CN100553661C - A kind of medicine for the treatment of thromboangiitis obliterans of lower limb and preparation method thereof - Google Patents
A kind of medicine for the treatment of thromboangiitis obliterans of lower limb and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of medicine for the treatment of thromboangiitis obliterans of lower limb, it mainly is to be prepared from according to a certain weight ratio by crude drug such as the Radix Linderae, Radix Aconiti Lateralis Preparata, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Astragali, Radix Angelicae Pubescentis, Squama Manis preparatas, it can be prepared into any dosage form for oral administration commonly used, medicine of the present invention has thrombolytic, eliminating stasis to stop pain, sterilization functions of expelling toxin, the treatment thromboangiitis obliterans, instant effect, cure rate height.
Description
Technical field:
The present invention relates to a kind of medicine for the treatment of thromboangiitis obliterans of lower limb and preparation method thereof, belong to the field of Chinese medicines.
Background technology:
Thromboangiitis obliterans is one of lower limb commonly encountered diseases, and clinical toes are livid purple to suffer from the long-term low temperature of limb, and the swelling of the instep back of the body is feature, swelling aggravation during outbreak, pain unbearably, the patient suffers untold misery.Western medical treatment many with antiinflammatory, relieve the pain, spasmolytic, thrombolytic, expansion microcirculation, to alleviate the progress of the course of disease.But the treatment of these medicines also can only be to cure the symptoms, not the disease, and can not effect a radical cure, and as obstinate, outbreak then must be abandoned limb and be kept tie peace repeatedly.
Summary of the invention:
Therefore people exist the better Chinese medicine preparation of curative effect and crave for more greatly, up to now, also do not find the report of the Chinese medicine medicine of any relevant treatment thromboangiitis obliterans.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, works out the oral medicinal herb medicine of the treatment thromboangiitis obliterans of lower limb with better curative effect finally, thereby has finished the present invention.
Purpose of the present invention just provides a kind of a kind of Chinese medicine composition with better curative effect treatment thromboangiitis obliterans.
Another object of the present invention has just provided the preparation method of this Chinese medicine composition.
The medicament selection Radix Linderae of the present invention, Radix Aconiti Lateralis Preparata, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Radix Astragali, Radix Angelicae Pubescentis, Squama Manis preparata, Bulbus Fritillariae taipaiensis, Fructus Chaenomelis, Radix Ephedrae, Carapax et Plastrum Testudinis, Radix Clematidis, Radix Glycyrrhizae, Myrrha, Olibanum, Flos Carthami, Semen Persicae, Rhizoma Pinelliae Preparatum, Leptoradix Ginseng Rubra make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of thromboangiitis obliterans.Wherein selecting the Radix Linderae for use is because of its nature and flavor suffering, temperature, goes into spleen, lung, kidney, urinary bladder channel.Have pleasant, dissipating depression of QI, cold expelling, the effect of pain relieving.Control the QI rising in reverse order chest and abdomen swelling and pain, dyspepsia does not disappear, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.Select for use Radix Aconiti Lateralis Preparata to be because its property acrid-sweet flavor, heat,, go into heart spleen, kidney channel, have recuperating depleted YANG to mend the function of fiery dispelling cold and removing dampness.Control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, anemofrigid-damp arthralgia, Wei lame Chinese holly contraction, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Selecting Radix Rehmanniae Preparata for use is that tepor is gone into liver, kidney channel because of its nature and flavor sweetness and bitterness.Has YIN nourishing, the effect of enriching blood.Control deficiency of YIN insufficiency of blood, a little less than the waist lacquer fistula, the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.(exsiccant angelica root can be divided into 3 ones: the root head claims " returning head ", and main root claims " returning body " to select Radix Angelicae Sinensis for use, supporting root and supporting root taper claim " Radix Angelicae Sinensis ") be that temperature is gone into the heart, liver, spleen channel because of the sweet suffering of its nature and flavor, has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation.Control menoxenia, amenorrhea stomachache, the lump in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, fistula numbness; The dryness of the intestine dyschezia is heavy after the bloody dysentery; Ulcer sores, traumatic injury.The Radix Astragali, the different name Radix Astragali.Select for use the Radix Astragali to be because its nature and flavor are sweet, tepor is gone into lung, spleen channel.Give birth to and use: benefit is defended consolidating superficial resistance, inducing diuresis to remove edema, poison holding, granulation