CN101590171B - Chinese medicinal composition for treating acute ankle sprain - Google Patents
Chinese medicinal composition for treating acute ankle sprain Download PDFInfo
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- CN101590171B CN101590171B CN2009103043807A CN200910304380A CN101590171B CN 101590171 B CN101590171 B CN 101590171B CN 2009103043807 A CN2009103043807 A CN 2009103043807A CN 200910304380 A CN200910304380 A CN 200910304380A CN 101590171 B CN101590171 B CN 101590171B
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Abstract
The invention relates to a Chinese medicinal composition for treating acute ankle sprain and relates to a Chinese medicinal composition which is prepared from the following Chinese herbal medicament materials in portion by weight: 3.3 to 7 portions of notoginseng, 3.3 to 7 portions of paris, 20 to 40 portions of rhizoma cibotii, 30 to 50 portions of epimedium, 10 to 20 portions of pubescent angelica, 20 to 40 portions of dipsacus, 20 to 40 portions of southern mistletoe, 30 to 80 portions of cooked rehmannia, 8 to 12 portions of costusroot, 10 to 20 portions of frankincense, 10 to 20 portions of myrrh, 3.3 to 13 portions of prepared aconitum vilmorinianum, 6.6 to 20 portions of baical skullcap root -, 6.6 to 13 portions of acorus, 0.66 to 2 portions of dactylicapnos root, 3.3 to 6.6 portions of delavay ampelopsis root, 6.6 to 20 portions of bleeding tree, 3.3 to 6.6 portions of falcate dolichos root, 2 to 3.3 portions of psammosilene and 3.3 to 5 portions of large gentian. The Chinese medicinal composition can remove the pathological change of articular trauma and promote rapid and good rehabilitation of wound tissues and has the advantages of rapid effect, short treatment course, good comprehensive treatment effect, convenient taking, safety, reliability and the like.
Description
[technical field]:
The present invention relates to a kind of Chinese medicine composition, particularly a kind of Chinese medicine composition for the treatment of acute ankle sprain.
[background technology]:
Acute ankle sprain is common, the most multiple damage in daily life, military training, sports, account for the first place of each articular sprain of whole body, thereby patient is a lot of.This type of sprain many since walking accidentally or the motion unstability cause foot to turn in taking place suddenly or turn up, damage comprises that the joint surrounding tissue of ligament forms.And ankle joint as human lower limb walk, movable topmost, unique organ of bearing a heavy burden of landing is extremely important, treating not, science easily causes ligament to be difficult for healing, dislocation of ankle joint decline, but illness such as amyotrophy around the secondary ankle joint, ankle joint inner impact, ankle joint osteoarthritis influence the basic function of Ambulatory Activity.Because it often damages and can not take a turn for the better in the short time, recovers its walking, movable function, bring the deuce to pay for life, the allegro modern of work.Therefore extensive patients (particularly sport people) presses for a kind of short treating period, the novel drugs of instant effect based on current demand.Traumatic surgery studies show that wound tissue's reparation needs the filling of experience fibrin, hyperplasia, organizes moulding three stages.Fibrin filling, histiocyte hypertrophy have just appearred as far back as the inflammatory reaction phase.Through hyper-proliferative, wound can tentatively heal.Because physiological function needs, also need be moulding through organizing, make function near normal.The cytothesis wound that do as one likes matter is identical, it is good that the function ratio scar tissue is repaired.Therefore wound is striven for early stage primary healing, reduces scar tissue and substitutes repairing the wound adverse effect, and functional rehabilitation just has promising result.
At present, the medicine of acute ankle sprain is had two kinds of external used medicine and oral drugs, external used medicine can be used for pain relieving, but because most of external used medicine all is to adopt the mode of washing, pasting to treat, complicated operation, and want the special messenger to implement, holding time is many.And because the existence of physiologic barrier such as skin, external used medicine is few by the amount that enters intralesional outward, and site of action is shallow, and produce effects is slow, can not absorb ankle joint wound focus, repair have clearly, very fast therapeutical effect.
Oral drugs can make the through wound tissue of drug effect depths performance therapeutical effect, and are simple, convenient, can accept for extensive patients.Usually oral drugs comprise pain relieving class medicine, blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral class Chinese patent medicine etc., but pain relieving class medicine can only be used to alleviate the symptomatic treatment of disease; Blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral class Chinese patent medicine such as commercially available ZHONGHUA DIEDA WAN, in acute ankle sprain (being that blood stasis dissipates the phase) use after 72 hours, can play and eliminate local lesion's blood stasis, promote inflammation material absorbing, analgesic effect, for condition has been created in the reparation of human body wound tissue,, actual tissue repair carries out but will waiting for the function of repairing naturally of body quietly.Therefore its treatment lags behind opportunity, repairs slowly, and the course of treatment is longer, and wound tissue's hyperplasia reparation is less relatively.
