CN109363983A - A method of addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis - Google Patents
A method of addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis Download PDFInfo
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Abstract
The invention discloses a kind of methods that addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis, prepared each medical fluid is mixed and is fitted into the vial of sealing, tighten bottle cap, it is placed in boiling water after heat sterilization processing, it is mixed with apple total polyphenols concentrate, lemon microcapsules, ethyl alcohol, glycerol and pure water are added, antibacterial mouth rinse for removing halitosis is made in mixing.Oriental wormwood, wild chrysanthemum, honeysuckle, the root of Dahurain angelica, asarum bioactivity are strong, are proven to have the effects of anti-inflammatory, adjusting is immune, and inhibited to the various bacteria including oral cavity pathogen；Single medical fluid is extracted from oriental wormwood, wild chrysanthemum, honeysuckle, and extracts asarum and root of Dahurain angelica admixing medical solutions, prepares compound honeysuckle Chinese medicine mouth wash；Gum redness can effectively be mitigated, visit and examine the inflammatory reactions such as bleeding, promote periodontium healing.
Description
Technical field
The invention belongs to mouthwash technical fields, and in particular to a kind of addition lemon microcapsules allotment is antibacterial to be eliminated bad breath
The method of mouthwash.
Background technique
Mouthwash plays an important role in the prevention and adjuvant treatment of mouth disease.Not according to function and ingredient
Together, mouthwash can be divided into preventing decayed tooth class mouthwash, anti-sensitive kinds mouthwash, antibiotics mouthwash, inhibit plaque class mouthwash,
Breath freshening class mouthwash and Chinese herbal medicine class mouthwash, remove oral peculiar smell, anti-caries, in terms of have good effect
Fruit, frequently as the adjuvant drug of the diseases such as periodontitis, gingivitis, pericoronitis and canker sore.Wherein, plaque class is inhibited to gargle
The one kind of water as self bacterial plaque control means, the instruments such as toothbrush, dental floss, excavator can be entered by liquid flow forces to be arrived
The region reached supplements the deficiency of Mechanical plaque control methods.Currently, clinically in common mouthwash mostly containing antibiotic, iodine,
The ingredients such as ethyl alcohol, such as chlorohexidene, novel mouth wash containing iodine water are used for a long time and easily cause facing coloring, oral cavity flora imbalance, oral cavity
The problems such as mucosa irritation.Therefore, finding mouthwash effective, safe, alcohol-free, being used for a long time becomes the new of periodontosis prevention and treatment
Hot spot.
In China, the applicating history of natural drug is long and toxic side effect is small, and materials are convenient, economical and practical, and some, which also has, kills
Bacterium antiinflammation, thus it is widely used in basic research and clinical practice.The utilization of Chinese materia medica preparation in the oral cavity extensively, largely grinds and makes internal disorder or usurp
Show that Chinese medicine has good curative effect in the diseases such as treatment periodontosis, canker sore.But at present for the report of such Chinese medicine
The mostly effect of certain single Chinese herbal medicine, it is less to the research of Chinese medicine compound prescription, and Chinese medicine compound prescription can more embody differentiation of tcm
The characteristics of, give full play to the synergistic effect and traditional Chinese medicine plurality of active ingredients multiple target effect of drug.As people are to mouthwash
The advantage of the concern of safety, Chinese medicine class mouthwash gradually displays.Have the Chinese medicine class mouthwash of sale of finished goods on the market,
But the problems such as generally existing color is muddy, mouthfeel is poor or contains alcohol, so that its acceptance is low compared with other class mouthwashes.And it is right
It makes internal disorder or usurp in grinding for Chinese herbal medicine class mouthwash, the Xi Tong Yan Rong from basis to application is less, lacks the objective observation of curative effect of science, and right
It is less in its toxicity and Reporting of harms, fail to provide experimental basis to clinical application.Theory of traditional Chinese medical science thinks that stomach fire is red-hot, kidney
The deficiency of vital energy is lost and insufficiency of vital energy and blood is the Etiological of periodontitis.Oriental wormwood, wild chrysanthemum, honeysuckle, the root of Dahurain angelica, asarum bioactivity are strong, quilt
Confirmation has the effects that anti-inflammatory, adjusting is immune and inhibited to the various bacteria including oral cavity pathogen.By this
5 kinds of drugs carry out compound compatibility, applied to there is not been reported in prevention and treatment periodontal disease.
