CN109324040A - A kind of hydrogen peroxide plasma sterilizing indicating means - Google Patents
A kind of hydrogen peroxide plasma sterilizing indicating means Download PDFInfo
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- CN109324040A CN109324040A CN201811006101.4A CN201811006101A CN109324040A CN 109324040 A CN109324040 A CN 109324040A CN 201811006101 A CN201811006101 A CN 201811006101A CN 109324040 A CN109324040 A CN 109324040A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/14—Plasma, i.e. ionised gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
- A61L2/28—Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/775—Indicator and selective membrane
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Abstract
This patent is related to plasma sterilization instruction field, disclose a kind of hydrogen peroxide plasma sterilizing indicating means, it is characterized in that, it will coat in sterilizing object or its outer packing or printing sterilisation indicator or carry out hydrogen peroxide plasma sterilization treatment again after pasting the Indicator Paper containing sterilisation indicator, and then by observation indication coating or indicate that the color change of printing layer or Indicator Paper judge whether sterilizing object passes through effective sterilization treatment；Wherein, the indicator includes at least more than one can generate the dyestuff and a kind of pyridine derivate that tint retention is played in indicator system of color transition under hydrogen peroxide plasma effect.The mating reaction in hydrogen peroxide plasma environment of pyridine derivate and dyestuff, promote dyestuff that apparent color change occurs afterwards before sterilization, and the color after sterilizing does not return to original color, color stability is excellent, can reliably differentiate whether sterilizing object passes through sterilization process.
Description
Technical field
This patent is related to plasma sterilization instruction field, sterilizes more particularly, to a kind of hydrogen peroxide plasma
Indicating means.
Background technique
With the rapid development of medical and health care system and the continuous improvement of medical technology, various sensitive instrument and equipments by by
Step promotes and applies, and these equipment not can be carried out high-temperature sterilization generally (mainly high temperature and high pressure steam, high temperature are xeothermic).To understand
Certainly this problem, various cryochemistry sterilizing methods also gradually generate, and the ring of hospital's sterilizing is such as applied to the 1950s
Oxidative ethane low temperature sterilization, to mid-term the 1990s, ethylene oxide sterilizer is by the U.S. and some big cities of China
Hospital is widely used.Ethylene oxide all has killing effect to the various microorganisms such as bacterium, gemma, fungi and virus；It goes out
Bacterium mechanism is combined with amino, hydroxyl, carboxyl or the sulfydryl in bacterio protein molecule, enzyme, nucleic acid, is generated to somatic cells
Destruction, to reach sterilization functions.However, ethylene oxide is toxic, it is suspecious carcinogen, in addition to extremely stringent room air concentration
Control, also needs cumbersome purification emission treatment, the operation cycle is longer；What another kind was widely used is exactly that low-temperature formaldehyde vapor goes out
Bacterium, Bactericidal Mechanism is similar to ethylene oxide, equally exists gas is toxic, need are stringent concentration control and purified treatment, sterilizing
The defects of operation cycle is long.
In the 1990s, plasma sterilization cold sterilization techniques new as one start to interview.Plasma is
What gas generated under heating or strong-electromagnetic field effect, mainly by electronics, ion, atom, molecule, living radical and ray etc.
Composition, that is, be referred to as " gas slurry " material aggregation state.Existing plasma sterilization mainly utilizes hydrogen peroxide (H2O2) be excited into
" gas slurry " sterilizes, hydrogen peroxide (H2O2) it is active oxidant, decomposition product is water and nascent oxygen.Hydrogen peroxide etc. from
The Bactericidal Mechanism of daughter is mainly caused by ultraviolet light, high energy particle and living radical comprehensive function, wherein living radical
Hydrogen peroxide-based, hydroxyl isoreactivity substance destroy its metabolism in conjunction with the intracorporal protein of bacterium and nucleic acid, to rise
It is acted on to sterilization.The characteristics of hydrogen peroxide low-temperature plasma disinfection system: sterilizing speed is fast, only needs 55 minutes or so,
Woth no need to the time of detoxifying；Not residual toxicity substance, final decomposition product are water and oxygen to environment and medical worker's safety.Therefore,
Sterilization of the hydrogen peroxide low-temperature plasma disinfection system (joining GB/T32309-2015 in detail) in addition to can be used for medical instrument
Outside, also it is used for industry and work that hygienic material, food and tableware etc. need sterilization.
