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CN101391130A - External wireless nerve stimulation device - Google Patents

External wireless nerve stimulation device Download PDF

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Publication number
CN101391130A
CN101391130A CNA2008102016210A CN200810201621A CN101391130A CN 101391130 A CN101391130 A CN 101391130A CN A2008102016210 A CNA2008102016210 A CN A2008102016210A CN 200810201621 A CN200810201621 A CN 200810201621A CN 101391130 A CN101391130 A CN 101391130A
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module
control
electrode
micro
stimulus
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任秋实
柴新禹
吴开杰
牛帅
王洪良
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Shanghai Jiaotong University
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Shanghai Jiaotong University
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Abstract

Disclosed is an external wireless nerve stimulation device belonging to the medical apparatus technique field, which comprises a control console part, a micro-current stimulator part and a stimulating electrode part. The control console part completes the input of stimulation parameters, encodes and modulates the stimulation parameters, and transmits the parameters to the micro-current stimulator part wirelessly; and the micro-current stimulator part decodes the received information, selects stimulation generating channels according to the stimulation parameters, and generates stimulation waveforms. The stimulating electrode part is planted into an animal body. The stimulation waveforms are determined by the stimulation parameters exclusively, and the stimulation channels are also determined by the stimulation parameters. The wireless transmission scheme and the modular power supply can realize the real-time control to stimulation electrical pulses, and also enhance the applicability and security of the stimulation device, and the invention has advantages of small size, low power consumption and powerful functions.

Description

External wireless nerve stimulation device
Technical field
The present invention relates to the device in a kind of medical equipment technical field, be specifically related to a kind of external wireless nerve stimulation device.
Background technology
Nervous system disease or damage may have a strong impact on the motion or the sensory function of human body.High speed development along with technology such as neuroscience, computer science, signal processing, realize brain and computer or other devices communicatings and control, allow serious paralytic control external equipment with thinking or consciousness, the blind person utilizes the artificial vision to see light again, and becomes a reality just gradually.And the system that finishes this function be called neural interface (Neuralinterface, NI).Neural interface realizes that by nerve prosthesis motor control and sensory function repair, and the therapeutic effect of research nerve stimulation makes external electronic device and nervous system set up information and is connected.A neural interface system mainly comprises: the signal generator branch, stimulator and electrode part are carried out the information transmission by wired or wireless mode.At first, by external signal generator branch, control information is encoded into the signal of telecommunication as required, is sent to the stimulator drive electrode, produce electric pulse stimulation nerve or muscular tissue.Nerve stimulation device is the important component part of neural interface, not only can be used for carrying out effectively functional rehabilitation, symptom that can also the alleviating neuropathic disease, as: parkinson disease (PD), intractable depression and intractable pain etc.Along with developing rapidly of nerve stimulation device, the treatment of functional neurosurgery as parkinson disease, intractable depression, intractable pain and other the special property sent out dyskinesia, more and more tends to adopt the Minimally Invasive Surgery of nerve stimulation mode.The research in domestic neural interface field mostly is to link to each other with control unit by the stimulator of loaded down with trivial details lead with the neural interface system, to realize the real-time adjusting to stimulus waveform.This wired connection mode has hindered the degree of freedom of animal behavior, makes result of study can not truly reflect the effect of nerve stimulation.
