CN109374913A - A kind of liquid channel system device and control method - Google Patents
A kind of liquid channel system device and control method Download PDFInfo
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- CN109374913A CN109374913A CN201811038627.0A CN201811038627A CN109374913A CN 109374913 A CN109374913 A CN 109374913A CN 201811038627 A CN201811038627 A CN 201811038627A CN 109374913 A CN109374913 A CN 109374913A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
- G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1034—Transferring microquantities of liquid
- G01N2035/1039—Micropipettes, e.g. microcapillary tubes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of liquid channel system device and control methods, including sample needle, it is connected to the sample needle and compressing control mechanism for controlling the sample needle compressing precision, is connected to the compressing control mechanism and for stablizing the liquid channel system stabilizing mechanism of fluid path system water pressure, the pipeline being connected between each mechanism and sample needle rinse bath for cleaning the sample needle outer wall, by reducing the carrying generated in sample filling process pollution, cooperate the mode of continuous-stable high-precision sample addition, to guarantee the result high-precision of micro sample-adding.
Description
Technical field
The present invention relates to a kind of medical instruments, more specifically, it relates to a kind of liquid channel system device and control method.
Background technique
With the continuous growth of clinical diagnosis demand and the continuous improvement of research and development technology, in-vitro diagnosis (IVD) industry is
It is with fastest developing speed in pharmaceuticals industry through becoming, and one of industry the most active.
In-vitro diagnosis carries out vitro detection to human sample (various body fluid, cell, tissue samples etc.), to reach disease
Prevention, diagnosis, Treatment monitoring, Observation On The Prognosis, health status is evaluated and the prediction effect of genetic disease.
However equipment, during carrying out data analysis to human sample, but inevitably there is testing results to deposit
The relatively large deviation the problem of, or even there are the serious problems such as false retrieval, erroneous detection.And the method for avoiding these problems has gone out reduction artificially
The external factors such as maloperation are then more to start with from equipment itself.
The possibility for influencing equipment detection accuracy has very much.Such as: the sample and reagent additive amount that provide are detected for equipment
The inaccuracy of test result caused by inaccuracy causes reaction solution inaccurate；The vessel for providing reaction and observation are cleaning dirty, repeatedly
Different sample cross contaminations cause reaction liquid from polluting after detection, to influence test result；Equipment testing process is unreasonable, causes
Result error；The problems such as reagent, sample are rotten etc..
Biochemical Analyzer belongs to optic analytical instrument, and testing principle is the selective absorbing based on substance to light, that is, divides
Light photometry.The polychromatic light that light source issues is divided into monochromatic light by monochromator, and the monochromatic light of specific wavelength is by filling sample solution
Cuvette, photoelectric converter, which is converted to transmitted light, to be sent into signal processing system after electric signal and analyzes.
And want continuous optical analysis, it is necessary to continuous sample loading system and continuous cuvette cleaning system and
The cooperation of other related systems.However sample and cleaning process are continuously filled, inevitably there is very high probability to cause sample
Sample cross contamination phenomenon caused by this adding amount is inaccurate, sample is cleaning dirty.
Therefore, it is necessary to a kind of new technological means, to solve the above problems.
Summary of the invention
The object of the present invention is to provide a kind of liquid channel system device and control methods, are produced by reducing in sample filling process
Raw carrying pollution, the mode of cooperation continuous-stable high-precision sample addition, to guarantee the result high-precision of micro sample-adding.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of liquid channel system device, wherein including sample needle, be connected to the sample needle and for controlling the sample needle compressing
The compressing control mechanism of precision is connected to the compressing control mechanism and the liquid channel system stabilization for stablizing fluid path system water pressure
Mechanism, the pipeline being connected between each mechanism and the sample needle rinse bath for cleaning the sample needle outer wall.
The liquid channel system device, wherein the liquid channel system stabilizing mechanism includes setting gradually for providing just
The first order kinetics supply pump of grade head water power, for removing in deionized water the depassing unit of bubble and for stable water supply pressure
The second level current stabilization booster pump of power；The first order kinetics supply pump include supply impeller of pump, the supply impeller of pump for go from
Sub- water carries out pulsed agitation to generate the variation in water pressure of fluctuation-type.
