CN102228661B

CN102228661B - Chinese medicinal cholecystitis treatment mixture for treating chronic cholecystitis

Info

Publication number: CN102228661B
Application number: CN 201110157185
Authority: CN
Inventors: 刘东升
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-05-31
Filing date: 2011-05-31
Publication date: 2013-01-30
Anticipated expiration: 2031-05-31
Also published as: CN102228661A

Abstract

The invention discloses a Chinese medicinal mixture for treating chronic cholecystitis. Chinese doctors believe that the disease is mainly caused by qi stagnation, moist heat, blood stasis and impairment of yin and is treated on the basis of the principle of purgation and gallbladder soothing, so that the traditional Chinese medicines of giant knotweed, figwort root, akebia stem, szechuan lovage rhizome, desmodium, virgate wormwood herb, turmeric root tuber, safflower, frankincense, officinal magnolia bark, rhizoma corydalis, tangerine peel, citrus peel and combined spicebush root which have the effects of purgating, eliminating heat, soothing liver-gallbladder, promoting the circulation of qi and relieving pain are carefully selected and are prepared into the mixture in a preparation room of the hospital of the inventor to be taken by a patient. Clinical tests show that the total effectiveness ratio is 96.7 percent; and the mixture has quick response and low cost and is worthy of wide clinical application.

Description

A kind of herb mixture for the treatment of chronic cholecystitis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of chronic cholecystitis.

Background technology

Chronic cholecystitis is one of clinical modal hepatobiliary system disease.Modern medicine thinks that primary disease is that the chronic inflammatory disease of gallbladder sexually revises, and is the result that acute cholecystitis is repeatedly shown effect.The patient has the greasy phenomenon of flatulence, belch and anorexia usually, often feels epigastric discomfort after being satiated with food, and can ease the pain after food unlike duodenal ulcer.The normal sense of patient has under the right scapula, under the right season rib or right waist etc. locate dull pain, stand, more obvious after motion or the psychrolusia.Because often dull pain is uncomfortable, patient's little motion, body weight often alleviates to some extent.In case when because of the calculus incarceration acute attack being arranged, upper right abdomen will have frequent dull pain, and the paroxysmal aggravation is arranged, the visible thickening of capsule wall of gallbladder of imaging examination, gallbladder contraction function is poor.

At present, the main Drug therapy of method and the operative treatment for the treatment of chronic cholecystitis, Drug therapy mainly is the method for anti-inflammatory and choleretic, such as XIAOYAN LIDAN PIAN, phenylpropanol-yichang, trepibutone, DANTONG, dehydrocholic acid and ursodeoxycholic acid etc., some patient is effective, but relapse rate is high, and therapeutic effect is undesirable; The operative treatment cholecystitis be one of modal operation of present abdominal surgery, but also there is drawback in operative treatment, and namely wound is large, and postoperative easily produces complication.

Summary of the invention

The purpose of this invention is to provide a kind of herb mixture for the treatment of chronic cholecystitis, the traditional Chinese medical science thinks that the stagnation of QI, damp and hot, blood stasis, the cloudy wound are to cause this sick reason, and treatment is take the purging FU-organs function of gallbladder promoting as principle, should eliminating heat pathogen by purging the bowels to reach, and depressed liver-energy dispersing and function of gallbladder promoting, the purpose of promoting the circulation of QI to relieve pain.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine gallbladder health-care composition of this treatment chronic cholecystitis is made by the Chinese medicine of following weight portion: Rhizoma Polygoni Cuspidati 7-12 part, Radix Scrophulariae 7-9 part, Caulis Akebiae 10-15 part, Rhizoma Chuanxiong 7-9 part, Herba Lysimachiae 10-15 part, Herba Artemisiae Scopariae 9-12 part, Radix Curcumae 9-12 part, Flos Carthami 7-11 part, Olibanum 7-11 part, Cortex Magnoliae Officinalis 9-12 part, Rhizoma Corydalis 10-15 part, Pericarpium Citri Reticulatae 9-11 part, Fructus Aurantii Immaturus 7-9 part, Radix Linderae 5-8 part.

Preferably, the Chinese medicine gallbladder health-care composition of this treatment chronic cholecystitis is made by the Chinese medicine of following weight portion: 9 parts of Rhizoma Polygoni Cuspidati, 8 parts of Radix Scrophulariaes, 12 parts of Caulis Akebiaes, 8 parts of Rhizoma Chuanxiongs, 13 parts of Herba Lysimachiaes, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Curcumaes, 9 parts on Flos Carthami, 9 parts of Olibanums, 11 parts of Cortex Magnoliae Officinalis, 13 parts of Rhizoma Corydalis, 10 parts of Pericarpium Citri Reticulataes, 8 parts of Fructus Aurantii Immaturuss, 6 parts of the Radixs Linderae.