Find that through literature search State Patent Office's disclosed patent CN 101185789A " implantation type nerve micro-stimulus and gathering remote-controlled chip " has stated a kind of distance type nerve micro-stimulus device to prior art.Because this patent is that the nerve micro-stimulus chip is implanted in the brain of animal, and specialized designs energy coupling power module, to reach to the purpose of implanting the chip energy supply.Yet in actual application, adopt contactless energy coupled transfer scheme, energy transmission efficiency very low (" Analysis of Class-E Amplifier with MixedData Modulation for Biotelemetry, " in Proc.IEEE 29th EMBS Ann.InternConf., Aug 2007, pp.5679-5682., point out in one literary composition that after PSK, OOK, FSK carrier modulation, the energy transmission efficiency simulation result has only 25.9% respectively, 32.7%, 29%.And primary and secondary coil is subject to the air gap size, transmission frequency, relative position influence, efficient less than 10% in side circuit).Contactless energy coupled transfer scheme electric energy transmitting efficient is low, and power consumption is big, has a strong impact on implanting the driving force of chip.In addition, consider individual variation, different syndromes and stimulate the sensitive level difference, stimulus waveform requires to obtain in real time, continuous control, and this patent does not propose stimulus waveform control method accurately, can not guarantee to import charge balance in the body, the electric current of generation easily causes the animal nerve damage.Defective causes this patent can not obtain practical application in sum.
Summary of the invention
The present invention is directed to above shortcomings in the prior art, a kind of external wireless nerve stimulation device is provided, make it on the basis of above-mentioned prior art, adopt real-time stimulus waveform control and wireless telecommunications and modular power supply that scheme is provided, be applicable to the neural stimulation system of various neural interfaces more.
The present invention is achieved by the following technical solutions, the present invention includes control station part, micro-current stimulator part and stimulating electrode part.Control station part and micro-current stimulator partly place in the body, and stimulating electrode places in the body.The micro-current stimulator part partly links to each other with control station by wireless radio frequency mode, partly links to each other with the stimulating electrode that implants by wired mode.Wherein:
Control station is partly finished the stimulus parameter input, and stimulus parameter is encoded, modulated, and adopts wireless mode to send to the micro-current stimulator part;
The micro-current stimulator part selects to stimulate the generation passage with the information decoding that receives according to stimulus parameter, produces stimulus waveform;
Stimulating electrode is partly implanted in the animal body, and stimulus waveform is by the unique decision of stimulus parameter, and stimulation channels is also by the unique decision of stimulus parameter.
Described control station part comprises PC, USB communication module, USB supply module and radio frequency transmitting element.The radio frequency transmitting element comprises transmission control module and sending module.The input of the output termination USB communication module of PC, the outfan of USB communication module are connected to the input that sends control module in the radio frequency transmitting element, and the outfan that sends control module is connected to the input of sending module.Concrete stimulus parameter by the PC input, through the USB communication module, stimulus parameter is transported to the transmission control module of radio frequency transmitting element from the USB communication module by the UART oral instructions,, the control command word is outputed to sending module by the SPI mouth through sending control module coding back generation control command word.Sending module is finished command word radio frequency sending function.The USB supply module of control station part is finished correlation and is taken place frequently and send the power supply that sends control module and sending module in the unit, and the USB mouth voltage of PC is directly offered the radio frequency transmitting element behind step-down rectifier.The high-voltage noise of moment owing in the signal transduction process of USB, can mix, these noises will produce fatal harm to the transmission circuit of USB mouth, therefore the USB communication module comprises that filter circuit suppresses these noise voltages, to guarantee the safety of hardware device.
Described micro-current stimulator part comprises rf receiver unit, electrode drive module and power management module.Rf receiver unit comprises receiver module and receives control module.The outfan of receiver module connects the input that receives control module, receives the outfan connection electrode driver module of control module.The outfan of power management module is connected to receiver module, receives control module and electrode drive module.The sending module of radio frequency transmitting element with the control command word after wireless mode sends, the receiver module of rf receiver unit receives and by the SPI mouth reception control module is delivered in the control command word, after receiving the control module decoding, receive control module according to stimulus parameter control electrode driver module, select to stimulate passage takes place, produce stimulus waveform.The electrode drive module adopts the integrated multichannel of ASIC technology, and volume is little, and has isolation features, stimulating electrode and power supply, control circuit and stimulus waveform signal is isolated fully, to guarantee the safety of tested biology.The power management module of micro-current stimulator part adopts lithium ion battery, finishes the power supply of receiver module, reception control module and electrode drive module to rf receiver unit.
