CN102783482B - 3-isothiazolinone composition - Google Patents
3-isothiazolinone composition Download PDFInfo
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- CN102783482B CN102783482B CN201110129863.5A CN201110129863A CN102783482B CN 102783482 B CN102783482 B CN 102783482B CN 201110129863 A CN201110129863 A CN 201110129863A CN 102783482 B CN102783482 B CN 102783482B
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Abstract
The invention relates to a 3-isothiazolinone composition. The 3-isothiazolinone composition comprises: by weight, 20 to 30% of a 3-isothiazolinone derivative, 10 to 25% of an alkali metal nitrate, 1 to 10% of an alkali metal hydrochloride, 0.001 to 0.02% of hydrogen peroxide, 0.005 to 0.01% of 2,2-dibromo-2-nitroethanol and the balance a solvent. The 3-isothiazolinone composition has excellent stability and a result of an experiment shows that the 3-isothiazolinone composition does not produce precipitates in 30 days at a temperature of 60 DEG C. The 3-isothiazolinone composition does not contain a bivalent metal salt, can be used in a dispersion solution or an emulsion or latex stably, and can effectively inhibit the growth of harmful microorganisms. Compared with the existing 3-isothiazolinone compositions, the 3-isothiazolinone composition provided by the invention has a preservation period prolonged by more than 1 time.
Description
Technical field
The present invention relates to a kind of bactericide, particularly a kind of 3-isothiazoline one compositions.
Background technology
3-isothiazolinone compounds is a kind of novel bactericide, there is efficient, wide spectrum, low toxicity, can natural degradation in environment etc. advantage, application is very extensive.But 3-isothiazolinone compounds is stable not under long-term storage condition, and As time goes on its biologically active can reduce, and affects the effect of bactericide.At present, the problem of solution bactericide stability is to add stabilizing agent in 3-isothiazolinone chemical combination.US Patent No. 3870785 has proposed to add alkaline earth nitrate, alkali metal nitrites salts etc. as the method for stabilizing agent in formula; US Patent No. 4165318 has proposed to add formaldehyde or formaldehyde releaser as the method for stabilizing agent; US Patent No. 4824957 proposes to add the organic solvent of hydroxyl as the method for stabilizing agent in isothiazolinone formula.
At present, general method is to add alkaline earth nitrate as stabilizing agent in 3-isothiazolinone derivatives, the most general with the method for magnesium nitrate used as stabilizers.Conventional formula is generally containing 1～25% isothiazolinone derivatives and 14～25% nitrate.
Yet the stabilizing agent with alkaline earth nitrate as 3-isothiazolinone product still has problems:, when joining in latex composition with the stable 3-isothiazoline one compositions of alkali salt, alkali salt can make latex occur solidifying.
Summary of the invention
The object of the present invention is to provide that a kind of adaptation is used in latex composition, 3-isothiazoline one compositions stable and reliable for performance.
The object of the invention is to realize like this: the component of 3-isothiazoline one compositions and content (percentage by weight) comprising: 3-isothiazolinone derivatives 20-30%, alkali nitrates 10-25%, alkali metal salt hydrochlorate 1-10%, hydrogen peroxide 0.001-0.02%, 2, the bromo-2-nitroethyl alcohol of 2-bis-0.005-0.01%, surplus are solvent.
3-isothiazolinone derivatives of the present invention is: CMIT, MI, the chloro-2-ethyl-3-of 5-isothiazolinone, 2-ethyl-3-isothiazolinone, 5-chloro-2-isopropyl-3-isothiazolinone, 2-isopropyl-3-isothiazolinone, 4, the chloro-MI of 5-bis-and their mixture, preferred CMIT, MI and their mixture, the ratio of CMIT and MI is conventionally between 2.5～4.0, the content of 3-isothiazolinone derivatives is 1～30%, 25-27% preferably.Alkali nitrates is sodium nitrate, potassium nitrate, lithium nitrate and ammonium nitrate, is preferably sodium nitrate or potassium nitrate, and the content of alkali nitrates is 10～25%, preferably 15-20%.Alkali metal salt hydrochlorate is sodium chloride or potassium chloride, and the content of alkali metal salt hydrochlorate is 1-10%.In component of the present invention, add a certain amount of hydrogen peroxide and 2, the bromo-2-nitroethyl alcohol of 2-bis-, can significantly improve the stability of 3-isothiazolinone derivatives, under both actings in conjunction, make the storage that the 3-isothiazolinone derivatives of 20% above concentration can be for a long time stable, and can be used in emulsion or latex or dispersion liquid, can not form and solidify.Described solvent is water, propane diols, dipropylene glycol and their mixture.Be preferably water, be not limited to this several solvents.
Feature of the present invention is: have excellent stability, experimental result is given under the temperature condition of 60 ℃, deposit 30 days precipitation form; In composition, not containing divalent metal salt, stable being used in dispersion liquid or emulsion or latex of energy, effectively suppresses harmful microbe growth; Compare with existing 3-isothiazoline one compositions, the holding time can extend more than one times.