The liquid channel system device, wherein the depassing unit includes vacuum cavity and is arranged in vacuum cavity
Degassing pipeline, the lower end of the vacuum cavity side wall is provided with vacuum interface, and the upper end of the vacuum cavity is provided with into water
Mouth and water outlet；The vacuum cavity be used for for free gas in deionized water provide through it is described deaerate pipeline tube wall and
The vacuum environment of precipitation.
The liquid channel system device, wherein the compressing control mechanism includes being arranged in second level current stabilization booster pump downstream
Huge discharge plunger pump, the huge discharge plunger pump for provide system and device cleaning two sections of power sources of probe inner wall；It is described big
The first control valve is provided between displacement plunger pump and second level current stabilization booster pump.
The liquid channel system device, wherein the downstream of the huge discharge plunger pump is provided with pressure sensor, the pressure
Force snesor is alarmed for detecting pressure change state in liquid channel system when abnormality occurs in liquid channel system device；
The second control valve is provided between the huge discharge plunger pump and pressure sensor.
The liquid channel system device, wherein the downstream of the pressure sensor is provided with draws for high-precision quantitative
The high-precision small-displacement plunger of sample liquid, first control valve, the second control valve and the cooperation of high-precision small-displacement plunger
Trace sample is completed accurately to draw and fill；The sample needle is connected to high-precision small-displacement plunger.
The liquid channel system device, wherein further include being connected to second level current stabilization booster pump and when the first control valve ends
When complete liquid channel system internal pressure release return line.
The liquid channel system device, wherein the sample needle includes needle tubing, is sheathed on the outside of needle tubing and for protecting needle
The sheath of pipe and the connector for being connected to pipeline and needle tubing.
The liquid channel system device, wherein the sample needle rinse bath includes for accommodating sample needle and passing through cleaning solution
Or deionized water completes the inlet of cleaning sample needle outer wall, the waste collection slot of inlet side is arranged in and is arranged in institute
State the discard solution discharge port of waste collection slot one end；The slot bottom of the waste collection slot is provided with inclined-plane, and the discard solution discharge port is set
It sets in the bottom end on inclined-plane.
One kind is based on described in any item liquid channel system control methods as above, wherein includes:
Pressure release control, the first control valve are closed, and second level current stabilization booster pump completes pressure release by return line；
One section of stable high voltage cleaning control, the first control valve are opened simultaneously with the second control valve, and the deionized water made passes sequentially through
First control valve, huge discharge plunger pump, the second control valve, pressure sensor and high-precision small-displacement plunger, finally by adding
The stable high voltage cleaning of sample needle inner wall is completed in the outlet outflow of sample needle；
It inhales sample to control, in stable high voltage cleaning process, the plunger of huge discharge plunger pump is pulled down to be filled deionized water；
Two sections of stable pressure stabilizing cleaning controls, the first control valve are closed, and the second control valve continues starting, the plunger of huge discharge plunger pump
It above pushes away to complete two sections of constant current constant voltage cleanings.
In conclusion the present invention, by reducing the carrying generated in sample filling process pollution, cooperation continuous-stable is high-precision
The mode of sample addition is spent, to guarantee the result high-precision of micro sample-adding；Probe is mainly cleaned using deionised degassed water transformation
Inner wall, to reach the high level of cleanliness of sample needle, reducing sample cross contamination bring influences；Meanwhile this system device is compared
Previous drop sample system and device improves the accuracy of sample infusion volume；The relatively clean reaction of high-precision sample infusion volume cooperation
Environment largely improves final sample precision of analysis, and enabling a device to analysis provides accurate inspection
Test result.
Detailed description of the invention
Fig. 1 is the overall structure diagram of liquid channel system device in the present embodiment.
Fig. 2 is the structural schematic diagram of sample needle in the present embodiment.
Fig. 3 is the structural schematic diagram of depassing unit in the present embodiment.
Fig. 4 is the structural schematic diagram of sample needle rinse bath in the present embodiment.
In figure: 1, first order kinetics supply pump；2, depassing unit；21, vacuum cavity；22, deaerate pipeline；23, water inlet；
24, water outlet；25,；Vacuum interface 3, second level current stabilization booster pump；4, the first control valve；5, huge discharge plunger pump；6, the second control
Valve；7, pressure sensor；8, high-precision small-displacement plunger；9, sample needle；91, needle tubing；92, sheath；93, connector；10, sample
Needle rinse bath；101, inlet；102, waste collection slot；103, discard solution discharge port；11, return line.
