CN109513119A - A kind of volume rotation intensity modulated radiation therapy plan collimator orientation optimization method - Google Patents
A kind of volume rotation intensity modulated radiation therapy plan collimator orientation optimization method Download PDFInfo
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- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
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Abstract
The invention discloses a kind of volumes to rotate intensity modulated radiation therapy plan collimator orientation optimization method, utilize patient-specific target structure information, three-dimensional reconstruction is carried out to target area, obtain the target area projected image under different frame angles, and specific aim optimization to carry out subsection optimization to full arc and is carried out to the collimator angle of every section of arc according to conformal index of the different collimator angles to target area, to realize the personalized dynamic collimation device orientation optimization method of volume rotation intensity modulated radiation therapy plan.This method is due to according to patient-specific target area information, can collimation device angle carry out dynamic optimization, artificial participation and plan quality are reduced to the degree of dependence of artificial experience, help to improve the efficiency and consistency of plan design, a plan for anisotropic optimization is designed for each patient, thus the improvement in brought dosimeter can be avoided some unnecessary tumor control rate declines and normal tissue injury, improve clinical radiotherapy curative effect.
Description
Technical field
The present invention relates to radiotherapy planning optimization methods more particularly to a kind of volume to rotate intensity modulated radiation therapy plan collimator angle
Optimization method.
Background technique
Radiotherapy is one of three big means for the treatment of cancer, and it is wild compared to fixed that volume rotates intensity-modulated radiation therapy technology
Adjusting has by force more preferably dosimetric characteristics and higher execution efficiency, therefore is widely used.Current volume rotates intensity modulated radiation therapy
Plan in optimization process, needs physics teacher that collimator angle is manually set or uses system default collimator angle, and whole
In a full arc, collimator angle immobilizes.On the one hand, the collimator angle artificially rule of thumb set does not consider patient
The specificity of target area geometry and geometric position, impersonal theory optimizes for each patient.On the other hand, in entire full arc
It the use of same collimator angle is not always optimal selection in range yet.Thus non-optimized plan will likely cause tumour
Control rate decline or normal tissue additional radiation.Therefore volume rotation adjusts strong plan collimator orientation optimization method to have important
Clinical meaning.But domestic and foreign current volume rotate intensity-modulated radiation therapy technology, used collimator angle be empirical value and
Manufacturer's recommended value does not carry out individuation optimization according to the individual difference of patient, and also there is no according to rack in entire full arc
The variation of angle is adjusted.Therefore, how to optimize to volume rotation intensity-modulated collimator angle is one urgently to be resolved
Problem.
Summary of the invention
The technical problem to be solved in the present invention is that for the defects in the prior art, a kind of volume rotation is provided adjusts and put by force
Treat plan collimator orientation optimization method.
The technical solution adopted by the present invention to solve the technical problems is:
The present invention provides a kind of volume rotation intensity modulated radiation therapy plan collimator orientation optimization method, and this method includes following step
It is rapid:
S1, the CT image and structure for obtaining patient construct three-dimensional target region shape；
S2, the target area for calculating three-dimensional target region shape progress two-dimensional projection under each different frame angles is simulated by software
Projection of shape；
S3, the conformal index in target area that different collimator angles are calculated according to projection of shape, and choose optimal solution and suboptimal solution
Corresponding collimator angle；
The optimal solution and the corresponding collimator angle of suboptimal solution that S4, basis obtain, draw collimator angle random frame angle
The variation tendency to rotate a circle, and determine the segmental radian range of every section of arc in variation tendency；
The segmental radian range that S5, basis obtain calculates the corresponding optimal collimator angle of every section of arc.
Further, step S1 of the invention method particularly includes:
The plan CT image of patient and structure are exported with DICOM file format from planning system, and import three-dimensional reconstruction
Software, according to the coordinate and structural information progress target area three-dimensional reconstruction in DICOM file.
Further, step S2 of the invention method particularly includes:
Rack virtual ray source is simulated by software to rotate a circle around target area geometric center, in a manner of Isocenter irradiation,
Computer rack ° rotation counterclockwise from 179 ° to 181 obtains 361 target areas projections at interval of the target area projection of shape under 1 ° altogether, and
Calculate the area of every target area projection.
