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CN102215847B - 碳酸钙片剂的改善的溶出稳定性 - Google Patents

碳酸钙片剂的改善的溶出稳定性 Download PDF

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Publication number
CN102215847B
CN102215847B CN200980145721.9A CN200980145721A CN102215847B CN 102215847 B CN102215847 B CN 102215847B CN 200980145721 A CN200980145721 A CN 200980145721A CN 102215847 B CN102215847 B CN 102215847B
Authority
CN
China
Prior art keywords
tablet
calcium
sugar alcohol
magnesium stearate
calcium carbonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200980145721.9A
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English (en)
Chinese (zh)
Other versions
CN102215847A (zh
Inventor
佩德·莫尔·奥尔森
保罗·埃贡·贝特尔森
托马斯·迪斯泰德
亨里克·拉文·埃格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wu Tian company limited
Original Assignee
Takeda Nycomed AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Nycomed AS filed Critical Takeda Nycomed AS
Publication of CN102215847A publication Critical patent/CN102215847A/zh
Application granted granted Critical
Publication of CN102215847B publication Critical patent/CN102215847B/zh
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN200980145721.9A 2008-11-17 2009-11-17 碳酸钙片剂的改善的溶出稳定性 Active CN102215847B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08169264 2008-11-17
EP08169264.2 2008-11-17
PCT/EP2009/008157 WO2010054845A1 (en) 2008-11-17 2009-11-17 Improved dissolution stability of calcium carbonate tablets

Publications (2)

Publication Number Publication Date
CN102215847A CN102215847A (zh) 2011-10-12
CN102215847B true CN102215847B (zh) 2014-07-16

Family

ID=40456895

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980145721.9A Active CN102215847B (zh) 2008-11-17 2009-11-17 碳酸钙片剂的改善的溶出稳定性

Country Status (23)

Country Link
US (2) US9101565B2 (pl)
EP (1) EP2358374B1 (pl)
JP (1) JP5523467B2 (pl)
KR (1) KR101807318B1 (pl)
CN (1) CN102215847B (pl)
AU (1) AU2009315917B2 (pl)
BR (1) BRPI0921599B8 (pl)
CA (1) CA2742449C (pl)
CY (1) CY1114885T1 (pl)
DK (1) DK2358374T3 (pl)
EA (1) EA021707B1 (pl)
ES (1) ES2437851T3 (pl)
HK (1) HK1162354A1 (pl)
HR (1) HRP20131084T1 (pl)
IL (1) IL212442A (pl)
MX (1) MX2011004744A (pl)
NZ (1) NZ592528A (pl)
PL (1) PL2358374T3 (pl)
PT (1) PT2358374E (pl)
SI (1) SI2358374T1 (pl)
SM (1) SMT201400014B (pl)
WO (1) WO2010054845A1 (pl)
ZA (1) ZA201103421B (pl)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010054845A1 (en) 2008-11-17 2010-05-20 Nycomed Pharma As Improved dissolution stability of calcium carbonate tablets
CN102905691A (zh) 2010-06-01 2013-01-30 卡吉尔公司 赤藓糖醇和异麦芽酮糖醇的口腔分散片剂
EP3260114A1 (en) * 2016-06-21 2017-12-27 Omya International AG Method for the production of a dosage form
CN107281216B (zh) * 2017-06-16 2020-05-05 北京济美堂医药研究有限公司 含钙化合物的药物制剂
CN110575440A (zh) * 2018-06-08 2019-12-17 北京新领先医药科技发展有限公司 一种碳酸钙药物组合物的制备方法
BR112022000117A2 (pt) 2019-07-05 2022-02-15 Tecnimede Sociedade Tecnico Medicinal Sa Composições compactadas de macitentana, métodos e usos das mesmas.
JP2023054786A (ja) * 2021-10-04 2023-04-14 備前化成株式会社 食品錠剤の製造方法
WO2024028300A1 (en) * 2022-08-04 2024-02-08 Symrise Ag Process for the preparation of a powder or of a pastille
KR102675165B1 (ko) * 2023-02-20 2024-06-13 동아제약 주식회사 필름 코팅용 조성물 및 이를 포함하는 필름 코팅액

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1997362A (zh) * 2004-06-01 2007-07-11 奈科明制药有限公司 包括含钙化合物作为活性物质的可咀嚼、可吮吸和可吞咽片剂
CN101001611A (zh) * 2004-05-24 2007-07-18 奈科明制药有限公司 包括含钙化合物和糖醇的微粒