The bad smell that oral cavity generates when halitosis is breathing, the disease incidence of Chinese population halitosis is about 27% according to investigations.Halitosis
Generation it is related with bacteriogenic volatile sulfur compounds, Fusobacterium nucleatum porphyromonas gingivalis
For generally acknowledged halitosis pathogenic bacteria.Lemon has unique aromatic odor and significant bacteriostasis, in medical research
It is very concerned.Polyphenol in apple is the research hotspot of recent domestic, and has multi-efficiency, and product has very big
Development space.In order to make full use of wind shedding and the fruit thinning of apple, apple polyphenol product is researched and developed.
Summary of the invention
The purpose of the present invention is being directed to existing problem, it is antibacterial except mouth to provide a kind of addition lemon microcapsules allotment
The method of smelly mouthwash, the mouthwash according to this method production have excellent biocidal property, can achieve the effect that eliminate bad breath.
The present invention is achieved by the following technical solutions:
A method of addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis, which comprises the steps of:
(1) extraction of compound honeysuckle traditional Chinese medicine liquid:
1:20 is distinguished into each drug, distilled water immersion 20-25min is added, be condensed back and extract 5-6h, collect medical fluid and volatilization
Medical fluid is centrifuged 15-20min while hot by oil, retains supernatant；It will volatilize oil to mix with supernatant, 0.1-0.2 parts of citric acids be added
Sodium and 0.4-0.5 parts of Tween 80 hydrotropies mix, and concentration respectively obtains oriental wormwood, wild chrysanthemum, honeysuckle medical fluid and the root of Dahurain angelica and asarum
Admixing medical solutions are saved in 3-5 DEG C；
(2) spray drying prepares lemon microcapsules:
Gum arabic powder, beta-cyclodextrin 2:8 are mixed into obtain wall material, glycerin monostearate, sucrose fatty ester are mixed
Lemon and water 1:1 are mixed to obtain core material by composite emulsifier；Wall material, core material are mixed by core wall ratio 1:3, add compounding
Emulsifier, homogeneous 1-2min are spray-dried under the conditions of inlet air temperature is 170-175 DEG C, and it is 10-20% that solid concentration, which is made,
Lemon microcapsules；
(3) allotment of antibacterial mouth rinse for removing halitosis:
Each medical fluid of preparation gained in (1) is mixed and is fitted into the vial of sealing, bottle cap is tightened, is placed in boiling water and heats 30-
After 40min sterilization treatment, is mixed with gained lemon microcapsules in apple total polyphenols concentrate, (2), add ethyl alcohol, 5-
Antibacterial mouth rinse for removing halitosis is made in 10 parts of glycerol and pure water, mixing.
Further, each drug is respectively 40-50 portions of oriental wormwoods, 40-50 parts of wild chrysanthemums, 40-50 portions of honeysuckles in step (1)
With+33 parts of roots of Dahurain angelica of 17 parts of asarums.
Further, application distillation joint enzymatic method extracts lemon in step (2): citric acid being added into distilled water
Adjusting pH with sodium citrate is 5, adds cellulase and pectase mixing；The pericarp of 50-60 parts of Fresh Lemons is crushed
It after machine crushes, puts into deployed distilled water, seals, water bath processing 50-70min, is again heated at 36-38 DEG C
100 DEG C, slightly boiled distillation 25-35min is kept, collects volatile oil, sealing is saved in 3-5 DEG C；
Citric acid and sodium citrate mass ratio are 1:3, cellulase and pectase mass ratio are 2:1.
