CN102466581A - Device - Google Patents
Device Download PDFInfo
- Publication number
- CN102466581A CN102466581A CN2010105380761A CN201010538076A CN102466581A CN 102466581 A CN102466581 A CN 102466581A CN 2010105380761 A CN2010105380761 A CN 2010105380761A CN 201010538076 A CN201010538076 A CN 201010538076A CN 102466581 A CN102466581 A CN 102466581A
- Authority
- CN
- China
- Prior art keywords
- sample
- sample chamber
- chamber
- valve
- air pressure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The invention provides a device, comprising a sample cavity, a fluid flowing controller and an air booster, wherein the sample cavity is connected with the fluid flowing controller; and the air booster is used for boosting the inner air pressure of the sample cavity. Because a pressure in the sample cavity is large than an external pressure, fluid in the sample cavity can smoothly flow outside the sample cavity; especially, when less samples exist, due to the existence of the pressure of the sample cavity, a flow rate and a flow velocity of the fluid are ensured, the amount of samples needing being detected for the next step is ensured, and the accuracy of detection is ensured; in addition, samples can fast flow out of the sample cavity due to the boosted air pressure, thus the efficiency of processing the samples is provided, and the time of finishing the whole detection is saved on the whole. The device disclosed by the invention can be further combined with a collector and a detector to integrate functions of sample collection, processing and detection into a whole. The device disclosed by the invention has the advantages of handiness and convenience for transporting and carrying, and in particular is suitable for families.
Description
Technical field
The present invention relates to handle the device of sample, especially sample needs pretreated device before detection;
And the method for using this apparatus processes sample.
Background technology
The various sample collections of clinical use or family expenses and the proving installation of extraction all have in the document and description to some extent.These proving installations can utilize a kind of in the various collection kits to obtain sample and it is transferred to storage.Can extract sample from gathering-device, then sample is sent to testing element to confirm whether existing of certain material, for example detection of analytes.These devices can be used for target classification, comprise detection of drugs and biologic artifact, for example glucose or hormone, antibody or cause of disease.Usually, need the sample existence form of detection various, like solid, semisolid; Liquid or gas or the like, they can't detect under original state; Perhaps testing result is undesirable, need change their physics or chemical characteristic usually through pre-service, for example; Help dilution or cushion these samples through buffer solution, then, detect again.
Summary of the invention
The problem that the present invention will solve provides a kind of device, when using this device, can increase flow, the particularly sample size flow more after a little while of handling the back or being stored in the fluid sample outflow sample chamber in the device, and the time of bleeder; Guarantee accuracy and the efficient that improves whole detection of next step detection, the shortening time.This device can be to processing before the pattern detection or storing fluid sample.
On the one hand, the present invention provides a kind of device, comprising: be used to collect, the sample chamber of processing or storing sample; The device of control fluid flow; With the device that increases the sample chamber internal gas pressure; Wherein, sample chamber is connected with the device of control fluid flow.In a preferred mode, the air pressure that increases in the sample chamber forces the fluid that is positioned at sample chamber to flow out to outside the sample chamber through the device of controlling fluid flow.This sample chamber both can be used for collecting fluid sample, also can fluid sample handle, and can also be used to collecting and store fluid sample, the perhaps set of any two functions of three functions.These functions have detailed description below.
In another preferred mode; The device of control fluid flow has the primary importance and the second place; When it is in primary importance; Fluid in the sample chamber can not flow out through this fluid control device, and when being in the second place, the fluid in the sample chamber can flow out to outside the sample chamber through this fluid control device.Preferred, when the device of control fluid flow was in primary importance, the air pressure in the sample chamber increased; When the device of control fluid flow was in the second place, the air pressure of increase forced the part sample to flow out to outside the sample chamber.
In another preferred mode, after in the sample entering sample chamber, the device that increases air pressure increases the sample chamber internal pressure, and behind the device of opening the control fluid flow, the air pressure of increase forces the part sample to flow to outside the sample chamber.
In some embodiments, sample chamber comprises first and second openings, and wherein first opening is used for receiving sample; Second opening is connected with the device of control fluid flow.More excellent, sample chamber first opening and the means for engaging that increases air pressure are used for increasing the air pressure in the sample chamber.
In another preferred mode, the device of control fluid flow has the sample chamber of letting and the external world is in sealing or two states of non-tight.Sample gets in the sample chamber; The device that increases air pressure increases the air pressure in the sample chamber; When after sample process is accomplished, maybe need detect, the device of control fluid flow makes sample chamber be in communication with the outside (non-tight state), at this moment, because of the pressure ratio external atmospheric pressure in the sample chamber is big, impels the fluid in the chamber to flow out to outside the chamber automatically.Even sample size is more after a little while, because of the air pressure in the sample chamber, but sample also dependable flow and flow velocity when flowing out, also can guarantee to let simultaneously most samples since gas pressure force and be rejected to outside the sample chamber.The present invention is through the device of control circulation flow and the cooperation that increases the device of air pressure, make sample chamber sealed and the chamber in air pressure increase, thereby make when sample chamber is in communication with the outside that the fluid in the chamber flows to outside the sample chamber automatically.Like this, the flow that fluid sample flows out and speed are that the flow and the speed that flow out normal barometric pressure under are big than sample chamber, have further guaranteed the quantity of detection sample needs, guarantee the accuracy that detects, have shortened the time of whole detection simultaneously, have improved detection efficiency.
" device of control fluid flow " of the present invention has control sample chamber and sample chamber inner fluid and the extraneous effect that whether is communicated with.This device can have multiple mode and realize such effect.For example can be the baffle plate that can extract, it is positioned at a port of sample chamber, can make sample chamber and interior fluid thereof be in communication with the outside through extracting baffle plate out.Or the film that can puncture, an end port of its sealing sample chamber when needs circulate, punctures this film, and sample fluid is flowed out through this film that punctures.In one embodiment, the device of this control fluid flow can be the valve that links to each other with sample chamber, controls sample chamber and whether the external world circulates through the opening and closing of valve.In a concrete embodiment, valve has the primary importance and the second place in valve cavity, and when valve was positioned at primary importance, promptly during valve closing, sample chamber was by valve seal; When valve was positioned at the second place, promptly during valve opening, sample chamber was communicated with valve, and the fluid sample in the sample chamber is discharged from.More excellent, when valve was positioned at primary importance, the device that increases air pressure raise the air pressure in the sample chamber; When valve was positioned at the second place, the air pressure of rising was discharged outside the sample chamber fluid sample in the sample chamber.One preferred embodiment in, sample chamber comprises both ends open, the device of control fluid flow can seal or open the wherein opening of an end, and other end opening is used for receiving fluid sample.For example, first opening receives sample, and second opening connects valve and valve cavity, the outflow of the fluid sample in the control sample chamber.