Need whether the equipment to sterilize have passed through sterilization process it is of importance that differentiating during the utilization of these sterilizations,
Check whether the sterilization effect for acting on equipment is appropriate.In this regard, the indicator group of tone variations occurs because of sterilisation process
Close object have become whether the differentiation means or sterilization effect detection methods whether appropriate Jing Guo sterilization treatment.
It is existing various for showing that director composition existing for hydrogen peroxide is all based on the principle of acid-base titration.Acid
Neutralization indicator respectively has a different pKa values, therefore indicate color with different soda acids, these acid-base indicators are just like methyl
Purple, picric acid, methyl green, peacock green, cresol red, crystal violet, thymol blue, crystal violet, alizarin yellow R, dimethyl yellow, bromine phenol
Blue, Congo red, alizarin red, bromocresol green, methyl red, dibromophenolphthalein, bromocresol purple, bromthymol blue, dimethyl diaminophenazine chloride, phenol red, cresols
Red, phenolphthalein, thymolphthalein, alizarin red S, alizarin yellow R, titan yellow etc..By the way that the acid-base indicator being applicable in is cooperated some iodate
Object, metal salt, transition metal salt etc., for applicable aqueous polymer solution with hydrogen sulfide is given, sodium hypochlorite etc. is impregnated in filter test paper；
Hydrogen peroxide forms plasma in sterilizer under high-frequency electromagnetic field action, have free radical HO in plasma, cross hydroxyl freedom
Base HO2, excitation state H2O2, active oxygen atom O, the active hydrogen atom H isoreactivity factor react effect and generate color change, because
This prepared test paper can detect hydrogen peroxide.Equally based on this chemical action, there are also answered with the product for printing ink pattern
In hydrogen peroxide low-temperature plasma disinfection system, but that there are various kinds before and after use is unstable for indicant finished product, such as
For product because outside air contact with moisture object acid-base material influences, storage for a long time causes the variation of indicator to distinguish unobvious or warp
There is colour fading etc. during file record after disinfection system processing, these can all affect the daily management at hospital supplies center.
Summary of the invention
In view of this, this patent is to overcome at least one described in the above-mentioned prior art insufficient, a kind of peroxide is provided
Change hydrogen plasma sterilize indicating means, solve dyestuff it is non-discolouring in hydrogen peroxide plasma or discoloration after cannot for a long time
The problem of stablizing fixation.
In order to solve above-mentioned technical problem, this patent is adopted the following technical solutions:
A kind of hydrogen peroxide plasma sterilizing indicating means, which is characterized in that coated in will sterilize object or its outer packing
Or it is carried out at hydrogen peroxide plasma sterilizing again after the Indicator Paper of printing sterilisation indicator or stickup containing sterilisation indicator
Then reason judges whether sterilizing object passes through by observation indication coating or instruction printing layer or the color change of Indicator Paper
Effective sterilization treatment；Wherein, the indicator includes at least more than one and can generate under hydrogen peroxide plasma effect
The dyestuff of color transition and a kind of pyridine derivate that tint retention is played in indicator system.
