CN101259102A - Micrometre level docosahexaenoic acid emulsion and preparation thereof - Google Patents
Micrometre level docosahexaenoic acid emulsion and preparation thereof Download PDFInfo
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Abstract
The invention discloses an emulsion of micron-sized docosahexenoic acid (DHA) and a preparation method thereof. The emulsion of micron-sized docosahexenoic acid (DHA) comprises: 50g to 150g of DHA, 10g to 50g of coating agent, 14g to 130g of oil phase emulsifier, 8g to 50g of aqueous phase emulsifier, 75g to 350g of thickening and stabilizing agent, 10g to 100g of dispersant and 0.5g to 20g of antioxidant; water is added for obtaining solution of 1000g. The emulsion of the invention is O/W type and mainly characterized in that the emulsifiers and the thickening and stabilizing agent are emulsified with the DHA and water according to certain proportions so as to obtain the emulsion with stable status and emulsified particle diameter less than 1 micron. The invention provides a prescription of a DHA emulsion capable of dispersing in cold water, provided with good stability and is stable against light, heat and oxygen and can be conveniently used in beverage, food and other relevant industries.
Description
Technical field
The present invention relates to a kind of micrometre level docosahexaenoic acid emulsion and preparation method thereof, particularly need a kind of docosahexenoic acid emulsion and technology and the application used in food, medicine, health product, the cosmetic industry.The present invention uses as nutrition enhancer.
Technical background
Docosahexenoic acid is the serial long-chain polyunsaturated fatty acid of ω-3 (PUFA).DHA is the polyunsaturated fatty acid of needed by human, it is a fatty acid composition important in brain, nerve and the optic cell, the normal performance of human body physiological function and the control of multiple disease there are important function, particularly in infant brain and development of vision system process, occupy crucial status.DHA mainly is present in the grey matter part in brain, be lipid components main in the human brain neuron membrane, also is the fatty acid composition that the brain cell preferential absorption is utilized.DHA is an important nutritional labeling in the infant neurocyte growth course, with the degree of being quick on the draw in its developmental process much relations is arranged.If lack DHA in the diet, can cause the child, especially the learning capacity of infant descends, and suffers from nervous system disease simultaneously, and is also higher as neurosal probability.The women if lack DHA in the diet, also can influence fetal brain and neural normal development at phenolics, and its posteriori IQ index.
The content of DHA in optic cell and retinal tissue, can make DHA content decline in the retinal tissue, thereby cause visual deterioration if lack DHA in the food up to 25%.U.S.'s " clinical nutriology magazine " report, the baby who replenishes DHA in the food is on the feed after 3 weeks, and vision is obviously than the healthy babies sensitivity of the DHA that do not take food on the same group.The concentration of DHA is on the low side in premature infant's body, needs to replenish especially DHA, just can make the interior DHA concentration of its body go back up to normal level.
Patent CN1890376A, patent CN1358839A, patent CN1101034A and patent CN1986822A disclose the greasy preparation method of its microalgae DHA, and the greasy concrete application approach of DHA are not explained in detail explanation.
The DHA oils and fats is exposed to very easily oxidation in the air, can not withstand high temperatures, thereby be difficult under its active condition of effective maintenance and directly be used in the infant formula food.Patent CN1731983A and patent CN1927050A disclose the active method of a kind of effective maintenance DHA, promptly be the DHA oils and fats to be re-used as nutrition enhancer add in the food behind micro encapsulation, though this has comparatively effectively solved the defective of its easy oxidation inactivation, kept its activity in use, but also existing to add uses technology loaded down with trivial details, the defective that is difficult to mix homogeneously, and energy consumption is high in the process of DHA grease microcapsuleization, has increased production cost greatly.
Therefore, promote the use of in the process, all required a kind of production economically feasible always, use the simple and easy greasy end product of DHA at DHA.
Summary of the invention
The purpose of this invention is to provide a kind of technology simple possible, DHA absorption rate height, during use in water docosahexenoic acid emulsion of stable performance such as good dispersion property, fast light, oxytolerant, acid and alkali-resistance and preparation method thereof.
