CN109662958A - A method of prevention or treatment animal epizoite biology - Google Patents
A method of prevention or treatment animal epizoite biology Download PDFInfo
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- CN109662958A CN109662958A CN201710950686.4A CN201710950686A CN109662958A CN 109662958 A CN109662958 A CN 109662958A CN 201710950686 A CN201710950686 A CN 201710950686A CN 109662958 A CN109662958 A CN 109662958A
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Emergency Medicine (AREA)
- Dermatology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention discloses a kind of method prevented or treat animal epizoite biology, especially it is to provide a kind of new method prevented or treat the epizoic flea of companion animals such as cat or dog, louse, tick worm and/or acarid or its worm's ovum, including putting on clothes to animal and/or worn appliance (such as necklace), it is characterised in that pasted on the clothes or utensil close to the one side of animal skin and/or coat and drive away and/or kill drug paste made of animal epizoite bioactive substance and auxiliary material having.The defects of is caused by drug degradation failure in necklace and can not carry out correct dose medication according to the weight of animals for contact poisoning, sunlight exposure existing for companion animals or people in use the present invention overcomes the method that existing load medicine necklace etc. kills pest device in vitro.
Description
Technical field
The present invention provide it is a kind of prevention or treatment animal epizoite biology method, be especially to provide it is a kind of prevent or control
Treat the new method of the epizoic flea of companion animals such as cat or dog, louse, tick worm and/or acarid or its worm's ovum.
Background technique
Animal especially companion animals, such as cat or dog are easy parasitic various jumps as the warm-blooded animal for having coat with it
The parasites such as flea, louse, tick worm or acarid not only influence cat or dog etc. with animal health and mood, but also are easy to propagate
Disease, prevention or treatment animal epizoite biology, are essential.
Prevention or treatment animal epizoite biology, it usually needs the medication of multidose duration could effectively.In vitro
Desinsection is one of prevention or treatment animal epizoite biology common method.In addition to external use drops (such as Fu Laien, big favour
Deng) treat outside the parasites such as the outer flea of animal body, louse, tick or mite, common there are also external insect-killing devices, such as item
Circle, ear tag or pendicle etc..
The external insect-killing device that uses both at home and abroad prevents or treats animal epizoite biology at present, and there are mainly two types of sides
Formula:
One is use plants essential oil for the external insect-killing device of main anthelmintic ingredient, by killing in vitro for plant fiber material
Worm device (such as necklace) infiltration or rich load plants essential oil class anthelmintic activity substance are easy to after animal wears by essential oil
The aromatic substance of volatilization plays expeling or kills the epizoites such as flea, louse biology.It is this external by armaticity smell
Kill helminth device, gradually volatilize and disperse with armaticity effective component, repelling and killing efficacy be difficult to the long period continue, thus shadow
Effect is rung, or needs to be replaced frequently new desinsection necklace, increases economic cost and burden.Also, companion animals are also difficult to connect
The aromatic odor volatilized generates wearable device and contradicts and unfriendly mood.
Another kind is that external insect-killing device, mainly thermoplasticity is made in high dose insecticide ingredient and inert support material
The external insect-killing device (such as necklace, ear tag or pendicle) of resin material (such as PVC) is posted outside animal body by that will have to kill
It is external that necklace etc. is made in the insecticide substance and thermoplastic resin matrix material of infested effect and other auxiliary materials or filler jointly
Insect-killing device, after animal wears, the external insect-killing device such as necklace, being capable of continuous and effective in the long period as sustained release drug storage warehouse.
It is currently used, such as have France's dimension gram (virbac) depulization necklace (primary insecticide ingredient is Amitraz), Bayer Bitterfeld GmbH
Bolfo insect-repellent collar (primary insecticide ingredient is arprocarb) etc..
The above-mentioned external insect-killing device of the second way continues although overcoming drug effect existing for the first external insect-killing device
The defects of time is short, aromatic volatile smell causes animal to contradict wearing, but the external insect-killing device of the second way, due to
Active insecticidal components by moving to surface competence exertion repelling and killing efficacy in resinous substrates, in order to maintain effect and it is lasting when
Between, the external insect-killing device such as prepared desinsection necklace needs to load pesticide active ingredient (such as arprocarb, double by high-content
Carbonamidine, pyrethrins etc.), and animal may have a behaviors such as necklace of licking usually, especially multiple animals together when lick mutually pair
The external insect-killing device such as the necklace just worn, so as to cause animal that drug poisoning disease occurs to insecticide ingredient in necklace
Shape increases animal pharmaceuticals poisoning risk；The companion animals such as cat, dog wear the external insect-killing devices such as this necklace, companion animals
Owner's contact, stroke or very intimate animal during, be also easy to touch necklace, be easy to contact the insecticide ingredient on necklace surface and
Poisoning or uncomfortable symptom may occur, also increase people's insecticide poisoning risk.