Dyestuff used in hydrogen peroxide plasma sterilisation indicator and eo sterilization indicator is basic
It is identical.But due to the Bactericidal Mechanism of the two difference, ethylene oxide gas is to be killed by alkylation to thallus, and peroxidating
Hydrogen plasma is to aoxidize to kill thallus by stronger (radio frequency-ion), and therefore, the two does not make the mechanism of dye discoloration also not
Together, ethylene oxide gas and dyestuff can stably generate after acting on or regression is at another color；And hydrogen peroxide plasma
After generating in sterilizer, even if having the hydrogen peroxide of strong oxidation and dyestuff to act on, also will appear indicator cannot become
Color can change colour but unstable or the case where cannot change colour after a long time placement.For this purpose, pyridine derivate is used for by the present invention
Gas ions sterilizing instruction in dyestuff mating reaction, as the dye to have changed colour generated in hydrogen peroxide plasmon sterilization treatment
The preventing agent of fading of material occurs that discoloration more steadily.
Further, the pyridine derivate is pyridone or one of pyrithione or pyrithione or a variety of.
Further, the pyrithione be copper pyrithione, zinc pyrithione, sodium pyrithione, pyrithione magnesium,
Pyrithione cadmium, pyrithione zirconium etc. it is one or more.Reducing dye, sulphur vat dye are in [O], [H] ion radical
Under the action of apparent color transition can occur, based on the preferred reducing dye of dyestuff, sulphur vat dye described in this this patent
At least one of, these dyestuffs can be reduced into soluble leuco compound sodium salt, most of leuco compound sodium in alkaline solution
Salt color is shallower or colourless (also having part just opposite), these leuco compound sodium salts are under air or other oxidizing effects
Original color can be changed into.As some indigo reduction leuco dyes be it is colourless, but be oxidized reduction after be then skipper；Such as
It is light yellow that anthraquinone reduction leuco dye, which is after red is oxidized reduction,.Though other dyestuffs also it is coloured transformation color difference ratio
Not upper reducing dye, sulphur vat dye；Apparent front and back color difference can preferably play indicative function.
The pyridine derivate is preferably with the pyridine derivate of ionizing group.Reducing dye, sulphur vat dye sheet are insoluble
In water-based system, though its procrypsis physical efficiency is dissolved in water-based system, non-aqueous solution can be generated again as system pH value declines, and is introduced
Copper pyrithione, sodium, zinc with ionizing group can stabilising system, while again play the role of improve plasma sensitivity.
The reducing dye includes at least one of Anthraquinones reducing dye, indigoids class reducing dye.
Anthraquinones reducing dye is with the reducing dye of anthraquinone or derivatives thereof synthesis and with the dyestuff of anthraquinone ring.This
The most of more unreduced color of the procrypsis acid sodium-salt of class dyestuff is that deeply, only only a few and unreduced color are approximate, this
It is since the anthraquinone of conjugated double bond does not produce the reason of coherent conjugated double bond after being reduced into procrypsis acid sodium-salt originally.
Its chemical principle are as follows:
The chemical principle of indigoids class reducing dye are as follows:
The reducing dye includes vat yellow WG, vat orange 6RTK, vat yellow FFRK, Reinstate rate, RSN, Vat Blue BC,
Vat blue GCDN, vat blue 3G, 5G, vat green BB, reducing yellow G, vat golden orange, Threne dark blue OB, Threne dark blue RB, vat black
BB, vat brilliant green B, FFB, purple R, brilliant violet 3B, brilliant violet RR, purplish red RRK, reducing yellow G C, bright green FFB, No. 1 indigo, vat blue
2B, vat red 5B, pink R, vat brown RRD, purple RH, RRN, pink FFB, scarlet B, reduction purple BBF, reduction scarlet R, reduction
At least one of black B, golden yellow GK, the bright orange GK of reduction, brilliant blue 4G.
The sulphur vat dye include SULPHUR YELLOW 2 G, the gorgeous indigo plant CLB of vulcanization, sulfur blue RN, BN, BRN, vulcanize Xinlan BBF,
Sulphur dark-blue 3R, RL, sulphur red brown 3B, sulphur black BN, reversion indigo plant R, the black CLN of reversion, sulphur yellow brown, sulphur red brown
Deng.