Further, step S3 of the invention method particularly includes:
S31, according to obtained target area projection of shape, calculate collimator angle from 0 ° to 180 ° at interval of 1 °, multipage collimation
For device to the conformal index of target area, conformal index is the ratio of target area area and the area surrounded to also collimators vanes；
S32, ratio indicate that conformal index is more excellent closer to 1, select the conformal index of optimal solution and suboptimal solution corresponding
Collimator angle.
Further, step S4 of the invention method particularly includes:
S41, by obtained optimal solution and the corresponding collimator angle of suboptimal solution, ° drawn from 179 ° to 181 according to frame angle
Scatter plot processed and Trendline；
S42, according to the variation tendency and amplitude of collimator angle random frame angle in scatter plot, given threshold will collimate
The corresponding continuous rack angular divisions of device angle are one section of arc；Every section of arc length is all larger than 30 °, less than 360 °.
Further, step S5 of the invention method particularly includes:
S51, the target area projection of shape synthesis union projection to being obtained under all frame angles in every section of arc range；
S52, it is projected according to union, respectively with the multi-blade collimator of 0 ° to 180 ° collimator angle, conformal union is gone to project,
And calculate the area that multi-blade collimator surrounds；
S53, the area surrounded according to the multi-blade collimator of obtained each collimator angle calculate multi-blade collimator and surround
Residual area and carry out weighted sum summation, collimator angle corresponding to the optimal solution of summation be every section of arc optimal collimator
Angle.
Further, step S53 of the invention method particularly includes:
S531, institute's organic frame angle in section arc is subtracted with the area that the multi-blade collimator of every kind of obtained collimator angle surrounds
The target area projection obtained under degree, obtains the residual area Pi that the multi-blade collimator under each frame angle surrounds；
S532, weighted factor Wi relevant to the target area projected area of this frame angle to residual area Pi are weighted
Factor Q i is penetrated to leakage；
S533, is penetrated by factor Q i and is summed for the leakage under all frame angles in the section arc under every kind of collimator angle and is always leaked
Penetrate factor M；
S534, optimal solution is sought the M of all collimator angles, defining collimator angle corresponding to M is that this section of arc is optimal
Collimator angle.
Further, the threshold value setting in step S42 of the invention are as follows: 10%, 15%, 20%, 25% or 30%.
Further, the formula of weighted factor Wi is calculated in step S532 of the invention are as follows:
Wherein, Si is expressed as the area of the projection of the target area under each frame angle, and Sc is rack angle all in this section of arc
Spend the sum of the area of downrange projection.
Further, the calculation formula for penetrating factor Q i is leaked in step S532 of the invention are as follows:
Qi=Pi*Wi
Wherein, Pi is expressed as the residual area that multi-blade collimator surrounds under a kind of each frame angle of collimator angle,
Wi is weighted factor.
The beneficial effect comprise that: volume of the invention rotates intensity modulated radiation therapy plan collimator orientation optimization side
Method, (1) projection of shape in the case where the launched field direction of different frame angles is seen according to patient's three-dimensional target area are conformal based on optimal target area
Index carries out segment processing to full arc first, optimal collimator angle is chosen to every section of arc, final to realize full arc dynamic collimation
Device orientation optimization.The invention can carry out individuation optimization to patient care plan's parameter, be patient according to the opposite sex of patient target area
Strong plan is adjusted in the rotation of design personalized volume, avoids unnecessary tumor control rate decline and normal tissue injury.(2) relative to
Traditional is arranged collimator angle and full arc using the same collimator Angle Method based on experience, and the method for the present invention is due to using
Personalized full arc dynamic collimation device orientation optimization method, specificity is stronger, and artificial participation is low, and plan parameters are more excellent, patient
Radiotherapy is benefited higher.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples, in attached drawing:
Fig. 1 is the flow chart of the embodiment of the present invention；
Fig. 2 is the conformal target area mode of MLC of the embodiment of the present invention；
Fig. 3 is that the target area projection superposition generated in one section of arc of the embodiment of the present invention obtains union projection；
Fig. 4 be the embodiment of the present invention gone with a kind of MLC of collimator angle and conformal collection project；
Fig. 5 is the target that the area that the conformal angle MLC of the embodiment of the present invention is surrounded subtracts all frame angles in this section of arc
Area's projection.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that described herein, specific examples are only used to explain the present invention, not
For limiting the present invention.
