CN103071094B - Chinese medicinal composition for preventing and treating swine enzootic pneumonia as well as preparation and application thereof - Google Patents
Chinese medicinal composition for preventing and treating swine enzootic pneumonia as well as preparation and application thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for preventing and treating swine enzootic pneumonia, which comprises the following components in part by weight: 25 to 40 parts of tatarian aster root, 15 to 28 parts of sessile stemona root, 10 to 20 parts of bitter apricot seed, 8 to 15 parts of white mulberry root-bark, 10 to 20 parts of loquat leaf and 8 to 20 parts of houttuynia cordata. The Chinese medicinal composition disclosed by the invention has high cure rate on swine enzootic pneumonia; by observing a curative effect of an artificially pathogenetic swine enzootic pneumonia model, high and middle dose groups of tested medicaments have obvious effects on the curative effect on swine enzootic pneumonia and weight increase of swines; and the Chinese medicinal composition is totally suitable for preventing and treating swine enzootic pneumonia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly, relate to a kind of Chinese medicine composition and preparation and application that prevents and treats swine enzootic pneumonia.
Background technology
Swine enzootic pneumonia (mycoplasmal pneumonia of swine, epidemic swine pneumonia) is a kind of direct contact, chronic respiratory infectious disease.The cause of disease of primary disease is mycoplasma hyopneumoniae (Mycoplasma hyopneumoniae, Mhp), and main clinical manifestation is cough, asthma.Pathological change position is mainly positioned at thoracic cavity, and lungs are major organs of pathological changes, and acute case be take pulmonary edema and emphysema as main; Subacute and chronic case see pulmonary's " Macrobrachium nipponensis " sample consolidation (Cai Baoxiang chief editor, livestock epidemiology, the 3rd edition, Chinese agriculture publishing house, 1996, Beijing, 141-144).Swine enzootic pneumonia is worldwide widely current, and sickness rate is high, difficult to be eradicated, and causes the speed of growth of morbidity pig slow, and efficiency of feed utilization is low, and the feeding for fattening phase extends.Highly intensive in the modern times especially and mechanization is raised pigs in environment, and unit are hog population increases, and makes this disease be easier to spread and propagate.And suffers from the sick pig of primary disease, easily be subject to the synergism of various bacteria, virus and environmental factors, cause the compound disease of porcine respiratory (the porcine respiratory disease complex PRDC), thereby increase mortality rate, to cause one of important disease of pig industry economic loss (Li Lianren, anti-system and the health care of porcine respiratory disease complex, Hubei animal and veterinary, 2005, the 2 phases: 39-41).
Mycoplasma hyopneumoniae is mainly present in respiratory tract, lung tissue, hilar lymph node and the vertical phrenic lymph nodes of infected pigs, and sick pig and the pig that carries disease germs are its main sources of infection.Its route of transmission mainly contains: respiratory infectious, direct contact infection and droplet transmission, source of disease Jun Jin infected pigs; Initial infection mycoplasma hyopneumoniae is present in trachea and bronchus surface, and damages mucosa-cilium barrier, makes bronchus and blood vessel peripheral lymphoid like cell hypertrophy (immunoreation obviously participates in pathological development and causes lungs generation consolidation); Infected pigs mainly betides the later stage (infecting latter 15～20 weeks) of disease to the immunne response of mycoplasma hyopneumoniae, this infection has certain immunosuppressive action (Tang Li, the immunity of swine enzootic pneumonia and control, Chinese animal and veterinary digest as can be seen here, 2012,28 (4): 111).
Large-scale pig farm infectious disease is controlled the main vaccine prevention that relies at present, bio-safety, Western medicine is controlled triangular system (Shao Guoqing, the anti-pharmacy of swine enzootic pneumonia and vaccine, China's animal health, 2003, 54 (8): 21-23), but mycoplasma can change surface antigen and cause immunologic escape, a little less than causing immunity, in addition adopt the immunization route of thoracic cavity injection to be not easy to be accepted by general user, thereby be restricted on applying, so western medicine still be take as main in high infection rate kind pig farm, this sick the most frequently used Western medicine of current treatment is antibiotics, although therapeutic effect is obvious, but application antibiotic therapy easily produces drug resistance, the drug residue time is long, expense is high, and have a strong impact on growth speed of pigs, cause raiser's economic loss.
