CN102204956B - Chinese medicinal composition used at stroke recovery period and preparation method thereof - Google Patents
Chinese medicinal composition used at stroke recovery period and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition used at a stroke recovery period and a preparation method thereof. The Chinese medicinal composition is prepared from the following bulk pharmaceuticals in parts by weight: 20 parts of astragalus, 6 parts of pseudo-ginseng root, 12 parts of red-rooted salvia root, 5 parts of Chinese angelica root and 3 parts of gingko leaves. The invention further provides a preparation containing the Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition provided by the invention is used at the stroke recovery period, can be taken for a long time, and has a determined curative effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition that is used for stroke in convalescent stage and preparation method thereof.
Background technology
Apoplexy (apoplexy), pouncing on unexpected dusk, hemiplegia, dysphasia or aphasia, crooked mouth and tongue, hemianesthesia is main performance, and it is anxious to have onset, change fast, the disease of the characteristics that become like ailment said due to cold or exposure benefaction number.
Apoplexy also is apoplexy.Be divided into two types: in the ischemic cerebral apoplexy and hemorrhagic apoplexy.Apoplexy is the general designation of Chinese medicine to acute cerebrovascular disease.It is suddenly fainting, syncope, the distortion of commissure that occurs together, dysphonia (being that the stiff tongue language is stuttering) and one type of disease that hemiplegia is a cardinal symptom occurs.Because the primary disease sickness rate is high, mortality rate is high, disability rate is high, relapse rate is high and complication is many, so medical circle is listed as its same coronary heart disease, cancer one of three big diseases that threaten human health.The importance of prevention of stroke has caused the attention of domestic and international medical circle, and physicians explore the preventive measure of apoplexy just in all its bearings.
Along with the continuous improvement of medical condition and the raising day by day of medical technique level, the success rate of rescuing the paralytic also is greatly improved.Yet, how to prevent second stroke, but be the new problem that medical worker and patient and family members thereof face.Though many stroke patients pull through through rescuing,, thereby brought numerous adverse effects for society and family because second stroke has caused death or sequela to be difficult to recover.Relevant clinical observation and statistical result show; Though cause the reason of stroke patient generation second stroke a lot (like dietary habit, excited, climate changes, overwork or the like); But most important reason is to take medicine improper or fail to adhere to take medicine, and still has many patients also not to be fully recognized that importance and relevant medication knowledge that stroke in convalescent stage is taken medicine so far.Numerous clinical practice experiences are told us, and the stroke in convalescent stage patient not only will continue medication, and medication also must be adhered to following three principles:
The first, must adhere to taking medicine for a long time
After stroke in convalescent stage is generally after 2 weeks of cerebral infarction morbidity or cerebral hemorrhage was fallen ill 1 month, most of long, generally need 3～12 months.The patient who spends acute stage still needs the active treatment one-year age, will adhere to medication in this year.
According to the clinical data statistics, the relapse rate of apoplexy in 1 year is 25-30%, and the relapse rate in 1 year is 17-20%, and the relapse rate in the 3rd year is 20-23%, and the relapse rate in the 4th year is 15-18%, and the relapse rate in the 5th year is 5-9%.This shows that preferably can adhere to that relapse rate just can obviously reduce like this medicine time of stroke patient 5 years.
The second, preferably select Chinese patent medicine for use
Which type of medicine the stroke in convalescent stage patient should select for use, is the problem that patient and family members thereof very are concerned about.Many people often can only select medicine owing to lack the knowledge of this respect from media advertisements such as newspaper, TV, this can not be according to the concrete condition of self, blindly the way according to the advertising medication is very unscientific, also is extremely harmful.
From the angle of prevention of stroke recurrence and treatment sequela, no matter medical circle is the traditional Chinese medical science or doctor trained in Western medicine, thinks that more as one man the stroke in convalescent stage patient should select Chinese medicine preparation for use.Certainly, take Chinese herbs decoction for a long time and also exist inconvenience, bigger or the like as all decocting Chinese medicine, each dose every day.
