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CN109394595A - Facial mask essence with deep water supplement and barrier reparation - Google Patents

Facial mask essence with deep water supplement and barrier reparation Download PDF

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Publication number
CN109394595A
CN109394595A CN201811525294.4A CN201811525294A CN109394595A CN 109394595 A CN109394595 A CN 109394595A CN 201811525294 A CN201811525294 A CN 201811525294A CN 109394595 A CN109394595 A CN 109394595A
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China
Prior art keywords
facial mask
deep water
water supplement
mask essence
barrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811525294.4A
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Chinese (zh)
Inventor
杨翠兰
曾家荣
林华娟
邱太龙
赖海玉
李嘉欣
周家灵
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nox Bellcow Cosmetics Co Ltd
Original Assignee
Nox Bellcow Cosmetics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nox Bellcow Cosmetics Co Ltd filed Critical Nox Bellcow Cosmetics Co Ltd
Priority to CN201811525294.4A priority Critical patent/CN109394595A/en
Publication of CN109394595A publication Critical patent/CN109394595A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)

Abstract

A kind of facial mask essence with deep water supplement and barrier reparation, formulation weight proportion splits yeast tunning filtrate: 10%-97% for two, purified water: 0%-90%, allantoin: 0.1%-0.2%, polyalcohol: 1%-8%, polyglycereol moisturizer: 0.5%-2%, EDETATE SODIUM: 0.02%-0.1%, fragrant fresh ketone: 0.3%-0.6%1, 2- hexylene glycol: 0.3%-0.6%, carbomer: 0.1%-0.2%, arginine: 0.1%-0.2%, Sodium Hyaluronate: 0.01%-0.1%, hydroxyethyl cellulose: 0.01%-0.1%, hydroxylated lecithin: 0.1%-0.2%;Has effects that deep water supplement.Has the function of barrier reparation.

