CN108852415A - It is a kind of through cranium three-dimensional cerebrovascular composite imaging method and system - Google Patents
It is a kind of through cranium three-dimensional cerebrovascular composite imaging method and system Download PDFInfo
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Abstract
This application discloses a kind of through cranium three-dimensional cerebrovascular composite imaging method and system, the method first with can the ring battle array of automatically scanning pop one's head in the ultrasonic signal different to encephalic different scanning position forward delay interval, so that ultrasonic signal focuses on the predetermined depth of wave beam axial direction, to be detected by focusing ultrasonic signal to intracranial cerebrovasculature, and digital delay focusing is carried out to the echo-signal received, to enhance echo-signal, raising gets cerebrovascular spatial shape and position precision, to improve the clarity and recall rate of three-dimensional cerebrovascular image.In addition, obtaining three-dimensional cerebrovascular image from different detecting locations, and compound to intracranial cerebrovasculature progress from multi-angle according to three-dimensional cerebrovascular image, the clarity of three-dimensional cerebrovascular image is further improved.Meanwhile having the characteristics that volume small frequency is low by ring battle array probe, so that it, which can be convenient, is worn on head, it can be achieved that 3-D scanning and long-time to intracranial cerebrovasculature monitor.
Description
Technical field
It is the present invention relates to IT and field of medical technology, in particular to a kind of through cranium three-dimensional cerebrovascular composite imaging method and to be
System.
Background technique
Cerebral apoplexy is the first factor for leading to Chinese's death.Patients with cerebrovascular disease is carried out using safely and effectively equipment
It diagnoses and screening is carried out to risk of stroke people at highest risk, there is urgent huge demand.Existing color Doppler ultrasonography in diagnosis is set
It is standby（TCCD）It is clear to the diagnostic image of intracranial vessel, high resolution, but due to skull to ultrasound huge decaying so that detection
Rate is low, and operation difficulty is big, strong to the dependence of personnel or equipment.Ultrasonic transcranial Doppler（TCD）Recall rate is high, but without two dimension
Image, operates as touch system, and Personnel Dependence is strong.DSA is the goldstandard of cerebrovascular disease detection, and CTA more often uses, but have radiation,
It is invasive, need contrast agent, be not suitable for repeated detection, and no blood dynamic data, clinical application has limitation, at high cost, is not suitable for
To continuous monitoring, curative effect evaluation and the regular follow-up of patients with cerebral apoplexy.
Thus the prior art could be improved and improve.
Summary of the invention
In view of the deficiencies of the prior art, the application will provide a kind of through cranium three-dimensional cerebrovascular composite imaging method and system,
With the advantage of TCCD and TCD, there are high imaging precision and penetrance, while it is strong to reduce Personnel Dependence.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is as follows：
It is a kind of through cranium three-dimensional cerebrovascular composite imaging method comprising：
Focusing ultrasonic wave scanning is carried out to encephalic from least two detecting locations respectively using the ring battle array probe of mechanical device control,
And receive the echo information of each detecting location；
Corresponding three-dimensional cerebrovascular spatial position figure is generated according to the corresponding echo information of each detecting location respectively；
Each three-dimensional cerebrovascular spatial position figure is compound according to its corresponding exploring sequence progress, to obtain three-dimensional cerebrovascular figure
Picture.
Beneficial effect：Compared with prior art, the present invention provides a kind of through cranium three-dimensional cerebrovascular composite imaging method and
System, the method first with can the ring battle array of automatically scanning pop one's head in the ultrasound different to encephalic different scanning position forward delay interval
Wave signal, so that the different ultrasonic signal that is delayed focuses on wave beam axially several predetermined depths, to pass through the focusing ultrasound
Wave signal detects intracranial cerebrovasculature, and it is poly- to carry out digital delay to the echo-signal of the ultrasonic signal received
Coke gets cerebrovascular spatial shape and position precision and signal strength so that echo-signal enhances to improve, to improve
The clarity and recall rate of three-dimensional cerebrovascular spatial position figure image.In addition, obtaining the three-dimensional cerebrovascular from different detecting locations
Spatial position figure, and it is compound to intracranial cerebrovasculature progress from multi-angle according to three-dimensional cerebrovascular spatial position figure, it further increases
The clarity of three-dimensional cerebrovascular image.In addition, having the characteristics that volume small frequency is low by ring battle array probe, so that it can
Head is worn on, it can be achieved that 3-D scanning and long-time to intracranial cerebrovasculature monitor to facilitate.
Detailed description of the invention
Fig. 1 is the flow chart of the embodiment one provided by the invention through cranium three-dimensional cerebrovascular composite imaging method.
Fig. 2 is that ultrasonic signal focuses in the embodiment one provided by the invention through cranium three-dimensional cerebrovascular composite imaging method
Schematic diagram.
Fig. 3 is time of ultrasonic signal in the embodiment one provided by the invention through cranium three-dimensional cerebrovascular composite imaging method
The focusing schematic diagram of wave signal.
Fig. 4 is that probe moving process shows in the embodiment one provided by the invention through cranium three-dimensional cerebrovascular composite imaging method
It is intended to.
Fig. 5 is the structure principle chart provided by the invention through cranium three-dimensional Cerebral vascular image system.
Fig. 6 is the structure principle chart provided by the invention through terminal device in cranium three-dimensional Cerebral vascular image system.
Specific embodiment
The present invention provide it is a kind of through cranium three-dimensional cerebrovascular composite imaging method and system, to make the purpose of the present invention, technology
Scheme and effect are clearer, clear, and the present invention is described in more detail as follows in conjunction with drawings and embodiments.It should manage
Solution, described herein specific examples are only used to explain the present invention, is not intended to limit the present invention.