And above two external insect-killing device, in animal wears, in insecticidal materials active constituent exposure air, especially
When companion animals are movable outdoors, the external insect-killing device such as necklace of wearing, insecticidal materials active constituent is easy to be wiped free of, illumination
Degrade or drench with rain loss etc., influence to prevent or kill the pests effect such as flea, lice, tick, mite.These external insect expelling devices are (such as item
Circle etc.), it is generally indicated by after dismantling and just needed replacing new necklace to animal wears most 3 months, actually often wear not
It is just decreased obviously to 1 month effect, in order to keep effect, it usually needs more renew necklace, not only increases use cost, and
The used rich necklace for carrying insecticide medicine is also easy to cause environmental hazard etc..
These carry medicine necklaces etc. and kill pest device in vitro, and when use also can not press suitable medicine according to the weight size of animal
Agent amount is applied, and the medicament contg carried in medicine necklace is fixed, to the possible dosage superelevation of animal that weight is small, and to body
Great animal dosage is insufficient, thus because underdosage influences drug effect, or because dosage superelevation brings toxic side effect.
Summary of the invention
For killing various defects existing for pest device outside the animal body of the prior art, the present invention provide a kind of prevention or
The new method for treating animal epizoite biology.Technical solution of the present invention is as follows:
The present invention provides a kind of prevention or the methods for the treatment of animal epizoite biology, including put on clothes to animal
And/or worn appliance, it is characterised in that pasted close to the one side of animal skin and/or coat by having on the clothes or utensil
There is expeling and/or kills drug paste made of animal epizoite bioactive substance and auxiliary material.
Method described above, wherein the contact surface adhesion animal skin of the drug paste and animal skin and/or coat
And/or coat；Described drives away and/or kills drug paste made of animal epizoite bioactive substance and auxiliary material having,
It can have suitable shape and/or construction, for example, the drug paste is smears, resin, plastic cement, solid gel or solid paste etc..
Method described above, wherein the drug paste, it is preferable that including adhesive-layer and drug storage layer.In use, adhesive-layer with
Paste and fix close to the one side of animal skin and/or coat or side on the utensil of clothes or wearing that animal is worn, drug storage layer with
Animal skin and/or coat are directly in contact, drug storage layer release to animal epizoite biology such as flea, lice, tick and/or mite
Or the pests such as its worm's ovum have the active insecticidal components for the bioactivity such as tagging, killing or killing, and directly kill these parasitism evils
Whole body distribution is carried out after worm, or the absorption of the sebum by being distributed on skin or coat, plays repelling and killing efficacy.
Method described above, the drug paste are optionally present back sheet between adhesive-layer and drug storage layer.It can store up
Medicine layer surface is directly coated with adhesive-layer, also can according to need, and has back sheet between adhesive-layer and drug storage layer, i.e. drug storage layer exists
Backing is laminated, another side of the adhesive-layer in back sheet.Back sheet can be suitable material in this field, such as polyester
It is film, plastic film, the fabric made of naturally occurring or synthetic fiber or combinations thereof (such as cotton paper or non-woven fabrics etc.), natural or synthetic
Leather or other common rubber belt materials.Adhesive-layer be applied to drug storage layer method or drug storage layer or adhesive-layer coating
To the method for back sheet, coating method commonly used in the art, such as spraying, dip-coating, extrusion or co-extrusion lamination skill can be
Art etc..
Method described above, wherein the drug paste optionally has each independently in viscose glue layer surface and drug storage layer surface
The protective layer for being easy to throw off.Protective layer can be release paper, anti-sticker, hard gauze or plastic film etc..In use, throwing off viscous
The protective layer of film surface pastes drug paste on the clothes that animal is worn or the utensil of wearing close to animal skin and/or coat
One side or side, paste it is fixed after, then throw off the protective layer of drug storage layer surface, make drug storage layer and animal skin and/or coat
Directly it is in contact.