Described stimulating electrode part comprises strand and stimulating electrode.Stimulating electrode links to each other by the electrode drive module of strand with the micro-current stimulator part.Stimulating electrode requires and can be implanted in the animal body safely.
Wireless communication mode, the experiment inconvenience of avoiding loaded down with trivial details lead to bring are adopted in the control of stimulus waveform of the present invention; Use the radio band of 2.4GHz, this frequency range belongs to industry, science and medical treatment (ISM) frequency range of the permission that need not to apply for; The electrode drive module adopts the integrated multichannel of ASIC technology, helps the microminiaturization of device, and is powerful; The micro-current stimulator part is external, adopt the modularity power supply mode, practicality increases greatly, is applicable to the neural stimulation system of various neural interfaces.System of the present invention realizes simply, and complete function helps the process of emulation nerve electric stimulation, also can finish animal and clinical experiment.
Description of drawings
Fig. 1 is a system structure sketch map of the present invention
Fig. 2 is stimulus parameter decision waveform sketch map of the present invention
Fig. 3 is an electrode drive module interface sketch map of the present invention
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated: present embodiment is being to implement under the prerequisite with the technical solution of the present invention, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
As shown in Figure 1, present embodiment comprises control station part, micro-current stimulator part and stimulating electrode part.Control station part and micro-current stimulator partly place in the body, and stimulating electrode places in the body.The micro-current stimulator part partly links to each other with control station by wireless radio frequency mode, partly links to each other with the stimulating electrode that implants by wired mode.
Control station is partly finished the stimulus parameter input, and stimulus parameter is encoded, modulated, and adopts wireless mode to send to the micro-current stimulator part; The micro-current stimulator part selects to stimulate the generation passage with the information decoding that receives according to stimulus parameter, produces stimulus waveform.Stimulating electrode is partly implanted in the animal body.Stimulus waveform is by the unique decision of stimulus parameter, and stimulation channels is also by the unique decision of stimulus parameter.
Stimulus parameter determines the waveform sketch map as shown in Figure 2, and major function is for partly selecting stimulation channels and waveform by stimulus parameter control micro-current stimulator is set.Stimulation channels is selected and waveform needs 9 parameter decisions.Can determine unique waveform from No.1 to the No.8 parameter, wave amplitude, frequency, persistent period and time delay are all adjustable continuously.The No.9 parameter is set channel electrode.
The explanation of table 1. stimulus parameter
Figure A200810201621D00071
Control station part block diagram comprises PC, USB communication module, USB supply module and radio frequency transmitting element as shown in Figure 1.The radio frequency transmitting element comprises transmission control module and sending module.The input of the output termination USB communication module of PC, the outfan of USB communication module are connected to the input that sends control module, and the outfan that sends control module connects the input of sending module.Concrete stimulus parameter by the PC input, through the USB communication module, stimulus parameter is transported to the transmission control module from the USB communication module by the UART oral instructions, after sending the control module coding, produce the control command word, the control command word is outputed to sending module by the SPI mouth.Sending module is finished command word radio frequency sending function.The USB supply module of control station part is finished correlation and is taken place frequently and send the power supply of unitary transmission control module and sending module, and the USB mouth voltage of PC is directly offered the radio frequency transmitting element behind step-down rectifier.The high-voltage noise of moment owing in the signal transduction process of USB, can mix, these noises will produce fatal harm to the transmission circuit of USB mouth, therefore the USB communication module comprises that filter circuit suppresses these noise voltages, to guarantee the safety of hardware device.Select in the middle of the present invention that power consumption is lower, the little MCU of encapsulation and radio-frequency transmissions chip, further saved electric energy.