But, along with the continuous development of Chinese medicine preparation, the existing now Chinese patent medicine that much is suitable for stroke in convalescent stage patient use comes out, like XUESHUANXINMAINING, NAOXUESHUAN PIAN, ZHONGFENG HUICHUN WAN, HUATUO ZAIZAO WAN, DAHUOLUO DAN or the like.
Patient can according to concrete conditions such as the state of an illness and body constitution, select to take under doctor's guidance targetedly.In case of necessity, also can be used some has the Chinese patent medicine of transferring the benefit effect, like QI invigorating, YIN nourishing, warming YANG, blood nourishing class medicine, just can obtain more ideal effect like this.
The 3rd, can not extravagantly hope specific drug
Many stroke patients and family members thereof ask more anxious; Always think to find one or more specific drugs, can obtain rehabilitation in a short time after the use, or effectively prevent recurrence; Some people even think that by error imported medicine, valuable medicine have been exactly medicine, specific drug is so use to patient at all costs.In fact, with regard to stroke patient, owing to the cause of disease of bringing out apoplexy is very complicated; Diseases such as hypertension, hyperlipidemia, high blood viscosity, hyperglycemia are arranged; These diseases all belong to chronic disease, and its treatment also all needs a very long process, so stroke in convalescent stage patient's medication is also just more complicated.
Patent CN200910077208.2 discloses by 20 parts of the Radixs Astragali, 6 parts of Radix Notoginseng, 12 parts of Radix Salviae Miltiorrhizaes, 9 parts of Radix Angelicae Sinensis, 10 parts of Chinese medicine compound of processing of Folium Ginkgo; This compound recipe is mainly used in cardiovascular and cerebrovascular disease; Have the blood viscosity of improvement, the effect of increasing blood flow speed mainly act as blood circulation promoting and blood stasis dispelling.Wherein 9 parts of Radix Angelicae Sinensis consumptions, 10 parts of Folium Ginkgo consumptions are too much because Folium Ginkgo eats, can toxigenicity.
Therefore need provide a kind of can take for a long time, and can play the medicine of definite curative effect at stroke in convalescent stage.
Summary of the invention
The Chinese medicine composition that is used for stroke in convalescent stage that the purpose of this invention is to provide a kind of determined curative effect.
Another object of the present invention provides the method for distilling of this Chinese medicine composition.
Another object of the present invention is to provide a kind of preparation that contains this Chinese medicine composition.
The present invention also provides a kind of preparation to contain the method for the preparation of this Chinese medicine composition.
Last purpose of the present invention is to provide the application of this Chinese medicine composition.
A kind of Chinese medicine composition that is used for stroke in convalescent stage provided by the invention is processed by following bulk drugs: 20 parts of the Radixs Astragali, 6 parts of Radix Notoginseng, 12 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Angelicae Sinensis, 3 parts of Folium Ginkgos.
The present invention also provides the method for distilling of above-mentioned Chinese medicine composition, may further comprise the steps:
1) Radix Astragali adds 8 times of amount 30% ethanol with alcohol reflux twice at every turn, extracts 4 hours, and merge extractive liquid, filters, and relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
2) Folium Ginkgo adds 8 times of amount 75% ethanol with alcohol reflux twice at every turn, extracts 3 hours, and the united extraction thing filters, and relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
3) Radix Notoginseng, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae three flavor medicines, decocte with water twice, add the water of 10 times of amounts the first time, decocted 2 hours; Add for the second time the water of 8 times of amounts, decocted collecting decoction 1 hour; Filter, relative density was the clear paste of 1.10-1.13 when filtrating was concentrated into 70 ℃, added ethanol and made that containing the alcohol amount reaches 65%; Left standstill 24 hours, and filtered, relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
4) merge above-mentioned clear paste, be spray dried to dried cream powder.
The present invention also provides the preparation that contains the Chinese medicine composition that is used for stroke in convalescent stage, and said preparation is by Chinese medicine composition and pharmaceutically acceptable carrier or diluent.
