CN102101018B - Cascade high-pressure electro-osmosis pump - Google Patents
Cascade high-pressure electro-osmosis pump Download PDFInfo
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- CN102101018B CN102101018B CN 201110038728 CN201110038728A CN102101018B CN 102101018 B CN102101018 B CN 102101018B CN 201110038728 CN201110038728 CN 201110038728 CN 201110038728 A CN201110038728 A CN 201110038728A CN 102101018 B CN102101018 B CN 102101018B
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- capillary channel
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Abstract
The invention relates to the technical field of chemical analysis, and discloses a cascade high-pressure electro-osmosis pump. The electro-osmosis pump comprises a cationic capillary channel, an anionic capillary channel, couplers, a high-voltage power supply, a working medium container and a platinum electrode; the cationic capillary channel and the anionic capillary channel are alternately connected to form the three-stage or multi-stage cascade electro-osmosis pump through the couplers; the positive voltage of the high-voltage power supply is applied to two ends of the cationic capillary channel, and the negative voltage of the high-voltage power supply is applied to two ends of the anionic capillary channel; and the capillary channels are tubular or groove-shaped channels made of rigid insulating materials. The electro-osmosis pump has the advantages that: automatic switching of electric field direction and effective improvement of output pressure are realized in a mode of alternately connecting the cationic capillary channel and the anionic capillary channel, the usage number of the electric field couplers is furthest reduced, and the system of the pump is simplified.
Description
Technical field
The present invention relates to the chemical analysis technology field, be specifically related to a kind of micrometeor high-pressure pump---Cascade high-pressure electro-osmosis pump, can be used for capillary or receive the systems such as upgrade liquid chromatogram, capillary ion chromatography.
Background technology
Capillary/receive upgrade liquid chromatogram (CLC) or capillary ion chromatography (CIC) be efficient with it, save solvent, be easy to become one of analytical technology that is concerned by people most in recent years with the advantage such as mass spectrum (MS) coupling.High pressure pump is one of core component of capillary liquid chromatography system, and its function is that mobile phase or leacheate are transported to the splitter system, makes sample finish separation process.Because capillary liquid chromatography system range of flow commonly used is μ L/min level, and the conventional mechanical infusion pump is difficult to accurately carry microlitre and μ L/min with down-off because of little seepage of check valve and dynamic seal (packing).Electroosmotic pump (EOP) is a kind of novel Micropump that utilizes EOF to realize liquid driven, and its feature is that output pressure is high, and uninterrupted and direction change and can easily realize by changing electric field level and direction.When other conditions remained unchanged, the output pressure that improves electroosmotic pump can apply voltage by raising electric-field intensity or raising and realize.And the voltage that the electroosmotic pump pump housing commonly used need to apply is generally several kilovolts to volts up to ten thousand.This high pressure is unfavorable for operating personnel's safety, especially under the larger environment of humidity ratio.But low-voltage and high output pressure become conflict.Solution is used the cascade electroosmotic pump exactly, namely with the series connection of the multistage pump of similar multiplier, is equivalent to a plurality of pump housings series connection and need not to improve and apply voltage.
The cascade electroosmotic pump is proposed first by people such as Takamura, is to make up an open pipe formula cascade electroosmotic pump at glass-chip, and every grade of pump pump housing connects single fat pipe two parts after by 10 parallel narrow passages and forms.The two ends that forward voltage is applied to narrow passage produce the EOF of a forward, and the backward voltage that applies an equivalence at the fat pipe two ends produces a reverse EOF.Because the total EOF that produces in narrow passage district EOF on the fat pipe, therefore, be the forward EOF from the clean EOF of every grade of electroosmotic pump output.In like manner, the pressure of every grade of electroosmotic pump output is the forward output pressure, and this cascade electroosmotic pump can be realized the multiplication of output pressure.
For overcoming the low latent defect of above-mentioned open pipe cascade electroosmotic pump output pressure, the people such as Guan have proposed a kind of cascade electroosmotic pump based on packed column, and its every primary pump comprises capillary packed column and open pipe capillary two parts.Capillary packed column and open pipe capillary adopt identical material, and its difference is: in the former (capillary packed column) filler is arranged, latter's (open pipe capillary) is hollow; The two ends that forward voltage is applied to capillary packed column produce the EOF of a forward, and the backward voltage that applies an equivalence at open pipe capillary two ends can produce a reverse EOF.Use this open pipe capillary to be only used for switching direction of an electric field, but this design has obviously increased the complexity of system, simultaneously, the EOF that it produces has been offset the EOF that the part capillary packed column produces.