Plasma sterilization indicator of the present invention further includes at least one applicable aqueous polymer resin link stuff.
Selected by the present invention be applicable in aqueous polymer resin link stuff have cellulose derivative, aqueous polybutadiene,
Aqueous epoxy resins, aqueous alkide resin, aqueous polyester resin, waterborne polyurethane resin, water-and acrylate lotion etc..It is described
Cellulose derivative includes hydroxymethyl cellulose (CMC), methylcellulose (MC), hydroxyethyl cellulose (HEC), hydroxyethyl methyl
At least one of cellulose (HEMC), hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC).
The aqueous polyurethane emulsion of the preferably one or two kinds of different models of the present invention and another or two kinds of different models
Water-and acrylate lotion carries out composite usage.
Plasma sterilization indicator of the present invention further includes defoaming agent, glidant, filler, pigment, plasticizer, surface
It is activating agent, wetting dispersing agent, thickener, coalescing agent, one or more in surfactant.The filler include titanium dioxide,
Lithopone, zinc oxide it is one or more.
The stock that indicator is applicable in is various non-absorbent materials, such as PVC, PP, PET synthesize paper wood.
This patent has the advantages that compared with prior art:
In the indicator that hydrogen peroxide plasma sterilizing indicating means of the present invention uses, pyridine derivate and dyestuff
The mating reaction in hydrogen peroxide plasma environment promotes dyestuff that apparent color change occurs afterwards before sterilization, and passes through
Color after sterilizing does not return to original color, and color stability is excellent, whether can reliably differentiate sterilizing object
By sterilization process；Pyridine derivate can control the speed that dyestuff changes colour in hydrogen peroxide plasma, it is thus possible to logical
The variation of overtone judges whether sterilising conditions suffered by sterilizing object are appropriate.
Specific embodiment
The application of pyridine derivate of the invention in plasma sterilization instruction needs and dyestuff cooperates, and dyestuff is
The main body of color change is generated, pyridine derivate is the key substance for promoting dye discoloration and promoting discoloration stability, is tied below
Specific embodiment is closed to be described in further details this patent.
A kind of hydrogen peroxide plasma sterilizing indicating means, which is characterized in that will sterilize in object or its outer packing
Hydrogen peroxide plasma is carried out again after coating or printing sterilisation indicator or Indicator Paper of the stickup containing sterilisation indicator to go out
Then whether bacterium processing judges sterilizing object by observation indication coating or instruction printing layer or the color change of Indicator Paper
By effective sterilization treatment；Wherein, the sterilisation indicator includes at least more than one and can make in hydrogen peroxide plasma
With the lower dyestuff for generating color transition and a kind of pyridine derivate for playing tint retention in indicator system.
Embodiment 1
Sterilisation indicator includes each component of following parts by weight in the present embodiment,
Dyestuff: 5 parts of active red B, OB dyestuff are 0.5 part blue；
Pyridine derivate: 2 parts of sodium pyrithione；
Aqueous polymer resin link stuff: 30 parts of polyaminoester emulsion, 30 parts of acrylic emulsion；
Auxiliary agent: 2 parts of nanometer titanium dioxide, 0.5 part of rheological agent, 0.7 part of film forming agent, 0.1 part of defoaming agent, 10 parts of thickener；
Solvent: 19.2 parts of deionized water/alcohol.
Embodiment 2
Sterilisation indicator includes each component of following parts by weight in the present embodiment,
Dyestuff: 2.4 parts of reactive blue BF4R, pink 2 parts of R3L of dispersion；
Pyridine derivate: 2 parts of sodium pyrithione；
Aqueous polymer resin link stuff: 40 parts of polyaminoester emulsion, 20 parts of acrylic emulsion；
Auxiliary agent: 3 parts of nanometer titanium dioxide, 0.3 part of rheological agent, 0.7 part of film forming agent, 0.4 part of defoaming agent, 10 parts of thickener；
Solvent: 19.2 parts of deionized water/alcohol.
