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CN102302678A - Skin membrane repair drug - Google Patents

Skin membrane repair drug Download PDF

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Publication number
CN102302678A
CN102302678A CN201110273557A CN201110273557A CN102302678A CN 102302678 A CN102302678 A CN 102302678A CN 201110273557 A CN201110273557 A CN 201110273557A CN 201110273557 A CN201110273557 A CN 201110273557A CN 102302678 A CN102302678 A CN 102302678A
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kilograms
drug
parts
skin
membrane repair
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CN201110273557A
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CN102302678B (en
Inventor
章腾明
何大明
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Yunnan Yuncaotang Cosmetics Co Ltd
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Abstract

The invention provides a skin membrane repair drug. The skin membrane repair drug is characterized by comprising the following bulk drugs in parts by mass: 10-20 parts of rhizoma coptidis, 5-10 parts of dragon's blood, 10-20 parts of pearl powder, 10-20 parts of bletilla striata, 5-10 parts of dahurian angelica, 25-35 parts of lithospermum and 5-15 parts of safflower. The skin membrane repair drug has the beneficial effects that compatibility between the drug and body tissues is improved, the drug can be fully absorbed by skin and the filled drug is turned into one part of the incomplete tissues, and thus efficacies of purging pathogenic fire, clearing away toxic materials, eliminating dampness, promoting blood circulation, cooling blood, stopping bleeding, relieving pain, removing blood stasis, discharging pus, resisting bacteria and diminishing inflammation, promoting tissue regeneration and the like can be fully exerted, wound healing is promoted and skin grafting procedure is omitted and no or less scars are left. The skin membrane repair drug is applicable to skin membrane repair for burn and scald wounds as well as chronic rhinitis, solar dermatitis, cheilosis, infant red buttock and the like; and the skin membrane repair drug can achieve immediate curing effect after use.

