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CN109602491A - Prostate laser ablation dual-wavelength high-power surgery apparatus - Google Patents

Prostate laser ablation dual-wavelength high-power surgery apparatus Download PDF

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Publication number
CN109602491A
CN109602491A CN201811556557.8A CN201811556557A CN109602491A CN 109602491 A CN109602491 A CN 109602491A CN 201811556557 A CN201811556557 A CN 201811556557A CN 109602491 A CN109602491 A CN 109602491A
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laser
optic
acousto
mirror
reflecting mirror
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CN109602491B (en
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金洋
穆力越
金讯波
吕文斌
张彦鑫
梁昊
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Weihai Weigao Laser Medical Equipment Co Ltd
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Weihai Weigao Laser Medical Equipment Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00505Urinary tract
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577Ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/2065Multiwave; Wavelength mixing, e.g. using four or more wavelengths

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Electromagnetism (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Laser Surgery Devices (AREA)

Abstract

The present invention relates to the solid visible light lasers of the acousto-optic Q modulation continuously pumped and semiconductor near-infrared laser combination therapy human body soft tissue field, prostate laser ablation dual-wavelength high-power surgery apparatus specifically in high power laser light prostatectomy field, it is characterized in that laser head includes the solid state laser of exportable green visible beam and the semiconductor laser of exportable near-infrared laser light beam, in the operation optical fiber that green laser beam and near-infrared light beam are 400-800 microns through Aspheric lenses coupler core diameter, containing at least two sound field direction, square crossing acousto-optic Q- is switched and at least one two frequency-doubling crystal of Laser-Nonlinear each other in the solid state laser, the Beam parameter product of the output optical fibre of the semiconductor laser is less than the Beam parameter product of operation optical fiber, it is good with safety, it is easy to operate to doctor The advantages such as skill requirement is low.

Description

Prostate laser ablation dual-wavelength high-power surgery apparatus
Technical field
The present invention relates to combined to control with the solid visible light lasers of the acousto-optic Q modulation continuously pumped and semiconductor near-infrared laser Human body soft tissue field is treated, the specifically prostate laser ablation in high power laser light prostatectomy field is grown tall with double wave Power surgery apparatus.
Background technique
Benign prostate hyperplasia (BPH) will lead to frequent micturition, urodynia and the retention of urine.Before per urethra surgery electroblation obstruction Column glandular tissue is always " goldstandard " of Urology Surgery treatment BPH.Although it is a kind of micro- that per urethra, which does prostate excision (TURP), Surgical operation is created, but more mainly due to blood loss, and can be with significant complication.Laser technology is to this common blood loss problem Solution a kind of feasible therapeutic scheme is provided.In many years in past, Urology Surgery doctor and laser work person's use is not of the same race The laser treatment BPH of class, to find a kind of or better healing method similar with TURP therapeutic effect.Lasar prostate excision Effect, directly depend on factors, including optical maser wavelength, power, duration and surgical technic.
The Nd:YAG laser of near-infrared laser wavelength 1064nm begins to increase for prostate in phase early 1990s The treatment of raw disease.1064nm near-infrared laser is mainly absorbed by cell protein.Since absorptivity is not high, near-infrared laser Penetrate into tissue about 7mm or so.Because the area of impacted tissue is comparatively larger, heating is carried out slow, Consequent be the tissue being irradiated with a laser and its around have solidification phenomenon, can laser evaporation hyperplasia disease prostata tissue Effect is not obvious.Nd:YAG laser photocoagulation prostatectomy, to due to BPH(benign prostate hyperplasia) caused by bladder Outlet obstruction is a kind of effective treatment method, its effect can be beautiful compared with the effect that prostate transurethral prostate resection removes.It It unlike TURP, hardly bleeds in Nd:YAG laser surgery procedures, and there is no flushing liquor absorbing phenomenon, thus Nd:YAG swashs The risk of light prostate removal surgery just greatly reduces.But unfortunately, with the patient of Nd:YAG Lasar prostate excision art, It is often subject to the dysuria of several weeks.
The Tm:YAG Thulium lasers energy that wavelength is 2140nm high power (60-150W) Ho:YAG Bladder stone and wavelength is 2 microns It is effectively only absorbed by the water, the effect for removing tissue is better than with Nd:YAG laser.Ho:YAG laser and Tm:YAG Thulium lasers forefront Gland resection operation is also a kind of process of transurethral resection.Organize depth of penetration shallow, but it is poor to stop blooding.To Bladder stone prostate excision Art, cutting tissue effect is very strong, and tissue coagulation and hemostatic function are poor, and operation skill is difficult to grasp.Ho:YAG Bladder stone or Tm: The YAG Thulium lasers prostate removal surgery operating time is more longer than the time of the transurethral resection of standard, sometimes with concurrent Disease, hospital stays are up to a few days.
A kind of frequency multiplication Nd:YAG laser of United States Patent (USP) (patent No. US6,554,824) had both been generally termed swashing for KTP Light cuts off Benign Prostatic Hyperplasia Tissuess.Hemoglobin has very strong absorption (to absorb and be the green laser of 532nm wavelength Number > 200cm-1), but water is almost transparent to green light.When the green laser of high power KTP is by fiber optic conduction and by urethra photograph When on prostate, hemoglobin makes the prostata tissue for having about only 1 ~ 2mm thickness absorb almost institute the strong absorptivity of green laser Some laser energies make the temperature of there rise to 300 DEG C or more quickly.Moisture content in high temperature evaporation cell then evaporates Prostata tissue.Since green laser absorption layer is shallow, corresponding solidification layer is also just shallow, thus anastalsis is just without near-infrared laser The anastalsis of the Nd:YAG laser of wavelength 1064nm is good.In order to obtain the good surgical effect of not bleeding, Mai Lai Objective (Malek) et al., which once publishes an article, to be pointed out, in two patients after with KTP laser evaporation prostata tissue, uses 1064nm Nd:YAG laser stops blooding.In order to reach higher green laser absorption rate, United States Patent (USP) 6,554,824 emphasizes that laser must be with huge Burst mode operation, pulse width will be between 0.1 and 500 milliseconds, and pulse frequency is between 1 and 500Hz.
