CN109394595A - Facial mask essence with deep water supplement and barrier reparation - Google Patents
Facial mask essence with deep water supplement and barrier reparation Download PDFInfo
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- CN109394595A CN109394595A CN201811525294.4A CN201811525294A CN109394595A CN 109394595 A CN109394595 A CN 109394595A CN 201811525294 A CN201811525294 A CN 201811525294A CN 109394595 A CN109394595 A CN 109394595A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
A kind of facial mask essence with deep water supplement and barrier reparation, formulation weight proportion splits yeast tunning filtrate: 10%-97% for two, purified water: 0%-90%, allantoin: 0.1%-0.2%, polyalcohol: 1%-8%, polyglycereol moisturizer: 0.5%-2%, EDETATE SODIUM: 0.02%-0.1%, fragrant fresh ketone: 0.3%-0.6%1, 2- hexylene glycol: 0.3%-0.6%, carbomer: 0.1%-0.2%, arginine: 0.1%-0.2%, Sodium Hyaluronate: 0.01%-0.1%, hydroxyethyl cellulose: 0.01%-0.1%, hydroxylated lecithin: 0.1%-0.2%;Has effects that deep water supplement.Has the function of barrier reparation.
Description
Technical field
This patent is related to a kind of facial mask essence with deep water supplement and barrier reparation, belongs to cosmetic technical field.
Technical background
Facial mask is a kind of dosage form important in cosmetics, and share is also to be increasing year by year, and is attributed to facial mask use
It is convenient, it is convenient for carrying and the advantages such as cost performance height.But with the development of the times, consumer is to the functional of purchase product
It is required that also higher and higher, facial mask is no longer declaring for certain some simple additive of past, and customer demand facial mask has certain
It is both effectiveness, wherein depth moisturizing and to have the effect of certain repair be the most urgent demand of consumer.And it is traditional in the past
Facial mask inside, it is basic or carry out declaring for replenishing water and preserving moisture by polyalcohol and some carbohydrate moisturizer, due to moisturizer
Property and the reasons such as molecular weight, be the moisturizing effects that can not reach deep skin and long-acting moisturizing, due to skin
The missing of moisture, influence of the environment to skin, gets off for a long time in addition, and the screen effect of skin will be damaged, to will lead to
The more serious problem of skin.It can be seen that the necessity of a depth MASQUE APAISANT HYDRATANT of exploitation.
Fermentation is more popular biotechnology in recent years, refers to that the life by microorganism under aerobic or oxygen free condition is living
It moves to prepare the process of microbial cells itself or directly metabolite or secondary metabolite.Two split yeast tunning
Filtrate is a kind of bioactive ingredients that long Bifidobacterium Bifidum is obtained in the environment of anaerobism by fermentation technique, is mainly contained
Low molecular polypeptide, amino acid, polysaccharide, minerals and some vitamins.Compared with traditional moisturizer, two split yeast hair
Ferment Product filtrate raw material comes from naturally, milder to skin, more friendly to environment, is to be adapted for use in cosmetics very much
Raw material.Therefore it uses in the invention as the core component for reaching effect.
Summary of the invention
The facial mask essence with deep water supplement and barrier reparation that it is an object of the present invention to provide a kind of, it is with deep layer
The effect of moisturizing and barrier reparation.
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, by following components:
The sum of above each raw material weight percentage is 100%.
The facial mask essence with deep water supplement and barrier reparation, is characterized in that wherein polyalcohol packet
Containing glycerol, propylene glycol, 1,3-PD, butanediol, one or more of methyl propanediol.
The facial mask essence with deep water supplement and barrier reparation is characterized in that wherein polyglycereol guarantor
Humectant includes: one of diglycerol, polyglycereol -6, Natrulon H-10;
The facial mask essence with deep water supplement and barrier reparation is characterized in that wherein when two split ferment
For female tunning filtrate weight proportion in 10%-85%, which has deep water supplement effect, but does not have barrier
Repair.
The facial mask essence with deep water supplement and barrier reparation is characterized in that wherein when two split ferment
Female tunning filtrate weight proportion is in 85%-97%, and purified water weight proportion, at 0%, which has
The effect of deep water supplement and barrier reparation.
Facial mask essence of the invention can reach the effect of the long-acting moisturizing of depth.
Detailed description of the invention
Fig. 1 is keratoderma moisture content test result figure of the present invention.
Fig. 2 is the effect picture of present invention test TEWL.
Fig. 3 is the present invention to test the effect picture of the moisture content of the depths skin 0.5mm.
Fig. 4 is the effect picture that skin barrier of the present invention repairs effect.
Specific embodiment
The present invention is further illustrated below by specific embodiment, reference examples, it is to be understood that, it is these embodiments, right
It is only used for specifically describing in more detail as usual being used, but should not be understood as present invention is limited in any form.