Description

A kind of epithelium is repaired medicine
 
Technical field
The present invention relates to a kind of medicine for external use, especially a kind of pure Chinese medicine medicine for external use of repairing the damage epithelium belongs to medical science medicine technical field.
Background technology
Burn be the high temperature that causes by the multiple reason in outside to the damage that skin, muscle cause, be commonly referred to pyretic toxicity and soak wound.In treatment during burn, modern doctor trained in Western medicine use more antibiotic to prevent its traumatic infection threat to life, and to wound or wound surface clean, the processing of downright bad muscular tissue, rigorous disinfecting; Wrapping afterwards also needs during the treatment regularly regularly to change dressings, and wound or wound surface are used any medicine hardly; Only let its self-sow, reparation, but this method in fact effect is unsatisfactory, especially when skin is inflicted heavy losses on and is injured corium, Musclar layer; Generally be difficult to repair former state; Can only repair through the scar tissue that connective tissue forms, not only leave over cicatrix, even also will carry out skin grafting; Thereby bring very big misery to the patient, and medical expense is extremely expensive.
The traditional Chinese medical science of China then is essentially different with doctor trained in Western medicine, and the Chinese traditional treatment burn is to be used for bringing into play its drug effect with natural drug outer, is main with heat clearing away, detoxifcation, dampness, convergence, hemostasis, pain relieving; Promptly wound surface is left intact, after only blister being discharged water, medicine-feeding immediately; Pain relieving at once alleviates the pain of injury, fully stimulates the regeneration capacity of human body cell through external used medicine; Impel muscular tissue growth fast again, thereby reach the therapeutic effect of short-term recovery from illness.But because the difference and the human body difference of every kind of medicine ingredient cause its therapeutic effect to a lot of patients also not fully up to expectations, be difficult to quickly alleviating pain, healing rate is slow, stays cicatrix etc. after healing.
Summary of the invention
The object of the present invention is to provide a kind of can fast Absorption, and can rebuild wound tissue, rebuild blood vessel blood fortune; Promote cell regeneration, it is long to promote newly to granulate again, and recovers mucosa; Damaged skin progressively is grown on the mucosa, thereby accomplishes the medicine for external use that epithelium is repaired.
The present invention is to provide a kind of like this epithelium and repair medicine, it is characterized in that forming by the crude drug of following mass parts:
Rhizoma Coptidis 10-20 Sanguis Draxonis 5-10
Margarita powder 10-20 Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20
Radix Angelicae Dahuricae 5-10 Radix Arnebiae (Radix Lithospermi) 25-35
Flos Carthami 5-15
Wherein, Rhizoma Coptidis is a monarch drug, ability pathogenic fire purging, detoxifcation, dampness, anti-inflammation; Margarita powder, the Pseudobulbus Bletillae (Rhizoma Bletillae) are ministerial drug, can granulation promoting put on flesh, and promote wound healing; Flos Carthami, Sanguis Draxonis are adjuvant drug, can invigorate blood circulation, dissipating blood stasis, granulation promoting, hemostasis, antifungal; The Radix Angelicae Dahuricae is a messenger drug, can analgesic therapy, eliminating stagnation, evacuation of pus, and Radix Arnebiae (Radix Lithospermi) can removing heat from blood, invigorate blood circulation, heat clearing away, detoxifcation.
Epithelium provided by the invention is repaired medicine and is prepared through following method:
A, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Flos Carthami, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi) are ground, mix, in compound, add mass concentration and be 75% medical alcohol to not having the mix material, flood after 24 hours, mistake filters filtrating;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, flood the identical time after, cross and filter filtrating;
The filtrating of C, combining step A, B is put into filtrating to dissolving with Sanguis Draxonis, put into Margarita powder after, reclaim ethanol, fluid extract, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, epithelium is repaired powder;
D, step C gained epithelium is repaired powder admix in the Oleum Radix Arnebiae (Oleum Radix Lithospermi), promptly get the epithelium repairing paste to mastic.
The following method acquisition of said Oleum Radix Arnebiae (Oleum Radix Lithospermi) process: with after the Radix Arnebiae (Radix Lithospermi) sterilization, add the edible vegetable oil of 6 times of mass parts earlier, soaked 24~46 hours, filtration gets Oleum Radix Arnebiae (Oleum Radix Lithospermi).
Method for using:
For moist wound: sprinkle epithelium and repair powder, can prevent to ooze out, play the effect of antiinflammatory, hemostasis, granulation promoting, skin.
For the dryness wound: be coated with the epithelial membrane repairing paste, can soften the skin crust, repair as early as possible, do not stay or stay less cicatrix.
To dark II 0Burn: after using the present invention's epithelium reparation medicine (look concrete condition and use epithelium to repair powder or cream separately, perhaps unite and use epithelium to repair powder and cream), in three weeks, can recover, need not make skin graft, and preventing from scar.
Minor details are referred to the toe gangrene: after using the present invention's epithelium reparation medicine (look concrete condition and use epithelium to repair powder or cream separately, perhaps unite and use epithelium to repair powder and cream), can play controlling inflammation, promote the effect of regrowth.
Damaged and can not stitching person to bulk skin and flesh due to the huge wound: as after using the present invention's epithelium to repair medicine (look concrete condition and use epithelium to repair powder or cream separately, perhaps unite and use epithelium to repair powder and cream), can to play the effect that promotes regrowth.