Chinese patent (101015474 B of CN) is described to be used for using the green laser of high power LBO of semiconductor laser pumping The method and instrument of soft tissue vaporization excision.The patented invention is designed using the laser of high-order transverse mode, so that intracavity beam exists 5 times of beam diameter when diameter at solid state gain medium is at least TEMoo mould, and the laser transverse mode quantity generated is more than 10. The advantages of invention is that photoelectric efficiency and overall efficiency that green laser generates are relatively high, but the disadvantage is that this method and instrument can only Generate the laser of a wavelength, the i.e. green laser of only 532nm.Green laser is visible light, and anastalsis during surgery is not so good as Near-infrared laser is good.When intraoperative hemorrhage is larger, it has to stop Green laser surgery, the mode for changing traditional cutting is stopped blooding, or is made Stopped blooding with near-infrared laser.
Chinese invention patent CN102695468B is described to be performed the operation by way of melting and solidifying using infrared laser and be controlled Treat hyperplasia of prostate.The patented invention utilizes semiconductor laser, especially infrared laser, i.e. 900- in the patent The laser of 2000nm.With regard to the action principle of laser and soft tissue it is known that the vaporization excision effect of infrared laser is weak, but solidify Pretty good with the effect of ablation, haemostatic effect is good, almost without bleeding in art.But the disadvantage is that this laser increases for prostate It is found after raw clinical operation, causes postoperative irritation obvious because solidification layer is too thick, several weeks also occur that solidification layer is de- Fall the complication of blocking urethra.
When the temperature in cell tissue is increased beyond 60 DEG C, the denaturation referred to as " solidified " work will occur for protein With.When temperature is more than 100 DEG C, the moisture content of cell interior begins to boil and evaporate, and cell tissue and moisture content are all evaporated. With laser irradiation and evaporate as a result, cell tissue broken into pieces by the water of laser and boiling after, removed from basic stitch. For prostate laser ablation art, near-infrared laser of the wavelength between 800-1100nm is to freezing action and bloodless operation It is undoubtedly good, and the green laser of 532nm is effectively to laser evaporation and removing proof.
The advantage that near-infrared laser of the wavelength between 800-1100nm and wavelength are both visible lasers of 532nm is come Carry out prostate laser ablation, it is necessary to provide a kind of mode and instrument to utilize the laser of both wavelength can simultaneously Prostate is efficiently evaporated, can also avoid possible bleeding in operation to the maximum extent.
Chinese utility model patent CN201108497Y describes a kind of dual wavelength laser therapy prostate gland hyperplasy equipment.Though The right patent indicates green laser and infrared laser economic cooperation beam can be used after form dual-wavelength laser, and couple as carried out in optical fiber Hyperplasia of prostate operation, but the patent does not do any laser cavity design to green laser and infrared laser, laser parameter designs, Or possible designs, the patent do not have the exploitativeness in laser engineering.
Chinese invention patent application Publication Specification CN1891173A describes the green laser of 532nm using Nd:YAG frequency multiplication The green laser of 532nm of the dual-wavelength laser surgery apparatus and Nd:YAG frequency multiplication of beam is closed with the 1064nm of its fundamental wave and semiconductor swashs The dual-wavelength laser surgery apparatus of combiner.It may be from change 532nm frequency multiplication in view of the fundamental wave Nd:YAG laser in the specification to swash Optical cavity design, is allowed to export 1064nm near-infrared wavelength or an additional Nd:YAG laser simultaneously, dual-wavelength laser design Disadvantage is obvious.
First, this patent application publication specification is in green light delivery efficiency far below the present invention, the dual wavelength of announcement Respectively 532nm laser and 1064nm laser, the output of 1064nm laser are to extract 1064nm fundamental wave from frequency multiplication 532nm laser to be To reduce endovenous laser power density, to sacrifice shg efficiency, lead to the reduction of 532nm laser output power;Second, safety With the practicability is poor, this patent 1064nm export when, 532nm is also exported simultaneously, can not be to 1064nm and 532nm laser according to hand Art demand is independently arranged respective laser power.Due to sharing laser cavity, a wavelength laser breaks down, another wavelength It will appear failure;Third, exploitativeness aspect is not as good as the present invention, if the additional Nd:YAG laser of this patent can make complete machine It is extremely complex, it is with high costs there is no practicability.It can also be with although describing near-infrared laser in the patent application publication specification It is semiconductor laser, but there is no do specific regulation to the characteristic of semiconductor laser and have to how to be done using semiconductor laser The design of body.Optical characteristics in view of semiconductor laser is the fast axle and slow axis divergence feature difference of its light beam, and in the present invention The optical characteristics of Solid State Laser is axially symmetric.Specific regulation is not being done to the characteristic of semiconductor laser and to how making It is made of semiconductor laser in the case where specifically designing, whether application for a patent for invention Publication Specification CN1891173A or reality Solid State Laser light beam and semiconductor laser beam can not be all coupled by the content announced with new patent CN201108497Y Enter simple optical fiber.How the wave-length coverage of the nearest infrared semiconductor laser of the present invention, laser characteristics and output power swash green Light and near-infrared semiconductor laser are coupled to operation and have done science and exploitativeness design with optical fiber.
