CN108837262A - A kind of bronchial catheter with antibacterial functions - Google Patents
A kind of bronchial catheter with antibacterial functions Download PDFInfo
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- CN108837262A CN108837262A CN201810650560.XA CN201810650560A CN108837262A CN 108837262 A CN108837262 A CN 108837262A CN 201810650560 A CN201810650560 A CN 201810650560A CN 108837262 A CN108837262 A CN 108837262A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0402—Special features for tracheal tubes not otherwise provided for
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0434—Cuffs
- A61M16/0443—Special cuff-wall materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0434—Cuffs
- A61M16/0445—Special cuff forms, e.g. undulated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D4/00—Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
- C09D4/06—Organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups C09D159/00 - C09D187/00
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1025—Respiratory system
- A61M2210/1035—Bronchi
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- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
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Abstract
The invention discloses a kind of bronchuses with antibacterial functions to manage, and belongs to the field of medical instrument technology.The present invention coats the hydrogel of antibiotic by increasing on the outside of conventional bronchial tube, has effectively achieved the antibacterial of bronchial catheter；Hydrogel has certain slow releasing function simultaneously, has delayed the release of antibiotic, has extended the time that bronchial catheter is able to use.Further, by the way that helical form protrusion is arranged on the outside of bronchial catheter, the adhesion between hydrogel and bronchial catheter is effectively improved, falling off for hydrogel during use is avoided, ensure that the safety used.The present invention can finally reach not only through a large number of experiments can guarantee outstanding mechanical property, but also can guarantee the effect of preferable anti-microbial property and Durability of antimicrobial effect.
Description
Technical field
The present invention relates to a kind of bronchuses with antibacterial functions to manage, and belongs to the field of medical instrument technology.
Background technique
With the extensive use of medical catheter, the risk that catheter-related Infections: Clinical Study occurs increasingly increases, catheter associated infection
The main reason for hospital infects is had become, length of patient stay's extension, medical expense increase and case fatality rate are often led to
Rising, conduit related blood stream infections be intensive care unit occur nosocomial infection the main reason for.
Medical catheter has become an important factor for concurrent conduit correlation nosocomial infection, especially immune deficiency or glycosuria
Patient, infant, the elderly etc. are easier to that catheter-related Infections: Clinical Study occurs.Bronchial catheter is operating room and intensive care unit
Common conduit, and one of the severely afflicated area that infection occurs, in order to reduce the incidence of infection, the prior art is frequently in conduit
Surface coats the means of antimicrobial coating, achievees the purpose that inhibit bacterial growth.
But existing antimicrobial coating is generally 2 kinds, and one kind is heavy metal ion coating, such as silver ion, heavy metal ion painting
Layer is easy to happen heavy metal ion leakage, there is very big risk；Another kind is antibiotic coating, is asked existing for antibiotic coating
Topic is that antibiotic is easy leakage failure during conduit storage, and in conduit use process, antibiotic is difficult to be released effectively again,
To reach restraining and sterilizing bacteria purpose.
Therefore, it is necessary to develop a kind of new technology, to solve problems of the prior art.
Summary of the invention
To solve the above-mentioned problems, the present invention provides a kind of with the bronchial catheter of antibacterial functions and its preparation side
Method.
Firstly, the present invention provides a kind of bronchial catheter with antibacterial functions, the bronchial catheter includes conduit
Main body and hydrogel layer containing antibiotic；It is the air flue of connection inside the catheter main body, external upper end includes that standard connects
Head, charge valve, inflation instruction ball, external lower end includes inflatable cuff；Pass through inflation between the charge valve and inflatable cuff
Piping connection, inflation instruction ball are located at close charge valve one end of loading line；The hydrogel layer is covered in outside catheter main body
Part between the inflatable cuff and modular connection in portion.
In one embodiment of the invention, the modular connection with other equipment for connecting.
In one embodiment of the invention, the charge valve is check valve.
