CN100376230C - Timing slow-releasing micrpill and its preparation - Google Patents
Timing slow-releasing micrpill and its preparation Download PDFInfo
- Publication number
- CN100376230C CN100376230C CNB2005100552031A CN200510055203A CN100376230C CN 100376230 C CN100376230 C CN 100376230C CN B2005100552031 A CNB2005100552031 A CN B2005100552031A CN 200510055203 A CN200510055203 A CN 200510055203A CN 100376230 C CN100376230 C CN 100376230C
- Authority
- CN
- China
- Prior art keywords
- slow
- layer
- medicine
- timing
- releasing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention provides a preparation method of a timing slow-releasing micro pill which comprises two kinds of basic structures of a basic structure 1 which is composed of blank pill core, a medicine containing layer, a slow-releasing layer, an expansion layer and a timing slow-releasing layer, and a basic structure 2 which is composed of a medicine containing micro pill, a slow-releasing layer, an expansion layer and a timing slow-releasing layer. The blank pill core is taken, and medicine powder, or the solid dispersion of the medicine or the cyclodextrin inclusion compound of the medicine is covered on the outside of the blank pill core to make the medicine containing micro pill, or the medicine powder, or the solid dispersion of the medicine or the cyclodextrin inclusion compound of the medicine is directly made into the medicine containing micro pill. The surface of the medicine containing micro pill is sprayed with slow-releasing coating solution to make a slow-releasing micro pill which is outwards covered with the expansion layer and is finally covered with the timing controlled releasing layer, and thus, the timing slow-releasing micro pill of the present invention is prepared. The formulation commonly starts to release the medicine by delaying for two to five hours, and subsequently and slowly releases a certain dose of the medicine, and provides a good choice for clinicians to treating diseases with physiological rhythmicity.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, it prepares timing slow-releasing micrpill based on chronopharmacology by feasible galenic pharmacy method, is used for the disease treatment of rhythmicity morbidity, and the release of medicine meets the physiological rhythm of human body.
Background technology
Development along with chronopharmacology, common slow releasing preparation can not satisfy the needs of clinical treatment, study according to chronopharmacology, the all free rhythm and pace of moving things of the therapeutical effect of medicine, toxicity and physiological disposition, the physical signs level of the outbreak of disease and human body also is the rhythmicity variation and (sees The American journal ofCardiology, 1988, Vol.62:635-637:Circulation, 1990, Vol.82:897-902; HearDisease, 1988, Vol.2:1234-1235).
U.S. Alza company in December, 1993 application the patent of releasing osmosis pump sheet when selecting, patent No. US5,252,338, releasing osmosis pump sheet (COER-Verapamil) became the division of day and night controlled release preparation of first listing when the verapamil hydrochloride that uses this patented technology to produce was selected, and what it adopted is the osmotic pump controlled-releasing chip technology.
At home, Kanghong Sci. ﹠ Tech. Industrial (Group) Co., Ltd., Chengdu has applied for " oral formulations of pulse release and preparation method " patent, patent publication No. CN 1488332A.Inst. of Dongyu Enterprise Group Co., Ltd., Shenyang has applied for " new oral timing and controlled release system " patent, patent publication No. CN1261533A.More than two patents all adopt multiple coatings to prepare different time lag granule technologies, discharge medicine with pulse mode.
The present invention adopts the slow-release micro-pill technology of preparing to prepare slow-release micro-pill, at the external packets expanding material of slow-release micro-pill, makes timing slow-releasing micrpill at the external packets timing and controlled release film of expanding material.Releasing mechanism is: after micropill is met water, moisture slowly sees through the timing and controlled release film and enters expanding layer, expanding layer material water-swellable, when the timing and controlled release film can not bear the pressure of expanding layer, the timing and controlled release layer breaks, slow-release micro-pill is exposed in the expanding layer corrosion, and slow-release micro-pill begins to discharge medicine according to the release rule of himself.Composition by adjusting the timing and controlled release film and thickness can the controlling slow release micropill release time, make its dispose procedure produce an interval that matches with physiological period, reach the effect that the division of day and night treats.
Summary of the invention
Purpose one of the present invention be the timing slow-releasing micrpill that has been to provide a kind of timing slow-releasing micrpill and application to make make select the time slow releasing capsule, slow releasing tablet when selecting.Timing slow-releasing micrpill comprises two kinds of basic structures, and basic structure 1 is made up of celphere, medicated layer, slow release layer, expanding layer, timing and controlled release layer; Basic structure 2 is made up of pastille nuclear, slow release layer, expanding layer and timing and controlled release layer.
