CN100594912C - Preparation of beauty gel for treating acne and preparing method - Google Patents

Abstract

The invention relates to a medicament prepared by Chinese drugs and western medicines and used for treating acne by beautifying gel. The raw materials contain clindamycin hydrochloride, ciprofloxacin,dyclonine hydrochloride, 95 percent ethanol, fresh aloe, glycerin, carboxymethyl cellulose and water for injection. The medicament of the invention fully develops the effective ingredients of the Chinese and the western medicines, all the ingredients are mutually increased in efficacies and complemented. The invention is used for treating acne, with obvious effect and evident curative effect.

Description

Medicament of a kind of beauty gel for treating acne and preparation method thereof

Technical field

The present invention relates to a kind of medicament for the treatment of acne, be specifically related to the medicament and preparation method thereof of the beauty gel for treating acne of a kind of Chinese medicine and western medicine preparation.

Background technology

Acne is teenager commonly encountered diseases, frequently-occurring disease, and also there is generation in the middle age.Clinical manifestation be hoary hair's acne, Comedones, inflammatory pimple, Secondary cases abscess, cyst or tuberosity, sore, if itching to infect to stay cicatrix, influences appearance and physical and mental health.Treatment means mostly is medicine for external use, oral medicine, or oral medicine combines with medicine for external use, also adopt the physical method treatment, but therapeutic effect is undesirable generally, and more with the back untoward reaction, injured skin, or be of no curative effect substantially.Chinese patent file CN1528343 discloses a kind of medicament and method for making thereof that contains rare earth treatment acne, the medicament component is cerium chloride, EDTA, methionine, vitamin, vitamin E, Clindamycin Hydrochloride, phenol, benzoic acid, resorcinol, salicylic acid, second alcohol and water, and this medicament mainly belongs to western medicine formulation.

Summary of the invention

At the step of prior art, the present invention provides a kind of and takes effect obviously by theory of integrated Chinese and western medicine and clinical trial, and therapeutic effect is treated medicament of acne and preparation method thereof significantly.

Technical scheme of the present invention is as follows:

A kind of medicament for the treatment of acne, raw material components is as follows:

Clindamycin Hydrochloride 5-15 weight portion, ciprofloxacin 5-15 weight portion, dyclonine hydrochloride 1-2 weight portion, 95% ethanol 100-300 parts by volume, fresh aloe 90-120 weight portion, glycerol 40-50 weight portion, carboxymethyl cellulose 25-35 weight portion, water for injection 500-1500 parts by volume; Wherein, when unit of weight was gram (g), volume unit was a milliliter (ml), and when unit of weight was kilogram (Kg), volume unit was liter (L).

Preferably, a kind of medicament for the treatment of acne, raw material components is as follows:

Clindamycin Hydrochloride 10 grams; Ciprofloxacin 10 grams; Dyclonine hydrochloride 1 gram; 95% ethanol 200ml; Fresh aloe 100 grams; Glycerol 50 grams; Carboxymethyl cellulose 30 grams; Water for injection 1000ml.

The medicaments preparation method of treatment acne of the present invention comprises the following steps:

(a) fresh aloe leaf water soak at room temperature is 20-24 hour, and the Aloe after the immersion drains peeling, squeezes and makes Aloe juice;

(b) carboxymethyl cellulose is added the injection water dissolve rubber cement shape solution, dyclonine hydrochloride is made into 1% solution and joins in this carboxymethyl cellulose solution, add 95% ethanol again and stir;

(c) Clindamycin Hydrochloride and ciprofloxacin are added the dissolving of injection water and mix after, add in the solution that step (b) makes, glycerol is added stir again;

(d) Aloe juice that step (a) made adds in the solution that step (c) makes, be stirred to lather collapse after, add water for injection to 1000 volume unit, stir abundant mixing; Disappear behind the foam, divide to install in the disinfectant vial.

The present invention is the new medicament with the more efficiently treatment acne of other effective ingredient preparations such as the mould phosphate ester of crin, Aloe, give full play to the effect of Chinese and western medicine medicine effective ingredient, each component plays potentiation, complementary action, brings out the best in each other, and is used for the treatment of acne and takes effect obviously, and therapeutic effect is remarkable.

