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CN108853433A - A kind of Chinese medicine and preparation method thereof for treating diabetic nephropathy - Google Patents

A kind of Chinese medicine and preparation method thereof for treating diabetic nephropathy Download PDF

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Publication number
CN108853433A
CN108853433A CN201811009506.3A CN201811009506A CN108853433A CN 108853433 A CN108853433 A CN 108853433A CN 201811009506 A CN201811009506 A CN 201811009506A CN 108853433 A CN108853433 A CN 108853433A
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China
Prior art keywords
parts
radix
chinese medicine
diabetic nephropathy
treatment
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CN201811009506.3A
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Chinese (zh)
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阴永辉
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Individual
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Individual
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    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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Abstract

The present invention relates to technical field of traditional Chinese medicines, particularly disclose a kind of Chinese medicine and preparation method thereof for treating diabetic nephropathy.The Chinese medicine of the treatment diabetic nephropathy, using Radix Astragali, Radix Angelicae Sinensis, Chinese yam, Radix Salviae Miltiorrhizae, Radix Codonopsis, radix paeoniae rubra, motherwort, the fruit of Cherokee rose, radix rehmanniae recen, Fructus Corni, the fruit of glossy privet, safflower, Rhizoma Chuanxiong, Semen Cuscutae, radix achyranthis bidentatae, leech, pheretima, Radix Notoginseng, rheum officinale, Poria cocos, rhizoma alismatis, fleabane flower, gynostemma pentaphylla, tripterygium wilfordii, corn stigma, Herba Euphorbiae Humifusae, turmeric and root of kirilow rhodiola as raw material, it is mixed according to certain parts by weight.The present invention is made of pure Chinese medicine, the compound CP method relevant regulations of each component, using the compatibility effect of each taste Chinese medicine, is free of chemical components, hormone-free, has no toxic side effect, and treating both manifestation and root cause of disease has the function that preferably hypoglycemic and prevention and treatment diabetic nephropathy.

Description

A kind of Chinese medicine and preparation method thereof for treating diabetic nephropathy
（One）Technical field
The present invention relates to technical field of traditional Chinese medicines, in particular to a kind of Chinese medicine and preparation method thereof for treating diabetes mind soldier.
（Two）Background technique
The disease incidence of diabetes just increases year by year, and nearly 10 years diabetes popularities are even more serious.Diabetes B（T2DM）Account for sugar The 90% of the total case of urine disease, it has also become seriously affect one of the disease of mankind nowadays health.Nowadays diabetes mellitus in China patient occupies First place in the world.China has 1,300,000 people to die of diabetes and its complication within 2015, wherein 40.8% man-year age is lower than 60 years old, by Rejuvenation trend is gradually presented.T2DM vascular complication be mainly disable, the cause of death.Wherein, diabetic nephropathy（Diabetic Nephropathy, DN）It is one of the major chronic microvascular complication of diabetes, and leads to End-stage renal failure Major reason.
The significant damage brought by the diabetes and its complication, doctors attempt various treatment methods to treat and subtract Slow conditions of patients and pain.Motherland's medicine thinks the disease categories such as diabetic nephropathy ownership " quenching one's thirst ", " oedema ", basic pathogenesis For " asthenia in origin and asthenia in superficiality ".This void refers to the deficient of the five internal organs negative and positive of qi and blood, and real mark is that blood stasis hinders network.《The big opinion of Plain Questions YIN YANG classification of natural phenomena》Speech： " treatment of disease must aim at its pathogenesis ", the embodiment for being organic conception and diagnosis and treatment in treatment is seen of searching for the primary cause of disease in treatment, is the master of traditional Chinese medicine treatment Lead thought.The diabetic nephropathy interpretation of the cause, onset and process of an illness is qi deficiency to blood stasis, therefore treatment should take into account " deficiency of vital energy " and " blood stasis "." QI invigorating ", the first prosperous energy of gas Green blood, second gas row then blood, for the method effected a permanent cure；" promoting blood circulation " then the stasis of blood must be logical except blood vessels, and new blood must be raw, for the method for temporary solution.Therefore its Treating big method is qi and activate blood circulation.
（Three）Summary of the invention
In order to compensate for the shortcomings of the prior art, the present invention provides a kind of simple processes, low in cost, effective treatment sugar Urinate the Chinese medicine and preparation method thereof of sick nephrosis.
