CN103191400A - Traditional Chinese medicine compound drug for preventing and treating transmissible gastroenteritis of swine - Google Patents
Traditional Chinese medicine compound drug for preventing and treating transmissible gastroenteritis of swine Download PDFInfo
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- CN103191400A CN103191400A CN2013101446922A CN201310144692A CN103191400A CN 103191400 A CN103191400 A CN 103191400A CN 2013101446922 A CN2013101446922 A CN 2013101446922A CN 201310144692 A CN201310144692 A CN 201310144692A CN 103191400 A CN103191400 A CN 103191400A
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Abstract
The invention discloses a traditional Chinese medicine compound drug for preventing and treating transmissible gastroenteritis of swine. The compound drug disclosed by the invention comprises the components of 150+/-10 parts of wrinkled giant hyssop, 100+/-10 parts of codonopsis pilosula, 100+/-10 parts of white atractylodes rhizome, 50+/-5 parts of radix aconiti carmichaeli (processed), 50+/-5 parts of pinellia ternate, 50+/-5 parts of tuckahoe, 100+/-10 parts of platycodon grandiflorum, 100+/-10 parts of baked ginger, 80+/-10 parts of fructus evodiae, and100+/-5 parts of honey-fried licorice root. The test shows that the traditional Chinese medicine compound drug has the functions of resolving damp with aromatics, detoxifying and evacuating turbid, rescuing from collapse by restoring yang, eliminating cold to stop pain, calming the adverse-rising energy to stop vomiting, replenishing qi to invigorate the spleen, and strengthening body resistance and eliminating evil, and can effectively prevent and treat the transmissible gastroenteritis of swine.
Description
Technical field
The present invention relates to a kind of formed by Chinese medicine, the compound medicine that can prevent and treat transmissible gastroenteritis of swine.
Background technology
Transmissible gastroenteritis of swine (transmissible gastroenteritis of swine, TGE) claim the gastroenteritis of young pig again, be a kind of height contagiousness, with vomiting, serious diarrhoea, dehydration, cause that the piglet high mortality is the viral infectious of feature in two ages in week.Infect the back with interior piglet and can occur vomiting in 12-24 hour general 2 age in week, occurs serious water sample or pasty state diarrhoea then, and it is yellow that feces is, often accompany indigested ziega, stench, body weight descends rapidly, piglet obviously dewaters, the death in 2-7 days of falling ill, and mortality rate reaches 100%; The 2-3 piglet in age in week, mortality rate is at 0-10%.The ablactation pig infects back morbidity in 2-4 days, and the performance watery diarrhea is spurting, feces gray or brown, and indivedual pig vomitings, suffering from diarrhoea after 5-8 days stops, few dead, but weight loss often shows dysplasia, becomes cad pig.Some sow contacts repeated infection closely with ill piglet, and symptom is heavier, fervescence, and lactogenic stops, vomiting, inappetence and diarrhoea, some nursing sow does not show clinical symptom yet.
The transmissible gastroenteritis of swine symptom is to cause diarrhea of pigs, vomiting, dehydration, symptom such as become thin.Its main pathology variation characteristic is intestinal mucosa hyperemia, edema, and intestinal mucosa comes off etc.Diarrhoea sees piglet usually, also sees sow, and it has been that piglet growth is obstructed and the high major reason of mortality rate.Bring heavy losses in these years for China's pig industry.The zone of being everlasting is popular, the heterogeneous susceptible of patient, and infectiousness is strong, and the mortality rate height often causes large quantities of piglet death.Very the person causes being annihilated, and is very harmful to pig industry, is badly in need of seeking suitable antiviral antibacterials and comes the specific aim treatment, becomes a noticeable worldwide problem.At present the transmissible gastroenteritis of swine doctor trained in Western medicine is not still had desirable Therapeutic Method, do not have specific drug yet.The method of taking just is mitigation symptoms, reduces death, shortens the course of disease, reduces loss.Be generation and the popular normal employing vaccination therapy of preventing this disease, but vaccine effect is not good enough, controlling above-mentioned disease fully by vaccine has great difficulty.Use hyper-immune serum, yolk antibody treatment primary disease, although curative effect is better, cost is too high.Abuse chemical medicine, antibiotic and monomer medicine without restraint, both produced the super many drug-induced disease such as quick of polynary drug resistance and receptor, cause animal products to pollute again, jeopardize human food's safe and sanitary.Chinese medicine derives from animal, plant and mineral, contains multiple biological effective components, and wherein most of Chinese medicines are to be raw material with the natural plants, aboundresources, obtain easily, respond well, cheap, toxic and side effects is small, almost noresidue, no Drug resistance, free from environmental pollution.Therefore, select for use Chinese medicine preparation to substitute chemical medicine, antibiotic seems particularly important.
