CN101628068A - Pharmaceutical composition for treating juvenile poliosis and preparation method thereof - Google Patents
Pharmaceutical composition for treating juvenile poliosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for treating juvenile poliosis and a preparation method thereof. The pharmaceutical composition comprises the following components: prepared rehmannia root, prepared radix polygoni multiflori, Chinese dodder, Chinese yam, Chinese angelica root, dried rehmannia root, wolfberry fruit, Tuckahoe, oriental water plantain rhizome, moutan bark, eclipta alba, liquorice, glossy privet fruit, astragalus root, black soya bean and black sesame seed. The preparation method comprises the following steps: crushing the Chinese yam, the tuckahoe and the black sesame seed into fine powder; distilling the Chinese angelica root and the moutan bark in water to collect distillate, and adding beta-CD for inclusion to obtain a beta-CD inclusion compound; decocting the rest medicinal herbs such as the prepared rehmannia root, the Chinese dodder, the dried rehmannia root, the oriental water plantain rhizome, the astragalus root, and the like by adding water, then filtering the decoction, and concentrating the filtrate into a proper amount; and adding conventional preparation auxiliary materials into the medicines to mix and prepare various conventional oral preparations such as capsules, tablets, granules, pills, and the like. The pharmaceutical composition is a pure Chinese herbal preparation and also has the advantages of low price and easily obtained raw materials, no toxic side effect, simple, convenient and feasible preparation process, fast effect and high curative ratio.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of drug regimen for the treatment of poliosis and preparation method thereof, especially a kind of drug regimen for the treatment of juvenile poliosis and preparation method thereof.
Background technology
At present, owing to inherited genetic factors, diet conservancy is improper and the multiple reason of study and work emotion pressure to cause teenager the crowd of poliosis to occur more and more, medically claim juvenile poliosis, be commonly called as " teen-ager leukotrichia ", increased many worries for the at life's full flowering teenager personage that particularly likes to be beautiful.The occurrence cause more complicated of teen-ager leukotrichia, both relevant, relevant with posteriori various factors again with heritability, body constitution sexual factor.The posteriority teen-ager leukotrichia.The reason that causes is a lot: malnutrition as lacking protein, vitamin and some trace element (as copper) etc., all can make hair bleach; Some Chronic consumptions such as tuberculosis etc., because of causing malnutrition, hair also gets earlier than the white of common people; Patients of some long-term heatings, hair is can be yellow crisp even bleach and come off; The endocrinopathy that has as hypophysis cerebri or thyroid illness, can influence the particulate ability of pigment cell's chromogenesis and causes hair to bleach too early; Encephalitis, nervous system lesion etc. also can make hair bleach; The somebody thinks that it is many more to require mental skill, and hair Bai Deyue early; Some adolescent at short notice, hair bleaches in a large number, and is then overtired relevant with serious psychic trauma such as overanxiexty, sadness or spirit.The medicine for the treatment of poliosis on the market is a lot, but all is the medicine of single kidney tonifying and enriching blood mostly, and Time of Administration is long, and curative effect also may not be certain; Even some people is in order to reach the effect of black hair as early as possible, do not stint the hormone medicine of utilization high price, although have can reach black hair effect faster, but consequent side effect causes no small injury to health, the result also loses more than gain, and the curative effect instability, easily recurrence.As seen the patient need treating both the principal and secondary aspects of a disease, determined curative effect, instant effect in a hurry, the pure Chinese medicinal preparation of the treatment poliosis that has no side effect.