The present invention is achieved through the following technical solutions：
A kind of Chinese medicine for treating diabetic nephropathy, it is characterized in that, it is mixed by the raw material of following parts by weight：Radix Astragali 20-40 Part, 15-25 parts of Radix Angelicae Sinensis, 10-20 parts of Chinese yam, 20-40 parts of Radix Salviae Miltiorrhizae, 10-20 parts of Radix Codonopsis, 10-20 parts of radix paeoniae rubra, 10-20 parts of motherwort, 20-40 parts of the fruit of Cherokee rose, 10-20 parts of radix rehmanniae recen, 8-12 parts of Fructus Corni, 10-20 parts of the fruit of glossy privet, 9-15 parts of safflower, Rhizoma Chuanxiong 10-20 Part, 10-20 parts of Semen Cuscutae, 10-20 parts of radix achyranthis bidentatae, 9-15 parts of leech, 9-15 parts of pheretima, 2-4 parts of Radix Notoginseng, 6-12 parts of rheum officinale, Poria cocos 10-20 parts, 20-40 parts of rhizoma alismatis, 20-40 parts of fleabane flower, 20-40 parts of gynostemma pentaphylla, 10-20 parts of tripterygium wilfordii, 20-40 parts of corn stigma, 10-20 parts of Herba Euphorbiae Humifusae, 10-20 parts of turmeric, 20-40 parts of root of kirilow rhodiola.
Its preferred weight proportion is：
30 parts of Radix Astragali, 20 parts of Radix Angelicae Sinensis, 15 parts of Chinese yam, 30 parts of Radix Salviae Miltiorrhizae, 15 parts of Radix Codonopsis, 15 parts of radix paeoniae rubra, 15 parts of motherwort, the fruit of Cherokee rose 30 Part, 15 parts of radix rehmanniae recen, 10 parts of Fructus Corni, 15 parts of the fruit of glossy privet, 12 parts of safflower, 15 parts of Rhizoma Chuanxiong, 15 parts of Semen Cuscutae, 15 parts of radix achyranthis bidentatae, water 12 parts of leech, 12 parts of pheretima, 3 parts of Radix Notoginseng, 9 parts of rheum officinale, 15 parts of Poria cocos, 30 parts of rhizoma alismatis, 30 parts of fleabane flower, 30 parts of gynostemma pentaphylla, Thunder God 15 parts of rattan, 30 parts of corn stigma, 15 parts of Herba Euphorbiae Humifusae, 15 parts of turmeric, 30 parts of root of kirilow rhodiola.
Chinese medicine of the present invention is capsule.The mode of taking be it is oral, three times per day, half an hour takes before meals, every time 0.5g, a month as a treatment course.
The present invention combines dialectical argumentation by the research to traditional Chinese medicine, and the multi-party length for collecting many families seeks most preferably to control Treatment scheme is matched through system research, scientific compatibility using Radix Astragali, Radix Angelicae Sinensis by theory of traditional Chinese medical science prescription using natural Chinese traditional medicines raw material 5 other drugs treat diabetic nephropathy caused by qi deficiency to blood stasis patients with type Ⅰ DM, significant effect；In conjunction with Traditional Chinese Medicine technology It is configured to Chinese medicine of the invention meticulously, there is preferable effect to diabetic nephropathy.
The present invention treats the preparation method of the Chinese medicine of diabetic nephropathy, includes the following steps：
（1）Each bulk pharmaceutical chemicals are weighed respectively, it is spare；
（2）Take Chinese yam, Radix Salviae Miltiorrhizae, Radix Codonopsis, radix paeoniae rubra, the fruit of Cherokee rose, safflower, Semen Cuscutae, leech, Poria cocos, fleabane flower, Herba Euphorbiae Humifusae mixing equal It is even, it adds water to cook twice, is collected by filtration after filtrate and merges filtrate twice, be condensed into medicinal extract after cooling, then dries pulverizing is at powder, Obtain compound A；
（3）Take Radix Astragali, Radix Angelicae Sinensis, motherwort, radix rehmanniae recen, Fructus Corni, the fruit of glossy privet, Rhizoma Chuanxiong, radix achyranthis bidentatae, pheretima, Radix Notoginseng, rheum officinale, rhizoma alismatis, Gynostemma pentaphylla, tripterygium wilfordii, corn stigma, turmeric, root of kirilow rhodiola add ethyl alcohol to impregnate, and extract twice, combined extract filters, is condensed into leaching Cream, crushed after being dried obtain compound B；
（4）Compound A and compound B are uniformly mixed, capsule product is made in sterilization.
