CN101658680B - Medical environment-friendly sterilization ultrasound coupling agent and preparation method thereof - Google Patents
Medical environment-friendly sterilization ultrasound coupling agent and preparation method thereof Download PDFInfo
- Publication number
- CN101658680B CN101658680B CN2009103081423A CN200910308142A CN101658680B CN 101658680 B CN101658680 B CN 101658680B CN 2009103081423 A CN2009103081423 A CN 2009103081423A CN 200910308142 A CN200910308142 A CN 200910308142A CN 101658680 B CN101658680 B CN 101658680B
- Authority
- CN
- China
- Prior art keywords
- parts
- coupling agent
- water
- add
- ultrasound coupling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a medical environment-friendly sterilization ultrasound coupling agent and a preparation method thereof, wherein the ultrasound coupling agent comprises the components based on the parts by weight: 5-30 parts of corn starch, 2-2.5 parts of 30% of hydrogen peroxide, 0.04-0.08 part of ferrous sulphate, 2-2.5 parts of sodium hydroxide, 1.2-1.5 parts of sodium borate, 0.10-2.00 parts of iodine, 3.00-20.00 parts of fatty alcohol-polyoxyethylene ether, 0-1.00 part of potassium iodide, 0-1.00 part of potassium iodate, 1.00 part of glycerin, 0.20 part of citric acid and 60-78 parts of water. When being used for ultrasonic detection, the ultrasound coupling agent ensures the detection image to be clear and the cross infection risk which is possibly caused by the ultrasonic detection to be little, does not swell and corrode an ultrasonic probe, can be degraded so as to be free from environmental pollution, and has the characteristic of strong environmental conservation property. The ultrasound coupling agent prepared by the method has the advantages of wide source of raw materials, good environmental conservation property, low price, simple preparation working procedures and low equipment investment.
Description
Technical field
The present invention relates to a kind of reagent that is used for ultrasound examination, particularly a kind of medical environment-friendly sterilization ultrasound coupling agent and preparation method thereof.
Background technology
The function of ultrasonic coupling agent is to be filled between ultrasonic probe and the human body skin, gets rid of this spatial air, makes hyperacoustic conduction not be subjected to air influence, thereby obtains good detection effect.The disclosed ultrasonic coupling agent of JP2008249519 contains silicon-containing polymer (silicon-containing polymer); The disclosed ultrasonic coupling agent of US6432069 uses polyvinylpyrrolidone (Polyvinylpyrrolidone), and these synthetic material prices are expensive, are difficult to biodegradation, have some environmental problems.CN1062468, CN1065400 and CN1171271 adopt biodegradable thickening agents such as thickening agent CD-68, sodium alginate, sodium carboxymethyl cellulose, gelatin and agar, and still, these cost of material are higher.
CN1087016 discloses " preparation method of medical ultrasonic coupling agent ", and this couplant does not have the function of sterilization.The sterilization of ultrasonic probe is a difficult problem always, and its reason has: disinfectant must not make plastics and the rubber corrosion or the swelling of ultrasonic probe; Can not carry out disinfection with infusion method; Interval between the tested patient has only about 1min, need be in 1min kill bacteria, mycete and virus simultaneously.CN101219223 " has medical ultrasonic coupling agent of disinfecting and sterilizing functions and preparation method thereof " and discloses, and makes thickening agent with the crosslinked polypropylene acid resin, and 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers are made the ultrasonic coupling agent that disinfectant is made; CN101249268 " disinfection sterilizing type medical supersonic couplant and preparation method thereof " disclosed method, use hydroxyethyl-cellulose, carbomer (a kind of crosslinked polypropylene acid resin), wherein a kind of viscosity modifier of doing of hydroxypropyl cellulose, antibacterial is made in the combination that is selected from any one or they in poly hexamethylene biguanide, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, Trichlorophenoxy diphenyl ether, the nanometer silver.The thickening agent that they adopt all is the crosslinked polypropylene acid resin that biology is difficult to degrade; Disinfectant mostly is the organic synthesis thing, except price is higher, also can cause environmental pollution.
Summary of the invention
The purpose of this invention is to provide a kind of medical environment-friendly sterilization ultrasound coupling agent, when it is used for ultrasound examination, make detected image clear, the cross infection risk that may bring during ultrasound detection is little, ultrasonic probe there are not swelling and corrosion, and described couplant can be degraded, and is free from environmental pollution, and good environmental protection characteristic is arranged.