The control station part adopts the ZigBee technology with the wireless telecommunications of wireless nerve stimulation device part.ZigBee (IEEE 802.15.4) is the wireless connect technology of a kind of low complex degree well known already, cost and power consumption, can be embedded in various fixing, the portable or portable control appliances.The ZigBee node can be operated in 3 kinds of different frequency ranges (915MHz, 838MHz and 2.4GHz).Among the present invention, stimulus waveform control word packet only contains 8 waveform parameters and 1 channel selecting parameter, and the above traffic rate of byte each seconds tens can meet the demands.Therefore the 2.4GHz ISM band is adopted in the radio-frequency communication transceiver part, and 16 channels are arranged, and basic propagation rate is 250Kbps.Compare with wireless communication technique such as bluetooth, the response speed of ZigBee is very fast, and generally changing duty over to from sleep only needs the 15ms. node to connect to enter network only to need 30ms, helps the real-time control of control station to stimulus waveform.
Micro-current stimulator part sketch map comprises rf receiver unit shown in Fig. 1,3, electrode drive module and power management module.Rf receiver unit comprises receiver module and receives control module.The outfan of receiver module is connected to the input that receives control module in the rf receiver unit, receives the outfan connection electrode driver module of control module.The output termination receiver module of power management module, reception control module and electrode drive module.The control command word of sending module is after wireless mode sends in the radio frequency transmitting element, receiver module receives and by the SPI mouth reception control module is delivered in the control command word in the rf receiver unit, after receiving the control module decoding, receiving control module drives according to the stimulus parameter control electrode, select to stimulate passage takes place, produce stimulus waveform.The electrode drive module adopts the integrated multichannel of ASIC technology, and volume is little, and has isolation features, and with stimulating electrode and power supply, control circuit and stimulus waveform signal are isolated fully, to guarantee the safety of tested biology.The power management module of micro-current stimulator part adopts lithium ion battery, finishes the power supply of receiver module, reception control module and electrode drive module to rf receiver unit.Based on the electrode drive of ASIC technology, to utilize the two-way microelectric current of 16 passages of high impedance driving, volume is 3cm * 2cm * 0.3cm.The power supply of 3V rechargeable lithium ion batteries is adopted in the power supply of micro-current stimulator part.Lithium ion battery is in light weight, volume is little, energy density is high, can guarantee to continue to stimulate about 24hour.The electrode drive module interface of ASIC design adopts 12 pins, comprises Vdd, Vss and 10 control lines.
Table 2 electrode drive module interface and reception control module interface connecting method
Receive the control module interface The electrode drive module interface Function declaration
No.1 Addr0 Channel address selects 0
No.2 Addr1 Channel address selects 1
No.3 Addr2 Channel address selects 2
No.4 Addr3 Channel address selects 3
No.5 Polarity Pulse polarity is selected, positive pulse during high level
No.6 Gain0 The pulse gain selects 0
No.7 Gain1 The pulse gain selects 1
No.8 Gain2 The pulse gain selects 2
No.9 SysCLK System clock
No.10 ActiAdd Passage enables to select, and passage enables during high level
VDD Vdd Power line
GND Vss Ground wire
In last table, the electrode drive module is connected with the corresponding pin that receives control module.Addr0, Addr1, four address wires of Addr2, Addr2 can be selected 16 passages; Polarity is that high level is, the output direct impulse, and when Polarity is low level, the output negative-going pulse.Gain0, Gain1, Gain2 can be that the amplitude of stimulus waveform is adjustable at 8 orders of magnitude.By software programming, the present invention can realize the control of the stimulus waveform of 16 passages, comprises waveform, frequency, pulsewidth and the amplitude of boost pulse, realizes regulating continuously on a large scale.
Micro-current stimulator part sketch map comprises strand and stimulating electrode as shown in Figure 1.Stimulating electrode links to each other by the electrode drive module of strand with the micro-current stimulator part.Stimulating electrode requires and can be implanted in the animal body safely.

