测信息技术有限公司 | Diabetes early-stage electrophysiology detecting method and system |
| CN105476632A (en) * | 2015-11-10 | 2016-04-13 | 北京章鱼智数科技有限公司 | Human body electrical impedance health risk assessment system and human body electrical impedance health risk assessment method |
| CN105361882A (en) * | 2015-12-08 | 2016-03-02 | 合肥芯福传感器技术有限公司 | Biological coherence degree detecting device and method |
| CN105997071A (en) * | 2016-05-10 | 2016-10-12 | 咸阳康荣信数字超声系统有限公司 | A sweat concentration-based human body conductance test analysis instrument |
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| CN101247759A (en) * | 2005-06-22 | 2008-08-20 | 安尼克·妮科尔·莉迪·图尔内菲耶 | Electrophysiological analysis system and method |
| CN101657154A (en) * | 2007-02-23 | 2010-02-24 | 因佩多医药公司 | Electrophysiological analysis system |
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