The present invention also provides the method for preparing above-mentioned preparation, and this method may further comprise the steps:
1) Radix Astragali adds 8 times of amount 30% ethanol with alcohol reflux twice at every turn, extracts 4 hours, and merge extractive liquid, filters, and relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
2) Folium Ginkgo adds 8 times of amount 75% ethanol with alcohol reflux twice at every turn, extracts 3 hours, and the united extraction thing filters, and relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
3) Radix Notoginseng, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae three flavor medicines, decocte with water twice, add the water of 10 times of amounts the first time, decocted 2 hours; Add for the second time the water of 8 times of amounts, decocted collecting decoction 1 hour; Filter, relative density was the clear paste of 1.10-1.13 when filtrating was concentrated into 70 ℃, added ethanol and made that containing the alcohol amount reaches 65%; Left standstill 24 hours, and filtered, relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
4) merge above-mentioned clear paste, be spray dried to dried cream powder;
5) get dried cream powder and pharmaceutically acceptable carrier or mixing diluents, process preparation with conventional method for preparing.
In the foregoing, wherein:
Said pharmaceutically acceptable carrier or diluent are selected from one or more in lactose, starch, dextrin, mannitol, sucrose, hydroxypropyl methylcellulose, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, magnesium stearate or the Pulvis Talci.
Said preparation is solid preparation or liquid preparation, and solid preparation is tablet, capsule, granule, drop pill; Liquid preparation is injection, mixture or oral liquid, and dosage form is preferably granule.
The present invention also provides the application of above-mentioned Chinese medicine composition in the medicine of preparation treatment stroke in convalescent stage.
The Chinese medicine composition that is used for stroke in convalescent stage provided by the invention has the following advantages:
1) definite ingredients, method for preparing is simple;
2) compared by 20 parts of the Radixs Astragali, 6 parts of Radix Notoginseng, 12 parts of Radix Salviae Miltiorrhizaes, 9 parts of Radix Angelicae Sinensis, 10 parts of compound recipes of forming of Folium Ginkgo with CN200910077208.2 is disclosed, the present invention has following difference:
Radix Angelicae Sinensis and Folium Ginkgo consumption are few, and the consumption of Folium Ginkgo especially obviously reduces than the consumption of this patent, has avoided the cumulative toxicity of stroke in convalescent stage long-term prescription.
3) extract drugs method provided by the invention, also different with the method for distilling of CN200910077208.2, cause pharmacological effect also different.
Radix Angelicae Sinensis contains the ferulic acid composition, is water soluble ingredient, adopts water extraction, and the content of the ferulic acid composition that obtains is apparently higher than the method (adopting 60% ethanol extraction) of CN200910077208.2, and ferulic acid wherein is used to treat the better effects if of stroke in convalescent stage.
Contain antithrombotic composition-danshensu constituents in the Radix Salviae Miltiorrhizae; It is high than the 60% ethanol extraction rate of CN200910077208.2 to adopt water to carry, and strengthened following drug action: VPV is accelerated, and fluidised form is improved; The erythrocyte depolymerization; The protection cerebral ischemia, microcirculation improvement, thus make the better effects if of treating stroke in convalescent stage.
Through pharmacology and clinical trial, the material that Chinese medicine composition of the present invention and preparation method thereof obtains is obviously different with CN200910077208.2, and drug effect increases.