In one embodiment of the invention, the cladding thickness of hydrogel layer contains inside 1-3mm, the hydrogel layer
There is antibiotic.
In one embodiment of the invention, the outer surface for the catheter main body for having hydrogel layer to cover has shape of threads prominent
It rises, thread segment height is 0.5-1mm, and the bottom edge of adjacent thread protrusion is at a distance of 2-3mm.
In one embodiment of the invention, the bottom edge distance of adjacent thread protrusion is the thread segment height
3 times.
In one embodiment of the invention, shape of threads protrusion cross section is equilateral triangle.
In one embodiment of the invention, it is located at human body when the hydrogel layer is covered in the use of bronchial catheter
Internal part.
In one embodiment of the invention, the hydrogel layer is surface of the uniform fold outside catheter main body.
In one embodiment of the invention, the antibiotic of the hydrogel layer is finely dispersed.
In one embodiment of the invention, the antibiotic is the composition of Multiple Classes of Antibiotics, including：Penicillin
Class, cephalosporins, macrolides, quinolones, aminoglycoside it is one or more.
In the present invention, the thickness of hydrogel refers to that the maximum gauge after the abundant water absorption and swelling of gel, thickness refer to conduit
At a distance from the surface (have threaded bosses refers to screw thread and the bottom edge that catheter surface is connected) to hydrogel exterior layer of main body.
In one embodiment of the invention, the antibiotic includes that mass ratio is respectively
15-20:10-20:5-10:10-20:15-30:The kanamycins, An Benzyl penicillin of 15-30, azlocillin, cephalo
Draw fixed, roxithromycin and Ofloxacin.
In one embodiment of the invention, the antibiotic is mass ratio 15:20:20 Cefradines, roxithromycin
And Ofloxacin.
In one embodiment of the invention, the hydrogel is using N, N- acrylamide and metering system
Sour dimethylaminoethyl is monomer, and N, N- methylene-bisacrylamide is crosslinking agent, is prepared using one-step method.
In addition, the present invention also provides a kind of preparation method of bronchial catheter with antibacterial functions, the preparation side
Method is：
It (1) is respectively (10-20) by mass ratio:(15-30):Cefradine, roxithromycin and the oxygen fluorine sand of (15-30)
Star mixed dissolution forms the antibiotic mixed solution that mass concentration is 30-50mg/L, in 2-8 DEG C in a certain amount of deionized water
Cooling is spare in environment；
(2) example in mass ratio, weighs 6 parts of N, N- acrylamide, and 3 parts of dimethylaminoethyl methacrylates are molten
Solution is placed in magnetic agitation in 30 parts of antibiotic mixed solutions, under 2-8 DEG C of environment stir 15min or more be uniformly mixed, successively plus
Enter 0.4 part of N, N- methylene-bisacrylamide, 0.4 part of potassium peroxydisulfate and 0.1 part of potassium bisulfite, continue to stir 15min with
On；
(3) acquired solution in step (2) is statically placed under 6-8 DEG C of environment after pre-reaction 3-5h, it will be in bronchial catheter body
After part nozzle is closed with leather sheath, internal side conduit is inserted into solution, the reaction was continued under 6-8 DEG C of environment takes out afterwards for 24 hours
Conduit is placed horizontally under 6-8 DEG C of environment by conduit, and conduit is kept to rotate around axis with 10-30 revs/min of speed, makes to lead
Pipe surface liquid the reaction was continued solidification 48h or more；
(4) bronchial catheter obtained by step (3) is placed under infrared lamp and persistently dries 20-60min, vacuum plastic sealing.
In one embodiment of the invention, step (1)-(4) carry out in an aseptic environment.
