CN108888267A - Acquisition methods of the difference burn degree skin in terahertz wave band characteristic parameter - Google Patents
Acquisition methods of the difference burn degree skin in terahertz wave band characteristic parameter Download PDFInfo
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- CN108888267A CN108888267A CN201810421413.5A CN201810421413A CN108888267A CN 108888267 A CN108888267 A CN 108888267A CN 201810421413 A CN201810421413 A CN 201810421413A CN 108888267 A CN108888267 A CN 108888267A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/0507—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves using microwaves or terahertz waves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
- A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
A kind of acquisition methods of skin characteristic parameter based on Terahertz transmitted spectrum are claimed in the present invention, to realize the accurate judgement to burn grade.Terahertz time-domain spectroscopy experiment is carried out by the young age porcine skin to different burn degree, it is determined that for skin characteristic parameter --- absorption coefficient and the refractive index of grade judgement of burning, and burn is divided into three grades.In addition, obtaining the full frequency band change curve of burn degree and characteristic parameter by the Fast Fourier Transform (FFT) to terahertz time-domain spectrum, wherein promotion of the skin absorption coefficient with burn degree is on a declining curve, and refractive index is in contrast.By the burn ranked queries table given by change curve, the judgement of burn grade can be fast and accurately carried out in the case where known skin absorption coefficient or refractive index, have biggish application value in clinical medicine and medical teaching experiment.
Description
Technical field
The invention belongs to terahertz time-domain spectroscopic technologies, it is intended to one kind be proposed under terahertz wave band, for different burnings
Hurt the absorption coefficient of degree skin and the calculation method of refractive index, achievees the purpose that accurate definition burn grade.
Background technique
In nowadays skin burn judgement field, accurate evaluation skin burn grade is to the corresponding therapeutic scheme of determination to pass
It is important, but the subjective judgement for being to rely on existing detection method and doctor can not accurately determine burn grade.In addition, burning
Hurt initial stage processing and situation monitoring is also very crucial to the rehabilitation for preventing wound infection and patient, existing imaging detection method is all
There are certain deficiencies, and terahertz detection method can provide necessary support for detection burn.
Theoretically, the main purpose of tissue of burn detection is the composition and state of determining oedema, and Terahertz is to oedema group
It knits middle liquid flowing and the variation of ingredient is very sensitive, and this it appears that the absorption peak of water element in frequency domain spectra.
It can be in the hope of different degrees of burned skin for the absorptivity and absorption of Terahertz by the analysis for Terahertz frequency domain spectra
The relationship of coefficient, it is existing so as to quickly pass through the burn grade of Terahertz transmission spectrum accurate definition skin under experimental conditions
There is research to focus primarily on tera-hertz spectra imaging, to reach the accurate detection to pathological tissues such as cancer cells.In addition, Terahertz
Longer the time required to imaging, there are still defects in the timeliness of condition-inference, shorter into spectrum required time, are more suitable for facing
The extensive use of bed medically.
Summary of the invention
Present invention seek to address that the above problem of the prior art.Propose accurately determining for a kind of pair of skin burn grade
Acquisition methods of the difference burn degree skin in terahertz wave band characteristic parameter.Technical scheme is as follows：
A kind of acquisition methods of different burn degree skin in terahertz wave band characteristic parameter comprising following steps：
The slice of the burned skin of measurand is obtained, the section of the slice is same skin layer；
Each group of slice thickness is measured, the average thickness of slice is obtained；
Foam carrier is made, in the central ablation rectangle cavity of foam carrier maximum cross-section, and gained slice is put into square
In shape cavity；
It is radiated at thz laser on dermatological specimens, and terahertz time-domain spectrum is measured to determine burn area,
The transmission information under its different frequency is measured, repetition obtains the data of several groups slice；
Fast Fourier Transform (FFT) is carried out to data measured by each group, its amplitude and phase data is obtained, seeks skin
The refractive index and absorption coefficient of skin sample；The quantitative relationship that refractive index and absorption coefficient change with burn degree is obtained, is provided not
With the change curve under burn degree full frequency band.
Further, the slice of the burned skin of the measurand is using slices across.