Wherein, as one of scheme, described timing slow-releasing micrpill, its basic structure is made of celphere, medicine, slow release layer, expanding layer and timing and controlled release layer, count by weight percentage, medicine 2%～55%, celphere 0～50%, slow release layer 5%～40%, expanding layer 5%～30%, timing and controlled release layer 5%～35%, wherein
The component of celphere can be microcrystalline Cellulose, starch, sucrose, lactose, glucose, dextrin, phosphate, acetate, aminoacid, sodium chloride, potassium chloride, mannitol, sorbitol; Above material can use separately also and can be used.
Medicated layer is made up of the mixture of medicine or medicine and adjuvant or the solid dispersion of medicine or the Benexate Hydrochloride of medicine or the hydroxypropyl clathrate of medicine.The operable carrier of the solid dispersion of medicine comprises Polyethylene Glycol, Bo Luoshamu, polyvidone, carbamide, Eudragit resin, ethyl cellulose, acrylic resin.The hydroxypropyl clathrate of the Benexate Hydrochloride of medicine and medicine can adopt solvent method, the polishing preparation.
Slow release layer is made up of slow-release material, plasticizer and porogen, and slow-release material is selected from Eudragit series plastics, cellulose acetate, ethyl cellulose, tacryl element, acrylic resin, cellulose acetate titanate esters, hydroxypropyl emthylcellulose titanate esters; Plasticizer is selected from triethyl citrate, Methyl Benzene-o-dicarboxylate, dibutyl sebacate, diethyl phthalate, dibutyl phthalate; Porogen is selected from hydroxypropyl emthylcellulose, hydroxypropyl cellulose, Polyethylene Glycol, polyvidone, micropowder sodium chloride.
The expanding layer material is selected from hydroxypropyl emthylcellulose, hydroxypropyl cellulose, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, polyvidone, phosphate, acetate, can use separately, also can be used.
The timing and controlled release layer is made up of controlled-release material, plasticizer and porogen, and controlled-release material comprises coating materials such as Eudragit series acrylic resin, ethyl cellulose, methylcellulose, Cera Flava, Palmic acid tristearin; Plasticizer comprises triethyl citrate, dibutyl sebacate, diethyl phthalate, dibutyl phthalate.Porogen is selected from hydroxypropyl emthylcellulose, hydroxypropyl cellulose, Polyethylene Glycol, polyvidone, micropowder sodium chloride.
Treatment hypertension, angina pectoris, asthma, arthralgia, diabetes, the medicine of gastric ulcer is fit to make timing slow-releasing micrpill and preparation thereof, and these medicines are including, but not limited to verapamil hydrochloride, the sulphuric acid diltiazem, nitrendipine, nimodipine, nisoldipine, lacidipine, nicardipine, Amlodipine Besylate Tablet, amlodipine maleate, luxuriant and rich with fragrance Lip river Horizon, losartan, Irb, valsartan, Candesartan, telmisartan; Isosorbide acid, isosorbide mononitrate, nitroglycerin, aspirin, glipizide, gliquidone; Salbutamol sulfate, salmaterol, levodropropizine, dextromethorphan hydrobromide; Omeprazole, magnesium omeprazole, Omeprazole Sodium, lansoprazole, Tenatoprazole, Pan draws azoles sodium, famotidine, ranitidine.
One of the preferred technical solution of the present invention (being fit to the medicine of single dose less than 30mg) is as follows.
Medicine accounts for 4%～35% of prescription, and celphere accounts for 30%～50% of prescription, and the sustained release coating material accounts for 5%～20% of prescription, and expanding material accounts for 5%～25% of prescription, and the timing and controlled release coating material accounts for 5%～25% of prescription.
Another optimal technical scheme of the present invention (being fit to the medicine of single dose greater than 20mg) is as follows.
Medicine accounts for 30%～50% of prescription, and celphere accounts for 0～20% of prescription, and the sustained release coating material accounts for 8%～25% of prescription, and expanding material accounts for 5%～25% of prescription, and the timing and controlled release coating material accounts for 10%～30% of prescription.
