CN101612221B - Pawpaw nutritional effervescence tablet and preparation method thereof - Google Patents
Pawpaw nutritional effervescence tablet and preparation method thereof Download PDFInfo
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- CN101612221B CN101612221B CN200910104509XA CN200910104509A CN101612221B CN 101612221 B CN101612221 B CN 101612221B CN 200910104509X A CN200910104509X A CN 200910104509XA CN 200910104509 A CN200910104509 A CN 200910104509A CN 101612221 B CN101612221 B CN 101612221B
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Abstract
The invention discloses a pawpaw nutritional effervescence tablet and a preparation method thereof. The pawpaw nutritional effervescence tablet comprises the following components according to parts by weight: 20 to 80 parts of pawpaw extracting liquid, 5 to 30 parts of vitamin C, 5 to 20 parts of citric acid, 5 to 20 parts of malic acid, 20 to 50 parts of sodium bicarbonate, 5 to 40 parts of dextrin, 1 to 10 parts of polyvidone, 3 to 10 parts of polyethylene glycol, 0.1 to 5 parts of aspartame, 0.1 to 5 parts of microcrystalline cellulose, 0.1 to 5 parts of sodium carboxymethylcellulose and 0.1 to 5 parts of L-leucine; the pawpaw extracting liquid is obtained in such a way that pawpaw after being denucleated and sliced is added with water, ground, pulped, then added with enzymes for hydrolyzing and filtering, and filter liquor is concentrated; the preparation method of the effervescence tablet comprises the following steps: firstly, the pawpaw extracting liquid, the vitamin C, the citric acid, the malic acid, the dextrin and the polyvidone are prepared into acid particles; then, the sodium bicarbonate and the polyethylene glycol are prepared into alkaline particles; finally, the two particles and the rest components are evenly mixed and tabletted to obtain the pawpaw nutritional effervescence tablet; and the effervescence tablet has obvious antioxidation activity, quick disintegration and good mouth feel.
Description
Technical field
The present invention relates to a kind of plant extract preparation, particularly a kind of pawpaw nutritional effervescence tablet also relates to its preparation method.
Background technology
Effervescent tablet is the tablet that contains effervescent, and effervescent is made up of organic acid and weak base, meets waterishlogging and gives birth to neutralization reaction, produces carbon dioxide, thereby makes the rapid disintegrate of tablet.Effervescent tablet is a solid form in production, transportation and storage process, have dosage of solid formulations accurately, steady quality, production automation degree is high, cost is low, be convenient to store and characteristics such as carry; Take facing, have again that liquid preparation is easy to take, onset is rapid, bioavailability is high,, be specially adapted to the patient of child, old people and dysphagia characteristics such as GI irritation property are little with before being made into liquid.In addition, the carbon dioxide that produces during the effervescent tablet disintegrate is partially dissolved in the water, makes the solution inlet that the aesthetic feeling as the soda pop arranged the time, and is refrigerant good to eat.
Fructus Chaenomelis is the fruit of rosaceous plant chaenomeles lagenaria (Chaenomeles), mainly is divided into two big types of wrinkled papaya and Fructus Chaenomelis Chinesiss, and wrinkled papaya mainly contains Fructus Chaenomelis, cloud Fructus Chaenomelis, hides Fructus Chaenomelis and Fructus Chaenomelis japonicae, and Fructus Chaenomelis Chinesis mainly contains mountain papaw.Fructus Chaenomelis is the integration of edible and medicinal herbs article, and it is not good to eat mouthfeel raw, processes the prepared slices of Chinese crude drugs more and uses, and has the effect of suppressing the hyperactive liver Shujin, stomach function regulating removing dampness.Modern study shows that Fructus Chaenomelis contains rich dietary fiber and organic acid, especially contain a large amount of vitamin Cs, polyphenols (comprising chemical compounds such as flavonoid, tannin and phenolic acid) and superoxide dismutase (Superoxide dismutase, SOD).The inventor finds that in previous work Fructus Chaenomelis extract has obvious antioxidation activity, can be used to prepare (CN101444562) such as anti-oxidation health food or medicines.But up to now, do not see the research report of Fructus Chaenomelis extract being processed effervescent tablet both at home and abroad as yet.
