CN101669920A - Strong anti-oxidation DHA microcapsule and preparation method thereof - Google Patents
Strong anti-oxidation DHA microcapsule and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a strong anti-oxidation DHA microcapsule. The microcapsule comprises the following components in percentage by weight: 10 to 30 percent of DHA fish oil, 0.02 to 0.2 percent ofantioxidant, 10 to 60 percent of wall material, and 5 to 30 percent of auxiliary wall material 5. The invention also relates to a method for preparing the strong anti-oxidation DHA microcapsule. On the basis of the prior process, the microcapsule is prepared by adding the antioxidant to oil phase and water phase respectively and performing emulsification, high-pressure homogenization, improved spray granulation and cold-air boiling-drying. The newly added antioxidant can produce better anti-oxidation effects and greatly improve the oxidation stability of the DHA microcapsule so as to prolongthe shelf life of products, and the improved spray granulation and the cold-air boiling-drying process can increase the yield of the DHA microcapsule. The DHA microcapsule can be used in the fields ofmedicines, foods, beverages and the like.
Description
Technical field
The present invention relates to a kind of preparation and preparation method thereof, especially relate to a kind of strong anti-oxidation DHA microcapsule and preparation method thereof.
Background technology
DHA (docosahexenoic acid) is the important lipid components of cell membrane, retina, brain, to the formation of cranial nerve, safeguard that the normal function of cranial nerve, the decline that delays cranial nerve play an important role; Metabolite 20 carbonic acid derivatives of EPA can effectively be regulated the synthetic of bioactive substances such as arachidonic acid, prostaglandin, leukotriene, thereby have the illness of control cardiovascular and cerebrovascular disease, inflammation, reproductive system and the function of enhancing human body self immunity etc.
But DHA and EPA are very easy to the oxidation by airborne oxygen institute, bring certain trouble for their reprocessing and preservation.DHA fish oil is carried out the parcel of microcapsule technology, can strengthen product stability greatly, prolong its product shelf life.Present stage, microcapsule technology is existing certain application aspect the fish oil goods, for example publication number is the preparation method of the DHA fish-oil capsule mentioned of the application for a patent for invention file of CN1927050A, but the more weak shortcoming of fish oil micro-capsule ubiquity non-oxidizability that prior art makes, it is not fine making its product stability, thereby has limited its product shelf life.Simultaneously, existing main spray drying technology is difficult to control and to cause the loss of some raw materials to cause waste for the yield of microcapsule.
Summary of the invention
Technical problem to be solved by this invention provides a kind of strong anti-oxidation DHA microcapsule and preparation method, by with common emulsifying such as DHA fish oil, antioxidant, capsule material, emulsifying agent, homogenizing, mist projection granulating is made strong anti-oxidation DHA microcapsule through the cold wind airpillow-dry, new prescription significantly improves the product stability and the productive rate of microcapsule, can be directly used in fields such as medicine, food, beverage.
The composition of a kind of strong anti-oxidation DHA microcapsule that the present invention relates to is: the percentage by weight between each component is a DHA fish oil 10%～30%, antioxidant 0.02%～0.2%, wall material 10%～60%, supplementary wall material 5%～30%.Be preferably DHA fish oil 20%～30%, antioxidant 0.1%～0.2%, wall material 30%～60%, supplementary wall material 10%～30%.
In the said components of the present invention:
1, DHA (docosahexenoic acid) is a Main Ingredients and Appearance in the DHA fish oil, and DHA (docosahexenoic acid) and EPA (weight percent content of eicosapentaenoic acid) ratio are greater than 7.
2, add antioxidant in the capsule material solution to one or both of vitamin C, tea polyphenols.
3, add antioxidant in the core solution to one or both of vitamin E, lecithin, Butylated hydroxyanisole.
4, the capsule material is with a kind of of octenyl succinate starch, gelatin, arabic gum or more than 2 kinds.
5, auxiliary capsule material is with a kind of of sucrose ester, dextrin, sodium caseinate or more than 2 kinds.
Preparation method
1), preparation oil-phase solution: above-mentioned DHA fish oil and antioxidant are pressed the proportioning mixing and stirring.
2), preparation aqueous phase solution: it is even that above-mentioned wall material, supplementary wall and antioxidant are mixed in the water dispersed with stirring by proportioning.
3), preparation emulsion: oil-phase solution is slowly added aqueous phase solution high-speed stirred emulsifying certain hour.