Invention per urethra did prostate removal surgery (TURP) since 50 years, and TURP has become to benign prostatic hyperplasis (BPH) the most widely used operation therapy.Because patient may lost a part of blood, prostate in the course of surgery The heat damage depth of tissue is difficult to control, and flushing liquor is also a series of not from the opening of the vein blood vessel of damage inflow blood vessel etc. Sharp factor, TURP is always with several complication.In addition, the patient for doing BPH operation is mostly elderly population, most patient There is the medical history of grave illness more than once, this adds increased the risks of operation.Although very being flowed as current goldstandard TURP Row, it is also quite attractive, but it is frequently accompanied by the complication such as urodynia, the urinary incontinence, impotence.Thus, medical field is actively being found always A kind of new, the few BHP operative treatment of complication goes to substitute traditional TURP.Lasar prostate excision operation, be it is a kind of most Good operative treatment.Wherein Nd:YAG Lasar prostate excision is introduced at first.Nd:YAG Lasar prostate excision hand The advantages of art is that hemostasis is splendid, but the disadvantage is that cell tissue peeling effect is poor, often there is the case where dysuria after operation.In previous generation It records the middle period nineties, Ho:YAG Bladder stone is used for prostatectomy.The clinical effectiveness and TURP of Bladder stone are suitable, but due to Solidification layer is shallow, hemostasis is poor, and operation skill is difficult to grasp, and the disease incidence of complication is not low.So before Ho:YAG Bladder stone Column adenectomy is not approved widely.The green laser of high power KTP or frequency multiplication Nd:YAG laser, are the later periods nineties Just it is used to treat BPH's.The green Lasar prostate excision art of KTP has than traditional TRUP and other Lasar prostate excisions operation Lot of superiority.The green laser of high power can effectively evaporate and remove prostata tissue, and operating time imitates short, solidification layer Shallowly, heat damage depth as shallow significantly reduces the disease incidence of postoperative complication.However in the course of surgery still has and to bleed Situation.Doctor has to switch over nearly TURP electrocision, or reduces green laser irradiation power density and reached with increasing coagulation result Anastalsis.It is not part nothing the matter with the green laser hemostasis of low power density from some documents delivered.
After 2010, the near-infrared semiconductor that wavelength is 980nm is released in uropoiesis circle by German Biolitec company and is swashed Light is used for operative treatment BPH.The laser surgery system possesses having the advantage that jointly for other semiconductor laser surgery systems, It is such as small in size, photoelectric efficiency is high, reliability is high.But the wavelength of 980nm semiconductor laser is close to the 1064nm of Nd:YAG, hand Art feature is also similar with the BPH of Nd:YAG operation, i.e. prostata tissue vaporization peeling effect is poor, often has after operation dysuric Situation.Advantage is also obvious, is exactly that haemostatic effect is good.
Summary of the invention
In order to solve deficiency in the prior art, it is good, easy to operate to doctor's technical ability that the present invention will provide a kind of safety It is required that low prostate laser ablation dual-wavelength high-power surgery apparatus.
In order to realize the above functions, the present invention will use following technical scheme:
A kind of prostate laser ablation dual-wavelength high-power surgery apparatus, it is characterised in that be equipped with laser head, double floor push and Laser head control unit, wherein the solid state laser of the laser head 10 including exportable green visible beam and exportable close The semiconductor laser of infrared laser light beam, green laser beam and near-infrared light beam are 400- through Aspheric lenses coupler core diameter In 800 microns of operation optical fiber, containing at least two sound field direction, square crossing acousto-optic Q- is switched each other in the solid state laser With at least one two frequency-doubling crystal of Laser-Nonlinear, such as lbo crystal, the length synthesis in laser beam axis direction is at least 18mm;The semiconductor laser includes output optical fibre and fiber coupling module, the light beam ginseng of semiconductor laser output optical fibre Number product is less than the Beam parameter product of operation optical fiber;The laser head control unit includes temperature controller, Q- switch driving Device, first laser driver and second laser driver, two frequency-doubling crystal of Laser-Nonlinear are quickly heated by temperature controller Or freeze accurately to control the temperature of two frequency-doubling crystal of Laser-Nonlinear, so that laser stablized the time within 10 seconds;Its temperature For degree control precision within 0.1 degree Celsius, the reaction time makes laser stablize the time within 10 seconds within 0.1 second; If two frequency-doubling crystal of Laser-Nonlinear is lbo crystal, the lbo crystal is by way of conductor temperature controller (TEC) Quickly to heat or freeze and accurately to control the temperature of LBO, Q-switch driver is connected with Q-switch respectively by electric wire, is driven Q-switch work, to reach higher laser output power, first laser driver passes through the pumping source of electric wire and solid state laser It is connected, second laser driver, which is connect by electric wire with the fiber coupling module that semiconductor laser exports, to be connected;It is described Double floor push, foot-operated one and foot-operated two including controlling the output of green laser or the output of near-infrared laser respectively, when stepping on Foot-operated information passes through cable transmission to control system, and control system starts green laser and exports for the moment, unclamps foot-operated a period of time, information By cable transmission to control system, when stepping on foot-operated two, information passes through cable transmission to control system, control system starting Near-infrared output, when unclamping foot-operated two, information is controlled respectively by cable transmission to control system, foot-operated two step on and unclamp The output and closing of near-infrared laser, when not being operated there are two foot pedal for one, the driving current of corresponding laser is dropped Down to below its laser output threshold value.