Summary of the invention
In view of this, for overcoming the deficiency of prior art, one of the object of the invention is to provide a kind of pawpaw nutritional effervescence tablet; Not only can efficiently, lastingly, stably preserve the antioxidant activity of Fructus Chaenomelis extract; And have and be easy to carry and store, being easy to take, onset is rapid; Characteristics such as bioavailability is high, and mouthfeel is good; Two of the object of the invention is to provide a kind of method for preparing said pawpaw nutritional effervescence tablet, and is easy and simple to handle, process stabilizing, and gained effervescent tablet color and luster is even, surface aesthetic, hardness is suitable, and the effervescent aerogenesis is even, and disintegrate is quick.
For achieving the above object; In first aspect of the present invention; A kind of pawpaw nutritional effervescence tablet is provided, composed of the following components by weight: 0.1～5 part of 20～80 parts of Fructus Chaenomelis extracting solution, 5～30 parts of vitamin Cs, 5～20 parts of citric acids, 5～20 parts of malic acids, 20～50 parts of sodium bicarbonate, 5～40 parts in dextrin, 1～10 part of polyvidone, 3～10 parts of Polyethylene Glycol, 0.1～5 part of aspartame, 0.1～5 part of microcrystalline Cellulose, 0.1～5 part of sodium carboxymethyl cellulose and L-leucine;
Wherein, Fructus Chaenomelis extracting solution prepares by following method:
A, slurrying: after Fructus Chaenomelis enucleation, stripping and slicing, be to add water at 1: 1 to grind, make the Fructus Chaenomelis pulp by the weight ratio of Fructus Chaenomelis sarcocarp and water;
B, enzymolysis: in step a gained Fructus Chaenomelis pulp; Weight ratio by Fructus Chaenomelis pulp and hydrolytic enzyme is 100: 0.2～10 adding hydrolytic enzyme; Be 30～50 ℃ in temperature and be-0.11 with pressure～-carry out enzyme digestion reaction under the condition of 0.09Mpa, the time is 40～90 minutes, makes Fructus Chaenomelis enzymolysis pulp; Said hydrolytic enzyme is cellulase or the compound enzyme be made up of pectase and cellulase;
C, filtration and concentrated: step b gained Fructus Chaenomelis enzymolysis pulp 100 orders are filtered, collect filtrating, be concentrated into 1/2 of cumulative volume, promptly get Fructus Chaenomelis extracting solution.
Further, the proportioning of each component is counted by weight: 0.5～1 part of 30～40 parts of Fructus Chaenomelis extracting solution, 10～15 parts of vitamin Cs, 5～10 parts of citric acids, 5～10 parts of malic acids, 30～40 parts of sodium bicarbonate, 10～20 parts in dextrin, 1～2 part of polyvidone, 5～10 parts of Polyethylene Glycol, 1～2 part of aspartame, 1～2 part of microcrystalline Cellulose, 0.5～1 part of sodium carboxymethyl cellulose and L-leucine;
Further, the proportioning of each component is counted by weight: 1 part of 40 parts of Fructus Chaenomelis extracting solution, 5 parts of vitamin Cs, 5 parts of citric acids, 5 parts of malic acids, 35 parts of sodium bicarbonate, 20 parts in dextrin, 1.5 parts of polyvidones, 8 parts of Polyethylene Glycol, 1.5 parts of aspartames, 1 part of microcrystalline Cellulose, 0.5 part of sodium carboxymethyl cellulose and L-leucine;
Further; The preparation process b of said Fructus Chaenomelis extracting solution is in step a gained Fructus Chaenomelis pulp; Weight ratio by Fructus Chaenomelis pulp and hydrolytic enzyme is the compound enzyme that adding in 100: 2 is made up of pectase and cellulase; Temperature be 40 ℃ with the condition of pressure for-0.09Mpa under carry out enzyme digestion reaction, the time is 60 minutes, makes Fructus Chaenomelis enzymolysis pulp.
