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CN109224164B - Membrane oxygenator integrated with centrifugal pump - Google Patents

Membrane oxygenator integrated with centrifugal pump Download PDF

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Publication number
CN109224164B
CN109224164B CN201811417334.3A CN201811417334A CN109224164B CN 109224164 B CN109224164 B CN 109224164B CN 201811417334 A CN201811417334 A CN 201811417334A CN 109224164 B CN109224164 B CN 109224164B
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China
Prior art keywords
blood
shell
mandrel
blood inlet
centrifugal pump
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Application number
CN201811417334.3A
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Chinese (zh)
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CN109224164A (en
Inventor
魏旭峰
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Suzhou Xiaoshuai Medical Equipment Co ltd
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Suzhou Xiaoshuai Medical Equipment Co ltd
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Priority to CN201811417334.3A priority Critical patent/CN109224164B/en
Publication of CN109224164A publication Critical patent/CN109224164A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621Constructional aspects thereof
    • A61M1/1623Disposition or location of membranes relative to fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698Blood oxygenators with or without heat-exchangers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3666Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10Location thereof with respect to the patient's body
    • A61M60/104Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A61M60/113Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20Type thereof
    • A61M60/205Non-positive displacement blood pumps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/04Liquids
    • A61M2202/0413Blood

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Mechanical Engineering (AREA)
  • External Artificial Organs (AREA)

Abstract

The invention discloses a membrane oxygenator integrated with a centrifugal pump, which comprises a centrifugal pump system and a gas exchange device; the centrifugal pump system is fixedly arranged below the gas exchange device; the membrane oxygenator also comprises a blood inlet nozzle, a bleeding nozzle, an air inlet nozzle and an exhaust nozzle; the membrane oxygenator integrated with the centrifugal pump provided by the invention is small in size, convenient to carry and transport, and suitable for first aid, operation in a hospital and transportation in the hospital; the connection and the use are convenient, the operation is quicker, the time is saved, and the in vitro life treatment can be started more quickly.