China's natural resources of Chinese medicinal materials is abundant, of a great variety, in the clinical practice of thousands of years, research worker are used compound Chinese medicinal preparation to prevent and treat infectious disease and have been obtained rich experience, have accumulated a large amount of Chinese medicine classic prescriptions: have research to adopt Venenum Bufonis to pig muscle injection, than treating with amikacin, the course for the treatment of is shorter, cure rate higher (Zhou Guangsheng, the experimental study of Chinese medicine Venenum Bufonis Injection treatment swine enzootic pneumonia, HEILONGJIANG ANIMAL SCIENCE AND VETERINARY MEDICINE, the 3rd phase in 2008: 88-89); Separately have research to use tassel Herba Moslae injection to pig muscle injection, cure rate reaches 91.6%, and the course for the treatment of is compared with amikacin short (Zhou Shoukai, the effect of Chinese medicine tassel Herba Moslae injection for treating swine enzootic pneumonia, contemporary herding, the 5th phase in 2010: 48-49); Also have report that the medical materials such as Cornus controversa, Adeps Bovis seu Bubali are made to injection to pig muscle injection, average 5 days can rehabilitation, cure rate reaches 87.5%(Zhou Guangsheng, the experimental observation of Chinese medicine Cornus controversa injection for treating swine enzootic pneumonia, China veterinary magazine, 2009,45(10): 60).But the easy secondary infection other diseases of primary disease, there is the symptoms such as dyspnea, sneeze, cough, loss of appetite, palor, fervescence, with single medicinal material, often do not have good effect, therefore according to monarch, minister, the principle helping, make, form compound recipe, play the curative effect that relieving cough and expelling phlegm is relievingd asthma.
Summary of the invention
The technical problem to be solved in the present invention is to overcome existing defect, and a kind of Chinese medicine composition of preventing and treating swine enzootic pneumonia is provided, and this Chinese medicine composition has very high cure rate to swine enzootic pneumonia.
In order to solve the problems of the technologies described above, the invention provides following technical scheme:
Prevent and treat the Chinese medicine composition of swine enzootic pneumonia, comprise the component of following weight portion:
Radix Asteris 25-40 part, Radix Stemonae 15-28 part, Semen Armeniacae Amarum 10-20 part, Cortex Mori 8-15 part, Folium Eriobotryae 10-20 part, Herba Houttuyniae 8-20 part.
Preferably, the component that comprises following weight portion:
30 parts of Radix Asteriss, 20 parts of the Radixs Stemonae, 15 parts of Semen Armeniacae Amarums, 10 parts of Cortex Mori, 15 parts of Folium Eriobotryaes, 10 parts of Herba Houttuyniae.
The preparation method of the Chinese medicine composition of control swine enzootic pneumonia, comprises the following steps:
Accurately take in proportion each medicine, be placed in container, add the water of 10 times of weight, soak 1h, decoct 2h, retain filtrate; In medicinal residues, add again the decocting of 10 times of weight to boil 2h, merge twice decoction liquor; The density that decoction liquor is concentrated into respect to water is about 1.2;
In the decoction liquor having concentrated in upper step, add 100 parts of adjuvants, the soluble starch that described adjuvant is 70% and 30% microcrystalline Cellulose; Fully mix soft material processed, cross 16 mesh sieve granule processed, 60 ℃ fully dry, and then cross 16 mesh sieve granulate, granulation agent.
The application of the Chinese medicine composition of control swine enzootic pneumonia of the present invention in preparation prevention and treatment swine enzootic pneumonia medicine.
Below beneficial effect of the present invention will be described by experiment:
Medical material component: 30 parts of Radix Asteriss, 20 parts of the Radixs Stemonae, 15 parts of Semen Armeniacae Amarums, 10 parts of Cortex Mori, 15 parts of Folium Eriobotryaes, 10 parts of Herba Houttuyniae.