In second aspect of the present invention, a kind of method for preparing said pawpaw nutritional effervescence tablet is provided, may further comprise the steps:
A, preparation granulates: using anhydrous alcohol solution to process mass percent concentration the polyvidone of formula ratio is 2% solution; With Fructus Chaenomelis extracting solution, vitamin C, citric acid, malic acid and the dextrin of formula ratio and the povidone solution mix homogeneously that makes, 20～40 purpose granules are processed in spraying;
B, preparation alkali granule: using anhydrous alcohol solution to process mass percent concentration the Polyethylene Glycol of formula ratio is 5% solution; With the sodium bicarbonate of formula ratio and the polyglycol solution mix homogeneously that makes, 20 purpose granules are processed in spraying;
C, tabletting: with aspartame, microcrystalline Cellulose, sodium carboxymethyl cellulose and the L-leucine mix homogeneously of step a gained granulates and step b gained alkali granule and formula ratio, tabletting promptly gets pawpaw nutritional effervescence tablet.
Beneficial effect of the present invention is: the present invention selects suitable adjuvant to fill a prescription and screens and optimization according to the situation such as physicochemical property, biological property and stability of Fructus Chaenomelis extracting solution, and the Fructus Chaenomelis extracting solution that will have remarkable antioxidant activity is processed effervescent tablet; Not only efficiently, lastingly, stably preserved the antioxidant activity of Fructus Chaenomelis extracting solution; Avoid its oxidation or degraded inactivation, and have and be easy to carry and store, be easy to take; Onset is rapid; Advantages such as bioavailability is high, and mouthfeel is good are specially adapted to the patient of child, old people and dysphagia.The method for preparing of effervescent tablet of the present invention is easy, process stabilizing, and favorable reproducibility, gained effervescent tablet color and luster is even, surface aesthetic, hardness is suitable, and the effervescent aerogenesis is even, and disintegrate is quick.
The specific embodiment
In order to make the object of the invention, technical scheme and advantage clearer, will carry out detailed description to the preferred embodiments of the present invention below.
Embodiment 1
1, the preparation of Fructus Chaenomelis extracting solution
A, slurrying: Fructus Chaenomelis is cleaned, after the enucleation, stripping and slicing, is to add water grinding at 1: 1 by the weight ratio of Fructus Chaenomelis sarcocarp and water that making fineness is 100 purpose Fructus Chaenomelis pulps;
B, enzymolysis: in step a gained Fructus Chaenomelis pulp; By the weight ratio of Fructus Chaenomelis pulp and hydrolytic enzyme is that adding by weight ratio at 100: 0.2 is the compound enzyme that 1: 1 pectase and cellulase formed; Under temperature to be 30 ℃, pressure for-0.11Mpa, mixing speed be 180 rev/mins condition, carry out enzyme digestion reaction; Time is 90 minutes, makes Fructus Chaenomelis enzymolysis pulp;
C, filtration and concentrated: step b gained Fructus Chaenomelis enzymolysis pulp 100 orders are filtered, collect filtrating, be concentrated into 1/2 of cumulative volume, promptly get Fructus Chaenomelis extracting solution.
2, the preparation of pawpaw nutritional effervescence tablet
[set of dispense ratio]
Fructus Chaenomelis extracting solution 20g, vitamin C 10g, citric acid 5g, malic acid 5g, sodium bicarbonate 20g, dextrin 5g, polyvidone 1g, Polyethylene Glycol 3g, aspartame 0.1g, microcrystalline Cellulose 0.1g, sodium carboxymethyl cellulose 0.1g and L-leucine 0.1g.
[method for preparing]
A, preparation granulates: using anhydrous alcohol solution to process mass percent concentration the polyvidone of formula ratio is 2% solution; With Fructus Chaenomelis extracting solution, vitamin C, citric acid, malic acid and the dextrin of formula ratio and the povidone solution mix homogeneously that makes, 40 purpose granules are processed in spraying;
B, preparation alkali granule: using anhydrous alcohol solution to process mass percent concentration the Polyethylene Glycol of formula ratio is 5% solution; With the sodium bicarbonate of formula ratio and the polyglycol solution mix homogeneously that makes, 20 purpose granules are processed in spraying;
C, tabletting: with aspartame, microcrystalline Cellulose, sodium carboxymethyl cellulose and the L-leucine mix homogeneously of step a gained granulates and step b gained alkali granule and formula ratio, tabletting promptly gets pawpaw nutritional effervescence tablet.