The laser cavity of solid state laser of the present invention is U-shaped structure, and the solid state laser includes front cavity mirror, the first acousto-optic Q-switch, the second acousto-optic Q-switching, pumping source, the first reflecting mirror, the second reflecting mirror, frequency-doubling crystal, Effect of Back-Cavity Mirror, third reflecting mirror, Collector lens, semiconductor refrigerating heating device, wherein be coated with the height to 1064nm on the front cavity mirror, the first reflecting mirror respectively Anti- film, the second reflecting mirror are coated with the high-reflecting film to 1064nm and the anti-reflection film to 532nm on one side, and another side is coated with to 532nm's Anti-reflection film, Effect of Back-Cavity Mirror are coated with the high-reflecting film of 1064nm and 532nm, and third reflecting mirror is coated with the anti-reflection film to 532nm on one side, another Face is coated with the high-reflecting film of 980nm and the anti-reflection film of 532nm;The two-sided anti-reflection film for being coated with 980nm and 532nm of collector lens, pumping Source generation wavelength is in the laser of 1064nm, and 1064nm laser is between front cavity mirror, the first reflecting mirror, the second reflecting mirror and Effect of Back-Cavity Mirror Concussion, the output power of 1064nm laser is improved by the first acousto-optic Q-switching and the second acousto-optic Q-switching, and frequency-doubling crystal will The laser of 1064nm is converted to the intracavitary green laser of 532nm, and semiconductor refrigerating heating device makes frequency-doubling crystal by adjusting temperature Work reaches maximum shg efficiency, intracavitary green laser is transmitted by the 532nm anti-reflection film of the second reflecting mirror in optimal path The outer green light of chamber is formed, transmits to form green light optical path using the 532nm anti-reflection film of third mirror surface.
The laser cavity of solid state laser of the present invention is U-shaped structure, and the solid state laser includes front cavity mirror, the first acousto-optic Q-switch, the second acousto-optic Q-switching, pumping source, the second reflecting mirror, frequency-doubling crystal, Effect of Back-Cavity Mirror, third reflecting mirror, collector lens, half Conductor cooling and heating device, wherein the front cavity mirror, the second reflecting mirror are coated on one side to the high-reflecting film of 1064nm and to 532nm Anti-reflection film, another side is coated with the anti-reflection film to 532nm, and Effect of Back-Cavity Mirror is coated with the high-reflecting film of 1064nm and 532nm, third reflecting mirror It is coated with the anti-reflection film to 532nm on one side, another side is coated with the high-reflecting film of 980nm and the anti-reflection film of 532nm;The two-sided plating of collector lens There are an anti-reflection film of 980nm and 532nm, pumping source generation wavelength is in the laser of 1064nm, and 1064nm laser is in front cavity mirror, second anti- It penetrates between mirror and Effect of Back-Cavity Mirror and shakes, the output work of 1064nm laser is improved by the first acousto-optic Q-switching and the second acousto-optic Q-switching The laser of 1064nm is converted to the intracavitary green laser of 532nm by rate, frequency-doubling crystal, and semiconductor refrigerating heating device is by adjusting temperature Degree makes frequency-doubling crystal work in optimal path, reaches maximum shg efficiency, and intracavitary green laser passes through the 532nm of the second reflecting mirror Anti-reflection film transmits to form the outer green light of chamber, transmits to form green light using the 532nm anti-reflection film of third mirror surface Optical path.
Front cavity mirror of the present invention, the first acousto-optic Q-switching, the second acousto-optic Q-switching, pumping source form the first lateral light paths, The laser that pumping source is issued is lateral into second be made of frequency-doubling crystal, Effect of Back-Cavity Mirror through the first reflecting mirror and the second reflecting mirror Optical path, the first acousto-optic Q-switching and the second acousto-optic Q-switching are between front cavity mirror and pumping source.
Front cavity mirror of the present invention, pumping source form the first lateral light paths, and the laser that pumping source is issued is through the first reflection Mirror, the first acousto-optic Q-switching, the second acousto-optic Q-switching and the second reflecting mirror enter the second lateral light by frequency-doubling crystal, Effect of Back-Cavity Mirror Road, the first acousto-optic Q-switching and the second acousto-optic Q-switching are between the first reflecting mirror and the second reflecting mirror, among laser cavity The beam diameter of position is thicker, therefore laser power density herein is also relatively low, by the first acousto-optic Q-switching and the second acousto-optic Q Switch is put in the middle position of entire Solid Laser Resonator, and the first acousto-optic Q-switching and the placement of the second acousto-optic Q-switching can be changed herein The shutdown efficiency of kind first acousto-optic Q-switching and the second acousto-optic Q-switching reduces the light leakage power of acousto-optic Q-switching when off, shortens Laser pulse width and the transfer efficiency for improving green laser.
The pumping source of the present invention includes that a solid laser medium is swashing for ND:YAG, Nd:YLF or Nd:YVO4 Optical wand is equipped with no less than two diode-end-pumped laser bars in pumping source.
Near-infrared generator of the present invention includes 980nm fiber coupling module, coupling module cooling fin, 980nm transmission Optical fiber and 980 laser aligners, 980nm fiber coupling module, which is semiconductor laser, passes through 980nm transmission fiber through overcoupling After output, by 980nm laser aligner output 980nm directional light, directional light with by third reflecting mirror reflection after with green light Optical path is overlapped, and converges light to form convergence light using collector lens, converges light coupled into optical fibres, exports laser.
Near-infrared generator of the present invention includes that open type 980nm laser and 980nm coupled lens, coupling module dissipate Backing, 980nm transmission fiber and 980 laser aligners, open type 980nm laser are launched scattering light, are coupled by 980nm After lens, the directional light of 980nm is formed, after the reflection of third reflecting mirror, is overlapped with green light optical path, the coupling after collector lens It is fine to close entering light.The near-infrared semiconductor laser is the laser of space output, and wavelength is between 800-1100nm.Semiconductor laser The laser of sending directly passes through one or row's aspherical mirror collimation, exports and imitates so as to avoid laser brought by fiber coupling The reduction of rate.The purpose of the design is to be further simplified the semiconductor laser structures, improves luminous efficiency.