Technical scheme of the present invention: micrometre level docosahexaenoic acid emulsion of the present invention comprises:
(H) docosahexenoic acid 50g～150g;
(I) fruit glaze agent 10g-50g;
(J) oil phase emulsifier 14g-130g;
(K) aqueous emulsifier phase 8g-50g;
(L) thickening stabilizing agent 75g-350g;
(M) dispersant 10g-100g;
(N) antioxidant 0.5g-20g;
(H) add water to 1000g.
Described emulsion, oil phase emulsifier are a kind of in soybean lecithin, sorbester p18, sorbester p17, sorbester p37, monoglyceride, polyglycerin ester, the sodium stearoyl lactate, or two kinds and two or more; Aqueous emulsifier phase is a kind of in citric acid fatty glyceride, polysorbate40, polysorbate60, Tween 80, sucrose fatty acid ester, diacetyl tartarate fatty glyceride, the sodium caseinate, or two kinds and two or more.
Described emulsion, its thickening stabilizing agent are a kind of in modified starch, xanthan gum, pectin, agar, beta-schardinger dextrin-, sodium alginate, gelatin, chitosan, the modified cellulose, or two kinds and two or more.
Described emulsion, its fruit glaze agent are a kind of in Oleum Arachidis hypogaeae semen, Oleum Cocois, Oleum Helianthi, Petiolus Trachycarpi oil, the soybean oil, also can be two or more.
Described emulsion, its antioxidant are a kind of in natural VE, ascorbyl palmitate, sodium ascorbate, tertiarybutylhydroquinone, tea polyphenols, the Herba Rosmarini Officinalis, or two kinds and two or more.
The preparation method of docosahexenoic acid emulsion of the present invention, step is:
1) oil phase part: after by above-mentioned weight ratio concentration being higher than 30% docosahexaenoic acid grease and adding oil phase emulsifier, fruit glaze agent, antioxidant, oil bath is heated to 40～70 ℃, makes it dissolving, makes the oil phase product A;
2) aqueous portion: by above-mentioned weight ratio aqueous emulsifier phase, stabilizing agent, dispersant are added in the entry, fully stir, be heated to 60～90 ℃, keep 20～60min, make the water product B;
3) treat that water product B temperature reduces to 40～70 ℃, A is slowly joined among the B, carry out emulsifying just, obtain products C with high-speed shearing machine;
4) products C is carried out the pressure homogenizing, obtain product D;
5) with obtaining product E after product D sterilization, the cooling, be docosahexenoic acid emulsion.
The preparation method of described emulsion, process for sterilizing wherein adopts pasteurize, ultra high temperature short time sterilization, and adds the antistaling agent anti-rot and fresh-keeping method.
It is 2000～10000 rev/mins that the preparation method of described emulsion, high-speed shearing machine are carried out first emulsifying rotating speed, and the time is 10～60 minutes.
The preparation method of described emulsion wherein needs twice pressure homogenizing at least, and wherein at least homogenization pressure is more than 200MPa.
The purposes of micrometre level docosahexaenoic acid emulsion of the present invention, micrometre level docosahexaenoic acid emulsion is used for medicine, cosmetics, health product and food, directly add, or use with common interpolation of other batchings, addition accounts for 0.05～2.5% of gross weight
Advantage of the present invention: docosahexenoic acid emulsion of the present invention is an emulsion stable on the thermodynamics, according to using needs can make the emulsion that different-grain diameter distributes, particle size range 0.1-1 micron.Can in medicine, health product and food, directly add, also can use, with the docosahexenoic acid content of fortification system with common interpolation of other batchings.Offering in food such as liquid milk, fruit drink, fruit jelly, ice cream etc. needs the crowd who replenishes docosahexenoic acid to use.The crowd includes but not limited to infant, child, teenager, anemia of pregnant woman or women breast-feeding their children.Described docosahexenoic acid emulsion directly interpolation is meant in view of homodisperse performance in the good water of emulsion, can directly add with main mixing of materials in batching, and need not special uniform mixing course of dissolution.