The method of controlled release preparation when second purpose of the present invention provides above-mentioned the selecting of preparation may further comprise the steps:
The preparation of the timing slow-releasing micrpill of basic structure 1:
1, get the adjuvant of preparation celphere, mix homogeneously is crossed 100 mesh sieves, and mixing is with coating pan or centrifugal coating pelletizing machine or fluid bed system micropill.Taking-up, dry for standby.
2, get and make celphere and put in coating pan or centrifugal granulator machine or the fluid bed, spray into binding agent, add drug powder or the solid dispersion of medicine or the cyclodextrin clathrate of medicine, medicine is wrapped in the outside of celphere; Or with medicine dissolution in binding agent, be sprayed on the surface of celphere.Take out the micropill drying of having wrapped medicated layer, standby.
3, get slow-release material, plasticizer and porogen and dissolve, be mixed with the coating solution of debita spissitudo, the pastille micropill is put in coating pan or centrifugal coating granulator or the fluid bed, spray into coating solution and make slow-release micro-pill with appropriate solvent.
4, in the external packets expanding layer of slow-release micro-pill,, progressively add expanding material, or expanding material is dissolved in the binding agent, be sprayed on the surface of slow-release micro-pill at the surface of slow-release micro-pill spray binding agent, standby.
5, with the timing and controlled release material dissolves, add the dissolving of suitable plasticizer and porogen and make timing and controlled release layer coating solution, coating solution is sprayed on the outside of expanding layer, take out oven dry.
6, can selectively add bag light shield layer or color clothing layer or flavoring layer at micropill
The preparation of the timing slow-releasing micrpill of basic structure 2:
1, medicine is mixed with adjuvant, with coating pan or centrifugal coating pelletizing machine or fluid bed system micropill; Or make micropill, dry for standby with extruding spheronization.
2 slow-release materials, plasticizer and porogen dissolve with appropriate solvent, are mixed with the coating solution of debita spissitudo, and the pastille micropill is put in coating pan or centrifugal coating granulator or the fluid bed, spray into coating solution and make slow-release micro-pill.
3, at the surface of slow-release micro-pill spray binding agent, progressively add expanding material, or expanding material is dissolved in the binding agent, be sprayed on the surface of slow-release micro-pill, standby.
4, with the timing and controlled release material dissolves, add the dissolving of suitable plasticizer and porogen and make timing and controlled release layer coating solution, coating solution is sprayed on the outside of expanding layer, take out oven dry.
5, can be selectively add bag light shield layer or color clothing layer or flavoring layer the timing and controlled release micropill hard capsule of packing into is promptly got the timing and controlled release capsule at micropill.
The drug release determination method of preparation is referring to two appendix XD first methods of Chinese Pharmacopoeia version in 2000.
Description of drawings
The release profiles of accompanying drawing 1-verapamil hydrochloride timing slow-releasing micrpill
Slow releasing capsule release profiles when accompanying drawing 2-valsartan is selected
Slow releasing capsule release profiles when accompanying drawing 3-nifedipine is selected
The specific embodiment
Further describe the present invention by the following examples, should be noted that, these embodiment provide as the purpose of illustration, do not constitute limitation of the scope of the invention.
Embodiment 1The verapamil hydrochloride timing slow-releasing micrpill
Prescription of preparation and preparation method thereof is:
Prescription
Verapamil hydrochloride 120g
The blank pill heart (40 order) 20g
Eudragit?Rl?100 30g
Triethyl citrate 5.5g
Propylene glycol 2.5g
Hydroxypropyl emthylcellulose (HPMC) 36g
Propylene glycol 4g
Eudragit?RS100 30g
Triethyl citrate 5.5g
Propylene glycol 2.5g
Polyvidone 8g
Ethanol is an amount of
Preparation method:
Get the verapamil hydrochloride raw material and cross 100 mesh sieves, standby.Get polyvidone and add 80% ethanol 100ml dissolving, standby as binding agent; Eudragit Rl 100, triethyl citrate, propylene glycol add the 1000ml dissolve with ethanol, and be standby as sustained release coating liquid; It is standby as extender that hydroxypropyl emthylcellulose is crossed 100 mesh sieves: Eudragit (RS100) 30g, triethyl citrate 5.5g, propylene glycol 2.5g add ethanol 260ml dissolving, and be standby as outer controlled release coat liquid.