Description

Membrane oxygenator integrated with centrifugal pump
Technical Field
The invention relates to the technical field of medical instrument products, in particular to a membrane oxygenator integrated with a centrifugal pump.
Background
The hollow fiber membrane type oxygenator (hereinafter referred to as oxygenator) enables the gold standard of the current blood ocean river to be gradually applied to more medical fields such as respiratory support, first aid, neonate even battlefield first aid and the like from an instrument for supporting heart surgery in the long-term use process;
Since conventional oxygenators are products developed for cardiac surgery, only short-term applications in the operating room are considered. Therefore, the oxygenators on the market at present have many problems in the aspect of expanded use, especially when life support is needed in the moving process in first aid, hospital transport and the like, and have many defects, such as huge equipment volume, large amount of pipeline preparation, slow connection, complexity, inconvenient movement and the like, so that the oxygenators are greatly limited in clinical use.
Along with the increasing clinical demands, how to make the traditional extracorporeal circulation operation simpler and faster, the equipment volume is smaller and more flexible, so that the extracorporeal circulation count can be better applied to first aid, and the transportation becomes one of the targets of the extracorporeal circulation technology. The volume of the existing membrane oxygenator and matching equipment is mostly 0.4 x 1.5 cubic meters; the operation steps are complicated, the number of leakage points is large, and a connecting pipeline of at least 1 meter is needed, so that the risk of damaging blood is increased.
Disclosure of Invention
In order to solve the problems, the invention provides a membrane oxygenator integrated with a centrifugal pump, which comprises a centrifugal pump system and a gas exchange device; the centrifugal pump system is fixedly arranged below the gas exchange device; the membrane oxygenator also comprises a blood inlet nozzle, a bleeding nozzle, an air inlet nozzle and an air exhaust nozzle.
Still further, the centrifugal pump system includes a blood inlet housing, a blood outlet housing, an impeller, and a lower housing; the impeller is arranged inside the blood inlet shell, and the blood inlet shell is arranged inside the blood inlet shell; the lower shell is fixedly arranged below the blood inlet shell and the blood outlet shell.
Further, the gas exchange device comprises a shell, an upper cover, a lower cover, a first blocking layer, a second blocking layer, a blood inlet mandrel, an outer mandrel and an oxygen pressing film; the upper cover and the lower cover are arranged on the top surface and the bottom surface of the shell; a blood channel is arranged in the middle of the upper cover; the blood channel is fixedly connected with the blood inlet mandrel through mortise and tenon joints; the outer mandrel is arranged outside the blood inlet mandrel; the oxygen pressing film is positioned between the shell and the outer mandrel; the first blocking layer is positioned on the top of the cavity between the blood inlet mandrel and the outer mandrel and on the oxygen compression film between the outer mandrel and the shell; the second blocking layer is positioned at the bottom of the cavity between the oxygen pressing film and the shell; one or more bleeding holes are arranged on the outer mandrel.
Further, a bleeding shell of the centrifugal pump system is arranged on a lower cover of the gas exchange device, and the top of the bleeding shell is connected with the outer core shaft in a mortise-tenon mode; the blood inlet shell is fixed on the blood inlet mandrel and fixedly connected through mortise and tenon joints; the centrifugal pump system and the gas exchange device are coaxially connected.
Further, a first blood through channel is formed inside the impeller and the blood inlet shell; one or more bleeding holes are arranged on the blood inlet shell.
Further, a second blood passageway is formed between the blood-feeding housing and the blood-feeding housing.
Further, the blood inlet mandrel is internally provided with a first blood channel; a second blood channel is formed between the blood inlet mandrel and the outer mandrel; a third blood channel is formed between the oxygen compression membrane and the housing.
Further, the first blocking layer is positioned on top of the second blood channel on the gas exchange device and on the oxygen compression membrane; the second blocking layer is positioned at the bottom of the third blood channel.
Further, the blood inlet nozzle is fixed on the blood channel of the upper cover and communicated with the first blood channel; the bleeding nozzle is positioned at the lower part of the shell and communicated with the third blood channel; the air inlet nozzle is positioned on the upper cover; the exhaust nozzle is positioned on the lower cover.
Further, the blood inlet mandrel, the outer mandrel, the shell, the lower cover, the upper cover, the impeller, the blood inlet shell and the blood outlet shell are all coaxially arranged.
The membrane oxygenator of the integrated centrifugal pump provided by the invention has the following technical effects:
(1) The centrifugal pump system is integrated in the gas exchange device, has high integration degree, reduces the volume of the whole system, is convenient to carry, and is more convenient to be applied to first aid, transportation and other mobile life support.
(2) The centrifugal pump and the gas exchange device are integrated into a whole, and the centrifugal pump and the gas exchange device are not connected through an external hose, so that operation steps in emergency treatment are reduced, and rescue time is saved; the use of a hose is reduced, thereby reducing the pre-charge, and thus the risk of blood damage and particle shedding into the human body.
(3) The centrifugal pump system is adopted instead of extrusion, so that the risk of falling particles in the extrusion process is reduced, the particles are prevented from entering the human body, and the safety performance is improved.
(4) The volume of the product (including matched equipment) is 0.4-0.4 cubic meter, the weight is less than 50kg, the product is convenient to carry and transport, and the occupied area of medical supplies is reduced.
(5) Only need take over twice in the operation process, reduce the risk of manual operation error, the leakage point is less simultaneously, the equipment of carrying has also been less simultaneously, the cost of consumption has been less.
Drawings
FIG. 1 is a schematic cross-sectional view of an oxygenator provided by the present invention.
Fig. 2 is a schematic structural view of the oxygenator provided by the present invention.
Fig. 3 is a schematic view showing the blood flow direction of the oxygenator according to the present invention.
Fig. 4 is a schematic view of the direction of air flow of the oxygenator provided by the present invention.
Fig. 5 is a schematic view of a mortise and tenon joint structure of the oxygenator provided by the invention.
Detailed Description
Example 1
As shown in fig. 1,2,3 and 4, the membrane oxygenator of the integrated centrifugal pump provided by the invention comprises a centrifugal pump system and a gas exchange device; the centrifugal pump system is fixedly arranged below the gas exchange device; the membrane oxygenator also comprises a blood inlet nozzle 3, a bleeding nozzle 4, an air inlet nozzle 5 and an air outlet nozzle 6.
Specifically, the centrifugal pump system includes a blood inlet housing 11, a blood outlet housing 12, an impeller 13, and a lower housing 14; the impeller 13 is arranged inside the blood inlet shell 11, and the blood inlet shell 12 is arranged inside the blood inlet shell 11; the lower case 14 is fixedly installed under the blood feeding case 11 and the blood discharging case 12.
Specifically, the gas exchange device comprises a shell 21, an upper cover 22, a lower cover 23, a first blocking layer 24, a second blocking layer 25, a blood inlet mandrel 26, an outer mandrel 27 and an oxygen pressing film 28; the upper cover 22 and the lower cover 23 are installed on the top and bottom surfaces of the housing 21; a blood channel is arranged in the middle of the upper cover 22; the blood channel is fixedly connected with the blood inlet mandrel 26 through mortise and tenon joints, and mainly plays a role in sealing and fixing; the outer mandrel 27 is external to the blood feeding mandrel 26; the oxygen compression film 28 is located between the housing 21 and the outer mandrel 27; the first blocking layer 24 is positioned on top of the cavity between the blood feeding mandrel 26 and the outer mandrel 27, and on the oxygen compression film between the outer mandrel 27 and the housing 21; the second blocking layer 25 is positioned at the bottom of the cavity between the oxygen compressing film 28 and the shell 21; the outer mandrel 27 is provided with one or more bleeding holes.
Specifically, the bleeding casing 12 of the centrifugal pump system is mounted on the lower cover 22 of the gas exchange device, and the top of the bleeding casing is in mortise-tenon connection with the outer core shaft 27; the blood inlet shell 11 is fixed on the blood inlet mandrel 26 and fixedly connected through mortise and tenon joints; the centrifugal pump system and the gas exchange device are coaxially connected.
Specifically, the impeller 13 and the blood inlet housing 11 form a first blood channel 7 inside; the blood inlet shell 11 is provided with one or more bleeding holes.
Specifically, a second blood passage 8 is formed between the blood inlet housing 11 and the blood outlet housing 12.
Specifically, the inside of the blood inlet mandrel 26 is a first blood channel 7; a second blood channel 8 is formed between the blood inlet mandrel 26 and the outer mandrel 27; a third blood channel 9 is formed between the oxygen compression membrane 28 and the housing 21.
In particular, the first blocking layer 24 is located on top of the second blood channel 8 on the gas exchange device and on the oxygen compression membrane 28; the second occlusion layer 25 is located at the bottom of the third blood channel 9.
Specifically, the blood inlet nozzle 3 is located on the blood channel of the upper cover 21 and is communicated with the first blood channel 7; the bleeding nozzle 4 is positioned at the lower part of the shell 21 and is communicated with the third blood channel 9; the air inlet nozzle 5 is positioned on the upper cover 22; the exhaust nozzle 6 is located on the lower cover 23.
Specifically, the blood inlet mandrel 26, the outer mandrel 27, the shell 23, the lower cover 22, the upper cover 21, the impeller 13, the blood inlet shell 11 and the blood outlet shell 12 are all coaxially arranged
Working principle: in use, blood enters the blood passageway through the inlet nozzle 3 on the gas exchange device and then flows along it into the first blood passageway 7 in the inlet spindle 26, down the first blood passageway 7 and into the first blood passageway 7 between the inlet housing 11 and the impeller 13 on the centrifugal pump system. Blood enters the second blood channel 8 between the blood inlet housing 11 and the blood outlet housing 12 from one or more bleeding holes in the blood inlet housing 11 under the centrifugal force of the impeller 13, and enters the second blood channel 8 between the blood inlet spindle 16 and the outer spindle 27 of the gas exchange device along the second blood channel 8 under the centrifugal force of the impeller 13. Since the top of the second blood channel 8 on the gas exchange device is provided with the first blocking layer 24, blood enters the oxygen compression membrane 28 through the outer core shaft 27 under the action of pressure, enters the third blood channel 9 between the oxygen compression membrane 28 and the housing 21 after exchange with gas in the oxygen compression membrane 28 is completed, and finally flows out from the bleeding nozzle 4 on the housing 21. The bottom of the third blood channel 9 is provided with the second occlusion layer 25 preventing blood from flowing into the centrifugal pump system.
The gas enters from the air inlet nozzle 5 on the upper cover 22 of the gas exchange device, then enters the top of the oxygen compression film 28 through the first blocking layer 24, is discharged from the bottom of the oxygen compression film 28 after being subjected to gas exchange with blood in the oxygen compression film 28, and finally is discharged from the air outlet nozzle 6 on the lower cover 23 of the gas exchange device.
The gas and blood flow in from the air inlet nozzle 5 and the blood inlet nozzle 3 respectively, and then the two complete gas exchange in the oxygen compression film 28, and then are discharged from the air outlet nozzle 6 and the blood outlet nozzle 4 respectively.
As shown in fig. 5, the blood feeding mandrel 26 and the blood feeding shell 11 are fixedly connected through mortise and tenon joints; the top of the blood feeding core shaft 26 is a tenon, the top of the blood feeding shell 11 is a mortise, the tenon at the bottom of the blood feeding core shaft 26 is clamped into the mortise at the top of the blood feeding shell 11, and the tenon and the mortise are connected and fixed. Adopt mortise and tenon joint, can be with both fixed connection, can play sealed effect simultaneously, prevent blood seepage. Other mortise and tenon structures in the invention are the same as the mortise and tenon structures.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims (3)