Further, described that each group of slice thickness is measured, the average thickness of slice is obtained, is specifically included：
Each group of slice thickness is measured with measuring tool, is surveyed in slice diagonal line, geometrically symmetric position of center line
Amount several times, takes mean value as the average thickness of slice.
Further, skin, which is burnt, when the slice is put into rectangle cavity faces outwardly.
Further, described to be radiated at thz laser on dermatological specimens, and to terahertz time-domain spectrum measure with
It determines burn area, specifically includes：Skin and foam carrier are placed on the objective table of terahertz imaging experiment porch, foam
Carrier places the side of slice towards THz laser source, and ensures that laser source can be irradiated in sample.
Further, upon irradiation, the objective table on Terahertz platform further includes the steps that micro-shifting to measure different frequency
Under transmission information.
Further, the terahertz emission electric field that record terahertz time-domain spectroscopy system obtains when/frequency domain amplitude and frequency
The data of domain phase
Further, described that Fast Fourier Transform (FFT) is carried out to data measured by each group, obtain its amplitude and phase
Position data, seek the refractive index and absorption coefficient of dermatological specimens；
Wherein, the calculation formula of sample refractive index isThe calculation formula of absorption coefficient is
It advantages of the present invention and has the beneficial effect that：
The innovation of the invention consists in that being carried out into spectrum and non-imaged behaviour using terahertz time-domain spectroscopy system to burned skin
Make, and the characteristic parameter of skin is selected again, absorption coefficient and refractive index are defined as to be used to burn what grade determined
Burn is newly defined as 3 either shallow, moderate, severe grades on this basis by characteristic parameter.In addition, by Time Domain Spectrum into
Row FFT transform, the present invention obtain full frequency band skin characteristic amount with the changing rule of burn degree, and wherein absorption coefficient is with burn
The increase of degree is substantially on a declining curve, and refractive index is substantially in rising trend with the increase of burn degree.The present invention is also by changing
Curve extracts the burn ranked queries table under specific frequency, can correspond to skin absorption coefficient or refractive index in the known frequency
In the case of, fast and accurately carry out the judgement of burn grade.
It is an advantage of the current invention that after user obtains absorption coefficient or the refractive index characteristics amount of burned skin, it can be right
According to burn degree inquiry table, the judgement of skin burn grade is rapidly and accurately carried out, avoids the subjectivity that burn grade determines.
Detailed description of the invention
Fig. 1 is that the present invention provides the process for using figure of preferred embodiment；
Fig. 2 is the burned skin slice position schematic diagram in the present invention；
Fig. 3 is tera-hertz spectra test device index path used in the present invention；
Fig. 4 is the absorption coefficient change curve under the different burn degree skin full frequency bands that the present invention obtains；
Fig. 5 is the variations in refractive index curve under the different burn degree skin full frequency bands that the present invention obtains；
Fig. 6 is the burn ranked queries table provided through the invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, detailed
Carefully describe.Described embodiment is only a part of the embodiments of the present invention.
The present invention solve above-mentioned technical problem technical solution be：
1. using complex refractivity indexIt indicates the refractive index of absorbing medium, and defines absorption coefficient (ω), characterize sample
To the degree of absorption of Terahertz, α (ω) is bigger, and it is more to show that sample absorbs THz wave.Then have：
α (ω)=2 ω k (ω)/c (2)
Wherein n (ω) is usual measured refractive index, and k (ω) is related with the absorption of medium, referred to as extinction coefficient.
2. since absorption coefficient of the foam to Terahertz is similar with air, and only the delay in generation time, work as placement
When foam, as reference signal Eref(ω)；When placing sample, then the signal carries sample information, is denoted as sample signal
Esam(ω).Assuming that thickness of sample is uniform, and keeps surface parallel, and as THz wave propagation distance L in the medium, phase
Corresponding change can occur with amplitude.
Wherein, δ (ω) characterizes phase difference, and p (ω, L) characterizes transmission factor of the THz wave in transmission process.