Those skilled in the art of the present technique are appreciated that unless expressly stated, singular " one " used herein, " one
It is a ", " described " and "the" may also comprise plural form.It is to be further understood that being arranged used in specification of the invention
Diction " comprising " refer to that there are the feature, integer, step, operation, element and/or component, but it is not excluded that in the presence of or addition
Other one or more features, integer, step, operation, element, component and/or their group.It should be understood that when we claim member
Part is " connected " or when " coupled " to another element, it can be directly connected or coupled to other elements, or there may also be
Intermediary element.In addition, " connection " used herein or " coupling " may include being wirelessly connected or wirelessly coupling.It is used herein to arrange
Diction "and/or" includes one or more associated wholes for listing item or any cell and all combinations.
Those skilled in the art of the present technique are appreciated that unless otherwise defined, all terms used herein (including technology art
Language and scientific term), there is meaning identical with the general understanding of those of ordinary skill in fields of the present invention.Should also
Understand, those terms such as defined in the general dictionary, it should be understood that have in the context of the prior art
The consistent meaning of meaning, and unless idealization or meaning too formal otherwise will not be used by specific definitions as here
To explain.
With reference to the accompanying drawing, by the description of the embodiment, further explanation of the contents of the invention are made.
Embodiment one
This application provides a kind of through cranium three-dimensional cerebrovascular composite imaging method, as shown in Figure 1, the method includes：
S10, focusing ultrasonic wave is carried out to encephalic from least two detecting locations respectively using the ring battle array probe of mechanical device control
Scanning, and receive the echo information of each detecting location.
Specifically, the ring battle array probe of mechanical device control may include mechanical device and ring array transducer, described
The mechanical structure that mechanical device is used to that the ring battle array probe to be driven to swing, the ring array transducer is used for super to encephalic transmitting focusing
Acoustic signals, and focus the probe for receiving the ultrasonic signal echo-signal.In the present embodiment, the ring array transducer packet
Include several array element chips, several concentric circle best-fits of array element chip, and the area equation of each array element chip.For example, institute
Stating ring array transducer includes 5 array element chips, is denoted as the first array element chip respectively, the second array element chip, third array element chip, the
Four array element chips and the 5th array element chip.The first array element chip, the second array element chip, third array element chip, the 4th gust
First chip and the 5th array element chip successively press concentric circular fashion arrangement, wherein and the first array element chip is circle, and first gust
The center of circle of first chip is the center of circle of concentric circles, and it is peripheral and same with the first array element chip that the second array element chip is located at the first array element chip
The heart, third array element chip is peripheral and concentric with the second array element chip positioned at the second array element chip, and the 4th array element chip is located at third
Array element chip periphery is simultaneously concentric with third array element chip, the 5th array element chip be located at the 4th array element chip periphery and with the 4th array element
Chip is concentric, and the first array element chip, the second array element chip, third array element chip, the 4th array element chip and the 5th array element
The area equation of chip.In addition, when the diameter that the ring battle array that 5 array element chips are constituted is popped one's head in is 15mm, in depth bounds
Beam diameter to be formed in the range of 20mm to 100mm can be 2mm to 3.5mm, wherein the diameter is 5 that 15mm refers to
The outer diameter for the same thimble battle array that a array element chip is constituted.Relative to existing TCD probe be single-chip, frequency be 1.6MHz extremely
2.0MHz, the focal point diameter of beam direction within the scope of 20mm to 100mm（Lateral resolution）For 6mm, 4.5mm（- 6dB band
It is wide）, it is 10mm or more in the resolution ratio of proximal end or distal end, the ring battle array probe of the application is 1.6MHz to 2.0MHz in frequency,
Beam diameter changes within the scope of 2mm to 3.5mm in the range of depth bounds are 20mm to 100mm, and about the 1/3 of TCD, thus
Under same low frequency/same depth profile, the ultrasound of the diameter ratio TCD probe transmitting of the ultrasonic wave of ring battle array probe transmitting
Wave diameter is much smaller, so as to improve three-dimensional cerebrovascular precision.
Simultaneously in the present embodiment, the mechanical device can two stepper motors and two connecting rods, the connection
One end of bar is connected with ring array transducer, the other end be connected with stepper motor and with stepper motor eccentric setting, the step
The link motion is driven into motor, the connecting rod drives energy converter rotation within the scope of predetermined angle, thus realization pair
The cerebrovascular of encephalic is scanned.In practical applications, ring battle array probe may include probe cassette, the ring array transducer with
And the mechanical device is assemblied in the probe cassette, the probe cassette is fixed on a frame, and will be visited by the head frame
Head cartridge band is in testee head, so that the ring array transducer is in contact with head.In addition, in the deformation implementation of the present embodiment
In example, the mechanical device can also be mechanical arm, and the ring array transducer is connected with the mechanical arm, and passes through the machine
Tool arm controls the ring array transducer and is in contact with head, and drive the ring array transducer within the scope of predetermined angle rotation or
Person moves within a preset range.In the following illustration by taking stepper motor is machine control unit as an example.
In addition, the detecting location refers to that ring battle array probe carries out the position of ultrasonic scanning, and the ring to encephalic
Battle array probe can be swung in each detecting location according to desired guiding trajectory, to obtain the echo letter of preset quantity in the detecting location
Breath.That is, each detecting location includes several scan position, ring battle array probe sends encephalic in first each scan position
Ultrasonic signal, and according to the echo data of the echo-signal of the ultrasonic signal the first scan position of acquisition, passing through later
Mechanical device control is rocked to the second scan position, sends ultrasonic signal in the second scan position to obtain the second scan position
Echo data, and so on until all scan positions are completed on default swinging track, it is available in this way to the first detection
The corresponding all echo informations in position.After getting all echo informations of the first detecting location, the probe movement of control ring battle array
To the second detecting location, and the process for swinging and scanning according to desired guiding trajectory is repeated, to obtain the echo of the second detecting location
Information, and so on until completing all detecting locations.Correspondingly, it is described using mechanical device control ring battle array probe respectively from
At least two detecting locations carry out focusing ultrasonic wave scanning to encephalic, and the echo-signal for receiving each detecting location specifically includes：
S11, ring battle array probe is placed in the first detecting location, is put by mechanical device control ring battle array probe according to default swinging track
It is dynamic, and obtain the echo information of the corresponding preset quantity of the first detecting location.