The pawpaw nutritional effervescence tablet that present embodiment makes, color and luster is even, and certain degree of hardness is arranged, and disintegration meets the requirements, and certain Fructus Chaenomelis local flavor is arranged, and sugariness is lower.
Embodiment 2
1, the preparation of Fructus Chaenomelis extracting solution
A, slurrying: Fructus Chaenomelis is cleaned, after the enucleation, stripping and slicing, is to add water grinding at 1: 1 by the weight ratio of Fructus Chaenomelis sarcocarp and water that making fineness is 100 purpose Fructus Chaenomelis pulps;
B, enzymolysis: in step a gained Fructus Chaenomelis pulp; Weight ratio by Fructus Chaenomelis pulp and hydrolytic enzyme is 100: 6 adding cellulase; Under temperature to be 40 ℃, pressure for-0.10Mpa, mixing speed be 220 rev/mins condition, carry out enzyme digestion reaction; Time is 70 minutes, makes Fructus Chaenomelis enzymolysis pulp;
C, filtration and concentrated: step b gained Fructus Chaenomelis enzymolysis pulp 100 orders are filtered, collect filtrating, be concentrated into 1/2 of cumulative volume, promptly get Fructus Chaenomelis extracting solution.
2, the preparation of pawpaw nutritional effervescence tablet
[set of dispense ratio]
Fructus Chaenomelis extracting solution 30g, vitamin C 15g, citric acid 10g, malic acid 10g, sodium bicarbonate 30g, dextrin 10g, polyvidone 2g, Polyethylene Glycol 5g, aspartame 1g, microcrystalline Cellulose 2g, sodium carboxymethyl cellulose 1g and L-leucine 0.5g.
[method for preparing]
A, preparation granulates: using anhydrous alcohol solution to process mass percent concentration the polyvidone of formula ratio is 2% solution; With Fructus Chaenomelis extracting solution, vitamin C, citric acid, malic acid and the dextrin of formula ratio and the povidone solution mix homogeneously that makes, 30 purpose granules are processed in spraying;
B, preparation alkali granule: using anhydrous alcohol solution to process mass percent concentration the Polyethylene Glycol of formula ratio is 5% solution; With the sodium bicarbonate of formula ratio and the polyglycol solution mix homogeneously that makes, 20 purpose granules are processed in spraying;
C, tabletting: with aspartame, microcrystalline Cellulose, sodium carboxymethyl cellulose and the L-leucine mix homogeneously of step a gained granulates and step b gained alkali granule and formula ratio, tabletting promptly gets pawpaw nutritional effervescence tablet.
The pawpaw nutritional effervescence tablet that present embodiment makes, color and luster is even, surface aesthetic, hardness is better, and disintegrate is rapider, and tangible Fructus Chaenomelis local flavor is arranged, and mouthfeel is better.
Embodiment 3
1, the preparation of Fructus Chaenomelis extracting solution
A, slurrying: Fructus Chaenomelis is cleaned, after the enucleation, stripping and slicing, is to add water grinding at 1: 1 by the weight ratio of Fructus Chaenomelis sarcocarp and water that making fineness is 100 purpose Fructus Chaenomelis pulps;
B, enzymolysis: in step a gained Fructus Chaenomelis pulp; By the weight ratio of Fructus Chaenomelis pulp and hydrolytic enzyme is that adding by weight ratio at 100: 2 is the compound enzyme that 1: 1 pectase and cellulase formed; Under temperature to be 40 ℃, pressure for-0.09Mpa, mixing speed be 200 rev/mins condition, carry out enzyme digestion reaction; Time is 60 minutes, makes Fructus Chaenomelis enzymolysis pulp;
C, filtration and concentrated: step b gained Fructus Chaenomelis enzymolysis pulp 100 orders are filtered, collect filtrating, be concentrated into 1/2 of cumulative volume, promptly get Fructus Chaenomelis extracting solution.
