CN108814781A - Biodegradable stent and preparation method thereof - Google Patents
Biodegradable stent and preparation method thereof Download PDFInfo
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- CN108814781A CN108814781A CN201810680424.5A CN201810680424A CN108814781A CN 108814781 A CN108814781 A CN 108814781A CN 201810680424 A CN201810680424 A CN 201810680424A CN 108814781 A CN108814781 A CN 108814781A
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Abstract
The present invention relates to biodegradable stent and preparation method thereof, the method includes：Original tube preparation step, wherein there is the original tube for making a reservation for inside and outside diameter by degradation material preparation；With bracket preparation step, original tube is wherein prepared into biodegradable stent by cutting, the bracket includes wave ring and the connecting rod for connecting adjacent wave ring, wherein the wave ring cutting is cut into wavy wave bar, and the quantity of the wave crest of the wave ring in a circumferential direction is 4~12.Wherein, the bracket has the wall thickness less than or equal to 150 μm, and the angle between wave bar is set greater than equal to 80 °.Biodegradable stent of the invention has the following advantages that：Support force is high at once for it, is not broken；And in the case where bracket entirety wall thickness is less than or equal to 150 μm, the mechanical property of bracket does not occur significantly to decline；The wave bar of bracket is thin, and profile is small, can pass through at stenotic lesion；In addition, endothelialization speed is fast using bracket of the invention, inflammatory reaction will not be caused.
Description
The application be on 2 16th, 2015 the applying date, application No. is 201510086417.9, entitled " can drop
The divisional application of the application for a patent for invention of solution bracket and preparation method thereof ".
Technical field
The biodegradable stent and preparation method thereof that the present invention relates to a kind of for medical application.
Background technique
Important instrument of the bracket as treatment hemadostewnosis, has obtained more and more wide answer in cardiovascular disease field
With.Be now widely used for clinic is metallic support.Since metallic support will permanently retain in body after completing treatment task
It is interior, exist and weakens MRI coronarius or CT images, interference surgery revascularization, the formation for hindering offshoot circulation, inhibits blood vessel
The defects of positivity is remolded.
In view of these problems existing for metallic support, Biodegradable scaffold draws as a kind of possible substitution solution
The extensive concern of people is played.Biodegradable scaffold is made of degradable polymer material or metal material, in implantation disease
Displacement postpones can play the role of support blood vessels in a short time, realize revascularization.After treatment is completed, biodegradable
The organic matter that bracket can be degraded into human body environment can be absorbed by the body, be metabolized, the final bracket can disappear.
It is current research hotspot by the biodegradable stent of raw material of biodegradable polymer material.It has taken at present
CE certification the BVS bracket of Abbott Laboratories and the Desolve bracket of Elixir be exactly this field representative, they safe and effective
Property also has already been through clinical verification.But common biodegradable polymer material, such as it is polylactic acid, polyglycolic acid, poly-
Caprolactone etc., mechanical property is weaker, and Young's modulus only has 0.1-4GPa or so, and intensity only has 40-80MPa.Due to material
Mechanical strength it is low, after bracket is made by these materials, the radial support power of bracket is smaller, is difficult to play support blood vessels
Effect.Therefore common Biodegradable scaffold realizes the purpose for improving its intensity often through the wall thickness for increasing bracket.Mesh
Preceding degradable polymer bracket wall thickness in the market is all thicker, for example, the Desolve branch of the BVS bracket of Abbott Laboratories and Elixir
Frame wall thickness is at 150 μm or more, metallic support (70-120 μm of wall thickness range) significantly larger than currently on the market.
But increasing wall thickness can be such that the profile of bracket increases, so that bracket is deteriorated for the passability of lesion vessels, meeting simultaneously
The lumen Loss Rate of blood vessel after raising stenter to implant.If bracket wall thickness is too thick, some Long lesions need overlapping in clinic
(overlap) when being implanted into two brackets, the bracket wall thickness that will lead to overlapping place is thicker, to seriously affect blood flow percent of pass.Separately
Outside, increase the growth that bracket wall thickness is also unfavorable for endothelial cell after implantation, be also easy to cause inflammation, forming thrombus leads to blood vessel again
It is narrow etc..These problems become the biodegradable stent listed and occur the main reason for adverse events in clinic.Reduce bracket
Wall thickness can efficiently solve the problems in above-mentioned clinical process.Therefore, the wall thickness for reducing biodegradable stent has become at present
Industry development trend, have more and more producers start carry out thin-walled bracket research.