Solid state laser of the present invention is by continuous semiconductor laser pump (ing).
Near-infrared semiconductor laser of the present invention for operation is continuous output or chopping way.
Laser head control unit of the present invention is additionally provided with cooling system, wherein cooling system be respectively pumping source and 980nm fiber coupling module provides heat dissipation, and temperature controller is connected by electric wire with semiconductor refrigerating heating device, control half The temperature of conductor cooling and heating device, first laser driver are connected by electric wire with pumping source, and semiconductor laser is driven Work, make pumping source generate 1064nm laser, Q-switch driver by electric wire respectively with the first acousto-optic Q-switching and the rising tone Light Q-switch is connected, and drives the first acousto-optic Q-switching and the work of the second acousto-optic Q-switching, reaches higher laser output power, the Dual-laser driver is connect by electric wire with 980nm fiber coupling module, driving 980nm fiber coupling module work output The laser of 980nm.
Cooling system of the present invention includes pumping source heat-sink unit and 980nm fiber coupling module heat-sink unit, described Pumping source heat-sink unit, cooling system are connected with pumping source, and the water route of cooling system is to the semiconductor laser in pumping source Heat dissipation is provided with ND:YAG laser medium stick, 980nm fiber coupling module is mounted on coupling module cooling fin, 980nm coupling The heat that module generates when working is transmitted on coupling radiating module, and the water route of cooling system is connected with coupling module cooling fin It connects, has taken away the heat in coupling module cooling fin, be reached for the purpose of 980nm fiber coupling module heat dissipation.
Frequency multiplication is completely used for into the green light of 532nm, delivery efficiency using the 1064nm laser that pump cavity exports in the present invention It is higher;Respective laser power is independently arranged to 1064nm and 532nm laser, twin wavelength laser output of the invention is respectively using not Same driver drives work, individual 532nm laser output or near-infrared laser output may be implemented, while in any laser When failure, the work of other laser is not influenced, and safety and practical performance greatly improve;In view of the optics of semiconductor laser Characteristic is that the fast axle of its light beam is different with slow axis divergence feature, and the optical characteristics of Solid State Laser is axially symmetric in the present invention 's.Specific regulation is not being done to the characteristic of semiconductor laser and to how doing the feelings specifically designed using semiconductor laser Under condition, Solid State Laser light beam and semiconductor laser beam can not be coupled into simple optical fiber.The present invention is partly led with regard to near-infrared How the wave-length coverage of volumetric laser, laser characteristics and output power by green laser and near-infrared semiconductor laser couple operation Science and exploitativeness design has been done with optical fiber.Further, since the outstanding vaporization cutting efficiency and near-infrared of green laser swashs The good tissue coagulation and haemostatic effect that light generates make the present invention improve the safety of operation, and to perform the operation to doctor's Skill requirement further decreases.In conclusion the present invention has many advantages, such as that delivery efficiency is high, highly-safe, exploitativeness is strong.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of the invention.
Fig. 2 is second of structural schematic diagram of laser head.
Fig. 3 is the third structural schematic diagram of laser head.
Fig. 4 is the 4th kind of structural schematic diagram of laser head.
Fig. 5 is the 5th kind of structural schematic diagram of laser head.
Fig. 6 is the continuous output and the copped wave way of output of near-infrared semiconductor laser in dual-wavelength laser.
Specific embodiment
The present invention will be further explained below with reference to the accompanying drawings:
Fig. 1 is the schematic diagram of dual-wavelength laser surgery systems, the system (100) be by the high power of 532nm by laser head (10), Control system (20), foot-operated (30) and optical fiber (115) composition.Wherein.Laser head 10 is opened including front cavity mirror 101, Q-switch 102, Q Close 103, pumping source 104, the first reflecting mirror 105, the second reflecting mirror 106, frequency-doubling crystal 107, semiconductor refrigerating heating device 108, Effect of Back-Cavity Mirror 109, third reflecting mirror 113, collector lens 114, output optical fibre fixed device 116,980nm fiber coupling module 110, coupling module cooling fin 117,980nm transmission fiber 111,980 laser aligners 112 composition.Front cavity mirror 101 is coated with pair The high-reflecting film of 1064nm.First reflecting mirror 105 is coated with the high-reflecting film to 1064nm.Second reflecting mirror 106 is coated with pair on one side The high-reflecting film of 1064nm and anti-reflection film to 532nm, another side are coated with the anti-reflection film to 532nm.Effect of Back-Cavity Mirror 109 is coated with 1064nm With the high-reflecting film of 532nm.Third reflecting mirror 113 is coated with the anti-reflection film to 532nm on one side, and another side is coated with the high-reflecting film of 980nm With the anti-reflection film of 532nm.The two-sided anti-reflection film for being coated with 980nm and 532nm of collector lens 114.
The way of output of 532nm laser are as follows: pumping source 104 includes a solid laser medium ND:YAG laser bar, pumping Multiple diode-end-pumped ND:YAG laser medium sticks in source 104.Laser of 104 generation wavelength of pumping source in 1064nm 121.1064nm laser 121 shakes between front cavity mirror 101, the first reflecting mirror 105, the second reflecting mirror 106 and Effect of Back-Cavity Mirror 109, The output power of 1064nm laser is improved by Q-switch 102 and 103.Frequency-doubling crystal 107 is converted to the laser 121 of 1064nm The intracavitary green laser 122 of 532nm, semiconductor refrigerating heating device 108 make the work of frequency-doubling crystal 107 most by adjusting temperature Good path reaches maximum shg efficiency.Intracavitary green laser 122 transmits shape by the 532nm anti-reflection film of the second reflecting mirror 106 The outer green light 123 of coelosis, transmits to form green light optical path 125 using the 532nm anti-reflection film on 113 surface of third reflecting mirror, then It converges light to form convergence light 126 by collector lens 114, converges light coupled into optical fibres 115, export laser 127.Its Middle optical fiber 115 is fixed on laser head 10 by optic fibre fixing device 116.