The specific embodiment
Micrometre level docosahexaenoic acid emulsion of the present invention comprises:
(O) docosahexenoic acid 50g～150g;
(P) fruit glaze agent 10g-50g;
(Q) oil phase emulsifier 14g-130g;
(R) aqueous emulsifier phase 8g-50g;
(S) thickening stabilizing agent 75g-350g;
(T) dispersant 10g-100g;
(U) antioxidant 0.5g-20g;
(H) add water to 1000g.
Described emulsion, oil phase emulsifier are a kind of in soybean lecithin, sorbester p18, sorbester p17, sorbester p37, monoglyceride, polyglycerin ester, the sodium stearoyl lactate, or two kinds and two or more; Aqueous emulsifier phase is a kind of in citric acid fatty glyceride, polysorbate40, polysorbate60, Tween 80, sucrose fatty acid ester, diacetyl tartarate fatty glyceride, the sodium caseinate, or two kinds and two or more.
Described emulsion, its thickening stabilizing agent are a kind of in modified starch, xanthan gum, pectin, agar, beta-schardinger dextrin-, sodium alginate, gelatin, chitosan, the modified cellulose, or two kinds and two or more.
Described emulsion, its fruit glaze agent are a kind of in Oleum Arachidis hypogaeae semen, Oleum Cocois, Oleum Helianthi, Petiolus Trachycarpi oil, the soybean oil, also can be two or more.
Described emulsion, its antioxidant are a kind of in natural VE, ascorbyl palmitate, sodium ascorbate, tertiarybutylhydroquinone, tea polyphenols, the Herba Rosmarini Officinalis, or two kinds and two or more.
The preparation method of docosahexenoic acid emulsion of the present invention, step is:
1) oil phase part: after by above-mentioned weight ratio concentration being higher than 30% docosahexaenoic acid grease and adding oil phase emulsifier, fruit glaze agent, antioxidant, oil bath is heated to 40～70 ℃, makes it dissolving, makes the oil phase product A;
2) aqueous portion: by above-mentioned weight ratio aqueous emulsifier phase, stabilizing agent, dispersant are added in the entry, fully stir, be heated to 60～90 ℃, keep 20～60min, make the water product B;
3) treat that water product B temperature reduces to 40～70 ℃, A is slowly joined among the B, carry out emulsifying just, obtain products C with high-speed shearing machine;
4) products C is carried out the pressure homogenizing, obtain product D;
5) with obtaining product E after product D sterilization, the cooling, be docosahexenoic acid emulsion.
The preparation method of described emulsion, process for sterilizing wherein adopts pasteurize, ultra high temperature short time sterilization, and adds the antistaling agent anti-rot and fresh-keeping method.
It is 2000～10000 rev/mins that the preparation method of described emulsion, high-speed shearing machine are carried out first emulsifying rotating speed, and the time is 10～60 minutes.
The preparation method of described emulsion wherein needs twice pressure homogenizing at least, and wherein at least homogenization pressure is more than 200MPa.