But as described above, according to the prior art, merely reduce bracket wall thickness will lead to bracket mechanical support it is insufficient,
It cannot achieve effective support to lesion vessels.
A kind of method for manufacturing bracket is proposed in 102497970 A of patent CN, wherein it is radially expanded PLLA tubing,
Being radially expanded percentage is 300% to 500%.It is proposed that high expansion ratio can improve the crystallinity of polymer in the patent, if
Crystallinity is too high, and polymer will become frangible easily rupturable, and toughness reduces, therefore the expansion ratio recommended in the patent is 300%
~500%.The bracket prepared by method described in the patent, it is difficult to while obtaining relatively thin wall thickness and higher mechanical property
Energy.
In order to efficiently solve the above problem, need to reduce the wall thickness of bracket while keeping support intensity.The present invention
Purpose be to be to provide for a kind of novel biodegradable stent, have the characteristics that wall is thin, intensity is high.Meanwhile the present invention provides
Method for manufacturing the biodegradable stent.
Summary of the invention
The present inventor it has been investigated that, can be designed by special supporting structure, reduce biodegradable stent
While wall thickness, the mechanical property of bracket is kept to meet clinical requirement.In addition, can also join by adjusting suitable expansion process
Number, even if in the case where being radially expanded than being greater than 500%, the size of crystallite dimension still can be efficiently controlled in tubing,
Ensure that material is still able to maintain enough toughness under high-crystallinity, and significantly improve the intensity of material, so as to
While reducing bracket wall thickness, the mechanical property of bracket is kept to meet clinical requirement.
According to an aspect of the present invention, a kind of method for manufacturing biodegradable stent is provided, the method includes：
Original tube preparation step, wherein preparing original tube using degradation material, the original tube has predetermined
Inside and outside diameter；With
Bracket preparation step, wherein original tube is prepared into biodegradable stent, the biodegradable stent tool by cutting
There is wave ring and connect the connecting rod of adjacent wave ring, wherein being cut into the wave ring cutting with wavy wave bar, and the wave
The quantity of the wave crest of ring in a circumferential direction is 4~12, and the biodegradable stent has the wall thickness less than or equal to 150 μm, and
And the angle between the wave bar is set greater than equal to 80 °.
Preferably, the angle between the wave bar is set greater than equal to 95 °.
Preferably, the wave number of rings amount on the axial direction of the bracket in 1mm unit length is set greater than equal to 1
Group.
Preferably, the wall thickness of the bracket is 70 μm~150 μm.
Preferably, the method also includes executing expansion step to original tube before the bracket preparation step,
In the expansion step, original tube is put into mold, with the swollen of 60 DEG C~120 DEG C of expansion temperature and 200psi~500psi
Swelling pressure power carries out heating pressurization to original tube, so that original tube is expanded to the internal diameter that its outer diameter reaches mold, and after expansion
Tubing and the internal diameter of original tube ratio are greater than 500%.
In the case where the preparation process of bracket includes the expansion step, it is preferable that in the expansion step, also exist
Original tube be radially expanded before, expansion when and/or expansion after tubing is axially stretched.
Preferably, the link position of the connecting rod connection adjacent wave ring is at least one of the following：By wave crest to wave
Paddy, by wave crest to wave crest, or by trough to trough.
Preferably, the degradation material is degradable polymer.Preferably, the degradable polymer is birdsed of the same feather flock together for polyester
Close object, the copolymer of polyester polymer or the blend of polyester polymer.Preferably, the degradable polymer is selected from：
Polylactic acid；Polyglycolic acid；Polycaprolactone；Or polydioxanone.
According to another aspect of the present invention, a kind of biodegradable stent is provided, and preparing according to the method for the present invention
At.
A kind of novel degradable support the present invention provides wall thickness lower than biodegradable stent currently on the market, integral wall
Thickness is less than or equal to 150 μm, and mechanical property is not less than existing biodegradable stent in the market.The thin biodegradable stent of this wall
It can solve the problems such as current biodegradable stent passability is poor, endothelialization is slow, lumen Loss Rate is high.
The biodegradable stent that the present invention obtains has the following advantages that：Support force is high at once for it, is not broken；And it is propping up
In the case that frame entirety wall thickness is less than or equal to 150 μm, the mechanical property of bracket does not occur significantly to decline, existing not less than in the market
Some biodegradable stents；The wave bar of bracket is thin, and profile is small, can pass through at stenotic lesion；In addition, using branch of the invention
In the case where frame, endothelialization speed is fast, will not cause inflammatory reaction.