Preparation method:

Take by weighing in proportion above each medicine, be ground into coarse powder, connect percolation, make solvent with 57% ethanol, flood after 24 hours, with about 1 milliliter the speed percolation slowly of per minute, filter approximately 700 milliliters of liquid of collection, decompression recycling ethanol, and be concentrated into approximately 170 milliliters, take out, add 200 milliliters in water, boiled 30 minutes, left standstill 48 hours, filter, a small amount of water washing of filtering residue, washing liquid is incorporated in the filtrate, be evaporated to approximately 180 milliliters, add stupid sodium formate 1.5 grams, stir evenly, left standstill 24 hours, filter, add 250 milliliters in water, stir evenly, and get final product.

Rhizoma Polygoni Cuspidati, Radix Scrophulariae, Caulis Akebiae, Rhizoma Chuanxiong eliminating heat pathogen by purging the bowels in the side; Herba Lysimachiae Herba Artemisiae Scopariae, Radix Curcumae depressed liver-energy dispersing and function of gallbladder promoting; Flos Carthami, Olibanum blood circulation promoting and blood stasis dispelling; Cortex Magnoliae Officinalis, Rhizoma Corydalis, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Radix Linderae promoting the circulation of QI to relieve pain; All medicines share, altogether the effect of long memorial liver function of gallbladder promoting, heat clearing away circulation of qi promoting, anti-inflammatory analgetic.

Clinical data

1, whole 120 examples of physical data are Digestive System Department out-patient to our hospital, are divided at random 2 groups.Treatment group 60 examples, male 37 examples, women 23 examples: age 18-80 year, average (46 ± 8.5) year; The course of disease 5 months～28 years; Matched group 60 examples, male 31 examples, women 29 examples: 19～81 years old age, average (45 ± 7.8) year; The course of disease 6 months～29 years.2 groups of case physical data comparing difference not statistically significants (P＞0.05) have comparability.

2, the diagnostic criteria Standards of Chinese Medical Syndrome Differentiation adopts the standard of Ministry of Public Health " new Chinese medicine guideline of clinical investigations " formulation.Syndrome of stagnation of QI: the frequent pain of right rib abdominal part, or the paroxysmal aggravation is arranged, and pain is drawn the shoulder back of the body, bitter taste, and inappetence, upper right abdomen has mild tenderness, and body of the tongue is light red, tongue fur white or little Huang, stringy and thready pulse or stringy and tense pulse.Syndrome of blood stasis: twinge is arranged during right rib abdominal part, and sore spot is fixing not to be moved, under the rib or long-pending piece is arranged, and the complexion sooting, lip is purple dark, red tongue or ecchymosis is arranged, tongue fur is white, deep pulse or puckery.

3, the Therapeutic Method treatment group is taken Chinese medicine gallbladder health-care composition, every day 3 times, each 50 milliliters; Matched group is taken cefalexin capsule (Harbin Pharmaceutical Group three smart pharmaceutcal corporation, Ltds produce), and is each 0.25, every day 3 times.Two groups equal 10 days be a course for the treatment of, observe the curative effect after two courses for the treatment of, viewing duration is withdrawn other drug.

4, criterion of therapeutical effect is determined curative effect with reference to " new Chinese medicine guideline of clinical investigations ".Clinical recovery: symptom, somatic feature score reduce＞95%, and image check is normal: produce effects: symptom, somatic feature score reduce＞70%, and imaging examination meets the produce effects standard; Effectively: symptom, integration reduce＞30%, and imaging examination reaches effective standard; Invalid: symptom, somatic feature score reduce＜30%, and imaging examination is all without improving.

5, therapeutic outcome

Clinical efficacy comparison sees Table one before and after (1) two group for the treatment of

Table 1 liang group curative effect statistics

The total effective rate for the treatment of group is 96.7%, and matched group is that 78.3%, two group of total effective rate comparing difference has statistical significance P＜0.01).

Gall bladder B mode ultrasound imaging checks that integration change situation sees Table two before and after (2) two groups of treatments

Gall bladder B mode ultrasound imaging integral contrast before and after the table 2 liang group treatment (X ± S)

Ultrasound diagnosis integration no significant difference (P＞0.05) before two groups of treatments.After the treatment, two groups of integrations all significantly descend.Before and after two groups of treatments differences relatively, difference has significant (P＜0.01), illustrates that treatment group improves the curative effect of gallbladder contraction function and pathological change and be better than matched group.