[summary of the invention]:
The technical problem to be solved in the present invention is: the Chinese medicine composition that the good treatment acute ankle sprain of a kind of instant effect, short treating period, comprehensive therapeutic effect is provided.
The technical scheme that solves the problems of the technologies described above is: a kind of Chinese medicine composition for the treatment of acute ankle sprain is characterized in that: the Chinese medicine composition of this treatment acute ankle sprain mainly is to be made by the herbal raw material of following parts by weight proportioning:
Radix Notoginseng 3.3-7, Rhizoma Paridis 3.3-7, Rhizoma Cibotii 20-40, Herba Epimedii 30-50, Radix Angelicae Pubescentis 10-20,
Radix Dipsaci 20-40, Herba Taxilli 20-40, Radix Rehmanniae Preparata 30-80, Radix Aucklandiae 8-12, Olibanum 10-20,
Myrrha 10-20, manufacture-yellow Radix Aconiti Kusnezoffii 3.3-13, Radix Scutellariae 6.6-20, Rhizoma Acori Graminei 6.6-13,
Radix dactylicapni (Radix Dactylicapnotis) 0.66-2, Delavay ampelopsis root 3.3-6.6, Pseudostreblus indica Bur. 6.6-20, Radix seu Cortex Heteropanacis 3.3-6.6,
Radix Psammosilenes 2-3.3, Radix Gentianae Macrophyllae 3.3-5.
Further technical scheme of the present invention is: the Chinese medicine composition of this treatment acute ankle sprain mainly is to be made by the herbal raw material of following parts by weight proportioning:
Radix Notoginseng 5-6, Rhizoma Paridis 5-6, Rhizoma Cibotii 30-35, Herba Epimedii 40-45, Radix Angelicae Pubescentis 15-18,
Radix Dipsaci 30-35, Herba Taxilli 30-35, Radix Rehmanniae Preparata 50-60, Radix Aucklandiae 9-10, Olibanum 15-18,
Myrrha 15-18, manufacture-yellow Radix Aconiti Kusnezoffii 8-10, Radix Scutellariae 10-15, Rhizoma Acori Graminei 8-10,
Radix dactylicapni (Radix Dactylicapnotis) 1-1.5, Delavay ampelopsis root 4.5-5.5, Pseudostreblus indica Bur. 10-15, Radix seu Cortex Heteropanacis 4.5-5.5,
Radix Psammosilenes 2.5-3, Radix Gentianae Macrophyllae 4-4.5.
The preferred weight umber proportioning of the above-mentioned Chinese herbal medicine of respectively distinguishing the flavor of is:
Radix Notoginseng 5, Rhizoma Paridis 5, Rhizoma Cibotii 30, Herba Epimedii 40, Radix Angelicae Pubescentis 15,
Radix Dipsaci 30, Herba Taxilli 30, Radix Rehmanniae Preparata 55, the Radix Aucklandiae 10, Olibanum 15,
Myrrha 15, manufacture-yellow Radix Aconiti Kusnezoffii 8, Radix Scutellariae 15, Rhizoma Acori Graminei 10, Radix dactylicapni (Radix Dactylicapnotis) 1.5,
Delavay ampelopsis root 5, Pseudostreblus indica Bur. 15, Radix seu Cortex Heteropanacis 5, Radix Psammosilenes 2.6, Radix Gentianae Macrophyllae 4.
The dosage form of the Chinese medicine composition of this treatment acute ankle sprain is capsule, tablet, pill, granule or oral liquid.
The nature and flavor and the effect of the Chinese herbal medicine of respectively distinguishing the flavor of that the present invention is selected cure mainly as follows:
(1), Radix Notoginseng: call become civilized Radix Notoginseng, Panax pseudoginseng, Radix Notoginseng, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Rhizoma Bergeniae scopulosae.
Nature and flavor: sweet and slightly bitter taste, warm in nature,
Effect with cure mainly: have dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain cures mainly spitting of blood, spits blood, and epistaxis is had blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling down swells and ache.
(2), Rhizoma Paridis: another name Rhizoma Paridis, Chong Tai, careless Radix Kansui.
Nature and flavor: toil, cold.
Effect with cure mainly: heat-clearing and toxic substances removing, antiasthmatic-antitussive, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.Cure mainly carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, infantile convulsion is twitched, snake bite and insect sting.
(3), Rhizoma Cibotii: another name Rhizoma Cibotii, Cibotium barometz (L.) J. Sm., golden Rhizoma Cibotii, gold hair lion, monkey burr, yellow dog head.
Nature and flavor: bitter, sweet, temperature.
Effect with cure mainly: have wind-damp dispelling, invigorating the liver and kidney, the effect of strong waist knee joint cures mainly rheumatic arthralgia, soreness of the waist and knees, the muscles and bones contraction is anxious, extremity are meciless.
(4), Herba Epimedii: another name Herba Epimedii, Herba Epimedii, celestial spirit are adjoined.
Nature and flavor: hot, sweet, temperature.Return liver, kidney channel.