promoting.Control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and do not hold back for a long time.Process usefulness: invigorating the spleen and replenishing QI, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, and the disease of all weakness of QI blood deficiency.Select for use Radix Angelicae Pubescentis to be because its nature and flavor are arduous, temperature is gone into kidney, urinary bladder channel.Have and dispel the wind, win and wet, cold expelling, pain relieving.Control anemofrigid-damp arthralgia, soreness of waist and knee joint, trick spasm and pain, chronic tracheitis, headache, toothache.Select for use Squama Manis preparata to be because its nature and flavor are salty, liver, stomach warp are gone in cold.Have the routed carbuncle of detumescence, it is active to search wind, the stimulating milk secretion of stimulating the menstrual flow.It is swollen to control the carbuncle skin ulcer, and anemofrigid-damp arthralgia has through closing down galactostasis.Select for use Bulbus Fritillariae taipaiensis to be because its property bitter but sweet flavor is slightly cold.Have lung moistening, reduce phlegm, the effect of cough-relieving.Control the cough due to lung-heat, bronchitis, expectoration is unfavorable.Selecting Fructus Chaenomelis for use is that temperature is gone into lung, spleen channel because of its nature and flavor acid.Suppressing the hyperactive liver and easing the stomach, Shujin dries.Control the convulsion of vomiting and diarrhoea, arthralgia chiefly caused by damp pathogen, beriberi, edema, dysentery.Select for use Radix Ephedrae to be because its property sweet and slightly bitter taste is flat.Control the empty spontaneous perspiration of body, night sweat.Select for use Carapax et Plastrum Testudinis to be because its nature and flavor are salty sweet, flat, go into liver, kidney channel.Has YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, the effect of strong bone.Control deficiency of kidney yin, the hectic fever due to YIN-deficiency consumptive fever is spitted blood, epistaxis, and chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, bone fistula, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants has the merit in through vola.Select for use Radix Clematidis to be because its nature and flavor suffering is salty, temperature is gone into urinary bladder channel.Has wind-damp dispelling, the meridian dredging, expectorant saliva, the effect of the hypochondriac lump of loosing.Control gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select for use Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, go into spleen, stomach, lung meridian.Have and middle emergency lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.Process usefulness, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, pulmonary fistula cough, cardiopalmus, infantile convulsion; Give birth to usefulness, control laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select for use Myrrha to be because its nature and flavor hardship is flat, go into Liver Channel.Has diffusing blood blood stasis removing, the effect of subduing swelling and relieving pain.Control and fall damage, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Select for use Olibanum to be because its nature and flavor are arduous, temperature is gone into the heart, liver, spleen channel, has regulating qi and activating blood, and analgesic therapy chases after the effect of poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Selecting Flos Carthami for use is that temperature is gone into the heart, Liver Channel because of its nature and flavor suffering.Has promoting blood circulation to restore menstrual flow, the effect of blood stasis removing pain relieving.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, traumatic injury.Select for use Semen Persicae to be because its property bitter but sweet flavor is flat, go into the heart, liver, large intestine channel.Blood stasis removing and clots absorbing is moisturized laxation.Control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Selecting Rhizoma Pinelliae Preparatum for use is because of its nature and flavor suffering, and temperature is poisonous, goes into spleen, stomach warp.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control the damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, septum pectorale distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness.Radix Ginseng mainly is divided into Radix Ginseng Rubra class, Radix Ginseng (processed with sugar) class, Radix Ginseng etc. through processing, and Leptoradix Ginseng Rubra is to get its afterbody.Selecting Leptoradix Ginseng Rubra for use is that temperature is gone into spleen, lung meridian because of its property sweet and slightly bitter taste.Strongly invigorating primordial QI promotes the production of body fluid admittedly take off, and calms the nerves.It is deficient to control impairment caused by overstrain, lack of appetite, and asthenia, food is told in regurgitation, the stool lingering diarrhea, empty cough with asthma is short, the spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition is quenched one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion, and prolonged deficiency is not multiple, the disease of all qi-blood-body fluid deficiencies.