In a preferred mode, the opening of sample chamber one end and a valve cavity communicate, and this valve cavity is used for accommodating a valve, and valve outside surface and valve cavity inwall are line contact sealing.Be bossed lines on the outside surface of valve, these lines form line with the valve cavity inwall and contact.Can certainly be, bossed lines on the outside surface of valve cavity, these lines form line with the outer surface wall of valve and contact.Like this, the sealing property between valve and the valve cavity is better, has guaranteed the sealing of sample chamber; Guaranteed also simultaneously that the sample in the sample chamber is not leaked; Special, when the air pressure in the sample chamber increased, the fluid sample in the sample chamber can not revealed away yet.Can better guarantee controllability like this to the fluid in the sample chamber.The present invention is because of existing certain air pressure, so sealing is very important in the sample chamber; Simultaneously, sample size does not make sample leak more after a little while in order to guarantee to detect effect accurately, and sealing is also extremely important.
In addition, " increasing the device of air pressure " of the present invention has the interior air pressure enlarged functional of sample chamber of the sealing of making.Specifically, can use a piston structure to realize this function, perhaps, the mode that can produce gas at the chemical reaction of sample intracavity liquid increases the air pressure in the chamber.One preferred embodiment in, use seal element sealing sample chamber and form hermetic seal, and the sample chamber internal gas pressure is increased through the motion of seal element in sample chamber with the madial wall of sample chamber.In preferred mode, seal an end opening that receives fluid sample on the sample chamber with seal element, and the device of control fluid flow can seal or open the opening of the other end on the sample chamber.Wherein, when other end opening is sealed, let the interior air pressure of sample chamber increase, when the other end was opened, the air pressure of increase forced segment fluid flow to flow out to outside the sample chamber.
In above all embodiments, this device can also comprise test chamber and testing element, and test chamber links to each other with the device of control fluid flow, and testing element is positioned at test chamber.In a preferred mode, test chamber is communicated with valve cavity, and whether the fluid in the valve control sample chamber flows in the test chamber.In the preferred mode, the air pressure that increases in the sample chamber forces segment fluid flow to flow out to the outer back of sample chamber and directly gets in the test chamber and contact with testing element.In another mode, valve cavity also is connected with the chamber of a stored samples; The air pressure that increases in the sample chamber can also force segment fluid flow to flow out to the outer back of sample chamber and directly get in the sample storage chamber.Certainly, the air pressure that is increased in the sample chamber forces the fluid that flows out to outside the sample chamber can directly get into test chamber and storage chamber simultaneously.
In other embodiments, before sample gets into sample chamber, in sample chamber, can deposit the reagent that is used to handle sample in advance.This reagent can be to be used for the solution that diluted sample or wash-out invest the sample on the ST; Certainly, these reagent also can add and fully mix with sample in the back in sample get into sample chamber.These reagent can be the buffer solution used always or the reagent or the solution of other purposes.
Certainly,, can let sample be stored in the sample chamber, wait when needing detection or needing the segment fluid flow sample, open fluid control device and flow out to outside the sample chamber by fluid sample collecting sample after sample chamber.Before opening fluid control device, can let the air pressure in the sample chamber increase earlier, the air pressure of increase forces segment fluid flow to flow to sample chamber automatically and directly tests outward or chemically examine.
In other preferred modes, this device can also comprise a lid, and lid is positioned on the sample chamber, is used to seal the opening that sample cavity one end is used for receiving sample.The juncture of lid and sample chamber is various, like snap engagement, and forced joint etc.In the embodiment, the lid inboard has the screw-in screw thread, and has the reception screw thread of supporting joint with it on the sample chamber.In another embodiment, before use, the reagent of handling sample is arranged, for example buffer solution is stored in advance in sample chamber, and lid is positioned on the sample receptive cavity, guarantees that buffer in the chamber and the sample of collecting are not subsequently leaked.
In a more excellent embodiment, lid is used with the device that increases air pressure, when lid covers the sample chamber opening, can increase the air pressure in the sample chamber simultaneously.The device that increases air pressure can be seal element, and seal element comes individualism to lid, and a jut can be set on the inwall of lid.In sample gets into sample chamber, at this moment, cover lid; Projections contact in the lid is to seal element, and along with lid engages with the opening of sample chamber, the inner projection of lid promotes seal element to the motion of sample chamber bottom; Thereby reach the compression intracavity gas, increase the effect of chamber internal gas pressure.
In another embodiment, the sealing element is attached on the lid.Seal element can link to each other with lid, and is same, and when lid engaged with the sample chamber opening, seal element also sealed the sample chamber opening thereupon and compresses the air in it.In a more excellent embodiment, seal element is positioned on the inwall of cap top, and this moment, cap top had certain thickness, to guarantee to reach certain force of compression when the pressurized air.
Sample chamber of the present invention structurally can also be carried out particular design in order to guarantee fully mixing of sample and buffer solution.As, the extruding baffle plate is set, or this sample chamber uses soft pushed material to process or the like in the chamber.In the embodiment, this sample chamber middle part is a funnel-shaped structure, and promptly this sample chamber top is bigger than lower diameter, and after the sample collection rod that is adsorbed with sample placed in the sample chamber, the absorption piece on the collection rod was positioned at the Lower Half of sample chamber.This lower chamber structure guarantees that the buffer solution in the sample chamber enough floods absorption piece fully, makes that the sample on the absorption piece can fully contact with buffer solution, thereby reaches the purpose of abundant processing sample.