2, the preparation of pawpaw nutritional effervescence tablet
[set of dispense ratio]
Fructus Chaenomelis extracting solution 40g, vitamin C 5g, citric acid 5g, malic acid 5g, sodium bicarbonate 35g, dextrin 20g, polyvidone 1.5g, Polyethylene Glycol 8g, aspartame 1.5g, microcrystalline Cellulose 1g, sodium carboxymethyl cellulose 0.5g and L-leucine 1g.
[method for preparing]
A, preparation granulates: using anhydrous alcohol solution to process mass percent concentration the polyvidone of formula ratio is 2% solution; With Fructus Chaenomelis extracting solution, vitamin C, citric acid, malic acid and the dextrin of formula ratio and the povidone solution mix homogeneously that makes, 20 purpose granules are processed in spraying;
B, preparation alkali granule: using anhydrous alcohol solution to process mass percent concentration the Polyethylene Glycol of formula ratio is 5% solution; With the sodium bicarbonate of formula ratio and the polyglycol solution mix homogeneously that makes, 20 purpose granules are processed in spraying;
C, tabletting: with aspartame, microcrystalline Cellulose, sodium carboxymethyl cellulose and the L-leucine mix homogeneously of step a gained granulates and step b gained alkali granule and formula ratio, tabletting promptly gets pawpaw nutritional effervescence tablet.
The pawpaw nutritional effervescence tablet that present embodiment makes, color and luster is even, and any surface finish is fine and smooth, and hardness is moderate, and disintegrate is rapid, and unique Fructus Chaenomelis local flavor is arranged, sour and sweet palatability, mouthfeel is good.
Embodiment 4
1, the preparation of Fructus Chaenomelis extracting solution
A, slurrying: Fructus Chaenomelis is cleaned, after the enucleation, stripping and slicing, is to add water grinding at 1: 1 by the weight ratio of Fructus Chaenomelis sarcocarp and water that making fineness is 100 purpose Fructus Chaenomelis pulps;
B, enzymolysis: in step a gained Fructus Chaenomelis pulp; By the weight ratio of Fructus Chaenomelis pulp and hydrolytic enzyme is that adding by weight ratio at 100: 2 is the compound enzyme that 1: 1 pectase and cellulase formed; Under temperature to be 40 ℃, pressure for-0.09Mpa, mixing speed be 200 rev/mins condition, carry out enzyme digestion reaction; Time is 60 minutes, makes Fructus Chaenomelis enzymolysis pulp;
C, filtration and concentrated: step b gained Fructus Chaenomelis enzymolysis pulp 100 orders are filtered, collect filtrating, be concentrated into 1/2 of cumulative volume, promptly get Fructus Chaenomelis extracting solution.
2, the preparation of pawpaw nutritional effervescence tablet
[set of dispense ratio]
Fructus Chaenomelis extracting solution 60g, vitamin C 20g, citric acid 15g, malic acid 15g, sodium bicarbonate 40g, dextrin 30g, polyvidone 5g, Polyethylene Glycol 9g, aspartame 2g, microcrystalline Cellulose 4g, sodium carboxymethyl cellulose 2g and L-leucine 3g.
[method for preparing]
A, preparation granulates: using anhydrous alcohol solution to process mass percent concentration the polyvidone of formula ratio is 2% solution; With Fructus Chaenomelis extracting solution, vitamin C, citric acid, malic acid and the dextrin of formula ratio and the povidone solution mix homogeneously that makes, 30 purpose granules are processed in spraying;
B, preparation alkali granule: using anhydrous alcohol solution to process mass percent concentration the Polyethylene Glycol of formula ratio is 5% solution; With the sodium bicarbonate of formula ratio and the polyglycol solution mix homogeneously that makes, 20 purpose granules are processed in spraying;
C, tabletting: with aspartame, microcrystalline Cellulose, sodium carboxymethyl cellulose and the L-leucine mix homogeneously of step a gained granulates and step b gained alkali granule and formula ratio, tabletting promptly gets pawpaw nutritional effervescence tablet.
The pawpaw nutritional effervescence tablet that present embodiment makes, color and luster is even, surface aesthetic, hardness is better, and disintegration is rapider, and the Fructus Chaenomelis local flavor is denseer, and mouthfeel is better.