1. A membrane oxygenator integrated with a centrifugal pump, characterized by: comprises a centrifugal pump system and a gas exchange device; the centrifugal pump system is fixedly arranged below the gas exchange device; the membrane oxygenator also comprises a blood inlet nozzle, a bleeding nozzle, an air inlet nozzle and an exhaust nozzle; the centrifugal pump system comprises a blood inlet shell, a blood outlet shell, an impeller and a lower shell; the impeller is arranged inside the blood inlet shell, and the blood inlet shell is arranged inside the blood inlet shell; the lower shell is fixedly arranged below the blood inlet shell and the blood outlet shell;
The gas exchange device comprises a shell, an upper cover, a lower cover, a first blocking layer, a second blocking layer, a blood inlet mandrel, an outer mandrel and an oxygen pressing film; a blood channel is arranged in the middle of the upper cover; the upper cover and the lower cover are arranged on the top surface and the bottom surface of the shell; the blood channel is fixedly connected with the blood inlet mandrel through mortise and tenon joints; the outer mandrel is arranged outside the blood inlet mandrel; the oxygen pressing film is positioned between the shell and the outer mandrel; the first blocking layer is positioned at the bottom of the cavity between the blood inlet mandrel and the outer mandrel and on the oxygen compression film between the outer mandrel and the shell; the second blocking layer is positioned at the bottom of the cavity between the oxygen pressing film and the shell; one or more bleeding holes are formed in the outer mandrel; a first blood through channel is formed inside the impeller and the blood inlet shell; one or more bleeding holes are formed in the blood inlet shell; a second blood channel is formed between the blood inlet shell and the blood outlet shell; the interior of the blood inlet mandrel is a first blood channel; a second blood channel is formed between the blood inlet mandrel and the outer mandrel; a third blood channel is formed between the oxygen pressing film and the shell; the first blocking layer is positioned on the top of the second blood channel and the top of the oxygen compression film on the gas exchange device; the second blocking layer is positioned at the bottom of the third blood channel; the blood inlet nozzle is fixed on the blood channel of the upper cover and communicated with the first blood channel; the bleeding nozzle is positioned at the lower part of the shell and communicated with the third blood channel; the air inlet nozzle is positioned on the upper cover; the exhaust nozzle is positioned on the lower cover.
2. A membrane oxygenator integrated with a centrifugal pump according to claim 1, wherein: the bleeding shell of the centrifugal pump system is fixed on the lower cover of the gas exchange device, and the top of the bleeding shell is connected with the outer core shaft in a mortise-tenon mode; the blood inlet shell is fixed on the blood inlet mandrel and fixedly connected through mortise and tenon joints; the centrifugal pump system and the gas exchange device are coaxially connected.
3. A membrane oxygenator integrated with a centrifugal pump according to claim 2, characterized in that: the blood inlet core shaft, the outer core shaft, the shell, the lower cover, the upper cover, the impeller, the blood inlet shell and the blood outlet shell are all coaxially arranged.
CN201811417334.3A 2018-11-26 2018-11-26 Membrane oxygenator integrated with centrifugal pump Active CN109224164B (en)