More excellent technical solution of the invention is：
Step（2）In, twice in decoction, for the first time plus the water of three times weight is boiled by intense fire, is then cooked by slow fire 1 hour, is filtered Collect filtrate and filter residue；Into filter residue plus water regards no filter slag as criterion, and boils by intense fire, is then cooked by slow fire 30 minutes, and filtering is received Collect filtrate.
Step（2）With（3）In, the density of medicinal extract is that 1.1-1.2g/mL is ground into powder, obtains compound after drying at 80 DEG C Object A.
Step（3）In, adding mass concentration is alcohol solution dipping 0.5-1.5 hours of 70%, is extracted twice, each 1-2 is small When, combined extract；The relative density of medicinal extract is 1.2 after concentration.
In drug of the invention, the sweet temperature rise hair of Radix Astragali, function arrogates to oneself tonifying Qi, is " length of tonic "；Energy help three is burnt, internal organs in table All gas；Radix Angelicae Sinensis acrid flavour, hardship, sweet, tepor, have effects that inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving；There are the discussion of Radix Angelicae Sinensis in successive dynasties' successive dynasties Very much, such as《Haigoushen》In mention the power that Radix Angelicae Sinensis has " broken place blood "；Radix Codonopsis, Chinese yam, Fructus Corni etc. have tonifying middle-Jiao and Qi, stop Yearningly, the effect of strengthening the spleen and replenishing qi, nourishes blood and promotes the production of body fluid, the function of Radix Astragali tonifying Qi is helped；Radix Salviae Miltiorrhizae, radix paeoniae rubra, safflower, leech, pheretima, Radix Notoginseng, humid euphorbia It is the blood-breakings such as grass, very strong by the stasis of blood, the power of promoting menstruation, Radix Angelicae Sinensis promoting blood circulation, Po Disorder dissipating bind is helped, turmeric, fleabane flower, gynostemma pentaphylla dissipate the stasis of blood and stop Bitterly, promoting blood circulation and removing obstruction in channels；Root of kirilow rhodiola qi and activate blood circulation is removed obstruction in channels to relieve pain；Corn stigma inducing diuresis for removing edema, rheum officinale, rhizoma alismatis let out turbid；Poria cocos invigorating the spleen；Ox The yin that knee, tripterygium wilfordii, motherwort, the fruit of glossy privet, Semen Cuscutae are tonified the liver and kidney.The benefits of inrigorating qi and promoting blood circulation is played altogether by full side, and it is strong to take into account benefiting yin It is the splenic diarrhea turbid and other effects.
Every medicinal material in prescription is carried out compatibility using conventional method by Chinese medicine of the invention in proportion, by existing preparation work Various clinical applicable dosage forms are made in skill, and every medicinal material used is commercially available by examining qualified Chinese medicine.
Raw medicinal material army of the present invention uses natural Chinese medicine material, prepares simply, and medicine source is extensive, low in cost, abides by The prescriptions principle of Chinese medicine is followed, all medicines share brings out the best in each other, and preparation dose is small, and effective ingredient is easy to discharge, and inhales It receives fastly, bioavilability is high, so that drug effect is sufficiently volatilized, verifies by clinic application, significant in efficacy reliable, medicinal peace, Do not occur toxic side effect, has a extensive future.
Avoided pungent and cold food for duration of medication, avoids emotional stimulation, quits smoking and gives up alcohol, and life wants regular, appropriate to forge Refining.
The present invention is made of pure Chinese medicine, the compound CP method relevant regulations of each component, using the compatibility effect of each taste Chinese medicine, no It is hormone-free containing chemical components, it has no toxic side effect, treating both manifestation and root cause of disease reaches preferably hypoglycemic and prevention and treatment diabetogenous nephrosis The effect of disease, total effective rate is high, and simple process reduces production cost, alleviates the financial burden of patient.
（Four）Specific embodiment
Carry out the explained in details present invention below by specific embodiment, but is not intended as the limitation to the content of present invention.