4), high pressure homogenize: with above-mentioned emulsion at high pressure homogenize under 40～50Mpa pressure more than 3 times.
5), mist projection granulating: the emulsion behind the above-mentioned homogenizing is added in the centrifugal spray dryer, and inlet temperature is 150～190 ℃, and leaving air temp is 70～80 ℃, and the shower nozzle rotating speed is under 2～30,000 conditions of changeing, and carries out mist projection granulating.
6), cold wind airpillow-dry: the microcapsule after the above-mentioned pelletize is carried out the cold wind airpillow-dry at a certain temperature, make strong oxidized form DHA microcapsule.
The strong anti-oxidation DHA microcapsule that the present invention makes can be widely used in fields such as medicine, food, beverage as additive.Because adopting to prepare mutually at profit respectively, this invention adds antioxidant in the solution, therefore its product non-oxidizability of DHA microcapsule that makes with this method has remarkable enhancing, the product shelf life prolongs greatly, adopt cold wind airpillow-dry technology simultaneously, obviously improved the yield of microcapsule and reduced raw-material waste.
Description of drawings
Fig. 1 is the antioxygenic property comparison diagram between each microcapsule of the present invention;
The specific embodiment
Specifically introduce the specific embodiment of the present invention below in conjunction with accompanying drawing.
Embodiment 1
DHA fish oil 15%
Gelatin 60%
Vitamin C 0.1%
Lecithin 0.1%
Dextrin 24.8%
Pure water is an amount of
Preparation method
1), preparation oil-phase solution: DHA fish oil and vitamin C are pressed the proportioning mixing and stirring.
2), preparation aqueous phase solution: it is even that gelatin, dextrin and lecithin are mixed in the water dispersed with stirring by proportioning.
3), preparation emulsion: oil-phase solution is slowly added aqueous phase solution high-speed stirred emulsifying certain hour.
4), high pressure homogenize: with above-mentioned emulsion at high pressure homogenize under 40～50Mpa pressure more than 3 times.
5), mist projection granulating: the emulsion behind the above-mentioned homogenizing is added in the centrifugal spray dryer, and inlet temperature is 150～190 ℃, and leaving air temp is 70～80 ℃, and the shower nozzle rotating speed is under 2～30,000 the condition, to carry out mist projection granulating.
6), cold wind airpillow-dry: the microcapsule after the above-mentioned pelletize is carried out the cold wind airpillow-dry at a certain temperature, make microcapsule.
Embodiment 2
DHA fish oil 20%
Octenyl succinate starch 50%
Vitamin C 0.1%
Vitamin E 0.1%
Sodium caseinate 29.8%
Pure water is an amount of
Preparation method
1), preparation oil-phase solution: DHA fish oil and vitamin C are pressed the proportioning mixing and stirring.
2), preparation aqueous phase solution: it is even that octenyl succinate starch, sodium caseinate and vitamin E are mixed in the water dispersed with stirring by proportioning.
3), preparation emulsion: oil-phase solution is slowly added aqueous phase solution high-speed stirred emulsifying certain hour.
4), high pressure homogenize: with above-mentioned emulsion at high pressure homogenize under 40～50Mpa pressure more than 3 times.
5), mist projection granulating: the emulsion behind the above-mentioned homogenizing is added in the centrifugal spray dryer, and inlet temperature is 150～190 ℃, and leaving air temp is 70～80 ℃, and the shower nozzle rotating speed is under 2～30,000 conditions of changeing, and carries out mist projection granulating.
6), cold wind airpillow-dry: the microcapsule after the above-mentioned pelletize is carried out the cold wind airpillow-dry at a certain temperature, make microcapsule.
Embodiment 3
DHA fish oil 25%
Octenyl succinate starch 45%
Tea polyphenols 0.05%
Lecithin 0.15%
Sodium caseinate 29.8%
Pure water is an amount of
Preparation method
1), preparation oil-phase solution: DHA fish oil and tea polyphenols are pressed the proportioning mixing and stirring.
2), preparation aqueous phase solution: it is even that octenyl succinate starch, sodium caseinate and lecithin are mixed in the water dispersed with stirring by proportioning.
3), preparation emulsion: oil-phase solution is slowly added aqueous phase solution high-speed stirred emulsifying certain hour.
4), high pressure homogenize: with above-mentioned emulsion at high pressure homogenize under 40～50Mpa pressure more than 3 times.