Beneficial effects of the present invention：
(1) hydrogel has the following advantages that：1. tridimensional network, the physically or chemically key formed between polymer chain makes
Hydrogel is obtained to not readily dissolve；2. good biocompatibility, the hydrogel unfolded completely has certain similar with living tissue physical
Shape, such as softness, high resilience, low biofluid interfacial tension, it is less sensitive to surrounding tissue after being implanted into it, and table
Low interfacial tension between face and body fluid reduces protein absorption and cell adhesion, reduces the possibility being negatively immunoreacted
Property；3. having water-swellable, process, that is, drug release process of swelling, this can enhance the residence time of drug and tissue infiltration
Property；It, can be as the auxiliary of regeneration and drug load 4. the physiochemistry of hydrogel is similar to blastema epimatrix
Help material.
(2) present invention coats the hydrogel of antibiotic by increasing on the outside of conventional bronchial tube, has effectively achieved branch
The antibacterial of tracheal catheter；Hydrogel has certain slow releasing function simultaneously, has delayed the release of antibiotic, has extended bronchus and lead
The time that pipe is able to use.
(3) present invention effectively improves hydrogel and branch gas by the way that helical form protrusion is arranged on the outside of bronchial catheter
Adhesion between pipe conduit avoids and (for example is inserted into bronchus or from people's lung into the lung of people during use
When extracting bronchus) hydrogel falls off, it ensure that the safety used.Meanwhile it is prominent for the height of helical form protrusion, helical form
The spacing distance risen has also carried out a large amount of experiment, on the one hand discovery flight pitch influences the adhesiveness (power of hydrogel and conduit
Learn performance), the amount that on the other hand influences hydrogel to influencing antibiotic property and Durability of antimicrobial effect, finally just find in thread segment
Height is 0.5-1mm, and the bottom edge of adjacent thread protrusion can reach relatively good antibiotic property and mechanical property at a distance of 2-3mm, is protected
The safety and function and effect used is demonstrate,proved.
(4) present invention has found through a large number of experiments, and selection needs the appearance covered with hydrogel layer on catheter main body
Shape of threads protrusion is arranged in face, and wherein shape of threads protrusion cross section is equilateral triangle, and thread segment height is 1mm, adjacent spiral shell
When line protrusion bottom edge is at a distance of 3mm, can finally reach not only can guarantee outstanding mechanical property, but also can guarantee preferable anti-microbial property
With the effect of Durability of antimicrobial effect.
Detailed description of the invention
Fig. 1：Bronchial catheter structural schematic diagram；
Fig. 2：Bronchial catheter splitted along the air flue of catheter main body after schematic cross-section；
Wherein, 1 be catheter main body, 2 be hydrogel layer, 3 be air flue, modular connection 4, charge valve 5, inflation instruction ball 6, fill
Air-casing capsule 7, loading line 8, shape of threads protrusion 9.
Specific embodiment
Anti-microbial property test：Under gnotobasis, 10 are prepared7The physiological saline bacteria suspension of a/mL Diplococcus pneumopniae, by branch gas
It is taken out after being completely immersed in bacteria suspension after the ferrule of pipe conduit both ends, places 6h under room-temperature sterile environment, conduit is immersed and is contained
In the beaker for having 500mL sterile saline, 2min is shaken manually and takes out conduit, 50 μ L liquid is taken to be coated on blood plate culture
Base, constant temperature incubation for 24 hours, counts and grows clump count on culture medium at 37 DEG C.
Durability of antimicrobial effect test：Under gnotobasis, preparing 50mL concentration is 105The physiological saline bacterium of a mL Diplococcus pneumopniae
Conduit to be measured is immersed bacteria suspension, and starts timing by suspension, is taken 1mL liquid every 6h, with 10 times of normal saline dilution, is taken 50 μ
L is coated on blood plate culture medium, and constant temperature incubation for 24 hours, counts and grows clump count on culture medium at 37 DEG C, evaluates Durability of antimicrobial effect.
Mechanics Performance Testing：Conduit to be measured is immersed at least 2h or more in deionized water, inhales its hydrogel part sufficiently
Water, head are fixed on rotor, in one circle black baffle of rotor turnover setting, are started motor, are gradually increased revolving speed, make to lead
Pipe rotates under rotor drive, and pays attention to observing black baffle, when occurring gelatinous mass on plate washer, records motor speed.