Effect with cure mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
(5), Radix Angelicae Pubescentis: solely shake grass, solely slide Sempervivum tectorum.
Nature and flavor: arduous, temperature.Dispel the wind, win and wet, cold expelling, pain relieving.
Effect with cure mainly: control anemofrigid-damp arthralgia, soreness of waist and knee joint, the trick spasm and pain, chronic tracheitis, the headache, toothache.
(6), Radix Dipsaci: another name Radix Dipsaci, shaven head, chervil, Radix Dipsaci.
Nature and flavor: bitter, hot, tepor.
Effect with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered, and ends metrorrhagia.Be used for soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia more, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees more.
(7), Herba Taxilli: parasitic on another name parasitism, the Mulberry.
Nature and flavor: bitter, sweet, flat.Return liver, kidney channel.
Effect with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.Be used for rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and the metrorrhagia warp is many, blood leaking in gestation, frequent fetal movement; Hypertension.
(8), Radix Rehmanniae Preparata: the another name Radix Rehmanniae Preparata, throw oneself on the ground, wine pot flower, mountain cigarette, Chinese cabbage.
Nature and flavor: sweet in the mouth, slightly warm in nature.
Effect with cure mainly: have the YIN nourishing of enriching blood effect, be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, diseases such as metrorrhagia.
(9), the Radix Aucklandiae: another name Saussurea lappa Clarke, honey perfume, Radix Aristolochiae, Radix Aristolochiae yunnanensis, Radix Aucklandiae (Radix Vladimiriae).
Nature and flavor: hot, bitter, temperature.
Effect with cure mainly: a, promoting the circulation of QI to relieve pain are used for abdominal distention, lack of appetite vomiting due to the stagnation of QI in spleen and stomach;
B, regulate the flow of vital energy soothing the liverly, be used for the hypochondriac pain that QI stagnation of the liver and galibladder causes; C, spleen invigorating disappear stagnant, the adjustable gastrointestinal gas that stagnates.Treatment stomachache, diarrhoea, tenesmus.
(10), Olibanum:
Nature and flavor: hot, bitter, temperature.
Effect with cure mainly: regulating QI, invigorate blood circulation, pain relieving chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
(11), Myrrha: another name myrrh, bright Myrrha.
Meridian distribution of property and flavor: hardship, suffering, flat.
Effect with cure mainly: the blood blood stasis removing that looses, subduing swelling and relieving pain.Control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.
(12), manufacture-yellow Radix Aconiti Kusnezoffii: another name Radix Aconiti Vilmoriniani.
Nature and flavor: toil fiber crops, temperature, severe toxicity (not concocting).
Effect with cure mainly: expelling wind and cold, removing damp and stopping pain.
(13), Radix Scutellariae: another name Radix Scutellariae, scutellaria tea, tsuchikane tea root.
Nature and flavor: hardship, cold.
Effect with cure mainly: heat clearing and damp drying, eliminating fire and detoxication, the hemostasis, antiabortive.Be used for hygropyrexia, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat is collapsed, is leaked, and heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
(14), Rhizoma Acori Graminei: another name Chang Pu, powder Chang.
Nature and flavor: suffering, tepor.
Effect with cure mainly: have one's ideas straightened out, eliminating phlegm is regulated the flow of vital energy, and invigorates blood circulation, and the wind that looses dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.
(15), Radix dactylicapni (Radix Dactylicapnotis): the black Radix Achyranthis Bidentatae of another name, mountain, river seven, string branch lotus, Semen Pisi sativi traumatic injury, Radix seu Cortex Heteropanacis, Semen Pisi sativi seven.
Nature and flavor: hot, bitter, cold.
Effect with cure mainly: pain relieving, blood pressure lowering, the hemostasis.Control various pain, hypertension, metrorrhagia, hemorrhage due to internal injury, traumatic injury.
(16), Delavay ampelopsis root: another name Radix Ampelopsis delavayanae, JIANZHONGXIAO, red Pueraria lobota.
Nature and flavor: hot, flat.
Effect with cure mainly: dispelling, collateral-activating, subduing swelling and detoxicating, hemostasis and pain-relieving, evacuation of pus granulation promoting, wind-damp dispelling.Control traumatic injury, fracture, rheumatic arthritis, rheumatic lumbago and scelalgia is had blood in stool, metrorrhagia, leucorrhea.
(17), Pseudostreblus indica Bur.: the blue or green tree of another name traumatic injury, hemostasis tree.
Nature and flavor: bitter, hot, temperature.
Effect with cure mainly: the hemostasis, pain relieving.Be used for digestive tract hemorrhage, stomachache; Traumatic hemorrhage is controlled in external.
(18) Radix seu Cortex Heteropanacis: fiber crops, sickleleaf Herba Cassiae Mimosoidis in the another name fiber crops
Nature and flavor: suffering, temperature.
Effect with cure mainly: expelling wind and activating blood circulation, hemostasis and pain-relieving.Be used for fracture, traumatic injury, rheumatalgia; Traumatic hemorrhage is controlled in external.