Detailed description of the invention
Fig. 1 shows the original tube for manufacturing bracket.
Fig. 2 is the schematic diagram of original tube inflation.
Fig. 3 shows the deployed configuration of biodegradable stent of the invention.
Specific embodiment
In the following, being carried out to biodegradable stent according to the preferred embodiment of the invention and its manufacturing method detailed in conjunction with attached drawing
Description.
Bracket of the invention is for example prepared by biodegradable polymer, but can also be used other it is any it is suitable can
Degradable material.The degradable polymer that can be used includes but is not limited to：Polylactic acid；Polyglycolic acid；Polycaprolactone；Poly- dioxy six
The polyester polymers such as cyclic ketones；Or the copolymer or blend etc. of these polymer materials.
The manufacturing process of bracket of the invention is described below.Specifically, biodegradable stent of the invention passes through following step
It is rapid to manufacture：
First：Original tube preparation step, wherein preparing original tube 20 by degradation material.It shows and is used in Fig. 1
Prepare the original tube 20 of bracket.As shown in Figure 1, the original tube 20 is usually hollow cylindrical, there is scheduled outer diameter
With scheduled internal diameter.The method for being used to prepare original tube, such as extrusion molding or weave, are known to those skilled in the art
, details are not described herein.
Original tube 20 can have not to be needed in this case with identical diameter and wall thickness needed for final bracket
By expansion step described below, can be directly used for preparing bracket.According to the present invention, the wall of original tube 20 in this case
Thickness is less than or equal to 150 μm.
Alternatively, original tube 20 can have lesser inside and outside diameter and biggish wall thickness compared with final bracket.At this
Kind in the case of, first to original tube 20 carry out expansion process, outer diameter needed for reaching final bracket, internal diameter and/or wall thickness,
To realize the effect of thin-walled, bracket is then prepared again.The outer diameter and inner diameter of original tube 20 is generally according in expansion step below
The expansion ratio mentioned controls.Specifically, outer diameter, the internal diameter of the scheduled internal diameter of original tube and outer diameter by inflated tube material
And/or wall thickness outer diameter, internal diameter and/or the wall thickness of bracket (i.e. required for) and expansion ratio (i.e. inflated tube material and original pipe
The internal diameter ratio of material) it codetermines.That is,
The internal diameter of original tube=(wall thickness of the outer diameter -2* inflated tube material of inflated tube material)/expansion ratio
The wall thickness of outer diameter=original tube internal diameter+2* original tube of original tube.
Above-mentioned calculation formula is known in those skilled in the art.In actual operation, according to outer after required expansion
Diameter, internal diameter and/or wall thickness and expansion ratio can calculate outer diameter, the internal diameter of original tube according to the principle that total volume is constant
And/or wall thickness.In general, the external diametrical extent of original tube 20 can be 1.0mm~3.0mm, inside diameter ranges can be 0.2mm~1mm.
Second (optional step)：Expansion step.There is smaller outer diameter and larger compared with final bracket in original tube 20
In the case where wall thickness, original tube 20 is put into suitable mold 10 (as shown in fig. 1), original tube 20 is heated
Pressurization, makes original tube 20 be expanded to its outer diameter and reaches the internal diameter of mold 10, to obtain outer diameter needed for having final bracket, interior
The shaping pipe of diameter and/or wall thickness, to realize the effect of thin-walled.Fig. 2 be make in a mold original tube 20 expansion obtain it is swollen
The schematic diagram of tubing 30 after swollen, the arrow in Fig. 2 respectively indicate tubing in the radial and axial power being subject to.
Used mold is it is known to the person skilled in the art that details are not described herein.In expansion step,
Heating method is unlimited, and the Resistant heating being wrapped on mold 10 can be used, and can also pass through hot gas or irradiated heat.Institute
Glass transition temperature of the temperature being heated to usually above used polymer material and the melting lower than the polymer material
Temperature.Pressuring method can for example be realized in the following way：By the closed at one end of original tube 20, the other end and high-pressure gas circuit
(not shown) is connected；High pressure gas, such as nitrogen are filled with into original tube 20, to make its expansion.It is this to pass through high pressure gas
The mode that body expands original tube 20 can be described as inflation.
In addition, heat pressurization while, can before original tube 20 is radially expanded, expansion simultaneously and/or expansion after
Tubing 20 is axially stretched, to further decrease the wall thickness of inflated tube material, realizes thin-wall pipes.Stretch range can basis
The wall thickness of required realization is adjusted.