Technical scheme of the present invention is:
The weight portion of each composition is in the medical environment-friendly sterilization ultrasound coupling agent:
5～30 parts of corn starchs,
2～2.5 parts of 30% hydrogen peroxide,
0.04～0.08 part in ferrous sulfate,
2～2.5 parts of sodium hydroxide,
1.2～1.5 parts of Boraxs,
0.10～2.00 part of iodine,
3.00～20.00 parts of fatty alcohol-polyoxyethylene ether,
0～1.00 part of potassium iodide,
0～1.00 part of potassium iodate,
1.00 parts of ethylene glycol or glycerol,
0.20 part of citric acid,
60～78 parts in water.
The optimized technical scheme of each composition weight portion is in the medical environment-friendly sterilization ultrasound coupling agent:
10～15 parts of corn starchs,
2～2.5 parts of 30% hydrogen peroxide,
0.04～0.08 part in ferrous sulfate,
2～2.5 parts of sodium hydroxide,
1.2～1.5 parts of Boraxs,
0.25～1.00 part of iodine,
5.00～15.00 parts of fatty alcohol-polyoxyethylene ether,
0.10～0.50 part of potassium iodide,
0.10～0.50 part of potassium iodate,
1.00 parts of ethylene glycol or glycerol,
0.20 part of citric acid,
60～78 parts in water.
The particle diameter of described Semen Maydis powder is 98 orders, and described water is distilled water or deionized water.
Another object of the present invention has provided a kind of preparation method of medical environment-friendly sterilization ultrasound coupling agent, and described method raw material sources are wide, cheap, and preparation section is simple, and equipment investment is few.
The preparation method of medical environment-friendly sterilization ultrasound coupling agent has following steps:
Take off each material of row according to the proportioning of above-mentioned medical environment-friendly sterilization ultrasound coupling agent prescription
1) potassium iodide, potassium iodate after being dissolved in water, add iodine again, stir miscible after, adding citric acid, ethylene glycol, AEO-9 mix, and add the entry mixing, grind 10-20min in colloid mill, adding water to total weight parts is 50 parts, stirs, liquid is sterilized;
2) add 30% hydrogen peroxide at water, after stirring, add 98 order corn starchs, stir, add the solution that ferrous sulfate and water are made into again, stir, leave standstill 20min, make its abundant oxidation, add step 1) gained disinfectant solution, after stirring, slowly add the water-soluble solution that is made into of sodium hydroxide, reaction is to translucent, restir 10min, obtain sodium hydroxide colloid solution, Borax is dissolved in the boiled water, add in the sodium hydroxide colloid solution, stir 5min, add entry, stir, promptly get the medical ultrasonic coupling agent that environment-friendly type of the present invention has disinfecting and sterilizing functions.
The present invention has following advantage compared with prior art:
1. adopt corn starch as thickening agent, its raw material is easy to get, and price is lower, is easy to biodegradation, and is free from environmental pollution, and the feature of environmental protection is strong;
2. make disinfectant with iodine and iodine compound, can kill multiple pathogenic microbes such as various bacteria, fungus, virus, in whole testing process, all can significantly reduce the risk of the cross infection that may bring in the medical supersonic testing process to the ultrasonic probe sterilization that carries out disinfection;
3. ultrasonic coupling agent of the present invention does not have swelling and corrosion to ultrasonic probe, and its acoustical behavior and human skin tissue are approaching, and ultrasound wave power loss in transmission course is little, and detected image is clear.
4. the preparation technology of ultrasonic coupling agent of the present invention is simple, and equipment is bought easily.
Chemical compound of the present invention is the commercially available prod, wherein
AEO-9 (fatty alcohol-polyoxyethylene ether), corn starch, ferrous sulfate, sodium hydroxide, Borax, iodine, potassium iodide, potassium iodate, glycerol, ethylene glycol, citric acid all adopt the technical pure level.
Corn starch adopts food stage.
Weight portion of the present invention can go to represent with measurement units such as gram, kilogram, tons.
The invention will be further described below in conjunction with specific embodiment.