4) Chinese medicine provided by the invention has the benefiting QI for activating blood circulation effect, is applicable to that stroke in convalescent stage belongs to syndrome of blood stasis due to qi deficiency rehabilitation of patients and auxiliary treatment, and disease is seen hemiplegia, and the stiff tongue language is stuttering, the weak weak point of gas, and spontaneous perspiration etc., effective than the optimizing prescriptions of CN200910077208.2.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1: the method for distilling that is used for the Chinese medicine composition of stroke in convalescent stage
1) Radix Astragali adds 8 times of amount 30% ethanol with alcohol reflux twice at every turn, extracts 4 hours, and merge extractive liquid, filters, and relative density was 1.13～1.15 clear paste when filtrating was concentrated into 70 ℃;
2) Folium Ginkgo adds 8 times of amount 75% ethanol with alcohol reflux twice at every turn, extracts 3 hours, and the united extraction thing filters, and relative density was 1.13～1.15 clear paste when filtrating was concentrated into 70 ℃;
3) three flavor medicines such as Radix Notoginseng, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, decocte with water twice, add the water of 10 times of amounts the first time, decocted 2 hours; Add for the second time the water of 8 times of amounts, decocted collecting decoction 1 hour; Filter, relative density was 1.10～1.13 clear paste when filtrating was concentrated into 70 ℃, added ethanol and made that containing the alcohol amount reaches 65%; Left standstill 24 hours, and filtered, relative density was 1.13～1.15 clear paste when filtrating was concentrated into 70 ℃;
4) merge above-mentioned clear paste, be spray dried to dried cream powder.
Embodiment 2: granule
The Chinese medicine composition extract of embodiment 1 preparation is mixed with the dextrin of identical weight, and dry granulation is processed granule.
Usage and dosage: 1 3g (being equivalent to the 3g crude drug), every day 3 times.
Embodiment 3: adopt the Chinese medicine of CN200910077208.2 to form and method for distilling, the method for preparing with reference to the embodiment of the invention 2 is made into granule, and is specific as follows:
1, method for distilling: the ethanol with Radix Salviae Miltiorrhizae, Radix Notoginseng, Folium Ginkgo, Radix Angelicae Sinensis, Radix Astragali adding 60%, extract 2 times, merging filtrate reclaims ethanol, and rare extractum is dissolved in water, and filters, and filtrating is concentrated into the extractum that relative density is 1.35-1.39 (55 ℃); Merge above-mentioned extractum, be spray dried to dried cream powder;
2, get dry extract with etc. the dextrin of weight mix, dry granulation is processed granule.
Embodiment 4: effect experiment (animal experiment)
One, to the influence of rabbit vertebral artery and common carotid artery blood flow
1, trial drug: get the granule of embodiment 2 preparations, called after hat protection granules is got the granule of embodiment 3 preparations, the called after matched group.
2, experimental animal: rabbit 2.5-3.0kg, half and half, 46 of male and female.
3, experimental technique:
Rabbit is divided into hat at random protects high, medium and low dose groups (2.12g/kg body weight, 10.6g/kg body weight, 20.8g/kg body weight), positive controls (13.13g/kg body weight) and solvent matched group, every group of 8 rabbit.
3% pentobarbital sodium 25mg/kg intravenous injection anesthesia; Separate common carotid artery and vertebral artery; Place sizeable electromagnetic flowmeter probe respectively, after waiting to stablize 1h, each is organized rabbit and gives hat protection granules agent and positive controls and solvent respectively; Relatively a medicine increases percentage rate to common carotid artery and vertebral artery blood flow, and carries out statistical procedures.
4, experimental result:
Table 1: hat is protected exempting from the influence of cerebral blood flow
Compare with the solvent matched group:
#P＜0.05,
##P＜0.01 is compared with matched group,
※P＜0.05,
※ ※P＜0.01.
Can find out from the result of the test of table 1: compare with the solvent matched group, the hat protection granules has different increase effect (P＜0.05, P＜0.01) with matched group to rabbit vertebral artery and Carotid blood flow.Compare the obvious blood flow increasing (P＜0.05) of dose groups during hat is protected, the remarkable blood flow increasing of high dose group (P＜0.01) with matched group.
Two, the influence that thrombus in vivo is formed:
1, experimental animal: Kunming mouse, body weight 18-22g, male and female half and half, totally 48.
2, experiment is divided into groups: be divided into the hat guarantor at random and organize high, medium and low dose groups (the hat protection granules of embodiment 2 preparations), matched group (medicines of embodiment 3 preparations) and solvent matched group.
3, test method:
Every group of mice, gastric infusion three days, fasting is 13 hours before the experiment, and 1h after the last administration, tail vein after the injection, observe each treated animal death condition in the 1h such as thrombosis derivant ADP (adenosine diphosphate sodium) 480mg/kg.