Embodiment 1：
A kind of bronchial catheter with antibacterial functions, as shown in Figure 1, the bronchial catheter includes 1 He of catheter main body
Hydrogel layer 2 containing antibiotic；Be the air flue 3 of connection inside the catheter main body, external upper end include modular connection 4,
Charge valve 5, inflation instruction ball 6, external lower end includes inflatable cuff 7；Pass through inflation between the charge valve and inflatable cuff
Pipeline 8 connects, and inflation instruction ball 6 is located at 5 one end of close charge valve of loading line 8；The hydrogel layer is covered in conduit master
Part between inflatable cuff 7 outside body and modular connection 4.
The cladding thickness of hydrogel is 1mm, and finely dispersed antibiotic is contained inside hydrogel layer, is arranged on catheter main body
Shape of threads protrusion 9, shape of threads protrusion cross section are equilateral triangle, and thread segment height is 0.5mm, adjacent thread protrusion bottom edge phase
Away from 2mm.
Embodiment 2：
A kind of bronchial catheter with antibacterial functions, the bronchial catheter include catheter main body and containing antibiotic
Hydrogel layer；It is the air flue of connection inside the catheter main body, external upper end includes modular connection, charge valve, inflation instruction
Ball, external lower end include inflatable cuff；It is connected between the charge valve and inflatable cuff by loading line, inflation instruction ball
Positioned at close charge valve one end of loading line；The hydrogel layer is covered in inflatable cuff outside catheter main body and standard connects
Part between head.
The cladding thickness of hydrogel is 3mm, and finely dispersed antibiotic is contained inside hydrogel layer, is arranged on catheter main body
Shape of threads protrusion, shape of threads protrusion cross section are equilateral triangle, and thread segment height is 1mm, and adjacent thread protrusion bottom edge is apart
3mm。
Embodiment 3：
A kind of bronchial catheter with antibacterial functions, the bronchial catheter include catheter main body and containing antibiotic
Hydrogel layer；It is the air flue of connection inside the catheter main body, external upper end includes modular connection, charge valve, inflation instruction
Ball, external lower end include inflatable cuff；It is connected between the charge valve and inflatable cuff by loading line, inflation instruction ball
Positioned at close charge valve one end of loading line；The hydrogel layer is covered in inflatable cuff outside catheter main body and standard connects
Part between head.
The cladding thickness of hydrogel is 1mm, and finely dispersed antibiotic is contained inside hydrogel layer, is arranged on catheter main body
Shape of threads protrusion, shape of threads protrusion cross section are equilateral triangle, and thread segment height is 1mm, and adjacent thread protrusion bottom edge is apart
3mm。
Embodiment 4：
A kind of preparation method of the bronchial catheter with antibacterial functions, step include：
It (1) is respectively 15 by mass ratio:20:20 Cefradines, roxithromycin and Ofloxacin mixed dissolution are in certain
The deionized water of amount forms the antibiotic mixed solution that mass concentration is 30mg/L, and cooling is spare in 2-8 DEG C of environment；
(2) example in mass ratio, weighs 6 parts of N, N- acrylamide, and 3 parts of dimethylaminoethyl methacrylates are molten
Solution is placed in magnetic agitation in 30 parts of antibiotic mixed solutions, under 2-8 DEG C of environment stir 15min or more be uniformly mixed, successively plus
Enter 0.4 part of N, N- methylene-bisacrylamide, 0.4 part of potassium peroxydisulfate and 0.1 part of potassium bisulfite, continue to stir 15min with
On；
(3) acquired solution in step (2) is statically placed under 6-8 DEG C of environment after pre-reaction 5h, by common branch gas to be processed
After pipe conduit insertion internal body portion nozzle is closed with leather sheath, internal side conduit is inserted into solution, is continued under 6-8 DEG C of environment
Conduit is taken out after reaction 16h, conduit is placed horizontally under 6-8 DEG C of environment, and keep conduit around axis with 10-30 revs/min
Speed rotation makes catheter surface (part between inflatable cuff and modular connection outside catheter main body) liquid the reaction was continued and is solid
Change 48h or more；Obtaining the bronchial catheter that hydrogel with a thickness of 2mm is contained on surface, (wherein, the thickness of hydrogel can pass through
The time that the reaction was continued in control conduit insertion solution controls).