Further, the extraction of apple polyphenol is concentrated in step (3): by the cleaning of apple young fruit, cleaning moisture, 1- is added
2 parts of ascorbic acid, are crushed with pulverizer, 60% ethyl alcohol are added by solid-liquid ratio 1:15 in the apple crushed to 40-60 parts, in 50-60
Ultrasonic wave extraction 25-35min at DEG C, rotary evaporation concentration, obtains apple total polyphenols concentrate.
Further, concentration of alcohol is 5% in mouthwash in step (3), and polyphenol concentration is 10mg/mL.
The present invention has the advantage that compared with prior art
(1) oriental wormwood, wild chrysanthemum, honeysuckle, the root of Dahurain angelica, asarum bioactivity are strong, are proven to have the effects of anti-inflammatory, adjusting is immune,
And it is inhibited to the various bacteria including oral cavity pathogen；Simple is extracted from oriental wormwood, wild chrysanthemum, honeysuckle
Liquid, and asarum and root of Dahurain angelica admixing medical solutions are extracted, prepare compound honeysuckle Chinese medicine mouth wash；Gum redness can effectively be mitigated, visit and examine
The inflammatory reactions such as bleeding promote periodontium healing.
(2) application distillation joint enzymatic method extracts lemon, and lemon can inhibit Fusobacterium nucleatum, porphyromonas
The growth of monad and saliva Mixed Microbes is sticked, and the production gas value of Fusobacterium nucleatum, porphyromonas gingivalis is lowered, and adds lemon
The mouthwash of essential oil can improve halitosis patient sensory experience, lower patient's halitosis measured value；Height is produced using spray drying
The lemon microencapsulated product of quality, microcapsule product shape is rounded or oval, surface compact, flawless, size
Uniformly, with the fungistatic effect of slow release long-acting.
(3) it using apple young fruit as raw material, using ultrasonic wave extraction apple polyphenol, is added in mouthwash, to first sulphur
Ether, the elimination factor of hydrogen sulfide are high, and it is good to eliminate bad breath effect；Since apple polyphenol itself has powerful sterilizing function, so formula
Without preservative, it is nontoxic, stimulation it is small.
Specific embodiment
Embodiment 1
A method of addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis, which comprises the steps of:
(1) extraction of compound honeysuckle traditional Chinese medicine liquid:
1:20 is distinguished into each drug, distilled water immersion 20min is added, be condensed back and extract 5h, collect medical fluid and volatile oil, take advantage of
Medical fluid is centrifuged 15min by heat, retains supernatant；It will volatilize oil to mix with supernatant, 0.1 part of sodium citrate be added and 0.4 part is spat
Warm 80 hydrotropies, mix, and concentration respectively obtains oriental wormwood, wild chrysanthemum, honeysuckle medical fluid and the root of Dahurain angelica and asarum admixing medical solutions, in 3-5 DEG C
It saves；
(2) spray drying prepares lemon microcapsules:
Gum arabic powder, beta-cyclodextrin 2:8 are mixed into obtain wall material, glycerin monostearate, sucrose fatty ester are mixed
Lemon and water 1:1 are mixed to obtain core material by composite emulsifier；Wall material, core material are mixed by core wall ratio 1:3, add compounding
Emulsifier, homogeneous 1min are spray-dried under the conditions of inlet air temperature is 170-175 DEG C, and the lemon that solid concentration is 10% is made
Essential oil microcapsules；
(3) allotment of antibacterial mouth rinse for removing halitosis:
Each medical fluid of preparation gained in (1) is mixed and is fitted into the vial of sealing, bottle cap is tightened, is placed in boiling water and heats 30min
After sterilization treatment, is mixed with gained lemon microcapsules in apple total polyphenols concentrate, (2), add ethyl alcohol, 5 parts of glycerol
And antibacterial mouth rinse for removing halitosis is made in pure water, mixing.
Further, each drug is respectively that 40 portions of oriental wormwoods, 40 parts of wild chrysanthemums, 40 portions of honeysuckles and 17 parts are thin in step (1)
Pungent+33 parts of roots of Dahurain angelica.