Get celphere, put in the coating pan or in the centrifugal coating granulator, spraying into 10% polyvidone ethanol liquid is binding agent, add verapamil hydrochloride medicated powder, make micropill.Spray into sustained release coating liquid, with micropill bag release membranes, coating finishes after drying 1 hour.Slow-release micro-pill is put in coating pan or the centrifugal granulator machine, sprays into 10% polyvidone ethanol liquid, adds hydroxypropyl emthylcellulose, the bag expanding layer.Spray into outer controlled release coat liquid bag controlled release layer.Coating finishes the back in 40 ℃ of dryings 12 hours, obtains timing slow-releasing micrpill.
With timing slow-releasing micrpill 1000 hard capsules slow releasing capsule when promptly getting verapamil hydrochloride and selecting of packing into.
Adopt two appendix XD first methods of Chinese Pharmacopoeia version in 2000 to measure the release of said preparation, record this preparation and postpone 4 hours release medicines, discharged fully in 20 hours.
Present embodiment is model drug with the verapamil hydrochloride, patient at night 10 take said preparation, medicine second day morning the 2-3 point begin to discharge, can well treat normal hypertension in early morning and the anginal outbreak of fine control patient that occurs of patient.
Embodiment 2The valsartan timing slow-releasing micrpill
Prescription of preparation and preparation method thereof is:
Prescription
Valsartan 80g
The blank pill heart (40 order) 12g
Eudragit?RS100 20g
Triethyl citrate 4g
Polyethylene glycol 6000 4g
Hydroxypropyl emthylcellulose (HPMC) 30g
Propylene glycol 3g
Eudragit?RS100 25g
Triethyl citrate 5g
Propylene glycol 1g
Polyvidone 8g
Ethanol is an amount of
Preparation method:
Get the valsartan raw material and cross 100 mesh sieves, standby.Get polyvidone and add 80% ethanol 100ml dissolving, standby as binding agent; Eudragit RS100, triethyl citrate, 650ml dissolve with ethanol, polyethylene glycol 6000 are dissolved in the 50ml water, add in the above-mentioned solution standby as sustained release coating liquid; It is standby as extender that hydroxypropyl emthylcellulose is crossed 100 mesh sieves; Eudragit (RSi00) 25g, triethyl citrate 5g, propylene glycol 1g add ethanol 200ml dissolving, and be standby as outer controlled release coat liquid.
Get celphere, put in the coating pan or in the centrifugal coating granulator, spraying into 10% polyvidone ethanol liquid is binding agent, add valsartan medicated powder, make micropill.Spray into sustained release coating liquid, with micropill bag release membranes, coating finishes after drying 1 hour.Slow-release micro-pill is put in coating pan or the centrifugal granulator machine, sprays into 10% polyvidone ethanol liquid, adds hydroxypropyl emthylcellulose, the bag expanding layer.Spray into encrust controlled release coat liquid bag controlled release layer.Coating finishes the back in 40 ℃ of dryings 12 hours, obtains timing slow-releasing micrpill.
With timing slow-releasing micrpill 1000 hard capsules slow releasing capsule when promptly getting valsartan and selecting of packing into.
Adopt two appendix XD first methods of Chinese Pharmacopoeia version in 2000 to measure the release of said preparation, record this preparation and postpone 4 hours release medicines, discharged fully in 18 hours.
Embodiment 3The nifedipine timing slow-releasing micrpill
Prescription of preparation and preparation method thereof is:
Prescription
Nifedipine 10g
Polyvidone k-30 30g
Ethanol 300ml
The blank pill heart (30～24 order) 110g
Ethyl cellulose 20g
Propylene glycol 5g
Polyethylene glycol 1500 5g
Hydroxypropyl emthylcellulose (HPMC) 20g
Propylene glycol 3g
Eudragit?RS100 25g
Triethyl citrate 5g
Propylene glycol 1g
Polyvidone 6g
Iron oxide red 3g
HPMC 6g
Distilled water 100ml
Ethanol is an amount of
Preparation method:
Get the nifedipine raw material and add ethanol 300ml dissolving, add polyvidone and dissolve standby; Ethyl cellulose, propylene glycol, polyethylene glycol 1500 add the 800ml dissolve with ethanol, and be standby as sustained release coating liquid; It is standby as extender that hydroxypropyl emthylcellulose is crossed 100 mesh sieves; Eudragit (RS100) 25g, triethyl citrate 5g, propylene glycol 1g add ethanol 200ml dissolving, and be standby as the timing and controlled release coating solution; HPMC is dissolved in the 100ml distilled water, adds iron oxide red and stirs standby as the light shield layer coating solution.