As another embodiment, drug storage layer surface can also cover band mesh having openings therein, such as fabric mesh or modeling
Material screen net, control drug storage layer in active insecticidal components migration or rate of release, or protect animal skin and/or coat not by
Drug storage layer adhesion etc..
Method described above, wherein the adhesive-layer of the drug paste, can be viscose glue agent material commonly used in the art and
The adhesive-layer with suitable viscosity is made by conventional method in that art coating in suitable excipients.
Method described above, it is preferable that wherein animal epizoite biology is driven away and/or killed to the drug paste by having
Active material, thermoplastic resin matrix, the plasticizer being optionally present, the dissolution active material being optionally present solvent, optionally deposit
Stabilizer, be optionally present lubricant, be optionally present chelating agent, be optionally present migration promotor, be optionally present
Drug storage layer is made in colorant.
Preferably, it is calculated by the weight of drug storage layer, there is expeling and/or killing animal epizoite bioactive substance to account for
0.05~45% weight of drug storage layer, preferably 0.5~40% weight, 1~30% weight, or more preferably 5~25% weights
Amount is most preferably 5~15% weight.Wherein, described that there is expeling and/or kill animal epizoite bioactive substance, example
One of pesticidal agents of pyrethroid, phosphoric acid ester, organochlorine class or carbamates or two can be such as selected from
Kind or more；Preferably, the bioactive substance is low volatility and/or lipophilicity；It is highly preferred that it is described have drive away and/
Or it kills animal epizoite bioactive substance and is selected from Fipronil (fipronil), Amitraz (amitraz), S- methoprene
(S-methoprene), basudin (diazion), arprocarb (propoxur), metaflumizone (metaflumizone), than general
One or more of Sai Fen (pyriproxyfen) etc..
Preferably, it is calculated by the weight of drug storage layer, thermoplastic resin matrix accounts for 30~95% weight of drug storage layer, preferably
35~90% weight, 40~80% weight, or more preferably 40~70% weight.Wherein, the thermoplastic resin matrix
It is not particularly limited, such as can be selected from one or more of polyethylene, polyvinyl chloride, polyurethane etc.；Preferably, institute
The thermoplastic resin matrix stated is polyvinyl chloride (PVC).
The plasticizer, such as can be dioctyl phthalate, benzyl butyl phthalate, phthalic acid two
Butyl ester, citrate, phosphate, adipate ester, sebacate, polyol fatty acid ester etc.；Preferably, the plasticizer is selected from
Diethyl phthalate, dioctyl sebacate, dioctyl adipate, diisooctyl phthalate, citric acid acetyl three
Butyl ester, triethyl citrate, acetyl triethyl citrate, glyceryl triacetate, triphenyl phosphate, diethylene glycol monoethyl ether, phosphoric acid
Front three phenyl ester, diisooctyl adipate, phosphoric acid -2- ethylhexyl diphenyl ester, di (2-ethylhexyl) phthalate, phthalic acid
One of di-n-butyl ester, phthalic acid benzyl butyl ester, caprylic capric propylene glycol ester, three acid esters of Caprylic Capric etc. or
Person is two or more.Plasticizer consumption, those skilled in the art can use suitable dosage as needed, such as by drug storage layer
Weight calculates, and plasticizer is 0%~30% weight, preferably 0%~20% weight.
The solvent of the dissolution active material, such as can be amide solvent etc., it is preferable that the solvent is diethyl
Base toluamide, dimethyl acetamide, 2-Pyrrolidone, N-Methyl pyrrolidone etc..Solvent usage, those skilled in the art's root
According to needing to calculate using suitable dosage, such as by the weight of drug storage layer, solvent usage is 0%~50% weight, preferably
For 5%~20% weight.
Other conventional ingredients, such as stabilizer (such as epoxidised soybean oil), lubrication can also be contained in the drug paste
Agent (such as stearate, low molecular weight polyethylene), chelating agent (such as three nonyl phosphite esters), migration promotor (such as pepper
Base butyl ether etc.), colorant (such as titanium dioxide) etc., these ingredients, usual those skilled in the art can according to need progress
Addition, suitable species and suitable amounts etc. and known in the art, those skilled in the art can according to need choosing
With suitable auxiliary material and suitable dosage.