Specific embodiment
Below in conjunction with attached drawing, invention is further described in detail.
This specific embodiment is only explanation of the invention, is not limitation of the present invention, those skilled in the art
Member can according to need the modification that not creative contribution is made to the present embodiment after reading this specification, but as long as at this
All by the protection of Patent Law in the scope of the claims of invention.
Embodiment: a kind of liquid channel system device, as shown in Figure 1, include as sample compressing terminal sample needle 9, connection
In the sample needle 9 and compressing control mechanism for controlling the 9 compressing precision of sample needle, it is connected to compressing control machine
Structure and the pipeline for being used to stablize the liquid channel system stabilizing mechanism of fluid path system water pressure and be connected between each mechanism；It further include using
In the sample needle rinse bath for cleaning the sample needle outer wall.
The liquid channel system stabilizing mechanism includes the first order kinetics supply for providing primary head water power set gradually
Pump 1, the depassing unit 2 for removing bubble in deionized water and the second level current stabilization booster pump 3 for stable water supply pressure.Institute
State first order kinetics supply pump 1 include supply impeller of pump, the supply impeller of pump be used for deionized water carry out pulsed stir from
And generate the variation in water pressure of fluctuation-type.
As shown in Fig. 2, the sample needle includes needle tubing 91, is sheathed on 91 outside of needle tubing and the sheath for protecting needle tubing 91
92 and it is connected to the connector 93 of pipeline Yu needle tubing 91.
Wherein, needle tubing 91 completes compressing work for liquid communication, and eventually by end.Since 91 wall of needle tubing is thin and thin
It is long, it is easy to damage because of external scraping collision, therefore be provided with sheath 92 on the outside of needle tubing 91, sheath 92 selects firm material, from
And effective protection is carried out to sample needle 9.The interface that connector 93 is connect as pipeline with sample needle.
As shown in figure 3, the depassing unit includes vacuum cavity 21 and the degassing pipeline being arranged in vacuum cavity 21
22, the lower end of 21 side wall of vacuum cavity is provided with vacuum interface 25, and the upper end of the vacuum cavity 21 is provided with water inlet
23 and water outlet 24；The vacuum cavity 21 is used to provide for free gas in deionized water through the degassing pipeline 22
Tube wall and the vacuum environment being precipitated.
Vacuum cavity 21 is that free gas penetrates the tube wall of degassing pipeline 22 and is precipitated and provides vacuum environment in deionized water,
Vacuum interface 25 is the interface of external vacuum supply arrangement, and 21 internal gas of vacuum cavity detaches by vacuum interface 25, go from
Sub- water is entered the inside of depassing unit by water inlet 23, and flows out depassing unit by water outlet 24.The pipeline 22 that deaerates is preferably fixed
Measure the silicone tube of wall thickness, wall thickness is arranged according to actual needs, characteristic be under vacuum conditions, gone inside the pipeline 22 that deaerates from
Sub- water can not transmural exudation, but in deionized water dissociate gas can by external vacuum penetrate tube wall, by being precipitated in deionized water.
Specifically, first order kinetics supply pump 1 is used for liquid channel system unit feeding deionized water, depassing unit 2 is system
The deionized water degasification flowed through in device, go water removal middle reaches from air, improve sample-adding accuracy.Second level current stabilization booster pump 3 is complete
The increase of supply deionized water and current stabilization in pairs pass through second level current stabilization since the hydraulic pressure that first order kinetics supply pump 1 provides is unstable
After booster pump 3, in the case where improving liquid channel system device inside water pressure, while stable water supply pressure.
By first order kinetics supply pump 1 to liquid channel system unit feeding deionized water, the deionized water supplied at this time is passed through
After supplying the agitation of impeller of pump pulsed, more free bubble is contained in water, these free bubbles are in the mistake for carrying out sample compressing
Cheng Zhong influences the compressing accuracy of small sample amount because opposite deionized water is easier to compress or stretch.And passes through degasification and fill
After setting 2 degassings, the bubble to dissociate in water is removed.
The compressing control mechanism includes the huge discharge plunger pump 5 that 3 downstream of second level current stabilization booster pump is arranged in, the big row
Amount plunger pump 5 is for providing system and device cleaning two sections of power sources of probe inner wall；The huge discharge plunger pump 5 increases with second level current stabilization
The first control valve 4 is provided between press pump 3.