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Application Number Priority Date Filing Date Title
CN201811417334.3A CN109224164B (en) 2018-11-26 2018-11-26 Membrane oxygenator integrated with centrifugal pump

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Application Number Priority Date Filing Date Title
CN201811417334.3A CN109224164B (en) 2018-11-26 2018-11-26 Membrane oxygenator integrated with centrifugal pump

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CN109224164A CN109224164A (en) 2019-01-18
CN109224164B true CN109224164B (en) 2024-10-22

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Publication number Priority date Publication date Assignee Title
CN112336982A (en) * 2019-08-09 2021-02-09 北京万东康源科技开发有限公司 Portable artificial heart-lung integrated auxiliary device

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JPH1033667A (en) * 1996-07-24 1998-02-10 Kuraray Co Ltd Hollow fiber type fluid treatment device
US6368557B1 (en) * 1998-12-30 2002-04-09 Cardiovention, Inc. Integrated blood oxygenator and pump system having means for reducing manifold flooding
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EP1796779A1 (en) * 2004-09-13 2007-06-20 University of Maryland, Baltimore Blood pump-oxygenator system
EP1930034B1 (en) * 2006-12-07 2012-11-14 Thoratec LLC An integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system
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CN108030970A (en) * 2018-01-16 2018-05-15 王辉山 A kind of Portable external circulatory system

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CN209286309U (en) * 2018-11-26 2019-08-23 江苏美思康医疗科技有限公司 A kind of membrane oxygenator of integrated centrifugal pump

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