The present invention also provides a kind of box simultaneously, is used to handle sample, comprises the above sample device of describing of the present invention, and box body and sample collection rod.Box body is in the same place sample chamber with the means for engaging of control fluid flow.Further, the box of this processing sample also comprises test chamber and testing element, and test chamber and testing element are positioned at box body too.When in use, the sample collection rod is used to collect testee's sample, and this sample can be solid, semisolid, liquid or gas sample.Sample collection rod after the sampling is put into sample chamber; Add buffer solution then; Re-use the device that increases air pressure and increase the sample chamber internal gas pressure, for example seal element is put into sample chamber, the air in sealing and the compression chamber perhaps directly covers the lid that has seal element.Certainly, buffer solution also can add in the sample chamber before this device uses in advance.Then, open the device of control fluid flow,, sample chamber is in communication with the outside like valve.In the embodiment, sample chamber is connected through valve cavity with test chamber, and the sample after the processing flows out sample chamber and enters into test chamber because of the gas pressure in the sample chamber, contacts with testing element, accomplishes and detects.
In some embodiments, the height of sample chamber is greater than the length of sample collection rod.Can hold whole sample collection rod.And sample chamber lower chamber height guarantees that more than or equal to the absorber element of sample collection rod absorber element is arranged in lower chamber fully.
In addition, the present invention also provides a kind of method of handling sample and sample being flowed out, and it comprises: the reagent of sample and/or processing sample is added sample chamber; Increase the air pressure in the sample chamber; Sample chamber is in communication with the outside; The air pressure that increases forces sample and/or handles sample reagent, and perhaps the mixed liquor of the two flows out to outside the sample chamber.
In a preferred mode, whether the fluid of controlling in the sample chamber through the device of control fluid flows to outside the sample chamber.In another preferred mode, sample chamber is a both ends open, and the device of control fluid is connected with an opening, and the device of increase air pressure increases air pressure through another opening.
In some embodiments, control sample chamber and extraneous being communicated with by the device of control fluid flow, such as, the baffle plate that can extract, the film that can puncture.In an embodiment, by in the valve control sample chamber with being communicated with of the external world.
In other embodiments; By the device that increases air pressure the sample chamber internal gas pressure is increased, for example: piston apparatus, perhaps; Thereby through the aqueous chemical in the sample chamber reaction gas is increased and increase air pressure etc.; One preferred embodiment in, by the gas in seal element sealing sample chamber and the compression chamber, thereby increase air pressure; This increase air pressure makes the outflow of sample mixing liquid.
In some embodiments, Buffer solution can join in the sample chamber before or after sample gets into sample chamber.
In some embodiments, can use the cotton swab of sample collection rod to collect sample, then, will put into sample chamber with the sample collection rod of sample.
In other embodiments, make the fluid engaged test element that flows out in the sample chamber, detect sample or its potpourri.Beneficial effect
The present invention makes that because of the pressure ratio ambient pressure in the sample chamber is big fluid in the chamber can flow out to outside the chamber smoothly.Special sample size more after a little while, because of the air pressure in the sample chamber, but also dependable flow and flow velocity.And then guarantee the sample size that next step detection needs, guarantee the accuracy that detects.Simultaneously, the air pressure of increase can let sample flow out outside the sample chamber fast, and the efficient of handling sample is provided, and has practiced thrift the time of accomplishing whole detection generally.The present invention also can with gathering-device, pick-up unit is bonded together, and forms sample collection, handles and detect one.This device is light and handy, conveniently transports or carries, and is particularly suitable for family and uses.
Description of drawings
Fig. 1 is the schematic perspective view of apparatus of the present invention
Fig. 2 is a valve mechanism synoptic diagram in the device
Fig. 3 is another angle valve mechanism synoptic diagram
Fig. 4 is profile valve figure
Fig. 5 is the sectional view of valve other direction
Fig. 6 is this device sample chamber cap structure exploded view
Fig. 7 is a device sample chamber cap structure decomposing section
Fig. 8 to Figure 10 has the process synoptic diagram that the lid of seal element engages with sample chamber
Figure 11 is schematic perspective view (valve is in closed condition, the primary importance of valve in valve cavity) of handling the box of sample of the present invention
Figure 12 is in the synoptic diagram (second place of valve in valve cavity) of opening at valve for box of the present invention
Figure 13 is the STRUCTURE DECOMPOSITION figure of box of the present invention
Figure 14 to Figure 17 is a box operating process synoptic diagram of the present invention
The explanation of accompanying drawing sign
Do further explanation in the face of structure or these employed technical terms of liquid-sample collection device down.
Sample
" sample " that the present invention refers to refer to needs chemical examinations whether exist with (or) analyze any material of analyte concentration; Maybe need confirm one or more samples whether exist with (or) material of the analyte of quantity, maybe need carry out the material of qualitative evaluation.Sample can be fluid sample, for example liquid sample.Liquid sample comprises body fluid, such as blood, serum, blood plasma, saliva, urine, tears, seminal fluid and marrow; Liquid sample also can be a water sample, such as seawater, river, river etc., perhaps from domestic water, municipal water use or service water resource, runoff water or sewage; Sample can be a food sample, such as milk and wine.Mucus, semisolid or solid sample can be used for making liquid, eluate, suspending liquid or leachate equal samples.For example, throat or genitals sample may be dipped in and process sample in the liquid.Sample can comprise potpourri or any relevant potpourri of liquid, solid and gas, such as the cell suspending liquid in dilution or the solution.Sample comprises biological substance, such as cell, microorganism, organelle and biochemical complexes.Liquid sample can be from producing such as solid, semisolid or high-viscosity materials such as soil, ight soil, tissue, organ, biological fluid or other occurring in nature non-liquid samples.For example, these solids or semi-solid samples can be mixed with one type of suitable solution of dilution.Sample can be macerated, freezing and thaw, perhaps other method for distilling form liquid samples.Remaining particulate material can use traditional method such as filtration or deposition to remove.
Testing element
" testing element " is any element of carrying out test.In one embodiment, testing element is a test-strips.This test-strips can comprise that the material with specificity combination that is used for immunoassay above that is right.Test-strips can be a kind of test chemical bar that after detecting completion, passes through change color or other signals variation judged results.The sample that suitable the present invention detects includes but not limited to body fluid, separated sample from biological tissue or body fluid.For example, sample can be a saliva, blood, serum, blood plasma, urine, excreta, spinal fluid, vaginal secretion, mucus and tissue.Testing element is not limited to one, can be that two or more testing elements are arranged in pick-up unit simultaneously, respectively different component in the test sample book.