The specific embodiment

Embodiment one: take by weighing Rhizoma Polygoni Cuspidati 9g, Radix Scrophulariae 8g, Caulis Akebiae 12g, Rhizoma Chuanxiong 8g, Herba Lysimachiae 13g, Herba Artemisiae Scopariae 10g, Radix Curcumae 10g, Flos Carthami 9g, Olibanum 9g, Cortex Magnoliae Officinalis 11g, Rhizoma Corydalis 13g, Pericarpium Citri Reticulatae 10g, Fructus Aurantii Immaturus 8g, Radix Linderae 6g.Preparation method: take by weighing in proportion above each medicine, be ground into coarse powder, connect percolation, make solvent with 57% ethanol, flood after 24 hours, with about 1 milliliter the speed percolation slowly of per minute, filter approximately 700 milliliters of liquid of collection, decompression recycling ethanol, and be concentrated into approximately 170 milliliters, take out, add 200 milliliters in water, boiled 30 minutes, left standstill 48 hours, filter, a small amount of water washing of filtering residue, washing liquid is incorporated in the filtrate, be evaporated to approximately 180 milliliters, add stupid sodium formate 1.5 grams, stir evenly, left standstill 24 hours, filter, add 250 milliliters in water, stir evenly, and get final product.

Embodiment two: take by weighing Rhizoma Polygoni Cuspidati 12g, Radix Scrophulariae 7g, Caulis Akebiae 15g, Rhizoma Chuanxiong 7g, Herba Lysimachiae 10g, Herba Artemisiae Scopariae 9g, Radix Curcumae 12g, Flos Carthami 7g, Olibanum 11g, Cortex Magnoliae Officinalis 12g, Rhizoma Corydalis 10g, Pericarpium Citri Reticulatae 11g, Fructus Aurantii Immaturus 7g, Radix Linderae 8g.Preparation method: take by weighing in proportion above each medicine, be ground into coarse powder, connect percolation, make solvent with 57% ethanol, flood after 24 hours, with about 1 milliliter the speed percolation slowly of per minute, filter approximately 700 milliliters of liquid of collection, decompression recycling ethanol, and be concentrated into approximately 180 milliliters, take out, add 250 milliliters in water, boiled 30 minutes, left standstill 48 hours, filter, a small amount of water washing of filtering residue, washing liquid is incorporated in the filtrate, be evaporated to approximately 200 milliliters, add stupid sodium formate 1.5 grams, stir evenly, left standstill 24 hours, filter, add 220 milliliters in water, stir evenly, and get final product.

Embodiment three: take by weighing Rhizoma Polygoni Cuspidati 7g, Radix Scrophulariae 9g, Caulis Akebiae 10g, Rhizoma Chuanxiong 9g, Herba Lysimachiae 15g, Herba Artemisiae Scopariae 12g, Radix Curcumae 9g, Flos Carthami 11g, Olibanum 7g, Cortex Magnoliae Officinalis 9g, Rhizoma Corydalis 15g, Pericarpium Citri Reticulatae 9g, Fructus Aurantii Immaturus 9g, Radix Linderae 5g.Preparation method: take by weighing in proportion above each medicine, be ground into coarse powder, connect percolation, make solvent with 57% ethanol, flood after 24 hours, with about 1 milliliter the speed percolation slowly of per minute, filter approximately 700 milliliters of liquid of collection, decompression recycling ethanol, and be concentrated into approximately 160 milliliters, take out, add 220 milliliters in water, boiled 30 minutes, left standstill 48 hours, filter, a small amount of water washing of filtering residue, washing liquid is incorporated in the filtrate, be evaporated to approximately 190 milliliters, add stupid sodium formate 1.5 grams, stir evenly, left standstill 24 hours, filter, add 210 milliliters in water, stir evenly, and get final product.

Claims

1. herb mixture for the treatment of chronic cholecystitis is characterized in that this controls herb mixture and made by the Chinese medicine of following weight portion: Rhizoma Polygoni Cuspidati 7-12 part, Radix Scrophulariae 7-9 part, Caulis Akebiae 10-15 part, Rhizoma Chuanxiong 7-9 part, Herba Lysimachiae 10-15 part, Herba Artemisiae Scopariae 9-12 part, Radix Curcumae 9-12 part, Flos Carthami 7-11 part, Olibanum 7-11 part, Cortex Magnoliae Officinalis 9-12 part, Rhizoma Corydalis 10-15 part, Pericarpium Citri Reticulatae 9-11 part, Fructus Aurantii Immaturus 7-9 part, Radix Linderae 5-8 part.

2. a kind of herb mixture for the treatment of chronic cholecystitis according to claim 1 is characterized in that this herb mixture made by the Chinese medicine of following weight portion: 9 parts of Rhizoma Polygoni Cuspidati, 8 parts of Radix Scrophulariaes, 12 parts of Caulis Akebiaes, 8 parts of Rhizoma Chuanxiongs, 13 parts of Herba Lysimachiaes, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Curcumaes, 9 parts on Flos Carthami, 9 parts of Olibanums, 11 parts of Cortex Magnoliae Officinalis, 13 parts of Rhizoma Corydalis, 10 parts of Pericarpium Citri Reticulataes, 8 parts of Fructus Aurantii Immaturuss, 6 parts of the Radixs Linderae.