Embodiment 1：
A kind of Chinese herbal compounds for treating diabetic nephropathy, are prepared by following raw materials
Radix Astragali 30g, Radix Angelicae Sinensis 20g, Chinese yam 15g, Radix Salviae Miltiorrhizae 30g, Radix Codonopsis 15g, radix paeoniae rubra 15g, motherwort 15g, fruit of Cherokee rose 30g, Radix Rehmanniae 15g, Fructus Corni 10g, fruit of glossy privet 15g, safflower 12g, Rhizoma Chuanxiong 15g, Semen Cuscutae 15g, radix achyranthis bidentatae 15g, leech 12g, pheretima 12g, three Seven powder 3g, rheum officinale 9g, Poria cocos 15g, rhizoma alismatis 30g, fleabane flower 30g, gynostemma pentaphylla 30g, tripterygium wilfordii 15g, corn stigma 30g, Herba Euphorbiae Humifusae 15g, turmeric 15g, root of kirilow rhodiola 30g.
The preparation method of the Chinese herbal compounds of above-mentioned treatment diabetic nephropathy is：Take the bulk pharmaceutical chemicals (proportion of above-mentioned parts by weight Unit：Gram) capsule is prepared, concrete operations are：
（1）Each bulk pharmaceutical chemicals are weighed, it is spare；
（2）Take Radix Codonopsis, Chinese yam, Radix Salviae Miltiorrhizae, radix paeoniae rubra, the fruit of Cherokee rose, safflower, Semen Cuscutae, leech, Poria cocos, fleabane flower, Herba Euphorbiae Humifusae mixing equal It is even, add the water of 3 times of weight to boil by intense fire, is then cooked by slow fire 1 hour, filtrate and filter residue is collected by filtration；Water is added into filter residue, It regards no filter slag as criterion, boils by intense fire, be then cooked by slow fire 30 minutes, filtrate is collected by filtration；Merge above-mentioned filtrate twice, it is cooling Afterwards, it is condensed into the medicinal extract that density is 1.1-1.2g/ml；After 80 DEG C of drying, it is ground into powder, as compound A；
（3）Take Radix Astragali, Radix Angelicae Sinensis, motherwort, radix rehmanniae recen, Fructus Corni, the fruit of glossy privet, Rhizoma Chuanxiong, radix achyranthis bidentatae, pheretima, Radix Notoginseng powder, rheum officinale, pool Rush down, gynostemma pentaphylla, tripterygium wilfordii, corn stigma, turmeric, root of kirilow rhodiola add 70% ethyl alcohol to impregnate 0.5-1.5 hour, extraction twice, each 1- 2 hours, combined extract, filtration was condensed into the medicinal extract that relative density is 1.2, and crushed after being dried obtains compound B；
（4）Compound A and compound B are mixed evenly, capsule product is made in sterilization.
Take mode：Oral, three times per day, half an hour takes before meals, each 0.5g, a month as a treatment course.
Embodiment 2：
A kind of Chinese herbal compounds for treating diabetic nephropathy, are prepared by following raw materials,
Radix Astragali 50g, Radix Angelicae Sinensis 35g, Chinese yam 25g, Radix Salviae Miltiorrhizae 50g, Radix Codonopsis 25g, radix paeoniae rubra 25g, motherwort 25g, fruit of Cherokee rose 50g, Radix Rehmanniae 25g, Fructus Corni 15g, fruit of glossy privet 25g, safflower 20g, Rhizoma Chuanxiong 25g, Semen Cuscutae 25g, radix achyranthis bidentatae 25g, leech 20g, pheretima 20g, three Seven powder 5g, rheum officinale 15g, Poria cocos 25g, rhizoma alismatis 50g, fleabane flower 50g, gynostemma pentaphylla 50g, tripterygium wilfordii 25g, corn stigma 50g, Herba Euphorbiae Humifusae 25g, turmeric 25g, root of kirilow rhodiola 50g.
Preparation and instructions of taking such as embodiment 1.
Embodiment 3：
A kind of Chinese herbal compounds for treating diabetic nephropathy, are prepared by following raw materials,
Radix Astragali 40g, Radix Angelicae Sinensis 25g, Chinese yam 20, Radix Salviae Miltiorrhizae 40g, Radix Codonopsis 20g, radix paeoniae rubra 20g, motherwort 20g, fruit of Cherokee rose 40g, Radix Rehmanniae 20g, Fructus Corni 12g, fruit of glossy privet 20g, safflower 16g, Rhizoma Chuanxiong 20, Semen Cuscutae 20g, radix achyranthis bidentatae 20g, leech 16g, pheretima 16g, Radix Notoginseng Powder 4g, rheum officinale 12g, Poria cocos 20g, rhizoma alismatis 40g, fleabane flower 40g, gynostemma pentaphylla 40g, tripterygium wilfordii 20g, corn stigma 40g, Herba Euphorbiae Humifusae 20g, turmeric 20g, root of kirilow rhodiola 40g.
