CN101687048A - 可水解的聚合fmoc-连接体 - Google Patents
可水解的聚合fmoc-连接体 Download PDFInfo
- Publication number
- CN101687048A CN101687048A CN200880021877A CN200880021877A CN101687048A CN 101687048 A CN101687048 A CN 101687048A CN 200880021877 A CN200880021877 A CN 200880021877A CN 200880021877 A CN200880021877 A CN 200880021877A CN 101687048 A CN101687048 A CN 101687048A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- chemical compound
- group
- psa
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/164—Unsaturated ethers containing six-membered aromatic rings
- C07C43/168—Unsaturated ethers containing six-membered aromatic rings containing six-membered aromatic rings and other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
Claims (14)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93716907P | 2007-06-26 | 2007-06-26 | |
US60/937,169 | 2007-06-26 | ||
US12326308P | 2008-04-07 | 2008-04-07 | |
US61/123,263 | 2008-04-07 | ||
PCT/EP2008/005155 WO2009000522A1 (en) | 2007-06-26 | 2008-06-25 | Hydrolysable polymeric fmoc-linker |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101687048A true CN101687048A (zh) | 2010-03-31 |
CN101687048B CN101687048B (zh) | 2013-02-27 |
Family
ID=39855055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008800218771A Active CN101687048B (zh) | 2007-06-26 | 2008-06-25 | 可水解的聚合fmoc-连接体 |
Country Status (16)
Country | Link |
---|---|
US (3) | US7700551B2 (zh) |
EP (1) | EP2173383B1 (zh) |
JP (1) | JP5622569B2 (zh) |
KR (1) | KR101654375B1 (zh) |
CN (1) | CN101687048B (zh) |
AR (1) | AR067627A1 (zh) |
AU (1) | AU2008267360B2 (zh) |
BR (1) | BRPI0813772A2 (zh) |
CA (1) | CA2690554C (zh) |
DK (1) | DK2173383T3 (zh) |
ES (1) | ES2644453T3 (zh) |
HK (1) | HK1142828A1 (zh) |
MX (1) | MX2009013682A (zh) |
NZ (1) | NZ582669A (zh) |
TW (1) | TWI569810B (zh) |
WO (1) | WO2009000522A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103933575A (zh) * | 2013-01-23 | 2014-07-23 | 上海新理念生物医药科技有限公司 | 一种三齿型连接子及其应用 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2532369B1 (en) | 2006-12-15 | 2017-11-01 | Baxalta GmbH | Factor VIIa-(poly)sialic acid conjugate having prolonged in vivo half-life |
CA2690554C (en) * | 2007-06-26 | 2016-08-16 | Baxter International Inc. | Hydrolysable polymeric fmoc - linker |
US9795683B2 (en) | 2009-07-27 | 2017-10-24 | Lipoxen Technologies Limited | Glycopolysialylation of non-blood coagulation proteins |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
PT2459224T (pt) | 2009-07-27 | 2016-09-05 | Baxalta Inc | Conjugados proteicos para coagulação sanguínea |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
KR101832937B1 (ko) | 2009-07-27 | 2018-02-28 | 박스알타 인코퍼레이티드 | 혈액 응고 단백질 복합체 |
BR112013015898A2 (pt) | 2010-12-22 | 2018-06-26 | Baxter International Inc. | derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada. |
KR20140053991A (ko) | 2011-07-18 | 2014-05-08 | 아츠 바이올로직스 에이/에스 | 장기간 작용하는 황체 형성 호르몬 (lh) 화합물 |
EP2846822A2 (en) | 2012-05-11 | 2015-03-18 | Prorec Bio AB | Method for diagnosis and treatment of prolactin associated disorders |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6680295B1 (en) * | 1994-09-22 | 2004-01-20 | The Administrators Of The Tulane Educational Fund | Method and pharmaceutical composition for prevention and treatment of brain damage |
US6368814B1 (en) * | 2000-12-22 | 2002-04-09 | Roche Diagnostics Corporation | Tricyclic antidepressant derivatives and immunoassay |
ES2512499T3 (es) * | 2003-04-08 | 2014-10-24 | Yeda Research And Development Co., Ltd. | Fármacos pegilados reversibles |
WO2005014655A2 (en) * | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US7691826B2 (en) * | 2003-08-12 | 2010-04-06 | Lipoxen Technologies Limited | Polysialic acid derivatives |
JP4942014B2 (ja) * | 2004-09-14 | 2012-05-30 | 独立行政法人産業技術総合研究所 | O−結合型糖アミノ酸 |