Description

Facial mask essence with deep water supplement and barrier reparation
Technical field
This patent is related to a kind of facial mask essence with deep water supplement and barrier reparation, belongs to cosmetic technical field.
Technical background
Facial mask is a kind of dosage form important in cosmetics, and share is also to be increasing year by year, and is attributed to facial mask use It is convenient, it is convenient for carrying and the advantages such as cost performance height.But with the development of the times, consumer is to the functional of purchase product It is required that also higher and higher, facial mask is no longer declaring for certain some simple additive of past, and customer demand facial mask has certain It is both effectiveness, wherein depth moisturizing and to have the effect of certain repair be the most urgent demand of consumer.And it is traditional in the past Facial mask inside, it is basic or carry out declaring for replenishing water and preserving moisture by polyalcohol and some carbohydrate moisturizer, due to moisturizer Property and the reasons such as molecular weight, be the moisturizing effects that can not reach deep skin and long-acting moisturizing, due to skin The missing of moisture, influence of the environment to skin, gets off for a long time in addition, and the screen effect of skin will be damaged, to will lead to The more serious problem of skin.It can be seen that the necessity of a depth MASQUE APAISANT HYDRATANT of exploitation.
Fermentation is more popular biotechnology in recent years, refers to that the life by microorganism under aerobic or oxygen free condition is living It moves to prepare the process of microbial cells itself or directly metabolite or secondary metabolite.Two split yeast tunning Filtrate is a kind of bioactive ingredients that long Bifidobacterium Bifidum is obtained in the environment of anaerobism by fermentation technique, is mainly contained Low molecular polypeptide, amino acid, polysaccharide, minerals and some vitamins.Compared with traditional moisturizer, two split yeast hair Ferment Product filtrate raw material comes from naturally, milder to skin, more friendly to environment, is to be adapted for use in cosmetics very much Raw material.Therefore it uses in the invention as the core component for reaching effect.
Summary of the invention
The facial mask essence with deep water supplement and barrier reparation that it is an object of the present invention to provide a kind of, it is with deep layer The effect of moisturizing and barrier reparation.
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, by following components:
The sum of above each raw material weight percentage is 100%.
The facial mask essence with deep water supplement and barrier reparation, is characterized in that wherein polyalcohol packet Containing glycerol, propylene glycol, 1,3-PD, butanediol, one or more of methyl propanediol.
The facial mask essence with deep water supplement and barrier reparation is characterized in that wherein polyglycereol guarantor Humectant includes: one of diglycerol, polyglycereol -6, Natrulon H-10;
The facial mask essence with deep water supplement and barrier reparation is characterized in that wherein when two split ferment For female tunning filtrate weight proportion in 10%-85%, which has deep water supplement effect, but does not have barrier Repair.
The facial mask essence with deep water supplement and barrier reparation is characterized in that wherein when two split ferment Female tunning filtrate weight proportion is in 85%-97%, and purified water weight proportion, at 0%, which has The effect of deep water supplement and barrier reparation.
Facial mask essence of the invention can reach the effect of the long-acting moisturizing of depth.
Detailed description of the invention
Fig. 1 is keratoderma moisture content test result figure of the present invention.
Fig. 2 is the effect picture of present invention test TEWL.
Fig. 3 is the present invention to test the effect picture of the moisture content of the depths skin 0.5mm.
Fig. 4 is the effect picture that skin barrier of the present invention repairs effect.
Specific embodiment
The present invention is further illustrated below by specific embodiment, reference examples, it is to be understood that, it is these embodiments, right It is only used for specifically describing in more detail as usual being used, but should not be understood as present invention is limited in any form.
Embodiment 1:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Preparation method is according to the following steps:
(1) carbomer, Sodium Hyaluronate, hydroxyethyl cellulose, fragrant fresh ketone, EDETATE SODIUM, allantoin are added to glycerol In (or butanediol), stir evenly;
(2) purified water and two is added to split yeast tunning filtrate and be added in the mixture of step 1, stirring to no particle State;
(3) arginine is stirred to viscous liquid state;
(4) diglycerol (or Natrulon H-10) is added, 1,2- hexylene glycol and hydroxylated lecithin stir evenly, and discharge;
Embodiment 2:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Embodiment 3:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Comparative example 1:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Preparation method is according to the following steps:
(1) carbomer, Sodium Hyaluronate, hydroxyethyl cellulose, fragrant fresh ketone, EDETATE SODIUM, allantoin are added to glycerol In (or butanediol), stir evenly;
(2) purified water and two is added to split yeast tunning filtrate and be added in the mixture of step 1, stirring to no particle State;
(3) arginine is stirred to viscous liquid state;
(4) diglycerol (or Natrulon H-10) is added, 1,2- hexylene glycol and hydroxylated lecithin stir evenly, and discharge.
Comparative example 2:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Comparative example 3:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Comparative example 4:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Each composition of above-mentioned preparation is used to test, to test cuticula moisture content:
Test method is as follows: being carried out using the Corneometer CM825 moisture of skin tester from German CK company. About 0.2 gram of each group template is added drop-wise to the 4cm marked in advance on the arm of volunteer once a day2Square region in, Template is uniformly smeared in the area.Preceding and use rear 0.5h, 1h, 2h, 4h, 6h and use are used with Instrument measuring sample Keratoderma moisture content after 7 days, each region retest are averaged three times.Test results are shown in figure 1.
