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CN103125747B - Feed additive and application thereof - Google Patents

Feed additive and application thereof Download PDF

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Publication number
CN103125747B
CN103125747B CN201310095181.6A CN201310095181A CN103125747B CN 103125747 B CN103125747 B CN 103125747B CN 201310095181 A CN201310095181 A CN 201310095181A CN 103125747 B CN103125747 B CN 103125747B
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China
Prior art keywords
feed
ncg
sow
feed additive
feed addictive
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Expired - Fee Related
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CN201310095181.6A
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Chinese (zh)
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CN103125747A (en
Inventor
冯涛
刘彦
白佳桦
许晓玲
郭勇
黄正
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Beijing Eldorado Feedstuff Science Exploiture Co., Ltd.
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Beijing Academy of Agriculture and Forestry Sciences
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Priority to CN201310095181.6A priority Critical patent/CN103125747B/en
Publication of CN103125747A publication Critical patent/CN103125747A/en
Application granted granted Critical
Publication of CN103125747B publication Critical patent/CN103125747B/en
Expired - Fee Related legal-status Critical Current
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Abstract

The invention provides a feed additive and an application thereof. The feed additive provided by the invention comprises N-carbamylgulatamate (NCG) and vitamin C (VC), wherein the weight ratio of the NCG to the VC is (1-2): (1-2). According to the feed additive, NCG and VC are combined, and production performance of livestock, especially a sow, can be obviously improved, so that the NCG and the VC have an synergistic effect, and the feed additive can be widely popularized and applied in the field of livestock breeding and has a good market effect and a good social effect.