Summary of the invention
Purpose of the present invention just be to poliosis patient especially juvenile poliosis patient provide that a kind of cure rate height, safe without toxic side effect, inexpensive effect are good, the drug regimen of short treating period instant effect, treating both the principal and secondary aspects of a disease.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of drug regimen for the treatment of juvenile poliosis, the weight proportion of each component is as follows: 8～12 parts in Radix Rehmanniae Preparata, 10～15 parts of Radix Polygoni Multiflori Preparatas, 8～12 parts of Semen Cuscutae, 3～9 parts of Fructus Lycii, 9～12 parts of the Radixs Astragali, 8～12 parts of Radix Angelicae Sinensis, 8～12 parts of Rhizoma Dioscoreaes, 6～10 parts of Fructus Ligustri Lucidi, 6～10 parts in the Radix Rehmanniae, 4～9 parts in Poria, 3～6 parts of Rhizoma Alismatis, 4～8 parts of Cortex Moutans, 9～16 parts in Semen sojae atricolor, 12～18 parts of Semen Sesami Nigrums, 3～9 parts of Herba Ecliptaes, 3～9 parts in Radix Glycyrrhizae.
Therefrom the weight proportion of preferred each component is: 12 parts in Radix Rehmanniae Preparata, 12 parts of Radix Polygoni Multiflori Preparatas, 8 parts of Semen Cuscutae, 4 parts of Fructus Lycii, 12 parts of the Radixs Astragali, 8 parts of Radix Angelicae Sinensis, 8 parts of Rhizoma Dioscoreaes, 8 parts of Fructus Ligustri Lucidi, 6 parts in the Radix Rehmanniae, 4 parts in Poria, 4 parts of Rhizoma Alismatis, 4 parts of Cortex Moutans, 12 parts in Semen sojae atricolor, 12 parts of Semen Sesami Nigrums, 4 parts of Herba Ecliptaes, 4 parts in Radix Glycyrrhizae.
Huang di's Canon of Medicine has cloud: " hair is the sign of blood condition, tooth being the surplus of the bone ", deficiency of both the liver and kidney, last flourish in the asthenia of essence and blood of beard and hair, so early whitening of beard and hair.Reuse Radix Rehmanniae Preparata, Radix Polygoni Multiflori among the we, nourishing the liver and kidney, life essence-filling, marrow-benefitting, foster essence is enriched blood, and is monarch drug altogether.Fructus Lycii, Semen Cuscutae are gone into Liver and kidney, the kidney invigorating and essence nourishing, and nourishing the liver is enriched blood; Radix Astragali compatibility Radix Angelicae Sinensis, QI invigorating and blood producing is enriched blood; Rhizoma Dioscoreae compatibility Fructus Corni is taken a tonic or nourishing food to build up one's health liver spleen kidney, and the energy arresting seminal emission; Fructus Ligustri Lucidi compatibility Herba Ecliptae, the tonifying liver kidney yin, crow must make eye bright; Semen sojae atricolor compatibility Semen Sesami Nigrum, the kidney tonifying that nourishes blood, the tonify deficiency black hair is ministerial drug altogether.Radix Rehmanniae YIN nourishing removing heat from blood; The Rhizoma Alismatis dampness removing is let out turbid; Cortex Moutan is let out fire mutually clearly; Poria spleen reinforcing kidney, eliminating dampness by diuresis is turbid, is adjuvant drug altogether.Take a broad view of full side, invigorating middle warmer has rushes down, grow and oiliness, and replenishing the kidney(water)to nourish the liver(wood), YIN nourishing benefit intensive culture blood is main, takes into account tonifying Qi and lifting yang, and tonifying both YIN and YANG is arranged, essence and blood alternate wonderful.
In sum, we have that nourishing the liver and kidney, beneficial essence are enriched blood, the effect of blood-activating and qi-promoting, are applicable to the juvenile poliosis that brain overwork, QI and blood deficiency, the hepatic and renal YIN deficiency cause.
The present invention is prepared from by following method step:
1. weighing is standby after getting Rhizoma Dioscoreae, Poria, the Semen Sesami Nigrum removal of impurity, is ground into fine powder with Universalpulverizer, crosses 100 mesh sieves, abundant mixing, mixing fine powders A;
2. Radix Angelicae Sinensis, Cortex Moutan vapor distillation are collected volatile oil, add β-CDBao He, get beta-CD inclusion B;
3. flavour of a drug extracting in water secondaries such as Radix Polygoni Multiflori Preparata, Radix Rehmanniae Preparata, Semen Cuscutae, the Radix Rehmanniae, Fructus Lycii, Herba Ecliptae, Fructus Ligustri Lucidi, Semen sojae atricolor, each each 2 hours, collecting decoction, and mix with Radix Angelicae Sinensis, Paeonia suffruticosa severe edema due to hypofunction of the spleen extract, filter, filtrate is concentrated in right amount, must mix thick paste C;
4. with A, B and C mix homogeneously, add the conventional formulation adjuvant, mixing, make conventional solid orally ingestible.