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following weight range:
Radix Linderae 5-10 gram Radix Aconiti Lateralis Preparata 8-12 gram Radix Rehmanniae Preparata 10-15 gram
Radix Angelicae Sinensis 20-30 gram Radix Astragali 15-25 gram Radix Angelicae Pubescentis 10-15 gram
Squama Manis preparata 10-20 gram Bulbus Fritillariae taipaiensis 10-15 gram Fructus Chaenomelis 8-12 gram
Radix Ephedrae 8-12 gram Carapax et Plastrum Testudinis 35-45 gram Radix Clematidis 10-15 gram
Radix Glycyrrhizae 10-15 gram Myrrha 10-15 gram Olibanum 1015 grams
Flos Carthami 5-10 gram Semen Persicae 5-10 gram Rhizoma Pinelliae Preparatum 5-10 gram
Leptoradix Ginseng Rubra 10-15 gram.
Be preferably: the Radix Linderae 6 grams, Radix Aconiti Lateralis Preparata 10 grams, Radix Rehmanniae Preparata 12 grams, Radix Angelicae Sinensis 25 grams, the Radix Astragali 20 grams, Radix Angelicae Pubescentis 12 grams, Squama Manis preparata 15 grams, Bulbus Fritillariae taipaiensis 12 grams, Fructus Chaenomelis 10 grams, Radix Ephedrae 10 grams, Carapax et Plastrum Testudinis 40 grams, Radix Clematidis 12 grams, Radix Glycyrrhizae 12 grams, Myrrha 12 grams, Olibanum 12 grams, Flos Carthami 6 grams, Semen Persicae 6 grams, Rhizoma Pinelliae Preparatum 6 grams, Leptoradix Ginseng Rubra 12 grams.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into the Oral preparation of any routine, for example these crude drug pulverize mix homogeneously can be made powder and take after mixing it with water or make the decoction drink-service.
The preparation method of drug component of the present invention comprises the following steps:
One, the process of preparing Chinese medicine of crude drug:
1, the Radix Linderae is chosen decontamination, size bar separately, and water soaks, and according to noting changing water season, prevents smellyly, in time pulls section out.Scrape off cork, section, oven dry.
2, Radix Aconiti Lateralis Preparata is got Radix Aconiti Lateralis Preparata, soaks with clear water and floats, change water 2-3 every day, rinses to saline, puts in the pot to add water with well-done with Radix Glycyrrhizae, Semen sojae atricolor, after cutting, mouth is tasted has spicy sense to be degree slightly, takes out and removes Radix Glycyrrhizae, Semen sojae atricolor, scrape peeling and be cut to two lobes, put and added decocting in water in the pot about 2 hours, take out dry in the sun, moistening after running through, is cut skin and is dried for several times repeatedly, 100 jin of every Radix Aconiti Lateralis Preparata are with 5 jin in Radix Glycyrrhizae, 10 jin in Semen sojae atricolor.
3, Radix Rehmanniae Preparata is got Radix Rehmanniae and is added yellow wine 30%, mixes and stirs, and goes in the steaming device, steam to inside and outside black profit, takes out to dry.Or get Radix Rehmanniae and put in the steaming device and to steam after 8 hours, climb over next day and steam 4～8 hours a more stewing night, take out a stewing again night, shine to eighty per cant and do, after the section, dry again.
4, Radix Angelicae Sinensis is chosen decontamination, cleans, and dries in the air slightly to inside and outside humidity when suitable, gets the afterbody of its Radix Angelicae Sinensis, and section is dried.
5, the Radix Astragali is chosen decontamination, removes residual root head and hollow the greater, is soaked in water, and pulls out, runs through back section in time, dries.
6, Radix Angelicae Pubescentis is chosen decontamination, and separately size is individual, cleans, and runs through the back section, drying.
7, Squama Manis preparata is got the Squama Manis sheet of choosing clean, and separately size is put sand in addition and fried in the pot to easily, adds the Squama Manis sheet, fries to heaving when being golden yellow, takes out, and sieve shakeout cools, and medication is beaten broken.
8, Bulbus Fritillariae taipaiensis is excavated to put in the Testa Tritici and dry in the shade May, and the reuse sulfur is smoked, and medication is beaten broken.
9, Fructus Chaenomelis, clear water are cleaned, and soak slightly, and moistening is to saturating, put in the food steamer to cook, and take advantage of fervent sheet, and order shines night dew, with by red commentaries on classics atropurpureus degree of being.