Get celphere, put in the coating pan or in the centrifugal coating granulator,, make the pastille micropill at micropill surface spray nifedipine and polyvidone ethanol liquid.Spray into sustained release coating liquid, with micropill bag release membranes, coating finishes after drying 1 hour.Slow-release micro-pill is put in coating pan or the centrifugal granulator machine, sprays into 10% polyvidone ethanol liquid, adds hydroxypropyl emthylcellulose, the bag expanding layer.Spray into encrust controlled release coat liquid bag controlled release layer, bag light shield layer, coating finish the back in 40 ℃ of dryings 12 hours, obtain nitre benzene timing slow-releasing micrpill.
With timing slow-releasing micrpill 1000 hard capsules slow releasing capsule when promptly getting nifedipine and selecting of packing into.
Adopt two appendix XD first methods of Chinese Pharmacopoeia version in 2000 to measure the release of said preparation, record this preparation and postpone 4 hours release medicines, discharged fully in 18 hours.
Above embodiment 1, embodiment 2, embodiment 3 release profiles see Figure of description for details.
Claims (2)
1. timing slow-releasing micrpill, its basic structure is made of celphere, medicine, slow release layer, expanding layer and timing and controlled release layer, counts by weight percentage medicine 2%～55%, celphere 0～50%, slow release layer 5%～40%, expanding layer 5%～30%, timing and controlled release layer 5%～35%, wherein, described slow release layer is made up of slow-release material, plasticizer and porogen, and described timing and controlled release layer is made up of controlled-release material, plasticizer and porogen, wherein:
The adjuvant of described celphere is selected from microcrystalline Cellulose, starch, sucrose, lactose, glucose, dextrin, aminoacid, sodium chloride, potassium chloride, mannitol, sorbitol or their mixture;
Described slow-release material is selected from Eudragit series plastics, cellulose acetate, ethyl cellulose, tacryl element, acrylic resin, cellulose acetate titanate esters, hydroxypropyl emthylcellulose titanate esters;
Described expanding layer material is selected from hydroxypropyl emthylcellulose, hydroxypropyl cellulose, microcrystalline Cellulose, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, polyvidone, phosphate, acetate or their mixture;
Described controlled-release material is selected from Eudragit series acrylic resin, ethyl cellulose, methylcellulose, Cera Flava, Palmic acid tristearin;
Described plasticizer is selected from triethyl citrate, Methyl Benzene-o-dicarboxylate, dibutyl sebacate, diethyl phthalate, dibutyl phthalate;
Described porogen is selected from hydroxypropyl emthylcellulose, hydroxypropyl cellulose, Polyethylene Glycol, polyvidone, micropowder sodium chloride.
2. timing slow-releasing micrpill according to claim 1, the outside of its basic structure can increase light shield layer or color clothing layer or flavoring layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100552031A CN100376230C (en) | 2005-03-15 | 2005-03-15 | Timing slow-releasing micrpill and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100552031A CN100376230C (en) | 2005-03-15 | 2005-03-15 | Timing slow-releasing micrpill and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1682696A CN1682696A (en) | 2005-10-19 |
| CN100376230C true CN100376230C (en) | 2008-03-26 |
Family
ID=35262318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100552031A Active CN100376230C (en) | 2005-03-15 | 2005-03-15 | Timing slow-releasing micrpill and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100376230C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100361660C (en) * | 2006-01-10 | 2008-01-16 | 中国药科大学 | Levofloxacin slow release micropill, its preparation method and uses |
| CN101310712B (en) * | 2007-05-23 | 2011-12-21 | 杭州民生药业有限公司 | Nifedipine controlled release preparation and preparation method thereof |
| CN102579384B (en) * | 2011-01-17 | 2015-09-02 | 杭州赛利药物研究所有限公司 | Allopurinol slow-release micro pill tablet and preparation method thereof |