Adhesive-layer in the drug paste can use adhesive commonly used in the art, such as can be acryl glue
Or pressure sensitive adhesive, silica gel, Malaysia glue, acrylic acid coatings, water emulsion, solvent adhesive, water-base cement, heat-sensitive glue, oily gum, hot melt adhesive or
Auxiliary material is commonly used in composite glue etc., with adhesive-layer in this field, being made by appropriate method has suitable viscosity and peel strength
Adhesive-layer, belong to the ordinary skill in the art.
Method described above, wherein the utensil to animal wears is necklace, ear tag, pendicle etc.；Preferably, the utensil
For necklace, such as the neck circle etc. that cat or dog are worn.
Method described above, wherein the animal, for example, companion animals；Preferably, the companion animals be cat or
Dog.
Present invention method described above, wherein the ectoparasite biology of the animal body be flea, tick, mite and/or lice and it
Worm's ovum, larva and/or excreta etc..
Above-mentioned method, drug paste therein can manufacture as follows: while heating while admix under, will have expeling with/
Or kill animal epizoite bioactive substance and thermoplastic resin matrix and the auxiliary material of other optional additions is mixed
With, acquired homogeneous admixture is cooled and shaped and drug storage layer is made by molding, extruding or coating, or by molding, squeezing,
Co-extrusion pressure is applied on back sheet, and is cooled and shaped and drug storage layer is made, and then in the one side of drug storage layer obtained or is made
Drug storage layer back sheet another side on, be coated with the adhesive-layer of suitable viscosity, finally in the adhesive-layer of drug paste obtained and
Optionally it is bonded the protective layers such as release paper or antiadhesion barrier each independently on the outer surface of drug storage layer to obtain the final product.
Prevention or treatment animal epizoite in vitro insect-killing device (such as necklace, ear tag or pendicle with prior art
Deng) compare, prevention of the invention or the new method for treating animal epizoite biology at least achieve following advantageous effects:
1, in use process, since drug paste is pasted and fixed on the clothes that animal is worn or leans on the utensil (such as necklace) of wearing
The one side of nearly animal skin and/or coat, avoids animal from licking and contacts drug paste, reduces due tos animal contacts load medicine necklace etc. because licking and causes
Insecticide poisoning risk；Meanwhile during companion animals contact with people or is very intimate, people will not touch drug paste, reduce contact desinsection
Poisoning risk caused by agent, therefore use is safer.
2, when animal is movable outdoors, drug paste avoids solar exposure, rainwater drenches or scrapes, and improves drug effect
Duration and product service life.
3, relative to the method for carrying the external expelling worm device such as medicine necklace, method of the invention can be according to the body of animal
Weight and drug paste carry pharmaceutical quantities, by animal body gravity treatment with or cut out the drug paste of suitable size or quantity and carry out correct dose use
Medicine, avoiding load medicine necklace etc. can not be according to the defect of the weight of animals correct dose medication.
4, can regularly, easily more Adhesive plaster with changable medicine, carry medicine necklace etc. relative to replacement, the method for the present invention can be easier
Ensure the stabilization of desinsection drug effect and continue, and use is more convenient, cost is cheaper.
5, it is used cooperatively with existing load medicine necklace, certain time is used carrying medicine necklace, after drug effect decline, in the use
One side on the necklace crossed close to animal skin and/or coat pastes fixed drug paste described above, with continue volatilization prevention or
Animal epizoite biological effect is treated, without replacing and throwing away used load medicine necklace, not only economy, but also
It is good for the environment.
6, current load medicine necklace, ear tag or pendicle etc., are limited to outside animal body using position, the method for the present invention, can be with
Fixed drug paste described above is pasted close to the one side of animal skin and/or coat on the clothes that animal is worn, thus in animal
External use location and range are more extensive, more convenient to use.
Specific embodiment
Following embodiment, only exemplary illustration and explanation the method for the present invention, present invention implementation are not limited to following examples,
It does not constitute a limitation the scope of the present invention.
Embodiment 1: Amitraz deinsectization drug paste
Drug storage layer forms (weight percent): Amitraz 5%, diethyltoluamide (DEET) 10%, adipic acid-di-n
Butyl ester 20%, caprylic capric propylene glycol ester 10%, epoxidised soybean oil 5%, titanium dioxide 1%, polyvinyl chloride (PVC) 54%.