After having prepared according to described method with the medical material of aforementioned proportion, carry out following experiment:
1, therapeutic test
328 of Rongchang County piglets of individual raiser's natural occurrence, Symptoms be that spirit is depressed, sagging, stand an a corner or dog shape sitting posture are breathed, asthma, cough, frequency of respiration increases severely, and is mainly and is ventral breathing, occurs that spasmodic cough even vomits in the time of seriously.Disease pig spirit is depressed, is reluctant to walk about, and poor appetite, health is become thin, and slightly disorderly, happiness is sleeping is afraid of cold fur, and body temperature and appetite change not quite and growth retardation.Cuing open the visible lung of inspection has edema and edema due to disorder of QI in various degree, and the sharp leaf of two lungs and lobus cardiacus are symmetry, confluent bronchopneumonia pathological changes.Leading edge at sharp leaf, lobus cardiacus, middle leaf and the lobus diaphragmaticus of sick Pulmonis Sus domestica portion is meat sample or Macrobrachium nipponensis sample consolidation.Hilus pulumonis and the obvious enlargement of vertical phrenic lymph nodes, matter are hard, canescence, tangent plane succulence, and other internal organs are generally without significant change.By clinical symptoms, serodiagnosis, cut open the diagnostic methods such as inspection symptom, the inspection of x-ray fluoroscopy sheet and be diagnosed as the swine enzootic pneumonia positive.Then start, with this medicine treatment, by the administration of 1g/ kg body weight spice, 2 times/day, to be used in conjunction 5d.
Result of use: sick pig cough, dyspneic symptom alleviate gradually, and spirit takes a turn for the better, searches for food, adopts water and also recover gradually normal, appetite obviously increases, after medication 5d, except 28 of seriously ill death, all the other ill pigs are cured substantially, and cure rate reaches 91.46%, and body weight gain rate is also gone up gradually.
2, protection test
Model artificial model, mycoplasma hyopneumoniae Jinan is F65 strain (China Veterinary Drugs Supervisory Inst. provides), behind Kaifeng, with Jiangsu II culture medium commercial weight, dilutes, cultivates, goes down to posterity and observe its change color, puts-20 ℃ of preservations, in 3d, uses.With being front diluted to 10
4 ~ 5ccu/ml.In the strong malicious diluent trachea of F65 with 1:50, inoculate 4 Rongchang County piglets, every 5ml, continuous 3d, swine enzootic pneumonia symptom to be occurred, and more than x-ray fluoroscopy reaches (++), the blood-letting of the sick pig carotid artery of 4 hairs is lethal, the sick lung of aseptic collection, by the sick lung+20mlHank ' s of 1:20(1g liquid) the sick lung of aseptic clip, prepare disease lung suspension, with sick lung suspension, in trachea, inoculate 50 hybridized pigs, every 4～6ml again, continuously 3d.By clinical symptoms, serodiagnosis, the methods such as inspection symptom, the inspection of x-ray fluoroscopy sheet of cuing open, judge that sickness rate is as 100%, prove that model successfully sets up.
50 of the assorted sodium selenites of long * flourish two, average weight 15.0 ± 0.2kg, mycoplasmal pneumonia of swine is negative after testing.Be divided at random 5 groups, tested medicine is high, medium and low group, control drug group, and positive controls, 10 every group, each organizes isolated rearing.Except blank group, all the other respectively organize the rear administration of equal counteracting toxic substances morbidity, and test group medicine makes an addition in feedstuff by 0.25g/ kg body weight, 0.75g/ kg body weight, 1.25g/ kg body weight dosage respectively, and feed every day at twice; Matched group medicine is also spice administration on request, be used in conjunction 5 days after drug withdrawal, continue to observe 5 days, record morbidity number and death toll, adopt X 2 test to carry out data analysis; Dead pig is cutd open inspection in time, observes its pathological change.