10, Radix Ephedrae is chosen decontamination, removes residual stem, is soaked in water, and pulls out, runs through the back section, dries.
11, Carapax et Plastrum Testudinis soaks with clear water, scrapes off residual meat, cleans, dry, and the knock fritter, medication is beaten broken.
12, Radix Clematidis is chosen clean impurity, removes residual stem, is soaked in water, and pulls out to run through, and cutting is dried.
13, Radix Glycyrrhizae chooses decontamination, cleans, and is soaked in water to eighty per cant when saturating, pulls out, runs through section, dries.
14, Myrrha is chosen decontamination, breaks fragment.
15, Olibanum is chosen the sub-impurity of shakeout.
16, Flos Carthami is chosen clean roguing, removes stem and leaf, base of a fruit head, dries.
17, Semen Persicae is removed duricrust impurity, puts and boils in the boiling water pot to the little wrinkle of crust, pulls out, immerses in the cold water, rubs with the hands and removes kind of a skin, dries, and it is clean to winnow with a dustpan.
18, Rhizoma Pinelliae Preparatum is got the clean Rhizoma Pinelliae, soaks with cold water and floats, and avoids Exposure to Sunlight, and according to its place of production quality and granular size thereof, consideration adjustment is soaked number of days.Behind the bubble to 10 day, when playing foam, every Rhizoma Pinelliae adds 2 jin of Alumens for 100 jin, steep and changes water again after 1 day, and tasting to mouth has spicy sense to be degree slightly, and taking-up is slightly dried in the air.Extracting liquorice grinds into thick piece in addition, adds decocting soup, steeps lime block with glycyrrhiza decoction, adds water again and mixes, and removes lime mud, pours in the Rhizoma Pinelliae cylinder and soaks, and stir every day.(100 jin of every Rhizoma Pinelliaes are with 2 jin of Alumens, 16 jin in Radix Glycyrrhizae, 20 jin of lime blocks)
19, Leptoradix Ginseng Rubra removes removing LU, dries cutting.
Two, preparation:
1, the preparation of powder: said medicine is pulverized mix homogeneously, and porphyrize powder altogether is the powder of medicine of the present invention after 200 mesh sieves, and the powder of porphyrize is packed in the medicine bottle.
2, the preparation of decoction: get that above-mentioned materials of weight proportions medicine is put into porcelain or earthen container adds 1500 milliliters in warm water, soak after 2 hours and decoct, leach 250 milliliters of medicinal liquids, medicinal residues add 1000 milliliters of decoctions of water again, filter 200 milliliters of medicinal liquids, medicinal residues add 800 milliliters in water again, filter 150 milliliters of medicinal liquids.Wherein Leptoradix Ginseng Rubra is treated to put into when water boils container again and is decocted when secondary decocts with water, and three 600 milliliters of taking liquids altogether mix a place, and five equilibrium is adult's daily dose for three parts.
Medicine of the present invention has significant antiinflammatory, thrombolytic, eliminating stasis to stop pain, sterilization, function of detoxification, and the draft class is used root entirely, establishes descending power, can strengthen the human body immunity, enhances metabolism, and effectively treats the recurrence of thromboangiitis obliterans.
The specific embodiment:
Below further sets forth the beneficial effect of medicine of the present invention by testing example, these are tested the routine animal toxicity test of medicine of the present invention and the clinical observation on the therapeutic effect of having comprised and test.
[test example 1] animal toxicity test
Get 20 of new zealand rabbits, the male and female dual-purpose, body weight 2.0-2.5 kilogram is divided into 2 groups, and 10 every group, wherein one group is the toxicity trial group of excess, and another group is the toxicity trial group of normal amount.
Adopt the administration by gavage administration: excess group dosage is a per kilogram of body weight with 6 milliliters of medicinal liquids, and normal amount group dosage is a per kilogram of body weight with 3.4 milliliters of medicinal liquids, and every day, secondary serve on 7 days, observes two groups of rabbit response situation after the medication every day.
After the excess group is taken medicine, in 10 rabbit, wherein have 2 doe looks dull in three days, inappetence recovered normal later in two and a half hours.After three days, 2 does do not have any abnormal response yet.After the normal amount group was taken medicine, 10 rabbit groups did not have any untoward reaction, and the result shows that medicine of the present invention uses without any side effects in the normal amount scope.