Adhesive-layer forms (weight percent): butyl rubber 35%, natural rubber 25%, talcum powder 15%, terpene resin
6%, Petropols 10%, polyisobutene 6%, dibutyl ester 3%.
Preparation: Amitraz and DEET are mixed and heated and stir to get solution；By remaining constituent of the drug storages such as polyvinyl chloride resin layer
Matter mixes, and mixes in mixing machine, and solution made from Amitraz and DEET is added, and continues to be heated to mixing in mixing
Homogenous mass uniformly is obtained, then by homogenous mass at 140 DEG C in extrusion coated to non-woven fabrics base material, being made after cooling has
The PVC drug storage layer of back sheet.Adhesive-layer constituent is taken, is stirred, extrusion coated is compound on back sheet at 120 DEG C
The drug paste with adhesive-layer, back sheet and drug storage layer is obtained, finally on the surface of adhesive-layer and drug storage layer, is bonded release paper respectively
Protective layer is cut by size up to deinsectization drug paste.
Deinsectization drug paste obtained (wide 1cm × long 6cm, weight 1g/ patch) is taken, 3 drug pastes is taken, throws off release outside adhesive-layer
On the inside of the common cat neck circle without any insecticide ingredient (i.e. close to cat skin and/or the one side of coat), then paper is affixed on
The release paper outside drug storage layer is thrown off, has the kitten (weight about 1.2kg) of flea to put on necklace to external parasitism is visually observed,
1 week more Adhesive plaster with changable medicine 1 time, continuous 1 month, 100% as a result is reached to the repelling and killing efficacy of cat flea, louse, tick, mite, kitten coat
It is smooth, it is looked by naked eyes sight and is combed with flea, be showed no flea, louse, tick and/mite or its larva or worm's ovum.
Embodiment 2: arprocarb deinsectization drug paste
Drug storage layer forms (weight percent): arprocarb 8%, diethyltoluamide (DEET) 12%, adipic acid-di-n
Butyl ester 10%, caprylic capric propylene glycol ester 10%, epoxidised soybean oil 5%, stearic acid 1%, polyvinyl chloride (PVC) 54%.
Adhesive-layer forms (weight percent): butyl rubber 20%, natural rubber 30%, calcium carbonate 10%, talcum powder
15%, terpene resin 15%, Petropols 5%, polyisobutene 3%, dibutyl ester 2%.
Preparation: arprocarb and DEET are mixed and heated and stir to get solution；By remaining constituent of the drug storages such as polyvinyl chloride resin layer
Matter mixes, and mixes in mixing machine, and solution made from arprocarb and DEET is added, and continues to be heated to mixing in mixing
Homogenous mass uniformly is obtained, then homogenous mass is expressed on non-woven fabrics base material at 150 DEG C, being made after cooling has backing
The PVC drug storage layer of layer.Adhesive-layer constituent is taken, is stirred, extrusion coated is compound to obtain on back sheet at 120 DEG C
Drug paste with adhesive-layer, back sheet and drug storage layer is bonded release paper protection finally on the surface of adhesive-layer and drug storage layer respectively
Layer is cut by size up to deinsectization drug paste.
Deinsectization drug paste obtained is taken, drug paste (wide 5cm × long 6cm, weight 5g/ patch) is cut, takes 4 drug pastes, throw off adhesive-layer
The release paper on surface is affixed on the garment interior (i.e. close to the one side of dogskin skin and/or coat) that dog is worn, and throws off drug storage layer surface
Release paper, seeing to naked eyes parasitic outside physical examination has had the dog (weight about 3kg) of louse and worm's ovum to put on clothes；It takes again obtained
Deinsectization drug paste takes 1 drug paste (wide 1cm × long 30cm, weight 5g/ patch), throws off the release paper of viscose glue layer surface, be pasted on after cutting
On the inside of common dog neck circle without any insecticide ingredient (i.e. close to the one side of dogskin skin and/or coat), drug storage layer is thrown off
The release paper on surface puts on necklace to dog.It more changes one's clothes within 1 week and drug paste 1 time on necklace, continuous 1 month, the coat of dog was suitable
It is sliding, it is looked by naked eyes sight and is combed with dedicated comb, be showed no flea, louse, tick and/mite or its larva or worm's ovum, as the result is shown
100% is reached to the repelling and killing efficacy of dog flea, louse, tick and mite.