The sample collection rod
The present invention also provides sample collection rod 700.In one embodiment, sample collection rod 700 has an absorber element 702 and is affectedly bashful portion 701.Absorber element 702 is processed by this area other sponge of medical grade or plastic foam material commonly used usually.But many other materials also can be made into absorber element, for example cotton or paper, perhaps other any materials with water absorbing properties.Applicator can be in advance soaked containing can stimulate in the salivary solution of tester.Thereby make and when gatherer is put into tester's mouth, collect saliva more easily.Be affectedly bashful normally rigidity of portion, help operation absorber element.The portion of being affectedly bashful can be processed by this area material commonly used, for example plastics, timber, metal or cardboard.In a preferred mode, the sample collection rod is an European patent, number EP1893740B1, the flocking property cotton swab of describing among the EP1608268B1 (flocked swab).
Embodiment
In following detailed description, the explanation of accompanying drawing and corresponding character only is a mode of explaining that by way of example the present invention can actable specific concrete scheme.We do not get rid of the present invention can also be in any other embodiment in claim scope of the present invention.
The present invention provides a kind of device of handling sample, and this device is made up of the device of sample chamber 100 and control fluid flow and the device of increase sample chamber internal gas pressure.Wherein, sample chamber 100 is connected with the device of control fluid flow.
In some embodiments, and control fluid flow device be valve 200 structures.This valve is identical with valve mechanism and function that industry is generally used, promptly when closing, connected parts is not communicated with, and after opening, is communicated with between the then coupled all or part of parts.The valve kind is various, all can be used for device of the present invention, as: revolving valve, stopcock, ball valve, needle-valve reverses valve or piston valve, gate valve, reversal valve or the like.
In a specific embodiment, like Fig. 1 and combine shown in Figure 13ly, sample chamber 100 is by the accent 101 of an end, at the bottom of the chamber 102 and the sidewall in chamber form, accent 101 is used for receiving sample.Valve cavity 206 with 102 link to each other at the bottom of the chamber, at the bottom of the chamber, have an opening 107 to communicate with valve cavity.Valve 200 is arranged in valve cavity 206, and valve 200 has the opening and closing position, is controlled by the switch on the valve 201.When valve 200 was in closed condition, when promptly valve 200 was positioned at the primary importance of valve cavity 206, to shown in Figure 16, then the opening 107 at the bottom of the sample chamber chamber was not communicated with the external world by valve 200 sealings like Figure 14; After valve 200 was opened, shown in figure 17 when promptly valve 200 is positioned at the second place of valve cavity 206,100 valves 200 through unlatching of sample chamber formed circulation with the external world.Concretely, on valve, comprise a valve passage 800, after valve 200 was opened, the fluid in the sample chamber entered into valve passage 800 through opening 107 and is discharged to outside the sample chamber 100.
In a more excellent embodiment, in order to guarantee the sealing effectiveness of valve 200, valve 200 with 102 inwall at the bottom of the valve cavity 206 sample chamber chambeies be line contact sealing.At some more specifically in the mode; The contacted outside surface 207 in the surface of contact place of valve 200 is provided with linear protrusion 203; Shown in Fig. 2 and Fig. 3, Fig. 2 is the synoptic diagram of 200 1 directions of valve, and Fig. 3 is for to rotate about 180 ° synoptic diagram at Fig. 2 valve location.Like Fig. 2, linear protrusion has 5, wherein along outside surface 2 loop wire 203d and 203e is arranged circumferentially as shown in Figure 2, with 3 perpendicular lines 203a of loop wire, 203b, and 203c (as shown in Figure 3).Valve 200 contacts with the inwall 208 of valve cavity 206 through these 5 wire projections, forms linear contact.Like this, its contact area significantly reduces than the direct contact area that forms that contacts with the inside surface of valve cavity 206 of the outside surface of valve 200, and therefore, fluid significantly reduces through the possibility that surface of contact leaks; Owing to be linear contact, face becomes line with face must rub with the face friction in addition, and friction force reduces a lot, also reduces thereby need let valve rotate used power, makes the control of valve become and operates more easily.
In addition, these 5 linear protrusion are divided into 3 parts with valve 200 outside surfaces, are respectively A faces 2071, B face 2072 and C face 2073.Aperture B hole 802 and C hole 801 are arranged respectively on B face 2072 and C face 2073, and B hole 802 is connected in valve 200 inside with C hole 801 and forms valve passage 800.In use, because of A face 2071 atresias are connected, therefore, fluid can not enter into this zone and remain in this zone, therefore, can effectively guarantee fluid outflow as much as possible, especially in sample size more after a little while, effect is more obvious.
When in use, when valve 200 was positioned at primary importance, an end opening 107 of sample chamber was by valve seal; When valve 200 is positioned at the second place; One end opening 107 of sample chamber is opened, and is connected with valve passage, and it is external that fluid sample flows to sample chamber through valve passage 800.
It is exactly to let the interior air pressure of sample chamber increase that fluid sample flows to the outer method of sample chamber, and the air pressure of increase forces fluid sample to flow out to outside the sample chamber.For example, when valve 200 was positioned at primary importance, the air pressure in the sample chamber increased, and when valve 200 was positioned at the second place, the air pressure of increase forced fluid sample to flow out to outside the sample chamber 100 through valve passage 800.In the mode embodiment below of concrete how pressure boost more detailed description is arranged.
In some embodiments; The device that increases air pressure can be the seal element 400 with sealing function, and sealing element 400 is after sample gets into sample chamber 100, from accent 101 sealing sample chamber 100; At this moment, seal element 400 contacts and forms hermetic seal with sample chamber 100 madial walls 106.Then, seal element 400 to 102 moving and air in the compression chamber at the bottom of the chamber, forms certain air pressure along accent 101.
Among the present invention, the part sample is like solid or semi-solid samples; Needs use buffer solution to dilute or neutralize, even the part sample adhesion is on sample collecting device; Need buffer solution to come wash-out or the like, therefore, in sample chamber 100, can add the Buffer solution of above-mentioned effect; Like PH buffer solution, anti-oxidant solution, or anti-adsorbent solution and protein solution or the like.These buffer solution can add before sample gets into sample chamber 100, also can get into sample chamber 100 backs at sample and add.In the specific embodiment, Buffer solution is stored in the sample chamber 100 in advance.In order to guarantee testing result more accurately, the consumption of Buffer solution can have certain requirement, and this need confirm according to sample properties and testing conditions.Generally speaking, Buffer and sample size keep certain ratio.In one embodiment, the volume ratio of Buffer solution and sample size is 1: 1.In another more concrete embodiment, the volume of Buffer solution is 1 milliliter.