Note air is medium 1, and foam is medium 2, and sample is medium 3, uses n1,n2,n3Respectively indicate air, foam and
The refractive index of sample.Then have：
Eref(ω)=Ein(ω)t12t21p2(ω,L) (5)
Esam(ω)=Ein(ω)t12t23t31p2(ω,x)p3(ω,d) (6)
H (ω)=ρ (ω) e-jφ(ω) (7)
Wherein, Eim(ω) indicates incident THz wave intensity, tijIndicate that THz wave is propagated from medium i to medium j
Required time, H (ω) are multiple transmission function, and ρ (ω), φ (ω) characterize its modulus value and phase angle respectively.ki(ω)=2 π ni/ λ is indicated
Extinction coefficient of the medium to THz wave, x=L-d, L are experiment sample (including foam) integral thickness, and d is the skin that is detected
The thickness of sample.
3. the k in the case where THz wave absorbs weaker3(ω)/n3(ω) < < 1, then can be by ρ (ω), and φ (ω) is into one
Step is expressed as：
By formula (8), (9) can be derived, THz wave passes through the refractive index function of sample, extinction function and absorption coefficient letter
Number is：
The invention proposes a kind of acquisition methods of skin characteristic parameter based on Terahertz transmitted spectrum, to realize to skin
The accurate judgement of skin burn grade, concrete implementation mode are：
(1) under the laboratory condition of 20.3 DEG C of room temperature and humidity 33.2%, with constant temperature electric iron (250 DEG C~300 DEG C)
Burn processing is carried out to the skin sample of fresh young age pig.When burn, only epidermis contacts control skin with electric iron.
(2) the fresh young age porcine skin sample of health and different burn degree is taken to carry out slices across, order gained section is
Same skin layer.Sample sections thickness is about 0.55mm, and area is about 1.5cm*1.5cm, and guarantees that the burn area of skin exists
Gained is sliced in range, slice position signal such as Fig. 2.
(3) each group of slice thickness is measured with electronic vernier caliper.In slice diagonal line, geometrically symmetric center line
Position measures 4 times, takes mean value as the average thickness of slice.
(4) foam carrier that production size is 3cm*3cm*0.8cm, the central ablation size in foam carrier maximum cross-section
About 1.5cm*1.5cm, the rectangle cavity that depth is 2mm, and gained slice in (2) is put into cavity immediately, enable skin be burnt
Wound faces outwardly.
(5) skin and foam carrier are placed on the objective table of terahertz imaging experiment porch (experiment porch index path
As shown in Figure 3), foam carrier places the side being sliced towards THz laser source, and ensures that laser source can be irradiated in sample.
(6) objective table is operated by data acquisition software, is radiated at thz laser on dermatological specimens, and to Terahertz
Time Domain Spectrum measures the transmission information measured under its different frequency to determine burn area.
(7) the objective table micro-shifting on Terahertz platform is made by data acquisition software, repeats operation 3-5 times of step (6),
Achieve the purpose that reduce error in data processing.
(8) (4)-(7) are repeated and measures each group of slice of data.
(9) Fast Fourier Transform (FFT) is carried out to data measured by each group, obtains its amplitude and phase data.Pass through
Processing method given herein seeks the refractive index and absorption coefficient of dermatological specimens.
(10) quantitative relationship that refractive index and absorption coefficient change with burn degree is obtained using MATLAB, provides different burnings
Hurt change curve such as Fig. 4, Fig. 5 under degree full frequency band, and the burn grade under different characteristic amount is summed up according to expression formula and is looked into
Ask table such as Fig. 6.
The above embodiment is interpreted as being merely to illustrate the present invention rather than limit the scope of the invention.?
After the content for having read record of the invention, technical staff can be made various changes or modifications the present invention, these equivalent changes
Change and modification equally falls into the scope of the claims in the present invention.
Claims (8)
1. a kind of different burn degree skins are in the acquisition methods of terahertz wave band characteristic parameter, which is characterized in that including following
Step：
The slice of the burned skin of measurand is obtained, the section of the slice is same skin layer；
Each group of slice thickness is measured, the average thickness of slice is obtained；
Foam carrier is made, in the central ablation rectangle cavity of foam carrier maximum cross-section, and gained slice is put into rectangle sky
In hole；
It is radiated at thz laser on dermatological specimens, and terahertz time-domain spectrum is measured to determine burn area, measure
Transmission information under its different frequency, repetition obtain the data of several groups slice；
Fast Fourier Transform (FFT) is carried out to data measured by each group, its amplitude and phase data is obtained, seeks skin-like
This refractive index and absorption coefficient；The quantitative relationship that refractive index and absorption coefficient change with burn degree is obtained, different burnings are provided
Hurt the change curve under degree full frequency band.