Specifically, the default swinging track is to preset, and the ring battle array probe is controlled by mechanical device according to institute
Default swinging track is stated to be swung.Also, ring battle array probe stops during the swing according to preset condition with each scanning of determination
Position, and encephalic is being scanned to scan position.The preset condition can be every swing predetermined angle, for example, 0.6 °
Deng.That is, ring battle array probe, according to default swinging track, every swing predetermined angle stops and sends ultrasonic wave letter to encephalic
Number, and receive the echo-signal of the ultrasonic signal.
Illustratively, it is described by ring battle array probe be placed in the first detecting location, by mechanical device control ring battle array probe according to
Default swinging track is swung, and the echo information for obtaining the corresponding preset quantity of the first detecting location specifically includes：
S111, ring battle array probe is placed in the first scan position of the first detecting location, each array element of control ring battle array probe is to default
The first different ultrasonic signal of depth bounds forward delay interval, so that first ultrasonic signal focuses upwards in beam axis
In the predetermined depth range；
S112, the first echo signal for receiving first ultrasonic signal, and in the first echo for being in predetermined depth range
The first echo information of the first preset quantity is extracted in signal；
S113, control ring battle array probe by mechanical device and swing predetermined angle by desired guiding trajectory, forward delay interval it is different the
Two ultrasonic signals are to obtain the second echo information of the first preset quantity；
S114, successively control ring battle array probe are swung according to desired guiding trajectory until moving terminates, to obtain pair of the first detecting location
The echo information for the preset quantity answered.
Specifically, in the step S111, first scan position is that ring battle array probe is worn on by head frame
When the first detecting location, the position that ring battle array probe is in contact with head, first scan position is that ring battle array is popped one's head in the first spy
Location sets the position of start-up operation.In the present embodiment, the first spy can be set by the first scan position of the first detecting location
Other scan positions that the base position that location is set, i.e. the first detecting location include are reference with the base position.For example, with
First scan position is that origin establishes coordinate system, is respectively swept according to the motion profile of ring battle array probe and preset condition to determine
The positional relationship of the position of described point and the first scan position, and determine that it is being with the first scan position according to the positional relationship
Coordinate in the coordinate system of origin, and pass through the position of its corresponding scanning element of the coordinate record, thus each scan position
Location information may make up two-dimensional array.
In addition, as shown in Fig. 2, due to the concentric circle arrangement of each array element chip of ring battle array probe, then each array element chip reaches
The distance of predetermined depth is different, and the corresponding time for reaching pre-determined distance is also different, so as to according to each array element chip and in advance
If the distance between depth and ultrasonic wave are arrived in the spread speed of encephalic come the ultrasonic signal for determining that each array element chip is formed
Up to the time of predetermined depth, the corresponding delay time of each array element chip is determined according to each time, so that each battle array of ring battle array probe
The ultrasonic signal that first chip is formed is focused in predetermined depth, so that focusing ultrasonic wave.
Further, in order to improve ultrasonic wave echo-signal accuracy, to predetermined depth range send ultrasonic wave letter
Number when, can using segmentation send by the way of.The predetermined depth range is divided into several sub- depth bounds, respectively to each
Sub- depth bounds send ultrasonic signal, to obtain the echo-signal of each sub- depth bounds, finally according to each sub- depth bounds
Echo-signal obtains the echo-signal of predetermined depth range.Correspondingly, described be placed in the of the first detecting location for ring battle array probe
One scan position, each array element of control ring battle array probe first ultrasonic signal different to predetermined depth range forward delay interval, with
It is specifically included so that first ultrasonic signal focuses on the predetermined depth range in beam axis upwards：
S1111, the corresponding predetermined depth range of the first scan position for obtaining first detecting location, and by the default depth
Degree range is divided into several sub- depth bounds；
S1112, control ring battle array probe each array element to successively to each sub- depth bounds forward delay interval it is different the first ultrasonic wave letter
Number, so that the first ultrasonic signal focuses on each sub- depth bounds in beam axis respectively upwards.
Specifically, the predetermined depth range can using etc. grading modes divided, to obtain several sub- depth models
It encloses.It, can be by several sub- depth bounds according to its corresponding depth liter and after division obtains several sub- depth bounds
Sequence sequence, to obtain sub- depth bounds sequence.Meanwhile each array element of control ring battle array probe first is respectively to the first sub- depth bounds
The first different sub- ultrasonic signal of forward delay interval receives the first sub- echo-signal of the first sub- ultrasonic signal；It controls again
Each array element of ring battle array processed probe second sub- ultrasonic signal different to the second sub- depth bounds forward delay interval respectively, described in reception
Second sub- echo-signal of the second sub- ultrasonic signal, and so on until send ultrasonic signal to the sub- depth bounds,
Finally the of the corresponding first preset data amount of the first scan position is extracted according to the corresponding echo-signal of each sub- depth bounds
One echo data.In the present embodiment, several sub- depth bounds are obtained in such a way that predetermined depth range is drawn equal part（Example
Such as, 5 sub- depth bounds etc.）, and the quantity of several sub- depth bounds is obtained, then determine first preset quantity and institute
It states the quotient of quantity, and extracts the quotient echo data in the corresponding echo-signal of every sub- depth bounds.Certainly, first
When preset quantity can not divide exactly quantity, quotient+remainder echo data can be chosen with any sub- depth bounds.Wherein, described several
The quantity of sub- depth bounds is preferably the factor of the first preset quantity, the quantity can be allowed to divide exactly described first in this way
Preset data.In addition, should illustrate, for each scan position in predetermined movement track, can be scanned using with first
The identical collection process of the process of position.