The clinical operating position of medicament that the present invention treats acne is as follows:

1. clinical data

1.1 case is selected: selected patient is all from the department of dermatologry outpatient service of First People's Hospital, Jining, through the acne patient of clinical definite.Eliminating has allergies person to clindamycin, Quinolones, uses other anti-acne medicines person in 15 days, serious hepatic and kidney function obstacle person, and anemia of pregnant woman women breast-feeding their children.

1.2 grouping: 129 routine patients are adopted multicenter open parallel control observational technique, be divided into experimental group, matched group.Experimental group: 84 people, male 38 people; Women 46 people, age 23a+-5a.Matched group: 45 people, male 23 people; Women 22 people, age 22.5a+-4a.Every desired values such as age-sex, stadium and skin lesion degree are compared between 2 groups, and difference does not all have clear meaning (P＜0.05), has comparability.

2. experimental statistics data

2.1 experimental technique: experimental group: give the medicament external of beauty gel for treating acne of the present invention; Matched group: give 5% sulfur frost (Drug Manufacturing Room of People Hospital No.1, Jining City making) external.Administrated method: wash one's face with warm water and soap lye or sulfur medicated soap, facial putty is fully clean, and the reuse finger dips in medicine, is applied in the affected part repeatedly gently, and respectively smear once every day sooner or later, and continuous 2 weeks are a course of treatment.To light moderate patient medicine for external use only, and give antibiotic+medicine for external use to the severe patient.It is all consistent that experimental group and matched group give antibiotic kind, usage, dosage.

2.2 observation of curative effect and criterion: the 129 example ginseng persons of grinding per 2 all follow-up observations once during further consultation, are filled in the observation form, record patient facial acne skin lesion number, variation and untoward reaction in detail.Add up curative effect by total percentage rate that the various infringements of acne (acne, inflammatory herpes, abscess, tuberosity, cyst) reduce.

Recovery from illness: skin lesion disappears 100%; Produce effects: the skin lesion 76-99% that disappears; Effectively: the skin lesion 50-70% that disappears; Invalid: skin lesion disappears＜and 50%.After finishing the course of treatment, calculate the percent for the treatment of the back acne, carry out the curative effect assessment with metering method.Simultaneously, untoward reaction is observed, observation has or not local excitation and General Symptoms, makes hematuria routine examination regulating liver-QI, kidney function test before and after the experiment of part patients clinical.

2.3 contrast curative effect statistical analysis: experimental group: 84 examples, 45 examples of fully recovering account for 53.6%, and produce effects 21 examples account for 25%; Effective 17 examples account for 20%; Invalid 1 example accounts for 1.4%; Total effective rate 98.6%.Matched group: 45 examples, 3 examples of fully recovering account for 6%; Produce effects 8 examples account for 18%; Effective 10 examples account for 22%; Invalid 2 examples account for 4.4%; Total effective rate 46%.

Contrast efficacy analysis [example (%)] gets X2=58.62, X20.01[2 through the X2 check]=9.21 event P＜0.01, difference has highly significant, and the illustrative experiment group is better than matched group to treatment acne curative effect.

2.4 untoward reaction

Experimental group: 84 examples do not have 1 routine untoward reaction.

Matched group: local burning sensation behind the 2 routine coatings is arranged, and after the flushing drug withdrawal, spontaneous remission does not deal with.In addition, 15 routine hematuria routines, 8 routine liver functions, 2 routine kidney function test, all no abnormal change have been observed before and after the treatment altogether.

2.5 model case: Korea Spro X, woman, 21 years old, because of 2 years companions of facial rash causalgia is gone to a doctor the training inspection: denomination, cheeks side grain of rice size acne, pimple, and a small amount of pustule is arranged, several 45 of total erythra, diagnosis: acne, it is all normal to do hematuria routine examination and liver function test, give beauty gel each 1 external sooner or later, the skin lesion degree alleviates after 2 days, after 5 days, and erythra decreased number 50%, after 10 days, erythra all disappears.After treating the end course of treatment, have a blood test routine urinalysis and liver function are still no abnormal.