As shown in Figure 1, the volume rotation intensity modulated radiation therapy plan collimator orientation optimization method of the embodiment of the present invention, including with
Lower step:
S1, basis sketch outline building patient target area three-dimensional geometrical structure；
S2, two projections of the target area under each frame angle are calculated；
S3, the conformal index in target area that different collimator angles are calculated according to the projection of shape that S2 is obtained, and choose it is optimal and
The corresponding collimator angle of suboptimal solution；
The variation tendency that S4, the collimator angle random frame obtained according to S3 rotate a circle determines the radian model of every section of arc
It encloses；
S5, the segmentation arc range obtained according to S4 calculate the optimal collimator angle of every section of arc.
It is specifically included in step S1:
S11, by patient target area and jeopardize organ structure information from planning system export, according to DICOM coordinate system carry out three
Target area is tieed up to rebuild；
It is specifically included in step S2:
S21, the target area 3D shape obtained according to S1, computer rack rotate (179 ° to 181 °) one week, every counterclockwise
The target area projection of shape under (BEV) is seen every 1 degree of obtained launched field direction；
It is specifically included in the step S3:
S31, each angle downrange projection of shape according to obtained in S2 calculate different collimator angles (0 ° to 180 °)
Under, the ratio of area and target area projected area that multi-blade collimator (MLC) surrounds, i.e., conformal index CI, the value of CI index is smaller,
It is then more excellent；
Collimator angle corresponding to S32, optimal and suboptimum the conformal index CI of selection is optimal under each frame angle
With suboptimum collimator angle；
It is specifically included in step S4:
S41, the optimal and suboptimum collimator angle for obtaining step S3 ° drafting scatter plot from 179 ° to 181 according to rack；
S42, according to the variation tendency and amplitude of collimator angle random frame angle in scatter plot, given threshold will collimate
Continuous rack angular divisions similar in device angle are one section of arc；Threshold value can be 30%, also can be set as needed, for example
10%, 15%, 20% or 25%.
It is specifically included in step S5:
The target area projection of shape synthesis union projection that S51 obtains S2 under all frame angles in every section of arc range, such as
Shown in Fig. 3；
S52, it is projected according to the union that S51 is obtained, goes conformal union to throw with the MLC of different collimator angles (0 to 180 degree)
Shadow as shown in Figure IV, and calculates the area that MLC is surrounded；
S53, the area surrounded according to the MLC of the obtained each collimator angle of S52 calculate the residual area that MLC is surrounded
And weighted sum summation is carried out, collimator angle corresponding to the optimal solution of summation is the optimal collimator angle of every section of arc.
It is specifically included in step S31:
The conformal mode of MLC blade described in S31 is using blade endpoint and target area boundary tangent method, specifically such as Fig. 2 institute
Show.For the multi-blade collimator MLC to the conformal index CI of target area, calculation formula is as follows:
Si is expressed as the area of the projection of the target area under each frame angle in above-mentioned formula (1), and Sm is expressed as MLC blade and encloses
The area in city.
It is specifically included in step S53:
Subtract in section arc what S2 under all frame angles was obtained with the area that the MLC of every kind of obtained collimator angle is surrounded
Target area projection, obtains the residual area Pi that the MLC under each frame angle is surrounded, as shown in figure 5, dark gray section is remaining face
Product Pi；
The obtained target area the S2 of the residual area Pi surrounded of MLC under obtained each frame angle and this frame angle is thrown
The relevant weighted factor Wi of shadow area, which is weighted to obtain to leak, penetrates factor Q i；
Weighted factor Wi.Calculation formula is as follows,
In above-mentioned formula (2), Si is expressed as the area of the projection of the target area under each frame angle, and Sc is to own in this section of arc
The projection of frame angle downrange the sum of area.
Factor Q i is penetrated in leakage.Calculation formula is as follows,
Qi=Pi*Wi (3)
In above-mentioned formula (3), Pi is expressed as the remaining face that MLC is surrounded under a kind of each frame angle of collimator angle
Product, Wi is weighted factor.
To the leakage under all frame angles in the section arc under every kind of collimator angle penetrate factor Q i sum to obtain total leakage penetrate because
Sub- M；
Optimal solution is asked to the M of all collimator angles, defining collimator angle corresponding to M is the optimal collimator of this section of arc
Angle.