Summary of the invention
The invention provides and a kind ofly constitute with Chinese medicine composition, can be used for preventing and treating the compound medicine of transmissible gastroenteritis of swine.
Compound medicine of the present invention consists of: Herba Pogostemonis 150 ± 10 weight portions, Radix Codonopsis 100 ± 10 weight portions, the Rhizoma Atractylodis Macrocephalae 100 ± 10 weight portions, Radix Aconiti Lateralis Preparata (system) 50 ± 5 weight portions, the Rhizoma Pinelliae 50 ± 5 weight portions, Poria 50 ± 5 weight portions, Radix Platycodonis 100 ± 10 weight portions, Rhizoma Zingiberis Preparatum 100 ± 10 weight portions, Fructus Evodiae 80 ± 10 weight portions, Radix Glycyrrhizae Preparata 100 ± 5 weight portions.Medicine of the present invention can be pulverized above 10 herbal medicines when concrete the use, sieves, behind the mixing directly for the poultry feeding, also can be again with its active ingredient of water extraction to the poultry feeding.
Chinese veterinarian thinks that transmissible gastroenteritis of swine belongs to Chinese veterinarian's cholera category, and Chinese veterinarian's cholera is hurried with onset, suddenly outbreak, vomiting and dirarrhea, stomachache or bitterly disease not.Due to illness become and arise from no time, spend freely formal confused, so the name cholera.The scope of Chinese veterinarian's cholera is wider, comprises the diseases such as cholera, pasracholera, acute gastroenteritis and bacterial food poisoning of doctor trained in Western medicine.
Primary disease is multiple is born in autumn and winter season, and suffering from poultry has situations such as the greedy cool and rotten food of turning sour of feed again mostly, so think mainly due to experiencing due to the cold-damp foul gas and unhygienic diet.Because the foul tired spleen of cold-damp, taste are injured, lifting mistake department, and abnormal ascent-descent between clear YANG and turbid YIN, mechanism of qi is disorderly contrary, does so vomit and diarrhoea to hand over.Said as " danxi's experiential therapy cholera " piece of writing: " interior long-pending to some extent, sense to some extent causes into vomiting and diarrhoea outward ".Because of its vomiting and diarrhoea, so the body fluid excessive loss at short notice, wan and sallow looking can occur, and orbit sink, and muscle arteries and veins contraction is anxious, critical syndrome such as extreme cold of the limbs.
Chinese veterinarian thinks that the generation of primary disease mainly is that (1) experiences seasonal pathogen: in the season of autumn and winter, the damp transpiration is if it is inappropriate to take good care of oneself, experience the foul pestilential pathogen of cold-damp, or sleep in the open because of greedy cold, cold-damp is invaded, the exopathogen oxious gas is strongly fragrantly held back middle Jiao, all can make taste injured, dysfunction of the spleen in transportation and transformation, disorder of QI movement, lifting mistake department, abnormal ascent-descent between clear YANG and turbid YIN, disorderly in the intestines and stomach, vomiting and dirarrhea forms.(2) feed unclean: it is unclean to feed, and mistake is advanced the rotten rotten food of turning sour, or cold and cool feedstuff, can impairing the spleen and stomach, pure and impure mixing mutually forms.
In sum, primary disease mainly is to experience the foul gas of cold-damp, cold-damp disturbing the spleen, deficiency of spleen-QI and stomach-QI, hypoactivity of YANG in middle-JIAO, yang deficiency is then given birth to endogenous cold, stagnates and cause mechanism of qi, and lifting is disorderly contrary, and the spleen master transports fortuneization and sending up the lucid YANG, stomach receiving food and drink and the turbid descending the moon, void has coldly in the present, and lifting dereliction of duty is so suffer from abdominal pain loss of appetite for vomiting and diarrhea.Sick deeply few cloudy to the cold-evil, decline of YANG QI is little in the kidney, and the gas of negative and positive is mutually along connecing, thus outward then extremity faint contraryly, dislike cold Curled and crouch Mental fatigue somnolence.In then vomit not the desire drink, the stomachache diarrhea.Control and should removing dampness ward off dirty, warming spleen and stomach for dispelling cold, dysentery is controlled in recuperating depleted YANG and rescuing the patient from collapse, spleen invigorating.