The way of output of 980nm laser are as follows: 980nm fiber coupling module 110 is that semiconductor laser passes through through overcoupling 980nm transmission fiber 111 exports, and the directional light 124 of 980nm is exported by 980nm laser aligner 112, is reflected by third Mirror 113 is overlapped after reflecting with green light optical path 125, converges light to form convergence light 126, convergence using collector lens 114 Light coupling entering light fibre 115 exports laser 127.
Control system 20 is by temperature controller 11, first laser driver 12, cooling system 13, Q-switch driver 14, Dual-laser driver 15 forms.Temperature controller 11 is connected by electric wire 16 with semiconductor refrigerating heating device 108, control half The temperature of conductor cooling and heating device 108.First laser driver 12 is connected by electric wire 16 with pumping source 104, driving half Conductor laser work, makes pumping source 104 generate the laser of 1064nm.Cooling system 13 is respectively pumping source 104 and 980nm light Fine coupling module 110 provides heat dissipation.The specific embodiment of heat dissipation is provided for pumping source 104 are as follows: cooling system 13 and pumping source 104 are connected, the water route of cooling system in pumping source 104 semiconductor laser and ND:YAG laser medium stick provide and dissipate Heat.The specific embodiment of heat dissipation is provided for 980nm fiber coupling module 110 are as follows: 980nm fiber coupling module 110 is mounted on On coupling module cooling fin 117, the heat that 980nm coupling module generates when working is transmitted on coupling radiating module 117.It is cooling The water route of system 13 is connected with coupling module cooling fin 117, has taken away the heat in coupling module cooling fin 117, has been reached for The purpose that 980nm fiber coupling module 110 radiates.Q-switch driver 14 is connected by electric wire 16 with Q-switch 102 and 103, It drives Q-switch 102 and 103 to work, reaches higher laser output power.Second laser driver 15 by electric wire 16 with 980nm fiber coupling module 110 connects, the laser of driving 980nm fiber coupling module work output 980nm.
Foot-operated 30 are made of foot-operated 1 and foot-operated 2 33, and two foot-operated controls respectively export green laser and near-infrared swashs Light.When stepping on foot-operated 1, information is transferred to control system 20 by cable 31, and control system starts green laser output, pine When opening foot-operated 1, information is transferred to control system 20 by cable 31, and control system closes green laser output.Similarly ride two 33 output and closing stepped on and unclamp control near-infrared laser respectively.
Fig. 2 is second of structural schematic diagram of dual-wavelength laser surgery systems laser head.The laser of the solid state laser Intracavitary Nd:YAG stick is directly adjacent to 1064nm laser mirror, and acousto-optic Q-switching is located at the middle position of entire Solid Laser Resonator. The purpose of the design is that the beam diameter in laser cavity middle position is thicker, therefore laser power density herein is also relatively low.? Acousto-optic Q-switching places the shutdown efficiency that can improve acousto-optic Q-switching herein, reduces the light leakage power of acousto-optic Q-switching when off, Shorten laser pulse width and improves the transfer efficiency of green laser.Second of structural representation Figure 150 and the Q that is distinguished as of scheme 10 are opened The position of pass 102 and 103 is changed.
Fig. 3 is the third structural schematic diagram of dual-wavelength laser surgery systems laser head.The third structural representation Figure 200 with The difference of scheme 10 is through open type 980nm laser 201 and 980nm coupled lens 202 instead of 980nm fiber coupling Module 110,980nm output optical fibre 111 and 980nm laser aligner 112.The output side 980nm of the third structural representation Figure 200 Formula are as follows: open type 980nm laser 201 launches scattering light 128, after 980nm coupled lens 202, forms the flat of 980nm Row light 124 is overlapped, the coupled into optical fibres after collector lens 114 after the reflection of third reflecting mirror 113 with green light optical path 125 115, the near-infrared semiconductor laser is the laser of space output, and wavelength is between 800-1100nm.Semiconductor laser issues Laser directly pass through one or row's aspherical mirror collimation, so as to avoid laser delivery efficiency brought by fiber coupling It reduces.The purpose of the design is to be further simplified the semiconductor laser structures, improves luminous efficiency.
In Fig. 4 and Fig. 5 of the invention, the laser cavity of the solid state laser is the laser cavity of a L-type.L-type laser cavity The advantages of be omitted 45 degree of reflecting mirrors of 1064nm in U-shaped cavity.Since the reflectivity of 45 degree of reflecting mirrors of 1064nm is eternal It can not be 100%, therefore the reflecting mirror will cause certain power loss.For a high power 1064nm laser, this is anti- Penetrating mirror will cause the laser power loss of about 3-5%.The purpose of design is the laser power in order to improve 1064nm laser, from And improve the laser power of 532nm.The near-infrared semiconductor laser can be free space output, be also possible to optical fiber coupling It is exported after conjunction.
