CN102988194B - Liposome essence - Google Patents
Liposome essence Download PDFInfo
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- CN102988194B CN102988194B CN201210524213.5A CN201210524213A CN102988194B CN 102988194 B CN102988194 B CN 102988194B CN 201210524213 A CN201210524213 A CN 201210524213A CN 102988194 B CN102988194 B CN 102988194B
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Abstract
The invention relates to a liposome essence, belonging to the technical field of cosmetics. The liposome essence comprises the following components in parts by weight: 0.5-8.0 parts of epidermal growth factor (EGF), 0.01-0.1 part of human stem cell growth factor (SCGF), 0.003-3000.0 parts of phospholipid, 0.001-10.0 parts of metallothionein, 0.001-10.0 parts of collagen, 0.01-100.0 parts of arbutin, and 0.001-200.0 parts of cholesterol. The liposome essence provided by the invention has the beneficial effects that the liposome is composed of phospholipid bilayers and contains pure water micro vesicles, and the vesicles can enclose a certain amount of nutrients and essences, are 100 nanometers in mean diameter which is 1/200-1/300 of the human cell diameter, can easily penetrate through the surface layer of human skin and can be fused with cells, thus exerting efficacy. The liposome essence can deeply humidify horny cells and enhance hydration to improve the skin softness, and can provide sufficient nutrients to ensure skin health and increase skin resistance and elasticity.
Description
Technical field
The present invention relates to a kind of liposome essence, relate in particular to and a kind ofly can solve that skin is intensely dark, flexibility decrease, aging problem and can pore convergence, smooth the liposome essence of wrinkle, belong to cosmetic product technical field.
Background technology
Skin is made up of epidermis, corium, subcutaneous fat and appendages.Epidermal area is outermost one deck of skin, is divided into from inside to outside: basal cell layer, prickle cell layer, granular cell layer, clear cell layer and horn cell layer.Skin appendages comprises hair, hair follicle, sebaceous gland and sweat gland.Skin mainly absorbs external substance by three approach, i.e. horny layer, pilosebaceous unit and the antiperspirant mouth of pipe.Its mesocuticle is the most important approach that skin absorbs, skin can only absorb some electrolyte under normal circumstances, small-molecule substance and liposoluble substance, can not directly absorb for some macro-molecular proteins, in daily life, most skin care milks are aqueous solutions, the superficial growth factor, protein, aminoacid, nucleic acid, nucleotide, the important life active compound such as vitamin is all water miscible, and the exogenous lipid of horny layer secretion and the endogenous lipid of sebaceous gland Lipid Secretion are oily matter, and water soluble nutrients chance oiliness lipid is insoluble, as shown in Figure 1, therefore cause conventional water solublity skin care item utilization rate very little, the long-term water solublity skin care item of using, easily cause nutritional labeling waste and easily stop up pore.
Summary of the invention
For overcoming the existing shortcoming of prior art, goal of the invention of the present invention is to provide a kind of liposome essence, it is taking liposome as carrying China, various nutritional labelings are carried to deep skin, fully absorbed by human body, can solve that skin is intensely dark, flexibility decrease, aging problem can make pore convergence, smooth wrinkle.
For realizing described goal of the invention, the invention provides liposome essence, the composition comprising following ratio of weight and number:
Preferably, comprise the composition of following ratio of weight and number:
Preferably, also comprise the composition of following ratio of weight and number:
Compared with prior art, liposome essence provided by the invention, it is taking liposome as carrying China, various nutritional labelings are carried to deep skin, can promote propagation and the growth of skin tissue cell, make newborn young cell substitute rapidly old and feeble dead cell, thereby solve the dim light of skin, flexibility decrease and aging problem, and can make whitening skin, wrinkle reduce.