JP5022231B2 (ja) * | 2004-12-27 | 2012-09-12 | バクスター・インターナショナル・インコーポレイテッド | ポリマー−フォンビルブラント因子結合体 |
EP1896082B1 (en) * | 2005-06-16 | 2012-12-26 | Nektar Therapeutics | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
EP2532369B1 (en) * | 2006-12-15 | 2017-11-01 | Baxalta GmbH | Factor VIIa-(poly)sialic acid conjugate having prolonged in vivo half-life |
AU2007340382B2 (en) * | 2006-12-27 | 2013-06-27 | Nektar Therapeutics | Von Willebrand Factor- and Factor VIII-polymer conjugates having a releasable linkage |
CA2690554C (en) * | 2007-06-26 | 2016-08-16 | Baxter International Inc. | Hydrolysable polymeric fmoc - linker |
-
2008
- 2008-06-25 CA CA2690554A patent/CA2690554C/en active Active
- 2008-06-25 CN CN2008800218771A patent/CN101687048B/zh active Active
- 2008-06-25 EP EP08759334.9A patent/EP2173383B1/en active Active
- 2008-06-25 TW TW097123653A patent/TWI569810B/zh active
- 2008-06-25 MX MX2009013682A patent/MX2009013682A/es active IP Right Grant
- 2008-06-25 AR ARP080102744A patent/AR067627A1/es unknown
- 2008-06-25 US US12/215,218 patent/US7700551B2/en active Active
- 2008-06-25 KR KR1020107001646A patent/KR101654375B1/ko active IP Right Grant
- 2008-06-25 JP JP2010513749A patent/JP5622569B2/ja active Active
- 2008-06-25 AU AU2008267360A patent/AU2008267360B2/en active Active
- 2008-06-25 WO PCT/EP2008/005155 patent/WO2009000522A1/en active Application Filing
- 2008-06-25 NZ NZ582669A patent/NZ582669A/en unknown
- 2008-06-25 DK DK08759334.9T patent/DK2173383T3/en active
- 2008-06-25 ES ES08759334.9T patent/ES2644453T3/es active Active
- 2008-06-25 BR BRPI0813772-2A2A patent/BRPI0813772A2/pt not_active Application Discontinuation
-
2010
- 2010-01-15 US US12/688,461 patent/US8445544B2/en active Active
- 2010-01-18 US US12/689,096 patent/US20100121028A1/en not_active Abandoned
- 2010-09-30 HK HK10109423.6A patent/HK1142828A1/xx unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103933575A (zh) * | 2013-01-23 | 2014-07-23 | 上海新理念生物医药科技有限公司 | 一种三齿型连接子及其应用 |
WO2014114207A1 (zh) * | 2013-01-23 | 2014-07-31 | 上海新理念生物医药科技有限公司 | 一种三齿型连接子及其应用 |
Also Published As
Publication number | Publication date |
---|---|
WO2009000522A1 (en) | 2008-12-31 |
KR101654375B1 (ko) | 2016-09-05 |
KR20100039854A (ko) | 2010-04-16 |
ES2644453T3 (es) | 2017-11-29 |
NZ582669A (en) | 2011-07-29 |
MX2009013682A (es) | 2010-08-31 |
US20100121028A1 (en) | 2010-05-13 |
EP2173383A1 (en) | 2010-04-14 |
AR067627A1 (es) | 2009-10-21 |
JP2010531371A (ja) | 2010-09-24 |
US7700551B2 (en) | 2010-04-20 |
CN101687048B (zh) | 2013-02-27 |
US8445544B2 (en) | 2013-05-21 |
EP2173383B1 (en) | 2017-08-09 |
AU2008267360B2 (en) | 2013-09-12 |
DK2173383T3 (en) | 2017-09-25 |
HK1142828A1 (en) | 2010-12-17 |
CA2690554C (en) | 2016-08-16 |
TW200908996A (en) | 2009-03-01 |
JP5622569B2 (ja) | 2014-11-12 |
TWI569810B (zh) | 2017-02-11 |
AU2008267360A1 (en) | 2008-12-31 |
US20090005542A1 (en) | 2009-01-01 |
BRPI0813772A2 (pt) | 2014-12-30 |
US20100121034A1 (en) | 2010-05-13 |
CA2690554A1 (en) | 2008-12-31 |
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REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1142828 Country of ref document: HK |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160729 Address after: Illinois, USA Patentee after: Hundred deep company Patentee after: Hundred deep limited liability company Address before: Illinois, USA Patentee before: Baxter International Inc. Patentee before: Bakst Helth Co., Ltd. |
|
TR01 | Transfer of patent right |
Effective date of registration: 20210707 Address after: Osaka Patentee after: TAKEDA PHARMACEUTICAL Co.,Ltd. Address before: Illinois, USA Patentee before: Baishen Co. Patentee before: BAXALTA GmbH |
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TR01 | Transfer of patent right |