CN102698672B - Microfluidic reactor - Google Patents
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- CN102698672B CN102698672B CN201210159002.6A CN201210159002A CN102698672B CN 102698672 B CN102698672 B CN 102698672B CN 201210159002 A CN201210159002 A CN 201210159002A CN 102698672 B CN102698672 B CN 102698672B
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Abstract
The invention discloses a microfluidic reactor which comprises a base, a reaction pool plate, a slide, a rubber ring and a spiral cover. The base, the reaction pool plate and the slide form a complete reaction chamber; the spiral cover is horizontally pressed on the slide through the buffering of the rubber ring to seal the reaction chamber. Due to the bionic design of a fusiform reaction pool on the reaction pool plate, the flow field is distributed uniformly during the flow of the fluid in the reaction chamber, and no fluid is left during discharge. The microfluidic reactor can not be affected by the placement azimuth and can be also used for the reaction needing temperature controlling and lighting. The microfluidic reactor can be widely used for the microfluidic reaction experiments in various fields including the biological field, the chemical field, the medical field and the like.
Description
Technical field
The invention discloses a kind of micro-fluid reactor, particularly a kind of Flow Field Distribution evenly, without raffinate, can temperature control micro-fluid reactor.Belong to microfluid biochemical reaction instrument preparing technical field.
Background technology
Micro-fluid reactor is as the main place of microfluid biochemical reaction, and its performance quality directly has influence on the result of reaction.In complete biochemical reaction, the general plurality of reagents of all need to carrying out in same reative cell is alternately filled the multi-step reaction of changing, but when entering reative cell, the liquid of trace causes the change of flow velocity due to the variation of sectional area, and while flowing in reative cell, can be subject to frictional resistance, add some capillary siphonages, be easy to cause rate of flow of fluid uneven, Flow Field Distribution is inconsistent, after making fluid be filled with reative cell, cause density unevenness even cannot be full of, and have raffinate while discharging from reative cell, and cause the cross pollution of reagent, affect reaction result.For alleviating raffinate problem, place in the orientation that generally reaction tank is designed to vertical or inclination certain angle in pre-existing reactors, as Chinese invention patent (application number 200510024234.0) discloses a kind of device of accelerating biological chip micro fluid reaction, wherein the entrance of reaction cabin used must have certain angle with outlet line, otherwise air can not promote liquid flow and produce bubble.But need to be in the experiment of reaction tank horizontal positioned at some, such reaction tank can not meet the demands.Based on this, be necessary to design a kind of azimuthal influence of not placed, when in realization response chamber, fluid flows, Flow Field Distribution is even, during discharge without the micro-fluid reactor of raffinate.
Summary of the invention
The object of the invention is to overcome the deficiency of prior art and provide a kind of simple and reasonable, processing and manufacturing easily, not placed azimuthal influence, when in realization response chamber, fluid flows, Flow Field Distribution is even, during discharge without the micro-fluid reactor of raffinate.
A kind of micro-fluid reactor of the present invention, comprise: pedestal, reaction tank plate, slide, rubber ring and spiral cover, on described pedestal, be stacked with successively reaction tank plate, slide, described spiral cover spinning is fitted on described slide on described pedestal and by described rubber ring, it is characterized in that: described reaction tank plate middle part is provided with the reaction tank of a similar fusiformis, the two ends of described reaction tank length direction are respectively provided with an inlet opening, fluid hole, and described inlet opening, fluid hole and feed pathway or the liquid outlet channel be located on pedestal are corresponding.