Brief description of the drawings
Fig. 1 is the schematic diagram of the skin absorption process of the skin care item that provide in prior art;
Fig. 2 is the schematic diagram of the skin absorption process of liposome essence provided by the invention.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
This embodiment provides one can solve the dim light of skin, flexibility decrease and aging, and the liposome spermin that can make whitening skin, wrinkle reduce.Described liposome spermin comprises the composition of the weight part ratio described in following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth (SC6F) | 0.01-0.1 |
| Phospholipid | 0.003-3000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Arbutin | 0.01-100.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome essence that this embodiment provides is: phosphatidase 11 00mg, cholesterol 25mg are dissolved in 30ml ethanol (or chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting, reduction vaporization desolventizes (35 DEG C ± 1 DEG C of bath temperature) to remove, and pass into every now and then nitrogen, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mgSCGF (purchased from Peprotech company), 5mg metallothionein, 5mg collagen protein and 25mg arbutin is dissolved in 50ml deionized water (or for aqueous phosphatic, PH=6.8) and on water-bath Rotary Evaporators and constantly under rotation jolting, shakes up to obtain aqueous solution II; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, spy formula Ultrasound Instrument makes the abundant aquation 20-120 minute of lipid membrane under ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome essence of an epidermal growth factor, human stem cell growth, metallothionein, collagen protein and arbutin.
Fig. 2 is the schematic diagram of the skin absorption process of liposome essence provided by the invention.Similar to human body cell outer membrane structure and composition owing to sealing the liposome adventitia of nutritional labeling as shown in Figure 2, therefore complete liposome can gap and the direct transdermal of skin subsidiary pipeline opening through horn cell, horn cell enter site of action.Liposome provides exogenous bilayer lipid membrane, make structural change between horn cell, hydrophobicity afterbody arrangement disorder in double-layer of lipoid, fat-soluble medicine can enter intercellular substance by diffusion and capillarity, horny layer humidifying and hydration are strengthened, thereby can be penetrated easily the horny layer of epidermis and arrive each position of skin.Liposome phospholipid and Stratum corneum lipids merge changes horny layer the Nomenclature Composition and Structure of Complexes, form a kind of flat grain structure, by lipid granule gap, liposomal encapsulated medicine or nutritional labeling just enter skin, via lipid exchange, fusion, safeguard the physiological function of skin, therefore the liposome of sealing nutritional labeling or medicine has the biomembranous characteristic of human body cell and function, affect the activity of cell, to participate in human body metabolism, maintain one of necessary basic substance of human normal physiological function, there is targeting as pharmaceutical carrier, long-lasting, pardon, lipotropy and hydrophilic.Because liposome has avirulence and immunogenicity; be applicable to biological vivo degradation; can protect the entrapped superficial growth factor and human stem cell growth etc., and can carry the nutritional labelings such as the superficial growth factor and human stem cell growth and enter corium and subcutaneous tissue through horny layer.In corium and subcutaneous tissue, alleviate, the composition such as the controlled release superficial growth factor and metallothionein.Because liposome has targeting, can improve the bioavailability of the compositions such as the superficial growth factor and human stem cell growth at skin.
The liposome essence of sealing epidermal growth factor, human stem cell growth, metallothionein, collagen protein and arbutin is on probation through 100 Mies of 30 years old to 45 years old, after 20 days, 95% people's skin light is on the face gorgeous, pale, and elasticity strengthens, wrinkle reduces.
Embodiment 2
This embodiment provides a kind of dim light of skin, flexibility decrease and aging problem of enough solving, and can make whitening skin, wrinkle reduce, and can make skin keep moistening liposome spermin.Described liposome spermin comprises the composition of the weight part ratio described in following table:
| Composition | Concrete content mg/L |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth | 0.01-0.1 |
| Lipoid | 0.001-1000.0 |
| Phospholipid | 0.003-3000.0 |
| Fatty acid | 0.001-1000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Elastin laminin | 0.001-10.0 |
| Fibrous protein | 0.001-10.0 |
| Arbutin | 0.01-100.0 |
| Vitamin E | 0.001-1000.0 |
| Vitamin C | 0.001-1000.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome essence that this embodiment provides is: phosphatidase 11 00mg, lipoid 100mg, fatty acid 200mg, cholesterol 25mg and vitamin E2 5mg are dissolved in 50ml ethanol (or chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting, reduction vaporization desolventizes (35 DEG C ± 1 DEG C of bath temperature) to remove, and pass into every now and then nitrogen, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mgSCGF (purchased from Peprotech company), 5mg metallothionein, 5mg collagen protein, 5mg elastin laminin 5mg, 5mg fibrous protein, 20mg arbutin and 25mg vitamin C is dissolved in 70ml deionized water and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, spy formula Ultrasound Instrument makes the abundant aquation 20-120 minute of lipid membrane under ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome essence of the nutritional labelings such as an epidermal growth factor, human stem cell growth, metallothionein, collagen protein, elastin laminin, fibrous protein, arbutin, vitamin E and vitamin C.Preferably, described phospholipid is lecithin.