Each composition of above-mentioned preparation is used to test, to test TEWL (transepidermal water loss rate).Test method is as follows: using VapoMeter moisture of skin tester from DELFIN company carries out.About 0.2 gram of each group template is added drop-wise to once a day The 4cm marked in advance on the arm of volunteer2Square region in, template is uniformly smeared in the area.It is surveyed with instrument Random sample product use TEWL (transepidermal water loss rate) preceding and using rear 0.5h, 1h, 2h, 4h, 6h and after using 7 days, each region Retest is averaged three times.Test results are shown in figure 2.
Two groups of EXPERIMENTAL EXAMPLEs 3 and comparative example 1 statistics indicate that, in comparative example 1 without two split yeast tunning filtrate remaining Ingredient is same as Example 3, and ingredient and commercially available facial mask ingredient are substantially similar in comparative example 1.It can be seen that being handled with embodiment 3 After 0.5h, the moisture content of cuticula is than before being not used higher by 33.17%, and after TEWL (transepidermal water loss rate) handles 0.5h Transepidermal water loss rate is than untreated preceding low 4.73%, and the moisture content of cuticula and TEWL can still be tieed up after using 6h Hold the level higher than before using, although and it can be seen that have raising using cuticula moisture content after 0.5h in comparative example 1, Low 25.55% compared with implementation 3, and cuticula moisture content maintains an equal level with before being not used substantially after using 7 days, percutaneous The level for reaching embodiment 3 is also failed in the test of percentage of water loss, it was demonstrated that no two split the facial mask essence of yeast tunning filtrate It can not carry out lasting water lock ability for skin tape.
Embodiment 1 equally splits the filter of yeast tunning containing two that weight percent is 10% compared with comparative example 2-4 Liquid, the type of polyalcohol does not have in comparative example 2, and the type of polyglycereol moisturizer is different in comparative example 3, in addition to two in comparative example 4 It is constant outer to split yeast tunning filtrate weight percentage, remaining moisturizer composition by weight percent is higher than in embodiment 1.By angle Matter layer water content test data shows that comparative example 2 and 3 and 1 cuticula moisture content of embodiment are substantially unchanged, illustrates polyalcohol Have no effect on moisturizing test result in the present invention with polyglycereol moisturizer type, and 4 mesocuticle moisture content of comparative example have it is micro- Amount rises, but TEWL (transepidermal water loss rate) has no obvious rising, illustrates the weight percent for increasing other moisturizer merely Fail to achieve the effect that skin water lock.
Embodiment 1,2 and 3 compares, statistics indicate that the increase for splitting yeast tunning filtrate weight percentage with two, Cuticula moisture content and TEWL (transepidermal water loss rate) have apparent rising, illustrate in the present invention that a crucial factor is two to split Yeast tunning filtrate.Statistics indicate that after being handled 7 days using template, cuticula moisture content TEWL (transepidermal water loss rate) and still It is able to maintain in higher level, illustrates that moistening effect with higher is split after yeast tunning filtrate in addition two, can expire The demand of sufficient consumer all moisturizings.
The embodiment 1,2 and 3 of preparation is used to test, to test the moisture content of the depths skin 0.5mm, test method is such as Under: it is carried out using the MoistureMeterEpiD tester from DELFIN company.Once a day by about 0.2 gram of each group sample Plate is added drop-wise to the 4cm marked in advance on the arm of volunteer2Square region in, template is uniformly smeared in the area. The moisture of the depths skin 0.5mm with Instrument measuring sample before and using rear 0.5h, 1h, 2h, 4h, 6h and after using 7 days, Each region retest is averaged three times.Test results are shown in figure 3.
Experiment show no matter embodiment 1,2 or 3, deep layer moisture content has rising after handling 0.5h, and consumer is normal Time using facial mask is 20 minutes to 30 minutes, illustrates the use habit that the invention meets consumer to facial mask, uses 0.5h After can depth moisture content can reach peak value, and 3 mid-deep strata moisture content of embodiment obviously rises, and is able to maintain the long period. Illustrate that the invention has effects that deep water supplement.
The embodiment 3 of preparation is used to test, 3D epidermis model E piKutis is based on, passes through lauryl sodium sulfate (Sodium dodecyl sulfate, SLS) stimulation building skin injury model.Then by the way of surface administration, uniformly It is coated on " SLS-EpiKutis " skin injury model surface, by detection model organizational vitality, evaluates the skin of sample to be tested Barrier repairs effect.Test method is as follows: setting negative control group, positive controls and cam group, negative control group draw 20 μ L 5%SLS is dissolved in 480 μ L PBS, is configured to 0.2%SLS working solution, spare.Positive controls by 0.1% dexamethasone and 0.4%SLS is isometric (each 200 μ L), and mixing is configured to 400 μ L, 0.05% dexamethasone+0.2%SLS working solution, spare. Cam group takes 40 μ L 5%SLS mother liquors to be dissolved in the template of 960 μ L embodiments 3 preparation, mixes well, spare.By above-mentioned 3 groups of tables Skin model is transferred in sterile six orifice plate together with the skin model for not smearing template and (adds 0.9mL model culture solution in advance), Test No. is marked on six orifice plates, is placed in CO2Incubator (37 ± 1 DEG C, 5 ± 1%CO2, 95% relative humidity) in, be incubated for 24h.After incubation, start cleaning procedure.Be equipped with sterile PBS solution wash bottle washing moulding tested material remained on surface, PBS is kept to flow out at the uniform velocity, incessantly.After repeated washing 15 times, the inside and outside residual liquid of model is gently wiped away with aseptic cotton carrier. The cleaning total time of each model controls in 1min-2min.MTT method of testing test cell organizational vitality is utilized after the completion.Test As a result as shown in Figure 4.
Experiment shows that positive control is handled using cortex hormone of aadrenaline dexamethasone, has anti-inflammatory effect, and embodiment 3 by SLS processing for 24 hours after, organizational vitality is obviously higher than negative control, illustrate use embodiment 3 after effectively obstruct stimulant into Enter in skin, function and effect are similar with dexamethasone, and in test TEWL, the transepidermal water loss rate of embodiment 3 is minimum, it was demonstrated that implements Example 3 has the function of barrier reparation.