In addition, can surpass repeating to send to each sub- depth bounds after having sent ultrasonic signal to each sub- depth bounds
The operation of acoustic signals, to obtain the corresponding echo-signal of multiple predetermined depth ranges, and it is compound according to multiple echo-signals
Obtain the echo-signal of each scan position.It meanwhile by the way that it is available repeatedly to send ultrasonic signal not being different time points
Echo data forms echo data stream according to the determination of the echo data of different time points, so as to be formed according to echo data
Doppler frequency spectrum.Correspondingly, first scan position that ring battle array probe is placed in the first detecting location, control ring battle array probe
Each array element first ultrasonic signal different to predetermined depth range forward delay interval, so that first ultrasonic signal is in wave
The predetermined depth range is focused in beam axial direction is specially：Ring battle array probe is placed in the first scanning position of the first detecting location
It sets, each array element of control ring battle array probe sends multi beam to predetermined depth range within a preset time and is delayed the first different ultrasonic waves
Signal, so that first ultrasonic signal focuses on the predetermined depth range in beam axis upwards.It can be improved in this way
The accuracy of the echo information of first preset data.
Further, in the step S112, the ring battle array probe can focus the echo-signal of received ultrasonic signal,
And the data point of the first preset quantity is chosen in the focused echo signal within the scope of predetermined depth as echo data.Accordingly
, the first echo signal for receiving first ultrasonic signal, and extract the first preset quantity of first echo signal
The first echo data specifically include:
S1121, the first echo signal for receiving first ultrasonic signal, and be delayed and exported according to default focusing delay time
The first echo signal is to obtain focused echo signal；
S1122, the focused echo signal is amplified into filtering, filtered focused echo signal is converted into digital letter
Number, and the first echo data according to the digital signal the first preset quantity of acquisition.
Specifically, as shown in figure 3, ring battle array probe receives the echo-signal of the first ultrasonic signal, by what is received
Echo-signal is converted to electric signal, amplifies filtering processing to electric signal, then the electric signal after amplification filtering processing is passed through
Digital-to-analogue conversion is at digital signal, and each array element chip carries out delay output according to the default focusing delay time, and uses adder
It sums and is added to the postpones signal of output, make to enhance from focus and the echo-signal of near focal point, returning other than focal zone
Wave signal mutually weakens so that offsetting, to reach collectiong focusing echo-signal.In addition, being converted to number in focused echo signal
Signal can choose the data point of the first preset quantity in digital signal, by the data point for the first preset quantity chosen
The echo data of the first preset quantity as the first ultrasonic signal, wherein the depth of the echo data of each first preset quantity
Degree belongs within the scope of predetermined depth.In the present embodiment, the predetermined depth range is pre-set, for example, 20mm is extremely
100mm etc..First preset quantity is to preset, for example, 128 etc..
In addition, the first echo signal for receiving first ultrasonic signal, and extract the of first echo signal
First echo data of one preset quantity specifically includes：
S1121a, the first echo information for receiving each first ultrasonic signal, and the first of each first echo signal is extracted respectively
First echo data of preset quantity, wherein the depth of corresponding first echo data is corresponding in each first echo signal；
A1122b, operation is carried out to corresponding first echo data of same depth difference first echo signal respectively, it is each to obtain
Corresponding first echo data of depth, to obtain the first echo data of corresponding first preset quantity of the first ultrasonic signal.
Specifically, ring battle array probe, which receives, amplifies the processing such as filtering line number mould of going forward side by side after signal and is converted to number
Signal, the echo data for receiving the first preset data on wave beam can be obtained by handling digital signal.In same scanning position
Transmitting multiple pulses are set, every subpulse obtains the echo data of the first preset quantity, wherein the corresponding detection of each echo data is deep
Degree.That is, each investigation depth gets multiple echo datas, multiple echo datas of each investigation depth are carried out certainly
Related operation or fast Fourier（FFT）Operation, to obtain the corresponding echo data of each investigation depth.
Further, in the step S113, the default swinging track and default swing angle（For example, 0.6 ° etc.）
Be to preset, ring battle array probe is swung according to the default swinging track, and it is every swing carry out after default swing angle according to
Secondary ultrasonic wave transmitting and echo signal reception.
In order to which the collection process of echo data is described in detail, it is illustrated here with two specific examples.For example, described pre-
If swinging track is " returning " font, two stepper motors being connected in probe cassette with ring array transducer（It is denoted as the first step respectively
Into motor and second stepper motor）It can control ring energy energy converter and reach full swing angle, wherein the first stepper motor control
Ring array transducer processed is rocked to full swing angle along the first preset direction（For example, unilateral 11.5 °）, second stepper motor control
Ring array transducer is rocked to full swing angle along the second preset direction, and it is pre- that second preset direction is preferably normal to first
The direction of set direction.After ring array transducer scans through the first scan position, first component motor is along the first preset direction maximum
Swing angle successively swings default swing angle and stops at the position after swinging, and recurrence of laying equal stress on send ultrasonic wave and receives ultrasound
The step of echo-signal of wave, continues to swing along the first preset direction pre- after the echo data for getting the first preset quantity
If swing angle is until ring array transducer reaches full swing angle, to get the first quantity echo on the first plane
Data；Then second stepper motor control ring array transducer swings default swing angle along the second preset direction, and executes repetition
The step of sending ultrasonic wave and receiving the echo-signal of ultrasonic wave, after the echo data for getting the first preset quantity, the
One stepper motor repeats the above process, and from current location along backswing to full swing angle, obtains the of second plane
One quantity echo data；And so on until second stepper motor movement reaches maximum deflection angle, and the first stepping electricity
Machine repeats above-mentioned stepping process to obtain the first data strip echo data of each screen of the second quantity, and acquisition first accumulative in this way counts
The * the second quantity ultrasonic echo data is measured, to obtain returning for space the first preset quantity * the first quantity * the second quantity point
Wave number evidence.Certainly, in other embodiments of the invention, the ring battle array probe can also be scanned according to other tracks, example
Such as, linear scan, sectoring, rotary scanning, Back Word type scanning etc..For another example, the first stepper motor and second stepper motor are 0
Degree is first ultrasonic beam echo data of acquisition, then controls the first stepper motor and second component motor is swung, so that super
Beam of sound carries out circular scanning centered on first ultrasonic beam position, obtains M1 scan line, gradually expands circle diameter,
Until obtaining Mn scan line.It is accumulative in this way to obtain M1+M2+ ...+Mn line, to obtain space the first preset quantity *（M1+
M2+…+Mn）The data of a point.