Claims (10)
1. a kind of method of prevention or treatment animal epizoite biology, including put on clothes to animal and/or worn appliance,
It is characterized in that on the clothes or utensil pasting close to the one side of animal skin and/or coat and is driven away and/or killed by having
Drug paste made of animal epizoite bioactive substance and auxiliary material.
2. according to the method described in claim 1, wherein the contact surface adhesion of the drug paste and animal skin and/or coat is dynamic
Object skin and/or coat；Preferably, the drug paste is smears, resin, plastic cement, solid gel or solid paste.
3. method according to claim 1 to 2, wherein the drug paste includes adhesive-layer and drug storage layer, in adhesive-layer and storage
Back sheet is optionally present between medicine layer.
4. method according to claim 1 to 3, wherein the drug paste is respectively independent in viscose glue layer surface and drug storage layer surface
Optionally there is the protective layer for being easy to throw off on ground.
5. method described in -4 according to claim 1, wherein animal epizoite is driven away and/or killed to the drug paste by having
Bioactive substance, the plasticizer being optionally present, the solvent for dissolving active material being optionally present, is appointed at thermoplastic resin matrix
Stabilizer existing for selecting, the chelating agent being optionally present, the migration promotor being optionally present, is optionally deposited the lubricant being optionally present
Colorant drug storage layer is made.
6. according to the method described in claim 5, wherein the thermoplastic resin matrix is selected from polyethylene, polyvinyl chloride, gathers
One or more of urethane etc.；Preferably, the thermoplastic resin matrix is polyvinyl chloride (PVC).
7. method described in -6 according to claim 1, wherein described have expeling and/or killing animal epizoite biology living
Property substance be selected from one of pesticidal agents of pyrethroid, phosphoric acid ester, organochlorine class or carbamates or two
Kind or more；Preferably, described that there is expeling and/or kill animal epizoite bioactive substance selected from Fipronil
(fipronil), Amitraz (amitraz), S- methoprene (S-methoprene), basudin (diazion), arprocarb
(propoxur), metaflumizone (metaflumizone), than one or both of Pu Saifen (pyriproxyfen) etc. with
On.
8. method described in -7 according to claim 1, wherein the utensil to animal wears is necklace, ear tag, pendicle etc.；It is preferred that
Ground, the utensil are necklace.
9. method described in -8 according to claim 1, wherein the animal is companion animals；Preferably, the companion animals are
Cat or dog.
10. method described in -8 according to claim 1, wherein the ectoparasite biology of the animal body be flea, tick, mite and/or lice or
Its worm's ovum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710950686.4A CN109662958A (en) | 2017-10-13 | 2017-10-13 | A method of prevention or treatment animal epizoite biology |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710950686.4A CN109662958A (en) | 2017-10-13 | 2017-10-13 | A method of prevention or treatment animal epizoite biology |
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| Publication Number | Publication Date |
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| CN109662958A true CN109662958A (en) | 2019-04-23 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710950686.4A Pending CN109662958A (en) | 2017-10-13 | 2017-10-13 | A method of prevention or treatment animal epizoite biology |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12161089B2 (en) | 2020-12-21 | 2024-12-10 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal collar comprising isoxazoline compounds |
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| WO2011030122A2 (en) * | 2009-09-09 | 2011-03-17 | Reckitt & Colman (Overseas) Limited | Insect repellent: project fabric shield |
| CN103858790A (en) * | 2014-03-11 | 2014-06-18 | 甘肃省疾病预防控制中心 | Insect-proofing neck ring device for dog and preparing method thereof |
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| US5071704A (en) * | 1990-06-13 | 1991-12-10 | Fischel Ghodsian Fariba | Device for controlled release of vapors and scents |
| CN1185717A (en) * | 1996-03-29 | 1998-06-24 | 梅瑞尔公司 | N-Phenylpyrazole-Based Tick Collars for Dogs and Cats against Fleas |
| WO2000040084A2 (en) * | 1999-01-08 | 2000-07-13 | Y-Tex Corporation | Pet medallion |
| WO2011030122A2 (en) * | 2009-09-09 | 2011-03-17 | Reckitt & Colman (Overseas) Limited | Insect repellent: project fabric shield |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US12161089B2 (en) | 2020-12-21 | 2024-12-10 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal collar comprising isoxazoline compounds |
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