Preparation and instructions of taking such as embodiment 1.
Embodiment 4：Experiment of Zoology
Experiment process：
SPF grades of 8 week old Wistar Adult male rats 90 are selected at random, are provided by Shandong Traditional Chinese Medicine University's Animal Lab., body Weigh 200 ± 20g, ad lib and drinking-water, the control of animal house temperature is at 22-26 DEG C of temperature, humidity 55%, illumination 12/24h.It adapts to Property raising 1 week, blood glucose is to measure weight in normal range (NR), detection fasting blood-glucose（FBG）, triglycerides（TG）, total cholesterol （TC）, low-density lipoprotein（LDL）, high-density lipoprotein（HDL）, Urine proteins creatinine ratio, for 24 hours quantify Urine proteins.
It is randomly divided into blank group（n=10）And modeling group（n=80）.The excision of modeling group rat advance Rats With Unilateral kidney, Method：10% chloraldurate 3.5mL/kg intraperitoneal injection of anesthesia, routine disinfection, midline incision 1-1.5mm, the left kidney of exposure remove rouge Fat and adrenal gland ligature blood vessel, cut off left kidney, sew up the incision, and postoperative rat injects 400,000 units of Penicillin and prevents from infecting, continuously Three days.Give streptozotocin within postoperative 1 week（The sodium citrate buffer solution of pH=4.4 0.1mol/L is dissolved in 0 DEG C, need to be ready-to-use, Final concentration of 10mg/mL is injected by 40mg/kg disposable celiac）.Modeling group gives high glucose and high fat feed 8 weeks, and blank group excision is left Kidney simultaneously injects isodose buffer, gives standard rat chow 8 weeks.72 hours tail vein bloods before use after 8 weeks, continuously three times Random blood sugar >=16.7mmol/L and Urine proteins creatinine ratio >=25mg/mmol, Urine proteins >=150mg person is quantified for 24 hours be determined as Diabetic nephropathy model rat.
The successful rat of modeling 60 is taken, is randomly divided into 3 groups, every group 20, i.e. model group：Any drug, sheet are not applied Invention group example 1 drug 10mg/Kg, control drug group：Apply melbine (10mg/kg), method of application be it is oral, often It sooner or later before meals half when take.It is detected after continuously taking 10 weeks；Blood glucose is monitored again after being discontinued 10 days.
Through detecting：Control drug group and medicine group fasting blood-glucose of the present invention, Urine proteins creatinine ratio, quantitative Urine proteins have It is decreased obviously, drug of the present invention is significantly better than control drug group, and significant in efficacy, after stopping ten days, medicine group of the present invention does not have substantially Rebound is occurred, referring specifically to following table.
Embodiment 5：Clinical case
General information：Outpatient service, III phase of diabetes B nephrosis belong to Qi deficiency blood stasis type patient totally 56, wherein male 30, female 26 Example, patient age 50-80 years old, fasting blood-glucose (FPG) and 2h-plasma glucose (2hPG) were sharply increased, and Urine proteins creatinine Ratio is greater than 25mg/mmol, quantitative Urine proteins are greater than 150mg/24h.Take two courses for the treatment of of drug of the preparation of the embodiment of the present invention 1 Afterwards, above-mentioned biochemical indicator is detected.
It cures：FPG < 6.1mmol/L, 2h blood glucose (2hPG) < 8.0mmol/L, Urine proteins creatinine ratio is in 10~25mg/ Mmol, Urine proteins < 150mg is quantified for 24 hours；
Effectively：Fasting blood-glucose (FPG), 2h-plasma glucose (2hPG) make moderate progress, but not up to normal level, quantitative Urine proteins, Urine proteins creatinine ratio reduces, but not up to normal level；
In vain：Fasting blood-glucose (FPG), postprandial 2h blood glucose (2hPG), quantitative Urine proteins, Urine proteins creatinine ratio nothing obviously change Become.