In another specific embodiment of the invention:
Volume rotates intensity modulated radiation therapy plan collimator orientation optimization method, comprising the following steps:
Step S1: building patient's three-dimensional target region shape, i.e., by the plan CT image of patient and structure with DICOM file format
From planning system export, be then introduced into three-dimensional reconstruction software, according in DICOM file coordinate and structural information carry out target area three
Dimension is rebuild.
Step S2: calculating the downrange each frame angle BEV projection of shape, i.e. software simulation rack virtual ray source surrounds
Target area geometric center rotates a circle, with equal centers (SAD=100cm) radiation modality, computer rack from 179 ° to 181 ° counterclockwise
Rotation obtains 361 target area projections at interval of the target area projection of shape under 1 ° altogether, and calculates the area of every target area projection.
Step S3: calculating the more excellent collimator angle under each frame angle, i.e., every from 0 ° to 180 ° with collimator angle
1 ° of the MLC in interval goes to conformal every target area to project, and conformal mode is using blade endpoint and target area boundary tangent method, and totally 181 kinds
Conformal method, and the area that every kind of conformal method MLC blade surrounds is calculated, target area projected area is surrounded divided by MLC blade
Area obtains the conformal index in target area of every kind of collimator angle, and index indicates that conformal index is more excellent closer to 1.It selects optimal
More excellent collimator angle of the 2 collimator angles corresponding with the conformal index of suboptimum as each frame angle downrange.
Step S4: full arc is segmented according to more excellent collimator angular distribution, i.e., more excellent by 2 of each frame angle
Collimator angle degree drafting scatter plot and Trendline from 179 degree to 181 according to frame angle, according to collimator angle random frame angle
The distribution of degree, setting collimator angle change threshold value are 10%, 15%, 20% or 25%, and collimator angle is close
Continuous rack angular divisions are one section of arc, and every section of arc length need to be greater than 30 degree, less than 360 degree.
Step S5: the optimal collimator angle of every section of arc is calculated, i.e., using step S4 to the segmentation result of full arc, to every section
The target area projection that the S2 of all frame angles is obtained in arc is overlapped, and the union projection of every section of arc target area is calculated.With standard
MLC blade of the straight device angle from 0 ° to 180 ° at interval of 1 °, which goes to project target area union, to carry out conformal, and conformal mode uses MLC leaf
The method that piece midpoint is intersected with target area edge obtains 181 kinds of conformal angles altogether, and calculates every kind of conformal angle MLC blade and enclosed
At area.The MLC of the every kind of conformal angle area surrounded is subtracted into the target area that the S2 of all frame angles in this section of arc is obtained
Projection, obtains the residual area Pi that the MLC under each frame angle is surrounded.Residual area under each frame angle is added
Power, which handles to obtain to leak, penetrates factor Q, and weighted factor W is defined as the area Si of the projection of the target area under each frame angle and is this section of arc
The quotient of the sum of interior all areas of frame angle downrange projection Sc, as shown in formula (2).To the institute of every kind of collimator angle
Residual area leakage under organic frame angle, which penetrates factor Q and sums to obtain total leak of every kind of collimator angle, penetrates factor M.Take minimum M pairs
Optimal collimator angle of the collimator angle answered as every section of arc.
It should be understood that for those of ordinary skills, it can be modified or changed according to the above description,
And all these modifications and variations should all belong to the protection domain of appended claims of the present invention.
Claims (10)
1. a kind of volume rotates intensity modulated radiation therapy plan collimator orientation optimization method, which is characterized in that this method includes following step
It is rapid:
S1, the CT image and structure for obtaining patient construct three-dimensional target region shape；
S2, the target area projection that three-dimensional target region shape carries out two-dimensional projection under each different frame angles is calculated by software simulation
Shape；
S3, the conformal index in target area that different collimator angles are calculated according to projection of shape, and choose optimal solution and suboptimal solution correspondence
Collimator angle；
The optimal solution and the corresponding collimator angle of suboptimal solution that S4, basis obtain draw the rotation of collimator angle random frame angle
One week variation tendency, and determine the segmental radian range of every section of arc in variation tendency；
The segmental radian range that S5, basis obtain calculates the corresponding optimal collimator angle of every section of arc.