(19), Radix Psammosilenes: call only nail, RADIX PSAMMOSILENE, Kunming Radix Adenophorae (Radix Glehniae), Pachysandra axillaris Franch., to leaf seven, Baima divide hair on the neck, solely the Cornu Cervi Rhizoma Zingiberis Recens, shoot with great precision, Chuan Shijia, Rhizoma cypripedii macranthi.
Nature and flavor: suffering, temperature.
Effect cures mainly: expelling wind and activating blood circulation, eliminating stasis to stop pain.Be used for traumatic injury, rheumatalgia, stomachache; Wound hemorrhage is controlled in external.
(20), Radix Gentianae Macrophyllae: another name Flos Cannabis Macrophylla, radix gentiane dahuvicae, Radix Gentianae Marcrophyllae, western Radix Gentianae Marcrophyllae, a left side are turned round, twist on a left side, RADIX GENTIANAE MACROPHYLLAE, RADIX GENTIANAE MACROPHYLLAE, Radix Raphani Macrophylla, plait Macrophylla.
Nature and flavor: hot, bitter, flat.
Effect with cure mainly: wind-damp dispelling, clearing away damp-heat, stopping numbness pain.Be used for rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, infantile malnutrition heating.
Motherland's orthopedics and traumatology of Chinese medicine have the Therapeutic Principle of " blood stasis dispelling is set upright ", the applicant is according to this Therapeutic Principle and in conjunction with practising medicine for many years and scientific research cognition, develop and to eliminate the Chinese medicine composition that the articular trauma pathological change can promote the present invention's that wound tissue repairs treatment acute ankle sprain again faster and betterly, the Chinese medicine composition of this treatment acute ankle sprain is compared with the medicine of existing treatment acute ankle sprain, has following beneficial effect:
1, instant effect, short treating period:
Because the present invention has adopted and has been used to sprain early stage hemostasis dissipating blood stasis apoplexy due to endogenous wind medical herbs, as Radix Notoginseng, Olibanum, Myrrha, manufacture-yellow Radix Aconiti Kusnezoffii, Radix Scutellariae, Rhizoma Acori Graminei, Radix dactylicapni (Radix Dactylicapnotis), Delavay ampelopsis root, Pseudostreblus indica Bur., Radix seu Cortex Heteropanacis, Radix Psammosilenes, it is partial hemorrhage to stop damage, local stasis of blood can dissipate again, the acceleration blood clot is removed, promote blood capillary that protein solution in tract, the interstice is absorbed, improve blood circulation, the draining detumescence; Impose simultaneously liver and kidney tonifying class Chinese herbal medicine again, as Rhizoma Cibotii, Herba Epimedii, Radix Angelicae Pubescentis, Herba Taxilli, Radix Dipsaci, Radix Rehmanniae Preparata, the Radix Aucklandiae, this class Chinese herbal medicine has antiinflammation, can reduce content of material such as prostate E in the inflammation kitchen range, and the effect of corticoid sample arranged, be beneficial to the local inflammation reaction of disappearing, reduce tissue fluid and ooze out, to reach the purpose that alleviates early stage swelling; In addition, the Chinese herbal medicine of this class liver and kidney tonifying can promote protein biology synthetic, improve substance metabolism, increase energy and generate, transform and store, improve body physiological function comprehensively, can not only make histoorgan that sufficient power is arranged, promote to repair damage, promote that inflammatory reaction phase at wound initial stage fibrin is filled, the histiocyte hypertrophy, shortening injury ligament etc. is organized preliminary healing time, can promote that also body function is compensatory.Thereby the affected part function rebuild as soon as possible, near normal.
Therefore, the present invention's dissipating blood stasis apoplexy due to endogenous wind medical herbs that will stop blooding mixes in scientific and reasonable ratio mutually with liver and kidney tonifying class Chinese herbal medicine, can in time stop local hemorrhage, removes hematocele, control inflammatory exudation, draining detumescence; Can support to repair wounded tissue around the joint that comprises ligament again early, carry out simultaneously two aspects, instant effect not only, and show through clinical comparison, its analgesic effect is good than ZHONGHUA DIEDA WAN, and healing time only is 4.62 ± 1.92 days, and the healing time of ZHONGHUA DIEDA WAN needs 17.2 ± 0.53 days, therefore, shortened greatly the course of treatment of the present invention.
2, comprehensive therapeutic effect is good:
Through a large amount of studies show that of the applicant, the Chinese medicine composition of the present invention's treatment acute ankle sprain has good reducing swelling and alleviating pain, reparation wound, recovers the effect of function of joint, and its comprehensive therapeutic effect is good.
3, taking convenience, worth clinical expansion.
Because the present invention can be made into dosage forms such as capsule, tablet, pill, granule or oral liquid, take very conveniently, be worth clinical expansion.