Though it is ingenious that above-mentioned two kinds of cascade electroosmotic pumps design, and has a common defective, that is: the oppositely existence that divides of electroosmotic pump body.For example, fat pipe and open pipe capillary have been adopted respectively in the above-mentioned design, the increase of using these pump housings to be only used for switching direction of an electric field and being unprofitable to EOF or output pressure, still, the quantity that increases coupler (or being referred to as jointing) can increase the complexity of system.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of Cascade high-pressure electro-osmosis pump is provided, can realize naturally switching of direction of an electric field, reduced to greatest extent the use amount of coupler, the Effective Raise output pressure.
For achieving the above object, the technical scheme taked of the present invention is:
A kind of Cascade high-pressure electro-osmosis pump, contain cationic capillary channel, anionic capillary channel, coupler and high voltage source, it is characterized in that, alternately connect three grades or the multi-stage cascade electroosmotic pump that makes up for utilizing cationic capillary channel, anionic capillary channel by coupler; The forward voltage of high voltage source is applied to cationic capillary channel two ends and the negative voltage of high voltage source is applied to anionic capillary channel two ends.
The cationic capillary channel of described three-stage cascade electroosmotic pump and anionic capillary channel alternately being connected to by coupler: the first cationic capillary channel is the first order pump of three-stage cascade electroosmotic pump, the second cationic capillary channel is the third level pump of three-stage cascade electroosmotic pump, and two passage two ends all apply forward voltage; The anionic capillary channel is the second level pump of three-stage cascade electroosmotic pump, and its two ends apply negative voltage; After applying electric field, the first cationic capillary channel and the second cationic capillary channel all produce the EOF from the positive pole to the negative pole, and produce the EOF from the negative pole to the positive pole in the anionic capillary channel.
Described cationic capillary channel or anionic capillary channel are that effective internal diameter is the passage of the rigid insulation material construction of 1～750 μ m, and passage is tubular-type or groove-shaped; The particle diameter of filler particles is 100 nm～10 μ m or the monoblock type filler that makes up by the in-situ polymerization mode in the passage.
Described cationic capillary channel comprises that surface functional group is that strong cation type capillary channel and the surface functional group of sulfonic group-SO3-is phosphate-PO
3-Or carboxylic acid group-COO
-Or-SiO
-Weak cation type capillary channel.
Described anionic capillary channel comprises that surface functional group is quaternary amine base-R
4N
+Reinforcing yin essence ionic capillary channel and surface functional group be tertiary amine-R
3N or secondary amine-R
2The weak anionic type capillary channel of N.
Described coupler is stainless steel two-way or stainless steel threeway.
The good effect of a kind of Cascade high-pressure electro-osmosis pump of the present invention is:
Utilize cation exchange integral post, anion exchange integral post alternately to connect and be built into three grades or multi-stage cascade electroosmotic pump, after applying electric field, cationic capillary channel produces the EOF from the positive pole to the negative pole, and produces the EOF from the negative pole to the positive pole in the anionic capillary channel; Owing to not backflowing in the system, therefore total output pressure approximates the summation of triplex, namely, total output pressure of three grades or multi-stage cascade electroosmotic pump equals cationic capillary channel and anionic capillary channel output pressure sum, can execute the multiplication that realizes output pressure under the alive condition need not to improve by this mode.
Description of drawings
Fig. 1 is the structural representation of a kind of Cascade high-pressure electro-osmosis pump of the present invention (three-stage cascade electroosmotic pump);
Fig. 2 is the design sketch of a kind of Cascade high-pressure electro-osmosis pump of the present invention (three-stage cascade electroosmotic pump);
Label among the figure is respectively:
1, the first cationic capillary channel; 2, anionic capillary channel;
31, the first coupler; 32, the second coupler;
33, the 3rd coupler; 4, the second cationic capillary channel;
5, output capillary channel; 6, high voltage source;
7, working medium container; 8, platinum electrode.