2. volume according to claim 1 rotates intensity modulated radiation therapy plan collimator orientation optimization method, which is characterized in that step
Rapid S1's method particularly includes:
The plan CT image of patient and structure are exported with DICOM file format from planning system, and import three-dimensional reconstruction software,
According to the coordinate and structural information progress target area three-dimensional reconstruction in DICOM file.
3. volume according to claim 1 rotates intensity modulated radiation therapy plan collimator orientation optimization method, which is characterized in that step
Rapid S2's method particularly includes:
Rack virtual ray source is simulated by software to rotate a circle around target area geometric center, in a manner of Isocenter irradiation, is calculated
Rack ° rotation counterclockwise from 179 ° to 181 obtains 361 target areas projections at interval of the target area projection of shape under 1 ° altogether, and calculates
The area of every target area projection.
4. volume according to claim 1 rotates intensity modulated radiation therapy plan collimator orientation optimization method, which is characterized in that step
Rapid S3's method particularly includes:
S31, according to obtained target area projection of shape, calculate collimator angle from 0 ° to 180 ° at interval of 1 °, multi-blade collimator pair
The conformal index of target area, conformal index are the ratio of target area area and the area surrounded to also collimators vanes；
S32, ratio indicate that conformal index is more excellent closer to 1, select the corresponding collimation of conformal index of optimal solution and suboptimal solution
Device angle.
5. volume according to claim 1 rotates intensity modulated radiation therapy plan collimator orientation optimization method, which is characterized in that step
Rapid S4's method particularly includes:
S41, by obtained optimal solution and the corresponding collimator angle of suboptimal solution, ° draw and dissipate from 179 ° to 181 according to frame angle
Point diagram and Trendline；
S42, according to the variation tendency and amplitude of collimator angle random frame angle in scatter plot, given threshold, by collimator angle
Spending corresponding continuous rack angular divisions is one section of arc；Every section of arc length is all larger than 30 °, less than 360 °.
6. volume according to claim 1 rotates intensity modulated radiation therapy plan collimator orientation optimization method, which is characterized in that step
Rapid S5's method particularly includes:
S51, the target area projection of shape synthesis union projection to being obtained under all frame angles in every section of arc range；
S52, it is projected according to union, respectively with the multi-blade collimator of 0 ° to 180 ° collimator angle, conformal union is gone to project, and count
Calculate the area that multi-blade collimator surrounds；
S53, the area surrounded according to the multi-blade collimator of obtained each collimator angle, calculating multi-blade collimator surround surplus
Lap product simultaneously carries out weighted sum summation, and collimator angle corresponding to the optimal solution of summation is the optimal collimator angle of every section of arc
Degree.
7. volume according to claim 6 rotates intensity modulated radiation therapy plan collimator orientation optimization method, which is characterized in that step
Rapid S53's method particularly includes:
S531, it is subtracted in section arc under all frame angles with the area that the multi-blade collimator of every kind of obtained collimator angle surrounds
Obtained target area projection, obtains the residual area Pi that the multi-blade collimator under each frame angle surrounds；
S532, weighted factor Wi relevant to the target area projected area of this frame angle to residual area Pi are weighted and are leaked
Penetrate factor Q i；
S533, the leakage under all frame angles in the section arc under every kind of collimator angle is penetrated factor Q i sum to obtain total leakage penetrate because
Sub- M；
S534, optimal solution is sought the M of all collimator angles, defining collimator angle corresponding to M is the optimal collimation of this section of arc
Device angle.
8. volume according to claim 5 rotates intensity modulated radiation therapy plan collimator orientation optimization method, which is characterized in that step
Threshold value setting in rapid S42 are as follows: 10%, 15%, 20%, 25% or 30%.
9. volume according to claim 7 rotates intensity modulated radiation therapy plan collimator orientation optimization method, which is characterized in that step
The formula of weighted factor Wi is calculated in rapid S532 are as follows:
Wherein, Si is expressed as the area of the projection of the target area under each frame angle, and Sc is under frame angle all in this section of arc
The sum of the area of target area projection.
10. volume according to claim 7 rotates intensity modulated radiation therapy plan collimator orientation optimization method, which is characterized in that
The calculation formula of factor Q i is penetrated in leakage in step S532 are as follows:
Qi=Pi*Wi
Wherein, Pi is expressed as the residual area that multi-blade collimator surrounds under a kind of each frame angle of collimator angle, and Wi is
Weighted factor.
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