β-CDBao He in the step 2 is β-CD and volatile oil with 1: 6～1: 10 ratio enclose, leaves standstill sucking filtration, and cold drying is pulverized, and promptly gets clathrate; Decocting with water to adding 10 times of amounts of water for the first time in the step 3 decocted 2 hours, added 8 times of amounts of water for the second time, decocted 2 hours; Being concentrated in the step 3 is an amount of for being concentrated into the thick paste that relative density is 1.20～1.25 (60 ℃ of surveys).
Conventional solid orally ingestible is capsule, tablet, granule or pill.
Drug regimen compatibility of the present invention is precise and appropriate, and raw material is cheap and easy to get, all is the Chinese herbal medicine of pure natural, safe without toxic side effect, preparation technology is simple and feasible, and the treatment juvenile poliosis is had good curative effect, and instant effect, 30 days courses of treatment, take effect a general course of treatment, and can fully recover 3～5 courses of treatment.
The source of each component, performance and effect in the raw material of the present invention:
Radix Rehmanniae Preparata: sweet in the mouth tepor matter profit, return liver, kidney channel.The YIN nourishing of both having enriched blood again can vital essence replenishing and marrow benifiting.Be used for the Liver and kidney essence and blood and lose empty soreness of the waist and knees, vertigo and tinnitus, early whitening of beard and hair etc.
Radix Polygoni Multiflori Preparata: Compendium of Material Medica record, " this thing temperature, bitter and puckery flavor.Bitter the kidney invigorating, the temperature compensation liver wetly can be restrained vital essence.The liver benefiting so can nourish blood, the controlling nocturnal emission with astringent drugs kidney tonifying, muscle reinforcing and bone strengthening, black moustache is sent out, and is tonic medicine, and is cold not dry, and merit is on Radix Rehmanniae, day doorway winter thread medicine." but the treating the liver kidney yin loses, sending out must be early white.
Semen Cuscutae: warm in nature, sweet in the mouth.Nourishing the liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal.The waist knee joint muscles and bones that is applicable to deficiency of the liver and kindey is ached, diseases such as legs and feet weakness, impotence and seminal emission, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Rhizoma Dioscoreae: the flat sweet in the mouth of property.The spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Be used for that insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung are breathed with cough, card such as emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat are quenched one's thirst.
Radix Angelicae Sinensis: the hot warm sweet in the mouth of property.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Rehmanniae: cold in nature, sweet in the mouth, hardship.GUIXIN, liver, lung meridian.Function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in treating diseases such as hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.
Fructus Lycii: the flat sweet in the mouth of property, the profit and nourish.Return liver, kidney channel.Function is a nourishing the liver and kidney, replenishing vital essence to improve eyesight.Key medicine for Liver and kidney kidney-YIN being deficient, tired interior-heat tonification.Be used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.
Poria: the flat slightly sweet flavor of property, diuretic is wet with the swollen dysuria of harnessing the river, and the drink that reduces phlegm is gone into the disease of network to control cough, phlegm-damp, strengthening the spleen and stomach and can the antidiarrheal leukorrhagia stopping, mind calming god controls palpitation with fear and has a sleepless night.The property of medicine is gentle, does not have the fraud of hindering healthy energy, can set upright with it, again can be eliminating evil, so insufficiency of the spleen leading to overabundance of dampness, the disease of vital QI being weakened and pathogen being violent is particularly suitable.