5), mist projection granulating: the emulsion behind the above-mentioned homogenizing is added in the centrifugal spray dryer, and inlet temperature is 150～190 ℃, and leaving air temp is 70～80 ℃, and the shower nozzle rotating speed is under 2～30,000 conditions of changeing, and carries out mist projection granulating.
6), cold wind airpillow-dry: the microcapsule after the above-mentioned pelletize is carried out the cold wind airpillow-dry at a certain temperature, make microcapsule.
Embodiment 4
DHA fish oil 25%
Gelatin 40%
Tea polyphenols 0.05%
Lecithin 0.05%
Sucrose ester 34.9%
Pure water is an amount of
Preparation method
1), preparation oil-phase solution: DHA fish oil and tea polyphenols are pressed the proportioning mixing and stirring.
2), preparation aqueous phase solution: it is even that gelatin, sucrose ester and lecithin are mixed in the water dispersed with stirring by proportioning.
3), preparation emulsion: oil-phase solution is slowly added aqueous phase solution high-speed stirred emulsifying certain hour.
4), high pressure homogenize: with above-mentioned emulsion at high pressure homogenize under 40～50Mpa pressure more than 3 times.
5), mist projection granulating: the emulsion behind the above-mentioned homogenizing is added in the centrifugal spray dryer, and inlet temperature is 150～190 ℃, and leaving air temp is 70～80 ℃, and the shower nozzle rotating speed is under 2～30,000 conditions of changeing, and carries out mist projection granulating.
6), cold wind airpillow-dry: the microcapsule after the above-mentioned pelletize is carried out the cold wind airpillow-dry at a certain temperature, make microcapsule.
Embodiment 5
DHA fish oil 30%
Arabic gum 50%
Tea polyphenols 0.05%
Vitamin E 0.15%
Dextrin 29.9%
Pure water is an amount of
Preparation method
1), preparation oil-phase solution: DHA fish oil and tea polyphenols are pressed the proportioning mixing and stirring.
2), preparation aqueous phase solution: it is even that arabic gum, dextrin and vitamin E are mixed in the water dispersed with stirring by proportioning.
3), preparation emulsion: oil-phase solution is slowly added aqueous phase solution high-speed stirred emulsifying certain hour.
4), high pressure homogenize: with above-mentioned emulsion at high pressure homogenize under 40～50Mpa pressure more than 3 times.
5), mist projection granulating: the emulsion behind the above-mentioned homogenizing is added in the centrifugal spray dryer, and inlet temperature is 150～190 ℃, and leaving air temp is 70～80 ℃, and the shower nozzle rotating speed is under 2～30,000 conditions of changeing, and carries out mist projection granulating.
6), cold wind airpillow-dry: the microcapsule after the above-mentioned pelletize is carried out the cold wind airpillow-dry at a certain temperature, make microcapsule.
Experimental result
| Bulk density (g/ml) | Moisture | Ash | Productive rate | Wrap oily rate | DHA content | |
| Embodiment 1 | ??4.8 | ??1.9％ | ??1.3％ | ??96.8％ | ??98.3％ | ??14.3％ |
| Embodiment 2 | ??4.9 | ??1.8％ | ??1.1％ | ??98.3％ | ??99.4％ | ??16.5％ |
| Embodiment 3 | ??4.7 | ??2.1％ | ??1.4％ | ??97.4％ | ??97.4％ | ??23.8％ |
| Embodiment 4 | ??4.7 | ??1.9％ | ??1.3％ | ??97.2％ | ??98.7％ | ??22.9％ |
| Embodiment 5 | ??4.8 | ??1.9％ | ??1.2％ | ??97.8％ | ??99.2％ | ??26.7％ |
| Common microcapsule | ??4.4 | ??2.2％ | ??1.9％ | ??93.5％ | ??97.6％ | ??17.3％ |
Stable content and non-oxidizability experiment
1, strong anti-oxidation DHA microcapsule and the common DHA microcapsule with embodiment 1,2,3,4,5 preparation gained is positioned in the accelerated test case, and 60 ℃ of temperature, humidity are 75% storage 10 days, respectively at the situation of change of investigating product DHA content on the the 5th, 10 day.
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Common microcapsule | |
| Former content | ??14.30％ | ??16.50％ | ??23.80％ | ??22.90％ | ??26.70％ | ??17.30％ |
| 5 days | ??13.90％ | ??16.40％ | ??22.70％ | ??21.60％ | ??26.80％ | ??15.20％ |
| 10 days | ??13.60％ | ??15.90％ | ??22.30％ | ??21.70％ | ??25.40％ | ??14.60％ |
| Content reduces percentage ratio | ??4.90％ | ??3.64％ | ??6.30％ | ??5.24％ | ??4.87％ | ??15.61％ |
The microcapsule stable content that makes under the technology of preparing of the present invention has as can be seen from the table proved absolutely the superiority of invention technology apparently higher than common microcapsule.