Wherein, the difference of the 4th kind of structural schematic diagram 300 and the third structural representation Figure 200 are the first reflecting mirror 105 cancel, while front cavity mirror 101, the pumping source of Q-switch 102 and 103 104 in lateral light paths are changed to perpendicular direction, described solid The laser cavity of body laser is the laser cavity of a L-type.The advantages of L-type laser cavity, is omitted 45 of the 1064nm in U-shaped cavity Spend reflecting mirror.Since the reflectivity of 45 degree of reflecting mirrors of 1064nm never may be 100%, which will cause one Fixed power loss.For a high power 1064nm laser, which will cause the laser power loss of about 3-5%. The purpose of design is the laser power in order to improve 1064nm laser, to improve the laser power of 532nm.The near-infrared half Conductor Laser can be free space output, be also possible to export after fiber coupling.
The difference of 5th kind of structural schematic diagram 400 and the 4th kind of structural schematic diagram 300 is through 980nm fiber coupling mould Block 110,980nm transmission fiber 111,980nm collimator 112 couple saturating instead of open type 980nm laser 201 and 980nm Mirror 202.
Fig. 6 is the continuous output and the copped wave way of output of near-infrared semiconductor laser in dual-wavelength laser.Upper figure is copped wave Output, output of the output power with the variation discontinuity of time, output pulse width is adjustable output area 0.01ms--1s, output is frequently Rate range is that 1Hz--10kHz is adjustable.The following figure is continuous output, and output power does not change over time.
Frequency multiplication is completely used for into the green light of 532nm, delivery efficiency using the 1064nm laser that pump cavity exports in the present invention It is higher;Respective laser power is independently arranged to 1064nm and 532nm laser, twin wavelength laser output of the invention is respectively using not Same driver drives work, individual 532nm laser output or near-infrared laser output may be implemented, while in any laser When failure, the work of other laser is not influenced, and safety and practical performance greatly improve;In view of the optics of semiconductor laser Characteristic is that the fast axle of its light beam is different with slow axis divergence feature, and the optical characteristics of Solid State Laser is axially symmetric in the present invention 's.Specific regulation is not being done to the characteristic of semiconductor laser and to how doing the feelings specifically designed using semiconductor laser Under condition, Solid State Laser light beam and semiconductor laser beam can not be coupled into simple optical fiber.The present invention is partly led with regard to near-infrared How the wave-length coverage of volumetric laser, laser characteristics and output power by green laser and near-infrared semiconductor laser couple operation Science and exploitativeness design has been done with optical fiber.Further, since the outstanding vaporization cutting efficiency and near-infrared of green laser swashs The good tissue coagulation and haemostatic effect that light generates make the present invention improve the safety of operation, and to perform the operation to doctor's Skill requirement further decreases.In conclusion the present invention has many advantages, such as that delivery efficiency is high, highly-safe, exploitativeness is strong.

Claims (13)

1. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus, it is characterised in that be equipped with laser head, double floor push With laser head control unit, wherein the laser head includes the solid state laser of exportable green visible beam and exportable close The semiconductor laser of infrared laser light beam, green laser beam and near-infrared light beam are 400- through Aspheric lenses coupler core diameter In 800 microns of operation optical fiber, containing at least two sound field direction, square crossing acousto-optic Q- is switched each other in the solid state laser With at least one two frequency-doubling crystal of Laser-Nonlinear, the semiconductor laser includes output optical fibre and fiber coupling module, and half The Beam parameter product of conductor laser output optical fibre is less than the Beam parameter product of operation optical fiber;The laser head control unit Including temperature controller, Q- switch driver, first laser driver and second laser driver, two frequency multiplication of Laser-Nonlinear is brilliant Body is quickly heated by temperature controller or is freezed accurately to control the temperature of two frequency-doubling crystal of Laser-Nonlinear, Q-switch driving Device is connected with Q-switch respectively by electric wire, and first laser driver is connected by electric wire with the pumping source of solid state laser, Second laser driver, which is connect by electric wire with the fiber coupling module that semiconductor laser exports, to be connected;The both feet are stepped on out Foot-operated one and foot-operated two of the output including the output and near-infrared laser that control green laser respectively is closed, there are two ride at one When plate is not operated, the driving current of corresponding laser is reduced to its laser output threshold value or less.
2. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 1, it is characterised in that Gu The laser cavity of body laser be U-shaped structure, the solid state laser include front cavity mirror, the first acousto-optic Q-switching, the second acousto-optic Q-switching, Pumping source, the first reflecting mirror, the second reflecting mirror, frequency-doubling crystal, Effect of Back-Cavity Mirror, third reflecting mirror, collector lens and semiconductor refrigerating Heating device, wherein be coated with the high-reflecting film to 1064nm, the second reflecting mirror one side on the front cavity mirror, the first reflecting mirror respectively It is coated with the high-reflecting film to 1064nm and the anti-reflection film to 532nm, another side is coated with the anti-reflection film to 532nm, and Effect of Back-Cavity Mirror is coated with The high-reflecting film of 1064nm and 532nm, third reflecting mirror are coated with the anti-reflection film to 532nm on one side, and the height that another side is coated with 980nm is anti- The anti-reflection film of film and 532nm;The two-sided anti-reflection film for being coated with 980nm and 532nm of collector lens, pumping source generation wavelength is in 1064nm Laser, 1064nm laser shakes between front cavity mirror, the first reflecting mirror, the second reflecting mirror and Effect of Back-Cavity Mirror, passes through the first acousto-optic Q Switch and the second acousto-optic Q-switching improve the output power of 1064nm laser, and the laser of 1064nm is converted to 532nm by frequency-doubling crystal Intracavitary green laser, semiconductor refrigerating heating device makes frequency-doubling crystal work in optimal path, reaches maximum by adjusting temperature Shg efficiency, intracavitary green laser transmits to form the outer green light of chamber by the 532nm anti-reflection film of the second reflecting mirror, using third The 532nm anti-reflection film of mirror surface transmits to form green light optical path.
3. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 1, it is characterised in that Gu The laser cavity of body laser be U-shaped structure, the solid state laser include front cavity mirror, the first acousto-optic Q-switching, the second acousto-optic Q-switching, Pumping source, the second reflecting mirror, frequency-doubling crystal, Effect of Back-Cavity Mirror, third reflecting mirror, collector lens, semiconductor refrigerating heating device, In, front cavity mirror, the second reflecting mirror are coated with the high-reflecting film to 1064nm and the anti-reflection film to 532nm on one side, and another side is coated with pair The anti-reflection film of 532nm, Effect of Back-Cavity Mirror are coated with the high-reflecting film of 1064nm and 532nm, and third reflecting mirror is coated on one side to the anti-reflection of 532nm Film, another side are coated with the high-reflecting film of 980nm and the anti-reflection film of 532nm;Collector lens is two-sided to be coated with the anti-reflection of 980nm and 532nm Film, in the laser of 1064nm, 1064nm laser shakes pumping source generation wavelength between front cavity mirror, the second reflecting mirror and Effect of Back-Cavity Mirror It swings, improves the output power of 1064nm laser by the first acousto-optic Q-switching and the second acousto-optic Q-switching, frequency-doubling crystal is by 1064nm Laser be converted to the intracavitary green laser of 532nm, semiconductor refrigerating heating device makes frequency-doubling crystal work exist by adjusting temperature Optimal path, reaches maximum shg efficiency, and intracavitary green laser transmits to form chamber by the 532nm anti-reflection film of the second reflecting mirror Outer green light transmits to form green light optical path using the 532nm anti-reflection film of third mirror surface.
4. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 2 or 3, it is characterised in that Front cavity mirror, the first acousto-optic Q-switching, the second acousto-optic Q-switching, pumping source form the first lateral light paths, the laser that pumping source is issued Enter the second lateral light paths being made of frequency-doubling crystal, Effect of Back-Cavity Mirror, the first acousto-optic Q-switching through the first reflecting mirror and the second reflecting mirror And second acousto-optic Q-switching between front cavity mirror and pumping source.
5. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 2 or 3, it is characterised in that Front cavity mirror, pumping source form the first lateral light paths, and the laser that pumping source is issued is through the first reflecting mirror, the first acousto-optic Q-switching, the Two acousto-optic Q-switchings and the second reflecting mirror enter the second lateral light paths by frequency-doubling crystal, Effect of Back-Cavity Mirror, the first acousto-optic Q-switching and the Two acousto-optic Q-switchings are between the first reflecting mirror and the second reflecting mirror.
6. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 2 or 3, it is characterised in that The pumping source includes the laser bar that a solid laser medium is ND:YAG, Nd:YLF or Nd:YVO4, is equipped with not in pumping source Less than two diode-end-pumped laser bars.
7. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 1, it is characterised in that close Infrared emittance includes 980nm fiber coupling module, coupling module cooling fin, 980nm transmission fiber and 980 laser aligners, 980nm fiber coupling module is semiconductor laser after overcoupling is exported by 980nm transmission fiber, by 980nm laser quasi The directional light of straight device output 980nm, directional light is overlapped with after the reflection of third reflecting mirror with green light optical path, saturating using optically focused Mirror converges light to form convergence light, converges light coupled into optical fibres, exports laser.
8. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 1, it is characterised in that close Infrared emittance include open type 980nm laser and 980nm coupled lens, coupling module cooling fin, 980nm transmission fiber and 980 laser aligners, open type 980nm laser launches scattering light, after 980nm coupled lens, forms the flat of 980nm Row light is overlapped, the coupled into optical fibres after collector lens, the near-infrared after the reflection of third reflecting mirror with green light optical path Semiconductor laser is the laser of space output, and the wavelength laser that semiconductor laser issues between 800-1100nm directly passes through one A or row's aspherical mirror collimation, so as to avoid the reduction of laser delivery efficiency brought by fiber coupling.
9. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 1, it is characterised in that Gu Body laser is by continuous semiconductor laser pump (ing).
10. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 1, it is characterised in that use In the near-infrared semiconductor laser of operation be continuous output or chopping way.
11. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to Claims 2 or 3 or 7 or 8, It is characterized in that laser head control unit is additionally provided with cooling system, wherein cooling system is respectively pumping source and 980nm fiber coupling Module provides heat dissipation, and temperature controller is connected by electric wire with semiconductor refrigerating heating device, control semiconductor refrigerating heating The temperature of device, first laser driver are connected by electric wire with pumping source, and driving semiconductor laser work makes pumping source The laser of 1064nm is generated, Q-switch driver is connected with the first acousto-optic Q-switching and the second acousto-optic Q-switching respectively by electric wire, The first acousto-optic Q-switching and the second acousto-optic Q-switching is driven to work, second laser driver passes through electric wire and 980nm fiber coupling mould Block connection, the laser of driving 980nm fiber coupling module work output 980nm.
12. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 11, it is characterised in that Cooling system includes pumping source heat-sink unit and 980nm fiber coupling module heat-sink unit, and the pumping source heat-sink unit is cooling System is connected with pumping source, the water route of cooling system in pumping source semiconductor laser and ND:YAG laser medium stick mention For heat dissipation, 980nm fiber coupling module is mounted on coupling module cooling fin, the heat that 980nm coupling module generates when working It is transmitted on coupling radiating module, the water route of cooling system is connected with coupling module cooling fin.
13. a kind of prostate laser ablation dual-wavelength high-power surgery apparatus according to claim 11, it is characterised in that Two frequency-doubling crystal of Laser-Nonlinear is lbo crystal, and temperature control precision is within 0.1 degree Celsius, and the reaction time was at 0.1 second Within, so that laser stablized the time within 10 seconds.
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