Rhizoma Alismatis: property is flat, and sweet in the mouth is and light, and light can oozing let out, and abnormal smells from the patient is all thin, so diuretic and diarrhea.Taste have damp and hot, then nose heave and blurred vision tinnitus, and Rhizoma Alismatis oozes that it is wet, and then heat is also with going, and rustic must the order, and clearing heat in QI system is up, and weather is bright refreshing, so Rhizoma Alismatis has foster the five internal organs, physical strength profiting, controls and revolve the merit of clever knowledge.
Cortex Moutan: cold in nature, bitter in the mouth, suffering.Clearing away heat and cooling blood, blood circulation promoting competent silt.Compendium of Material Medica cloud: control the blood fire second of the three ten-day periods of the hot season, heat clearing away and restlessness relieving.Be used for maculae caused by violent heat pathogen, tell, be defeated in battle, have blood in stool, the hectic fever due to YIN-deficiency consumptive fever, the amenorrhea dysmenorrhea, carbuncle sore tumefacting virus falls and pounces on the pain of injury.
Herba Ecliptae: sweet in the mouth acid cool in nature, go into liver, kidney channel.But the merit removing heat from blood, hemostasis, the kidney invigorating, tonifying YIN.Herba Ecliptae frequency of utilization in the Chinese medicine beautifying ancient prescription is high, thinks crow palpus hair color, the key medicine of growth hair.Control early whitening of beard and hair, spit blood, hematuria is had blood in stool, dysentery, and knife injury is hemorrhage, diphtheria, stranguria with turbid discharge, leukorrhagia, pudendum pruritus due to damp pathogen, mouse nevus etc.
Radix Glycyrrhizae: property is flat, and sweet in the mouth is returned 12 warps.But the merit invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Fructus Ligustri Lucidi: sweet in the mouth, little bitterness.The tonifying liver kidney yin, crow must make eye bright.The poor vision that is used for the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.
The Radix Astragali: the property of medicine is sweet, tepor.Return spleen, lung meridian.Function is the spleen invigorating invigorating middle warmer, ascending up spleen-Qi and Yang, and benefit is defended consolidating superficial resistance, diuresis, promoting pus discharge and tissue regeneration strengthening.Be the key medicine of invigorating the spleen and replenishing QI, the compatibility Radix Angelicae Sinensis, the effect of enriching blood is remarkable.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis etc.
Semen sojae atricolor: nature and flavor are sweet, flat, nontoxic.Have invigorate blood circulation, diuretic, dispel the wind, the function of the strong blood of heat-clearing and toxic substances removing, nourishing, tonify deficiency black hair.It is thanks to cloudy to be used to suffer from a deficiency of the kidney, the polydipsia of quenching one's thirst, frequent micturition; The hepatic and renal YIN deficiency is had a dizzy spell, poor vision, or early whitening of beard and hair; Beriberi edema, or arthralgia chiefly caused by damp pathogen contracture, lumbago etc.
Semen Sesami Nigrum: sweet, flat.Return liver, kidney, large intestine channel.Contain a large amount of fat and protein, and nutritional labeling such as saccharide, vitamin A, vitamin E, lecithin, calcium, ferrum, chromium, the effect of have invigorating the liver and kidney, moistening five ZANG-organs, physical strength profiting, longue meat, filling out brains, be used for the treatment of dizzy, early whitening of beard and hair, alopecia, soreness of the waist and knees, limbs fatigue due to the Liver and kidney asthenia of essence and blood, walk with difficulty, disease such as deficient five internal organs, the dry dried and withered hairs of skin, dryness of the intestine constipation, effect aspect blacking hair and nourishing face, celebrated especially.
The specific embodiment
Embodiment 1: capsule
1. weighing is standby after getting the crude drug removal of impurity respectively according to prescription composition and weight proportion.Radix Rehmanniae Preparata 120 grams, Radix Polygoni Multiflori Preparata 120 grams, Semen Cuscutae 80 grams, Fructus Lycii 40 grams, the Radix Astragali 120 grams, Radix Angelicae Sinensis 80 grams, Rhizoma Dioscoreae 80 grams, Fructus Ligustri Lucidi 80 grams, the Radix Rehmanniae 60 grams, Poria 40 grams, Rhizoma Alismatis 40 grams, Cortex Moutan 40 grams, Semen sojae atricolor 120 grams, Semen Sesami Nigrum 120 grams, Herba Ecliptae 40 grams, Radix Glycyrrhizae 40 grams.