The specific embodiment
Embodiment 1
Potassium iodide 0.30kg, potassium iodate 0.15kg, add the 10kg water dissolution after, add 0.45kg iodine, stir miscible after, adding citric acid 0.20kg, ethylene glycol 2.00kg, 8kg AEO-9 mix again, add 20kg water mixing, grind 10-20min in colloid mill, adding water to gross weight again is 50kg.Stir, liquid is sterilized.
20kg water adds 2kg 30% hydrogen peroxide, after stirring, adds 98 order corn starch 10kg, stirs, and adds the solution that 0.04kg ferrous sulfate and 1.5kg water are made into again, stirs, and leaves standstill 20min, makes its abundant oxidation.Add above-mentioned disinfectant solution, after stirring, slowly add the 2kg sodium hydroxide and be dissolved in the solution that 6.5kg water is made into, reaction is to translucent, and restir 10min obtains sodium hydroxide colloid solution.The 1.2kg Borax is dissolved in the 2.5kg boiled water, adds above-mentioned sodium hydroxide colloid solution, stir 5min, add 6.5kg water, stir, through after the assay was approved, fill, packing promptly get medical environment-friendly sterilization ultrasound coupling agent of the present invention.
Embodiment 2
Potassium iodide 0.40kg, potassium iodate 0.20kg, after adding the 10kg water dissolution, add 0.30kg iodine, stir miscible after, adding citric acid 0.20kg, glycerol 2.00kg, 8kg AEO-9 mix again, add 20kg water mixing, in colloid mill, grind 10-20min, adding water to gross weight again is 50kg, stirs, and liquid is sterilized.
20kg water adds 2kg 30% hydrogen peroxide, after stirring, adds 98 order corn starch 12kg, stirs, and adds the solution that 0.04kg ferrous sulfate and 1.5kg water are made into again, stirs, and leaves standstill 20min, makes its abundant oxidation.Add above-mentioned disinfectant solution, after stirring, slowly add the 2kg sodium hydroxide and be dissolved in the solution that 6.5kg water is made into, reaction is to translucent, and restir 10min obtains sodium hydroxide colloid solution.The 1.2kg Borax is dissolved in the 2.5kg boiled water, adds above-mentioned sodium hydroxide colloid solution, stir 5min, add 6.5kg water, stir, through after the assay was approved, fill, packing promptly get medical environment-friendly sterilization ultrasound coupling agent of the present invention.
Embodiment 3
Potassium iodide 0.50kg, potassium iodate 0.30kg, after adding the 10kg water dissolution, add 0.20kg iodine, stir miscible after, adding citric acid 0.20kg, ethylene glycol 2.00kg, 8kg AEO-9 mix again, add 20kg water mixing, in colloid mill, grind 10-20min, adding water to gross weight again is 50kg, stirs, and liquid is sterilized.
20kg water adds 2kg 30% hydrogen peroxide, after stirring, adds 98 order corn starch 15kg, stirs, and adds the solution that 0.04kg ferrous sulfate and 1.5kg water are made into again, stirs, and leaves standstill 20min, makes its abundant oxidation.Add above-mentioned disinfectant solution, after stirring, slowly add the 2kg sodium hydroxide and be dissolved in the solution that 6.5kg water is made into, reaction is to translucent, and restir 10min obtains sodium hydroxide colloid solution.The 1.2kg Borax is dissolved in the 2.5kg boiled water, adds above-mentioned sodium hydroxide colloid solution, stir 5min, add 6.5kg water, stir, through after the assay was approved, fill, packing promptly get medical environment-friendly sterilization ultrasound coupling agent of the present invention.
Get the foregoing description gained couplant and carry out ultrasonic impedance, acoustic attenuation, sterilizing power, stability etc. and test, its experimental result is as follows:
Ultrasonic impedance: under 25 ℃ of conditions, viscosity 〉=15Pa.s; PH value 5.5～8; 35 ℃ record the velocity of sound is that 1510～1620m/s, specific acoustic impedance are 1.5 * 10
6～1.7 * 10
5Pa.s/m.
Acoustic attenuation: under 25 ℃ of conditions, viscosity 〉=15Pa.s; PH value 5.5～8; 35 ℃ record acoustic attenuation≤0.05db/ (cm.MHz).