(4) bronchial catheter obtained by step (3) is placed under infrared lamp and persistently dries 60min, vacuum plastic sealing.
Above step carries out in an aseptic environment.
Embodiment 5：
A kind of preparation method of the bronchial catheter with antibacterial functions, step include：
It (1) is respectively 15 by mass ratio:20:20 Cefradines, roxithromycin and Ofloxacin mixed dissolution are in certain
The deionized water of amount forms the antibiotic mixed solution that mass concentration is 30mg/L, and cooling is spare in 2-8 DEG C of environment；
(2) example in mass ratio, weighs 6 parts of N, N- acrylamide, and 3 parts of dimethylaminoethyl methacrylates are molten
Solution is placed in magnetic agitation in 30 parts of antibiotic mixed solutions, under 2-8 DEG C of environment stir 15min or more be uniformly mixed, successively plus
Enter 0.4 part of N, N- methylene-bisacrylamide, 0.4 part of potassium peroxydisulfate and 0.1 part of potassium bisulfite, continue to stir 15min with
On；
(3) acquired solution in step (2) is statically placed under 6-8 DEG C of environment after pre-reaction 5h, by common branch gas to be processed
After insertion internal body portion nozzle is closed with leather sheath when pipe conduit use, internal side conduit is inserted into solution, in 6-8 DEG C of environment
The reaction was continued down takes out conduit afterwards for 24 hours, conduit is placed horizontally under 6-8 DEG C of environment, and keep conduit around axis with 10-30
Rev/min speed rotation, make catheter surface (part between inflatable cuff and modular connection outside catheter main body) liquid after
Continuous reaction solidification 48h or more；Obtain bronchial catheter (wherein, the thickness of hydrogel for the hydrogel that surface is contained with a thickness of 3mm
The time that the reaction was continued in solution can be inserted by control conduit to control).
(4) bronchial catheter obtained by step (3) is placed under infrared lamp and persistently dries 60min, vacuum plastic sealing.
Above step carries out in an aseptic environment.
Embodiment 6：
A kind of preparation method of the bronchial catheter with antibacterial functions, step include：
It (1) is respectively 15 by mass ratio:20:20 Cefradines, roxithromycin and Ofloxacin mixed dissolution are in certain
The deionized water of amount forms the antibiotic mixed solution that mass concentration is 30mg/L, and cooling is spare in 2-8 DEG C of environment；
(2) example in mass ratio, weighs 6 parts of N, N- acrylamide, and 3 parts of dimethylaminoethyl methacrylates are molten
Solution is placed in magnetic agitation in 30 parts of antibiotic mixed solutions, under 2-8 DEG C of environment stir 15min or more be uniformly mixed, successively plus
Enter 0.4 part of N, N- methylene-bisacrylamide, 0.4 part of potassium peroxydisulfate and 0.1 part of potassium bisulfite, continue to stir 15min with
On；
(3) acquired solution in step (2) is statically placed under 6-8 DEG C of environment after pre-reaction 5h, bronchus to be processed is led
(structure has following improvement to pipe on the basis of common bronchial catheter：It needs to be covered with hydrogel layer on catheter main body
Shape of threads protrusion is arranged in outer surface, and wherein shape of threads protrusion cross section is equilateral triangle) after internal body portion nozzle closed with leather sheath,
Internal side conduit is inserted into solution, the reaction was continued under 6-8 DEG C of environment takes out conduit afterwards for 24 hours, and conduit is placed horizontally at
Under 6-8 DEG C of environment, and conduit is kept to rotate around axis with 10-30 revs/min of speed, makes catheter surface (outside catheter main body
Part between inflatable cuff and modular connection) liquid the reaction was continued solidification 48h or more；Surface is obtained to contain with a thickness of 3mm's
(wherein, the thickness of hydrogel can be inserted into the time that the reaction was continued in solution by control conduit to the bronchial catheter of hydrogel
To control).