The clinical observation material of [test example 2] Drug therapy thromboangiitis obliterans of the present invention.
1, physical data: accept out-patient's totally 36 examples for medical treatment, wherein male 24 examples, women 12 examples, age 10-20 year 4 examples, 21-30 year 5 examples, 31-40 year 9 examples, 41-50 year 13 examples, 5 examples more than 50 years old.
2, diagnostic criteria: thromboangiitis obliterans belongs to surgery of Chinese medicine skin infection category, because of wind and cold invasion and attack human body, vigour loss, decline of the fire from the gate of life and cause gasification imbalance, the nutrient blood retardance, meridians are jammed, so that local nutrient blood loses nourishing, defend gas and lose and defend admittedly, thereby suffer from the long-term low temperature of limb, going into the winter doubly trembles with fear, the affected part that continues is given birth to hot swelling, aches night and is insomnia limitation of activity, protracted course of disease clinically is divided into three types.
Initial period: the big footwear of conscious foot are little, the time heavy when light, the affected part is with heating paresthesia, general healing 1-2 the course of treatment.
The secondary phase: suffer from phalanx joint pain, the stiff swollen distortion in joint, local skin swelling, diabrosis, protracted course of disease, and with General Symptomies such as heatings.
The serious symptom phase: affected part partial musculature and angionecrosis, skin ulceration, through what is called: the gesture of cold in an extreme giving rise to heat becomes, and it is useless to advance to burst.Beginning has whole body disease, low grade fever, light night in daytime to weigh.
3, Therapeutic Method:
Oral 3 times of every day, 200 milliliters of each oral liquid medicines, ante cibum, one after each meal all can.One month is a course of treatment, and course of treatment of light disease initial period, the secondary phase serve on 2-3 the course of treatment, and the serious symptom phase serve on 3-4 the course of treatment.
Points for attention:
1, period in a medicine diet Carnis Equi Asini, the meat of castrating a pig.
2, period in a medicine stops to use the cold water foot bath, forbids sexual life, absolute bed rest before curing.
3, juvenile careful usefulness below 16 years old, the careful usefulness of hyperpietic, and need the tight blood pressure trend of observing.
4, the anemia of pregnant woman prohibits clothes.
5, cure in the 1-7 of back, from during Waking of Insects (3rd solar term) next year, using hot-water soak both feet 20-30 minute every night from the Beginning of Winter, and forbid using the cold water foot bath.Otherwise must recur in the 1-3.
4, efficacy assessment standard
Produce effects: after oral three courses of treatment, the local organization swelling pain disappears, limb activity freely, function is normal, drug withdrawal does not have recurrence in later six months.
Take a turn for the better: after oral three courses of treatment, local symptom is obviously improved, and skin turgor disappears, the healing of ulceration place, and limb activity does not influence orthobiosis freely, and function is recovered gradually.
Invalid: as not reach improvement standard person
5, therapeutic outcome (seeing the following form)
In above-mentioned chronotherapy, with Drug therapy initial period patient 15 examples of the present invention, produce effects 13 examples as a result, 1 example that takes a turn for the better, invalid 1 example, obvious effective rate is 86.6%, improvement rate is 6.7%, total effective rate 93.3%.Treatment secondary phase patient 11 examples, produce effects 9 examples as a result, 1 example takes a turn for the better, invalid 1 example, obvious effective rate are 81.8%, and improvement rate is 9.1%, total effective rate is 90.9%, serious symptom phase patient 10 examples, produce effects 6 examples as a result, 2 examples that take a turn for the better, invalid 2 examples, obvious effective rate is 60%, invalid 2 examples, obvious effective rate is 60%, and improvement rate is 20%, and total effective rate is 80%.
Claims (4)
1, a kind of medicine for the treatment of thromboangiitis obliterans of lower limb is characterized in that: it is the medicine of being made by the crude drug in the following weight ratio range:
Radix Linderae 5-10 gram Radix Aconiti Lateralis Preparata 8-12 gram Radix Rehmanniae Preparata 10-15 gram
Radix Angelicae Sinensis 20-30 gram Radix Astragali 15-25 gram Radix Angelicae Pubescentis 10-15 gram
Squama Manis preparata 10-20 gram Bulbus Fritillariae taipaiensis 10-15 gram Fructus Chaenomelis 8-12 gram
Radix Ephedrae 8-12 gram Carapax et Plastrum Testudinis 35-45 gram Radix Clematidis 10-15 gram
Radix Glycyrrhizae 10-15 gram Myrrha 10-15 gram Olibanum 10-15 gram
Flos Carthami 5-10 gram Semen Persicae 5-10 gram Rhizoma Pinelliae Preparatum 5-10 gram
Leptoradix Ginseng Rubra 10-15 gram.