S12, control ring battle array probe are moved to the second detecting location, and Repetitive controller ring battle array probe swings and obtain echo letter
The operation of breath is until ring battle array probe is moved to each detecting location, to obtain the echo information of each detecting location.
Specifically, as shown in figure 4, second detecting location can be and preset, be also possible to ring battle array probe according to
Default motion track and default mobile condition are moved and are formed.Wherein, the default motion track is circumferentially to move, and is preset
Mobile condition can be mobile 3cm etc..That is, ring battle array probe is after the first detecting location completes scanning, it is mobile second
Detecting location, and repeat the operation that the first detecting location executes in the second detecting location, i.e., in the second detecting location control ring battle array
Probe swings according to default swinging track and is scanned in each scan position, to obtain the corresponding echo letter of the second detecting location
Breath.And so on until completing the scanning of all detecting locations.In addition, the corresponding default swinging track of each detecting location can phase
With can also be different, in the present embodiment, each detecting location corresponding default swinging track and comprising each scan position
Generation type is all the same.The compound accuracy of the cerebrovascular can be improved in this way.
S20, corresponding three-dimensional cerebrovascular spatial position figure generated according to the corresponding echo information of each detecting location respectively.
Specifically, the echo-signal that the echo-signal can be formed for encephalic different material, and different substance shapes
At echo-signal it is different, to determine that the corresponding echo-signal of the cerebrovascular and brain blood flow are corresponding according to echo-signal is received
Echo-signal, in this way it is available arrive cerebrovascular echo-signal.It is returned getting the corresponding all cerebrovasculars of each detecting location
Wave information and it includes each scan positions, can be generated the corresponding cerebrovascular spatial position figure of each detecting location.That is,
All scan positions for including according to each detecting location, each scan position are relative to the swing angle of the first scan position and pre-
If depth bounds can determine each cerebrovascular spatial position, and then generate each cerebrovascular spatial position figure.In addition, generating
When the figure of cerebrovascular spatial position, brain blood flow information can also be determined according to echo information, and three-dimensional brain is generated according to brain blood flow information
Blood-stream image and the three-dimensional cerebrovascular image for carrying brain blood flow information.Wherein, cerebrovascular spatial position figure is encephalic brain blood
The image of pipe, corresponding brain blood flow information is not configured in the cerebrovascular image, and the rheoencephalogram picture is in intracranial cerebrovasculature
The image that is formed of blood flow information, the cerebrovascular image for carrying brain blood flow information is to match in cerebrovascular image and the cerebrovascular
Set corresponding rheoencephalogram picture.
Further, the brain blood flow information may include grayscale, blood flow velocity and blood flow direction, according to the acquisition
To the corresponding brain blood flow data of echo data of first the second preset quantity of preset quantity *, can be obtained by three-dimensional imaging algorithm
To encephalic brain blood flow 3-D image.The cerebrovascular 3-D image may include cerebrovascular form and the mutual position between the cerebrovascular
It sets, wherein cerebrovascular form may include cerebrovascular location information, shape information and dimension information etc..The carrying brain
The cerebrovascular 3-D image of blood flow information includes cerebrovascular form and corresponding haemodynamics information, wherein the blood flow
Dynamic information can determine that mutual alignment can between the cerebrovascular form and the cerebrovascular according to blood flow velocity and energy value
To carry out three-dimensional blood vessel according to echo data（Blood flow）It rebuilds, then carries out three-dimensional image segmentation and extracted three-dimensional blood vessel, finally lead to
It crosses three dimensional reconstructive CT and obtains cerebrovascular 3-D image.Wherein, the three dimensional reconstructive CT can using sampling filter algorithm,
Real-time imaging and three-dimensional are rebuild in FFT transform, Hilbert transform, auto-correlation computation, interpolation algorithm, the parallelization based on GPU
Blood flow divides extractive technique etc..
Simultaneously in embodiment, the cerebrovascular three-dimensional cerebrovascular and/or and rheoencephalogram picture can be three-dimensional gray-scale figure
Picture is also possible to three-dimensional color image.It is described to be generated according to the brain blood flow information when described image is three-dimensional gray scale image
The three-dimensional cerebrovascular and/or and rheoencephalogram picture may include：The location information of each scan position is extracted, and according to location information pair
The echo-signal answered obtains the location information and corresponds to brain blood flow information, wherein the brain blood flow information includes at least blood flow side
To, blood flow velocity；According to the positional information and the location information corresponds to brain blood flow information and generates the encephalic three-dimensional cerebrovascular
And/or and rheoencephalogram picture.Wherein, specifically, the three-dimensional cerebrovascular and/or and rheoencephalogram seem by three-dimensional reconstruction at
It obtains, the three-dimensional reconstruction algorithm can use Bezier D interpolation algorithm.
In addition, when described image is three-dimensional color image, according to the brain blood flow information generate the three-dimensional cerebrovascular and/or
And rheoencephalogram picture may include：The location information of each scan position is extracted, and is obtained according to the corresponding echo-signal of location information
The location information is taken to correspond to brain blood flow information, wherein the brain blood flow information includes at least blood flow velocity and grayscale is believed
Breath；According to the positional information and the location information corresponds to brain blood flow information and generates three-dimensional cerebrovascular gray scale image.Wherein,
It can will be according to corresponding space bit confidence according to the echo data got, its corresponding scan position and scan depths
Breath, the corresponding two dimensional image of each echo data is mapped in said three-dimensional body, is then obtained continuously using three-dimensional interpolation algorithm for reconstructing
Complete three-dimensional gray-scale figure.Wherein, what the three-dimensional gray-scale figure did not carried no blood direction is just gray scale image, and when three-dimensional
When gray-scale figure divides section display by interface, available B ultrasound image.In practical applications, three-dimensional gray-scale figure can be thin
Thin vessels are unobvious or in the case that minute blood vessel is filtered out, and can pass through the bright-dark degree of different gray scale colors and assist doctor
It is raw to carry out clinical analysis.