In a kind of micro-fluid reactor of the present invention, described reaction tank shape Central Symmetry, middle wide, two ends are narrow, similar fusiformis; The two ends of described reaction tank and inlet opening or fluid hole profile intersect at a C, C ', D, D ', form inlet or the liquid outlet of reaction tank, and the width C C ' of described inlet or liquid outlet or DD ' are: 0.2-6mm; The outline line at reaction tank middle part is straight line AB and straight line A ' B ', and the length of straight line AB or straight line A ' B ' is 2-60mm, and the spacing between straight line AB and straight line A ' B ' is 2-60mm; Described straight line AB or straight line A ' B ' two ends are passed through respectively circular arc BC, AD or B ' C ', A ' D ', are connected with end points C, D or C ', the D ' of reaction tank; In described circular arc BC, AD, B ' C ', A ' D ', circular arc BC or B ' C ' be some C, a B, 3 of E or some C ', B ', 3 of E ' and with straight line AB or the tangent circular arc of A ' B ', described some E or E ' are that a C or C ' be take the symmetric points that BB ' is axle; Circular arc AD or A ' D ' be some D, an A, 3 of F or D ', A ', 3 of F ' and with straight line AB or the tangent circular arc of A ' B ', described some F or F ' are that a D or D ' be take the symmetric points that AA ' is axle.
In a kind of micro-fluid reactor of the present invention, angle ∠ ABC, ∠ A ' B ' C ', ∠ BAD, ∠ B ' A ' D ' that the line between described some A, B, C, D, A ', B ', C ', D ' forms are 135-165 degree.
In a kind of micro-fluid reactor of the present invention, described reaction tank plate upper and lower surface is smooth, smooth; Lower surface has outstanding locating dowel and the locating hole of being located on pedestal to match.
In a kind of micro-fluid reactor of the present invention, be located at the inlet opening on pedestal, inlet and the liquid outlet that fluid hole is communicated in respectively pedestal side.
In a kind of micro-fluid reactor of the present invention, described pedestal is provided with a draw-in groove, and draw-in groove middle part is provided with an internal thread, and described reaction tank plate, slide are inlaid in described draw-in groove, and there is external screw thread described spiral cover outer ring, and spinning is on described internal thread.
In a kind of micro-fluid reactor of the present invention, in the middle of described spiral cover, be provided with and can make the freely through hollow structure of illumination, lower surface is provided with a groove, and described rubber ring is nested in described groove.
In a kind of micro-fluid reactor of the present invention, described pedestal side is provided with the embedded hole of electrical bar and temperature sensor, and the electrical bar and the temperature sensor that are electrically connected to peripheral hardware control system are inlaid in described embedded hole.
Operation principle of the present invention is summarized as follows:
On described pedestal, be stacked with successively reaction tank plate, slide, described spiral cover spinning is on described pedestal, and three has formed complete reative cell, and is fitted on slide reaction tank is airtight by being inlaid in the rubber ring of spiral cover bottom; Described reaction tank plate middle part is provided with a similar fusiformis, the reaction tank of bottomless, uncovered; Because reaction tank is in shape, it from port to centre, is one section of smooth circular arc relaxing gradually, from port to centre, be that one section of straight line is compared with conventional reaction tank, can make the fluid that porch relative velocity is higher well be spread at y direction, be full of faster whole reaction tank, thereby the flow velocity that is conducive to X direction reduces and is tending towards evenly, obtaining very soon the flow field that flow velocity homogeneous distributes, from but solution reaction tank, evenly advance, without raffinate.Reaction tank prepared by the present invention, fluid is flow velocity homogeneous in reative cell, Flow Field Distribution is even, while making fluid expulsion reative cell without raffinate.
Because reaction tank plate upper and lower surface is all smooth, smooth, can be smooth, tight be placed on described pedestal, makes slide, reaction tank plate, pedestal by spinning spiral cover on internal thread in the middle of draw-in groove, and three has formed complete enclosed reaction chamber; Spiral cover upper surface has swing arm, and turn swing arm can make spiral cover level on draw-in groove move down, and then guarantees the slide uniform stressed of below pressurized.Be inlaid in the rubber ring in described spiral cover lower surface groove, can play cushioning effect.
Reaction tank plate lower surface has outstanding locating dowel, and described pedestal upper surface has the locating hole matching with it, can the accurate location of realization response pond plate on pedestal.