4, statistical method: use X
2The check medicine has unrestraint thrombus in vivo formation effect.
Its Chinese medicine suppresses thrombotic percentage rate computing formula:
5, the result sees table 2:
Table 2: the anti-mice thrombus in vivo of hat protection granules formation effect
Compare with the solvent matched group:
#P＜0.05,
##P＜0.01 is compared with matched group,
※P＜0.05.
Table 2 result confirms: compares with solvent control group, and the effect (P＜0.05, P＜0.01) that hat protection granules and matched group all have antagonism mice thrombus in vivo to form, but the effect of hat guarantor high dose group is better than matched group (P＜0.01).
Three, rat coronary artery is produced the protective effect of myocardial infarction
1, laboratory animal: Wsitar rat, 270 ± 20g, 40.
2, trial drug: get the granule of embodiment 2 preparations, called after hat protection granules is got the granule of embodiment 3 preparations, the called after matched group, and other establishes the solvent matched group.
3, test method:
Continuously gastric infusion is after three days, urethane 0.05g/kg lumbar injection rat anesthesia, back fixation; With more than half picture ball (just in time entangling rat head), link artificial respirator, practice artificial respiration; The chest QUMAO, sterilization is along left mid-clavicular line longitudinal incision skin 2.0cm.At the 4th intercostal, passivity is separated the flesh layer, opens the thoracic cavity, cuts off pericardium; The light right side thoracic wall of pressing is extruded heart, behind ligation left coronary artery in Coronary vein place between arterial cone and the left atrium; Send heart back to thoracic cavity immediately, sew up thoracic wall rapidly, stop the artificial respiration.
Get final product after the operation, 4h, 12h, 24h and 48h; Measure rat standard limbs II lead electrocardiogram, record T wave height is alarmmed, and the ST section such as raises at the typical myocardial ischemia electrocardiogram persistent period; Relatively in three days, each organizes rat and control rats myocardial ischemia persistent period diversity.
4, experimental result (specifically seeing table 3):
Table 3: the hat protection granules influences ligation rat arteria coronaria myocardial infarction
Above-mentioned experimental result shows: each dose groups protected by hat and matched group all has the effect that the ligation coronary artery produces rat myocardium block, myocardial ischemia that resists.
Four, to the rheol influence of rabbit blood
1, laboratory animal: healthy rabbits, 2.5-3.0kg, male and female dual-purpose.
2, experiment medicine: get the granule of embodiment 2 preparations, called after hat protection granules group is got the granule of embodiment 3 preparations, the called after matched group.
3, experiment is divided into groups: rabbit is divided into hat protection granules group (10.6g/kg body weight), matched group (13.13g/kg body weight) and solvent matched group, every group of 8 rabbit at random.
4, test method:
Every group of rabbit gastric infusion once/day, continuous seven days.Respectively gather 5ml blood before and after the administration, form and the platelet adhesion combined instrument, measure hemorheological indexes with the blood capillary viscometer of Shanghai Medical Univ's development and the XSN-R type external thrombus of Wuxi Medical Instruments two factories production.
5, the result shows (seeing table 4 and table 5):
Table 4: to the influence of rabbit WBV
Compare with the solvent matched group:
#P＜0.05,
##P＜0.01 is compared with matched group,
※P＜0.05.
Table 5: the influence of family being exempted from plasma viscosity and packed cell volume
Compare with the solvent matched group:
#P＜0.05,
##P＜0.01 is compared with matched group,
※P＜0.05.
Hat protection granules and matched group all show can reduce rabbit whole blood contrast viscosity (height is cut, hanged down and cut); Plasma viscosity, packed cell volume; Explain that said preparation has the effect of certain blood circulation promoting; The effect of blood viscosity lowering has tangible function of promoting blood circulation to disperse blood clots, and evident difference property (P＜0.05, P＜0.01) is arranged relatively before the administration.Compare with matched group, the effect of hat guarantor group has certain difference (P＜0.05).