S30, each three-dimensional cerebrovascular spatial position figure is carried out according to its corresponding exploring sequence it is compound, to obtain three-dimensional brain
Blood-vessel image.
Specifically, the exploring sequence is the sequence that each detecting location is detected in time.The exploring sequence can be with
It is determined according to the mobile sequence of ring battle array probe.For example, as described in Figure 4, the ring battle array detection is successively moved to D point from A point, and
And A point to D point is detecting location, then the exploring sequence of A point to D point is A point, B point, C point and D point.Correspondingly, described
Each three-dimensional cerebrovascular spatial position figure is compound according to its corresponding exploring sequence progress, it is specific to obtain three-dimensional cerebrovascular image
May include：
S31, the mobile sequence for obtaining ring battle array probe, and according to the mobile exploring sequence for sequentially obtaining each detecting location；
S32, the composite sequence that each three-dimensional cerebrovascular spatial position figure is determined according to the exploring sequence, and according to described compound suitable
Sequence is compound by each three-dimensional vascular space location drawing progress, to generate three-dimensional cerebrovascular image.
Specifically, described to carry out compound referring to be in first by each three-dimensional vascular space location drawing according to composite sequence
Each three-dimensional vascular space location drawing is successively carried out according to composite sequence it is compound, i.e., first by the three-dimensional blood vessel of the first composite sequence
The progress of the three-dimensional vascular space location drawing of spatial position figure and the second composite sequence is compound to obtain the first three-dimensional blood-vessel image, then
The three-dimensional vascular space location drawing of first three-dimensional blood-vessel image and third composite sequence is carried out compound to obtain the second three-dimensional blood vessel
Image, and so on until completing the compound of all three-dimensional vascular space locations drawing.
It is with each preset reference point for reference to progress, institute in addition, carrying out compound tense in the three-dimensional vascular space location drawing
Preset reference point is stated to obtain by ring battle array probe.Ring battle array probe includes two probes, and two probes simultaneously with head phase
Contact（For example, being respectively placed in head or so temporo window position）And ultrasonic scanning is carried out simultaneously, in this way according to two ring battle array transducings
The available head of device or so center, it is here that the head or so center is as a reference point.Correspondingly, described according to the spy
Survey sequence determines the composite sequence of each three-dimensional cerebrovascular spatial position figure, and according to the composite sequence by each three-dimensional vascular space
Location drawing progress is compound, is specifically included with generating three-dimensional cerebrovascular image：
The position that S321, the left and right for obtaining the ring battle array probe are popped one's head in, and determine that encephalic is joined according to the position of the left and right probe
Examination point；
S322, using the reference point as foundation, each three-dimensional vascular space location drawing is carried out according to composite sequence it is compound, to generate
Three-dimensional blood-vessel image.
Embodiment two
It present embodiments provides a kind of through cranium three-dimensional cerebrovascular composite imaging method, the imaging process phase of this implementation and embodiment one
Together, the difference is that ring battle array probe for each scan position echo data acquisition collection process, thus ring battle array here
It pops one's head in and the acquisition collection process of the echo data of each scan position is described in detail.The ring battle array probe data collection process tool
Body may include：
A, head angle and scan depths are adjusted according to default swinging track, and sends multi beam to encephalic in scan position and focus and surpasses
Acoustic signals receive the echo-signal of multi beam ultrasonic signal and the echo of writing scan position and each scan depths letter respectively
Number；
B, multi beam ultrasonic signal is sent in the scan position and receive the echo-signal of repeated ultrasonic wave signal, and retain institute
State the strongest echo-signal of scan position；
C, according to scan position and each scan depths to the corresponding vessel position of a each echo-signal, ring battle array probe is swung the
One head angle, and institute is completed until head angle all in head angle sequence is capped in the step of repeating step B
The acquisition of scan position is stated, and ring battle array probe is rocked to next scan position and step A-C until completing default swinging track.
Specifically, the ring battle array, which is popped one's head in, issues ultrasonic signal to the cerebrovascular of the corresponding encephalic of scan position, receives super
The echo-signal of acoustic signals simultaneously extracts the echo data of the first preset quantity in the echo-signal, default according to described first
The echo data of quantity corresponding time point determines the corresponding investigation depth of each echo data, to obtain the corresponding spy of scan position
Depth measurement degree set.For the first investigation depth in investigation depth set, rotation ring battle array first is popped one's head in the first predetermined angle, and
Think that first investigation depth sends ultrasonic signal, and the current echo-signal for obtaining the ultrasonic signal works as pre-echo
Signal strength；If current echo signal intensity is greater than stored echo signal intensity, using current echo signal intensity and
Its is corresponding when the front ring battle array head angle stored echo signal intensity of update and its corresponding ring battle array head angle, until
After all head angles are capped in default head angle sequence, the second investigation depth of investigation depth set is repeated
Process is stated until all investigation depths in the investigation depth set are capped.According to default swinging track and default swing
Angle swinging ring battle array is popped one's head in next scanning element.For example, after the investigation depth of ring battle array probe determines, it is available in the longitudinal direction
The haemodynamics information of continuous depth；Probe deflection angle is accurately adjusted using mechanical structure, when scanning is to first, is obtained
The echo-signal for taking at first point, in the deflection angle popped one's head in by ring battle array, depth calculation is to first point of corresponding spatial position；Cause
To be spherical swivel, deflection angle can form cone in space, so as to measure the location information of vessel cross-sections；Again by ring
Battle array is swung when second point is scanned, and obtains the echo-signal of second point；Deflection angle reaches thirdly again, obtains thirdly
Echo-signal, so as to according to first point, second point and thirdly put and determine echo-signal point of maximum intensity and blood vessel side
Boundary's location information；Haemodynamics information can be equally got in other orientation simultaneously, thus one section of blood vessel range of composition
Vasokinetic information.Again by adjusting depth of probe, then obtain different depth range echo-signal it is available corresponding
Brain blood flow information calculates blood vessel three-dimensional space position and size by vessel position, is calculated by blood flow velocity, energy value
Vascular flow form.Certainly, multi beam ultrasonic pulse can be sent for each investigation depth, according to multi beam ultrasonic pulse
Echo-signal determine the echo data of the position, this process in example 1 it is stated that just do not repeating here.