It is 4, safe and practical, reliable,
The drug dose of the Chinese medicine composition of the present invention's treatment acute ankle sprain, usage are all used by " practical Chinese medicine toxicology " requirement, and medicine LD50 value has been determined in the acute or chronic toxicity test check of most of oral administration administration; The southern autochthonal Chinese medicine of parts such as manufacture-yellow Radix Aconiti Kusnezoffii, Radix dactylicapni (Radix Dactylicapnotis), Delavay ampelopsis root, Pseudostreblus indica Bur., Radix seu Cortex Heteropanacis, Radix Psammosilenes uses according to " Chinese medicine voluminous dictionary ", more than mixed capsule, pill, tablet, granule or the oral liquid made of all medicines, all do not implement the chemical reaction course of processing, take as safe as a house, reliable.
In addition, the Chinese medicine composition of the present invention's treatment acute ankle sprain can also be used for the treatment of other joint injury, arthritis, soft tissue injury or fracture.
Below, the technical characterictic to the Chinese medicine composition of the present invention's treatment acute ankle sprain is further described in conjunction with the embodiments.
[specific embodiment]:
Embodiment one:
A kind of Chinese medicine composition for the treatment of acute ankle sprain, it is to be made by the herbal raw material of following parts by weight proportioning:
Radix Notoginseng 5g, Rhizoma Paridis 5g, Rhizoma Cibotii 30g, Herba Epimedii 40g, Radix Angelicae Pubescentis 15g,
Radix Dipsaci 30g, Herba Taxilli 30g, Radix Rehmanniae Preparata 55g, Radix Aucklandiae 10g, Olibanum 15g,
Myrrha 15g, manufacture-yellow Radix Aconiti Kusnezoffii 8g, Radix Scutellariae 15g, Rhizoma Acori Graminei 10g, Radix dactylicapni (Radix Dactylicapnotis) 1.5g,
Delavay ampelopsis root 5g, Pseudostreblus indica Bur. 15g, Radix seu Cortex Heteropanacis 5g, Radix Psammosilenes 2.6g, Radix Gentianae Macrophyllae 4g.
With above-mentioned respectively distinguish the flavor of formula material routinely technology be ground into medicated powder and incapsulate, every heavy 1.625g.
Instructions of taking: oral 4, every day 2 times, each 1 of child, oral, every day 2 times.
Points for attention: the careful usefulness of hepatic disfunction person is not taken by pregnant women.The hemorrhage forbidding that blood minimizing purpura and hematopathy cause, foods such as period in a medicine diet Semen Viciae fabae, buckwheat, acid and Fish.
Embodiment two:
A kind of Chinese medicine composition for the treatment of acute ankle sprain, it is to be made by the herbal raw material of following parts by weight proportioning:
Radix Notoginseng 3.3g, Rhizoma Paridis 3.3g, Rhizoma Cibotii 20g, Herba Epimedii 30g, Radix Angelicae Pubescentis 10g,
Radix Dipsaci 20g, Herba Taxilli 20g, Radix Rehmanniae Preparata 30g, Radix Aucklandiae 8g, Olibanum 10g,
Myrrha 10g, manufacture-yellow Radix Aconiti Kusnezoffii 3.3g, Radix Scutellariae 6.6g, Rhizoma Acori Graminei 6.6g, Radix dactylicapni (Radix Dactylicapnotis) 0.66g,
Delavay ampelopsis root 3.3g, Pseudostreblus indica Bur. 6.6g, Radix seu Cortex Heteropanacis 3.3g, Radix Psammosilenes 2g, Radix Gentianae Macrophyllae 3.3g.
With above-mentioned respectively distinguish the flavor of formula material routinely the technology powder make tablet, every heavy 0.813g.
Instructions of taking: oral 4, every day 2 times, the each 1-2 sheet of child, oral, every day 2 times.
Points for attention: the careful usefulness of hepatic disfunction person is not taken by pregnant women.The hemorrhage forbidding that blood minimizing purpura and hematopathy cause, foods such as period in a medicine diet Semen Viciae fabae, buckwheat, acid and Fish.
Embodiment three:
A kind of Chinese medicine composition for the treatment of acute ankle sprain, it is to be made by the herbal raw material of following parts by weight proportioning:
Radix Notoginseng 7g, Rhizoma Paridis 7g, Rhizoma Cibotii 40g, Herba Epimedii 50g, Radix Angelicae Pubescentis 20g,
Radix Dipsaci 40g, Herba Taxilli 40g, Radix Rehmanniae Preparata 80g, Radix Aucklandiae 12g, Olibanum 20g,
Myrrha 20g, manufacture-yellow Radix Aconiti Kusnezoffii 13g, Radix Scutellariae 20g, Rhizoma Acori Graminei 13g, Radix dactylicapni (Radix Dactylicapnotis) 2g,
Delavay ampelopsis root 6.6g, Pseudostreblus indica Bur. 20g, Radix seu Cortex Heteropanacis 6.6g, Radix Psammosilenes 3.3g, Radix Gentianae Macrophyllae 5g.
With above-mentioned respectively distinguish the flavor of formula material routinely technology make pill, every heavy 1.625g.