Further, application distillation joint enzymatic method extracts lemon in step (2): citric acid being added into distilled water
Adjusting pH with sodium citrate is 5, adds cellulase and pectase mixing；By the pericarp of 50 parts of Fresh Lemons crushing machine
It after crushing, puts into deployed distilled water, seals, the water bath processing 50min at 36-38 DEG C, be again heated to 100 DEG C, protect
Slightly boiled distillation 25min is held, volatile oil is collected, sealing is saved in 3-5 DEG C；
Citric acid and sodium citrate mass ratio are 1:3, cellulase and pectase mass ratio are 2:1.
Further, the extraction of apple polyphenol is concentrated in step (3): by the cleaning of apple young fruit, cleaning moisture, is added 1
Part ascorbic acid, is crushed with pulverizer, 60% ethyl alcohol is added by solid-liquid ratio 1:15 in the apple crushed to 40 parts, at 50-60 DEG C
Ultrasonic wave extraction 25min, rotary evaporation concentration, obtains apple total polyphenols concentrate.
Further, concentration of alcohol is 5% in mouthwash in step (3), and polyphenol concentration is 10mg/mL.
Embodiment 2
A method of addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis, which comprises the steps of:
(1) extraction of compound honeysuckle traditional Chinese medicine liquid:
1:20 is distinguished into each drug, distilled water immersion 25min is added, be condensed back and extract 6h, collect medical fluid and volatile oil, take advantage of
Medical fluid is centrifuged 20min by heat, retains supernatant；It will volatilize oil to mix with supernatant, 0.2 part of sodium citrate be added and 0.5 part is spat
Warm 80 hydrotropies, mix, and concentration respectively obtains oriental wormwood, wild chrysanthemum, honeysuckle medical fluid and the root of Dahurain angelica+asarum admixing medical solutions, in 3-5 DEG C
It saves；
(2) spray drying prepares lemon microcapsules:
Gum arabic powder, beta-cyclodextrin 2:8 are mixed into obtain wall material, glycerin monostearate, sucrose fatty ester are mixed
Lemon and water 1:1 are mixed to obtain core material by composite emulsifier；Wall material, core material are mixed by core wall ratio 1:3, add compounding
Emulsifier, homogeneous 2min are spray-dried under the conditions of inlet air temperature is 170-175 DEG C, and the lemon that solid concentration is 20% is made
Essential oil microcapsules；
(3) allotment of antibacterial mouth rinse for removing halitosis:
Each medical fluid of preparation gained in (1) is mixed and is fitted into the vial of sealing, bottle cap is tightened, is placed in boiling water and heats 40min
After sterilization treatment, is mixed with gained lemon microcapsules in apple total polyphenols concentrate, (2), add ethyl alcohol, 10 parts of glycerol
And antibacterial mouth rinse for removing halitosis is made in pure water, mixing.
Further, each drug is respectively that 50 portions of oriental wormwoods, 50 parts of wild chrysanthemums, 50 portions of honeysuckles and 17 parts are thin in step (1)
Pungent+33 parts of roots of Dahurain angelica.
Further, application distillation joint enzymatic method extracts lemon in step (2): citric acid being added into distilled water
Adjusting pH with sodium citrate is 5, adds cellulase and pectase mixing；By the pericarp of 60 parts of Fresh Lemons crushing machine
It after crushing, puts into deployed distilled water, seals, the water bath processing 70min at 36-38 DEG C, be again heated to 100 DEG C, protect
Slightly boiled distillation 35min is held, volatile oil is collected, sealing is saved in 3-5 DEG C；
Citric acid and sodium citrate mass ratio are 1:3, cellulase and pectase mass ratio are 2:1.
Further, the extraction of apple polyphenol is concentrated in step (3): by the cleaning of apple young fruit, cleaning moisture, is added 2
Part ascorbic acid, is crushed with pulverizer, 60% ethyl alcohol is added by solid-liquid ratio 1:15 in the apple crushed to 60 parts, at 50-60 DEG C
Ultrasonic wave extraction 35min, rotary evaporation concentration, obtains apple total polyphenols concentrate.
Further, concentration of alcohol is 5% in mouthwash in step (3), and polyphenol concentration is 10mg/mL.