Variation in water pressure of the deionized water because of impulse form generation fluctuation-type after first order kinetics supply pump 1, this change
Change is smaller on the filling influence of larger samples amount, but in small quantity filling, this fluctuation accuracy that extreme influence is final.
Deionized water after degassing is completed to stablize the effect of pressurization by second level current stabilization booster pump 3, goes after the second current stabilization booster pump
Ionized water ripples are dynamic relatively steady consistent.
The downstream of the huge discharge plunger pump 5 is provided with pressure sensor 7, and the pressure sensor 7 is for detecting fluid path
Pressure change state in system is alarmed when abnormality occurs in liquid channel system device；The huge discharge plunger pump 5 and pressure
The second control valve 6 is provided between force snesor 7.Wherein, the first control valve 4 and the second control valve 6 are preferably solenoid valve.
The downstream of the pressure sensor 7 is provided with the high-precision small displacement plunger that sample liquid is drawn for high-precision quantitative
Pump 8, first control valve 4, the second control valve 6 and the cooperation of high-precision small-displacement plunger 8 are completed trace sample and are accurately drawn
And filling.The sample needle 9 is connected to high-precision small-displacement plunger 8.
This liquid channel system device further includes being connected to second level current stabilization booster pump 3 and completing liquid when the cut-off of the first control valve 4
The return line 11 of road internal system pressure release.
Specifically, required boost pressure, which can adjust sample needle 9 by change 11 latus rectum of booster pump return line, exports side pressure
Force value, online maximum pressure is the second current stabilization booster pump pressure itself limit.
As shown in figure 4, the sample needle rinse bath 10 include for accommodate sample needle 9 and by cleaning solution or deionized water it is complete
At the inlet of cleaning sample needle outer wall, the waste collection slot of inlet side is set and is arranged in the waste collection slot
The discard solution discharge port of one end；The slot bottom of the waste collection slot is provided with inclined-plane, and the bottom on inclined-plane is arranged in the discard solution discharge port
End.
Liquid for cleaning sample needle 9 is entered by inlet 101, and sample needle is rinsed in the cleaning liquid impact with pressure
9 outer wall completes cleaning, and wherein cleaning solution or deionized water can be selected in cleaning solution.The waste liquid for having cleaned 9 outer wall of sample needle flows into
In waste collection slot 102, discard solution discharge port 103 is flow to by the inclined-plane of 102 slot bottom of waste collection slot, waste liquid is by discard solution discharge port
It is discharged after being flowed at 103.
Further, plunger pump power source is stepper motor, and not only pulse is minimum, but also plunger reasoning is uniform.So that the
Two control valves 6 are very steady to the liquid channel system internal pressure between the outlet of sample needle 9.When use high-precision small-displacement plunger
When 8 absorption sample, smoothly environment can promote the accuracy that sample is drawn and filled inside liquid channel system.And then directly promote inspection
The detection performance of measurement equipment.
Working principle, the branch that the first control valve 4 cooperates the second control valve 6 to complete deionized water select supply, specifically,
When the first control valve 4 is closed, second level current stabilization booster pump 3 completes pressure release by return line 11.It avoids the time from building the pressure to cause
Component damage.When the first control valve 4, the second control valve 6 open simultaneously, deionized water once passes through the first control valve 4, big
Displacement plunger pump 5, the second control valve 6, pressure sensor 7, high-precision small-displacement plunger 8 are finally exported by sample needle 9 and are flowed out
Complete one section of stable high voltage cleaning of 9 inner wall of sample needle.
Stablize in cleaning process, the plunger of huge discharge plunger pump 5 is pulled down to be filled deionized water, when first segment stable high voltage
After cleaning, the first control valve 4 is closed, and the second control valve 6 continues starting.The plunger of huge discharge plunger pump 5 above pushes away, and starts the
Two sections of constant current constant voltage cleanings.Sample needle 9 after the cleaning of multistage different pressures, sample carry pollution and will greatly be controlled
System has ensured the relatively clean of sample needle 9, and the final accuracy for equipment detection provides the foundation.