2. get Rhizoma Dioscoreae, Poria, Semen Sesami Nigrum, be ground into fine powder with Universalpulverizer respectively, cross 100 mesh sieves, fully mixing gets mixing fine powders A.
3. Radix Angelicae Sinensis, Cortex Moutan add 12 times of water gaging distillations, collect volatile oil, adopt β-CD and volatile oil with 1: 8 ratio colloid mill enclose, the enclose temperature is 30 ℃, and the enclose time is 30 minutes, leaves standstill behind the enclose 24 hours, sucking filtration gets clathrate, in 45 ℃ of cold drying, pulverize 80 mesh sieves then, got beta-CD inclusion B.
4. nine flavors such as Radix Polygoni Multiflori Preparata, Radix Rehmanniae Preparata, Semen Cuscutae, the Radix Rehmanniae, Fructus Lycii, Herba Ecliptae, Fructus Ligustri Lucidi, Semen sojae atricolor mix with distillation back medicinal residues, decoct with water secondary, add 10 times of amounts of water for the first time, add 8 times of amounts of water for the second time, respectively decocted 2 hours at every turn, collecting decoction filters, and the water extract after filtrate and the distillation merges, be evaporated to relative density and be about the thick paste of 1.20～1.25 (60 ℃ of surveys), the employing vacuum drying (vacuum-0.04～-0.07MPA, 60～80 ℃ of temperature), powder C gets dry extract.
5. with the about 220g of gained fine powder A, the about 40g of clathrate B and the about 130g mix homogeneously of dried cream powder C,, cross 14 mesh sieve system wet granulars with 40% ethanol system soft material, 60 ℃ of cold drying, granulate is adorned capsule No. 1, makes about 1000 altogether.
Usage and dosage: oral, one time 3,3 times on the one, one month is a course of treatment.
Embodiment 2: tablet
1. weighing is standby after getting the crude drug remove impurity respectively according to prescription composition and weight proportion.Radix Rehmanniae Preparata 120 grams, Radix Polygoni Multiflori Preparata 120 grams, Semen Cuscutae 80 grams, Fructus Lycii 40 grams, the Radix Astragali 120 grams, Radix Angelicae Sinensis 80 grams, Rhizoma Dioscoreae 80 grams, Fructus Ligustri Lucidi 80 grams, the Radix Rehmanniae 67 grams, Poria 40 grams, Rhizoma Alismatis 40 grams, Cortex Moutan 40 grams, Semen sojae atricolor 120 grams, Semen Sesami Nigrum 133 grams, Herba Ecliptae 40 grams, Radix Glycyrrhizae 40 grams.
2. get Rhizoma Dioscoreae, Poria, Semen Sesami Nigrum, be ground into fine powder with Universalpulverizer respectively, cross 100 mesh sieves, fully mixing gets mixing fine powders A.
3. Radix Angelicae Sinensis, Cortex Moutan add 12 times of water gaging distillations, collect volatile oil, adopt β-CD and volatile oil with 1: 6 ratio colloid mill enclose, the enclose temperature is 40 ℃, and the enclose time is 30 minutes, leaves standstill behind the enclose 24 hours, sucking filtration gets clathrate, in 70 ℃ of cold drying, pulverize 80 mesh sieves then, got beta-CD inclusion B.