Instructions of taking: oral 4, every day 2-3 time; The each 1-2 grain of child, oral, every day 2 times.
Points for attention: the careful usefulness of hepatic disfunction person is not taken by pregnant women.The hemorrhage forbidding that blood minimizing purpura and hematopathy cause, foods such as period in a medicine diet Semen Viciae fabae, buckwheat, acid and Fish.
Embodiment four～embodiment ten
The Chinese medicine composition of the treatment acute ankle sprain that various component content are different, the parts by weight proportioning of the herbal raw material of respectively distinguishing the flavor of among each embodiment is shown in subordinate list one.
As a kind of conversion of embodiment one to embodiment ten, each proportioning raw materials of the Chinese medicine composition of described treatment acute ankle sprain can increase or reduce, and each raw material is to carry out proportioning by following parts by weight generally speaking:
Radix Notoginseng 3.3-7, Rhizoma Paridis 3.3-7, Rhizoma Cibotii 20-40, Herba Epimedii 30-50, Radix Angelicae Pubescentis 10-20,
Radix Dipsaci 20-40, Herba Taxilli 20-40, Radix Rehmanniae Preparata 30-80, Radix Aucklandiae 8-12, Olibanum 10-20,
Myrrha 10-20, manufacture-yellow Radix Aconiti Kusnezoffii 3.3-13, Radix Scutellariae 6.6-20, Rhizoma Acori Graminei 6.6-13,
Radix dactylicapni (Radix Dactylicapnotis) 0.66-2, Delavay ampelopsis root 3.3-6.6, Pseudostreblus indica Bur. 6.6-20, Radix seu Cortex Heteropanacis 3.3-6.6,
Radix Psammosilenes 2-3.3, Radix Gentianae Macrophyllae 3.3-5.
As another conversion of embodiment one to embodiment ten, the best ratio range of each raw material of the Chinese medicine composition of described treatment acute ankle sprain is to carry out proportioning by following parts by weight:
Radix Notoginseng 5-6, Rhizoma Paridis 5-6, Rhizoma Cibotii 30-35, Herba Epimedii 40-45, Radix Angelicae Pubescentis 15-18,
Radix Dipsaci 30-35, Herba Taxilli 30-35, Radix Rehmanniae Preparata 50-60, Radix Aucklandiae 9-10, Olibanum 15-18,
Myrrha 15-18, manufacture-yellow Radix Aconiti Kusnezoffii 8-10, Radix Scutellariae 10-15, Rhizoma Acori Graminei 8-10,
Radix dactylicapni (Radix Dactylicapnotis) 1-1.5, Delavay ampelopsis root 4.5-5.5, Pseudostreblus indica Bur. 10-15, Radix seu Cortex Heteropanacis 4.5-5.5,
Radix Psammosilenes 2.5-3, Radix Gentianae Macrophyllae 4-4.5.
As another conversion of embodiment one to embodiment ten, the Chinese medicine composition of described treatment acute ankle sprain can be made capsule, tablet, pill, granule or oral liquid.
Subordinate list one: the herbal raw material proportioning catalog of the Chinese medicine composition of embodiment four～embodiment ten described treatment acute ankle sprains (calculating) with parts by weight
The test example:
The present invention is used for the treatment of the clinical trial of acute ankle sprain:
Curative effect for the Chinese medicine composition of the treatment acute ankle sprain of verifying the present invention, the inventor has carried out clinical trial to its treatment acute ankle sprain, and with ZHONGHUA DIEDA WAN [Guangxi Wuzhou Pharmaceutical (group) limited company, the 6g/ grain, lot number Z45020316] observe in contrast, further investigate its clinical efficacy and safety.The result is as follows:
1, clinical data
1.1 physical data:
All case is the traditional Chinese medical science orthopaedics out-patient of section of the east of a river, Liuzhou People's Hospital branch, 67 routine patients are divided into treatment group and matched group at random, and physical data such as 2 groups of patient's sexes, age are learned by statistics and handled P＞0.05, difference not statistically significant, have comparability, see attached list two.
Subordinate list two acute ankle sprain of ankle patient physical data
P＞0.05
1.2 diagnostic criteria
With reference to the diagnosis requirement of primary disease in " clinical bone injury science ", draft diagnostic criteria: 1. obvious sprained ankle history is arranged; 2. ankle swells and ache after hindering, movable difficulty; 3. ankle swelling, ecchymoma, the dropping walking that maybe can not land, the colour of skin is livid purple, local tenderness; 4. turn in the ankle joint or the valgus test positive; 5. the X ray examination does not have fracture, displacement sign.
1.3 the standard of including in
Meet above-mentioned diagnostic criteria, body temperature＜37.5 ℃ person all can include this research in.
1.4 exclusion standard
Thrombocytopenic purpura patient; The anemia of pregnant woman; Be associated with disease patients such as rheumatic arthritis, rheumatoid arthritis and liver and hemopoietic system.