The specific embodiment

Embodiment 1:

A kind of medicament for the treatment of acne, the raw material components weight portion is as follows:

Clindamycin Hydrochloride 10 grams; Ciprofloxacin 10 grams; Dyclonine hydrochloride 1 gram; 95% ethanol 200ml; Fresh aloe 100 grams; Glycerol 50 grams; Carboxymethyl cellulose 30 grams; Sterilized water for injection 1000ml.

The preparation method step is as follows:

(a) fresh aloe leaf 100 gram water soak at room temperature are 24 hours, and the Aloe after the immersion drains peeling, squeezes to make the Aloe juice Colloidal fluid;

(b) carboxymethyl cellulose 30 gram is added the injection water dissolve rubber cement shape solution, dyclonine hydrochloride is made into 1% solution and joins in this carboxymethyl cellulose solution, add 95% ethanol 200ml again and stir;

(c) Clindamycin Hydrochloride 10 gram and ciprofloxacin 10 grams added the dissolving of injection water mix after, add in the solution that step (b) makes, again glycerol 50 grams are added stirring;

(d) Aloe juice that step (a) made adds in the solution that step (c) makes, be stirred to lather collapse after, add water for injection to total amount 1000ml, stir abundant mixing; Disappear behind the foam, divide to install in the disinfectant vial.

Embodiment 2:

A kind of medicament for the treatment of acne, the raw material components weight portion is as follows:

Clindamycin Hydrochloride 6 grams; Ciprofloxacin 6 grams; Dyclonine hydrochloride 1 gram; 95% ethanol 120ml; Fresh aloe 90 grams; Glycerol 40 grams; Carboxymethyl cellulose 25 grams; Sterilized water for injection 800ml.

Preparation method is with embodiment 1.

Embodiment 3:

A kind of medicament for the treatment of acne, the raw material components weight portion is as follows:

Clindamycin Hydrochloride 15 grams, ciprofloxacin 15 grams, dyclonine hydrochloride 2 grams, 95% ethanol 250ml, fresh aloe 120 grams, glycerol 50 grams, carboxymethyl cellulose 35 grams, water for injection 1500ml.

Preparation method is with embodiment 1.

Claims (3)

1, a kind of medicament for the treatment of acne is characterized in that raw material components is as follows:

Clindamycin Hydrochloride 5-15 weight portion, ciprofloxacin 5-15 weight portion, dyclonine hydrochloride 1-2 weight portion, 95% ethanol 100-300 parts by volume, fresh aloe 90-120 weight portion, glycerol 40-50 weight portion, carboxymethyl cellulose 25-35 weight portion, water for injection 500-1500 parts by volume; Wherein, when unit of weight was gram (g), volume unit was a milliliter (ml), and when unit of weight was kilogram (Kg), volume unit was liter (L).

2, the medicament of treatment acne as claimed in claim 1 is characterized in that raw material components is as follows:

Clindamycin Hydrochloride 10 grams; Ciprofloxacin 10 grams; Dyclonine hydrochloride 1 gram; 95% ethanol 200ml; Fresh aloe 100 grams; Glycerol 50 grams; Carboxymethyl cellulose 30 grams; Water for injection 1000ml.

3, the medicaments preparation method of the described treatment acne of a kind of claim 1, step is as follows:

(a) fresh aloe leaf water soak at room temperature is 20-24 hour, and the Aloe after the immersion drains peeling, squeezes and makes Aloe juice;

(b) carboxymethyl cellulose is added the injection water dissolve rubber cement shape solution, dyclonine hydrochloride is made into 1% solution and joins in this carboxymethyl cellulose solution, add 95% ethanol again and stir;

(c) Clindamycin Hydrochloride and ciprofloxacin are added the dissolving of injection water and mix after, add in the solution that step (b) makes, glycerol is added stir again;

(d) Aloe juice that step (a) made adds in the solution that step (c) makes, be stirred to lather collapse after, add water for injection to 1000 volume unit, stir abundant mixing; Disappear behind the foam, divide to install in the disinfectant vial.