Claims (7)

1. external wireless nerve stimulation device, it is characterized in that comprising control station part, micro-current stimulator part and stimulating electrode part, control station part and micro-current stimulator partly place in the body, stimulating electrode places in the body, the micro-current stimulator part partly links to each other with control station by wireless radio frequency mode, partly link to each other with the stimulating electrode that implants by wired mode, wherein:
Control station is partly finished the stimulus parameter input, and stimulus parameter is encoded, modulated, and adopts wireless mode to send to the micro-current stimulator part;
The micro-current stimulator part selects to stimulate the generation passage with the information decoding that receives according to stimulus parameter, produces stimulus waveform;
Stimulating electrode is partly implanted in the animal body, and stimulus waveform is by the unique decision of stimulus parameter, and stimulation channels is also by the unique decision of stimulus parameter.
2. external wireless nerve stimulation device according to claim 1, it is characterized in that, described control station part, comprise PC, the USB communication module, USB supply module and radio frequency transmitting element, the radio frequency transmitting element comprises transmission control module and sending module, wherein: the input of the output termination USB communication module of PC, the outfan of USB communication module is connected to the input that sends control module in the radio frequency transmitting element, the outfan that sends control module is connected to the input of sending module, concrete stimulus parameter by the PC input, through the USB communication module, stimulus parameter is transported to the transmission control module of radio frequency transmitting element by the UART oral instructions from the USB communication module, after sending the control module coding, produce the control command word, by the SPI mouth control command word is outputed to sending module, sending module is finished command word radio frequency sending function, the USB supply module of control station part is finished correlation and is taken place frequently and send the power supply that sends control module and sending module in the unit, and the USB mouth voltage of PC is directly offered the radio frequency transmitting element behind step-down rectifier.
3. external wireless nerve stimulation device according to claim 2 is characterized in that, described USB communication module comprises filter circuit, and the instantaneous pressure noise that advances that mixes in the signal transduction process of USB is suppressed.
4. external wireless nerve stimulation device according to claim 1, it is characterized in that, described micro-current stimulator part, comprise rf receiver unit, electrode drive module and power management module, rf receiver unit comprises receiver module and receives control module, wherein: the outfan of receiver module is connected to the input that receives control module in the rf receiver unit, receive the outfan connection electrode driver module of control module, the output termination receiver module of power management module, receive control module and electrode drive module, the control command word of sending module is after wireless mode sends in the radio frequency transmitting element, receiver module receives and by the SPI mouth reception control module is delivered in the control command word in the rf receiver unit, after receiving the control module decoding, receiving control module drives according to the stimulus parameter control electrode, select to stimulate the generation passage, produce stimulus waveform, the electrode drive module is with stimulating electrode and power supply, control circuit and stimulus waveform signal are isolated fully, power management module adopts lithium ion battery, finishes the receiver module to rf receiver unit, receive the power supply of control module and electrode drive module.
5. according to claim 1 or 4 described external wireless nerve stimulation devices, it is characterized in that, described micro-current stimulator part is controlled it by stimulus parameter and is selected stimulation channels and waveform, stimulation channels is selected and waveform needs 9 parameter decisions, 9 parameters are respectively circulation number Cyc Num, initial delay time StaTime, pulse begins Neg First, positive pulse gain Pos Gain, positive pulse duration Pos Time, negative pulse gain, negative pulse duration Neg Time, Off Time time delay behind each end cycle of pulse, set the pairing electrode Prob of each passage Ch, wherein parameter Prob Ch sets channel electrode, other 8 parameters can be determined unique waveform, realize the stimulus waveform amplitude, frequency, blanking time is adjustable.
6. external wireless nerve stimulation device according to claim 4 is characterized in that, described electrode drive module adopts the integrated multichannel of ASIC technology.
7. external wireless nerve stimulation device according to claim 1, it is characterized in that described stimulating electrode part comprises strand and stimulating electrode, stimulating electrode links to each other with the electrode drive module by strand, and stimulating electrode can be implanted in the animal body safely.