The experiment brief summary: the hat protection granules has the effect that increases vertebral artery and CCABF; Can also prevent the formation of thrombosis; And the effect that has antagonism ligation coronary artery to produce rat myocardium block, myocardial ischemia; Can also improve blood viscosity, suppress a series of physiologically actives such as thrombosis, effect is superior to matched group.
Embodiment 5: clinical trial
1, physical data: include 212 routine blood stasis due to qi deficiency disease stroke in convalescent stage patient, wherein cerebral infarction 167 examples, cerebral hemorrhage 28 examples, cerebral thrombosis 20 examples.
2, divide into groups:
Be divided into two groups at random: wherein be preced with the protection granules group and add up to 110 examples, wherein: cerebral infarction 86 examples, cerebral hemorrhage 15 examples, cerebral thrombosis 9 examples; Matched group 105 examples, wherein: cerebral infarction 81 examples, cerebral hemorrhage 13 examples, cerebral thrombosis 11 examples.
3, test method:
Treatment group: select the hat protection granules for use, every day 3 times, each 3g;
Matched group: select the medicine of embodiment 3 for use, every day 3 times, each 3.8g.
Each treatment group was a course of treatment with 60 days all.
4, result:
4.1 efficacy result is seen table 1:
Table 1: each organizes the efficacy result analysis
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate (%) |
| The treatment group | 110 | 63(57.27％) | 41(37.28％) | 6(5.45％) | 103(94.55％) ※ |
| Matched group | 105 | 51(48.57％) | 34(32.38％) | 20(19.05％) | 85(80.95％) |
Compare with matched group,
※P＜0.05.
Can find out from table 1 result: from total effective rate, compare with matched group, the treatment group promptly is preced with the protection granules group and is had notable difference (P＜0.05).
4.2 the efficacy result of apoplexy symptom
Table 3: hemiplegia
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate (%) |
| The treatment group | 88 | 10(11.36％) | 52(59.09％) | 28(29.55％) | 60(70.45％) ※ |
| Matched group | 84 | 7(8.33％) | 37(44.05％) | 40(47.62％) | 44(52.38％) |
Compare with matched group,
※P＜0.05.
Table 4: the stiff tongue language is stuttering
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate (%) |
| The treatment group | 86 | 13(15.12％) | 65(75.58％) | ?8(9.30％) | 78(90.70％) ※ |
| Matched group | 80 | 8(10％) | 52(65％) | ?20(25％) | 60(75％) |
Compare with matched group,
※P＜0.05.
The cardinal symptom total effective rate:
Hemiplegia: the total effective rate of treatment group is 70.45%, and the total effective rate of matched group is 52.38%, compares with matched group, and the treatment group promptly is preced with the protection granules group and is had notable difference (P＜0.05);
The stiff tongue language is stuttering: the total effective rate of treatment group is 90.70%, and the total effective rate of matched group is 75%, compares with matched group, and the treatment group promptly is preced with the protection granules group and is had notable difference (P＜0.05).
The experiment brief summary:
1) the hat protection granules has the obvious treatment effect through clinical inflammation to the Qi deficiency blood stasis type stroke in convalescent stage;
2) the hat protection granules is taken easyly, safe and reliable, has social benefit, economic benefit and potential applicability in clinical practice, makes and promotes the use of;
3) in the therapeutic process, medicine was detained in the mouth after matched group had 4 routine patient's reflections to take medicine, and flavour of a drug are difficult to be removed, and it is uncomfortable to feel throat, can disappear after drinking water repeatedly, and surplus discovery has other untoward reaction;
Embodiment 6: long term toxication
1, laboratory animal: Wistar rat, 80,90 ± 10g, male and female half and half.
2, experiment medicine: the medicine of the embodiment of the invention 2, name is called the hat protection granules; The medicine of embodiment 3, name is called matched group.