2. acquisition methods of the different burn degree skins according to claim 1 in terahertz wave band characteristic parameter, spy
Sign is that the slice of the burned skin of the measurand is using slices across.
3. acquisition methods of the different burn degree skins according to claim 1 in terahertz wave band characteristic parameter, spy
Sign is, described to measure to each group of slice thickness, obtains the average thickness of slice, specifically includes：
Each group of slice thickness is measured with measuring tool, if in slice diagonal line, the measurement of geometrically symmetric position of center line
Dry time, take mean value as the average thickness of slice.
4. acquisition methods of the different burn degree skins according to claim 1 in terahertz wave band characteristic parameter, spy
Sign is that skin, which is burnt, when the slice is put into rectangle cavity faces outwardly.
5. acquisition methods of the different burn degree skins according to claim 1 in terahertz wave band characteristic parameter, spy
Sign is, described to be radiated at thz laser on dermatological specimens, and measures terahertz time-domain spectrum to determine the area that burns
Domain specifically includes：Skin and foam carrier are placed on the objective table of terahertz imaging experiment porch, foam carrier placement is cut
The side of piece ensures that laser source can be irradiated in sample towards THz laser source.
6. acquisition methods of the different burn degree skins according to claim 5 in terahertz wave band characteristic parameter, spy
Sign is that upon irradiation, the objective table on Terahertz platform further includes the steps that micro-shifting to measure the letter of the transmission under different frequency
Breath.
7. acquisition methods of the different burn degree skins according to claim 5 in terahertz wave band characteristic parameter, spy
Sign is, terahertz emission electric field when/frequency domain amplitude and frequency domain phase and its variation.
8. acquisition methods of the different burn degree skins according to claim 5 in terahertz wave band characteristic parameter, spy
Sign is, described to carry out Fast Fourier Transform (FFT) to data measured by each group, obtains its amplitude and phase data, seeks
The refractive index and absorption coefficient of dermatological specimens；
Wherein, the calculation formula of sample refractive index isThe calculation formula of absorption coefficient is
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917500A (en) * | 2019-12-02 | 2020-03-27 | 雄安华讯方舟科技有限公司 | Diagnosis and treatment system for burned tissues |
| CN114931115A (en) * | 2022-05-27 | 2022-08-23 | 浙江大学 | Poultry hatching egg gender rapid identification method based on flexible metamaterial |
| CN115177233A (en) * | 2022-06-16 | 2022-10-14 | 西安电子科技大学 | Method for detecting biological tissue by using photoacoustic effect of terahertz waves and application thereof |
| CN117942062A (en) * | 2024-03-27 | 2024-04-30 | 天津大学四川创新研究院 | Skin barrier damage detection system and method based on terahertz wave band |
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2018
- 2018-05-04 CN CN201810421413.5A patent/CN108888267A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917500A (en) * | 2019-12-02 | 2020-03-27 | 雄安华讯方舟科技有限公司 | Diagnosis and treatment system for burned tissues |
| CN114931115A (en) * | 2022-05-27 | 2022-08-23 | 浙江大学 | Poultry hatching egg gender rapid identification method based on flexible metamaterial |
| CN115177233A (en) * | 2022-06-16 | 2022-10-14 | 西安电子科技大学 | Method for detecting biological tissue by using photoacoustic effect of terahertz waves and application thereof |
| CN117942062A (en) * | 2024-03-27 | 2024-04-30 | 天津大学四川创新研究院 | Skin barrier damage detection system and method based on terahertz wave band |
| CN117942062B (en) * | 2024-03-27 | 2024-06-11 | 天津大学四川创新研究院 | Skin barrier damage detection system and method based on terahertz wave band |
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Application publication date: 20181127 |