4. nine flavors such as Radix Polygoni Multiflori Preparata, Radix Rehmanniae Preparata, Semen Cuscutae, the Radix Rehmanniae, Fructus Lycii, Herba Ecliptae, Fructus Ligustri Lucidi, Semen sojae atricolor mix with distillation back medicinal residues, decoct with water secondary, add 10 times of amounts of water for the first time, add 8 times of amounts of water for the second time, respectively decocted 2 hours at every turn, collecting decoction filters, and the water extract after filtrate and the distillation merges, be evaporated to relative density and be about the thick paste of 1.25～1.30 (60 ℃ of surveys), the employing vacuum drying (vacuum-0.04～-0.07MPA, 60～80 ℃ of temperature), powder C gets dry extract.
5. with fine powder A, clathrate B and dried cream powder C mix homogeneously, with 40% ethanol system soft material, cross 14 mesh sieve system wet granulars, 60～80 ℃ of cold drying add an amount of magnesium stearate, and compressed tablets is made about 1000.
Usage and dosage: oral, one time 3,3 times on the one, one month is a course of treatment.
Embodiment 3: granule
1. weighing is standby after getting the crude drug remove impurity respectively according to prescription composition and weight proportion.Radix Rehmanniae Preparata 150 grams, Radix Polygoni Multiflori Preparata 150 grams, Semen Cuscutae 100 grams, Fructus Lycii 60 grams, the Radix Astragali 150 grams, Radix Angelicae Sinensis 120 grams, Rhizoma Dioscoreae 120 grams, Fructus Ligustri Lucidi 100 grams, the Radix Rehmanniae 100 grams, Poria 60 grams, Rhizoma Alismatis 60 grams, Cortex Moutan 60 grams, Semen sojae atricolor 150 grams, Semen Sesami Nigrum 140 grams, Herba Ecliptae 80 grams, Radix Glycyrrhizae 60 grams.
2. get Rhizoma Dioscoreae, Poria, Semen Sesami Nigrum, be ground into fine powder with Universalpulverizer respectively, cross 100 mesh sieves, fully mixing gets mixing fine powders A.
3. Radix Angelicae Sinensis, Cortex Moutan add 12 times of water gaging distillations, collect volatile oil, adopt β-CD and volatile oil with 1: 10 ratio colloid mill enclose, the enclose temperature is 50 ℃, and the enclose time is 30 minutes, leaves standstill behind the enclose 24 hours, sucking filtration gets clathrate, in 60 ℃ of cold drying, pulverize 80 mesh sieves then, got beta-CD inclusion B.
4. nine flavors such as Radix Polygoni Multiflori Preparata, Radix Rehmanniae Preparata, Semen Cuscutae, the Radix Rehmanniae, Fructus Lycii, Herba Ecliptae, Fructus Ligustri Lucidi, Semen sojae atricolor mix with distillation back medicinal residues, decoct with water secondary, add for the first time 10 times of amounts of water, add for the second time 8 times of amounts of water, respectively decocted 2 hours, collecting decoction filters at every turn, water extract after filtrate and the distillation merges, and is evaporated to the thick paste C that relative density is about 1.25～1.30 (60 ℃ of surveys).
5. with fine powder A, clathrate B and thick paste C mix homogeneously, add an amount of Icing Sugar and do binding agent, add appropriate amount of starch and do diluent, the preparation soft material sieves, and drying is made about 1500g granule, is distributed into 150 bags, every bag 10 gram.
Usage and dosage: oral, one time 1 bag, 3 times on the one, one month is a course of treatment.
Embodiment 4: water pill
1. weighing is standby after getting the crude drug remove impurity respectively according to prescription composition and weight proportion.Radix Rehmanniae Preparata 90 grams, Radix Polygoni Multiflori Preparata 90 grams, Semen Cuscutae 60 grams, Fructus Lycii 30 grams, the Radix Astragali 90 grams, Radix Angelicae Sinensis 60 grams, Rhizoma Dioscoreae 60 grams, Fructus Ligustri Lucidi 60 grams, the Radix Rehmanniae 50 grams, Poria 30 grams, Rhizoma Alismatis 30 grams, Cortex Moutan 30 grams, Semen sojae atricolor 90 grams, Semen Sesami Nigrum 100 grams, Herba Ecliptae 30 grams, Radix Glycyrrhizae 30 grams.