(4) bronchial catheter obtained by step (3) is placed under infrared lamp and persistently dries 60min, vacuum plastic sealing.
Above step carries out in an aseptic environment.
Wherein, the screw thread of bronchial catheter to be processed used in step (2), is respectively provided with following features：
Experimental group A：Thread segment height is 1mm, and adjacent thread protrusion bottom edge is at a distance of 3mm；
Experimental group B：Thread segment height is 1mm, and adjacent thread protrusion bottom edge is at a distance of 2mm；
Experimental group C：Thread segment height is 1mm, and adjacent thread protrusion bottom edge is at a distance of 4mm；
Experimental group D：Thread segment height is 1.5mm, and adjacent thread protrusion bottom edge is at a distance of 3mm；
Experimental group E：Thread segment height is 0.5mm, and adjacent thread protrusion bottom edge is at a distance of 3mm.
To anti-microbial property, Durability of antimicrobial effect, the mechanical property of the obtained bronchial catheter with antibacterial functions of embodiment 4-6
It can be carried out test.The results are shown in Table 1.
Table 1 has the bronchial catheter performance test of antibacterial functions
Note：Blank 1 refers to the common bronchial catheter of not hydrogel；Blank 2 refers to the method similar using embodiment 5
The bronchial catheter (non-threaded) of the hydrogel thickness 3mm for not adding antibiotic preparation of preparation.
Bacteriostasis rate=(the bacterium colony number of blank 1-test sample bacterium colony number)/blank 1 bacterium colony number * 100%
Although the present invention has been described by way of example and in terms of the preferred embodiments, it is not intended to limit the invention, any to be familiar with this skill
The people of art can do various change and modification, therefore protection model of the invention without departing from the spirit and scope of the present invention
Enclosing subject to the definition of the claims.
Claims (6)
1. a kind of bronchial catheter with antibacterial functions, which is characterized in that the bronchial catheter includes catheter main body and contains
There is the hydrogel layer of antibiotic；It is the air flue of connection inside the catheter main body, external upper end includes modular connection, inflation
Valve, inflation instruction ball, external lower end includes inflatable cuff；Connected between the charge valve and inflatable cuff by loading line
It connects, inflation instruction ball is located at close charge valve one end of loading line；The hydrogel layer is covered in filling outside catheter main body
Part between air-casing capsule and modular connection；The thickness of hydrogel layer is in 1-3mm；Catheter main body outer surface is to have shape of threads prominent
It rises；The thread segment height of the shape of threads protrusion is 0.5-1mm, and the bottom edge of adjacent thread protrusion is at a distance of 2-3mm.
2. the bronchial catheter according to claim 1 with antibacterial functions, which is characterized in that the shape of threads protrusion
Cross section is equilateral triangle.
3. the bronchial catheter according to claim 1 with antibacterial functions, which is characterized in that the hydrogel layer covering
Positioned at the part of inside of human body when the use of bronchial catheter.
4. the bronchial catheter according to claim 1 with antibacterial functions, which is characterized in that the antibiotic is a variety of
The composition of antibiotic, including：One kind of penicillins, cephalosporins, macrolides, quinolones, aminoglycoside
Or it is a variety of.
5. the bronchial catheter according to claim 1 with antibacterial functions, which is characterized in that the hydrogel is to use
N, N- acrylamide and dimethylaminoethyl methacrylate are monomer, and N, N- methylene-bisacrylamide is crosslinking
Agent is prepared using one-step method.