3, experiment is divided into groups and experimental technique:
80 rats are divided into the blank group at random, and hat is protected heavy dose of group and middle dose groups, positive controls, and wherein the blank group is irritated an amount of distilled water of clothes every day, and hat is protected heavy dose of group and is given 93.09g crude drug/kg every day; Middle dose groups rat, every day, every Mus was irritated clothes hat protection granules 46.55g crude drug/kg; Positive controls every Mus every day is irritated drug particles 57.68g crude drug/kg body weight of clothes embodiment 3.
Took medicine weekly 6 days, and serve on 90 days.
4, experimental result:
1) respectively organize the standard limb lead electrocardiogram prompting that rat records: the hat protection granules does not have obvious influence to the rat electrocardiogram.
2) except that positive controls, it is normal that each organizes rat morphology.The positive controls rat had 5 rats phenomenons such as transience shaking palsy, neural spasm can occur after 80 days;
3) respectively organize rat body weight natural increase, routine blood test, liver, renal function are all in normal range;
4) pathological examination: main organs pathologic findings such as rat brain, the heart, liver, spleen, lung, kidney, adrenal gland, testis, uterus, harmonization of the stomach intestinal are all normal.
5, sum up: in sum, the long-term oral medicine of the present invention of rat is not found obvious toxic reaction, so the long-term oral medication of preparation of the present invention is a safety non-toxic.And part rat shaking palsy phenomenon (13/80) has taken place in positive controls, possibly be that the Folium Ginkgo consumption is too much, the neural spasm that causes.
Embodiment 7: model case
Xue, man, 60 years old, workman; In on August 19th, 2008 patient under no obvious inducement situation, slobbering appears, stiff tongue language is stuttering, the left limb inconvenient activity; The hemianesthesia sense, dizzy nose heave, but sanity, having a blood test to press is 20/12kpa; Heart rate 68 times/minute, the companion is whole, noise (--), two lungs (--).Muscular strength III, muscular hypertonia, complexion Anhui is simple and unadorned in vain, shortness of breath and fatigue, tongue is dark violet, white and thin fur, deep and hesitant pulse, the head CT inspection shows: multiple cerebral infarction, tcm diagnosis are apoplexy, belong to Qi deficiency blood stasis type.
Take the hat protection granules every day, three times on the one, 3 gram/days are after 20 days; Giddy is nose heave obviously to alleviate, and language performance is normal basically after 20 days, and dizzy heavy, slobbering disappears; Facial hemiparalysis, complexion Anhui are white, and shortness of breath and fatigue greatly takes a turn for the better, the dark white and thin fur of light red tongue, and deep and faint pulse is puckery.
After continuing to take medicine one month, muscular strength is normal basically, hemianesthesia, and distortion of commissure, pale tongue with thin fur are white, deep pulse.Having a blood test to press is 18/11kpa, heart rate 66 times/minute, and the head CT inspection shows: the focus of infarct major part is absorbed, and period in a medicine has not been found significant side effects, is almost recovered.
Though, used general explanation, the specific embodiment and test in the preceding text, the present invention has been done detailed description, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (10)
1. a Chinese medicine composition that is used for stroke in convalescent stage is characterized in that, this Chinese medicine composition is processed by following bulk drugs: 20 parts of the Radixs Astragali, 6 parts of Radix Notoginseng, 12 parts of Radix Salviae Miltiorrhizaes, 5 parts of Radix Angelicae Sinensis, 3 parts of Folium Ginkgos, its method for distilling comprises the steps:
1) Radix Astragali adds 8 times of amount 30% ethanol with alcohol reflux twice at every turn, extracts 4 hours, and merge extractive liquid, filters, and relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
2) Folium Ginkgo adds 8 times of amount 75% ethanol with alcohol reflux twice at every turn, extracts 3 hours, and merge extractive liquid, filters, and relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
3) Radix Notoginseng, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae three flavor medicines, decocte with water twice, add the water of 10 times of amounts the first time, decocted 2 hours; Add for the second time the water of 8 times of amounts, decocted collecting decoction 1 hour; Filter, relative density was the clear paste of 1.10-1.13 when filtrating was concentrated into 70 ℃, added ethanol and made that containing the alcohol amount reaches 65%; Left standstill 24 hours, and filtered, relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
4) merge above-mentioned clear paste, be spray dried to dried cream powder.