Embodiment
Embodiment 1
Embodiment 2
| Component | Content (percentage by weight) |
| 3-iso thiazoline ketone compound | 25.0 |
| Potassium nitrate | 20.0 |
| Potassium chloride | 7.4 |
| Hydrogen peroxide | 0.005 |
| The bromo-2-nitroethyl alcohol of 2,2-bis- | 0.01 |
| Water and dipropylene glycol | 47.59 |
Embodiment 3
| Component | Content (percentage by weight) |
| 3-iso thiazoline ketone compound | 27.5 |
| Lithium nitrate | 19.0 |
| Potassium chloride | 7.0 |
| Hydrogen peroxide | 0.009 |
| The bromo-2-nitroethyl alcohol of 2,2-bis- | 0.01 |
| Water and propane diols | 46.48 |
Embodiment 4
| Component | Content (percentage by weight) |
| 3-iso thiazoline ketone compound | 30.0 |
| Ammonium nitrate | 25.0 |
| Sodium chloride | 10.0 |
| Hydrogen peroxide | 0.02 |
| The bromo-2-nitroethyl alcohol of 2,2-bis- | 0.01 |
| Water and propane diols | 34.97 |
Component of the present invention and content are not limited to above-described embodiment, can within the scope of it, prepare.
The technical process of preparation 3-isothiazoline one compositions is: 3-isothiazoline keto hydrochloride is dissolved in the alkali nitrates aqueous solution, with alkali carbonate, neutralize pH=2.0-5.0, add the bromo-2-nitroethyl alcohol of 2,2-bis-, hydrogen peroxide, 3-isothiazolinone composition product stirs to obtain.
The sample of embodiment 1-4 configuration is placed after 30 number of days at 65 ℃, with high performance liquid chromatography (HPLC), analyzed main active ingredient CMIT (CMIT), the content of MI (MIT), the results are shown in following table.
As can be seen from Table 2, add the hydrogen peroxide of proper proportion and the sample of the bromo-2-nitroethyl alcohol of 2,2-bis-, very little in 30 days active ingredient change in concentration of 65 ℃ of placements, the 3-isothiazoline one compositions the present invention relates to has obvious stablizing effect.
Claims (2)
1. a 3-isothiazoline one compositions, the component and the content (percentage by weight) that it is characterized in that it comprising: 3-isothiazolinone derivatives 20-30%, the sodium nitrate 10-25%, sodium chloride 1-10%, the hydrogen peroxide 0.001-0.02%, 2 that CMIT and MI, consist of, the bromo-2-nitroethyl alcohol of 2-bis-0.005-0.01%, surplus are water.
2. 3-isothiazoline one compositions according to claim 1, the content that it is characterized in that 3-isothiazolinone derivatives is 25-27%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201110129863.5A CN102783482B (en) | 2011-05-19 | 2011-05-19 | 3-isothiazolinone composition |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110129863.5A CN102783482B (en) | 2011-05-19 | 2011-05-19 | 3-isothiazolinone composition |
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| Publication Number | Publication Date |
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| CN102783482A CN102783482A (en) | 2012-11-21 |
| CN102783482B true CN102783482B (en) | 2014-10-22 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142592B (en) * | 2013-02-01 | 2014-09-17 | 上海海洋大学 | Medicine for preventing fish saprolegniasis and application thereof |
| CN103734184A (en) * | 2013-12-09 | 2014-04-23 | 乌鲁木齐德安东升环保设备有限公司 | Multiple-effect sterilizing agent and preparation method thereof |
| CN107136098A (en) * | 2017-05-27 | 2017-09-08 | 四川奥恒环保科技有限公司 | A kind of Biocidal algae-killing agent |
| CN109964947A (en) * | 2019-04-12 | 2019-07-05 | 嘉兴沃特泰科环保科技有限公司 | Non-oxidative antimicrobial |
| CN115043761B (en) * | 2022-07-06 | 2024-03-19 | 湖南丽臣奥威实业有限公司 | Process for producing triethanolamine alkyl sulfate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3870795A (en) * | 1973-02-28 | 1975-03-11 | Rohm & Haas | Stabilization of solutions of 3-isothiazolones employing certain metal nitrates and nitrites |
| EP0436744B2 (en) * | 1989-11-10 | 2001-09-26 | Thor Chemie Gmbh | Stabilized aqueous solutions of 3-Isothiazolinones |
| JP3585263B2 (en) * | 1994-07-29 | 2004-11-04 | ソマール株式会社 | Industrial antibacterial agent |
| CN100581641C (en) * | 2006-03-20 | 2010-01-20 | 天津化工研究设计院 | Bactericide for reverse osmosis membrane and method for preparing the same |
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Address after: Dalian Lushun 116052 export of Liaoning Province Economic Development Zone Shunle Street No. 325 Applicant after: Dalian Bio-Chem Co., Ltd. Address before: Dalian Lushun 116052 export of Liaoning Province Economic Development Zone Shunle Street No. 325 Applicant before: Dalian Bio Chemical Co., Ltd. |
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