Therapeutic effect：Healing 10, effective 45, invalid 1, total effective rate 98%.
Embodiment 6：Typical case
57 years old, diabetes B 3 years, there is pale white complexion in Mr. Lin, female, out of strength, and the few lazy speech of gas, dry is drunk more, insomnia and dreamful sleep, gas It is short, it is dynamic then aggravate, vexed, blurred vision, edema of lower extremity.Tongue is dark red, and tongue fur is few, there is indentation, deep thready pulse.Fasting blood-glucose 8.8mmol/ L, 2h-plasma glucose 14.6mmol/L, quantitative Urine proteins 420mg/24h, Urine proteins creatinine ratio are 65mg/mmol, are diagnosed as sugar Urinate sick III phase of nephrosis.The Chinese herbal compounds for giving embodiment 1, after taking 2 course for the treatment of, symptom mitigates, and continues to take 1 course for the treatment of Gong Gu fasting blood-glucose is less than 7.0mmol/L, Urine proteins, Urine proteins creatinine ratio are normal.It is visited after half a year, blood glucose value is normal, kidney function Normally.
Liu, male, 72 years old, 2 medical history 7 years type glycosuria phases, now has developed into III phase of diabetic nephropathy, existing dim complexion, weary Power, dry are drunk more, and shortness of breath, hidrosis receive difference, blurred vision, double lower limb numbness oedema, and tongue is dark red.Indentations at the margin of the tongue, tongue fur is thin white, Slow and sunken pulse.Fasting blood-glucose 12.8mmol/L, 2h-plasma glucose 18.0mmol/L, quantitative Urine proteins 380mg/24h, Urine proteins creatinine Ratio is 52mg/mmol.Now take orally Glimepiride 1, QD, 1 TID of melbine.It gives and implements on the basis of original drug The Chinese herbal compounds of example 1, after taking 2 course for the treatment of, symptom mitigates, and continues to take 1 course for the treatment of consolidation, fasting blood-glucose is less than 7mmol/ L, quantitative Urine proteins, Urine proteins creatinine are than normal.Multiple follow-up later, glucostasis in 7.0mmol/L hereinafter, renal function just Often.

Claims (8)

1. a kind of Chinese medicine for treating diabetic nephropathy, it is characterized in that, it is mixed by the raw material of following parts by weight：Radix Astragali 20- 40 parts, 15-25 parts of Radix Angelicae Sinensis, 10-20 parts of Chinese yam, 20-40 parts of Radix Salviae Miltiorrhizae, 10-20 parts of Radix Codonopsis, 10-20 parts of radix paeoniae rubra, motherwort 10-20 Part, 20-40 parts of the fruit of Cherokee rose, 10-20 parts of radix rehmanniae recen, 8-12 parts of Fructus Corni, 10-20 parts of the fruit of glossy privet, 9-15 parts of safflower, Rhizoma Chuanxiong 10- 20 parts, 10-20 parts of Semen Cuscutae, 10-20 parts of radix achyranthis bidentatae, 9-15 parts of leech, 9-15 parts of pheretima, 2-4 parts of Radix Notoginseng, 6-12 parts of rheum officinale, Fu 10-20 parts of Siberian cocklebur, 20-40 parts of rhizoma alismatis, 20-40 parts of fleabane flower, 20-40 parts of gynostemma pentaphylla, 10-20 parts of tripterygium wilfordii, corn stigma 20-40 Part, 10-20 parts of Herba Euphorbiae Humifusae, 10-20 parts of turmeric, 20-40 parts of root of kirilow rhodiola.
2. the Chinese medicine for the treatment of diabetic nephropathy according to claim 1, it is characterized in that, it is mixed by the raw material of following parts by weight Conjunction is made：30 parts of Radix Astragali, 20 parts of Radix Angelicae Sinensis, 15 parts of Chinese yam, 30 parts of Radix Salviae Miltiorrhizae, 15 parts of Radix Codonopsis, 15 parts of radix paeoniae rubra, 15 parts of motherwort, Jin Ying Sub 30 parts, 15 parts of radix rehmanniae recen, 10 parts of Fructus Corni, 15 parts of the fruit of glossy privet, 12 parts of safflower, 15 parts of Rhizoma Chuanxiong, 15 parts of Semen Cuscutae, radix achyranthis bidentatae 15 Part, 12 parts of leech, 12 parts of pheretima, 3 parts of Radix Notoginseng, 9 parts of rheum officinale, 15 parts of Poria cocos, 30 parts of rhizoma alismatis, 30 parts of fleabane flower, 30 parts of gynostemma pentaphylla, 15 parts of tripterygium wilfordii, 30 parts of corn stigma, 15 parts of Herba Euphorbiae Humifusae, 15 parts of turmeric, 30 parts of root of kirilow rhodiola.