The present invention has advantage and effect: adopt such scheme, the compatibility that can improve medicine and body tissue promotes that skin can absorb the drug fully, and becomes the part of incomplete tissue after medicine is filled, and gives full play to the pathogenic fire purging of medicine; Detoxifcation, dampness is invigorated blood circulation, removing heat from blood, hemostasis; Analgesic therapy, dissipating blood stasis, evacuation of pus, anti-inflammation; Granulation promoting effect such as put on flesh promotes wound healing, need not make skin graft, and does not stay or stay less cicatrix; Be not only applicable to the epithelium reparation of burn wound surface, chronic rhinitis, solar dermatitis, cheilosis, infant diaper dermatitis etc. also are suitable for, and after using the present invention's epithelium reparation medicine, instant therapeutic effect of healing is arranged.
The specific embodiment
Below in conjunction with embodiment the present invention is done and to further describe.
Embodiment 1
Get the raw materials ready by following prescription:
10 kilograms of 10 kilograms of Sanguis Draxonis of Rhizoma Coptidis
20 kilograms of 10 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita powder
35 kilograms of 5 kilograms of Radix Arnebiae (Radix Lithospermi)s of the Radix Angelicae Dahuricae
10 kilograms on Flos Carthami
Prepare through following method:
A, 10 kilograms of Rhizoma Coptidis, 5 kilograms of Radixs Angelicae Dahuricae, 10 kilograms of Flos Carthamis, 20 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 35 kilograms of Radix Arnebiae (Radix Lithospermi)s are ground, mix after, in compound, add mass concentration and be 75% medical alcohol to not having the mix material, flood after 24 hours, mistake filters filtrating;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, flood the identical time after, cross and filter filtrating;
The filtrating of C, combining step A, B is put into filtrating to dissolving with 10 kilograms of Sanguis Draxonis, put into 10 kilograms of Margarita powder after, reclaim ethanol by routine, fluid extract, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, epithelium is repaired powder.
Embodiment 2
Get the raw materials ready by following prescription:
5 kilograms of 20 kilograms of Sanguis Draxonis of Rhizoma Coptidis
10 kilograms of 20 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita powder
20 kilograms of 10 kilograms of Radix Arnebiae (Radix Lithospermi)s of the Radix Angelicae Dahuricae
15 kilograms on Flos Carthami
Prepare through following method:
A, 20 kilograms of Rhizoma Coptidis, 10 kilograms of Radixs Angelicae Dahuricae, 15 kilograms of Flos Carthamis, 10 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 kilograms of Radix Arnebiae (Radix Lithospermi)s are ground, mix after, in compound, add mass concentration and be 75% medical alcohol to not having the mix material, flood after 24 hours, mistake filters filtrating;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, flood the identical time after, cross and filter filtrating;
The filtrating of C, combining step A, B is put into filtrating to dissolving with 5 kilograms of Sanguis Draxonis, put into 20 kilograms of Margarita powder after, reclaim ethanol by routine, fluid extract, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, epithelium is repaired powder.
Embodiment 3
Get the raw materials ready by following prescription:
10 kilograms of 13 kilograms of Sanguis Draxonis of Rhizoma Coptidis
15 kilograms of 15 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita powder
35 kilograms of 6 kilograms of Radix Arnebiae (Radix Lithospermi)s of the Radix Angelicae Dahuricae
6 kilograms on Flos Carthami
Prepare through following method:
A, 13 kilograms of Rhizoma Coptidis, 6 kilograms of Radixs Angelicae Dahuricae, 6 kilograms of Flos Carthamis, 15 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 35 kilograms of Radix Arnebiae (Radix Lithospermi)s are ground, mix after, in compound, add mass concentration and be 75% medical alcohol to not having the mix material, flood after 24 hours, mistake filters filtrating;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, flood the identical time after, cross and filter filtrating;
The filtrating of C, combining step A, B is put into filtrating to dissolving with 10 kilograms of Sanguis Draxonis, put into 15 kilograms of Margarita powder after, reclaim ethanol by routine, fluid extract, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, epithelium is repaired powder.
Embodiment 4
Get the raw materials ready by following prescription:
10 kilograms of 15 kilograms of Sanguis Draxonis of Rhizoma Coptidis
12 kilograms of 15 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita powder
25 kilograms of 8 kilograms of Radix Arnebiae (Radix Lithospermi)s of the Radix Angelicae Dahuricae
15 kilograms on Flos Carthami
Prepare through following method:
A, 15 kilograms of Rhizoma Coptidis, 8 kilograms of Radixs Angelicae Dahuricae, 15 kilograms of Flos Carthamis, 12 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 kilograms of Radix Arnebiae (Radix Lithospermi)s are ground, mix after, in compound, add mass concentration and be 75% medical alcohol to not having the mix material, flood after 24 hours, mistake filters filtrating;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, flood the identical time after, cross and filter filtrating;
The filtrating of C, combining step A, B is put into filtrating to dissolving with 10 kilograms of Sanguis Draxonis, put into 15 kilograms of Margarita powder after, reclaim ethanol by routine, fluid extract, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, epithelium is repaired powder;
D, step C gained epithelium is repaired powder admix in the Oleum Radix Arnebiae (Oleum Radix Lithospermi), promptly get the epithelium repairing paste.
The following method of said Oleum Radix Arnebiae (Oleum Radix Lithospermi) process obtains: with after 10 kilograms of Radix Arnebiae (Radix Lithospermi)s sterilizations, add 60 kilograms of edible vegetable oils earlier, soaked 24 hours, filter, get Oleum Radix Arnebiae (Oleum Radix Lithospermi).