Embodiment 3
Sterilisation indicator includes each component of following parts by weight in the present embodiment,
Dyestuff: 1 part of Reactive Violet 5 R, 0.5 part of reducing yellow G；
Pyridine derivate: 1 part of zinc pyrithione, 1 part of pyrithione barium；
Aqueous polymer resin link stuff: 35 parts of polyaminoester emulsion, 35 parts of acrylic emulsion；
Auxiliary agent: 3 parts of nanometer titanium dioxide, 0.2 part of rheological agent, 1.0 parts of film forming agent, 0.3 part of defoaming agent, 10 parts of thickener；
Solvent: 12.5 parts of deionized water/alcohol.
Embodiment 4
Sterilisation indicator includes each component of following parts by weight in the present embodiment,
Dyestuff: 0.4 part of vat black B, 1.0 parts of Reactive Violet 5 R, 0.1 part of disperse blue RRL, 0.2 part of reducing yellow G；
Pyridine derivate: 1 part of sodium pyrithione, 1 part of copper pyrithione；
Aqueous polymer resin link stuff: 40 parts of polyaminoester emulsion, 30 parts of acrylic emulsion；
Auxiliary agent: 5 parts of nanometer titanium dioxide, 0.2 part of rheological agent, 0.8 part of film forming agent, 0.2 part of defoaming agent, 10 parts of thickener；
Solvent: 10.1 parts of deionized water/alcohol.
Embodiment 5
Sterilisation indicator includes each component of following parts by weight in the present embodiment,
Dyestuff: 3.5 parts of Reinstate rate；
Pyridine derivate: 2 parts of sodium pyrithione；
Aqueous polymer resin link stuff: 30 parts of polyaminoester emulsion, 30 parts of acrylic emulsion；
Auxiliary agent: 4 parts of nanometer titanium dioxide, 0.5 part of rheological agent, 0.7 part of film forming agent, 0.1 part of defoaming agent, 10 parts of thickener；
Solvent: 19.2 parts of deionized water/alcohol.
Embodiment 6
Sterilisation indicator includes each component of following parts by weight in the present embodiment,
Dyestuff: 4.4 parts of vat yellow WG；
Pyridine derivate: 2 parts of sodium pyrithione；
Aqueous polymer resin link stuff: 40 parts of polyaminoester emulsion, 20 parts of acrylic emulsion；
Auxiliary agent: 3 parts of nanometer titanium dioxide, 0.3 part of rheological agent, 0.7 part of film forming agent, 0.4 part of defoaming agent, 10 parts of thickener；
Solvent: 19.2 parts of deionized water/alcohol.
Embodiment 7
Sterilisation indicator includes each component of following parts by weight in the present embodiment,
Dyestuff: reversion is 2 parts indigo, disperses pink 0.5 part；
Pyridine derivate: 1.5 parts of sodium pyrithione；
Aqueous polymer resin link stuff: 35 parts of polyaminoester emulsion, 35 parts of acrylic emulsion；
Auxiliary agent: 2 parts of nanometer titanium dioxide, 0.2 part of rheological agent, 1.0 parts of film forming agent, 0.3 part of defoaming agent, 10 parts of thickener；
Solvent: 10.1 parts of deionized water/alcohol.
Embodiment 8
Sterilisation indicator includes each component of following parts by weight in the present embodiment,
Dyestuff: 1.5 parts of reversion Huang 2G, OB dyestuff are 0.2 part blue
Pyridine derivate: 1.5 parts of sodium pyrithione, 0.5 part of pyrithione cadmium；
Aqueous polymer resin link stuff: 40 parts of polyaminoester emulsion, 30 parts of acrylic emulsion；
Auxiliary agent: 5 parts of nanometer titanium dioxide, 0.2 part of rheological agent, 0.8 part of film forming agent, 0.2 part of defoaming agent, 10 parts of thickener；
Solvent: 10.1 parts of deionized water/alcohol.