Medicine of the present invention is to use
Herba PogostemonisHot warm cold expelling, removing dampness by means of aromatics, regulate the flow of vital energy and in, stomach function regulating is pleased spleen, wards off the evil preventing or arresting vomiting, the double the exterior and the interior of controlling;
Radix Aconiti Lateralis PreparataPure sun is kidney-yang first key medicine of the congenital gate of vitality of tonification, and current 12 warps are monarch with warming YANG by trembling with fear with then fastly reaching inside and outside.
Rhizoma Zingiberis PreparatumThe sun of warm the middle warmer and go out interior cold helps Radix Aconiti Lateralis Preparata to stretch to send out a yang-energy, and can stopping nausea and vomiting by lowering the adverse flow of QI, makes gastric qi and suitable;
Radix CodonopsisThe QI invigorating invigorating YANG, the spleen invigorating the lucid yang sending up cooperates Rhizoma Zingiberis, coordinates the QI of the spleen and stomach lifting; The hot warm cold expelling of Fructus Evodiae, warm liver stomach warming, kind lowering the adverse flow of QI is ministerial drug altogether.
The Rhizoma PinelliaeThe dampness sending down the abnormal ascending QI, the stomach function regulating preventing or arresting vomiting;
The Rhizoma Atractylodis MacrocephalaeThe spleen strengthening and damp drying helps the Radix Codonopsis QI invigorating;
PoriaSpleen invigorating fortune is wet,
Radix PlatycodonisThe sharp diaphragm of lung qi dispersing is adjuvant drug altogether.
Radix GlycyrrhizaeQI invigorating and middle emergency, and can separate the poison of Radix Aconiti Lateralis Preparata, can relax Radix Aconiti Lateralis Preparata, the hot strong property of Rhizoma Zingiberis again for making and all medicines.Healthy energy is unobstructed, and is then evil contrary from removing.
The present invention has that removing dampness by means of aromatics, detoxifcation row are turbid, recuperating depleted YANG and rescuing the patient from collapse, dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, replenishing QI to invigorate the spleen, strengthening vital QI to eliminate pathogenic factors function.Prescription is fully with reference to Chinese veterinarian's eight guiding principles for diagnosis, defensive-qi-nutrient-blood, determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs theory, giving consideration to both the exterior and interior, QI and blood is ruled together, special with YAOJING, compatibility is careful and precise, has embodied " prevention of diseae " again, the prevention thought of " preventing exacerbation after being taken ill ", embodied medication as using military forces, the road of using military forces is essence, and the road of medication is pure prescription characteristic.
Modern veterinary's pharmacological research and clinical prolonged application facts have proved that Chinese medicine has whole curative effect height, be difficult for producing drug resistance, residual low, advantages such as toxic and side effects is little, its growth and breeding to many virus causing diseases has significant inhibitory effect, even reaches the pharmacological effect of killing cause of disease.The present invention is according to the cause of disease of pig virus diarrhoea, pathogenesis, clinical pathology and drug mechanism, carry out Chinese medicine compound control transmissible gastroenteritis of swine, develop evident in efficacy, reliable in quality, it is convenient to use, cheap compound Chinese medicinal preparation, and in Swine Production, apply, very important economy and social meaning had for the sound development that promotes pig industry.
The specific embodiment
Below in conjunction with test the present invention is explained orally.
Be to use Herba Pogostemonis 15kg in the specific embodiment of the present invention, Radix Codonopsis 10kg, Rhizoma Atractylodis Macrocephalae 10kg, Radix Aconiti Lateralis Preparata (system) 5kg, Rhizoma Pinelliae 5kg, Poria 5kg, Radix Platycodonis 10kg, Rhizoma Zingiberis Preparatum 10kg, Fructus Evodiae 8 kg, Radix Glycyrrhizae Preparata 10kg.Accurately take by weighing each medicine in last several ratios, drying is pulverized, and crosses 60 mesh sieves, mixing.Packing is standby.