In some embodiments, this device also comprises lid 500, like Fig. 1 and shown in Figure 13.One end of lid 500 and sample chamber 100 is used for receiving the opening 101 formation sealings of sample, like this, more helps Buffer solution and is pre-stored in the sample chamber 100 (when including solution).Sample chamber 100 is various with the juncture of lid 500, like plunger type, or buckle-type, or laminated type or the like, as long as after the two combined, the Buffer solution in the chamber can not leak and get final product.Among the embodiment, lid 500 inside have the screw-in screw thread, and the opening 101 of sample chamber 100 has supporting with it reception screw thread, and the two engages for screw thread.
In other embodiments, seal element 400 can be used in combination with lid 500.Among the embodiment, be designed with jut in lid 500 inside top, during use; After seal element 400 is positioned at sample chamber 100, cover lid 500, the lid inner process partly touches seal element 400; When lid 500 engages with sample chamber 100; Along with the motion of lid 500, jut promotes seal element 400 and at the bottom of the sample chamber chamber, 102 moves, thereby reaches the effect of air in the compression chamber.Among another embodiment, seal element 400 links to each other with lid 500, as, it is continuous that the two passes through thin rod, when lid 500 sealing sample chamber 100, and the air in 400 while of the seal element compression chamber 100.
In a preferred embodiment, seal element 400 and 501 supporting connections of cap top, its STRUCTURE DECOMPOSITION such as Fig. 6 and shown in Figure 7.Lid is made up of top 501 and lid 502.Cap top 501 inboards combine with lid 502 after being surrounded by seal element 400 again, form an integral body.This cap top 501 has certain height, guaranteeing after lid 500 covers sample chamber 100, to compress air in certain amount, thereby obtains certain air pressure.
Fig. 8 to Figure 10 has shown the process that increases air pressure in this lid 500 and the process that sample chamber 100 engages.As shown in Figure 8, lid 500 engages preceding state with sample chamber 100, and there is certain clearance with after cap top 501 engages in seal element 400 with the lid madial wall, and this gap is used to engage the accent 101 of sample chamber.Sectional view when Fig. 9 covers sample chamber for lid, at this moment, sample chamber 100 is covered and screws in part downwards by lid 500, and at this moment, lid is positioned at sample chamber A position, and simultaneously seal element 400 and accent 101 contact and seal up the opening 101 of sample chamber 100.Figure 10 is lid and sectional view after sample chamber combines fully, and lid 500 is positioned at sample chamber B position.At this moment, seal element 400 is with air compression in the sample chamber 100, and the A position is compressed to the gas of B position in the sample chamber, forms certain gaseous tension.
Sample processing apparatus provided by the invention can also comprise test sample chamber 300, and test chamber 300 is connected with sample chamber 100 through the device of control fluid flow, and in the embodiment, valve cavity 206 communicates with test chamber 300.Comprise testing element 301 in the test chamber 300.In one embodiment, testing element 301 is a test strips.Testing element 301 in the test chamber can be for one or more.
In the embodiment, this valve 200 is " two logical " structure, and an end of valve passage 800 leads at the bottom of the sample chamber chamber 102 and can communicate with opening 107, and the opening of the other end communicates with passage 205 and leads in the test sample chamber 300.In a mode, after sample was positioned at sample chamber 100, this moment, valve was in primary importance, and 102 opening 107 is by valve 200 sealings at the bottom of the chamber; After the sample chamber internal gas pressure is increased, open the switch 201 that is positioned on the valve, for example the switch on the changeover valve; At this moment, the B hole 802 on the valve is connected through opening 107 with sample chamber 100 and communicates, and is as shown in Figure 5; C hole 801 is connected with test chamber 300, and is as shown in Figure 4, and then sample chamber 100 is through the B hole 802 on the valve 200; C hole 801 is communicated with test chamber 300 with valve passage 800; The air pressure that sample in the chamber and the Buffer mixed liquor passage through this connection is increased forces and flow to test chamber 300, contacts with testing element 301, accomplishes and detects.
In another embodiment, this valve can be the three links structure, and an end leads at the bottom of the sample chamber chamber 102, and the other end leads to test sample chamber 300, and last end confirms that with a sample chamber or storage chamber are connected.
After sample is gathered in sample chamber; The direction of valve open has two, and opening direction guarantees that sample chamber 100 is connected with test chamber 300, and sample 102 opening 107 and passage 800 of valve 200 at the bottom of the sample chamber flow into test chamber 300; Contact with testing element 301, accomplish and detect; Another opening direction guaranteed sample chamber 100 and confirmed being communicated with of chamber, can let fluids in the sample chamber 100 flow into to be used for confirm the storage chamber that detects.Certainly, also can be that the direction that valve 200 is opened has only one; In case valve open, the fluid that from cavity 100, flows out gets in the valve passage 800, and valve passage is divided into two subchannels again; A subchannel leads to test chamber 300, transmits fluid and contacts to test chamber and with testing element 301; Another subchannel leads in the storage chamber, transmits fluid and in storage chamber, uses to confirming to detect usefulness.
The present invention also provides a kind of box simultaneously, is used for the preceding sample of processing and detecting, comprises sample processing apparatus and sample collection rod 700.Sample collection rod 700 is made up of hand part 701 and absorber element 702.Absorber element 702 can be processed by the material with absorption property, like cotton swab, and sponge or the like, this absorber element 702 can adsorb solid, semisolid, liquid even gas sample.In the preferred embodiment, the absorber element 702 on this sample collection rod is a cotton swab, and the sample of collection is a saliva.