Rhizoma Coptidis 10-20 Sanguis Draxonis 5-10
Margarita powder 10-20 Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20
Radix Angelicae Dahuricae 5-10 Radix Arnebiae (Radix Lithospermi) 25-35
Flos Carthami 5-15
Embodiment 5
Get the raw materials ready by following prescription:
8 kilograms of 10 kilograms of Sanguis Draxonis of Rhizoma Coptidis
15 kilograms of 17 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s of Margarita powder
30 kilograms of 10 kilograms of Radix Arnebiae (Radix Lithospermi)s of the Radix Angelicae Dahuricae
10 kilograms on Flos Carthami
Prepare through following method:
A, 10 kilograms of Rhizoma Coptidis, 10 kilograms of Radixs Angelicae Dahuricae, 10 kilograms of Flos Carthamis, 15 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 kilograms of Radix Arnebiae (Radix Lithospermi)s are ground, mix after, in compound, add mass concentration and be 75% medical alcohol to not having the mix material, flood after 24 hours, mistake filters filtrating;
B, filtering residue continue to use the medical alcohol with steps A same concentrations, same amount, flood the identical time after, cross and filter filtrating;
The filtrating of C, combining step A, B is put into filtrating to dissolving with 8 kilograms of Sanguis Draxonis, put into 17 kilograms of Margarita powder after, reclaim ethanol by routine, fluid extract, through high temperature sterilization, low-temperature bake is ground into 300 order fine powders, epithelium is repaired powder;
D, step C gained epithelium is repaired powder admix in the Oleum Radix Arnebiae (Oleum Radix Lithospermi), promptly get the epithelium repairing paste.
The following method of said Oleum Radix Arnebiae (Oleum Radix Lithospermi) process obtains: with after 10 kilograms of Radix Arnebiae (Radix Lithospermi)s sterilizations, add 60 kilograms of edible vegetable oils earlier, soaked 24 hours, filter, get Oleum Radix Arnebiae (Oleum Radix Lithospermi).
For showing the present invention's effect, prove through clinical trial below.
One, data and method
1, physical data
The burn patient is totally 120 examples, and 50 examples of wherein burning are scalded 70 examples, occur skin bulla, edema in various degree, even burned black, are diagnosed as dark II through hospital 0, wound reaches corium and muscle.120 examples are divided into matched group and treatment is organized two groups at random, and two groups of case ordinary circumstances are seen table 1.
2, Therapeutic Method
Matched group uses commercial burn, soup to hinder cream, a twice-daily, sooner or later respectively once.
The treatment group uses the epithelium of the embodiment of the invention 3,4 to repair medicated powder and ointment, a twice-daily, sooner or later respectively once.
Two groups are all used all around by the identical course of treatment, and during treating, stop using other medicines.
3, observational technique
Observe once weekly during the medication, comprise the doing well,improving situation, untoward reaction.Treatment finished in two weeks, by special messenger's check, observed skin and improved situation.
Two, curative effect judgment criteria
1, criterion of therapeutical effect
According to the criterion of therapeutical effect of Ministry of Public Health bureau of drug administration about " the clinical research guideline of new drug (Chinese medicine) treatment burn and skin ".
Cure: wound healing, skin recovers normal function, and cicatrix is few and little;
Produce effects: wound healing, skin recovers basic function, and cicatrix is arranged;
Effectively: wound healing, the skin functional rehabilitation is incomplete, and cicatrix is arranged;
Invalid: wound healing, but the skin function do not recover, and cicatrix is big.
2, statistical method
Enumeration data adopts X 2The t check is adopted in check, measurement data.
Total effective rate=cure rate+obvious effective rate+effective percentage
Three, result
1, burn improvement situation is seen table 2.
2, scald the improvement situation and see table 3.
3, untoward reaction
Treatment group patient and matched group patient all have no adverse reaction.
In addition, the present invention also has following effect:
A, wound 26 people, totally 42 refer to, and wherein: the minor details cutting is hindered 12 and is referred to that weight wounds 14 and refers to from disconnected fully, and backing is hindered 13 and referred to, sawmilling is hindered 3 and referred to, wherein beyond the first camber line, keeps distal joint fully from breaking, and the fingernail finger tip all grows after the medication; Though backing, weight wound, finger distortion is entirely hindered in sawmilling, badly mutilated, the joint is broken, and phalanges ruptures but still the retainer, behind the epithelium reparation powder of the use embodiment of the invention 1, in 2 months, recover former state, and function is normal, effective percentage 100%.
B, bulk skin and flesh avulsion 20 examples, male 12 people, women 8 people, wound is big; Appear humerus, two Femur blood vessels spray blood, hospitalize needs the pectoralis major flap valve to transplant; But patient's refusal, behind the epithelium reparation medicated powder and ointment treatment with the embodiment of the invention 2 and 5,20 routine patients all cure; Only stay a little cicatrix, the hands functional rehabilitation is good, effective percentage 100%.
C, traffic accident 22 examples are the male, and the bulk skin and flesh disappearance that has reaches 20cm * 10cm * 1cm 3, after the epithelium of the embodiment of the invention 1,4 was repaired medicated powder and ointment treatment, in one month, 22 routine patients' muscle covered with, and the hands functional rehabilitation is in during skin growth recovers effective percentage 100% at present.
D, chronic rhinitis 50 examples, the epithelium of the use embodiment of the invention 2,4 are cured 20 examples after repairing medicated powder and ointment treatment fully, cure 25 examples basically, effective percentage 90%.
Figure 433300DEST_PATH_IMAGE002
Figure 2011102735579100002DEST_PATH_IMAGE003