Described pedestal upper surface has inlet opening and the fluid hole that is communicated in respectively side inlet and liquid outlet, and its liquid hole site is corresponding with the two-port that is positioned at the reaction tank on pedestal respectively with shape size.Pedestal upper surface is smooth, smooth, has formed the end of reative cell, is beneficial to fluid smooth and easy mobile.
Described pedestal is provided with draw-in groove, and its spacing and slide are suitable, can play location and the fixation of slide.
In the middle of described spiral cover, be hollow structure, can in the experiment that needs illumination condition, make required light path freely pass through, can also see through the indoor situation of slide observing response.
There is the embedded hole of electrical bar or temperature sensor described pedestal side, can embed the electrical bar or the temperature sensor that controlled by circuit, by the temperature of peripheral hardware control system realization response chamber, controls.
Beneficial effect of the present invention sketch under:
The present invention has designed a kind of micro-fluid reactor, comprises pedestal, reaction tank plate, slide, rubber ring and spiral cover.Because reaction tank has adopted bionic design, port is one section of smooth circular arc relaxing gradually to centre, making reaction tank global shape is the fusiformis of similar fish, can make thus the fluid that porch relative velocity is higher well to periphery, spread, so can obtain very soon the flow field that flow velocity homogeneous distributes, the reaction tank of this fusiformis is compared with conventional rhombus reaction tank, has improved homogeneity.Due to being uniformly distributed of flow field velocity, fluid homogeneous in reaction tank is advanced, concentration is even, during discharge without remnants.So this reactor is not placed azimuthal influence, can level, vertically or place arbitrarily by other orientation angles.
The screw fixation method design of spiral cover is subject to force level even while making reative cell airtight.The hollow structure of spiral cover, can realize and in reative cell, carry out illumination reaction and can observe reaction process.Adding of function of temperature control also makes this reactor have applicability widely.It is simple that multiple Position Design makes reactor monolith assembling simultaneously, can be widely used in the micro fluid reaction experiment in each fields such as biology, chemistry, medicine.
Accompanying drawing explanation
Accompanying drawing 1 is micro-fluid reactor decomposing schematic representation:
Accompanying drawing 2 is assembling schematic diagrames of micro-fluid reactor:
Accompanying drawing 3 is pedestal schematic diagrames:
Accompanying drawing 5 is spiral cover schematic diagrames:
Accompanying drawing 6 is that reaction tank shape forms schematic diagram:
Accompanying drawing 7 is reaction tank, hot spot and spiral cover inner edge relative position schematic diagram:
Accompanying drawing 8 is conventional rhombus reaction tank;
Accompanying drawing 9 is fusiformis reaction tank of the present invention;
Accompanying drawing 10-1 is the contoured velocity cloud charts of conventional rhombus reaction tank;
Accompanying drawing 10-2 is the contoured velocity cloud charts of fusiformis reaction tank of the present invention;
Specific implementation method
Below in conjunction with accompanying drawing and and embodiment the present invention is described in further detail:
Embodiment 1
Referring to accompanying drawing 1-10, a kind of micro-fluid reactor, comprise: pedestal 10, reaction tank plate 20, slide 30, rubber ring 40 and spiral cover 50, described reaction tank plate 20 is placed on pedestal 10, described slide 30 covers on described reaction tank plate 20, three has formed complete reative cell, and by described spiral cover 50 levels, is pressed on slide reative cell is airtight by described rubber ring 40 bufferings.
Described pedestal 10 upper surfaces have dark 2.2mm, the cuboid locating hole 15 of length of side 2mm, the accurate location that reaction tank plate 20 can be realized on pedestal 10 by locating dowel 21 and locating hole 15, pedestal 10 upper surfaces are smooth smooth, the circular hole that has two radius 0.9mm, one is inlet opening 13, and another is fluid hole 14, corresponding identical with inlet 22 and the liquid outlet 23 of reaction tank 24 respectively.Inlet opening 13, fluid hole 14 are communicated in respectively inlet 11 and the liquid outlet 12 of pedestal 10 sides, the screwed hole that inlet 11 and liquid outlet 12 are 10-32 made in U.S.A, and can being 1/16 by hand-tight joint and external diameter, " teflon pipe (1.5875mm) be connected.