The purposes of micrometre level docosahexaenoic acid emulsion of the present invention, micrometre level docosahexaenoic acid emulsion is used for medicine, cosmetics, health product and food, directly add, or use with common interpolation of other batchings, addition accounts for 0.05～2.5% docosahexenoic acid (DHA) the emulsion embodiment of gross weight:
Embodiment 1 contains the preparation of DHA50g/kg emulsion:
Take by weighing compound lard 145 grams of 35% docosahexenoic acid content, antioxidant 0.5 gram (comprises natural Vitamin E 0.2 gram, sodium ascorbate 0.1 gram, tea polyphenols 0.2 gram), fruit glaze agent 10 grams (comprise Oleum Helianthi 5 grams, Petiolus Trachycarpi oil 5 grams), oil phase emulsifier 14 grams (comprise lecithin 6 grams, 8 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 8 grams (comprising citric acid fatty glyceride 3 grams, 5 gram polysorbate65s), and dispersant 10 grams (comprising sucrose 10 grams) and thickening stabilizing agent 75 grams (comprise modified starch 70 grams, sodium alginate 5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 2 contains the preparation method of DHA50g/kg emulsion:
Take by weighing compound lard 145 grams of 35% docosahexenoic acid content, antioxidant 10.25 grams (comprise natural Vitamin E 4 grams, sodium ascorbate 2.25 grams, tea polyphenols 4 grams), fruit glaze agent 30 grams (comprise Oleum Helianthi 15 grams, Petiolus Trachycarpi oil 15 grams), oil phase emulsifier 72 grams (comprise lecithin 30 grams, 42 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 29 grams (comprising citric acid fatty glyceride 10.8 grams, 18.2 gram polysorbate65s), and dispersant 55 grams (comprising sucrose 55 grams) and thickening stabilizing agent 212.5 grams (comprise modified starch 195 grams, sodium alginate 17.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 3 contains the preparation method of DHA50g/kg emulsion:
Take by weighing compound lard 145 grams of 35% docosahexenoic acid content, antioxidant 20 grams (comprise natural Vitamin E 8 grams, sodium ascorbate 4 grams, tea polyphenols 8 grams), fruit glaze agent 50 grams (comprise Oleum Helianthi 25 grams, Petiolus Trachycarpi oil 25 grams), oil phase emulsifier 130 grams (comprise lecithin 56 grams, 74 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 50 grams (comprising citric acid fatty glyceride 18.7 grams, 31.3 gram polysorbate65s), and dispersant 100 grams (comprising sucrose 100 grams) and thickening stabilizing agent 350 grams (comprise modified starch 325.5 grams, sodium alginate 24.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 4 contains the preparation method of DHA100g/kg emulsion:
Take by weighing compound lard 286 grams of 35% docosahexenoic acid content, antioxidant 20 grams (comprise natural Vitamin E 8 grams, sodium ascorbate 4 grams, tea polyphenols 8 grams), fruit glaze agent 50 grams (comprise Oleum Helianthi 25 grams, Petiolus Trachycarpi oil 25 grams), oil phase emulsifier 14 grams (comprise lecithin 6 grams, 8 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 8 grams (comprising citric acid fatty glyceride 3 grams, 5 gram polysorbate65s), and dispersant 55 grams (comprising sucrose 55 grams) and thickening stabilizing agent 212.5 grams (comprise modified starch 195 grams, sodium alginate 17.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 5 contains the preparation method of DHA100g/kg emulsion:
Take by weighing compound lard 286 grams of 35% docosahexenoic acid content, antioxidant 0.5 gram (comprises natural Vitamin E 0.2 gram, sodium ascorbate 0.1 gram, tea polyphenols 0.2 gram), fruit glaze agent 10 grams (comprise Oleum Helianthi 5 grams, Petiolus Trachycarpi oil 5 grams), oil phase emulsifier 72 grams (comprise lecithin 30 grams, 42 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 29 grams (comprising citric acid fatty glyceride 10.8 grams, 18.2 gram polysorbate65s), and dispersant 100 grams (comprising sucrose 100 grams) and thickening stabilizing agent 350 grams (comprise modified starch 325.5 grams, sodium alginate 24.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 6 contains the preparation method of DHA100g/kg emulsion:
Take by weighing compound lard 286 grams of 35% docosahexenoic acid content, antioxidant 10.25 grams (comprise natural Vitamin E 4 grams, sodium ascorbate 2.25 grams, tea polyphenols 4 grams), fruit glaze agent 30 grams (comprise Oleum Helianthi 15 grams, Petiolus Trachycarpi oil 15 grams), oil phase emulsifier 130 grams (comprise lecithin 56 grams, 74 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 50 grams (comprising citric acid fatty glyceride 18.7 grams, 31.3 gram polysorbate65s), and dispersant 10 grams (comprising sucrose 10 grams) and thickening stabilizing agent 75 grams (comprise modified starch 70 grams, sodium alginate 5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 7 contains the preparation method of DHA150g/kg emulsion:
Take by weighing compound lard 429 grams of 35% docosahexenoic acid content, antioxidant 10.25 grams (comprise natural Vitamin E 4 grams, sodium ascorbate 2.25 grams, tea polyphenols 4 grams), fruit glaze agent 50 grams (comprise Oleum Helianthi 25 grams, Petiolus Trachycarpi oil 25 grams), oil phase emulsifier 14 grams (comprise lecithin 6 grams, 8 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 29 grams (comprising citric acid fatty glyceride 10.8 grams, 5 gram tweens 18.2), and dispersant 100 grams (comprising sucrose 100 grams) and thickening stabilizing agent 75 grams (comprise modified starch 70 grams, sodium alginate 5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 8 contains the preparation method of DHA150g/kg emulsion:
Take by weighing compound lard 429 grams of 35% docosahexenoic acid content, antioxidant 20 grams (comprise natural Vitamin E 8 grams, sodium ascorbate 4 grams, tea polyphenols 8 grams), fruit glaze agent 10 grams (comprise Oleum Helianthi 5 grams, Petiolus Trachycarpi oil 5 grams), oil phase emulsifier 72 grams (comprise lecithin 30 grams, 42 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 50 grams (comprising citric acid fatty glyceride 18.7 grams, 31.3 gram polysorbate65s), and dispersant 10 grams (comprising sucrose 10 grams) and thickening stabilizing agent 212.5 grams (comprise modified starch 195 grams, sodium alginate 17.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 9 contains the preparation method of DHA150g/kg emulsion:
Take by weighing compound lard 429 grams of 35% docosahexenoic acid content, antioxidant 0.5 gram (comprises natural Vitamin E 0.2 gram, sodium ascorbate 0.1 gram, tea polyphenols 0.2 gram), fruit glaze agent 30 grams (comprise Oleum Helianthi 15 grams, Petiolus Trachycarpi oil 15 grams), oil phase emulsifier 130 grams (comprise lecithin 56 grams, 74 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 8 grams (comprising citric acid fatty glyceride 3 grams, 5 gram polysorbate65s), and dispersant 55 grams (comprising sucrose 55 grams) and thickening stabilizing agent 350 grams (comprise modified starch 325.5 grams, sodium alginate 24.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 10 contains the preparation method of DHA50g/kg emulsion:
Take by weighing compound lard 145 grams of 35% docosahexenoic acid content, antioxidant 10.25 grams (comprise natural Vitamin E 4 grams, sodium ascorbate 2.25 grams, tea polyphenols 4 grams), fruit glaze agent 10 grams (comprise Oleum Helianthi 5 grams, Petiolus Trachycarpi oil 5 grams), oil phase emulsifier 14 grams (comprise lecithin 6 grams, 8 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 50 grams (comprising citric acid fatty glyceride 18.7 grams, 31.3 gram polysorbate65s), and dispersant 55 grams (comprising sucrose 55 grams) and thickening stabilizing agent 350 grams (comprise modified starch 325.5 grams, sodium alginate 24.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 11 contains the preparation method of DHA50g/kg emulsion:
Take by weighing compound lard 145 grams of 35% docosahexenoic acid content, antioxidant 20 grams (comprise natural Vitamin E 8 grams, sodium ascorbate 4 grams, tea polyphenols 8 grams), fruit glaze agent 30 grams (comprise Oleum Helianthi 15 grams, Petiolus Trachycarpi oil 15 grams), oil phase emulsifier 72 grams (comprise lecithin 30 grams, 42 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 8 grams (comprising citric acid fatty glyceride 3 grams, 5 gram polysorbate65s), and dispersant 100 grams (comprising sucrose 100 grams) and thickening stabilizing agent 75 grams (comprise modified starch 70 grams, sodium alginate 5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 12 contains the preparation method of DHA50g/kg emulsion:
Take by weighing compound lard 145 grams of 35% docosahexenoic acid content, antioxidant 0.5 gram (comprises natural Vitamin E 0.2 gram, sodium ascorbate 0.1 gram, tea polyphenols 0.2 gram), fruit glaze agent 50 grams (comprise Oleum Helianthi 25 grams, Petiolus Trachycarpi oil 25 grams), oil phase emulsifier 130 grams (comprise lecithin 56 grams, 74 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 29 grams (comprising citric acid fatty glyceride 10.8 grams, 18.2 gram polysorbate65s), and dispersant 10 grams (comprising sucrose 10 grams) and thickening stabilizing agent 212.5 grams (comprise modified starch 195 grams, sodium alginate 17.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 13 contains the preparation method of DHA100g/kg emulsion:
Take by weighing compound lard 286 grams of 35% docosahexenoic acid content, antioxidant 20 grams (comprise natural Vitamin E 8 grams, sodium ascorbate 4 grams, tea polyphenols 8 grams), fruit glaze agent 30 grams (comprise Oleum Helianthi 15 grams, Petiolus Trachycarpi oil 15 grams), oil phase emulsifier 14 grams (comprise lecithin 6 grams, 8 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 29 grams (comprising citric acid fatty glyceride 10.8 grams, 18.2 gram polysorbate65s), and dispersant 10 grams (comprising sucrose 10 grams) and thickening stabilizing agent 350 grams (comprise modified starch 325.5 grams, sodium alginate 24.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 14 contains the preparation method of DHA100g/kg emulsion:
Take by weighing compound lard 286 grams of 35% docosahexenoic acid content, antioxidant 0.5 gram (comprises natural Vitamin E 0.2 gram, sodium ascorbate 0.1 gram, tea polyphenols 0.2 gram), fruit glaze agent 50 grams (comprise Oleum Helianthi 25 grams, Petiolus Trachycarpi oil 25 grams), oil phase emulsifier 72 grams (comprise lecithin 30 grams, 42 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 50 grams (comprising citric acid fatty glyceride 18.7 grams, 31.3 gram polysorbate65s), and dispersant 55 grams (comprising sucrose 55 grams) and thickening stabilizing agent 75 grams (comprise modified starch 70 grams, sodium alginate 5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 15 contains the preparation method of DHA100g/kg emulsion:
Take by weighing compound lard 145 grams of 35% docosahexenoic acid content, antioxidant 10.25 grams (comprise natural Vitamin E 4 grams, sodium ascorbate 2.25 grams, tea polyphenols 4 grams), fruit glaze agent 10 grams (comprise Oleum Helianthi 5 grams, Petiolus Trachycarpi oil 5 grams), oil phase emulsifier 130 grams (comprise lecithin 56 grams, 74 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 8 grams (comprising citric acid fatty glyceride 3 grams, 5 gram polysorbate65s), and dispersant 100 grams (comprising sucrose 100 grams) and thickening stabilizing agent 212.5 grams (comprise modified starch 195 grams, sodium alginate 17.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 16 contains the preparation method of DHA150g/kg emulsion:
Take by weighing compound lard 429 grams of 35% docosahexenoic acid content, antioxidant 0.5 gram (comprises natural Vitamin E 0.2 gram, sodium ascorbate 0.1 gram, tea polyphenols 0.2 gram), fruit glaze agent 30 grams (comprise Oleum Helianthi 15 grams, Petiolus Trachycarpi oil 15 grams), oil phase emulsifier 14 grams (comprise lecithin 6 grams, 8 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 50 grams (comprising citric acid fatty glyceride 18.7 grams, 31.3 gram polysorbate65s), and dispersant 100 grams (comprising sucrose 100 grams) and thickening stabilizing agent 212.5 grams (comprise modified starch 195 grams, sodium alginate 17.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 17 contains the preparation method of DHA150g/kg emulsion:
Take by weighing compound lard 429 grams of 35% docosahexenoic acid content, antioxidant 10.25 grams (comprise natural Vitamin E 4 grams, sodium ascorbate 2.25 grams, tea polyphenols 4 grams), fruit glaze agent 10 grams (comprise Oleum Helianthi 5 grams, Petiolus Trachycarpi oil 5 grams), oil phase emulsifier 72 grams (comprise lecithin 30 grams, 42 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 8 grams (comprising citric acid fatty glyceride 3 grams, 5 gram polysorbate65s), and dispersant 10 grams (comprising sucrose 10 grams) and thickening stabilizing agent 350 grams (comprise modified starch 325.5 grams, sodium alginate 24.5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15-35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Embodiment 18 contains the preparation method of DHA150g/kg emulsion:
Take by weighing compound lard 429 grams of 35% docosahexenoic acid content, antioxidant 20 grams (comprise natural Vitamin E 0.2 gram, sodium ascorbate 0.1 gram, tea polyphenols 0.2 gram), fruit glaze agent 10 grams (comprise Oleum Helianthi 5 grams, Petiolus Trachycarpi oil 5 grams), oil phase emulsifier 130 grams (comprise lecithin 56 grams, 74 gram span 20s), their limit heating edge are mixed, treat that temperature rises to 55 ℃, be transferred to central (75 ℃ of changes of the water temperature material 40min of water immediately, be cooled to 55 ℃ then), aqueous phase contains aqueous emulsifier phase 29 grams (comprising citric acid fatty glyceride 10.8 grams, 18.2 gram polysorbate65s), and dispersant 55 grams (comprising sucrose 55 grams) and thickening stabilizing agent 75 grams (comprise modified starch 70 grams, sodium alginate 5 grams), be supplemented to total amount 1000 grams with deionized water.Slowly add, stir while adding, after the entry to be completely, use high-speed shearing machine that mixture is carried out emulsifying just, shear rate is controlled at 5600 rev/mins, time 36min, change in the high pressure homogenizer homogenizing three times, pressure 15--35Mpa then over to, obtain the more stable docosahexenoic acid emulsion of white, packing makes finished product.
Among the above-mentioned preparation embodiment, except that docosahexaenoic acid grease and water, other one or more compositions in the allied substances that other kinds material all can be enumerated substitute, and all can obtain stable emulsion, consider that stablizing effect is better, advise composite with two or more composition.
Among the above-mentioned preparation embodiment, temperature, time, shear rate that technological parameter (condition) is included all can make stable emulsion, consider that stablizing effect is better, and preferred intermediate parameters is as preferable condition.
The DHA emulsion of above-mentioned preparation is used for medicine, health product, cosmetics and food, directly adds, or uses with common interpolation of other batchings.
Join in the food, as liquid milk, fruit drink, fruit jelly, ice cream, coffee, offering needs the crowd who replenishes DHA to use.
Wherein the crowd of indication includes but not limited to infant, child, teenager, anemia of pregnant woman or women breast-feeding their children.
The direct interpolation of indication is meant in view of homodisperse performance in the good water of emulsion, can directly add with main mixing of materials in batching, and need not special uniform mixing course of dissolution.
The application of embodiment 19 docosahexenoic acid emulsion in yoghourt (application of docosahexenoic acid emulsion in yoghourt that makes by embodiment 1):
It is as follows to fill a prescription:
Fresh milk 650Kg
Whole milk powder 104.2Kg
White sugar 125Kg
Stabilizing agent 9Kg
Yoghourt essence 400ml
Strain 200U
Docosahexenoic acid emulsion 3Kg
200Kg purifies waste water
Technological process is as follows:
The application of embodiment 20 dodecahexaenes acid emulsion in plain chocolate (application of docosahexenoic acid emulsion in plain chocolate that makes by embodiment 1):
It is as follows to fill a prescription:
Fresh milk 600Kg
Whole milk powder 65Kg
White sugar 3.0Kg
Stabilizing agent (FM-1000) 2.0Kg
Milk flavour (CH101) 100ml
Milk flavour (00076) 100ml
Docosahexenoic acid emulsion 3Kg
Add water to 1000Kg
Technological process is as follows:
The application of embodiment 21 dodecahexaenes acid emulsion in the nutrition cable release (application of docosahexenoic acid emulsion in the nutrition cable release that makes by embodiment 2):
It is as follows to fill a prescription:
Whole milk powder 32Kg
White sugar 65Kg
Protein sugar 0.65Kg
Wheat protein powder 80 3Kg
Stabilizing agent 4.5Kg
Citric acid 2.0Kg
Sodium citrate 0.5Kg
Concentrated Succus Mali pumilae 15Kg
Milk flavour 0.3Kg
Docosahexenoic acid emulsion 3Kg
Add water to 1000Kg
Technological process is as follows:
Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; although the present invention is had been described in detail with reference to preferred embodiment; those of ordinary skill in the art is to be understood that; can make amendment or be equal to replacement technical scheme of the present invention; and not breaking away from the spirit and scope of technical solution of the present invention, it all should belong to protection scope of the present invention.