In some preferred embodiments,, particularly under the less situation of sample collection amount, can design the sample chamber 100 of special structure in order better the sample of sample collection in sample chamber 100 and in sample chamber to be mixed with Buffer solution.For example, dividing plate with holes is set in sample chamber 100, the absorption piece 702 of sample collection rod 700 can fully be discharged sample wherein through the dividing plate extruding; Perhaps, a neck portion is set on sample chamber 100, absorption piece 702 obtains extruding in neck; Discharge sample; Again perhaps, change the material of sample chamber 100 into the resiliency compressible material, after absorption piece 702 gets into sample chamber 100; Extruding sample chamber 100, thus discharge sample and sample is fully mixed with Buffer solution.In a preferred embodiment, sample chamber 100 upper cavities 103 are bigger than lower chamber 104 diameters, and the middle part is funnel-shaped structure, and is as shown in Figure 1.In the more preferred mode; Lower chamber 104 is highly for can and guaranteeing that the enough complete foams of Buffer solution in the sample chamber 100 cross cotton swab 702 with cotton swab 702 height such as grade of collecting rod; Like this can be so that the sample on the cotton swab 702 can fully contact with Buffer solution, Buffer solution is eluted sample and mix each other with sample fully.
In one embodiment; Seal element 400 is positioned on the sample collection rod 700; After sample collection rod 700 had been gathered sample, when putting into sample chamber 100, seal element 400 on it got into sample chamber 100 and simultaneously with its sealing; Along with collecting rod 700 at the bottom of the sample chamber chamber during 102 motions, thus seal element 400 air in 102 motion compression samples chambeies at the bottom of the chamber thereupon.Sealing element 400 can be " O " type circle, should be positioned on the sample collection rod 700 by " O " type circle, apart from absorber element 702 and the excellent top of collection certain distance is arranged all.
Like Figure 11 and shown in Figure 12, in the specific embodiment, box body 600 is with sample chamber 100, and valve 200 and test chamber 300 engage with testing element 301 and be one, and Figure 13 is its STRUCTURE DECOMPOSITION figure.Box body is made up of upper cartridge body 601 and lower box body 602, and sample chamber 100 is positioned at the box body 600 that upper and lower box body forms with test chamber 300, and testing element 301 is positioned at test chamber 300.Box body 600 has a window 307 in the corresponding position, results display area territory of testing element 301, and this window can be transparent, is used to observe testing result.In the specific embodiments, testing element 301 is a test strips, and the sample uptake zone 3011 of this test strips is connected with valve 200.Specifically, like Figure 14, a passage 205 is provided, this passage one end connects test chamber 300, and the other end connects valve cavity 206; Valve cavity 206 again with 102 be communicated with sample chamber at the bottom of the sample chamber chamber through opening 107, whether the 200 control test chambers 300 of the valve in valve cavity 206 are communicated with fluid between the sample chamber 100 simultaneously.Have switchgear 201 on the valve 200, be used for the opening and closing of by-pass valve control 200, promptly control the circulation of sample chamber 100 and test chamber 300.The opening 101 of an end has lid 500 sealing sample chamber on the sample chamber 100, and this cap top 501 is connected with seal element 400.The box of this sample process before use; Valve 200 is in closed condition; The valve switch position is shown in figure 11; At this moment, the B hole 802 of valve 200 interior valve passage 800 1 ends is positioned at test chamber 300 junctions and communicates with test chamber, and the C hole 801 of the valve passage 800 other ends then inwall 208 of valve cavity 206 engages; Valve passage 800 is not communicated with sample chamber 100 and test chamber 300, and the other end opening 107 of sample chamber 100 is by surface 207 sealings of valve 200.Being used to cushion Buffer solution with eluted sample is pre-existing in the sample chamber 100 and by lid 500 and seals.
When in use, 700 contact persons under inspection take a sample with the sample collection rod, for example put into and get saliva sample in the mouth; Then; Shown in figure 14, open the lid 500 of sample chamber 100, shown in figure 15 again; To be inserted in the sample chamber 100 with the sample collection of sample rod 700, and make the cotton swab 702 of collecting rod arrive at the bottom of the sample chamber chambeies 102 to guarantee that Buffer solution foam crosses the cotton swab 702 on the sample collection rod.Get into the state of sample chamber 100 in order to observe sample collection rod 700, can on box body 600, transparent watch window 108 be set sample chamber lower chamber 104 corresponding positions.Then, shown in figure 16, cover lid 500 also makes supporting joint of screw thread on lid 500 and the sample chamber 100, at this moment, is positioned at seal element 400 sealings of lid and the air in compression samples chamber 100, forms certain air pressure.In order sample fully to be mixed with Buffer solution and to react, box body 600 is rocked 10 seconds after, again box body 600 was left standstill 2 minutes.Then, shown in figure 17, open valve 200, switch 201 positions on the valve are shown in figure 12 at this moment.At this moment; Through the rotation of switch, an end opening of the passage in the valve 200 or hole 802 go to 102 outlets, 107 places at the bottom of the sample chamber chamber, are communicated with sample chamber; 801 holes then go to original place, 802 hole sites; Promptly communicate with the inlet or the passage 205 of test chamber 300, like this, C hole 801 is communicated with test sample chamber 300.After then sample chamber 100 and test chamber 300 passage 800 through valve 200 is communicated with; Sample mixing liquid in the sample chamber 100 is because of the gas pressure in the chamber; Force segment fluid flow to flow into test chamber 300 and contact with the uptake zone 3011 of test strips 301 along valve 200, test strips is tested.
Identical in order to guarantee the air pressure that in sample cavity 100, produces; The distance that can let lid 500 on the opening 101 of cavity 100, move is identical; Let the air pressure that produced in the sample chamber in each different device identical like this; Thereby force the external volume of the interior fluid exhaust chamber of cavity also identical, the performance homogeneous of assurance device is with stable.For example can be provided with in the lid with opening 101 on the number and the degree of depth of screw thread, can also control the displacement of lid 500 at raised structures 109 of the accent place of cavity 100 101 arranged outside at sample chamber accent 101 places.
When sample is a solid or semisolid the time, sample has suspension and is present in the mixed liquor with after Buffer solution mixes.In order to guarantee the accuracy of pattern detection, can a filtration unit 302 be set between valve 200 and test chamber 300, be used for filtering out the suspension in the mixed liquor, like filter paper, filter or the like.For example let and apply on the position 3011 through the sample that filter pad 302 flows to testing element from the fluid of passage 205.
Claims (28)
1. device comprises:
Sample chamber;
The device of control fluid flow;
Sample chamber is connected with the device of control fluid flow;
Increase the device of air pressure, be used to increase the air pressure in the sample chamber.
2. device as claimed in claim 1 is characterized in that, the air pressure of the increase in the sample chamber forces fluid sample to flow out to outside the sample chamber.