Bossed draw-in groove 17 on pedestal 10, separation 25mm, high 8mm, can be by wide 25mm, long 75mm, slide 30 location of thick 1mm, slide 30 pastes and covers on reaction tank plate 20 tops, with the reative cell of reaction tank plate 20 complete together with pedestal 10.
Reative cell by spiral cover 50 be pressed on slide 30, carry out airtight.The high 8mm of described spiral cover 50, is with the external screw thread 53 of diameter 34mm outward, and upper surface has two swing arms 51.On described pedestal draw-in groove 17, have the internal thread 16 of the diameter 34mm identical with spiral cover 50, turn swing arm 51, can make spiral cover 50 levels be pressed on slide 30 downwards, and slide 30 is stressed evenly, has guaranteed the intact airtight of reative cell.
Described spiral cover 50 lower surfaces have an annular groove 52, can nested inside radius 12.6mm, and the rubber ring 40 of outer radius 15mm, plays cushioning effect.
In the middle of described spiral cover 50, be the cylinder 54 of hollow, internal diameter is 20mm, can make required light path freely pass through in the experiment that needs illumination condition, can also see through the indoor situation of slide observing response.As shown in Figure 7, be 14.0288mm * 10.5216mm(4:3) the relative position schematic diagram of hot spot 70 and spiral cover cylinder 54 edges and reaction tank 24.
There are electrical bar embedded hole 19 and temperature sensor embedded hole 110 in described pedestal 10 sides, can embed respectively the electrical bar or the temperature sensor that controlled by circuit, by peripheral hardware control system realization response temperature, control.
Adopt Fluent cfdrc to carry out modeling and simulating to the fusiformis reaction tank of the present embodiment conventional rhombus reaction tank corresponding with parameter.For simplified model, feed liquor and the liquid outlet channel of reaction tank replace with rectangle, the long 1.8mm of described rectangular channel, wide 1.2mm, corresponding with reaction tank two ends (as shown in Figure 8, Figure 9).The entrance flow velocity boundary condition of emulation is 5mm/s, the Contrast on effect of simulation result is selected the mid-plane of 0.5mm At The Height, analyze the VELOCITY DISTRIBUTION isopleth cloud atlas of this plane (as Figure 10-1, shown in Figure 10-2), reduced parameter is selected evening ratio R, and wherein, A represents the area in the flow field of speed between 0.47-0.95mm/s in reaction zone to R=A/T., be even area, T represents the gross area of whole reaction tank.In rhombus reaction tank, evenly area A is 204.3mm
2, gross area T is 298.1mm
2, evening ratio R=204.3/298.1=68.53%.
In fusiformis reaction tank, evenly area A is 260.2mm
2, gross area T is 366.1mm
2, evening ratio R=260.2/336.1=77.42%.Visible, the evening ratio of fusiformis reaction tank is larger, illustrates that the even effect of fusiformis reaction tank is better than conventional rhombus reaction tank.
The structure of embodiment 2 is identical with embodiment 1, and concrete structure parameter is:
∠ ABC, ∠ A ' B ' C ', ∠ BAD, ∠ B ' A ' D ' are 135 degree.Described straight line AB and the long 2mm of straight line A ' B ', the spacing between straight line AB and straight line A ' B ' is 2mm.The width C C ' of reaction tank inlet or liquid outlet and DD ' are 0.2mm, the long 0.3mm of rectangular channel.Reaction tank gross area T is about 7mm
2.With entrance velocity 5mm/s, carry out Fluent analog simulation, the even area A of the even speed obtaining between 0.46-0.92mm/s is 5.4mm
2, evening ratio R(A/T) and be 77.14%; Contrast corresponding conventional rhombus pond, reaction tank gross area T is 6.1mm
2, evenly area A is 4mm
2, evening ratio R is 65.57%.In this embodiment, the evening ratio of fusiformis reaction tank is larger, illustrates that the even effect in fusiformis pond is better than conventional rhombus reaction tank.