Claims (10)
1. micrometre level docosahexaenoic acid emulsion comprises:
(A) docosahexenoic acid 50g～150g;
(B) fruit glaze agent 10g-50g;
(C) oil phase emulsifier 14g-130g;
(D) aqueous emulsifier phase 8g-50g;
(E) thickening stabilizing agent 75g-350g;
(F) dispersant 10g-100g;
(G) antioxidant 0.5g-20g;
(H) add water to 1000g.
2. emulsion according to claim 1 is characterized in that: oil phase emulsifier is a kind of in soybean lecithin, sorbester p18, sorbester p17, sorbester p37, monoglyceride, polyglycerin ester, the sodium stearoyl lactate, or two kinds and two or more; Aqueous emulsifier phase is a kind of in citric acid fatty glyceride, polysorbate40, polysorbate60, Tween 80, sucrose fatty acid ester, diacetyl tartarate fatty glyceride, the sodium caseinate, or two kinds and two or more.
3. emulsion according to claim 1 and 2 is characterized in that: thickening stabilizing agent is a kind of in modified starch, xanthan gum, pectin, agar, beta-schardinger dextrin-, sodium alginate, gelatin, chitosan, the modified cellulose, or two kinds and two or more.
4. emulsion according to claim 1 and 2 is characterized in that: fruit glaze agent is a kind of in Oleum Arachidis hypogaeae semen, Oleum Cocois, Oleum Helianthi, Petiolus Trachycarpi oil, the soybean oil, also can be two or more.
5. emulsion according to claim 1 and 2 is characterized in that: antioxidant is a kind of in natural VE, ascorbyl palmitate, sodium ascorbate, tertiarybutylhydroquinone, tea polyphenols, the Herba Rosmarini Officinalis, or two kinds and two or more.
6. the preparation method of the docosahexenoic acid emulsion of one of claim 1～5, step is:
1) oil phase part: after by above-mentioned weight ratio concentration being higher than 30% docosahexaenoic acid grease and adding oil phase emulsifier, fruit glaze agent, antioxidant, oil bath is heated to 40～70 ℃, makes it dissolving, makes the oil phase product A;
2) aqueous portion: by above-mentioned weight ratio aqueous emulsifier phase, stabilizing agent, dispersant are added in the entry, fully stir, be heated to 60～90 ℃, keep 20～60min, make the water product B;
3) treat that water product B temperature reduces to 40～70 ℃, A is slowly joined among the B, carry out emulsifying just, obtain products C with high-speed shearing machine;
4) products C is carried out the pressure homogenizing, obtain product D;
5) with obtaining product E after product D sterilization, the cooling, be docosahexenoic acid emulsion.
7. the preparation method of emulsion according to claim 6 is characterized in that: process for sterilizing employing pasteurize wherein, ultra high temperature short time sterilization, and interpolation antistaling agent anti-rot and fresh-keeping method.
8. according to the preparation method of claim 6 or 7 described emulsion, it is characterized in that: it is 2000～10000 rev/mins that high-speed shearing machine carries out first emulsifying rotating speed, and the time is 10～60 minutes.
9. according to the preparation method of claim 6 or 7 described emulsion, it is characterized in that: wherein need twice pressure homogenizing at least, wherein at least homogenization pressure is more than 200MPa.
10. the purposes of micrometre level docosahexaenoic acid emulsion, micrometre level docosahexaenoic acid emulsion is used for medicine, cosmetics, health product and food, directly adds, or uses with common interpolation of other batchings, and addition accounts for 0.05～2.5% of gross weight.
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Application publication date: 20080910 Assignee: Meitek (Qingdao) Co., Ltd. Assignor: Hubei Fuxing Biological Technology Co., Ltd. Contract record no.: 2012370000211 Denomination of invention: Micrometre level docosahexaenoic acid emulsion and preparation thereof Granted publication date: 20110525 License type: Exclusive License Record date: 20120906 |