Embodiment 9
The present embodiment and the difference of embodiment 5 are that aqueous polymer resin link stuff includes 60 parts of aqueous polybutadiene,
Other are the same as embodiment 5.
Embodiment 10
The present embodiment and the difference of embodiment 6 are that aqueous polymer resin link stuff includes 60 parts of aqueous epoxy resins, other
With embodiment 6.
Comparative example 1
This comparative example the difference from embodiment 1 is that, do not include pyridine derivate in sterilisation indicator, other are the same as embodiment 1.
Comparative example 2
The difference of this comparative example and embodiment 6 is, does not include pyridine derivate in sterilisation indicator, other are the same as embodiment 6.
Test method:
1, by the plasma sterilization indicator of the various embodiments described above and comparative example respectively in PP type synthetic paper
On the substrate of (YupoCorporation corporation Yupo FGS-250), hand is carried out with the ring bar type wet film applicator of 0.45m/m
Work coating, is made corresponding Indicator Paper, and the priming color of each Indicator Paper is recorded in table 1.
2, sterilization treatment is carried out with the plasma sterilizer (LK/DZK) of Chengdu Lao Ken medical science and technology limited liability company
(2 minutes Processing for removing and short circular treatment), and color change results are recorded in table 1.Wherein, 2 minutes Processing for removing refer to
Sterilizing chamber is decompressed to about 0.5torr, high-frequency energy is assigned under the state into sterilizing chamber and manufactures air plasma state, it is extensive
After a multiple pressure, after being decompressed to about 0.4torr once again, injection hydrogen peroxide is allowed to spread processing in 2 minutes；Short circular treatment
Refer to then " 2 minutes Processing for removing ", it is a little to depressurize after spreading hydrogen peroxide 6 minutes, it then assigns high-frequency energy and manufactured
After the low temperature plasma state of hydrogen oxide, hydrogen peroxide is further injected into, spreads 8 minutes, assigns the processing of high-frequency energy.
3, each Indicator Paper Jing Guo hydrogen peroxide plasma sterilization treatment is placed in the constant temperature and humidity of 23 DEG C, 90%RH
In slot after 1 month, color change is recorded in table 1.
1 test result of table
According to 1 test result of table it is found that apparent face all has occurred in plasma sterilization in above embodiments before and after the processing
Color transformation, and the color after transformation can steadily exist.From the test of embodiment 1 and comparative example 1, embodiment 6 and comparative example 2
As a result it is found that pyridine derivate plays key effect in plasma sterilization instruction, in embodiment 1, pyridine derivate is
Whether indicator the key factor of color transition, in embodiment 6, pyridine derivate occur in plasma sterilization before and after the processing
Influence the color difference that color transition occurs before and after the processing in plasma sterilization for indicator；From embodiment 5 and embodiment 9, embodiment 6
It can be seen that polyaminoester emulsion with the test result of embodiment 10 and acrylic acid ester emulsion compound and compares other waterborne polymerics tool
There is apparent advantage, it is more excellent to a variety of non-hygroscopic substrate adhesive force, it is compatible to illuminating colour/reducing dye preferable, at sterilizing
Color development is without darker shade after reason.
Obviously, above-described embodiment of this patent is only intended to clearly illustrate this patent example, and is not pair
The restriction of the embodiment of this patent.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all this
Made any modifications, equivalent replacements, and improvements etc., should be included in patent claims within the spirit and principle of patent
Protection scope within.