3. device as claimed in claim 1 is characterized in that, the device of control fluid flow has the primary importance and the second place, and when it was positioned at primary importance, sample chamber did not communicate with the external world; When it was positioned at the second place, the air pressure that increases in the sample chamber forced fluid sample to flow out to outside the sample chamber.
4. device as claimed in claim 1 is characterized in that sample chamber comprises first and second openings, and wherein first opening is used for receiving sample; Second opening is connected with the device of control fluid flow.
5. device as claimed in claim 4 is characterized in that, the device that increases air pressure is used for engaging first opening of sample chamber.
6. device as claimed in claim 4 is characterized in that, the device of control fluid flow comprises valve and the valve cavity that holds valve, and wherein second opening of sample chamber communicates with valve cavity.
7. device as claimed in claim 6 is characterized in that, valve outside surface and valve cavity inner wall surface are line contact sealing.
8. device as claimed in claim 6 is characterized in that, valve has the primary importance and the second place of opening sample chamber second opening of sealing sample chamber second opening in valve cavity.
9. device as claimed in claim 8 is characterized in that, when valve was positioned at primary importance, the air pressure in the sample chamber increased; When valve was positioned at the second place, the air pressure of increase forced fluid sample to pass through the outflow of second opening.
10. device as claimed in claim 9, the fluid sample that flows out through sample chamber second opening enters into a test chamber.
11. device as claimed in claim 1, this device also comprise a test chamber, whether the fluid sample in the device control sample chamber of control fluid flow enters into test chamber.
12. device as claimed in claim 1, this device comprise that also is used to confirm a samples tested storage chamber, whether the fluid sample in the device control sample chamber of control fluid flow enters into storage chamber.
13., it is characterized in that the device that increases air pressure is a seal element like claim 1 or 5 described devices.
14. device as claimed in claim 13 is characterized in that, seal element and sample chamber madial wall form hermetic seal.
15. device as claimed in claim 14 is characterized in that, this device also comprises a lid, has the sealing element on the lid.
16. device as claimed in claim 1 is characterized in that, comprises the reagent of handling sample in the sample chamber, wherein reagent is buffer solution.
17. device as claimed in claim 1 is characterized in that, sample chamber is funnel shaped structure.
18. device as claimed in claim 1 is characterized in that, said sample is a saliva.
19. a box comprises: device as claimed in claim 1, and sample collection rod.
20. box as claimed in claim 19 is characterized in that, said sample collection rod comprises the cotton swab that is used to gather sample.
21. box as claimed in claim 19 is characterized in that, the device that increases air pressure is a seal element, and the sealing element is positioned on the sample collection rod.
22. a method of handling sample comprises:
The reagent of sample and/or processing sample is added in the sample chamber;
Increase the air pressure in the sample chamber;
Sample chamber is in communication with the outside;
The air pressure that increases forces fluid sample to flow out outside the sample chamber.
23. method as claimed in claim 22 is characterized in that, controls with extraneous being communicated with by valve in the sample chamber.
24. method as claimed in claim 23 is characterized in that, when letting valve be in primary importance, increases the air pressure in the sample chamber; When letting valve be in the second place, the air pressure of increase forces fluid sample to flow out to outside the sample chamber through valve.
25. method as claimed in claim 22 is characterized in that, the reagent of handling sample can join in the sample chamber before or after sample gets into sample chamber.
26. method as claimed in claim 22 is characterized in that, lets seal element sealing and compression samples chamber increase the air pressure in the sample chamber.
27. method as claimed in claim 22 is characterized in that, will put into sample chamber with the sample collection rod of sample, increases the air pressure in the sample chamber then.
28. method as claimed in claim 22 is characterized in that, makes the fluid sample engaged test element that flows out in the sample chamber.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510511762.2A CN105115798B (en) | 2010-11-09 | 2010-11-09 | A kind of method for handling sample |
| CN201010538076.1A CN102466581B (en) | 2010-11-09 | 2010-11-09 | A kind of device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010538076.1A CN102466581B (en) | 2010-11-09 | 2010-11-09 | A kind of device |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510511762.2A Division CN105115798B (en) | 2010-11-09 | 2010-11-09 | A kind of method for handling sample |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102466581A true CN102466581A (en) | 2012-05-23 |
| CN102466581B CN102466581B (en) | 2015-09-30 |
Family
ID=46070485
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510511762.2A Expired - Fee Related CN105115798B (en) | 2010-11-09 | 2010-11-09 | A kind of method for handling sample |
| CN201010538076.1A Expired - Fee Related CN102466581B (en) | 2010-11-09 | 2010-11-09 | A kind of device |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510511762.2A Expired - Fee Related CN105115798B (en) | 2010-11-09 | 2010-11-09 | A kind of method for handling sample |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN105115798B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014015752A1 (en) * | 2012-07-23 | 2014-01-30 | Abon Biohparm (Hangzhou) Co., Ltd | Specimen processing device |
| CN103776660A (en) * | 2012-10-24 | 2014-05-07 | 艾博生物医药(杭州)有限公司 | Device |
| CN104634611A (en) * | 2013-11-14 | 2015-05-20 | 艾博生物医药(杭州)有限公司 | Device and method using same |
| CN106323949A (en) * | 2015-07-01 | 2017-01-11 | 宏达国际电子股份有限公司 | Test apparatus and pressurizing assembly thereof |