The structure of embodiment 3 is identical with embodiment 1, and concrete structure parameter is:
∠ ABC, ∠ A ' B ' C ', ∠ BAD, ∠ B ' A ' D ' are 165 degree.Described straight line AB and the long 60mm of straight line A ' B ', the spacing between straight line AB and straight line A ' B ' is 50mm, the width C C ' of reaction tank inlet or liquid outlet and DD ' they are 6mm, the long 9mm of rectangular channel.Reaction tank gross area T is about 8979mm
2.With entrance velocity 50mm/s, carry out Fluent analog simulation, obtaining the even area A of even speed between 7.2-10.9mm/s is 6079mm
2, evening ratio R(A/T) and be 67.70%; Contrast corresponding conventional rhombus pond, reaction tank gross area T is 7706mm
2, evenly area A is 4210mm
2, evening ratio R is 54.63%.In this embodiment, the evening ratio of fusiformis reaction tank is larger, illustrates that the even effect in fusiformis pond is better than conventional rhombus reaction tank.
The structure of embodiment 4 is identical with embodiment 1, and concrete structure parameter is:
The high 1mm of reaction tank, described straight line AB and the long 16mm of straight line A ' B ', the spacing between straight line AB and straight line A ' B ' is 12mm, the width C C ' of reaction tank inlet or liquid outlet and DD ' they are 2mm, the long 3mm of rectangular channel.The entrance flow velocity boundary condition of emulation is 5mm/s,
Adopt Fluent cfdrc to carry out modeling and simulating to the fusiformis reaction tank of the present embodiment conventional rhombus reaction tank corresponding with parameter, emulation subtended angle ∠ ABC is respectively 125 degree, 135 degree, 145 three group models while spending.In order to obtain the optimal solution of fusiformis reaction tank shape, the subtended angle ∠ ABC that continues increase fusiformis pond carries out modeling and simulating to 148 degree and 152 degree simultaneously.The Contrast on effect of simulation result is selected the mid-plane of 0.5mm At The Height, analyze the VELOCITY DISTRIBUTION isopleth cloud atlas of this plane, reduced parameter is selected evening ratio R, R=A/T. wherein, A represents the area in the flow field of speed between 0.9-1.4mm/s in reaction zone, be even area, T represents the gross area of whole reaction tank.
Simulation result is in Table 1, as can be drawn from Table 1: in three groups of contrast simulations, the R value of fusiformis reaction tank is greater than the R value of corresponding rhombus reaction tank, the even effect that fusiformis reaction tank of the present invention is described is better than conventional rhombus reaction tank: when the subtended angle ∠ ABC in fusiformis pond spends from 125 degree to 152, R value first increases and then decreases, maximum while spending to 145.Further increase subtended angle, the value increase of even area approaches saturated, but the increase of the gross area reduces R value, has also wasted reaction reagent, and in the present embodiment, 145 degree are optimal solution.
Table 1 is the data statistics obtaining after conventional rhombus reaction tank and fusiformis reaction tank fluent of the present invention emulation.