The embodiment of the invention also provides be based on liquid channel system control method as described above, comprising:
Pressure release control, the first control valve are closed, and second level current stabilization booster pump completes pressure release by return line；
One section of stable high voltage cleaning control, the first control valve are opened simultaneously with the second control valve, and the deionized water made passes sequentially through
First control valve, huge discharge plunger pump, the second control valve, pressure sensor and high-precision small-displacement plunger, finally by adding
The stable high voltage cleaning of sample needle inner wall is completed in the outlet outflow of sample needle；
It inhales sample to control, in stable high voltage cleaning process, the plunger of huge discharge plunger pump is pulled down to be filled deionized water；
Two sections of stable pressure stabilizing cleaning controls, the first control valve are closed, and the second control valve continues starting, the plunger of huge discharge plunger pump
It above pushes away to complete two sections of constant current constant voltage cleanings；As detailed above.
To sum up, the present invention cooperates continuous-stable high-precision sample by reducing the carrying generated in sample filling process pollution
The mode of this addition, to guarantee the result high-precision of micro sample-adding.It is mainly used in deionised degassed water transformation cleaning probe
Wall, to reach the high level of cleanliness of sample needle, reducing sample cross contamination bring influences.Meanwhile this system device compare with
The accuracy of sample infusion volume is improved toward drop sample system and device.The relatively clean reaction ring of high-precision sample infusion volume cooperation
Border largely improves final sample precision of analysis, and enabling a device to analysis provides accurate inspection
As a result.
It should be understood that the application of the present invention is not limited to the above for those of ordinary skills can
With improvement or transformation based on the above description, all these modifications and variations all should belong to the guarantor of appended claims of the present invention
Protect range.
Claims (10)
1. a kind of liquid channel system device, it is characterized in that: including sample needle, being connected to the sample needle and for controlling the sample-adding
The compressing control mechanism of needle compressing precision is connected to the compressing control mechanism and the fluid path system for stablizing fluid path system water pressure
System stabilizing mechanism, the pipeline being connected between each mechanism and the sample needle rinse bath for cleaning the sample needle outer wall.
2. liquid channel system device according to claim 1, it is characterized in that: the liquid channel system stabilizing mechanism includes successively setting
The first order kinetics supply pump for providing primary head water power set, for remove in deionized water the depassing unit of bubble and
Second level current stabilization booster pump for stable water supply pressure；The first order kinetics supply pump includes supply impeller of pump, the supply pump
Impeller is used to carry out deionized water pulsed agitation to generate the variation in water pressure of fluctuation-type.
3. liquid channel system device according to claim 2, it is characterized in that: the depassing unit includes vacuum cavity and sets
It sets in the intracorporal degassing pipeline of vacuum chamber, the lower end of the vacuum cavity side wall is provided with vacuum interface, the vacuum cavity
Upper end is provided with water inlet and water outlet；The vacuum cavity is used to provided for free gas in deionized water through described de-
The tube wall of air pipe and the vacuum environment being precipitated.
4. liquid channel system device according to claim 1, it is characterized in that: the compressing control mechanism includes being arranged in second level
The huge discharge plunger pump in current stabilization booster pump downstream, the huge discharge plunger pump clean two sections of probe inner wall for providing system and device
Power source；The first control valve is provided between the huge discharge plunger pump and second level current stabilization booster pump.
5. liquid channel system device according to claim 4, it is characterized in that: the downstream of the huge discharge plunger pump is provided with pressure
Force snesor, the pressure sensor occur abnormal for detecting pressure change state in liquid channel system in liquid channel system device
It alarms when state；The second control valve is provided between the huge discharge plunger pump and pressure sensor.
6. liquid channel system device according to claim 5, it is characterized in that: the downstream of the pressure sensor is provided with and is used for
High-precision quantitative draws the high-precision small-displacement plunger of sample liquid, and first control valve, the second control valve and high-precision are small
Displacement plunger pump cooperation completes trace sample and accurately draws and fill；The sample needle is connected to high-precision small displacement plunger
Pump.
7. liquid channel system device according to claim 4, it is characterized in that: further including being connected to second level current stabilization booster pump and working as
The return line of liquid channel system internal pressure release is completed when first control valve ends.
8. liquid channel system device according to claim 1, it is characterized in that: the sample needle includes needle tubing, is sheathed on needle tubing
Outside and for protecting the sheath of needle tubing and being connected to the connector of pipeline and needle tubing.