2, medicine
2.1 treatment group
The Chinese medicine composition of the present invention's treatment acute ankle sprain, capsule, the 1.625g/ grain, 6.5g is oral, and every day 2 times, 4 days is a course of treatment.
2.2 matched group
ZHONGHUA DIEDA WAN (Guangxi Wuzhou Pharmaceutical (group) limited company, 6g/ grain, lot number Z45020316), 6g is oral, and every day 2 times, 4 days is a course of treatment.
Above-mentioned 2 groups the treatment during require the patient to lie up, raise the trouble limb, joint immobilization, 2 groups all treat 1 course of treatment after, the statistics curative effect.
2.3 statistical procedures
The efficacy evaluation rank test.Pain scores relatively, with in the group and t check between group.Healing time is relatively checked with t between group, data mean ± standard deviation (X ± S) expression.
3 observation of curative effect
3.1 observation index
(1) record patient whole body and partial symptom and sign.
(2) pain integration scoring: 6 behavior scoring methods that employing Budzyuski recommends (Li Zhonglian. clinical pain therapy is learned [M]. and Tianjin: Tianjin science tech publishing house 1994:386), is divided into 6 grades with pain: 0 minute, no pain; 1 minute, pain is arranged; But can be ignored easily; 2 minutes, pain is arranged, can't ignore, do not disturb daily life; 3 minutes, pain is arranged, can't ignore disturbance of concentration; 4 minutes, pain is arranged, can't ignore, all daily routines are all influenced, but can finish the basic physiological demand as feed and defecation etc.; 5 minutes, existence had an intense pain, and can't ignore, and needed to have a rest or lie up.
(3) mensuration of treatment time promptly writes down the treating time process after the treatment beginning.
3.2 efficacy assessment standard
" disease of tcm diagnosis criterion of therapeutical effect " according to State Administration of Traditional Chinese Medicine's issue formulates criterion of therapeutical effect.Cure: ankle joint disappearances of swelling and ache, the joint is stable, and movable function recovers normally; Take a turn for the better: arthralgia alleviates, mild swelling or ecchymosis, and owe surely in the joint, and walking is weak aches; Do not heal: ankle joint pain does not have improvement, limitation of activity.
3.3 therapeutic outcome
(1) 2 group of patient's clinical efficacy relatively sees attached list three
By subordinate list three as seen, 2 groups of curative effects compare, and it is better that difference has statistical significance (P＜0.01) prompting treatment group curative effect.
Pain scores relatively sees attached list four before and after (2) 2 groups of patient treatments.
By subordinate list four as seen, relatively, difference has statistical significance (P＜0.01) before and after 2 groups of patient's pain scores treatments; And treatment back treatment group and matched group are relatively, and difference also has statistical significance (P＜0.01); The analgesic effect of prompting treatment group is better.
(3) 2 groups of patient's healing times relatively see attached list five
By subordinate list five as seen, 2 groups of healing times compare, and difference has statistical significance (P＜0.01) prompting treatment group, and treatment has short treating period, the good advantage of curative effect than matched group to primary disease.
32 groups of acute ankle sprain patients of subordinate list clinical efficacy comparative example (%)
| Group | The example number | Cure | Take a turn for the better | Do not heal | Effective percentage (%) |
| The treatment group | 38 | 29(76.31) | 8(21.05) | 1(2.6) | 97.4 |
| Matched group | 29 | 10(34.48) | 12(41.38) | 7(24.14) | 75.86 |
Pain scores comparison before and after 42 groups of acute ankle sprain patient treatments of subordinate list (X ± s)
| Group | The example number | Before the treatment | After the treatment | P |
| The treatment group | 38 | 3.92±0.49 | 1±0.92 | ＜0.01 |
| Matched group | 39 | 3.69±1.0 | 2.17±1.66 | ＜0.01 |
| P | ＞0.05 | ＜0.01 |
The comparison of 52 groups of acute ankle sprain patients of subordinate list healing time (X ± S)
| Group | The example number | Healing time (my god) |
| The treatment group | 38 | 4.62±1.92 |
| Matched group | 29 | 17.2±0.53 |
| P | ＜0.01 |
4, discuss:
Above-mentioned clinical test results shows that the Chinese medicine composition of the present invention's treatment acute ankle sprain is used for the treatment of acute ankle sprain, has the effect of good reducing swelling and alleviating pain, reparation wound, recovery function of joint.2 groups of analgesic effects compare (P＜0.01); 2 groups of healing time length compare (P＜0.01), illustrate that the present invention has the good curing rehabilitative action.In sum, the Chinese medicine composition of the present invention's treatment acute ankle sprain is used for the treatment of acute ankle sprain and has instant effect, short treating period, is easy to implement, safe and practical, reliable advantage, is worth clinical expansion.