1. sterilization experiment:
1.1 the preparation of bacteria suspension
Depletion Staphylococcus aureus ATCC6538 the 5th～7 generation culture, escherichia coli 8099 the 6th～8 generation culture, Pseudomonas aeruginosa ATCC15442 the 5th～7 generation culture, Candida albicans ATCC10231 the 5th～6 generation culture are test strain.Various freeze-drying lactobacillus are separated activation, get single bacterium colony, be inoculated in the 1ml fluid medium, shaking bacterium to the various bacterial concentrations of logarithmic growth after date, to be diluted to CFU be 5.0 * 106/ml.
1.2 suspension quantitative disinfecting test
Dispose each bacteria suspension during test on request, novel ultrasonic coupling agent stock solution is added each bacteria suspension, be respectively 1min, 2min and 3min the action time of couplant and bacteria suspension.Carry out count plate, calculate and kill logarithm value.19～21 ℃ of bactericidal assay temperature, test repeats 3 times.
1.3 suspension quantitative disinfecting test result
Described ultrasonic coupling agent stock solution is to staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa effect 1min, 2min, 3min, and it on average kills logarithm value all＞5.0, to oidiomycetic logarithm value＞4.0 of on average killing of white.Sterilizing rate 〉=90% to gold-coloured staphylococci, escherichia coli and Candida albicans.
Conclusion: ultrasonic coupling agent bactericidal effect of the present invention is good.
2. skin degerming field trial
Nertralizer is selected test: get ultrasonic coupling agent stock solution of the present invention, be 1min the action time of described couplant and bacteria suspension, and test temperature is 19～21 ℃, and test repeats 3 times.With " disinfection technology standard " regulation item is criterion.
Result of the test confirms, the 0.03mol/LPBS that contains 0.3% sodium thiosulfate, 1% Tween 80, can effectively neutralize ultrasonic coupling agent of the present invention to the effect of disinfectant residual in test organisms surface and the solution to test organisms, and nertralizer and neutralized reaction product have no adverse effects to test organisms and culture medium.
Select 30 volunteers, test in the inboard stage casing of forearm.One side is carried out the matched group sampling.With ultrasonic coupling agent stock solution of the present invention both arms are embrocated sterilization (about about at every turn 4mL) then, act on 2min, wipe away with aseptic cotton and smear sampling after the adhesional wetting nertralizer carries out disinfection.Test ambient temperature is 16～17 ℃, and relative humidity is 32%～35%.
The result shows: ultrasonic coupling agent stock solution of the present invention is 2.86,＞1.0 to the logarithm value of on average killing of arm part skin surface natural bacteria.
Conclusion: ultrasonic coupling agent Disinfection Effect of the present invention is good.
3. stability test
The mensuration of available iodine content is calculated its rate of descent before and after respectively three batches ultrasonic coupling agent stock solution of the present invention being deposited.Storage temperature is 37 ℃, and the resting period is 90d, 30 ℃ of testing environment temperature, relative humidity 40%～44%.
Before the result preserves in each batch ultrasonic coupling agent of the present invention the available iodine content meansigma methods be 5.38g/L; Preserve 90d in 37 ℃ of calorstats after, the available iodine content meansigma methods is 5.11g/L in each batch ultrasonic coupling agent of the present invention.Its average rate of decrease is 5.0%.
Conclusion: ultrasonic coupling agent stability of the present invention better.
Certainly; the present invention also can have other embodiment; under the situation of spirit that does not deviate from the present invention and essence, the person of ordinary skill in the field works as can make various corresponding changes according to the present invention, but these corresponding changes all should belong to the protection domain of claim of the present invention.
Claims (5)
1. medical environment-friendly sterilization ultrasound coupling agent is characterized in that the weight portion of each composition in the described couplant is:
5～30 parts of corn starchs;
2～2.5 parts of 30% hydrogen peroxide;
0.04～0.08 part in ferrous sulfate;
2～2.5 parts of sodium hydroxide;
1.2～1.5 parts of Boraxs;
0.10～2.00 part of iodine;
3.00～20.00 parts of fatty alcohol-polyoxyethylene ether;
0～1.00 part of potassium iodide;
0～1.00 part of potassium iodate;
1.00 parts of ethylene glycol or glycerol,
0.20 part of citric acid;
60～78 parts in water.