2. the method for distilling of the described Chinese medicine composition of claim 1 is characterized in that, this method for distilling comprises the steps:
1) Radix Astragali adds 8 times of amount 30% ethanol with alcohol reflux twice at every turn, extracts 4 hours, and merge extractive liquid, filters, and relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
2) Folium Ginkgo adds 8 times of amount 75% ethanol with alcohol reflux twice at every turn, extracts 3 hours, and merge extractive liquid, filters, and relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
3) Radix Notoginseng, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae three flavor medicines, decocte with water twice, add the water of 10 times of amounts the first time, decocted 2 hours; Add for the second time the water of 8 times of amounts, decocted collecting decoction 1 hour; Filter, relative density was the clear paste of 1.10-1.13 when filtrating was concentrated into 70 ℃, added ethanol and made that containing the alcohol amount reaches 65%; Left standstill 24 hours, and filtered, relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
4) merge above-mentioned clear paste, be spray dried to dried cream powder.
3. contain the preparation that right requires 1 or 2 described Chinese medicine compositions, it is characterized in that said preparation is by this Chinese medicine composition and pharmaceutically acceptable carrier or diluent.
4. preparation according to claim 3; It is characterized in that said pharmaceutically acceptable carrier or diluent are selected from one or more in lactose, starch, dextrin, mannitol, sucrose, hydroxypropyl methylcellulose, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, magnesium stearate or the Pulvis Talci.
5. preparation according to claim 3 is characterized in that, said preparation is solid preparation or liquid preparation.
6. preparation according to claim 5 is characterized in that, said solid preparation is tablet, capsule, granule, drop pill.
7. preparation according to claim 5 is characterized in that, said liquid preparation is injection, mixture or oral liquid.
8. preparation according to claim 5 is characterized in that, said preparation is a granule.
9. a method for preparing the described preparation of claim 3 is characterized in that, this method may further comprise the steps:
1) Radix Astragali is used the alcohol reflux secondary, adds 8 times of amount 30% ethanol at every turn, extracts 4 hours, and merge extractive liquid, filters, and relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
2) Folium Ginkgo adds 8 times of amount 75% ethanol with alcohol reflux twice at every turn, extracts 3 hours, and merge extractive liquid, filters, and relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
3) Radix Notoginseng, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae three flavor medicines, decocte with water twice, add the water of 10 times of amounts the first time, decocted 2 hours; Add for the second time the water of 8 times of amounts, decocted collecting decoction 1 hour; Filter, relative density was the clear paste of 1.10-1.13 when filtrating was concentrated into 70 ℃, added ethanol and made that containing the alcohol amount reaches 65%; Left standstill 24 hours, and filtered, relative density was the clear paste of 1.13-1.15 when filtrating was concentrated into 70 ℃;
4) merge above-mentioned clear paste, be spray dried to dried cream powder;
5) get dried cream powder and excipient or mixing diluents pharmaceutically commonly used, process preparation with conventional method for preparing.
10. the application of the described Chinese medicine composition of claim 1 in the medicine of preparation treatment stroke in convalescent stage.
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| CN103735878B (en) * | 2014-01-14 | 2015-09-30 | 山东省立医院 | A kind of medicine for stroke at convalescence rehabilitation |
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| CN101780140A (en) * | 2009-01-20 | 2010-07-21 | 北京因科瑞斯医药科技有限公司 | Drug for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN101953918A (en) * | 2010-10-13 | 2011-01-26 | 南方医科大学 | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases |
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| CN101780140A (en) * | 2009-01-20 | 2010-07-21 | 北京因科瑞斯医药科技有限公司 | Drug for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN101953918A (en) * | 2010-10-13 | 2011-01-26 | 南方医科大学 | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases |
Non-Patent Citations (1)
| Title |
|---|
| 刘德泉.冠心病的中药运用规律探讨.《光明中医》.1999,14-16. * |
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