3. the Chinese medicine for the treatment of diabetic nephropathy according to claim 1 or 2, it is characterised in that：The Chinese medicine is capsule.
4. the preparation method of the Chinese medicine for the treatment of diabetic nephropathy according to claim 1, which is characterized in that including walking as follows Suddenly：（1）Each bulk pharmaceutical chemicals are weighed respectively, it is spare；（2）Take Chinese yam, Radix Salviae Miltiorrhizae, Radix Codonopsis, radix paeoniae rubra, the fruit of Cherokee rose, safflower, Semen Cuscutae, leech, Poria cocos, fleabane flower, Herba Euphorbiae Humifusae are uniformly mixed, and add water to cook twice, merge filtrate twice after filtrate is collected by filtration, are concentrated after cooling Compound A is obtained at powder at medicinal extract, then dries pulverizing；（3）Take Radix Astragali, Radix Angelicae Sinensis, motherwort, radix rehmanniae recen, Fructus Corni, the fruit of glossy privet, Rhizoma Chuanxiong, radix achyranthis bidentatae, pheretima, Radix Notoginseng, rheum officinale, rhizoma alismatis, gynostemma pentaphylla, tripterygium wilfordii, corn stigma, turmeric, root of kirilow rhodiola add ethyl alcohol to impregnate, and extract Twice, combined extract filters, is condensed into medicinal extract, and crushed after being dried obtains compound B；（4）Compound A and compound B are mixed It closes uniformly, capsule product is made in sterilization.
5. the preparation method of the Chinese medicine for the treatment of diabetic nephropathy according to claim 4, it is characterised in that：Step（2）In, In decocting twice, for the first time plus the water of three times weight is boiled by intense fire, is then cooked by slow fire 1 hour, filtrate and filter residue is collected by filtration； Into filter residue plus water regards no filter slag as criterion, and boils by intense fire, is then cooked by slow fire 30 minutes, filtrate is collected by filtration.
6. the preparation method of the Chinese medicine for the treatment of diabetic nephropathy according to claim 4, it is characterised in that：Step（2）With （3）In, the density of medicinal extract is that 1.1-1.2g/mL is ground into powder, obtains compound A after drying at 80 DEG C.
7. the preparation method of the Chinese medicine for the treatment of diabetic nephropathy according to claim 4, it is characterised in that：Step（3）In, Adding mass concentration is alcohol solution dipping 0.5-1.5 hours of 70%, is extracted twice, 1-2 hours each, combined extract.
8. the preparation method of the Chinese medicine for the treatment of diabetic nephropathy according to claim 4, it is characterised in that：Step（3）In, The relative density of medicinal extract is 1.2.
CN201811009506.3A 2018-08-31 2018-08-31 A kind of Chinese medicine and preparation method thereof for treating diabetic nephropathy Pending CN108853433A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113041324A (en) * 2021-04-27 2021-06-29 辽宁中医药大学 Traditional Chinese medicine composition for treating qi deficiency and blood stasis type diabetic nephropathy and preparation method thereof
CN113288998A (en) * 2020-02-21 2021-08-24 防城港济仁堂中医门诊部 Chinese medicinal formula for stabilizing blood sugar diseases and preparation scheme
CN115887608A (en) * 2022-11-30 2023-04-04 赵永芬 A kind of traditional Chinese medicine composition and preparation for treating type II diabetes and its complications

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113288998A (en) * 2020-02-21 2021-08-24 防城港济仁堂中医门诊部 Chinese medicinal formula for stabilizing blood sugar diseases and preparation scheme
CN113041324A (en) * 2021-04-27 2021-06-29 辽宁中医药大学 Traditional Chinese medicine composition for treating qi deficiency and blood stasis type diabetic nephropathy and preparation method thereof
CN115887608A (en) * 2022-11-30 2023-04-04 赵永芬 A kind of traditional Chinese medicine composition and preparation for treating type II diabetes and its complications

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