Embodiment 1:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Preparation method is according to the following steps:
(1) carbomer, Sodium Hyaluronate, hydroxyethyl cellulose, fragrant fresh ketone, EDETATE SODIUM, allantoin are added to glycerol
In (or butanediol), stir evenly;
(2) purified water and two is added to split yeast tunning filtrate and be added in the mixture of step 1, stirring to no particle
State;
(3) arginine is stirred to viscous liquid state;
(4) diglycerol (or Natrulon H-10) is added, 1,2- hexylene glycol and hydroxylated lecithin stir evenly, and discharge;
Embodiment 2:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Embodiment 3:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Comparative example 1:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Preparation method is according to the following steps:
(1) carbomer, Sodium Hyaluronate, hydroxyethyl cellulose, fragrant fresh ketone, EDETATE SODIUM, allantoin are added to glycerol
In (or butanediol), stir evenly;
(2) purified water and two is added to split yeast tunning filtrate and be added in the mixture of step 1, stirring to no particle
State;
(3) arginine is stirred to viscous liquid state;
(4) diglycerol (or Natrulon H-10) is added, 1,2- hexylene glycol and hydroxylated lecithin stir evenly, and discharge.
Comparative example 2:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Comparative example 3:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Comparative example 4:
A kind of facial mask essence with deep water supplement and barrier reparation, by weight percentage, formulation ratio are as follows:
Each composition of above-mentioned preparation is used to test, to test cuticula moisture content:
Test method is as follows: being carried out using the Corneometer CM825 moisture of skin tester from German CK company.
About 0.2 gram of each group template is added drop-wise to the 4cm marked in advance on the arm of volunteer once a day2Square region in,
Template is uniformly smeared in the area.Preceding and use rear 0.5h, 1h, 2h, 4h, 6h and use are used with Instrument measuring sample
Keratoderma moisture content after 7 days, each region retest are averaged three times.Test results are shown in figure 1.
Each composition of above-mentioned preparation is used to test, to test TEWL (transepidermal water loss rate).Test method is as follows: using
VapoMeter moisture of skin tester from DELFIN company carries out.About 0.2 gram of each group template is added drop-wise to once a day
The 4cm marked in advance on the arm of volunteer2Square region in, template is uniformly smeared in the area.It is surveyed with instrument
Random sample product use TEWL (transepidermal water loss rate) preceding and using rear 0.5h, 1h, 2h, 4h, 6h and after using 7 days, each region
Retest is averaged three times.Test results are shown in figure 2.
Two groups of EXPERIMENTAL EXAMPLEs 3 and comparative example 1 statistics indicate that, in comparative example 1 without two split yeast tunning filtrate remaining
Ingredient is same as Example 3, and ingredient and commercially available facial mask ingredient are substantially similar in comparative example 1.It can be seen that being handled with embodiment 3
After 0.5h, the moisture content of cuticula is than before being not used higher by 33.17%, and after TEWL (transepidermal water loss rate) handles 0.5h
Transepidermal water loss rate is than untreated preceding low 4.73%, and the moisture content of cuticula and TEWL can still be tieed up after using 6h
Hold the level higher than before using, although and it can be seen that have raising using cuticula moisture content after 0.5h in comparative example 1,
Low 25.55% compared with implementation 3, and cuticula moisture content maintains an equal level with before being not used substantially after using 7 days, percutaneous
The level for reaching embodiment 3 is also failed in the test of percentage of water loss, it was demonstrated that no two split the facial mask essence of yeast tunning filtrate
It can not carry out lasting water lock ability for skin tape.
Embodiment 1 equally splits the filter of yeast tunning containing two that weight percent is 10% compared with comparative example 2-4
Liquid, the type of polyalcohol does not have in comparative example 2, and the type of polyglycereol moisturizer is different in comparative example 3, in addition to two in comparative example 4
It is constant outer to split yeast tunning filtrate weight percentage, remaining moisturizer composition by weight percent is higher than in embodiment 1.By angle
Matter layer water content test data shows that comparative example 2 and 3 and 1 cuticula moisture content of embodiment are substantially unchanged, illustrates polyalcohol
Have no effect on moisturizing test result in the present invention with polyglycereol moisturizer type, and 4 mesocuticle moisture content of comparative example have it is micro-
Amount rises, but TEWL (transepidermal water loss rate) has no obvious rising, illustrates the weight percent for increasing other moisturizer merely
Fail to achieve the effect that skin water lock.
Embodiment 1,2 and 3 compares, statistics indicate that the increase for splitting yeast tunning filtrate weight percentage with two,
Cuticula moisture content and TEWL (transepidermal water loss rate) have apparent rising, illustrate in the present invention that a crucial factor is two to split
Yeast tunning filtrate.Statistics indicate that after being handled 7 days using template, cuticula moisture content TEWL (transepidermal water loss rate) and still
It is able to maintain in higher level, illustrates that moistening effect with higher is split after yeast tunning filtrate in addition two, can expire
The demand of sufficient consumer all moisturizings.
The embodiment 1,2 and 3 of preparation is used to test, to test the moisture content of the depths skin 0.5mm, test method is such as
Under: it is carried out using the MoistureMeterEpiD tester from DELFIN company.Once a day by about 0.2 gram of each group sample
Plate is added drop-wise to the 4cm marked in advance on the arm of volunteer2Square region in, template is uniformly smeared in the area.