| CN103536538B (en) * | 2013-10-23 | 2016-06-29 | 海南康芝药业股份有限公司 | A kind of expansive pellet of effective taste masking and preparation method thereof |
| CN109350605A (en) * | 2018-10-24 | 2019-02-19 | 中国药科大学 | A kind of epiphysin slowbreak piece and preparation method thereof |
| CN114344294B (en) * | 2021-12-14 | 2023-07-14 | 上海现代制药股份有限公司 | Telmisartan oral solid preparation with stable product performance and preparation method thereof |
| CN117084992B (en) * | 2023-10-19 | 2023-12-26 | 华润双鹤利民药业（济南）有限公司 | Nifedipine controlled release tablet preparation and preparation method thereof |
-
2005
- 2005-03-15 CN CNB2005100552031A patent/CN100376230C/en active Active
Non-Patent Citations (4)
| Title |
|---|
| 口服缓控释制剂技术发展的新动向. 张宁等.国外医学药学分册，第27卷第4期. 2000 * |
| 口服缓控释制剂研究概况. 张俊贞等.药学服务与研究，第3卷第2期. 2003 * |
| 口服脉冲和定时释药系统. 邹豪等.国外医学药学分册，第26卷第1期. 1999 * |
| 缓释与控释小丸的研究进展. 阳长明等.华西药学杂志，第16卷第2期. 2001 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1682696A (en) | 2005-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101528203B (en) | Combined preparation for the treatment of cardiovascular diseases based on chronotherapy theory | |
| US4957745A (en) | Pharmaceutical preparation | |
| CN103211779B (en) | Comprise alkalescence selectivity 5-hydroxy tryptamine 5-HT 3blocker and organic acid drug delivery system | |
| CA2277017C (en) | Rapidly releasing and taste-masking pharmaceutical dosage form | |
| CN101977593B (en) | Drug delivery systems comprising weakly basic drugs and organic acids | |
| CZ298694A3 (en) | Preparation containing morphine salt with controlled release | |
| NZ520706A (en) | Drug containing particles with one layer of enteric polymer and one of enteric polymer mixed with a water insoluable polymer | |
| JP2008525335A (en) | Solid release modified pharmaceutical dosage form for oral administration | |
| JPH0735328B2 (en) | Multiple-release formulation | |
| CA2494017A1 (en) | Delayed release anti-viral product, use and formulation thereof | |
| EP1235562B1 (en) | Chronotherapeutic diltiazem formulations and the administration thereof | |
| WO1998027967A1 (en) | Release-controlled coated tablets | |
| CN101249083A (en) | Compound extended release formulation containing amlodipine and metoprolol and preparation | |
| WO2019130749A1 (en) | Novel fine particle coating (drug-containing hollow particle and method for manufacturing same) | |
| CN100376230C (en) | Timing slow-releasing micrpill and its preparation | |
| JP3221891B2 (en) | Rotary granulation and taste-masking coating for the preparation of chewable pharmaceutical tablets | |
| CN101095681A (en) | Alfuzosin Hydrochloride permeating pump type controlled-release preparation and method for preparing the same | |
| CN104869985A (en) | Extended release compositions of an aminoalkyl nitrate | |
| CN101099762B (en) | Blood pressue lowering sustained-release preparation with chrysanthemum flower and pearl | |
| CN101269056B (en) | Metoprolol salt oral administration impulse pellet preparation | |
| CN100396282C (en) | Slow released doxazosin mesilate capsule and its prepn process | |
| RU2411035C2 (en) | Modified release 6-methyl-2-ethyl-hydroxypyridine succinate dosage form | |
| JP6236079B2 (en) | Novel time-release pharmaceutical composition containing three active ingredients | |
| WO2015196956A1 (en) | Metoprolol sustained-release composition and preparation method thereof | |
| CN101219118B (en) | Impulse released oral medication preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: 100083 Haidian District, Xueyuan Road, No. 30, A building, room No. 15, room, room 15 Patentee after: COSCI MED-TECH Co.,Ltd. Address before: 100080, Haidian District satellite building, No. 63, Zhichun Road, Beijing, room 1410, Beijing Patentee before: COSCI MED-TECH Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230323 Address after: 8639, Floor 6, Building 3, No. 3, Yongchang North Road, Daxing District, Beijing, 100176 Patentee after: Beijing Kexin Jurun Pharmaceutical Technology Co.,Ltd. Address before: 100083 room 15, 15 / F, block a, Tiangong building, 30 Xueyuan Road, Haidian District, Beijing Patentee before: COSCI MED-TECH Co.,Ltd. |