Liposome essence in the present embodiment is on probation through 100 Mies of 30 years old to 45 years old, after 15 days,, skin light is on the face gorgeous moist, pale, and elasticity strengthens, wrinkle reduces.
Embodiment 3
This embodiment provides a kind of dim light of skin, flexibility decrease and aging problem of enough solving, and can make whitening skin, wrinkle reduce and the good liposome spermin of moistening effect.Described liposome spermin comprises the composition of the weight part ratio described in following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Vascular endothelial cell growth factor (VEGF) | 0.05-8.0 |
| Hyaluronic acid | 10.0-10,000.0 |
| Stem cell factor | 0.01-0.1 |
| Lipoid | 0.001-1000.0 |
| Phospholipid | 0.003-3000.0 |
| Fatty acid | 0.001-1000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Elastin laminin | 0.001-10.0 |
| Fibrous protein | 0.001-10.0 |
| Arbutin | 0.01-100.0 |
| Barbaloin | 0.001-100.0 |
| Aminoacid | 0.001-10.0 |
| Vitamin E | 0.001-1000.0 |
| Vitamin C | 0.001-1000.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome essence that this embodiment provides is: 100mg phospholipid, 100mg lipoid, 100mg fatty acid, 25mg vitamin E and 25mg cholesterol are dissolved in 50m1 ethanol (or chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting, reduction vaporization desolventizes (35 DEG C ± 1 DEG C of bath temperature) to remove, and pass into every now and then nitrogen, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mgSCGF (purchased from Peprotech company), 1mg vascular endothelial cell growth factor (VEGF) 1000mg hyaluronic acid, 5mg metallothionein, 5mg collagen protein, 5mg elastin laminin, 5mg fibrous protein, 20mg arbutin, 20mg barbaloin, 5mg aminoacid and 25mg vitamin C is dissolved in 70ml deionized water and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, spy formula Ultrasound Instrument makes the abundant aquation 20-30 minute of lipid membrane under ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome essence of an epidermal growth factor, human stem cell growth, metallothionein, collagen protein, elastin laminin, fibrous protein, arbutin, vitamin E and vitamin C etc.
Liposome can protect the nutritional labelings such as entrapped epidermal growth factor, SCGF (purchased from Peprotech company), metallothionein, collagen protein, elastin laminin, fibrous protein, arbutin, barbaloin, aminoacid, vitamin E and vitamin C to enter corium and subcutaneous tissue through horny layer, is fully absorbed and utilizes.
The liposome essence that the present embodiment is produced is on probation through 100 Mies of 35 years old to 45 years old, and after 10 days, skin light is on the face gorgeous moist, pale, and elasticity strengthens, wrinkle reduces.After 30 days, wrinkle is almost eliminated, skin bright and cleanly moistens, mottle and freckle are obviously eliminated, and skin elasticity strengthens greatly, and will have a competition by the front obvious youth that seems.
In addition, can liposome and solution separating be opened with SephadexG50 chromatographic column if needed.
Liposome essence provided by the invention is made up of phospholipid bimolecular, include the miniature vesicle of water purification, the nutritional labelings such as can encapsulation in vesicle quantitative epidermal growth factor, metallothionein, human stem cell, its average diameter is 100 nanometers, it is 1/200～1/300 of human body cell diameter, can penetrate easily human body skin top layer, with cell fusion, performance effect.Therefore, liposome essence provided by the invention, can promote cell regeneration, solve the dim light of skin, flexibility decrease and aging problem, there is good skin care effect, can go deep into humidifying horn cell and strengthen hydration to improve the flexibility of skin, thereby can repair the normal physiological function that has the cell of damage to safeguard skin; Can provide enough nutrient to ensure the health of skin, strengthen skin resistance; Have superpower moist moisture-keeping functions, deep layer moisturizing, improves the dry water shortage status of skin.