Embodiment 5
1, the preparation of Fructus Chaenomelis extracting solution
A, slurrying: Fructus Chaenomelis is cleaned, after the enucleation, stripping and slicing, is to add water grinding at 1: 1 by the weight ratio of Fructus Chaenomelis sarcocarp and water that making fineness is 100 purpose Fructus Chaenomelis pulps;
B, enzymolysis: in step a gained Fructus Chaenomelis pulp; By the weight ratio of Fructus Chaenomelis pulp and hydrolytic enzyme is that adding by weight ratio at 100: 10 is the hydrolytic enzyme that 1: 1 pectase and cellulase formed; Under temperature to be 50 ℃, pressure for-0.09Mpa, mixing speed be 250 rev/mins condition, carry out enzyme digestion reaction; Time is 40 minutes, makes Fructus Chaenomelis enzymolysis pulp;
C, filtration and concentrated: step b gained Fructus Chaenomelis enzymolysis pulp 100 orders are filtered, collect filtrating, be concentrated into 1/2 of cumulative volume, promptly get Fructus Chaenomelis extracting solution.
2, the preparation of pawpaw nutritional effervescence tablet
[set of dispense ratio]
Fructus Chaenomelis extracting solution 80g, vitamin C 30g, citric acid 20g, malic acid 20g, sodium bicarbonate 50g, dextrin 40g, polyvidone 10g, Polyethylene Glycol 10g, aspartame 5g, microcrystalline Cellulose 5g, sodium carboxymethyl cellulose 5g and L-leucine 5g.
[method for preparing]
A, preparation granulates: using anhydrous alcohol solution to process mass percent concentration the polyvidone of formula ratio is 2% solution; With Fructus Chaenomelis extracting solution, vitamin C, citric acid, malic acid and the dextrin of formula ratio and the povidone solution mix homogeneously that makes, 40 purpose granules are processed in spraying;
B, preparation alkali granule: using anhydrous alcohol solution to process mass percent concentration the Polyethylene Glycol of formula ratio is 5% solution; With the sodium bicarbonate of formula ratio and the polyglycol solution mix homogeneously that makes, 20 purpose granules are processed in spraying;
C, tabletting: with aspartame, microcrystalline Cellulose, sodium carboxymethyl cellulose and the L-leucine mix homogeneously of step a gained granulates and step b gained alkali granule and formula ratio, tabletting promptly gets pawpaw nutritional effervescence tablet.
The pawpaw nutritional effervescence tablet that present embodiment makes, color and luster is even, surface aesthetic, hardness is bigger, and disintegration meets the requirements, and the Fructus Chaenomelis local flavor is dense, the mouthfeel meta-acid.
Explanation is at last; Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; Although through invention has been described with reference to the preferred embodiments of the present invention; But those of ordinary skill in the art should be appreciated that and can make various changes to it in form with on the details, and the spirit and scope of the present invention that do not depart from appended claims and limited.
Claims (4)
1. pawpaw nutritional effervescence tablet is characterized in that: composed of the following components by weight: 0.5～1 part of 30～40 parts of Fructus Chaenomelis extracting solution, 5～15 parts of vitamin Cs, 5～10 parts of citric acids, 5～10 parts of malic acids, 30～40 parts of sodium bicarbonate, 10～20 parts in dextrin, 1～2 part of polyvidone, 5～10 parts of Polyethylene Glycol, 1～2 part of aspartame, 1～2 part of microcrystalline Cellulose, 0.5～1 part of sodium carboxymethyl cellulose and L-leucine;
Wherein, Fructus Chaenomelis extracting solution prepares by following method:
A, slurrying: after Fructus Chaenomelis enucleation, stripping and slicing, be to add water at 1: 1 to grind, make the Fructus Chaenomelis pulp by the weight ratio of Fructus Chaenomelis sarcocarp and water;
B, enzymolysis: in step a gained Fructus Chaenomelis pulp; Weight ratio by Fructus Chaenomelis pulp and hydrolytic enzyme is 100: 0.2～10 adding hydrolytic enzyme; Be 30～50 ℃ in temperature and be-0.11 with pressure～-carry out enzyme digestion reaction under the condition of 0.09Mpa, the time is 40～90 minutes, makes Fructus Chaenomelis enzymolysis pulp; Said hydrolytic enzyme is cellulase or the compound enzyme be made up of pectase and cellulase;
C, filtration and concentrated: step b gained Fructus Chaenomelis enzymolysis pulp 100 orders are filtered, collect filtrating, be concentrated into 1/2 of cumulative volume, promptly get Fructus Chaenomelis extracting solution.