The specific embodiment
Provide the specific embodiment of a kind of Cascade high-pressure electro-osmosis pump of the present invention below in conjunction with accompanying drawing, still, enforcement of the present invention is not limited to following embodiment.
Referring to accompanying drawing 1.A kind of Cascade high-pressure electro-osmosis pump, be the three-stage cascade electroosmotic pump, contain the first cationic capillary channel 1, anionic capillary channel 2, coupler, the second cationic capillary channel 4, output capillary channel 5, high voltage source 6, working medium container 7 and platinum electrode 8.Get the cationic capillary channel of several sections certain-lengths (such as 10～20 cm) and the anionic capillary channel of several sections certain-lengths (such as 10～20 cm), cationic capillary channel is alternately linked to each other with the anionic capillary channel.As making up the three-stage cascade electroosmotic pump, its structure is: the positive pole of high voltage source 6 is linked to each other with platinum electrode 8, coupler 32 respectively; The negative pole of high voltage source 6 links to each other with coupler 33 with coupler 31 respectively; Thereby an end of the first cationic capillary channel 1 is inserted in the working medium container 7 is connected with platinum electrode 8; The other end of the first cationic capillary channel 1 is connected with an end of anionic capillary channel 2 by the first coupler 31; One end of the second cationic capillary channel 4 is connected with the other end of anionic capillary channel 2 by the second coupler 32; The other end of the second cationic capillary channel 4 is connected with output capillary channel 5 by the 3rd coupler 33.
The first order pump that the first cationic capillary channel 1 is the three-stage cascade electroosmotic pump, the third level pump that the second cationic capillary channel 4 is the three-stage cascade electroosmotic pump.The forward voltage of high voltage source 6 and platinum electrode 8 and working medium container 7 are connected to positive pole, and an end that links to each other with working medium container 7 of the first cationic capillary channel 1 is for anodal, and the other end that links to each other with the first coupler 31 is negative pole; Anionic capillary channel 2 is the second level pumps for the three-stage cascade electroosmotic pump, and the negative voltage of high voltage source 6 is applied to the two ends of anionic capillary channel 2: the first coupler 31 and the second coupler 32 are respectively as negative pole and positive pole; What the second cationic capillary channel 4 two ends applied is positive field, and an end that links to each other with the second coupler 32 is for anodal, and with an end of the 3rd coupler 33 be negative pole.After applying electric field, the first cationic capillary channel 1 and the second cationic capillary channel 4 all produce the EOF from the positive pole to the negative pole, and the EOF of anionic capillary channel 2 interior generations from the negative pole to the positive pole.
It is the passage of the rigid insulation material construction of 250 μ m that described cationic capillary channel or anionic capillary channel 2 adopt effective internal diameter, and passage is tubular-type or groove-shaped; The particle diameter of filler particles is that the particle diameter that 100 nm～10 μ m(adopt usually is 3 μ m or 5 μ m in the passage) or the monoblock type filler that makes up by the in-situ polymerization mode.
Described cationic capillary channel can adopt the strong cation type, and (surface functional group is sulfonic group-SO
3-) or weak cation type capillary channel (surface functional group is phosphate-PO
3-Or carboxylic acid group-COO
-Or-SiO
-).Described anionic capillary channel 2 can adopt the reinforcing yin essence ionic, and (surface functional group is quaternary amine base-R
4N
+) or weak anionic type capillary channel (surface functional group is tertiary amine-R
3N or secondary amine-R
2N).Described coupler adopts stainless steel two-way or stainless steel threeway.High voltage source 6, working medium container 7 and platinum electrode 8 can adopt existing product, without specific (special) requirements.
If make up level Four or more multistage cascade electroosmotic pump, can realize with the progression that the anionic capillary channel alternately links to each other by increasing cationic capillary channel.
Referring to accompanying drawing 2.Adopt above-mentioned three-stage cascade electroosmotic pump, when applying voltage and be 4 kV, its total output pressure approximates the single output pressure sum of triplex.