Model case:
1, XX not, woman, 24 years old, Liuzhou Digit Control Machine Tool institute office worker.Examine in June, 2009, right swollen ankles, and pain is difficult sleeping, and is movable unfavorable, and pain behavior scoring method evaluation in 6 o'clock pain degree is 4 minutes.Plan is diagnosed as right sprain of ankle 2 degree, takes above-mentioned Chinese medicine composition.Took medicine the 4th day, the basic disappearance of swelling and ache, joint motion is normal.
2, Zou X, the man, 34 years old, Liuzhou Chengzhong District people, in April, 2009 is because of the motion left ankle joint of causing injury, local swelling, left ankle skin has large stretch of stasis of blood purpura, has an intense pain, and can not walk, and pain behavior scoring method evaluation in 6 o'clock pain degree is 5 minutes.Plan is diagnosed as " left sprain of ankle 2 degree ".Take above-mentioned Chinese medicine composition after 2 days pain scores be 2 minutes, swelling disappears after 5 days, skin is deposited a little pale purple speckle, ankle joint does not have obvious pain, joint motion is stable normal.So far left ankle joint does not have sense of discomfort.
Claims (5)
1. Chinese medicine composition for the treatment of acute ankle sprain, it is characterized in that: the Chinese medicine composition of this treatment acute ankle sprain is to be made by the herbal raw material of following parts by weight proportioning:
Radix Notoginseng 3.3-7, Rhizoma Paridis 3.3-7, Rhizoma Cibotii 20-40, Herba Epimedii 30-50, Radix Angelicae Pubescentis 10-20,
Radix Dipsaci 20-40, Herba Taxilli 20-40, Radix Rehmanniae Preparata 30-80, Radix Aucklandiae 8-12, Olibanum 10-20,
Myrrha 10-20, manufacture-yellow Radix Aconiti Kusnezoffii 3.3-13, Radix Scutellariae 6.6-20, Rhizoma Acori Graminei 6.6-13,
Radix dactylicapni (Radix Dactylicapnotis) 0.66-2, Delavay ampelopsis root 3.3-6.6, Pseudostreblus indica Bur. 6.6-20, Radix seu Cortex Heteropanacis 3.3-6.6,
Radix Psammosilenes 2-3.3, Radix Gentianae Macrophyllae 3.3-5.
2. the Chinese medicine composition of treatment acute ankle sprain according to claim 1 is characterized in that: the Chinese medicine composition of this treatment acute ankle sprain is to be made by the herbal raw material of following parts by weight proportioning:
Radix Notoginseng 5-6, Rhizoma Paridis 5-6, Rhizoma Cibotii 30-35, Herba Epimedii 40-45, Radix Angelicae Pubescentis 15-18,
Radix Dipsaci 30-35, Herba Taxilli 30-35, Radix Rehmanniae Preparata 50-60, Radix Aucklandiae 9-10, Olibanum 15-18,
Myrrha 15-18, manufacture-yellow Radix Aconiti Kusnezoffii 8-10, Radix Scutellariae 10-15, Rhizoma Acori Graminei 8-10,
Radix dactylicapni (Radix Dactylicapnotis) 1-1.5, Delavay ampelopsis root 4.5-5.5, Pseudostreblus indica Bur. 10-15, Radix seu Cortex Heteropanacis 4.5-5.5,
Radix Psammosilenes 2.5-3, Radix Gentianae Macrophyllae 4-4.5.
3. the Chinese medicine composition of treatment acute ankle sprain according to claim 1 and 2 is characterized in that: the Chinese medicine composition of this treatment acute ankle sprain is to be made by the herbal raw material of following parts by weight proportioning:
Radix Notoginseng 5, Rhizoma Paridis 5, Rhizoma Cibotii 30, Herba Epimedii 40, Radix Angelicae Pubescentis 15,
Radix Dipsaci 30, Herba Taxilli 30, Radix Rehmanniae Preparata 55, the Radix Aucklandiae 10, Olibanum 15,
Myrrha 15, manufacture-yellow Radix Aconiti Kusnezoffii 8, Radix Scutellariae 15, Rhizoma Acori Graminei 10, Radix dactylicapni (Radix Dactylicapnotis) 1.5,
Delavay ampelopsis root 5, Pseudostreblus indica Bur. 15, Radix seu Cortex Heteropanacis 5, Radix Psammosilenes 2.6, Radix Gentianae Macrophyllae 4.
4. the Chinese medicine composition of treatment acute ankle sprain according to claim 1 and 2 is characterized in that: the dosage form of the Chinese medicine composition of this treatment acute ankle sprain is capsule, tablet, pill, granule or oral liquid.
5. the Chinese medicine composition of treatment acute ankle sprain according to claim 3 is characterized in that: the dosage form of the Chinese medicine composition of this treatment acute ankle sprain is capsule, tablet, pill, granule or oral liquid.
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| CN101279017A (en) * | 2008-05-22 | 2008-10-08 | 云南植物药业有限公司 | Yunnan hongyao extract and extracting method thereof and application |
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| CN101279017A (en) * | 2008-05-22 | 2008-10-08 | 云南植物药业有限公司 | Yunnan hongyao extract and extracting method thereof and application |
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