It further, can real-time reception current probe angle while obtaining head angle and pressing head angle sequence scanning
Corresponding current echo-signal is spent, and obtains the corresponding current echo signal intensity of current echo-signal in real time, according to setting in advance
The echo signal intensity section set-signal display color list judges the signal display color of current echo signal intensity, and
Real-time display is carried out on the corresponding display point of preset display screen.Certainly, in practical applications, echo-signal can be divided in advance
Intensity interval, and echo signal intensity section and color progress is equally corresponding, when signal strength belongs to the echo signal intensity
When section, set the color of the echo-signal to the corresponding color in signal strength section.For example, presetting echo
Signal strength section-signal display color list, wherein wrapped in the echo signal intensity section-signal display color list
First echo signal intensity interval, second echo signal intensity interval and third echo signal intensity section are included, with the first echo
The corresponding black signal in signal strength section show color, blue signal corresponding with second echo signal intensity interval display color and
Danger signal corresponding with third echo signal intensity section shows color.It is so current time corresponding when receiving current probe angle
When wave signal, the corresponding current echo signal intensity of current echo-signal is obtained, and by current echo signal intensity and described time
Wave signal strength section-signal display color list is matched；If it is strong that current echo signal intensity is in first echo signal
Section is spent, then corresponding display point is shown on a display screen with black；If current echo signal intensity is in the second echo
Signal strength section, then corresponding display point is shown on a display screen with blue；If current echo signal intensity is in the
Three echo signal intensity sections, then corresponding display point is shown on a display screen with red.
Based on above-mentioned through cranium three-dimensional cerebrovascular composite imaging method, the present invention also provides it is a kind of through the cranium three-dimensional cerebrovascular at
As system, as shown in Figure 5 comprising ring battle array probe 100 and control device 200, the ring battle array probe is for passing through mechanical dress
It sets control and focusing ultrasonic wave scanning is carried out to encephalic, receive the echo-signal of each scan position；The control device for realizing
As described above through the step in cranium three-dimensional cerebrovascular composite imaging method.
In through cranium three-dimensional Cerebral vascular image system, the control device include through cranium processing unit and terminal device,
It is described through cranium processing unit connection ring battle array probe and terminal device, it is described to be used to believe the control of terminal device through cranium processing unit
Number it is sent to ring battle array probe, and the echo-signal of storage ring battle array probe acquisition.
In through cranium three-dimensional cerebrovascular complex imaging system, as shown in fig. 6, the terminal device includes at least one processing
Device（processor）20；Display screen 21；And memory（memory）22, it can also include communication interface
（Communications Interface）23 and bus 24.Wherein, processor 20, display screen 21, memory 22 and communication connect
Mouth 23 can complete mutual communication by bus 24.Display screen 21 is set as preset user in display initial setting mode
Guide interface.Communication interface 23 can transmit information.Processor 20 can call the logical order in memory 22, on executing
State the method in embodiment.
In addition, the logical order in above-mentioned memory 22 can be realized and as only by way of SFU software functional unit
Vertical product when selling or using, can store in a computer readable storage medium.
Memory 22 is used as a kind of computer readable storage medium, and it is executable to may be configured as storage software program, computer
Program, such as the corresponding program instruction of method or module in the embodiment of the present disclosure.Processor 30 is stored in memory by operation
Software program, instruction or module in 22, thereby executing functional application and data processing, i.e. side in realization above-described embodiment
Method.
Memory 22 may include storing program area and storage data area, wherein storing program area can storage program area, extremely
Application program needed for a few function；Storage data area, which can be stored, uses created data etc. according to terminal device.This
Outside, memory 22 may include high-speed random access memory, can also include nonvolatile memory.For example, USB flash disk, movement
Hard disk, read-only memory (Read-Only Memory, ROM), random access memory (Random Access Memory,
RAM), a variety of media that can store program code such as magnetic or disk, are also possible to transitory memory medium.
In addition, a plurality of instruction processing unit in above-mentioned storage medium and mobile terminal loads and the detailed process executed exists
It has been described in detail in the above method, has just no longer stated one by one herein.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that：It still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；
And these are modified or replaceed, technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution spirit and
Range.
Claims (10)
1. a kind of through cranium three-dimensional cerebrovascular composite imaging method, which is characterized in that it includes：
Focusing ultrasonic wave scanning is carried out to encephalic from least two detecting locations respectively using the ring battle array probe of mechanical device control,
And receive the echo information of each detecting location；
Corresponding three-dimensional cerebrovascular spatial position figure is generated according to the corresponding echo information of each detecting location respectively；
Each three-dimensional cerebrovascular spatial position figure is compound according to its corresponding exploring sequence progress, to obtain three-dimensional cerebrovascular figure
Picture.
2. according to claim 1 through cranium three-dimensional cerebrovascular composite imaging method, which is characterized in that the mechanical device control
Ring battle array probe for the automatic ring battle array probe that is controlled by steering engine and connecting rod or by one of the ring battle array probe of mechanical arm control.