2. medical environment-friendly sterilization ultrasound coupling agent according to claim 1 is characterized in that the weight portion of each composition in the described couplant is:
10～15 parts of corn starchs;
2～2.5 parts of 30% hydrogen peroxide;
0.04～0.08 part in ferrous sulfate;
2～2.5 parts of sodium hydroxide;
1.2～1.5 parts of Boraxs;
0.25～1.00 part of iodine;
5.00～15.00 parts of fatty alcohol-polyoxyethylene ether;
0.10～0.50 part of potassium iodide;
0.10～0.50 part of potassium iodate;
1.00 parts of ethylene glycol or glycerol,
0.20 part of citric acid;
60～78 parts in water.
3. medical environment-friendly sterilization ultrasound coupling agent according to claim 1 and 2 is characterized in that: the particle diameter of described corn starch is 98 orders.
4. medical environment-friendly sterilization ultrasound coupling agent according to claim 1 and 2 is characterized in that: described water is distilled water or deionized water.
5. the preparation method of claim 1 or 2 described ultrasonic coupling agents is characterized in that following steps are arranged:
1) want 1 or 2 described proportionings to get each material of couplant according to right;
2) potassium iodide, potassium iodate after being dissolved in water, add iodine again, stir miscible after, adding citric acid, ethylene glycol, fatty alcohol-polyoxyethylene ether mix, and add the entry mixing, grind 10-20min in colloid mill, adding water to total weight parts is 50 parts, stirs, and liquid is sterilized;
3) add 30% hydrogen peroxide in the water, after stirring, add 98 order corn starchs, stir, add the solution that ferrous sulfate and water are made into again, stir, leave standstill 20min, make its abundant oxidation, add step 2) the gained disinfectant solution, after stirring, slowly add the water-soluble solution that is made into of sodium hydroxide, reaction is to translucent, restir 10min, obtain sodium hydroxide colloid solution, Borax is dissolved in the boiled water, add in the sodium hydroxide colloid solution, stir 5min, add entry, stir, promptly get the medical ultrasonic coupling agent that described environment-friendly type has disinfecting and sterilizing functions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009103081423A CN101658680B (en) | 2009-10-09 | 2009-10-09 | Medical environment-friendly sterilization ultrasound coupling agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009103081423A CN101658680B (en) | 2009-10-09 | 2009-10-09 | Medical environment-friendly sterilization ultrasound coupling agent and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101658680A CN101658680A (en) | 2010-03-03 |
| CN101658680B true CN101658680B (en) | 2011-02-09 |
Family
ID=41787075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009103081423A Expired - Fee Related CN101658680B (en) | 2009-10-09 | 2009-10-09 | Medical environment-friendly sterilization ultrasound coupling agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101658680B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101889580B (en) * | 2010-07-22 | 2011-12-14 | 海南橡宝生物科技有限公司 | Composition for controlling tapping panel dryness |
| CN102500599B (en) * | 2011-10-28 | 2014-01-15 | 合肥市东方美捷分子材料技术有限公司 | Deodorizing environment induction material |
| CN103875741B (en) * | 2014-03-18 | 2016-04-27 | 苏晓婷 | A kind of probe thimerosal and preparation method thereof |
| CN103893784B (en) * | 2014-03-18 | 2016-03-02 | 苏晓婷 | A kind of sterilization ultrasonic coupling agent and preparation method thereof |
| CN103977432B (en) * | 2014-03-24 | 2016-08-17 | 济南伟传信息技术有限公司 | A kind of Color Sonography ultrasonic coupling agent |
| CN106342886A (en) * | 2016-08-30 | 2017-01-25 | 四川创美克科技有限公司 | Compound type active iodine disinfectant for livestock, preparing method and purpose thereof |
| CN106937646B (en) * | 2017-03-29 | 2021-01-01 | 佛山市南海东方澳龙制药有限公司 | Preparation method of iodic acid mixed solution and iodic acid mixed solution prepared by same |
| CN107389801A (en) * | 2017-06-09 | 2017-11-24 | 艾因蒂克检测科技（上海）股份有限公司 | A kind of couplant for resistance spot welding ultrasound examination and preparation method thereof |
| CN107670057A (en) * | 2017-10-17 | 2018-02-09 | 聂志惠 | A kind of efficient medical ultrasonic coupling agent and preparation method thereof |