2, the medicine of treatment thromboangiitis obliterans of lower limb according to claim 1, wherein the weight proportion of each crude drug is: the Radix Linderae 6 grams, Radix Aconiti Lateralis Preparata 10 grams, Radix Rehmanniae Preparata 12 grams, Radix Angelicae Sinensis 25 grams, the Radix Astragali 20 grams, Radix Angelicae Pubescentis 12 grams, Squama Manis preparata 15 grams, Bulbus Fritillariae taipaiensis 12 grams, Fructus Chaenomelis 10 grams, Radix Ephedrae 10 grams, Carapax et Plastrum Testudinis 40 grams, Radix Clematidis 12 grams, Radix Glycyrrhizae 12 grams, Myrrha 12 grams, Olibanum 12 grams, Flos Carthami 6 grams, Semen Persicae 6 grams, Rhizoma Pinelliae Preparatum 6 grams, Leptoradix Ginseng Rubra 12 grams.
3, the medicine of treatment thromboangiitis obliterans of lower limb according to claim 1 and 2 is characterized in that: described medicament is powder or decoction.
4, according to the preparation method of claim 1,2 or 3 described treatment thromboangiitis obliterans of lower limb medicines, it is characterized in that: it comprises the following steps:
(1) process of preparing Chinese medicine of crude drug:
(1) Radix Linderae is chosen decontamination, size bar separately, and water soaks, and according to noting changing water season, prevents smellyly, in time pulls section out.Scrape off cork, section, oven dry;
(2) Radix Aconiti Lateralis Preparata is got Radix Aconiti Lateralis Preparata, soaks with clear water and floats, change water 2-3 every day, rinses to saline, puts in the pot to add water with well-done with Radix Glycyrrhizae, Semen sojae atricolor, after cutting, mouth is tasted has spicy sense to be degree slightly, takes out and removes Radix Glycyrrhizae, Semen sojae atricolor, scrape peeling and be cut to two lobes, put and added decocting in water in the pot about 2 hours, take out dry in the sun, moistening after running through, is cut skin and is dried for several times repeatedly, 100 jin of every Radix Aconiti Lateralis Preparata are with 5 jin in Radix Glycyrrhizae, 10 jin in Semen sojae atricolor;
(3) Radix Rehmanniae Preparata is got Radix Rehmanniae and is added yellow wine 30%, mixes and stirs, and goes in the steaming device, steam to inside and outside black profit, takes out to dry.Or get Radix Rehmanniae and put in the steaming device and to steam after 8 hours, climb over next day and steam 4～8 hours a more stewing night, take out a stewing again night, shine to eighty per cant and do, after the section, dry again;
(4) Radix Angelicae Sinensis is chosen decontamination, cleans, and dries in the air slightly to inside and outside humidity when suitable, gets the afterbody of its Radix Angelicae Sinensis, and section is dried;
(5) Radix Astragali is chosen decontamination, removes residual root head and hollow the greater, is soaked in water, and pulls out, runs through back section in time, dries;
(6) Radix Angelicae Pubescentis is chosen decontamination, and separately size is individual, cleans, and runs through the back section, drying;
(7) Squama Manis preparata is got the Squama Manis sheet of choosing clean, and separately size is put sand in addition and fried in the pot to easily, adds the Squama Manis sheet, fries to heaving when being golden yellow, takes out, and sieve shakeout cools, and medication is beaten broken;
(8) Bulbus Fritillariae taipaiensis is excavated to put in the Testa Tritici and dry in the shade May, and the reuse sulfur is smoked, and medication is beaten broken;
(9) Fructus Chaenomelis, clear water are cleaned, and soak slightly, and moistening is to saturating, put in the food steamer to cook, and take advantage of fervent sheet, and weather exposure is with by red commentaries on classics atropurpureus degree of being;
(10) Radix Ephedrae is chosen decontamination, removes residual stem, is soaked in water, and pulls out, runs through the back section, dries;
(11) Carapax et Plastrum Testudinis soaks with clear water, scrapes off residual meat, cleans, dry, and the knock fritter, medication is beaten broken;