2, strong anti-oxidation DHA microcapsule and the common DHA microcapsule with embodiment 1,2,3,4,5 preparation gained is positioned in the accelerated test case, 45 ℃ of temperature, humidity is 30% storage 30 days, respectively at the situation of change of investigating the product peroxide value on the the 5th, 10,15,20,30 day.(accompanying drawing 1 as a result)
As seen from the figure, the rising speed of common microcapsule peroxide value is apparently higher than the rising speed of the microcapsule peroxide value of the present invention's preparation under the accelerated tests condition, and the present invention has obviously improved DHA fish oil microcapsule antioxygenic property as can be known.
Though more than elaborated the present invention in conjunction with specific embodiments, described specific embodiment just illustrates, but not is used to limit this content and scope.
Protection scope of the present invention should be as the criterion with the record of claims.According to accompanying drawing of the present invention and detailed description, conspicuous variations and modifications are also in the spirit and scope of claim of the present invention concerning being familiar with those skilled in the art.
Claims (9)
1, a kind of strong anti-oxidation DHA microcapsule, it is characterized in that: the percentage by weight between each component is: DHA fish oil 10%～30%, antioxidant 0.02%～0.2%, wall material 10%～60%, supplementary wall material 5%～30%.
2, a kind of strong anti-oxidation DHA microcapsule according to claim 1, it is characterized in that: the percentage by weight between each component is: DHA fish oil 20%～30%, antioxidant 0.1%～0.2%, wall material 30%～60%, supplementary wall material 10%～30%.
3, a kind of strong anti-oxidation DHA microcapsule according to claim 1 and 2, it is characterized in that: DHA in the DHA fish oil (docosahexenoic acid) is a Main Ingredients and Appearance, and DHA (docosahexenoic acid) and EPA (weight percent content of eicosapentaenoic acid) ratio are greater than 7.
4, a kind of strong anti-oxidation DHA microcapsule according to claim 1 and 2 is characterized in that: antioxidant is a kind of of vitamin C, vitamin E, tea polyphenols, lecithin, Butylated hydroxyanisole or more than 2 kinds.
5, a kind of strong anti-oxidation DHA microcapsule according to claim 1 and 2 is characterized in that: the wall material is a kind of of octenyl succinate starch, gelatin, arabic gum or more than 2 kinds.
6, a kind of strong anti-oxidation DHA microcapsule according to claim 1 and 2 is characterized in that: the supplementary wall material is a kind of of sucrose ester, dextrin, sodium caseinate or more than 2 kinds.
7, a kind of preparation the steps include: as claim 1 or 2 arbitrary described a kind of strong anti-oxidation DHA microcapsule preparation technology methods
1), described DHA fish oil and antioxidant are prepared the gained oil-phase solution by the proportioning mixing and stirring;
2), described wall material, supplementary wall material and antioxidant are mixed in dispersed with stirring uniform preparation gained aqueous phase solution in the water by proportioning;
3), then described oil-phase solution is slowly prepared gained emulsion behind the described aqueous phase solution high-speed stirred emulsifying certain hour of adding;
4), more described emulsion is obtained high pressure homogenize at high pressure homogenize under 40～50Mpa pressure more than 3 times;
5), the emulsion behind the described homogenizing adds in the centrifugal spray dryer and carries out mist projection granulating, is prepared into microcapsule, reaction condition is: inlet temperature is 150～190 ℃, leaving air temp is 70～80 ℃, the shower nozzle rotating speed is 2～30,000 commentaries on classics;
6), at last the microcapsule behind the described mist projection granulating is carried out the cold wind airpillow-dry at a certain temperature, make strong anti-oxidation DHA microcapsule.
8, preparation technology's method of a kind of strong anti-oxidation DHA microcapsule according to claim 7 is characterized in that: in encapsulation process, adopt respectively and carry out the emulsifying technology of preparing at oil phase, the different antioxidant of aqueous phase interpolation.
9, preparation technology's method of a kind of strong anti-oxidation DHA microcapsule according to claim 7 is characterized in that: the microcapsule behind the mist projection granulating is carried out the cold wind airpillow-dry under 70～90 ℃.
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