Result: after inoculation, the 9th day whole pig show the clinical symptoms of typical mycoplasmal pneumonia of swine, gets porcine blood serum and makes microparticle agglutination and react, and result is all positive.The inspection of x-ray fluoroscopy sheet, more than result is (++).Dead pig is cutd open inspection, and lobule sexually transmitted disease (STD) kitchen range appears in Pulmonis Sus domestica lobus cardiacus, sharp leaf, lobus diaphragmaticus, is ash dark-coloured, and that touches has hardness, is full of mucus in trachea, and other internal organs are without special variation.Tested medicine is evident in efficacy to artificial onset's swine enzootic pneumonia model, can alleviate rapidly the clinical symptoms of disease pig, has alleviated this symptom of dyspnea.From result of the test, the basic, normal, high dosage group of tested medicine is respectively 70%, 80%, 90% to the protective rate of swine enzootic pneumonia, and cure rate raises along with the increase of dosage, but with medicine matched group comparing difference not significantly (
p>0.05), between tested medicine group comparing difference also not significantly (
p>0.05).
Tested medicine shows artificial onset's swine enzootic pneumonia model gaining effect, and gaining effect increases with the increase of tested drug dose, compare with positive controls, the middle and high dosage group of tested medicine gaining effect difference extremely significantly (
p<0.01), with control drug group comparing difference not significantly (
p>0.05).
By the observation of curative effect of the swine enzootic pneumonia model to artificial onset, high, the middle dosage group of tested medicine is successful in swine enzootic pneumonia curative effect and pig weightening finish.Therefore tested medicine is suitable for the control of swine enzootic pneumonia.
The specific embodiment
embodiment 1
Prevent and treat the Chinese medicine composition of swine enzootic pneumonia, comprise the component of following weight portion:
25 parts of Radix Asteriss, 15 parts of the Radixs Stemonae, 10 parts of Semen Armeniacae Amarums, 8 parts of Cortex Mori, 10 parts of Folium Eriobotryaes, 8 parts of Herba Houttuyniae.
The preparation method of the Chinese medicine composition of control swine enzootic pneumonia, comprises the following steps:
Accurately take in proportion each medicine, be placed in container, add the water of 10 times of weight, soak 1h, decoct 2h, retain filtrate; In medicinal residues, add again the decocting of 10 times of weight to boil 2h, merge twice decoction liquor; The density that decoction liquor is concentrated into respect to water is about 1.2;
In the decoction liquor having concentrated in upper step, add 100 parts of adjuvants, the soluble starch that described adjuvant is 70% and 30% microcrystalline Cellulose; Fully mix soft material processed, cross 16 mesh sieve granule processed, 60 ℃ fully dry, and then cross 16 mesh sieve granulate, granulation agent.
embodiment 2
Prevent and treat the Chinese medicine composition of swine enzootic pneumonia, comprise the component of following weight portion:
40 parts of Radix Asteriss, 28 parts of the Radixs Stemonae, 20 parts of Semen Armeniacae Amarums, 15 parts of Cortex Mori, 20 parts of Folium Eriobotryaes, 20 parts of Herba Houttuyniae.
The preparation method of the Chinese medicine composition of control swine enzootic pneumonia, comprises the following steps:
Accurately take in proportion each medicine, be placed in container, add the water of 10 times of weight, soak 1h, decoct 2h, retain filtrate; In medicinal residues, add again the decocting of 10 times of weight to boil 2h, merge twice decoction liquor; The density that decoction liquor is concentrated into respect to water is about 1.2;
In the decoction liquor having concentrated in upper step, add 100 parts of adjuvants, the soluble starch that described adjuvant is 70% and 30% microcrystalline Cellulose; Fully mix soft material processed, cross 16 mesh sieve granule processed, 60 ℃ fully dry, and then cross 16 mesh sieve granulate, granulation agent.
embodiment 3
Best, prevent and treat the Chinese medicine composition of swine enzootic pneumonia, comprise the component of following weight portion:
30 parts of Radix Asteriss, 20 parts of the Radixs Stemonae, 15 parts of Semen Armeniacae Amarums, 10 parts of Cortex Mori, 15 parts of Folium Eriobotryaes, 10 parts of Herba Houttuyniae.