(12) Radix Clematidis is chosen clean impurity, removes residual stem, is soaked in water, and pulls out to run through, and cutting is dried;
(13) Radix Glycyrrhizae chooses decontamination, cleans, and is soaked in water to eighty per cant when saturating, pulls out, runs through section, dries;
(14) Myrrha is chosen decontamination, breaks fragment;
(15) Olibanum is chosen the sub-impurity of shakeout;
(16) Flos Carthami is chosen clean roguing, removes stem and leaf, base of a fruit head, dries;
(17) Semen Persicae is removed duricrust impurity, puts and boils in the boiling water pot to the little wrinkle of crust, pulls out, immerses in the cold water, rubs with the hands and removes kind of a skin, dries, and it is clean to winnow with a dustpan;
(18) Rhizoma Pinelliae Preparatum is got the clean Rhizoma Pinelliae, soaks with cold water and floats, and avoids Exposure to Sunlight, and according to its place of production quality and granular size thereof, consideration adjustment is soaked number of days.Behind the bubble to 10 day, when playing foam, every Rhizoma Pinelliae adds 2 jin of Alumens for 100 jin, steep and change water again after 1 day, tasting to mouth has spicy sense to be degree slightly, takes out and slightly dries in the air, extracting liquorice grinds into thick piece in addition, adds decocting soup, steeps lime block with glycyrrhiza decoction, add water again and mix, remove lime mud, pour in the Rhizoma Pinelliae cylinder and soak, stir (100 jin of every Rhizoma Pinelliaes every day, with 2 jin of Alumens, 16 jin in Radix Glycyrrhizae, 20 jin of lime blocks);
(19) Leptoradix Ginseng Rubra removes removing LU, dries cutting;
(2) preparation:
(1) preparation of powder: said medicine is pulverized mix homogeneously, and porphyrize powder altogether is the powder of medicine of the present invention after 200 mesh sieves, and the powder of porphyrize is packed in the medicine bottle;
(2) preparation of decoction: get that above-mentioned materials of weight proportions medicine is put into porcelain or earthen container adds 1500 milliliters in warm water, soak after 2 hours and decoct, leach 250 milliliters of medicinal liquids, medicinal residues add 1000 milliliters of decoctions of water again, filter 200 milliliters of medicinal liquids, medicinal residues add 800 milliliters in water again, filter 150 milliliters of medicinal liquids.Wherein Leptoradix Ginseng Rubra is treated to put into when water boils container again and is decocted when secondary decocts with water, three 600 milliliters of taking liquids altogether, mix homogeneously bottling.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006101419287A CN100553661C (en) | 2006-10-01 | 2006-10-01 | A kind of medicine for the treatment of thromboangiitis obliterans of lower limb and preparation method thereof |
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| CNB2006101419287A CN100553661C (en) | 2006-10-01 | 2006-10-01 | A kind of medicine for the treatment of thromboangiitis obliterans of lower limb and preparation method thereof |
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| CN100553661C true CN100553661C (en) | 2009-10-28 |
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| CN101301453B (en) * | 2008-06-23 | 2010-12-22 | 焦太安 | Chinese patent medicine powder for treating hematopathy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1387880A (en) * | 2001-05-25 | 2003-01-01 | 赵忠生 | Blood circulation promoting wine |
| CN1679843A (en) * | 2005-01-27 | 2005-10-12 | 朱腾月 | Oral medicine for treating thromboangitis obliterans |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1387880A (en) * | 2001-05-25 | 2003-01-01 | 赵忠生 | Blood circulation promoting wine |
| CN1679843A (en) * | 2005-01-27 | 2005-10-12 | 朱腾月 | Oral medicine for treating thromboangitis obliterans |
Non-Patent Citations (2)
| Title |
|---|
| 血栓闭塞性脉管炎中医治疗进展. 郑尚雪.中国中医药信息杂志，第2卷第11期. 1995 |
| 血栓闭塞性脉管炎中医治疗进展. 郑尚雪.中国中医药信息杂志，第2卷第11期. 1995 * |
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