2. get Rhizoma Dioscoreae, Poria, Semen Sesami Nigrum, be ground into fine powder with Universalpulverizer respectively, cross 100 mesh sieves, fully mixing gets mixing fine powders A.
3. Radix Angelicae Sinensis, Cortex Moutan add 12 times of water gaging distillations, collect volatile oil, adopt β-CD and volatile oil with 1: 10 ratio colloid mill enclose, the enclose temperature is 40 ℃, and the enclose time is 30 minutes, leaves standstill behind the enclose 24 hours, sucking filtration gets clathrate, in 50 ℃ of cold drying, pulverize 80 mesh sieves then, got beta-CD inclusion B.
4. nine flavors such as Radix Polygoni Multiflori Preparata, Radix Rehmanniae Preparata, Semen Cuscutae, the Radix Rehmanniae, Fructus Lycii, Herba Ecliptae, Fructus Ligustri Lucidi, Semen sojae atricolor mix with distillation back medicinal residues, decoct with water secondary, add 10 times of amounts of water for the first time, add 8 times of amounts of water for the second time, respectively decocted 2 hours at every turn, collecting decoction filters, and the water extract after filtrate and the distillation merges, be evaporated to relative density and be about the thick paste of 1.25～1.30 (60 ℃ of surveys), the employing vacuum drying (vacuum-0.04～-0.07MPA, 60～80 ℃ of temperature), powder C gets dry extract.
5. with fine powder A, clathrate B and dried cream powder C mix homogeneously, the general micropill of making of water, coating hits light, and drying is made about 1000g, every packed 1.25g.
Usage and dosage: oral, one time 2 bags, 3 times on the one, one month is a course of treatment.
Claims (5)
1, a kind of drug regimen for the treatment of juvenile poliosis is characterized in that it being to be made by following component and weight proportion:
6～10 parts of 9～15 parts of Semen Cuscutae of 9～15 parts of Radix Polygoni Multiflori Preparatas of Radix Rehmanniae Preparata
6～12 parts of 9～15 parts of Radix Angelicae Sinensis of 3～6 parts of Radixs Astragali of Fructus Lycii
5～10 parts in 6～10 parts of Radix Rehmanniae of 6～12 parts of Fructus Ligustri Lucidi of Rhizoma Dioscoreae
3～6 parts of 3～6 parts of Cortex Moutans of 3～6 portions of Rhizoma Alismatis of Poria
3～8 parts of 10～14 portions of Herba Ecliptaes of 9～15 portions of Semen Sesami Nigrums of Semen sojae atricolor
3～6 parts in Radix Glycyrrhizae.
2, a kind of drug regimen for the treatment of juvenile poliosis according to claim 1 is characterized in that the preferred weight proportioning of each component is:
4 parts of 8 parts of Fructus Lycii of 12 parts of Semen Cuscutae of 12 parts of Radix Polygoni Multiflori Preparatas of Radix Rehmanniae Preparata
8 parts of 8 parts of Fructus Ligustri Lucidi of 8 portions of Rhizoma Dioscoreaes of 12 parts of Radix Angelicae Sinensis of the Radix Astragali
4 parts of 4 parts of Cortex Moutans of 4 portions of Rhizoma Alismatis of 6 parts of Poria of the Radix Rehmanniae
4 parts in 4 portions of Radix Glycyrrhizaes of 12 portions of Herba Ecliptaes of 12 portions of Semen Sesami Nigrums of Semen sojae atricolor.