CNA2008102016210A 2008-10-23 2008-10-23 External wireless nerve stimulation device Pending CN101391130A (en)

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101797420A (en) * 2010-01-06 2010-08-11 杜廷海 Remote control therapeutic instrument
CN102698360A (en) * 2012-04-21 2012-10-03 南京理工大学 High-focusing-capability multi-channel transcranial direct current stimulation device and control method thereof
CN102872533A (en) * 2012-09-11 2013-01-16 上海市东方医院 Muscle restoration system for paralyzed limbs
CN104874102A (en) * 2015-04-02 2015-09-02 中国科学院苏州生物医学工程技术研究所 Multi-channel wireless closed loop deep brain neural sensing and control system
CN105530991A (en) * 2013-09-11 2016-04-27 美敦力公司 Implantable medical devices with power supply noise isolation
CN105879222A (en) * 2016-04-01 2016-08-24 上海交通大学 Electrical stimulation system for small animal motion control and using method thereof
CN107073266A (en) * 2014-09-23 2017-08-18 波士顿科学神经调制公司 The system and method for the selection that user for receiving electrode list provides
CN107137817A (en) * 2017-06-21 2017-09-08 无锡佳健医疗器械股份有限公司 Wireless low-frequency electronic pulse therapeutic equipment
CN108159564A (en) * 2013-01-28 2018-06-15 重塑生命科学股份有限公司 System for applying therapy to a target nerve of a patient
CN110801223A (en) * 2019-09-30 2020-02-18 昆明理工大学 Wireless brain deep nerve interface system
CN114588544A (en) * 2020-12-04 2022-06-07 林珊如 Electromagnetic device matched with frequency micro-current device for operation and application method thereof
CN116916455A (en) * 2023-06-06 2023-10-20 北京领创医谷科技发展有限责任公司 Channel selection method, system and equipment of nerve stimulation system

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101797420A (en) * 2010-01-06 2010-08-11 杜廷海 Remote control therapeutic instrument
CN102698360A (en) * 2012-04-21 2012-10-03 南京理工大学 High-focusing-capability multi-channel transcranial direct current stimulation device and control method thereof
CN102872533A (en) * 2012-09-11 2013-01-16 上海市东方医院 Muscle restoration system for paralyzed limbs
CN102872533B (en) * 2012-09-11 2015-08-05 上海市东方医院 Paralyzed limbs muscle reactivation system
CN108159564A (en) * 2013-01-28 2018-06-15 重塑生命科学股份有限公司 System for applying therapy to a target nerve of a patient
CN105530991B (en) * 2013-09-11 2017-11-17 美敦力公司 Implantable medical device with power supply noise isolation
CN105530991A (en) * 2013-09-11 2016-04-27 美敦力公司 Implantable medical devices with power supply noise isolation
CN107073266B (en) * 2014-09-23 2020-08-11 波士顿科学神经调制公司 System and method for receiving user-provided selections of electrode lists
CN107073266A (en) * 2014-09-23 2017-08-18 波士顿科学神经调制公司 The system and method for the selection that user for receiving electrode list provides
CN104874102A (en) * 2015-04-02 2015-09-02 中国科学院苏州生物医学工程技术研究所 Multi-channel wireless closed loop deep brain neural sensing and control system
CN105879222A (en) * 2016-04-01 2016-08-24 上海交通大学 Electrical stimulation system for small animal motion control and using method thereof
CN107137817A (en) * 2017-06-21 2017-09-08 无锡佳健医疗器械股份有限公司 Wireless low-frequency electronic pulse therapeutic equipment
CN110801223A (en) * 2019-09-30 2020-02-18 昆明理工大学 Wireless brain deep nerve interface system
CN114588544A (en) * 2020-12-04 2022-06-07 林珊如 Electromagnetic device matched with frequency micro-current device for operation and application method thereof
CN116916455A (en) * 2023-06-06 2023-10-20 北京领创医谷科技发展有限责任公司 Channel selection method, system and equipment of nerve stimulation system
CN116916455B (en) * 2023-06-06 2024-06-11 北京领创医谷科技发展有限责任公司 Channel selection method, system and equipment of nerve stimulation system

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