2. pawpaw nutritional effervescence tablet according to claim 1 is characterized in that: the proportioning of each component is counted by weight: 1 part of 40 parts of Fructus Chaenomelis extracting solution, 5 parts of vitamin Cs, 5 parts of citric acids, 5 parts of malic acids, 35 parts of sodium bicarbonate, 20 parts in dextrin, 1.5 parts of polyvidones, 8 parts of Polyethylene Glycol, 1.5 parts of aspartames, 1 part of microcrystalline Cellulose, 0.5 part of sodium carboxymethyl cellulose and L-leucine.
3. pawpaw nutritional effervescence tablet according to claim 1 and 2; It is characterized in that: the preparation process b of said Fructus Chaenomelis extracting solution is in step a gained Fructus Chaenomelis pulp; Weight ratio by Fructus Chaenomelis pulp and hydrolytic enzyme is the compound enzyme that adding in 100: 2 is made up of pectase and cellulase; Temperature be 40 ℃ with the condition of pressure for-0.09Mpa under carry out enzyme digestion reaction, the time is 60 minutes, makes Fructus Chaenomelis enzymolysis pulp.
4. the method for preparing of the described pawpaw nutritional effervescence tablet of claim 1 is characterized in that: may further comprise the steps:
A, preparation granulates: using anhydrous alcohol solution to process mass percent concentration the polyvidone of formula ratio is 2% solution; With Fructus Chaenomelis extracting solution, vitamin C, citric acid, malic acid and the dextrin of formula ratio and the povidone solution mix homogeneously that makes, 20～40 purpose granules are processed in spraying;
B, preparation alkali granule: using anhydrous alcohol solution to process mass percent concentration the Polyethylene Glycol of formula ratio is 5% solution; With the sodium bicarbonate of formula ratio and the polyglycol solution mix homogeneously that makes, 20 purpose granules are processed in spraying;
C, tabletting: with aspartame, microcrystalline Cellulose, sodium carboxymethyl cellulose and the L-leucine mix homogeneously of step a gained granulates and step b gained alkali granule and formula ratio, tabletting promptly gets pawpaw nutritional effervescence tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910104509XA CN101612221B (en) | 2009-07-31 | 2009-07-31 | Pawpaw nutritional effervescence tablet and preparation method thereof |
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| CN200910104509XA CN101612221B (en) | 2009-07-31 | 2009-07-31 | Pawpaw nutritional effervescence tablet and preparation method thereof |
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| CN101612221B true CN101612221B (en) | 2012-03-21 |
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| CN105231245B (en) * | 2015-11-06 | 2017-12-22 | 四川大学 | A kind of gumbo effervescent tablet and its preparation technology |
| CN105410588B (en) * | 2015-11-06 | 2018-05-08 | 四川兴食尚科技有限公司 | A kind of Kiwi berry effervescent tablet and its preparation process |
| CN107125533A (en) * | 2017-06-09 | 2017-09-05 | 合肥工业大学 | A kind of preparation method of Xuancheng's pawpaw effervescent tablet |
| CN107753459A (en) * | 2017-10-26 | 2018-03-06 | 安徽世龙生物医药科技有限公司 | A kind of vitamin C effervescent tablet and preparation method thereof |
| CN112007008A (en) * | 2020-08-14 | 2020-12-01 | 新食代布丁(上海)智能科技有限公司 | Multi-taste elderberry effervescent tablet and preparation method thereof |
| CN112056531A (en) * | 2020-09-21 | 2020-12-11 | 广东食品药品职业学院 | Aloe, pawpaw and honey effervescent granule and preparation method thereof |
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