Claims (10)
- The indicating means 1. a kind of hydrogen peroxide plasma sterilizes, which is characterized in that will be applied in sterilizing object or its outer packing It covers or prints sterilisation indicator or carry out hydrogen peroxide plasma sterilizing again after pasting the Indicator Paper containing sterilisation indicator Then processing judges whether sterilizing object passes through by observation indication coating or instruction printing layer or the color change of Indicator Paper Cross effective sterilization treatment；Wherein, the indicator includes at least more than one and can produce under hydrogen peroxide plasma effect The dyestuff of raw color transition and a kind of pyridine derivate that tint retention is played in indicator system.
- The indicating means 2. hydrogen peroxide plasma according to claim 1 sterilizes, which is characterized in that described pyridine derived Object is pyridone or one of pyrithione or pyrithione or a variety of.
- The indicating means 3. hydrogen peroxide plasma according to claim 2 sterilizes, which is characterized in that the pyrithione One of copper, zinc pyrithione, sodium pyrithione, pyrithione magnesium, pyrithione cadmium, pyrithione zirconium are a variety of.
- The indicating means 4. hydrogen peroxide plasma according to claim 1 sterilizes, which is characterized in that the dyestuff includes At least one of reducing dye, sulphur vat dye.
- The indicating means 5. hydrogen peroxide plasma according to claim 4 sterilizes, which is characterized in that described pyridine derived Object is the pyridine derivate with ionizing group.
- The indicating means 6. hydrogen peroxide plasma according to claim 1 sterilizes, which is characterized in that the indicator is also Including aqueous polymer resin link stuff and auxiliary agent.
- The indicating means 7. hydrogen peroxide plasma according to claim 6 sterilizes, which is characterized in that the polymerizable aqueous Resin link stuff includes cellulose derivative, aqueous polybutadiene, aqueous epoxy resins, aqueous alkide resin, aqueous It is polyester resin, waterborne polyurethane resin, one or more in water-and acrylate lotion.
- The indicating means 8. hydrogen peroxide plasma according to claim 7 sterilizes, which is characterized in that the cellulose spreads out Biology includes hydroxymethyl cellulose (CMC), methylcellulose (MC), hydroxyethyl cellulose (HEC), hydroxyethylmethylcellulose (HEMC), at least one of hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC).
- The indicating means 9. hydrogen peroxide plasma according to claim 6 sterilizes, which is characterized in that the polymerizable aqueous Resin link stuff is formed by one or two kinds of aqueous polyurethane emulsions and one or two kinds of water-and acrylate latex composite compoundings.
- The indicating means 10. hydrogen peroxide plasma according to claim 6 sterilizes, which is characterized in that the auxiliary agent packet Include defoaming agent, glidant, filler, pigment, plasticizer, surfactant, wetting dispersing agent, thickener, coalescing agent, surface work It is one or more in property agent；The filler includes one of titanium dioxide, lithopone, zinc oxide or a variety of.
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| CN201811006101.4A CN109324040A (en) | 2018-08-30 | 2018-08-30 | A kind of hydrogen peroxide plasma sterilizing indicating means |
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| CN201811006101.4A CN109324040A (en) | 2018-08-30 | 2018-08-30 | A kind of hydrogen peroxide plasma sterilizing indicating means |
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| CN110938329A (en) * | 2019-12-23 | 2020-03-31 | 深圳市安达医疗感控科技有限公司 | Hydrogen peroxide low-temperature plasma sterilization indicating ink |
| CN113767276A (en) * | 2019-04-26 | 2021-12-07 | 3M创新有限公司 | Chemical hydrogen peroxide indicator |
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| CN115403120A (en) * | 2021-05-27 | 2022-11-29 | 厦门大学 | Biological safety waste liquid collecting and treating system and method |
| CN117783103A (en) * | 2023-12-28 | 2024-03-29 | 无锡嘉润诊断技术有限公司 | High-sensitivity calcium qualitative detection test strip and manufacturing method thereof |
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| CN117783103A (en) * | 2023-12-28 | 2024-03-29 | 无锡嘉润诊断技术有限公司 | High-sensitivity calcium qualitative detection test strip and manufacturing method thereof |
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