Description

A kind of feed addictive and application thereof
Technical field
Livestock culturing field of the present invention, is specifically related to a kind of feed addictive, also relates to this feed addictive and is improving the application in sow production performance.
Background technology
Feed addictive refers at Feed Manufacturing processing, a small amount of or micro substance that adds in use procedure, in feed consumption seldom but effect significantly.Feed addictive comprises nutritive additive, medicine class additive and some promotions digest or the additive of metabolism, it, to strengthening basal feed nutritive value, improves breeding performonce fo animals, ensures animal health, save feed cost, improving the aspects such as livestock products quality has obvious effect.
N-carbamylglutamic acid (N-Carbamylglutamate, NCG), Chinese is N-carbamylglutamic acid.In the past, NCG mainly used the mankind, significantly can increase muscle yield on the one hand as nutrition fortifier, urged in the product of muscle growth for body building; Some orphan disease of the mankind is used for the treatment of on the other hand: N-acetylglutamat as congenital in neonate (NAG) synzyme lacks the hyperammonemia and the rare genetic disease-maple syrup urine disease of neonate (Kalkan etc., 2009) that cause as medicine.Recent research shows, NCG, by promoting arginic endogenous synthesis, improves multiparous animal (pig and mouse) nest litter size and birth weight, strengthens the reproductive capacity of buck, promotes young animal g and D.
NCG adds in sow diets can improve nest litter size and birth weight really, from different result of study, about the suitableeest addition of NCG in sow diets should be 0.5kg/ ton, but only from addition, cannot improve its effect further.NCG as a kind of conventional feed addictive, itself and vitamin C with the use of effect there is no bibliographical information at present.
Summary of the invention
The object of the present invention is to provide a kind of feed addictive, in order to improve the production performance of domestic animal.
For achieving the above object, feed addictive provided by the invention, it includes NCG and the vitamin C of effective amount, and preferred described NCG and ascorbic weight ratio are 1 ~ 2:1 ~ 2, are more preferably 1:1.
The invention provides the feed containing above-mentioned feed addictive further, its content in feed is preferably 0.05 ~ 0.15%(w/w), be preferably 0.1%.
Feed of the present invention and feed addictive may be used for the production capacity improving domestic animal, include but not limited to pig, especially say sow.
Feed addictive of the present invention can directly make an addition in the daily ration of domestic animal, also can add with other feed addictives simultaneously, but should be noted that the combination matching of various composition when adding.
Time period between feed addictive of the present invention should wean to cub before manufacture adds, and can improve income and input ratio to greatest extent like this.Such as, sow should add feed addictive of the present invention between 1 month to weaning period before manufacture.
N-carbamylglutamic acid in feed addictive of the present invention is N-acetylglutamat (i.e. NAG) analog, and can play a role as NAG in animal body and participate in body urea cycle, long half time, metabolic stability, has biological function widely.Research shows, NCG can as metabolic activation agent participate in dihydropyrrol-5-carboxylic acid synzyme (P5CS) and carbamyl phosphate synthetase I(CPS-I) activation, promote glutamine or proline synthesis citrulling, and then promote the synthesis (Wu etc. of arginine (Arg), 2004), also activator in arginine is therefore referred to as.As NAG analog, NCG makes body arginine maintain higher physiological level, can be converted into the material of important biomolecule activity after a series of metabolic process, mainly nitric oxide (NO) and polyamines (comprising putrescine, spermidine and spermine).These materials play an important role in regulation and control body Nutrition and Metabolism and immune response, especially like this on multifetation animal.
Vitamin C in the present invention is as water-soluble free radical scavenger, and the reaction participated in is more than fat-soluble free radical scavenger vitamin E, so the mechanism of vitamin C scavenging free radicals is also enriched than vitamin E.Vitamin C, except directly playing except the function of scavenging free radicals, can also assist vitamin E and glutathione scavenging free radicals.In swine rearing standard (NY/T65-2004) to content ascorbic in sow feed without explicitly calling for.In recent years since, vitamin C is improving the reproductive capacity of pig, prevents and treats the aspects such as infectious disease, poisoning and metabolic disease and finds broad application, and achieve significant effect (good fortune establishes power, 2012).
Feed addictive of the present invention makes an addition in sow feed and can improve number born of sow, number born alive, weigth at birth, nascent individual counterpoise, 21 ages in days young number alive, 21 age in days litter weights, 21 ages in days individual counterpoise, 21 age in days survival rates, numbers of weaned, especially show and significantly improve on weigth at birth, nascent individual counterpoise, 21 age in days litter weights, the individual counterpoise of 21 ages in days, and then improve the production efficiency of sow, increase the economic benefit of feeding mother pig.And the present invention's research shows, the production performance of domestic animal cannot be improved by means of only the amount improving NCG, and only add vitamin C and also do not show the significant difference in production performance, but after both are combined, its production performance significantly improves, and shows that NCG and vitamin C create synergy.
Detailed description of the invention
Following examples are used for further illustrating the present invention, but should not be construed as limitation of the present invention.Under the prerequisite not deviating from the present invention's spirit and essence, modification made for the present invention or replacement, all belong to category of the present invention.
Embodiment 1
1. material
1.1 additive N-carbamylglutamic acids (purity >=97%), vitamin C (purity >=99%)
1.2 animal genealogy of law large white sows (pig farm, large-scale kind of Beijing)
2. method and result
2.1 experimental design
In sow feeding experiment, choose age, the subuniform genealogy of law large white sow of tire 200, be divided into 10 groups at random, often organize 20.Often organize the one process in carry out table 1 at random, the raising stage often organized and additive addition are in table 1.
Table 1 experimental design
After experiment starts, observe the situation of searching for food often organizing sow, the data such as number born of sow, number born alive, weigth at birth, 21 ages in days young number alive, 21 age in days litter weights, wean young number alive often organized in record, calculates the index such as nascent individual counterpoise, 21 ages in days individuality counterpoise, 21 age in days survival rates, numbers of weaned.
2.2 sow feeding experiments
Sow feeding experiment the results are shown in Table 2.
From table 2, it is bred production performance and is all better than control group to add NCG, vitamin C or NCG and ascorbic composition in sow different phase feed, wherein obvious with G group effect, namely when antenatal January-weaning stage adds 0.5kg/ ton NCG and 0.5kg/ ton vitamin C composition, the breeding production performance of sow is better than other groups, can obtain maximum litter weights and individual counterpoise and number of weaned when being mainly manifested in 21 age in days.
Table 2-1 sow feeding experiment result
Experimental group A B C D E
Litter size (head) 11.18±2.30 11.15±1.31 11.00±1.63 10.82±1.54 10.73±1.75
Number born alive (head) 10.47±1.77 10.75±1.37 10.69±1.45 10.39±1.96 10.31±1.75
Weigth at birth (㎏) 15.44±3.31ab 16.00±2.85ab 16.08±4.00ab 14.13±3.20b 13.92±2.96b
Nascent individual counterpoise (㎏) 1.47±0.31ab 1.49±0.22ab 1.50±0.28ab 1.36±0.25b 1.35±0.27b
21 ages in days young number (head) alive 9.85±1.67 10.13±2.68 9.94±1.69 9.65±1.85 9.56±2.13
21 age in days litter weight (㎏) 52.99±11.08ab 56.53±13.07a 55.14±8.30a 51.72±10.26ab 50.29±9.53ab
21 ages in days individual counterpoise (㎏) 5.38±0.86ab 5.29±0.70ab 5.60±0.59ab 5.36±0.63ab 5.26±0.77ab
21 age in days survival rates (%) 94.07 94.19 92.98 92.86 92.69
Number of weaned (%) 92.94 93.69 91.23 91.56 91.87
Table 2-2 sow feeding experiment result
Note: show significant difference (p<0.05) with the different lowercase alphabet of a line, different capitalization represents that difference extremely significantly (p>0.05).