The moisture of the depths skin 0.5mm with Instrument measuring sample before and using rear 0.5h, 1h, 2h, 4h, 6h and after using 7 days,
Each region retest is averaged three times.Test results are shown in figure 3.
Experiment show no matter embodiment 1,2 or 3, deep layer moisture content has rising after handling 0.5h, and consumer is normal
Time using facial mask is 20 minutes to 30 minutes, illustrates the use habit that the invention meets consumer to facial mask, uses 0.5h
After can depth moisture content can reach peak value, and 3 mid-deep strata moisture content of embodiment obviously rises, and is able to maintain the long period.
Illustrate that the invention has effects that deep water supplement.
The embodiment 3 of preparation is used to test, 3D epidermis model E piKutis is based on, passes through lauryl sodium sulfate
(Sodium dodecyl sulfate, SLS) stimulation building skin injury model.Then by the way of surface administration, uniformly
It is coated on " SLS-EpiKutis " skin injury model surface, by detection model organizational vitality, evaluates the skin of sample to be tested
Barrier repairs effect.Test method is as follows: setting negative control group, positive controls and cam group, negative control group draw 20 μ
L 5%SLS is dissolved in 480 μ L PBS, is configured to 0.2%SLS working solution, spare.Positive controls by 0.1% dexamethasone and
0.4%SLS is isometric (each 200 μ L), and mixing is configured to 400 μ L, 0.05% dexamethasone+0.2%SLS working solution, spare.
Cam group takes 40 μ L 5%SLS mother liquors to be dissolved in the template of 960 μ L embodiments 3 preparation, mixes well, spare.By above-mentioned 3 groups of tables
Skin model is transferred in sterile six orifice plate together with the skin model for not smearing template and (adds 0.9mL model culture solution in advance),
Test No. is marked on six orifice plates, is placed in CO2Incubator (37 ± 1 DEG C, 5 ± 1%CO2, 95% relative humidity) in, be incubated for
24h.After incubation, start cleaning procedure.Be equipped with sterile PBS solution wash bottle washing moulding tested material remained on surface,
PBS is kept to flow out at the uniform velocity, incessantly.After repeated washing 15 times, the inside and outside residual liquid of model is gently wiped away with aseptic cotton carrier.
The cleaning total time of each model controls in 1min-2min.MTT method of testing test cell organizational vitality is utilized after the completion.Test
As a result as shown in Figure 4.
Experiment shows that positive control is handled using cortex hormone of aadrenaline dexamethasone, has anti-inflammatory effect, and embodiment
3 by SLS processing for 24 hours after, organizational vitality is obviously higher than negative control, illustrate use embodiment 3 after effectively obstruct stimulant into
Enter in skin, function and effect are similar with dexamethasone, and in test TEWL, the transepidermal water loss rate of embodiment 3 is minimum, it was demonstrated that implements
Example 3 has the function of barrier reparation.
Claims (5)
1. the facial mask essence with deep water supplement and barrier reparation, which is characterized in that formulation weight proportion is as follows:
The sum of above each raw material weight percentage is 100%.
2. the facial mask essence according to claim 1 with deep water supplement and barrier reparation, it is characterised in that: wherein more
First alcohol includes glycerol, propylene glycol, 1,3-PD, butanediol, one or more of methyl propanediol.
3. the facial mask essence according to claim 1 or 2 with deep water supplement and barrier reparation, it is characterised in that: its
Middle polyglycereol moisturizer includes: one of diglycerol, polyglycereol -6, Natrulon H-10.
4. the facial mask essence according to claim 1 with deep water supplement and barrier reparation, it is characterised in that: wherein when
Two split yeast tunning filtrate weight proportion in 10%-85%, which has deep water supplement effect, but does not have
There is barrier repair.
5. the facial mask essence according to claim 1 with deep water supplement and barrier reparation, it is characterised in that: wherein when
Two split yeast tunning filtrate weight proportion in 85%-97%, and purified water weight proportion is at 0%, the facial mask essence
Liquid has the function of deep water supplement and barrier reparation.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111588673A (en) * | 2020-07-01 | 2020-08-28 | 于慧敏 | Freeze-dried solid mask and preparation method thereof |
CN112472614A (en) * | 2019-10-09 | 2021-03-12 | 广东丸美生物技术股份有限公司 | Anhydrous hyaluronic acid essence and preparation method thereof |
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CN106074355A (en) * | 2016-07-15 | 2016-11-09 | 上海萧雅生物科技股份有限公司 | Have moisture-keeping function plants extraction yeast astringent composition and preparation method thereof |
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CN102670478A (en) * | 2012-04-20 | 2012-09-19 | 诺斯贝尔(中山)无纺日化有限公司 | Multi-effect restoring skin cream |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112472614A (en) * | 2019-10-09 | 2021-03-12 | 广东丸美生物技术股份有限公司 | Anhydrous hyaluronic acid essence and preparation method thereof |
CN111588673A (en) * | 2020-07-01 | 2020-08-28 | 于慧敏 | Freeze-dried solid mask and preparation method thereof |
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