3, a kind of preparation method for the treatment of the drug regimen of juvenile poliosis is characterized in that adopting following steps:
(1) get Rhizoma Dioscoreae, Poria, the Semen Sesami Nigrum removal of impurity after weighing standby, be ground into fine powder with Universalpulverizer, cross 100 mesh sieves, abundant mixing, mixing fine powders A;
(2) Radix Angelicae Sinensis, Cortex Moutan vapor distillation are collected volatile oil, add β-CDBao He, get beta-CD inclusion B;
(3) flavour of a drug extracting in water secondaries such as Radix Polygoni Multiflori Preparata, Radix Rehmanniae Preparata, Semen Cuscutae, the Radix Rehmanniae, Fructus Lycii, Herba Ecliptae, Fructus Ligustri Lucidi, Semen sojae atricolor, each each 2 hours, collecting decoction, and mix with Radix Angelicae Sinensis, Paeonia suffruticosa severe edema due to hypofunction of the spleen extract, filter, filtrate is concentrated in right amount, must mix thick paste C;
(4) with A, B and C mix homogeneously, add the conventional formulation adjuvant, mixing, make conventional solid orally ingestible.
4, the preparation method of the drug regimen of treatment juvenile poliosis as claimed in claim 3 is characterized in that: conventional solid orally ingestible is capsule, tablet, granule or pill.
5, the preparation method of the drug regimen of treatment juvenile poliosis as claimed in claim 3, it is characterized in that: the β-CDBao He in the step (2) is β-CD and volatile oil with 1: 6～1: 10 ratio enclose, leaves standstill sucking filtration, cold drying, pulverize, promptly get clathrate; Decocting with water to adding 10 times of amounts of water for the first time in the step (3) decocted 2 hours, added 8 times of amounts of water for the second time, decocted 2 hours; In the step (3) to be concentrated into an amount of be 1.20～1.25/60 ℃ thick paste for being concentrated into relative density.
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| CN200910114310A CN101628068A (en) | 2009-08-14 | 2009-08-14 | Pharmaceutical composition for treating juvenile poliosis and preparation method thereof |
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| CN101926915A (en) * | 2010-08-20 | 2010-12-29 | 殷晓娜 | Orally taken Chinese medicinal composition for treating premature graying |
| CN102166288A (en) * | 2011-04-06 | 2011-08-31 | 高启朋 | Chinese medicinal composition for treating juvenile canities and preparation method thereof |
| CN102178215A (en) * | 2010-12-01 | 2011-09-14 | 叶建斌 | Formula and preparation method of health-care ointment for blacking hair and tonifying kidney |
| CN103505542A (en) * | 2013-10-16 | 2014-01-15 | 南阳市食用菌技术交流中心（普通合伙） | Composition capable of growing and blackening hair |
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| CN101926915A (en) * | 2010-08-20 | 2010-12-29 | 殷晓娜 | Orally taken Chinese medicinal composition for treating premature graying |
| CN102178215A (en) * | 2010-12-01 | 2011-09-14 | 叶建斌 | Formula and preparation method of health-care ointment for blacking hair and tonifying kidney |
| CN102178215B (en) * | 2010-12-01 | 2012-11-21 | 叶建斌 | Formula and preparation method of health-care ointment for blacking hair and tonifying kidney |
| CN102166288A (en) * | 2011-04-06 | 2011-08-31 | 高启朋 | Chinese medicinal composition for treating juvenile canities and preparation method thereof |
| CN102166288B (en) * | 2011-04-06 | 2012-07-25 | 高启朋 | Chinese medicinal composition for treating juvenile canities and preparation method thereof |
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| CN105878549A (en) * | 2016-04-19 | 2016-08-24 | 劳炳凤 | Preparation method of quick-acting hair-blackening pills |
| CN107126496A (en) * | 2017-05-16 | 2017-09-05 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | It is a kind of to treat traditional Chinese medicine pill of white hair and preparation method thereof |
| CN108888687A (en) * | 2018-08-24 | 2018-11-27 | 楚雄齐苏堂中医门诊部 | A kind of pharmaceutical composition of tonifying kidney and hairs and the preparation method and application thereof |
| CN112569290A (en) * | 2019-09-11 | 2021-03-30 | 张士强 | Traditional Chinese medicine for treating juvenile poliosis and preparation method thereof |
| CN110538258A (en) * | 2019-09-12 | 2019-12-06 | 郭运山 | traditional Chinese medicine formula for treating alopecia and leukotrichia and preparation method thereof |
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