There is excellent bacteriostasis property according to the mouthwash of the method for the present invention production, the fungistatic effect with slow release long-acting.
It can achieve the effect that eliminate bad breath.
Claims (5)
1. a kind of method that addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis, which is characterized in that including walking as follows
It is rapid:
(1) extraction of compound honeysuckle traditional Chinese medicine liquid:
1:20 is distinguished into each drug, distilled water immersion 20-25min is added, be condensed back and extract 5-6h, collect medical fluid and volatilization
Medical fluid is centrifuged 15-20min while hot by oil, retains supernatant；It will volatilize oil to mix with supernatant, 0.1-0.2 parts of citric acids be added
Sodium and 0.4-0.5 parts of Tween 80 hydrotropies mix, and concentration respectively obtains oriental wormwood, wild chrysanthemum, honeysuckle medical fluid and the root of Dahurain angelica and asarum
Admixing medical solutions are saved in 3-5 DEG C；
(2) spray drying prepares lemon microcapsules:
Gum arabic powder, beta-cyclodextrin 2:8 are mixed into obtain wall material, glycerin monostearate, sucrose fatty ester are mixed
Lemon and water 1:1 are mixed to obtain core material by composite emulsifier；Wall material, core material are mixed by core wall ratio 1:3, add compounding
Emulsifier, homogeneous 1-2min are spray-dried under the conditions of inlet air temperature is 170-175 DEG C, and it is 10-20% that solid concentration, which is made,
Lemon microcapsules；
(3) allotment of antibacterial mouth rinse for removing halitosis:
Each medical fluid of preparation gained in (1) is mixed and is fitted into the vial of sealing, bottle cap is tightened, is placed in boiling water and heats 30-
After 40min sterilization treatment, is mixed with gained lemon microcapsules in apple total polyphenols concentrate, (2), add ethyl alcohol, 5-
Antibacterial mouth rinse for removing halitosis is made in 10 parts of glycerol and pure water, mixing.
2. a kind of method that addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis according to claim 1,
It is characterized in that, each drug is respectively that 40-50 portions of oriental wormwoods, 40-50 parts of wild chrysanthemums, 40-50 portions of honeysuckles and 17 parts are thin in step (1)
Pungent+33 parts of roots of Dahurain angelica.
3. a kind of method that addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis according to claim 1,
It is characterized in that, application distillation joint enzymatic method extracts lemon in step (2): citric acid and citric acid being added into distilled water
It is 5 that sodium, which adjusts pH, adds cellulase and pectase mixing；The pericarp of 50-60 parts of Fresh Lemons is crushed with machine is crushed
Afterwards, it puts into deployed distilled water, seals, the water bath processing 50-70min at 36-38 DEG C, be again heated to 100 DEG C, keep
Slightly boiled distillation 25-35min, collects volatile oil, and sealing is saved in 3-5 DEG C；
Citric acid and sodium citrate mass ratio are 1:3, cellulase and pectase mass ratio are 2:1.
4. a kind of method that addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis according to claim 1,
It is characterized in that, the extraction concentration of apple polyphenol in step (3): by the cleaning of apple young fruit, cleans moisture, 1-2 parts of addition is anti-bad
Hematic acid is crushed with pulverizer, and 60% ethyl alcohol is added by solid-liquid ratio 1:15 in the apple crushed to 40-60 parts, surpasses at 50-60 DEG C
Sound wave extracts 25-35min, and rotary evaporation concentration obtains apple total polyphenols concentrate.
5. a kind of method that addition lemon microcapsules deploy antibacterial mouth rinse for removing halitosis according to claim 1,
It is characterized in that, concentration of alcohol is 5% in mouthwash in step (3), and polyphenol concentration is 10mg/mL.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112754966A (en) * | 2021-01-28 | 2021-05-07 | 陕西师范大学 | Apple polyphenol halitosis-removing mouth wash and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112754966A (en) * | 2021-01-28 | 2021-05-07 | 陕西师范大学 | Apple polyphenol halitosis-removing mouth wash and preparation method thereof |
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