Claims (5)

1. the facial mask essence with deep water supplement and barrier reparation, which is characterized in that formulation weight proportion is as follows:
The sum of above each raw material weight percentage is 100%.
2. the facial mask essence according to claim 1 with deep water supplement and barrier reparation, it is characterised in that: wherein more First alcohol includes glycerol, propylene glycol, 1,3-PD, butanediol, one or more of methyl propanediol.
3. the facial mask essence according to claim 1 or 2 with deep water supplement and barrier reparation, it is characterised in that: its Middle polyglycereol moisturizer includes: one of diglycerol, polyglycereol -6, Natrulon H-10.
4. the facial mask essence according to claim 1 with deep water supplement and barrier reparation, it is characterised in that: wherein when Two split yeast tunning filtrate weight proportion in 10%-85%, which has deep water supplement effect, but does not have There is barrier repair.
5. the facial mask essence according to claim 1 with deep water supplement and barrier reparation, it is characterised in that: wherein when Two split yeast tunning filtrate weight proportion in 85%-97%, and purified water weight proportion is at 0%, the facial mask essence Liquid has the function of deep water supplement and barrier reparation.
CN201811525294.4A 2018-12-13 2018-12-13 Facial mask essence with deep water supplement and barrier reparation Pending CN109394595A (en)

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Application Number Priority Date Filing Date Title
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Publication Number Publication Date
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111588673A (en) * 2020-07-01 2020-08-28 于慧敏 Freeze-dried solid mask and preparation method thereof
CN112472614A (en) * 2019-10-09 2021-03-12 广东丸美生物技术股份有限公司 Anhydrous hyaluronic acid essence and preparation method thereof

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CN102670478A (en) * 2012-04-20 2012-09-19 诺斯贝尔(中山)无纺日化有限公司 Multi-effect restoring skin cream
CN106074355A (en) * 2016-07-15 2016-11-09 上海萧雅生物科技股份有限公司 Have moisture-keeping function plants extraction yeast astringent composition and preparation method thereof
CN108272645A (en) * 2018-03-15 2018-07-13 广州市安语堂生物科技有限公司 The anti-ageing facial mask essence and preparation method thereof for splitting yeast tunning cell lysis object containing two

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN102670478A (en) * 2012-04-20 2012-09-19 诺斯贝尔(中山)无纺日化有限公司 Multi-effect restoring skin cream
CN106074355A (en) * 2016-07-15 2016-11-09 上海萧雅生物科技股份有限公司 Have moisture-keeping function plants extraction yeast astringent composition and preparation method thereof
CN108272645A (en) * 2018-03-15 2018-07-13 广州市安语堂生物科技有限公司 The anti-ageing facial mask essence and preparation method thereof for splitting yeast tunning cell lysis object containing two

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112472614A (en) * 2019-10-09 2021-03-12 广东丸美生物技术股份有限公司 Anhydrous hyaluronic acid essence and preparation method thereof
CN111588673A (en) * 2020-07-01 2020-08-28 于慧敏 Freeze-dried solid mask and preparation method thereof

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