| CN112697552A (en) * | 2020-12-09 | 2021-04-23 | 湖南泰贵生物科技有限公司 | Smear device for clinical examination |
| CN114151546A (en) * | 2021-11-19 | 2022-03-08 | 奥星制药设备（石家庄）有限公司 | Flour mill |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0508010A1 (en) * | 1991-04-10 | 1992-10-14 | La Mina Ltd. | Biological fluids testing membrane module and method of conducting same |
| CN1509409A (en) * | 2001-05-18 | 2004-06-30 | ����ʵ�鼼����˾ | In-line test device and methods of use |
| US20070088252A1 (en) * | 2005-10-19 | 2007-04-19 | Cd Solutions, Llc | Apparatus and method for mixing and transferring medications |
| US7341669B2 (en) * | 2002-10-11 | 2008-03-11 | G6 Science Corp. | Filter methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses |
| WO2009139632A1 (en) * | 2008-05-14 | 2009-11-19 | Medavinci Development B.V. | Device and method for separating and analyzing blood |
| CN201596509U (en) * | 2006-03-29 | 2010-10-06 | 因弗因斯医药瑞士股份有限公司 | Analysis device |
| CN201607358U (en) * | 2009-12-11 | 2010-10-13 | 上海快德行生物技术有限公司 | Mixing device of medical testing sample |
| CN202119661U (en) * | 2010-11-09 | 2012-01-18 | 艾博生物医药(杭州)有限公司 | Device and box for treating samples |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4202561A1 (en) * | 1992-01-30 | 1993-08-05 | Boehringer Mannheim Gmbh | DEVICE FOR DELIVERING AN ANALYZING LIQUID |
| US7501283B2 (en) * | 2003-08-11 | 2009-03-10 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
| US7767152B2 (en) * | 2003-08-11 | 2010-08-03 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction retaining tray, and method of operation |
| EP1829613B1 (en) * | 2006-03-02 | 2022-03-30 | Nexus Biosystems, Inc. | Storage unit and transfer system for storing and providing biological samples |
| CN101835538B (en) * | 2007-10-23 | 2013-09-04 | 贝克顿·迪金森公司 | Closed kit for tissue containment and stabilization for molecular and histopathology diagnostics |
-
2010
- 2010-11-09 CN CN201510511762.2A patent/CN105115798B/en not_active Expired - Fee Related
- 2010-11-09 CN CN201010538076.1A patent/CN102466581B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0508010A1 (en) * | 1991-04-10 | 1992-10-14 | La Mina Ltd. | Biological fluids testing membrane module and method of conducting same |
| CN1509409A (en) * | 2001-05-18 | 2004-06-30 | ����ʵ�鼼����˾ | In-line test device and methods of use |
| US7341669B2 (en) * | 2002-10-11 | 2008-03-11 | G6 Science Corp. | Filter methods to capture a desired amount of material from a sample suspension for monolayer deposition, analysis or other uses |
| US20070088252A1 (en) * | 2005-10-19 | 2007-04-19 | Cd Solutions, Llc | Apparatus and method for mixing and transferring medications |
| CN201596509U (en) * | 2006-03-29 | 2010-10-06 | 因弗因斯医药瑞士股份有限公司 | Analysis device |
| WO2009139632A1 (en) * | 2008-05-14 | 2009-11-19 | Medavinci Development B.V. | Device and method for separating and analyzing blood |
| CN201607358U (en) * | 2009-12-11 | 2010-10-13 | 上海快德行生物技术有限公司 | Mixing device of medical testing sample |
| CN202119661U (en) * | 2010-11-09 | 2012-01-18 | 艾博生物医药(杭州)有限公司 | Device and box for treating samples |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014015752A1 (en) * | 2012-07-23 | 2014-01-30 | Abon Biohparm (Hangzhou) Co., Ltd | Specimen processing device |
| CN103575575A (en) * | 2012-07-23 | 2014-02-12 | 艾博生物医药(杭州)有限公司 | Device |
| CN103776660A (en) * | 2012-10-24 | 2014-05-07 | 艾博生物医药(杭州)有限公司 | Device |
| CN103776660B (en) * | 2012-10-24 | 2016-03-09 | 艾博生物医药(杭州)有限公司 | A kind of device |
| CN104634611A (en) * | 2013-11-14 | 2015-05-20 | 艾博生物医药(杭州)有限公司 | Device and method using same |
| CN104634611B (en) * | 2013-11-14 | 2018-07-13 | 艾博生物医药(杭州)有限公司 | A method of the device of quantitative shunting is carried out to liquid sample and uses the device |
| US9995743B2 (en) | 2015-07-01 | 2018-06-12 | Htc Corporation | Test apparatus and pressurizing assembly thereof |
| CN106323949A (en) * | 2015-07-01 | 2017-01-11 | 宏达国际电子股份有限公司 | Test apparatus and pressurizing assembly thereof |
| CN106323949B (en) * | 2015-07-01 | 2019-05-24 | 宏达国际电子股份有限公司 | Detection device and its pressure-applying unit |
| CN112697552A (en) * | 2020-12-09 | 2021-04-23 | 湖南泰贵生物科技有限公司 | Smear device for clinical examination |
| CN112697552B (en) * | 2020-12-09 | 2023-02-17 | 青岛市妇女儿童医院 | Smear device for clinical examination |
| CN114151546A (en) * | 2021-11-19 | 2022-03-08 | 奥星制药设备（石家庄）有限公司 | Flour mill |
| CN114151546B (en) * | 2021-11-19 | 2024-01-05 | 奥星制药设备（石家庄）有限公司 | Flour mill |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105115798A (en) | 2015-12-02 |
| CN102466581B (en) | 2015-09-30 |
| CN105115798B (en) | 2018-02-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110161266B (en) | Method for collecting liquid sample | |
| WO2017156869A1 (en) | Sample measurement device, and sample collection and measurement device and method | |
| CN102466581A (en) | Device | |
| CN103776660B (en) | A kind of device | |
| CN112034150B (en) | Sample collection and detection device and method | |
| CN212410604U (en) | Detection device | |
| CN110477957B (en) | Sample collecting and detecting device | |
| CN210774757U (en) | Sampling and detecting integrated device | |
| CN203083845U (en) | Collecting device | |
| CN100466988C (en) | Biological specimen collection and analysis system | |
| CN102379724A (en) | Device for collecting fluid samples | |
| CN205720234U (en) | A kind of collection and detection device of sample | |
| CN202119661U (en) | Device and box for treating samples | |
| CN103575575A (en) | Device | |
| CN202141619U (en) | Sample processing device and box employing same | |
| CN106289933B (en) | Cover body and device for storing and mixing solid and liquid | |
| CN208140386U (en) | Fecal sample integral collecting device | |
| CN110477958B (en) | Method for collecting and detecting sample | |
| CN202928839U (en) | Sample collection device | |
| CN105716905B (en) | A kind of sample collection detection method | |
| CN201974305U (en) | Device for collecting and detecting samples | |
| CN210401425U (en) | Sample collecting and detecting device | |
| CN210401424U (en) | Sample collection member | |
| CN105748108B (en) | A kind of device | |
| CN102589929A (en) | Sample collecting and detecting device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150930 Termination date: 20211109 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |