CN102058870B - Medicine for treating rheumatic and rheumatoid arthralgia, stroke and hemiplegia and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament for treating rheumatism, rheumatoid arthritis and apoplexy hemiplegia, which is prepared from the raw material medicaments of codonopsis pilosula, angelica, astragalus, prepared rehmannia root, ligusticum wallichii, bighead atractylodes rhizome, poria cocos and the like according to a certain weight ratio.

Description

A kind of medicine of treating rheumatic and rheumatoid arthralgia apoplectic hemiplegia and preparation method thereof

Technical field

The present invention relates to a kind of medicine of treating rheumatism, rheumatoid arthrosis disease and apoplectic hemiplegia, belong to the field of Chinese medicines.

Background technology

Rheumatism, rheumatoid disease are one of a kind of commonly encountered diseases, frequently-occurring disease, in motherland's medical science, belong to " arthromyodynia " category, and its cause of disease all is because human body constitution is weak mostly, insufficiency of vital energy and blood; Or overwork, the skin pore is loose, the Wei Bugu of battalion, and exopathogen is taken advantage of a weak point; Multiple abscess meridians, muscle, joint cause coagulation of QI-blood, blocking barrier, stagnation of QI and blood may bring about pain and arthralgia occurs; Movable unfavorable, not thorough like prevention and treatment, it can invade tissue or organs such as heart, joint, skin, serous coat, blood vessel, brain, lung, kidney and corpus ciliare choroideae, and is the most remarkable with heart and joint damage; And the tendency of outbreak is repeatedly arranged, suffer damage repeatedly, cause the cardiac valve adhesion like heart; Cicatrix increases, and will form chronic rheumatic heart disease, the serious health that is threatening human body.

Western medical treatment is with bigcatkin willow acid supplement and non-hormone preparation, with eliminate the inflammation, and alleviating pain; The control active rheumatism; When acute or chronic rheumatoid, quasi-rheumatoid arthritis acute attack, adopt antibiotic control streptococcal infection and cooperate the physical therapy acupuncture-moxibustion and topical remedy's sealing waits Comprehensive Treatment, but these medicines are part alleviation and the symptomatic treatment that rheumatism, rheumatoid arthrosis disease are carried out; Can't solve the recurrence problem of rheumatism, rheumatoid disease; And drug side effect is big, and stomach and digestive tract are all had stimulation, can cause gastrorrhagia, gastric perforation, digestive tract ulcer when serious.

Summary of the invention

So there is great demand in the Chinese medicine preparation that people better treat rheumatism, rheumatoid arthrosis disease to curative effect; Up to now; Also do not find any relevant report about pharmaceutical composition of the present invention, the present invention is through research repeatedly, and the repeated validation through animal and clinical trial; Finally work out the treatment rheumatism of better curative effect, the endo-medicine of rheumatoid disease, thereby accomplished the present invention.

The object of the invention just provides the Chinese medicine medicine of a kind of effective treatment rheumatism, rheumatoid arthrosis disease and apoplectic hemiplegia.

Another object of the present invention has just provided the method for preparing of this Chinese medicine medicine.

Medicament selection Radix Codonopsis of the present invention, Radix Angelicae Sinensis, the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Cortex Cinnamomi, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Cibotii, Caulis Spatholobi, Radix Dipsaci, the Cortex Eucommiae, Herba Taxilli, Radix Angelicae Pubescentis, Rhizoma Polygonati, Arillus Longan, Radix Achyranthis Bidentatae, Cortex Magnoliae Officinalis(processed with ginger), the Radix Aucklandiae, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Caulis Polygoni Multiflori, Fructus Amomi make up, and with these drug regimens, make each medicine effect produce synergism; Thereby can effectively treat the recurrence of rheumatism, rheumatoid arthrosis disease, wherein select for use Radix Codonopsis to be because its nature and flavor are sweet, flat; Start with, the meridian of Foot-TAI YIN edema caused by disorder of QI, invigorating middle warmer is arranged, QI invigorating; The function of promoting the production of body fluid is controlled weakness of the spleen and stomach, deficiency of both QI and blood; Fatigue and lack of strength, lack of appetite, thirsty; Chronic diarrhea, proctoptosis.Selecting Radix Angelicae Sinensis for use is that temperature is gone into the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation because of the sweet suffering of its nature and flavor; Control menoxenia, amenorrhea stomachache ， mass in the abdomen knot gathers, metrorrhagia, and headache due to deficiency of blood, dizzy; Flaccidity syndrome and arthralgia syndrome, the dryness of the intestine dyschezia, heavy after the bloody dysentery, ulcer sores, injury from falling down.Select for use the Radix Astragali to be because its nature and flavor are sweet, warm, go into lung, spleen channel, tonifying Qi and lifting yang is arranged, benefit is defended consolidating superficial resistance, inducing diuresis to remove edema; The function of holder skin ulcer granulation promoting, it is weak to control the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis; The metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and bursts for a long time and does not hold back; Blood deficiency and yellow complexion, interior hot water is thirsty, chronic nephritis proteinuria, diabetes.Select for use Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor is gone into liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.Select for use Rhizoma Chuanxiong to be because its nature and flavor are hot, temperature is gone into liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, and the function of promoting blood circulation and stopping pain is controlled air-cooled headache and is revolved dizzyly, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Selecting the Rhizoma Atractylodis Macrocephalae for use is that temperature is gone into spleen, stomach warp, and spleen reinforcing is arranged because of its property bitter but sweet flavor, stomach reinforcing, and the function of dampness diuretic is controlled deficient QI of the spleen and stomach, anorexia, the asthenia weak breath, deficiency-distension, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Select for use Poria to be because its property slightly sweet flavor is flat, go into the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming is controlled dysuria, the edema distension, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select for use Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, go into spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription is processed usefulness, controls weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus ， Jing Epilepsy; Give birth to usefulness, control laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Selecting Cortex Cinnamomi for use is that heat is gone into kidney, spleen, urinary bladder channel because of its property acrid-sweet flavor, the complement sun is arranged, warming the spleen and stomach, removing accumulated cold; The function of promoting blood circulation is controlled decline of the fire from the gate of life, the cold extremities faint pulse, and the YANG-depletion collapse, stomachache is had loose bowels, the colic of cold type renal mass; Chills and pain of the waist and kness, amenorrhea and mass in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.Select for use Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, go into lung, spleen, kidney channel, spleen invigorating is arranged, tonifying the lung is reinforced the kidney, and the function that benefit is clear is controlled diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease is quenched one's thirst, seminal emission, leukorrhagia, frequent micturition.Select for use Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor is gone into the heart, Liver Channel, and blood circulation promoting and blood stasis dispelling is arranged, calming heart and tranquilizing mind, and evacuation of pus, the analgesic function is controlled angina pectoris, menoxenia, dysmenorrhea, amenorrhea, metrorrhagia leukorrhagia ， mass in the abdomen gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select for use Flos Carthami to be because its nature and flavor are hot, temperature is gone into the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged, and blood stasis removing analgesic function is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Selecting Rhizoma Cibotii for use is that temperature is gone into liver, kidney channel, and invigorating the liver and kidney is arranged because of its property bitter but sweet flavor, removes rheumatism, strong waist foot, and the function in sharp joint is controlled the back ache, the gonalgia flaccidity of the lower limbs, the cold general arthralgia that shows, mistake is drowned, frequent micturition, seminal emission, white stagnating.Selecting Caulis Spatholobi for use is because its property bitter but sweet flavor, and temperature is gone into the heart, spleen two warps, have invigorate blood circulation, the function of Shujin, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select Radix Dipsaci for use, different name dragon bean, Rhizoma seu Herba Elatostematis stewardii, Radix Dipsaci are that tepor is gone into liver, kidney channel, and invigorating the liver and kidney is arranged because of its nature and flavor toil; Reuniting the fractured tendons and bones, the function of blood circulation regulating is controlled aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia; Leukorrhagia, seminal emission, traumatic injury, incised wound, anal fistula, the carbuncle skin ulcer is swollen.Selecting the Cortex Eucommiae for use is that temperature is gone into liver, kidney channel, and invigorating the liver and kidney is arranged because of the sweet little suffering of its nature and flavor, bone and muscle strengthening, and antiabortive function is controlled the spinal column ache, foot and knee flaccidity, surplus the rushing down of urinating, uncontrolled urination is itched, and vaginal bleeding during pregnancy is desired to fall, hypertension.Select for use Herba Taxilli to be because its nature and flavor are bitter, sweet, flat, go into the heart, kidney two warps, invigorating the liver and kidney is arranged, bone and muscle strengthening removes rheumatism, the meridian dredging, the function that beneficial blood is antiabortive is controlled soreness of waist and knee joint, a little less than the muscles and bones flaccidity, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia.Select for use Radix Angelicae Pubescentis to be because its nature and flavor are arduous, temperature is gone into kidney, urinary bladder channel, dispels the wind, and win and wet, cold expelling, the analgesic function is controlled anemofrigid-damp arthralgia, soreness of waist and knee joint, trick spasm and pain, chronic tracheitis, headache, toothache.Select for use Rhizoma Polygonati to be because its nature and flavor are sweet, flat, go into spleen, lung, kidney channel, invigorating the spleen and replenishing QI is arranged, the profit cardiopulmonary, the function of bone and muscle strengthening is controlled deficient cold and heat, the pulmonary tuberculosis hemoptysis, the empty lack of appetite of body after being ill, muscles and bones is weak, rheumatalgia, wind favus disease.Select for use Arillus Longan to be because it is sweet in flavor and warm in property, the GUIXIN spleen channel has heart-spleen boosting, fills blood, the function of calming the nerves, and it is thin and weak to control asthenia, insomnia forgetfulness, palpitation with fear, palpitation with a distress feeling.Select for use Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, go into liver, kidney channel, give birth to and use dissipating blood stasis blood, subduing inflammation is controlled gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury.Ripely use invigorating the liver and kidney, bone and muscle strengthening is controlled waist kneecap pain, spasm of the limbs, flaccidity syndrome and arthralgia syndrome.Select for use Cortex Magnoliae Officinalis(processed with ginger) to be because its nature and flavor toil temperature is returned spleen, stomach, large intestine channel, the function of warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant is arranged, control breast abdomen feeling of fullness distending pain, the regurgitation vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, the cold-damp dysentery.Select for use the Radix Aucklandiae to be because its nature and flavor are arduous, temperature is gone into lung, liver, spleen channel, and promoting the circulation of QI to relieve pain are arranged, and the function of warming middle-JIAO for easing the stomach is controlled the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, and dysentery tenesmus, colic of cold type are had loose bowels in vomiting.Select for use Rhizoma Zingiberis to be because its nature and flavor are hot, heat is gone into spleen, stomach, lung meridian, and there have warming middle-JIAO to pursue to be cold, and the function that recuperating depleted YANG is promoted blood circulation is controlled trusted subordinate's cold type of pain, vomit and diarrhoea, and the cold extremities faint pulse, cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, yang deficiency is told, nosebleed, hematochezia.Select for use Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, go into spleen, stomach warp, there is removing food stagnancy to stagnate, the function of strengthening the spleen and stomach is controlled the food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition is quenched one's thirst, and omits sore throat tonsillitis, ulcerative gingivitis aphtha.Select for use Caulis Polygoni Multiflori to be because its property sweet and slightly bitter taste is flat, go into the heart, Liver Channel, nourish heart, calm the nerves, collateral dredging, the function of dispeling the wind is controlled insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.Select for use Fructus Amomi to be because its nature and flavor are hot, temperature is gone into spleen, stomach warp, has in the circulation of qi promoting accent, and stomach function regulating, the function of being amusing are controlled the stomachache painful abdominal mass and expanded anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.

The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and the consumption of each component all has curative effect preferably in following weight range.

Radix Codonopsis 35-50 gram Radix Angelicae Sinensis 25-35 gram Radixs Astragali 50-70 grams

Radix Rehmanniae Preparata 35-50 gram Rhizoma Chuanxiongs 25-35 gram Rhizoma Atractylodis Macrocephalaes 35-50 grams

Poria 50-70 gram Radix Glycyrrhizaes 25-35 gram Cortex Cinnamomis 35-50 grams

Rhizoma Dioscoreae 40-60 gram Radix Salviae Miltiorrhizaes 40-60 gram Flos Carthamis 25-35 grams

Rhizoma Cibotii 40-60 gram Caulis Spatholobis 40-60 gram Radix Dipsacis 40-60 grams

The Cortex Eucommiae 40-60 gram Herba Taxillis 40-60 gram Radix Angelicae Pubescentiss 25-35 grams

Rhizoma Polygonati 35-50 gram Arillus Longans 35-50 gram Radix Achyranthis Bidentataes 50-70 grams

Cortex Magnoliae Officinalis(processed with ginger) 40-50 gram Radix Aucklandiae 35-50 gram Rhizoma Zingiberiss 35-50 grams

Endothelium Corneum Gigeriae Galli 40-60 gram Caulis Polygoni Multiflori 40-60 gram Fructus Amomis 35-50 grams

Preferable amount does

The Radix Codonopsis 40 gram Radix Angelicae Sinensis 30 gram Radixs Astragali 60 grams

The Radix Rehmanniae Preparata 40 gram Rhizoma Chuanxiongs 30 gram Rhizoma Atractylodis Macrocephalaes 40 grams

Poria 60 gram Radix Glycyrrhizaes 30 gram Cortex Cinnamomis 40 grams

Rhizoma Dioscoreae 50 gram Radix Salviae Miltiorrhizaes 50 gram Flos Carthamis 30 grams

Rhizoma Cibotii 50 gram Caulis Spatholobis 50 gram Radix Dipsacis 50 grams

The Cortex Eucommiae 50 gram Herba Taxillis 50 gram Radix Angelicae Pubescentiss 30 grams

Rhizoma Polygonati 40 gram Arillus Longans 40 gram Radix Achyranthis Bidentataes 60 grams

The Cortex Magnoliae Officinalis(processed with ginger) 50 gram Radix Aucklandiae 40 gram Rhizoma Zingiberiss 40 grams

Endothelium Corneum Gigeriae Galli 50 gram Caulis Polygoni Multiflori 50 gram Fructus Amomis 40 grams

The method for preparing of medicine of the present invention is following

One, get the raw materials ready:

1, Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;

2, Radix Angelicae Sinensis: choose decontamination, clean, moistening dries in the air to inside and outside humidity when suitable slightly, and section is dried;

3, the Radix Astragali: get crude drug, remove impurity, big or small stepping is cleaned, and runs through, and cuts sheet, drying, and sieve removes chip;

4, Radix Rehmanniae Preparata: get Radix Rehmanniae Preparata and put and forge in the pot, adorn eighty per cant fullly, cover one pot above, two pots of joints are used the yellow mud front cover; Top weight uses literary composition to open fire and forges to being attached to the blank sheet of paper that covers on the bottom of a pan to show coke yellow for degree, blocks vent; After cooling, take out, or Radix Rehmanniae Preparata is put in the pot directly a parch to black also can;

5, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;

6, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out, run through, section is dried;

7, Poria: be soaked in water, clean, pull out, vexed after, cut into slices, dry;

8, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when eighty per cant passes through, pull out, run through section, dry;

9, Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes; Or scrape off rough bark, with the eliminating cold for resuscitation water infiltration for a moment, section is dried;

10, Rhizoma Dioscoreae: choose decontamination, be soaked in water and pull out and dry in the air slightly for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;

11, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through the back section, dry;

12, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

13, Rhizoma Cibotii: get sand and put the interior stir-fry of pot to easily, add and choose clean Rhizoma Cibotii, stir-fry with high heat is to heaving and apparent buff, and taking-up screens out sand, after wind dries in the air, hits or the yellow floss hair of scraping;

14, Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;

15, Radix Dipsaci: get the Radix Dipsaci sheet and go in the pot and fry to little Jiao's degree of being with slow fire;

16, the Cortex Eucommiae: add certain amount of boiling water with Sal earlier and dissolve, get Cortex Eucommiae piece or strand, make with saline and fully mix absorption, put then in the pot, using slow fire to fry to little has focal spot to be degree, and taking-up is dried;

17, Herba Taxilli: former medicinal washing is clean, runs through cutting, dries;

18, Radix Angelicae Pubescentis: choose decontamination, separately size is individual, cleans, and runs through the back section, drying;

19, Rhizoma Polygonati: clean earth, slightly profit is cut into slices, and dries;

20, Arillus Longan: pluck during fruit maturation, peel off peel, get its aril, dry;

21, Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting is dried;

22, Cortex Magnoliae Officinalis(processed with ginger): get the Rhizoma Zingiberis Recens section and fry in shallow oil soup, it is well-done altogether to add clean thick servant and ginger decoction, treats that soup exhausts, and takes out, and section is in time dried, and 100 jin of every Cortex Magnoliae Officinalis are with 10 jin in Rhizoma Zingiberis Recens;

23, the Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, moistening made soft in 12-24 hours, and section is dried;

24, Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices behind the moistening or dice, dry;

25, Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;

26, Caulis Polygoni Multiflori: clear water is cleaned, and soaks slightly, pulls out, and after running through, cutting is dried;

27, Fructus Amomi: remove impurity and shell, smash to pieces.

Two, preparation

(1) Radix Codonopsis, Radix Angelicae Sinensis, the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Cortex Cinnamomi, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Cibotii, Caulis Spatholobi, Radix Dipsaci, the Cortex Eucommiae, Herba Taxilli, Radix Angelicae Pubescentis, Rhizoma Polygonati, Arillus Longan, Radix Achyranthis Bidentatae, Cortex Magnoliae Officinalis(processed with ginger), the Radix Aucklandiae, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Caulis Polygoni Multiflori, the Fructus Amomi of said weight are put into the container of boiling medicine and add 3000 milliliters in water, soaked 2 hours.

(2) decoct to boiling reuse slow fire boiling 2 hours with very hot oven.

(3) filter medicinal residues, get for the first time 500 milliliters of medicinal liquids.

(4) last medicinal residues are added clear water again and decocted 2 hours for 2500 milliliters, cross 500 milliliters of the leaching medicinal liquids second time.

Medicine of the present invention has and dispels the wind, dampness, and collateral dredging is invigorated blood circulation, invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating is dialled the function of taking poison and growing muscle due, is used to treat the arthralgia that rheumatism, rheumatoid disease cause, the joint distortion, the apoplectic hemiplegia good effect, cure rate is high.

The specific embodiment

Below come further to set forth the beneficial effect of medicine according to the invention, these Test Example to comprise that the animal toxicity test of medicine of the present invention and clinical observation test through Test Example.

The animal toxicity test of [Test Example 1] medicine of the present invention

Test method:

Get 20 of new zealand rabbits, the male and female dual-purpose, body weight 2.0-2.5kg is divided into two groups; Every group 10, wherein one group is the normal amount toxicity test, and another group is the super quantity toxicity test, and the normal amount group is every 10ml/kg; The every 20ml/kg of excess group, administering mode are the administration by gavage administration, every day twice, serve on seven days; Observe the administration reaction after perfusion every day, result of the test shows two groups of rabbit diet, and movable normal, medicine does not have bad toxic and side effects.

The clinical observation material of [Test Example 2] medicine of the present invention

1, physical data

Accept out-patient's 98 examples for medical treatment, wherein male 71 examples, women 27 examples, 16-20 years old 3 age example, 21-30 years old 16 example, 31-40 years old 21 example, 41-50 years old 26 example, 32 examples more than 50 years old.

2, diagnostic criteria

Acute rheumatic arthralgia: clinical manifestation is that the unexpected trick of patient is weak, arthralgia, and the extremity limitation of activity, double knee joint is red and swollen, and the patient expresses one's feelings painful spiritual poor.

Chronic rheumatic arthralgia: the patient has the rheumatism medical history, aching pain in should and back, and leg joint is stiff, two kneecap arthroncuss, the little redness and swelling of joints distortion of extremity can not be walked, the less patient suffering face, the overcast and rainy state of an illness increases the weight of.

Apoplectic hemiplegia: single limb arm of patient and lower limb body LOM, arm turns up, facial hemiparalysis, lower extremity paralysis can not be walked, and can't take care of oneself.

3, Therapeutic Method

Decocting liquid: by the component drug of measuring the said treatment rheumatism of foot, rheumatoid disease and apoplectic hemiplegia, put into the container of boiling medicine and add 3000 milliliters of immersions of water 2 hours, very hot oven boils, slow fire boiling 2 hours; Cross 500 milliliters in leaching first juice, last medicinal residues are added 2500 milliliters in clear water again, decocted 2 hours; Cross 500 milliliters of the leaching second juice medicinal liquids, every day, secondary was early obeyed first juice; Obey second juice evening, and 20 days is a course of treatment, serve on 2-3 courses of treatment.

4, efficacy assessment standard

Produce effects: rheumatic arthralgia patient whole body joint recovers normal, and pain disappears, the movable walking freely, and the apoplectic hemiplegia patient is limb functional recover up and down, takes care of oneself, and observes 1 year no recidivist.

Take a turn for the better: rheumatic arthralgia patient two kneecap joints detumescence, the little joint function recovery of extremity, apoplectic hemiplegia progressively takes a turn for the better, and patient can walk separately by turning battle.

Invalid: as not reach improvement standard person.

5, therapeutic outcome:

In the treatment of two courses of treatment, with Drug therapy acute rheumatic arthralgia patient 36 examples of the present invention, produce effects 31 examples as a result, 4 examples that take a turn for the better do not have 1 example of treatment, and obvious effective rate is 86.11%, transfers 11.11% to well, and total effective rate is 97.22%; In the treatment of three courses of treatment, with Drug therapy chronic rheumatic arthralgia patient 50 examples of the present invention, produce effects 42 examples as a result, 5 examples that take a turn for the better, invalid 3 examples, obvious effective rate is 84%, and improvement rate is 10%, and total effective rate is 94%; In the treatment of three courses of treatment, with these bright Drug therapy apoplectic hemiplegia patient 12 examples, produce effects 7 examples as a result, 3 examples that take a turn for the better, invalid 2 examples, obvious effective rate is 58.33%, and improvement rate is 25%, and total effective rate is 83.33%.

Claims (3)

1. medicine of treating rheumatic and rheumatoid arthralgia apoplectic hemiplegia, it is characterized in that: it is to be processed by the crude drug in the following weight scope:

Radix Codonopsis 35-50 gram Radix Angelicae Sinensis 25-35 gram Radixs Astragali 50-70 grams

Radix Rehmanniae Preparata 35-50 gram Rhizoma Chuanxiongs 25-35 gram Rhizoma Atractylodis Macrocephalaes 35-50 grams

Poria 50-70 gram Radix Glycyrrhizaes 25-35 gram Cortex Cinnamomis 35-50 grams

Rhizoma Dioscoreae 40-60 gram Radix Salviae Miltiorrhizaes 40-60 gram Flos Carthamis 25-35 grams

Rhizoma Cibotii 40-60 gram Caulis Spatholobis 40-60 gram Radix Dipsacis 40-60 grams

The Cortex Eucommiae 40-60 gram Herba Taxillis 40-60 gram Radix Angelicae Pubescentiss 25-35 grams

Rhizoma Polygonati 35-50 gram Arillus Longans 35-50 gram Radix Achyranthis Bidentataes 50-70 grams

Cortex Magnoliae Officinalis(processed with ginger) 40-50 gram Radix Aucklandiae 35-50 gram Rhizoma Zingiberiss 35-50 grams

Endothelium Corneum Gigeriae Galli 40-60 gram Caulis Polygoni Multiflori 40-60 gram Fructus Amomis 35-50 grams.

2. the medicine of treatment rheumatic and rheumatoid arthralgia apoplectic hemiplegia according to claim 1, wherein the consumption of each crude drug is:

The Radix Codonopsis 40 gram Radix Angelicae Sinensis 30 gram Radixs Astragali 60 grams

The Radix Rehmanniae Preparata 40 gram Rhizoma Chuanxiongs 30 gram Rhizoma Atractylodis Macrocephalaes 40 grams

Poria 60 gram Radix Glycyrrhizaes 30 gram Cortex Cinnamomis 40 grams

Rhizoma Dioscoreae 50 gram Radix Salviae Miltiorrhizaes 50 gram Flos Carthamis 30 grams

Rhizoma Cibotii 50 gram Caulis Spatholobis 50 gram Radix Dipsacis 50 grams

The Cortex Eucommiae 50 gram Herba Taxillis 50 gram Radix Angelicae Pubescentiss 30 grams

Rhizoma Polygonati 40 gram Arillus Longans 40 gram Radix Achyranthis Bidentataes 60 grams

The Cortex Magnoliae Officinalis(processed with ginger) 50 gram Radix Aucklandiae 40 gram Rhizoma Zingiberiss 40 grams

Endothelium Corneum Gigeriae Galli 50 gram Caulis Polygoni Multiflori 50 gram Fructus Amomis 40 grams.

3. according to the method for preparing of claim 1 or 2 said medicines, it is characterized in that: it is processed by the following step:

(1) gets the raw materials ready

(1) Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;

(2) Radix Angelicae Sinensis: choose decontamination, clean, moistening dries in the air to inside and outside humidity when suitable slightly, and section is dried;

(3) Radix Astragali: get crude drug, remove impurity, big or small stepping is cleaned, and runs through, and cuts sheet, drying, and sieve removes chip;

(4) Radix Rehmanniae Preparata: get Radix Rehmanniae Preparata and put and forge in the pot, adorn eighty per cant fullly, cover one pot above, two pots of joints are used the yellow mud front cover; Top weight uses literary composition to open fire and forges to being attached to the blank sheet of paper that covers on the bottom of a pan to show coke yellow for degree, blocks vent; After cooling, take out, or Radix Rehmanniae Preparata is put in the pot directly a parch to black also can;

(5) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;

(6) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out, run through, section is dried;

(7) Poria: be soaked in water, clean, pull out, vexed after, cut into slices, dry;

(8) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water when eighty per cant passes through, pull out, run through section, dry;

(9) Cortex Cinnamomi: choose clean impurity, scrape off rough bark, the time spent smashes; Or scrape off rough bark, with the eliminating cold for resuscitation water infiltration for a moment, section is dried;

(10) Rhizoma Dioscoreae: choose decontamination, be soaked in water and pull out and dry in the air slightly for degree to the Rhizoma Dioscoreae central part is softening, section is dried or is dried;

(11) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through the back section, dry;

(12) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

(13) Rhizoma Cibotii: get sand and put the interior stir-fry of pot to easily, add and choose clean Rhizoma Cibotii, stir-fry with high heat is to heaving and apparent buff, and taking-up screens out sand, after wind dries in the air, hits or the yellow floss hair of scraping;

(14) Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;

(15) Radix Dipsaci: get the Radix Dipsaci sheet and go in the pot and fry to little Jiao's degree of being with slow fire;

(16) Cortex Eucommiae: add certain amount of boiling water with Sal earlier and dissolve, get Cortex Eucommiae piece or strand, make with saline and fully mix absorption, put then in the pot, using slow fire to fry to little has focal spot to be degree, and taking-up is dried;

(17) Herba Taxilli: former medicinal washing is clean, runs through cutting, dries;

(18) Radix Angelicae Pubescentis: choose decontamination, separately size is individual, cleans, and runs through the back section, drying;

(19) Rhizoma Polygonati: clean earth, slightly profit is cut into slices, and dries;

(20) Arillus Longan: pluck during fruit maturation, peel off peel, get its aril, dry;

(21) Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting is dried;

(22) Cortex Magnoliae Officinalis(processed with ginger): get the Rhizoma Zingiberis Recens section and fry in shallow oil soup, it is well-done altogether to add clean thick servant and ginger decoction, treats that soup exhausts, and takes out, and section is in time dried, and 100 jin of every Cortex Magnoliae Officinalis are with 10 jin in Rhizoma Zingiberis Recens;

(23) Radix Aucklandiae: crude drug in whole put in the clear water clean, pull out, moistening made soft in 12-24 hours, and section is dried;

(24) Rhizoma Zingiberis: choose clean impurity, be soaked in water 3-6 hours, pull out, cut into slices behind the moistening or dice, dry;

(25) Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;

(26) Caulis Polygoni Multiflori: clear water is cleaned, and soaks slightly, pulls out, and after running through, cutting is dried;

(27) Fructus Amomi: remove impurity and shell, smash to pieces;

(2) preparation

(1) Radix Codonopsis, Radix Angelicae Sinensis, the Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Cortex Cinnamomi, Rhizoma Dioscoreae, Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Cibotii, Caulis Spatholobi, Radix Dipsaci, the Cortex Eucommiae, Herba Taxilli, Radix Angelicae Pubescentis, Rhizoma Polygonati, Arillus Longan, Radix Achyranthis Bidentatae, Cortex Magnoliae Officinalis(processed with ginger), the Radix Aucklandiae, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Caulis Polygoni Multiflori, the Fructus Amomi of said weight are put into the container of boiling medicine and add 3000 milliliters in water, soaked 2 hours;

(2) decoct to boiling reuse slow fire boiling 2 hours with very hot oven;

(3) filter medicinal residues, get for the first time 500 milliliters of medicinal liquids;

(4) last medicinal residues are added clear water again and decocted 2 hours for 2500 milliliters, cross 500 milliliters of the leaching medicinal liquids second time.