1) therapeutic test
The present invention adopts the random double blind test method to carry out the transmissible gastroenteritis of swine therapeutic test of various dose treatment natural occurrence, and selects the positive medicine matched group of florfenicol for use.Observe the present invention to the transmissible gastroenteritis of swine therapeutical effect, to inquire into its Application feasibility in Production of Livestock and Poultry.
Therapeutic test to the transmissible gastroenteritis of swine of natural occurrence: the sick pig that natural occurrence is made a definite diagnosis transmissible gastroenteritis through clinical diagnosis and laboratory diagnosis is divided into 5 groups, 30 every group at random.The 1-3 group is for adopting medication therapy groups of the present invention (establishing three groups of basic, normal, high dosage respectively); The 4th group is florfenicol powder positive drug matched group; The 5th group of positive matched group (infecting not administration).Isolated rearing respectively, situations such as the symptom of the sick pig of itemized record, healing, death.
Medication, administration time: 1 group of medicine: every pig medicine 15g(piglets of the present invention of feeding every day reduces by half), connect and fed 5 days; 2 groups of medicines: every pig medicine 30g(piglets of the present invention of feeding every day reduces by half), connect and fed 5 days; 3 groups of medicines: every pig medicine 45g(piglets of the present invention of feeding every day reduces by half), connect and fed 5 days.The positive drug matched group: every pig (10%) florfenicol powder 20mg/ kg body weight (in florfenicol) of feeding every day connects and fed 5 days; Positive controls: not administration.
Experimental result: behind the treatment group medicine feed 24h, the spirit of the sick pig of medicine group is better than positive controls, adds up death toll behind 36 h, and the medicine group is obviously lacked than the positive controls death toll by sick pig; Observe behind 48 h, improvement in various degree appears in each group of medicine, and positive controls still has dead generation the successively.Behind 3 d, spirit, the appetite of the sick pig of medicine group take a favorable turn (increase from sucking amount, feeding capacity and find out), and feces is normal
The test statistics result shows that medicine high-dose therapy group cure rate of the present invention is 65.0%, and mortality rate is 20.1%, and total effective rate is 79.9% respectively; Middle dosage treatment group cure rate is 64.5%, and mortality rate is 20.5%, and total effective rate is 79.5% respectively; Low dose treatment group cure rate is 40.0%, and mortality rate is 60.2%, and total effective rate is 39.8% respectively; Florfenicol treatment group cure rate is 55.0%, and mortality rate is 30.2%, and total effective rate is 69.8%; The age in days of statistics was 90.0% on 10th with interior positive controls (not administration) mortality rate separately, and the age in days of statistics only was 45.0% on 10th with interior height, middle dosage treatment group piglets mortality rate separately, and treatment is organized the disease pig than the sick pig of matched group, show as sx, the course of disease shortens, experimental results show that the high, medium and low dosage of the present invention has therapeutical effect to the transmissible gastroenteritis of swine disease, the energy relief of symptoms, reduce mortality rate, and high, middle dosage is reducing mortality rate, and aspects such as raising cure rate all are better than the effect of florfenicol.High, middle dosage the present invention can reach the effect of curing the disease, improve survival rate, and both zero differences on 0.05 level, so dosage, so not only economic curative effect but also remarkable in can adopting during clinical use.
2) prophylactic tria
On the pig farm that epidemic situation takes place, 100 health pig that do not fall ill is divided into 2 groups at random, 50 every group, the 1st group is the chemoprophylaxis group; The 2nd group is matched group; The 1st group every pig feedstuff every day adds hello medicine 15g(piglets of the present invention and reduces by half), connect and fed 7 days; The 2nd group is not added; Two groups of other measures of pig are all by the pig farm immune programme for children of normally sterilizing.
The result shows: the sickness rate of chemoprophylaxis group transmissible gastroenteritis of swine is 5.0%, and the matched group sickness rate is 75.0%, and spirit, the appetite of medicine group morbidity pig all is better than matched group, and illness symptom is also light than matched group.The prevention group give after the morbidity with treatment after, cure rate is 70.0%; And matched group is 40.0%.