| CN110755644B (en) * | 2018-07-25 | 2023-06-16 | 苏州安德佳生物科技有限公司 | Biocompatible ultrasonic coupling agent for endoscope and application thereof |
| CN111567554B (en) * | 2020-06-17 | 2021-05-18 | 成都市图腾环保科技有限公司 | Synthetic runway surface disinfectant, preparation method thereof and synthetic runway surface disinfection method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3621709A (en) * | 1969-01-28 | 1971-11-23 | Automation Ind Inc | Ultrasonic couplant |
| CN1087016A (en) * | 1992-11-14 | 1994-05-25 | 鞍山钢铁公司 | The preparation method of medical ultrasonic coupling agent |
| US5522878A (en) * | 1988-03-25 | 1996-06-04 | Lectec Corporation | Solid multipurpose ultrasonic biomedical couplant gel in sheet form and method |
| CN1374133A (en) * | 2002-03-21 | 2002-10-16 | 黎国梓 | B-mode ultrasound coupling agent and its prepn |
| CN1820725A (en) * | 2006-01-02 | 2006-08-23 | 赵建中 | Supersonic anti-cross infection device in operation |
-
2009
- 2009-10-09 CN CN2009103081423A patent/CN101658680B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3621709A (en) * | 1969-01-28 | 1971-11-23 | Automation Ind Inc | Ultrasonic couplant |
| US5522878A (en) * | 1988-03-25 | 1996-06-04 | Lectec Corporation | Solid multipurpose ultrasonic biomedical couplant gel in sheet form and method |
| CN1087016A (en) * | 1992-11-14 | 1994-05-25 | 鞍山钢铁公司 | The preparation method of medical ultrasonic coupling agent |
| CN1374133A (en) * | 2002-03-21 | 2002-10-16 | 黎国梓 | B-mode ultrasound coupling agent and its prepn |
| CN1820725A (en) * | 2006-01-02 | 2006-08-23 | 赵建中 | Supersonic anti-cross infection device in operation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101658680A (en) | 2010-03-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101658680B (en) | Medical environment-friendly sterilization ultrasound coupling agent and preparation method thereof | |
| CA2794552C (en) | Deformable mass for disinfecting surfaces, based on cross-linked hydropropylated polygalactomannan | |
| TW200395B (en) | ||
| CN101642449B (en) | Skin mucous membrane disinfectants and preparation method thereof | |
| CN103271836A (en) | Non-cytotoxic chlorine dioxide fluids | |
| JP6129843B2 (en) | Disinfecting compositions and their use | |
| CN101219223A (en) | Medical supersonic couplant with disinfection function and method for preparing the same | |
| CN105658055A (en) | Antimicrobial compositions | |
| CN104039154A (en) | Non-corrosive stable peracetic acid concentrate solution | |
| CN111450116A (en) | Preparation and application of antibacterial nano enzyme disinfection gel | |
| CN102107013B (en) | Sterile ultrasound coupling agent for invasive ultrasound diagnosis and treatment and preparation method thereof | |
| CN101810198B (en) | Salicylic acid-iodine disinfector and preparation method thereof | |
| CN101718465A (en) | Self-heating medical ultrasonic coupling agent device with sterilization and disinfection effects and preparation thereof | |
| CN101987201B (en) | Medical ultrasonic probe sterilizing gel and preparation method thereof | |
| Sun et al. | Towards greener and more sustainable cellulose-based hand sanitizer products | |
| CN101032244B (en) | Disinfectant formulation and producing method thereof | |
| CN102085382B (en) | Special sterilizing medical ultrasound couplant for ophthalmology and preparation method thereof | |
| US20240224996A1 (en) | Liquid chemical sterilization chemistry | |
| CN101711882A (en) | Medical ultrasound coupling agent with function of fast and efficient sterilization and device thereof | |
| CN101797391B (en) | Disposable bactericidal medical ultrasonic couplant and preparation method thereof | |
| CN102133409B (en) | Sterilizing type medical ultrasonic coupling agent and preparation method thereof | |
| CN1063598A (en) | The production method of quick-effective iodine disinfectant | |
| CN112220695A (en) | Disinfection washing-free hand cleaning gel and preparation method thereof | |
| TW200820998A (en) | Bactericidal composition | |
| CN107306992A (en) | A kind of salicylic acid-iodine powder disinfectant and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110209 Termination date: 20141009 |
|
| EXPY | Termination of patent right or utility model |