3. according to claim 1 through cranium three-dimensional cerebrovascular composite imaging method, which is characterized in that described to utilize mechanical device
The ring battle array probe of control carries out focusing ultrasonic wave scanning to encephalic from least two detecting locations respectively, and receives each detecting location
Echo-signal：
Ring battle array probe is placed in the first detecting location, is swung by mechanical device control ring battle array probe according to default swinging track,
And obtain the echo information of the corresponding preset quantity of the first detecting location；
Control ring battle array probe is moved to the second detecting location, and Repetitive controller ring battle array probe swings and obtain the operation of echo information
Until ring battle array probe is moved to each detecting location, to obtain the echo information of each detecting location.
4. according to claim 3 through cranium three-dimensional cerebrovascular composite imaging method, which is characterized in that described to set ring battle array probe
In the first detecting location, swung by mechanical device control ring battle array probe according to default swinging track, and obtain the first detection position
The echo information for setting corresponding preset quantity specifically includes：
Ring battle array probe is placed in the first scan position of the first detecting location, each array element of control ring battle array probe is to predetermined depth model
Enclose the first different ultrasonic signal of forward delay interval so that first ultrasonic signal focused on upwards in beam axis it is described
Predetermined depth range；
The first echo signal of first ultrasonic signal is received, and in the first echo signal in predetermined depth range
Extract the first echo information of the first preset quantity；
The ring battle array probe, which is controlled, by mechanical device swings predetermined angle, the second different ultrasound of forward delay interval by desired guiding trajectory
Wave signal is to obtain the second echo information of the first preset quantity；
Successively control ring battle array probe swings according to desired guiding trajectory and terminates up to moving, corresponding default to obtain the first detecting location
The echo information of quantity.
5. according to claim 4 through cranium three-dimensional cerebrovascular composite imaging method, which is characterized in that described to set ring battle array probe
It is different to predetermined depth range forward delay interval in each array element of the first scan position of the first detecting location, control ring battle array probe
First ultrasonic signal, so that in beam axis to focus on the predetermined depth range upwards specific for first ultrasonic signal
Including：
Obtain the corresponding predetermined depth range of the first scan position of first detecting location, and by the predetermined depth range
It is divided into several sub- depth bounds；
Control ring battle array probe each array element to the first successively different to each sub- depth bounds forward delay interval ultrasonic signals so that
It obtains the first ultrasonic signal and focuses on each sub- depth bounds upwards in beam axis respectively.
6. according to claim 4 or 5 through cranium three-dimensional cerebrovascular composite imaging method, which is characterized in that described to visit ring battle array
Head is placed in the first scan position of the first detecting location, each array element of control ring battle array probe to predetermined depth range forward delay interval not
The first same ultrasonic signal, so that first ultrasonic signal focuses on the predetermined depth range in beam axis upwards
Specially：
Ring battle array probe is placed in the first scan position of the first detecting location, each array element of control ring battle array probe is within a preset time
It sends multi beam to predetermined depth range to be delayed the first different ultrasonic signals, so that first ultrasonic signal is in wave beam
The predetermined depth range is focused in axial direction.
7. according to claim 6 through cranium three-dimensional cerebrovascular composite imaging method, which is characterized in that described to receive described first
The first echo signal of ultrasonic signal, and the first preset quantity is extracted in the first echo signal in predetermined depth range
The first echo data specifically include：
Each first echo signal of each the first ultrasonic signal of beam is successively received, and according to the collectiong focusing delay time of each array element
Delay output accumulating operation is carried out to each first echo information, to obtain the corresponding focused echo letter of each the first ultrasonic signal of beam
Number；
Obtain the first echo data of the first preset quantity according to each focused echo signal, and to each focused echo signal into
Row screening forms spectrum information to obtain the corresponding echo information of the first scan position, and according to each focused echo signal.
8. according to claim 1 through cranium three-dimensional cerebrovascular composite imaging method, which is characterized in that described by each three-dimensional brain blood
The tube space location drawing is compound according to its corresponding exploring sequence progress, is specifically included with obtaining three-dimensional cerebrovascular image：
The mobile sequence of ring battle array probe is obtained, and obtains the exploring sequence of each detecting location according to the mobile sequence；
The composite sequence of each three-dimensional cerebrovascular spatial position figure is determined according to the exploring sequence, and will according to the composite sequence
Each three-dimensional vascular space location drawing progress is compound, to generate three-dimensional cerebrovascular image.
9. according to claim 8 through cranium three-dimensional cerebrovascular composite imaging method, which is characterized in that described according to the detection
Sequence determines the composite sequence of each three-dimensional cerebrovascular spatial position figure, and according to the composite sequence by each three-dimensional vascular space position
It is compound to set figure progress, is specifically included with generating three-dimensional cerebrovascular image：
The position of the left and right probe of the ring battle array probe is obtained, and encephalic reference point is determined according to the position of the left and right probe；
It is using the reference point as foundation, each three-dimensional vascular space location drawing is compound according to composite sequence progress, to generate three-dimensional
Blood-vessel image.
10. a kind of through cranium three-dimensional cerebrovascular complex imaging system, which is characterized in that it include ring battle array probe and control device,
The ring battle array probe carries out focusing ultrasonic wave scanning to encephalic by mechanical device control, receives the echo letter of each scan position
Number；The control device for realizing as described in claim 1-9 is any through in cranium three-dimensional cerebrovascular composite imaging method
Step.
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| PCT/CN2018/106031 WO2019214127A1 (en) | 2018-05-07 | 2018-09-17 | Transcranial three-dimensional cerebrovascular compound imaging method and system |
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| CN113040821A (en) * | 2021-03-02 | 2021-06-29 | 深圳市德力凯医疗设备股份有限公司 | Intracranial cerebral blood flow three-dimensional imaging denoising method and device, terminal device and storage medium |
| CN113616242A (en) * | 2021-07-05 | 2021-11-09 | 青岛大学附属医院 | Ultrasonic transcranial Doppler acquisition device and system |
| CN113576624A (en) * | 2021-08-27 | 2021-11-02 | 珠海医凯电子科技有限公司 | Puncture depth detection method based on central puncture probe |
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