6. a kind of preparation method of the bronchial catheter with antibacterial functions, the preparation method is that：
It (1) is respectively 10-20 by mass ratio:15-30:Cefradine, roxithromycin and the Ofloxacin mixed dissolution of 15-30
In a certain amount of deionized water, the antibiotic mixed solution that mass concentration is 30-50mg/L is formed, it is cooling in 2-8 DEG C of environment
It is spare；
(2) example in mass ratio, weighs 6 parts of N, N- acrylamide, 3 parts of dimethylaminoethyl methacrylates are dissolved in
30 parts of antibiotic mixed solutions, are placed in magnetic agitation, and 15min or more is stirred under 2-8 DEG C of environment and is uniformly mixed, is sequentially added
0.4 part of N, N- methylene-bisacrylamide, 0.4 part of potassium peroxydisulfate and 0.1 part of potassium bisulfite continue to stir 15min or more；
(3) acquired solution in step (2) is statically placed under 6-8 DEG C of environment after pre-reaction 3-5h, by bronchial catheter internal body portion
After nozzle is closed with leather sheath, internal side conduit is inserted into solution, the reaction was continued under 6-8 DEG C of environment takes out conduit afterwards for 24 hours,
Conduit is placed horizontally under 6-8 DEG C of environment, and conduit is kept to rotate around axis with 10-30 revs/min of speed, makes catheter surface
Liquid the reaction was continued solidification 48h or more；
(4) bronchial catheter obtained by step (3) is placed under infrared lamp and persistently dries 20-60min, vacuum plastic sealing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810650560.XA CN108837262A (en) | 2018-06-22 | 2018-06-22 | A kind of bronchial catheter with antibacterial functions |
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| CN201810650560.XA CN108837262A (en) | 2018-06-22 | 2018-06-22 | A kind of bronchial catheter with antibacterial functions |
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| CN108837262A true CN108837262A (en) | 2018-11-20 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1261288A (en) * | 1997-06-23 | 2000-07-26 | 斯蒂斯生物聚合物公司 | Aderent, flexible hydrogel and medicated coatings |
| CN1960736A (en) * | 2004-02-27 | 2007-05-09 | 海德罗默公司 | Anti-infectious hydrogel compositions |
| CN101653635A (en) * | 2009-09-03 | 2010-02-24 | 中国人民解放军第二军医大学 | Manual tracheotomy tube with antibacterial nano material coating |
| CN106589225A (en) * | 2015-10-20 | 2017-04-26 | 中国石油化工股份有限公司 | Polymer gel particle for profile control and water plugging of deep parts as well as preparation method thereof |
| US20180015248A1 (en) * | 2016-07-13 | 2018-01-18 | NeuVT Limited | High flexibility, kink resistant catheter shaft |
| CN107837428A (en) * | 2017-10-31 | 2018-03-27 | 无锡中科光远生物材料有限公司 | A kind of fungistatic coating material for being sustained antibiotic |
-
2018
- 2018-06-22 CN CN201810650560.XA patent/CN108837262A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1261288A (en) * | 1997-06-23 | 2000-07-26 | 斯蒂斯生物聚合物公司 | Aderent, flexible hydrogel and medicated coatings |
| CN1960736A (en) * | 2004-02-27 | 2007-05-09 | 海德罗默公司 | Anti-infectious hydrogel compositions |
| CN101653635A (en) * | 2009-09-03 | 2010-02-24 | 中国人民解放军第二军医大学 | Manual tracheotomy tube with antibacterial nano material coating |
| CN106589225A (en) * | 2015-10-20 | 2017-04-26 | 中国石油化工股份有限公司 | Polymer gel particle for profile control and water plugging of deep parts as well as preparation method thereof |
| US20180015248A1 (en) * | 2016-07-13 | 2018-01-18 | NeuVT Limited | High flexibility, kink resistant catheter shaft |
| CN107837428A (en) * | 2017-10-31 | 2018-03-27 | 无锡中科光远生物材料有限公司 | A kind of fungistatic coating material for being sustained antibiotic |
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Application publication date: 20181120 |