According to the present invention, in expansion step, the internal diameter ratio of inflated tube material (also referred to as shaping pipe) and original tube
(that is, expansion ratio) is greater than 500%, and the wall thickness of inflated tube material is decreased below equal to 150 μm.The present inventor's hair
It is existing, by using suitable expansion temperature and the bulbs of pressure, enable to control the ruler of crystal grain while improving expansion rate
The very little toughness to guarantee material.Specifically, in the present invention, the expansion temperature that tubing is arranged is 60 DEG C~120 DEG C, turgor pressure
Power is 200psi~500psi, and expansion ratio is greater than 500%.Pass through above-mentioned means, it is ensured that prepared bracket is small in wall thickness
While being equal to 150 μm, the intensity of bracket is not influenced.But it should be recognized that expansion step is for the present invention not
It is required.According to the present invention, it even without expansion step, can also be designed by special supporting structure, can be dropped reducing
While solving bracket wall thickness, guarantee that the mechanical property of bracket meets clinical requirement.
In expansion step, the size of expansion ratio and amount of tension can be adjusted according to the wall thickness of required shaping pipe.
After completing expansion, keep tubing cooling.Cooling means can be used well known by persons skilled in the art any suitable
Cooling means, details are not described herein.
Third：Bracket preparation step.For example, by patterning method, by with outer diameter needed for bracket and wall thickness original tube or
Shaping pipe after expansion is prepared into the biodegradable stent of required structure.For example, can be cut by laser by original tube or at
Type tubing is cut into biodegradable stent 100 shown in Fig. 3.It is woven into after original tube or shaping pipe can also being cut into small item
The bracket of required structure.
Fig. 3 shows the deployed configuration of biodegradable stent 100 of the invention.In the figure, left and right directions represents axial direction,
Up and down direction represents circumferencial direction.As shown in figure 3, bracket 100 of the invention includes multiple wave rings, each wave ring is cut into tool
There is wavy wave bar 101.Wave bar 101 can be compressed and expand.Multiple 101 parallel arrangeds of wave bar, adjacent wave bar 101 (or
Person says wave ring) between connected by connecting rod 102.
Fig. 3 illustrates only a kind of illustrative supporting structure.It should be understood that supporting structure of the invention is not limited to Fig. 3
Shown in form, and can there are many variation.For example, can be substantially aligned in Wave crest and wave trough as shown in Figure 3 between wave bar 101
State, Wave crest and wave trough can also be staggered each other.Connecting rod 102 can use straight profiled bat (as shown in Figure 3) and/or N-type bar.Wave
The thickness of bar 101 and connecting rod 102 may be the same or different.Preferably, the thickness of wave bar 101 and connecting rod 102 is not
It is identical.
The link position that connecting rod 102 connects wave bar 101 can be by wave crest to trough, or by wave crest to wave crest, or by
Trough is at least one of to trough etc..Preferably, wave bar 101 in a circumferential direction wave crest quantity can be 4~12.This hair
The whole wall thickness of bright bracket 100 is less than or equal to 150 μm.Particularly, wall thickness is in the range of 70 μm~150 μm or 70 μm
~120 μm or 70 μm~100 μm.
As described above, in the stent fabrication process for including expansion process, it can be by the way that suitable expansion parameters be arranged, such as
Expansion temperature and the bulbs of pressure prepare the high bracket of thin-walled, intensity using biggish expansion ratio.In addition to this, as additional
Or substitution, it can also be designed by improving the structure of bracket, to improve the intensity of prepared bracket, to prepare thin-walled, strong
Spend high bracket.Especially for the stent fabrication process without expansion process, made by the structure design of bracket itself
The high bracket of standby thin-walled, intensity is particularly important.Specifically, the structure design for improving bracket includes the angle improved between wave bar
The combination of the axial density or the two of degree, increase wave bar.
On the one hand, in bracket of the invention, can by improve wave bar between angle come guarantee bracket wall thickness be less than etc.
While 150 μm, improve the intensity of bracket.Here, the angle between wave bar refers to two parts of the wave bar at wave crest or trough
Between be formed by angle (as shown in α in Fig. 3).Preferably, in bracket of the invention, angle between wave bar be more than or equal to
80 ° and less than 180 °.It is further preferred that the angle between wave bar is more than or equal to 95 ° and less than 180 °.