Claims (6)

1. a feed addictive, it is made up of NCG and vitamin C, and described NCG and ascorbic weight ratio are 1:1.
2. the feed containing feed addictive described in claim 1.
3. feed according to claim 2, is characterized in that, the content of described feed addictive is 0.05 ~ 0.15% (w/w).
4. feed according to claim 3, is characterized in that, the content of described feed addictive is 0.1% (w/w).
5. feed addictive according to claim 1 or the feed described in any one of claim 2 ~ 4 are improving the application on sow production performance.
6. application according to claim 5, is characterized in that, produces between the previous moon to weaning period use described feed addictive or feed sow.
CN201310095181.6A 2013-03-22 2013-03-22 Feed additive and application thereof Expired - Fee Related CN103125747B (en)

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CN103125747B true CN103125747B (en) 2015-04-29

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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103202392B (en) * 2013-04-23 2014-11-12 北京市农林科学院 Application of NCG (N-CarbamylGlutamate) and VC (Vitamin C) in preparing heat stress-resisting feed additives or feeds
CN104431596B (en) * 2014-12-18 2017-10-20 宁夏大学 Improve the daily ration of drylot feeding sheep and goat carcass quality
CN110368132B (en) * 2019-06-24 2020-09-15 华中农业大学 Treatment method for improving synchronous estrus-timing insemination effect of dairy cows in summer
CN114052130A (en) * 2021-12-02 2022-02-18 吉林大学 Composition for promoting growth of yaks and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101953430A (en) * 2010-07-15 2011-01-26 北京龙科方舟生物工程技术中心 Feed, preparation method and use thereof in improvement in reproductive performance of sows
CN102106472A (en) * 2010-12-07 2011-06-29 北京龙科方舟生物工程技术中心 Complex additive for boars and preparation method and using method thereof
CN102423006A (en) * 2011-11-15 2012-04-25 辽宁禾丰牧业股份有限公司 Compound feed for lactating sows
CN102630638A (en) * 2012-05-10 2012-08-15 广东温氏食品集团有限公司 Method for improving the reproductive performance of sows

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101953430A (en) * 2010-07-15 2011-01-26 北京龙科方舟生物工程技术中心 Feed, preparation method and use thereof in improvement in reproductive performance of sows
CN102106472A (en) * 2010-12-07 2011-06-29 北京龙科方舟生物工程技术中心 Complex additive for boars and preparation method and using method thereof
CN102423006A (en) * 2011-11-15 2012-04-25 辽宁禾丰牧业股份有限公司 Compound feed for lactating sows
CN102630638A (en) * 2012-05-10 2012-08-15 广东温氏食品集团有限公司 Method for improving the reproductive performance of sows

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Effective date of registration: 20160214

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Patentee after: Beijing Eldorado Feedstuff Science Exploiture Co., Ltd.

Address before: 100097 Beijing, Haidian District Shuguang Garden Road, No. 9

Patentee before: Beijing Academy of Agriculture and Forestry Sciences

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Granted publication date: 20150429

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