Claims (1)

1. an epithelium is repaired medicine, it is characterized in that being made up of the crude drug of following mass parts:
Rhizoma Coptidis 10-20 Sanguis Draxonis 5-10
Margarita powder 10-20 Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20
Radix Angelicae Dahuricae 5-10 Radix Arnebiae (Radix Lithospermi) 25-35
Flos Carthami 5-15.
CN2011102735579A 2011-09-15 2011-09-15 Skin membrane repair drug Active CN102302678B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
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Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2011102735579A CN102302678B (en) 2011-09-15 2011-09-15 Skin membrane repair drug

Publications (2)

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CN102302678A true CN102302678A (en) 2012-01-04
CN102302678B CN102302678B (en) 2013-01-02

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104383286A (en) * 2014-12-08 2015-03-04 湖南科技大学 Paste for treating burns and scalds and preparation method of paste
CN104547566A (en) * 2014-12-24 2015-04-29 李永辉 Rhinitis treating powder capable of refreshing brain, refreshing lung, relieving sore throat and alleviating pain and preparation method of powder
CN104644805A (en) * 2015-01-17 2015-05-27 李秀霞 Traditional Chinese medicine ointment and nursing method for treatment of infant red buttock
CN105796718A (en) * 2016-04-10 2016-07-27 陕西省中医医院 Skin care agent and preparation method thereof
CN106110022A (en) * 2016-07-27 2016-11-16 廖全元 A kind of burn without treating acne, scald, the medicinal liquid and preparation method thereof of wound
CN108853346A (en) * 2018-09-25 2018-11-23 河南中医药大学 A kind of external-applied ointment for treating cheilitis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王茂先: "中国中医烫伤药的研究概述", 《科技资讯》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104383286A (en) * 2014-12-08 2015-03-04 湖南科技大学 Paste for treating burns and scalds and preparation method of paste
CN104547566A (en) * 2014-12-24 2015-04-29 李永辉 Rhinitis treating powder capable of refreshing brain, refreshing lung, relieving sore throat and alleviating pain and preparation method of powder
CN104644805A (en) * 2015-01-17 2015-05-27 李秀霞 Traditional Chinese medicine ointment and nursing method for treatment of infant red buttock
CN105796718A (en) * 2016-04-10 2016-07-27 陕西省中医医院 Skin care agent and preparation method thereof
CN106110022A (en) * 2016-07-27 2016-11-16 廖全元 A kind of burn without treating acne, scald, the medicinal liquid and preparation method thereof of wound
CN108853346A (en) * 2018-09-25 2018-11-23 河南中医药大学 A kind of external-applied ointment for treating cheilitis

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Effective date of registration: 20180223

Address after: 650000 Kunming, Kunming, Yunnan Province, information industry base, Yunnan sea return Venture Park, 9 2 buildings 201, 202

Patentee after: Yunnan yuncaotang Cosmetics Co., Ltd.

Address before: Nanping Street 650021 Yunnan city of Kunming province No. 88 Century Square B1-11-C

Patentee before: He Daming