It on the other hand, can be small in bracket wall thickness to guarantee by increasing the axial density of wave bar in bracket of the invention
While being equal to 150 μm, improve the intensity of bracket.Preferably, in bracket of the invention, 1mm unit in the axial direction
Wave bar quantity in length is more than or equal to 1 group (that is, 1 circle).It is further preferred that the wave in 1mm unit length in the axial direction
Bar quantity is more than or equal to 1.5 groups or 2 groups.
It should be understood that using the setting of either side in the axial density of angle and wave bar between wave bar described above, all
It can play the role of improving support intensity.The angle between improving wave bar is taken at the same time and increases this two side of the axial density of wave bar
In the case where the measure of face, the requirement to either side can relative reduction.For example, taking above-mentioned two aspects measure simultaneously, that is, setting
Angle between wave bar is that the wave bar quantity in 1mm unit length is more than or equal to 1 group more than or equal to 80 °, and in the axial direction,
It is fully able to guarantee in this way while bracket wall thickness is less than or equal to 150 μm, significantly improves the intensity of bracket.If only with upper
A kind of measure is stated, then corresponding parameter setting can be obtained some higher, can more efficiently improve support intensity in this way, thus
It is more favorable.For example, can preferred scheme as described above, the angle between wave bar is set as being more than or equal to 95 °, or
Wave bar quantity on axial direction in 1mm unit length is set as to be more than or equal to 1.5 groups or 2 groups.
Bracket can be further improved by combining above-mentioned improved structure to design for the bracket Jing Guo expansion process
Intensity.
Biodegradable stent of the invention has the advantages that wall is thin, intensity is high, has significance in terms of clinical application.Its
Biodegradable stent wall thickness more currently on the market is thinner, and bracket entirety wall thickness is less than or equal to 150 μm.Particularly, wall thickness is 70 μm
~150 μm.Wave bar is thin, and it is small that bracket pressure holds rear profile, has superior passage capacity, bracket is enabled to pass through narrow disease
At change.It has the characteristics that intensity is high simultaneously, is able to maintain enough mechanical supports, meets the support requirement of lesion vessels.And
And using bracket of the invention, endothelial cell growth is rapid, will not cause inflammatory reaction completely.
In addition, the bracket being prepared into according to the method for the present invention at once and room temperature store 6 months bracket radially prop up
Support force can achieve 120KPa or more, and the relaxation shrinkage after stent-expansion can control within 5%, and support force and retraction reach
Metallic support is horizontal.Bracket is not easy to be broken in process of expansion.Bracket profile is small, the passability of bracket in the blood vessel
It is good.
Two examples of preparation method of the invention are described below.
Embodiment one：
The polymer material for the original tube chosen in the present embodiment is Biodegradable polymer material polylactic acid.It will gather
Lactic acid particle obtains the original tube that outer diameter is 1.3mm, internal diameter is 0.5mm by squeezing out.The original tube, which is put into internal diameter, is
In the stainless steel tubular die of 3.2mm, as shown in Figure 1.By the closed at one end of polylactic acid original tube, the other end and high-pressure gas circuit
It is connected.Firstly, being heated to 100 DEG C of temperature to original tube and tubular die, pressure is then filled with into original tube is
The high pressure nitrogen of 400psi, while original tube is axially stretched, stretching distance 40mm.Original tube is in high temperature, height
Pressure and outer diameter 3.2mm is prepared under conditions of stretching, internal diameter 3.0mm, the tubing of wall thickness 0.1mm, as shown in Figure 2.Tubing is whole
The expansion rate of body is 600%.Whole system is quickly cooled to room temperature later, then pressure release, the tubing after taking out inflation.It is logical
Laser cutting is crossed, bracket as shown in Figure 3 is finally obtained.
The bracket pressure that preparation is completed is held on suitable sacculus, the outer diameter that pressure holds after-poppet is 1.27mm.Then 37
DEG C physiological saline in stent-expansion to outer diameter 3.2mm, bracket is not broken in process of expansion.After sacculus is withdrawn, measurement
The support force for expanding after-poppet is 185kpa or so.
The comparison of the BVS bracket of the test specific value and metallic support and Abbott of the bracket that the present embodiment obtains is such as
Shown in table 1.
The comparison of table 1 the present embodiment bracket and prior art bracket
Meanwhile holding the bracket pressure that same method is prepared on suitable sacculus, it is then vacuumized, is filled with aluminium foil bag
Nitrogen, and sealed package are placed 6 months at room temperature.Then bracket is taken out, bracket in 37 DEG C of physiological saline
It is expanded to outer diameter 3.2mm, bracket is not broken in process of expansion.After sacculus is withdrawn, the support force of measurement expansion after-poppet, knot
Fruit is 140kpa.