Claims (5)
1. Cascade high-pressure electro-osmosis pump, contain cationic capillary channel, anionic capillary channel, coupler and high voltage source, it is characterized in that, alternately connect three grades of making up or level Four or multi-stage cascade electroosmotic pump more for utilizing cationic capillary channel, anionic capillary channel by coupler; The forward voltage of high voltage source is applied to cationic capillary channel two ends and the negative voltage of high voltage source is applied to anionic capillary channel two ends; Alternately being connected to of the three-stage cascade electroosmotic pump that described alternately connection makes up: the first cationic capillary channel is the first order pump of three-stage cascade electroosmotic pump, the second cationic capillary channel is the third level pump of three-stage cascade electroosmotic pump, and two passage two ends all apply forward voltage; The anionic capillary channel is the second level pump of three-stage cascade electroosmotic pump, and its two ends apply negative voltage; After applying electric field, the first cationic capillary channel and the second cationic capillary channel all produce the EOF from the positive pole to the negative pole, and the EOF of generation from the negative pole to the positive pole in the anionic capillary channel, make up level Four or more multistage cascade electroosmotic pump, realize with the progression that the anionic capillary channel alternately links to each other by increasing cationic capillary channel.
2. a kind of Cascade high-pressure electro-osmosis pump according to claim 1, it is characterized in that, described cationic capillary channel or anionic capillary channel are that effective internal diameter is the passage of the rigid insulation material construction of 250 μ m, and passage is tubular-type or groove-shaped; The particle diameter of filler particles is 100 nm～10 μ m or the monoblock type filler that makes up by the in-situ polymerization mode in the passage.
3. a kind of Cascade high-pressure electro-osmosis pump according to claim 2 is characterized in that, described cationic capillary channel comprises that surface functional group is sulfonic group-SO
3 -Strong cation type capillary channel and surface functional group be phosphate-PO
3 -Or carboxylic acid group-COO
-Or-SiO
-Weak cation type capillary channel.
4. a kind of Cascade high-pressure electro-osmosis pump according to claim 2, it is characterized in that, described anionic capillary channel comprises that surface functional group is the reinforcing yin essence ionic capillary channel of quaternary amine base and the weak anionic type capillary channel that surface functional group is tertiary amine groups or secondary amine.
5. a kind of Cascade high-pressure electro-osmosis pump according to claim 1 is characterized in that, described coupler is stainless steel two-way or stainless steel threeway.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110038728 CN102101018B (en) | 2011-02-16 | 2011-02-16 | Cascade high-pressure electro-osmosis pump |
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|---|---|---|---|
| CN 201110038728 CN102101018B (en) | 2011-02-16 | 2011-02-16 | Cascade high-pressure electro-osmosis pump |
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| CN102101018A CN102101018A (en) | 2011-06-22 |
| CN102101018B true CN102101018B (en) | 2013-02-27 |
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| CN 201110038728 Expired - Fee Related CN102101018B (en) | 2011-02-16 | 2011-02-16 | Cascade high-pressure electro-osmosis pump |
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| CN103665098B (en) * | 2012-09-20 | 2015-08-05 | 中国科学院大连化学物理研究所 | Diphasic column membrane protein microreactor and application thereof |
| CN103708408A (en) * | 2013-12-17 | 2014-04-09 | 北京工业大学 | Micro-nano fluid driving device |
| GB201408472D0 (en) | 2014-05-13 | 2014-06-25 | Osmotex Ag | Electroosmotic membrane |
| CN110339878B (en) * | 2019-07-08 | 2021-01-19 | 西安交通大学 | Device and method for controlling volume flow of power law fluid in microchannel |
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| US6019882A (en) * | 1997-06-25 | 2000-02-01 | Sandia Corporation | Electrokinetic high pressure hydraulic system |
| US6805783B2 (en) * | 2000-12-13 | 2004-10-19 | Toyo Technologies, Inc. | Method for manipulating a solution using a ferroelectric electro-osmotic pump |
| CN1249899C (en) * | 2001-10-09 | 2006-04-05 | 厦门大学 | Mini type electroosmosis pump |
| CN1226074C (en) * | 2002-11-15 | 2005-11-09 | 中国科学院大连化学物理研究所 | Superhigh pressure microflux electricosmotic pump |
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Granted publication date: 20130227 Termination date: 20140216 |