The preparation method of the Chinese medicine composition of control swine enzootic pneumonia, comprises the following steps:
Accurately take in proportion each medicine, be placed in container, add the water of 10 times of weight, soak 1h, decoct 2h, retain filtrate; In medicinal residues, add again the decocting of 10 times of weight to boil 2h, merge twice decoction liquor; The density that decoction liquor is concentrated into respect to water is about 1.2;
In the decoction liquor having concentrated in upper step, add 100 parts of adjuvants, the soluble starch that described adjuvant is 70% and 30% microcrystalline Cellulose; Fully mix soft material processed, cross 16 mesh sieve granule processed, 60 ℃ fully dry, and then cross 16 mesh sieve granulate, granulation agent.
Finally it should be noted that: the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (4)
1. a Chinese medicine composition of preventing and treating swine enzootic pneumonia, is characterized in that, by the raw material of following weight portion, is prepared:
Radix Asteris 25-40 part, Radix Stemonae 15-28 part, Semen Armeniacae Amarum 10-20 part, Cortex Mori 8-15 part, Folium Eriobotryae 10-20 part, Herba Houttuyniae 8-20 part; The preparation of described Chinese medicine composition comprises the following steps:
Accurately take in proportion each medicine, be placed in container, add the water of 10 times of weight, soak 1h, decoct 2h, retain filtrate; In medicinal residues, add again the decocting of 10 times of weight to boil 2h, merge twice decoction liquor; The density that decoction liquor is concentrated into respect to water is about 1.2;
In the decoction liquor having concentrated in upper step, add 100 parts of adjuvants, the soluble starch that described adjuvant is 70% and 30% microcrystalline Cellulose; Fully mix soft material processed, cross 16 mesh sieve granule processed, 60 ℃ fully dry, and then cross 16 mesh sieve granulate, granulation agent.
2. according to a kind of Chinese medicine composition of preventing and treating swine enzootic pneumonia described in claim 1, it is characterized in that, by the raw material of following weight portion, prepared:
30 parts of Radix Asteriss, 20 parts of the Radixs Stemonae, 15 parts of Semen Armeniacae Amarums, 10 parts of Cortex Mori, 15 parts of Folium Eriobotryaes, 10 parts of Herba Houttuyniae.
3. the preparation method of the Chinese medicine composition of the control swine enzootic pneumonia described in claim 1 or 2, is characterized in that, comprises the following steps:
Accurately take in proportion each medicine, be placed in container, add the water of 10 times of weight, soak 1h, decoct 2h, retain filtrate; In medicinal residues, add again the decocting of 10 times of weight to boil 2h, merge twice decoction liquor; The density that decoction liquor is concentrated into respect to water is about 1.2;
In the decoction liquor having concentrated in upper step, add 100 parts of adjuvants, the soluble starch that described adjuvant is 70% and 30% microcrystalline Cellulose; Fully mix soft material processed, cross 16 mesh sieve granule processed, 60 ℃ fully dry, and then cross 16 mesh sieve granulate, granulation agent.
4. the application of the Chinese medicine composition of the control swine enzootic pneumonia described in claim 1 or 2 in preparation prevention and treatment swine enzootic pneumonia medicine.
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| CN103947887B (en) * | 2014-05-09 | 2015-08-12 | 山东新希望六和集团有限公司 | A kind of feed, Chinese medicine composition and preparation method for preventing and treating swine enzootic pneumonia |
| CN104396875A (en) * | 2014-12-05 | 2015-03-11 | 融安县东起乡水产畜牧兽医站 | Synthesize prevention and control method of enzootic pneumonia of pig farms |
| CN105194375A (en) * | 2015-09-25 | 2015-12-30 | 三穗县三人游生态养殖场 | Drug for preventing pig asthma and preparation method thereof |
| CN105535248A (en) * | 2016-01-22 | 2016-05-04 | 顾志情 | Traditional Chinese medicine composition for preventing and treating swine enzootic pneumonia as well as preparation method and application of traditional Chinese medicine composition |
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| CN101780238A (en) * | 2010-04-20 | 2010-07-21 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating asthma and preparation method thereof |
| CN102657803A (en) * | 2012-05-11 | 2012-09-12 | 霍庆如 | Drug for treating child cough and preparation method thereof |
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