From result of the test, the present invention has removing dampness by means of aromatics, the functions such as row is turbid, recuperating depleted YANG and rescuing the patient from collapse, dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, replenishing QI to invigorate the spleen, strengthening vital QI to eliminate pathogenic factors of detoxifying.Do not find that in the clinical trial process this medicine has untoward reaction.High, medium and low dosage has better therapeutic effect to the transmissible gastroenteritis of swine disease.The therapeutic effect of low dose group is lower than height, middle dosage group, middle and high dosage group there are no significant aspect mortality rate, cure rate and total effective rate difference.Should be according to weight and the treatment cost of the state of an illness, the suggestion clinical practice is with middle dosage (pig 30～50g; Every day, be used in conjunction 3～5 days; Or mixed feeding, every 1kg feedstuff 20～40g) is used in conjunction 3～5 days for well.
For clear and definite toxic and side effects of the present invention, in the hope of its safety is made accurately, objective appraisal, for the clinical trial medication provides scientific basis, guarantee clinical drug safety, carried out toxicity test of the present invention.
By mice is carried out LD of the present invention
50Show that with mtd test after design dosage oral administration, it is normal respectively to organize mice behavior sign in 7 days, poisoning symptom and death all do not occur.So can't measure LD
50, and have to be maximum dose level with maximum dosage-feeding 60g/kg.After slaughtering in the 8th day, each organizes the mice internal organs does not all have pathological changes, and pathological characters is not found in the liver,kidney,spleen histological examination yet.Hemogram and serum GPT are active to detect result and normal mouse there was no significant difference.
Use Chinese herb compound the present invention to produce toxicity and the order of severity in order to grasp because of continuous, and the development after the drug withdrawal and recovery situation, reference provided for drafting data for clinical drug use dosage.Carried out subacute toxicity test of the present invention mice, in experimental period, except high dose group is ingested because drug dose causes the palatability difference to influence greatly, all the other respectively organize the mice diet, behavior, and feces is all normal, physically well develop, do not have any poisoning symptom, weightening finish and nutrition except high dose group and matched group significant difference, all the other there are no significant differences.The hemogram of each group and serum GPT are all in normal range.Histological examination, liver,kidney,spleen etc. all do not have obvious poisoning pathological changes.By the 3-10 of the clinical application amount 30d that doubly feeds, do not see toxic and side effects yet, the clinical medicine dose that said preparation is described is very safe.
Medicine of the present invention is according to the listing terms of packing, in temperature: 40 ℃ ± 2 ℃, relative humidity: accelerate experiment 3 months under 75% ± 5% condition, quality does not have significant change.In temperature: 25 ℃ ± 2 ℃ relative humiditys: long term test is 24 months under 60% ± 10% condition, and quality does not have significant change.Above-mentioned result of the test shows that medicine of the present invention storage quality under rated condition is stable.
Claims (1)
1. treat or prevent the traditional Chinese compound medicine of transmissible gastroenteritis of swine, it is characterized in that compound medicine consists of:
Herba Pogostemonis 150 ± 10 weight portions, Radix Codonopsis 100 ± 10 weight portions, the Rhizoma Atractylodis Macrocephalae 100 ± 10 weight portions,
Radix Aconiti Lateralis Preparata (system) 50 ± 5 weight portions, the Rhizoma Pinelliae 50 ± 5 weight portions, Poria 50 ± 5 weight portions,
Radix Platycodonis 100 ± 10 weight portions, Rhizoma Zingiberis Preparatum 100 ± 10 weight portions, Fructus Evodiae 80 ± 10 weight portions,
Radix Glycyrrhizae Preparata 100 ± 5 weight portions.
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Cited By (2)
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| CN103394053A (en) * | 2013-07-18 | 2013-11-20 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours as well as preparation and applications thereof |
| CN106729589A (en) * | 2017-03-14 | 2017-05-31 | 韦煜辉 | Treat the Chinese medicine preparation and preparation method of transmissible gastroenteritis of swine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394053A (en) * | 2013-07-18 | 2013-11-20 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition capable of preventing and treating piglet yellow and white scours as well as preparation and applications thereof |
| CN106729589A (en) * | 2017-03-14 | 2017-05-31 | 韦煜辉 | Treat the Chinese medicine preparation and preparation method of transmissible gastroenteritis of swine |
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| CN103191400B (en) | 2014-06-11 |
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