Table 1
The above embodiment has only expressed embodiments of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction of the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (7)
1. a micro-fluid reactor, comprise: pedestal, reaction tank plate, slide, rubber ring and spiral cover, on described pedestal, be stacked with successively reaction tank plate, slide, described spiral cover spinning is fitted on described slide on described pedestal and by described rubber ring, it is characterized in that: described reaction tank plate middle part is provided with the reaction tank of a similar fusiformis, the two ends of described reaction tank length direction are respectively provided with an inlet opening, fluid hole, and described inlet opening, fluid hole and feed pathway or the liquid outlet channel be located on pedestal are corresponding; Described reaction tank shape Central Symmetry, middle wide, two ends are narrow, similar fusiformis; The two ends of described reaction tank and inlet opening, fluid hole profile intersect at a C, C ', D, D ', form inlet or the liquid outlet of reaction tank, and the width C C ' of described inlet or liquid outlet or DD ' are: 0.2-6mm; The outline line at reaction tank middle part is straight line AB and straight line A ' B ', and the length of straight line AB or straight line A ' B ' is 2-60mm, and the spacing between straight line AB and straight line A ' B ' is 2-60mm; Described straight line AB or straight line A ' B ' two ends are passed through respectively circular arc BC, AD or B ' C ', A ' D ', are connected with end points C, D or C ', the D ' of reaction tank; In described circular arc BC, AD, B ' C ', A ' D ', circular arc BC or B ' C ' be some C, a B, 3 of E or some C ', B ', 3 of E ' and with straight line AB or the tangent circular arc of A ' B ', described some E or E ' are that a C or C ' be take the symmetric points that BB ' is axle; Circular arc AD or A ' D ' be some D, an A, 3 of F or D ', A ', 3 of F ' and with straight line AB or the tangent circular arc of A ' B ', described some F or F ' are that a D or D ' be take the symmetric points that AA ' is axle.
2. a kind of micro-fluid reactor according to claim 1, is characterized in that: angle ∠ ABC, ∠ A ' B ' C ', ∠ BAD, ∠ B ' A ' D ' that the line between described some A, B, C, D, A ', B ', C ', D ' forms are 135-165 degree.
3. a kind of micro-fluid reactor according to claim 2, is characterized in that: described reaction tank plate upper and lower surface is smooth, smooth; Lower surface has outstanding locating dowel and the locating hole of being located on pedestal to match.
4. a kind of micro-fluid reactor according to claim 3, is characterized in that: be located at the inlet opening on pedestal, inlet and the liquid outlet that fluid hole is communicated in respectively pedestal side.
5. a kind of micro-fluid reactor according to claim 4, it is characterized in that: described pedestal is provided with a draw-in groove, draw-in groove middle part is provided with an internal thread, and described reaction tank plate, slide are inlaid in described draw-in groove, there is external screw thread described spiral cover outer ring, and spinning is on described internal thread.
6. a kind of micro-fluid reactor according to claim 5, is characterized in that: in the middle of described spiral cover, be provided with and can make the freely through hollow structure of illumination, lower surface is provided with a groove, and described rubber ring is nested in described groove.
7. a kind of micro-fluid reactor according to claim 6, is characterized in that: described pedestal side is provided with the embedded hole of electrical bar or temperature sensor, and the electrical bar or the temperature sensor that are electrically connected to peripheral hardware control system are inlaid in described embedded hole.
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| CA2896997C (en) | 2013-01-03 | 2023-10-03 | Brigham And Women's Hospital, Inc. | System and method for a biomimetic fluid processing |
| CN103217326B (en) * | 2013-03-28 | 2015-05-13 | 广州安必平医药科技股份有限公司 | Sample reaction cabin and detection reagent adding method |
| WO2015153451A1 (en) | 2014-03-31 | 2015-10-08 | Brigham And Women's Hospital, Inc. | Systems and methods for biomimetic fluid processing |
| CN104888678A (en) * | 2015-06-16 | 2015-09-09 | 上海和伍复合材料有限公司 | Microreactor adopting conical non-laminated structure |
| CN105536669A (en) * | 2016-01-21 | 2016-05-04 | 华东理工大学 | Detachable micro-channel reactor |
| CN108286076B (en) * | 2018-04-17 | 2024-09-20 | 中南大学 | Biochip in-situ preparation system and application method thereof |
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| JP4367283B2 (en) * | 2004-08-06 | 2009-11-18 | 株式会社日立プラントテクノロジー | Microfluidic chip |
| CN1316040C (en) * | 2005-03-07 | 2007-05-16 | 上海百傲科技有限公司 | Device and method for accelerating biological chip micro fluid reaction |
| JP5245831B2 (en) * | 2006-11-01 | 2013-07-24 | コニカミノルタエムジー株式会社 | Microchip and microchip inspection system |
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