Below the effect that describes component of the present invention, preparation method in conjunction with the embodiments in detail and reach, but embodiment illustrates the present invention for demonstrating.Description is only for explaining claims.But protection scope of the present invention is not limited to description.In the technical scope that any those skilled in the art of being familiar with disclose in the present invention, the variation that can expect easily or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (3)
1. a liposome essence, prepare by the following method: phosphatidase 11 00mg, cholesterol 25mg are dissolved in 30ml ethanol, chloroform, methanol or dichloromethane, even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting 35 DEG C ± 1 DEG C of bath temperature, and pass into every now and then nitrogen, solvent removed by evaporation at reduced pressure, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mg human stem cell growth (SCGF), 5mg metallothionein, 5mg collagen protein and 25mg arbutin is dissolved in 50ml deionized water and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, use spy formula Ultrasound Instrument under ice-water bath condition, to make the abundant aquation 20-120 minute of lipid membrane, until that emulsion becomes is transparent.
2. a liposome essence, prepare by the following method: phosphatidase 11 00mg, lipoid 100mg, fatty acid 200mg, cholesterol 25mg and vitamin E2 5mg are dissolved in 50ml ethanol, chloroform, methanol or dichloromethane, even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting 35 DEG C ± 1 DEG C of bath temperature, and pass into every now and then nitrogen, solvent removed by evaporation at reduced pressure, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mg human stem cell growth (SCGF), 5mg metallothionein, 5mg collagen protein, 5mg elastin laminin 5mg, 5mg fibrous protein, 20mg arbutin and 25mg vitamin C is dissolved in 70ml deionized water and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, use spy formula Ultrasound Instrument under ice-water bath condition, to make the abundant aquation 20-120 minute of lipid membrane, until that emulsion becomes is transparent.
3. a liposome essence, prepare by the following method: 100mg phospholipid, 100mg lipoid, 100mg fatty acid, 25mg vitamin E and 25mg cholesterol are dissolved in 50ml ethanol, chloroform, methanol or dichloromethane, even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting 35 DEG C ± 1 DEG C of bath temperature, and pass into every now and then nitrogen, solvent removed by evaporation at reduced pressure, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mg human stem cell growth (SCGF), 1mg vascular endothelial cell growth factor (VEGF), 1000mg hyaluronic acid, 5mg metallothionein, 5mg collagen protein, 5mg elastin laminin, 5mg fibrous protein, 20mg arbutin, 20mg barbaloin, 5mg aminoacid and 25mg vitamin C is dissolved in 70ml deionized water and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, use spy formula Ultrasound Instrument under ice-water bath condition, to make the abundant aquation 20-30 minute of lipid membrane, until that emulsion becomes is transparent.
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| CN201210524213.5A CN102988194B (en) | 2012-12-10 | 2012-12-10 | Liposome essence |
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| CN201210524213.5A CN102988194B (en) | 2012-12-10 | 2012-12-10 | Liposome essence |
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| CN102988194B true CN102988194B (en) | 2014-09-17 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104546639B (en) * | 2014-12-12 | 2017-11-10 | 黄宗堂 | A kind of stem cell essence and preparation method thereof |
| CN106491486A (en) * | 2016-10-26 | 2017-03-15 | 武汉汉密顿生物科技股份有限公司 | A kind of liposome turbid liquor containing the derivative liquid of cord blood stem cell and preparation method thereof and the application in cosmetics |
| CN106821789A (en) * | 2017-03-30 | 2017-06-13 | 武汉润禾生物医药有限公司 | A kind of preparation method of B B-complex nourishing cream and its liposomal thing |
| CN110916038A (en) * | 2019-11-25 | 2020-03-27 | 利和(深圳)生物科技有限公司 | Preparation method of beverage for conditioning blood health |
| CN113576937B (en) * | 2021-08-06 | 2023-01-17 | 广州药妆日用化工有限公司 | Preparation method of arbutin solid nano-liposome |
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