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US4115553A (en) * 1973-12-10 1978-09-19 Armour Pharmaceutical Company Antacid tablets
US5204115A (en) 1990-12-12 1993-04-20 Suomen Xyrofin Oy Directly compressible xylitol and method
JP2995226B2 (ja) 1992-03-03 1999-12-27 日本ワイスレダリー株式会社 カルシウム含有チユアブル錠
US5405623A (en) 1993-09-22 1995-04-11 Wm. Wrigley Jr. Company Chewing gum compositions and methods for manufacturing same
DE4427137B4 (de) 1993-10-07 2007-08-23 Degussa Gmbh Fällungskieselsäure
US6716454B2 (en) * 1994-09-23 2004-04-06 Laboratorie Innothera, Société Anonyme Therapeutic combination of vitamin and calcium in unitary galenic tablet form, a method of obtaining it, and the use thereof
FR2724844B1 (fr) 1994-09-23 1997-01-24 Innothera Lab Sa Association therapeutique vitamino-calcique, son procede d'obtention et son utilisation
US5846506A (en) 1994-10-07 1998-12-08 Degussa Aktiengesellschaft Precipitated silicas
DE19617487A1 (de) 1996-05-02 1997-11-06 Merck Patent Gmbh Geschmacksverbesserung von Arzneimittelwirkstoffen
EP0914818B1 (en) 1996-06-14 2005-06-08 Kyowa Hakko Kogyo Co., Ltd. Intraorally rapidly disintegrable tablet
FR2762217B1 (fr) 1997-04-16 2000-09-29 Besins Iscovesco Lab Preparation solide vitamino-calcique, son procede d'obtention et son utilisation
ITFI970184A1 (it) 1997-07-30 1999-01-30 Menarini Farma Ind Composizioni farmaceutiche contenenti vitamina d e calcio,loro preparazione ed uso terapeutico
GB9825033D0 (en) 1998-11-13 1999-01-13 Nycomed Pharma As Process
JP2001316249A (ja) 2000-05-11 2001-11-13 Lion Corp 錠剤型医薬組成物
CA2440365A1 (en) 2001-03-06 2002-09-12 Kyowa Hakko Kogyo Co., Ltd. Use of a spray-dried powder comprising a sugar alcohol
US20040071772A1 (en) 2001-03-06 2004-04-15 Shoichi Narita Preparations quickly disintegrating in oral cavity
WO2003007917A1 (en) * 2001-07-16 2003-01-30 Astrazeneca Ab Pharmaceutical formulation comprising a proton pump inhibitor and antacids
ES2192136B1 (es) 2002-01-04 2005-03-16 Italfarmaco, S.A. Composiciones farmaceuticas para el tratamiento o prevencion de la osteoporosis.
DE20216314U1 (de) 2002-10-22 2003-12-04 Dhw Deutsche Hydrierwerke Gmbh Rodleben Sprühgetrockneter Xylitol und aus diesem hergestellte Komprimate
ATE395908T1 (de) * 2005-02-03 2008-06-15 Nycomed Pharma As Schmelzgranulation einer zusammensetzung mit einer calziumhaltigen verbindung
AU2006322452B2 (en) * 2005-12-07 2012-07-12 Takeda Nycomed As Pre-compacted calcium-containing compositions
UA95093C2 (uk) * 2005-12-07 2011-07-11 Нікомед Фарма Ас Спосіб одержання кальцієвмісної сполуки
US8325659B2 (en) 2007-01-16 2012-12-04 Koninklijke Philips Electronics N.V. Device discovery for mixed types of directional terminals
WO2010054845A1 (en) 2008-11-17 2010-05-20 Nycomed Pharma As Improved dissolution stability of calcium carbonate tablets

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101001611A (zh) * 2004-05-24 2007-07-18 奈科明制药有限公司 包括含钙化合物和糖醇的微粒
CN1997362A (zh) * 2004-06-01 2007-07-11 奈科明制药有限公司 包括含钙化合物作为活性物质的可咀嚼、可吮吸和可吞咽片剂

Also Published As

Publication number Publication date
JP5523467B2 (ja) 2014-06-18
CA2742449A1 (en) 2010-05-20
DK2358374T3 (da) 2013-11-11
HRP20131084T1 (hr) 2013-12-20
US9101565B2 (en) 2015-08-11
US9999634B2 (en) 2018-06-19
AU2009315917A1 (en) 2010-05-20
PT2358374E (pt) 2013-12-09
EA021707B1 (ru) 2015-08-31
IL212442A0 (en) 2011-06-30
PL2358374T3 (pl) 2014-03-31
ZA201103421B (en) 2012-10-31
MX2011004744A (es) 2011-05-30
SI2358374T1 (sl) 2014-01-31
EP2358374B1 (en) 2013-09-18
SMT201400014B (it) 2014-03-07
CY1114885T1 (el) 2016-12-14
EP2358374A1 (en) 2011-08-24
WO2010054845A1 (en) 2010-05-20
BRPI0921599B1 (pt) 2020-08-18
NZ592528A (en) 2013-05-31
BRPI0921599B8 (pt) 2021-05-25
BRPI0921599A2 (pt) 2016-02-10
US20160022732A1 (en) 2016-01-28
KR101807318B1 (ko) 2018-01-10
JP2012508706A (ja) 2012-04-12
AU2009315917B2 (en) 2014-11-20
CN102215847A (zh) 2011-10-12
KR20110086592A (ko) 2011-07-28
CA2742449C (en) 2018-04-24
HK1162354A1 (en) 2012-08-31
EA201170695A1 (ru) 2011-12-30
US20110287098A1 (en) 2011-11-24
IL212442A (en) 2015-10-29
ES2437851T3 (es) 2014-01-14

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