9. liquid channel system device according to claim 8, it is characterized in that: the sample needle rinse bath includes for accommodating sample-adding
Needle and the inlet of cleaning sample needle outer wall is completed by cleaning solution or deionized water, the waste collection of inlet side is set
Slot and the discard solution discharge port that waste collection slot one end is set；The slot bottom of the waste collection slot is provided with inclined-plane, institute
State the bottom end that inclined-plane is arranged in discard solution discharge port.
10. a kind of based on liquid channel system control method described in claim 1-9, characterized in that include:
Pressure release control, the first control valve are closed, and second level current stabilization booster pump completes pressure release by return line；
One section of stable high voltage cleaning control, the first control valve are opened simultaneously with the second control valve, and the deionized water made passes sequentially through
First control valve, huge discharge plunger pump, the second control valve, pressure sensor and high-precision small-displacement plunger, finally by adding
The stable high voltage cleaning of sample needle inner wall is completed in the outlet outflow of sample needle；
It inhales sample to control, in stable high voltage cleaning process, the plunger of huge discharge plunger pump is pulled down to be filled deionized water；
Two sections of stable pressure stabilizing cleaning controls, the first control valve are closed, and the second control valve continues starting, the plunger of huge discharge plunger pump
It above pushes away to complete two sections of constant current constant voltage cleanings.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811038627.0A CN109374913B (en) | 2018-09-06 | 2018-09-06 | Liquid path system device and control method |
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| CN201811038627.0A CN109374913B (en) | 2018-09-06 | 2018-09-06 | Liquid path system device and control method |
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| CN109374913B CN109374913B (en) | 2022-06-14 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110187138A (en) * | 2019-07-02 | 2019-08-30 | 安图实验仪器(郑州)有限公司 | Sample needle cleaning solution drainage system for in-vitro diagnosis equipment |
| CN111830270A (en) * | 2020-07-09 | 2020-10-27 | 迪瑞医疗科技股份有限公司 | Precise sample adding system, in-vitro diagnosis equipment and precise sample adding method |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH028746A (en) * | 1988-06-27 | 1990-01-12 | Hitachi Ltd | Analyzer |
| US5474744A (en) * | 1993-10-28 | 1995-12-12 | Hoffmann-La Roche Inc. | Automatic pipetting device with cleaning mechanism |
| US20030223472A1 (en) * | 2002-05-29 | 2003-12-04 | Ravalico Patricia H. | Clinical tester wash and method |
| CN1471639A (en) * | 2000-10-24 | 2004-01-28 | ������������ʽ���� | Automatic pipette arrangement with cleaning arrangement |
| CN203299211U (en) * | 2013-06-18 | 2013-11-20 | 东软安德医疗科技有限公司 | Liquid feeding and draining system of full-automatic biochemical analyzer |
| CN105143890A (en) * | 2013-04-22 | 2015-12-09 | 株式会社日立高新技术 | Automatic analysis device |
-
2018
- 2018-09-06 CN CN201811038627.0A patent/CN109374913B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH028746A (en) * | 1988-06-27 | 1990-01-12 | Hitachi Ltd | Analyzer |
| US5474744A (en) * | 1993-10-28 | 1995-12-12 | Hoffmann-La Roche Inc. | Automatic pipetting device with cleaning mechanism |
| CN1471639A (en) * | 2000-10-24 | 2004-01-28 | ������������ʽ���� | Automatic pipette arrangement with cleaning arrangement |
| US20030223472A1 (en) * | 2002-05-29 | 2003-12-04 | Ravalico Patricia H. | Clinical tester wash and method |
| CN105143890A (en) * | 2013-04-22 | 2015-12-09 | 株式会社日立高新技术 | Automatic analysis device |
| CN203299211U (en) * | 2013-06-18 | 2013-11-20 | 东软安德医疗科技有限公司 | Liquid feeding and draining system of full-automatic biochemical analyzer |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110187138A (en) * | 2019-07-02 | 2019-08-30 | 安图实验仪器(郑州)有限公司 | Sample needle cleaning solution drainage system for in-vitro diagnosis equipment |
| CN111830270A (en) * | 2020-07-09 | 2020-10-27 | 迪瑞医疗科技股份有限公司 | Precise sample adding system, in-vitro diagnosis equipment and precise sample adding method |
| CN111830270B (en) * | 2020-07-09 | 2023-08-08 | 迪瑞医疗科技股份有限公司 | Precise sample adding system, in-vitro diagnosis equipment and precise sample adding method |
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| CN109374913B (en) | 2022-06-14 |
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