Embodiment two：
The polymer material for the original tube chosen in the present embodiment is that Biodegradable polymer material PLLA, PDLA are total
Mixed object (PDLLA), blending ratio 50:50.The blending particle is obtained into outer diameter by squeezing out as 3.2mm, internal diameter 3.06mm
Original tube.Original tube after extrusion is cut into bracket.The number of used supporting structure wave crest in a circumferential direction
Amount is 9, and angle is 150 ° between wave bar, and connecting rod is connected to trough by wave crest, the wave bar quantity about 2 in unit length (1mm)
Group.The bracket obtained after cutting intensity with higher.
The bracket pressure that preparation is completed is held on suitable sacculus, the outer diameter that pressure holds after-poppet is 1.22mm.Then 37
DEG C physiological saline in stent-expansion to outer diameter 3.2mm, bracket is not broken in process of expansion.Measurement expansion after-poppet
Support force, result are 140kpa or so.
Meanwhile holding the bracket pressure that same method is prepared on suitable sacculus, it is then vacuumized, is filled with aluminium foil bag
Nitrogen, and sealed package are placed 6 months at room temperature.Then bracket is taken out, bracket in 37 DEG C of physiological saline
It is expanded to outer diameter 3.2mm, bracket is not broken in process of expansion.After sacculus is withdrawn, the support force of measurement expansion after-poppet, knot
Fruit is 125kpa or so.
Above in conjunction with the embodiment of the present invention and attached drawing, technical solution of the present invention is described in detail, so that this
Field technical staff more fully understands technical solution of the present invention.It should be understood that described embodiment is only of the invention one
Section Example, instead of all the embodiments.Based on specific embodiment described herein, those of ordinary skill in the art can
With various modifications and changes may be made, these are all fallen within conception range of the invention.
Claims (8)
1. a kind of method for manufacturing biodegradable stent, which is characterized in that the method includes：
Original tube preparation step has the original tube for making a reservation for inside and outside diameter using degradation material preparation；With
Original tube is prepared into dropping for the connecting rod with wave ring and connection adjacent wave ring by cutting by bracket preparation step
Bracket is solved, wherein being cut into the wave ring cutting with wavy wave bar, and the number of the wave crest of the wave ring in a circumferential direction
Amount is 4~12,
Wherein, the wall thickness of the biodegradable stent is 70 μm~150 μm, and the angle between the wave bar is set greater than and is equal to
95°；Wave number of rings amount on the axial direction of the bracket in 1mm unit length is set greater than equal to 1 group.
2. the method as described in claim 1, which is characterized in that the method also includes right before the bracket preparation step
Original tube executes expansion step and original tube is put into mold in the expansion step, with 60 DEG C~120 DEG C of expansion
Temperature and the bulbs of pressure of 200psi~500psi carry out heating pressurization to original tube, so that original tube is expanded to its outer diameter and reach
To the internal diameter of mold, and inflated tube material and the internal diameter of original tube ratio are greater than 500%.
3. method according to claim 2, which is characterized in that in the expansion step, be also radially expanded in original tube
Before, expansion when and/or expansion after tubing is axially stretched.
4. the method as described in claim 1, which is characterized in that the connecting rod connect the position on the adjacent wave ring be with
It is at least one of lower：By wave crest to trough, by wave crest to wave crest, or by trough to trough.
5. the method as described in claim 1, which is characterized in that the degradation material is degradable polymer.
6. method as claimed in claim 5, which is characterized in that the degradable polymer is polyester polymer, polyesters
The copolymer of polymer or the blend of polyester polymer.
7. method as claimed in claim 6, which is characterized in that the degradable polymer is selected from：Polylactic acid；Polyglycolic acid；
Polycaprolactone；Or polydioxanone.
8. a kind of biodegradable stent, which is characterized in that be prepared by method of any of claims 1-7.
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| CN201810680424.5A CN108814781A (en) | 2015-02-16 | 2015-02-16 | Biodegradable stent and preparation method thereof |
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| CN201810680424.5A CN108814781A (en) | 2015-02-16 | 2015-02-16 | Biodegradable stent and preparation method thereof |
| CN201510086417.9A CN104586548A (en) | 2015-02-16 | 2015-02-16 | Degradable stent and preparation method thereof |
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| CN104983484B (en) * | 2015-05-26 | 2018-07-24 | 无锡市第二人民医院 | It is a kind of to be implanted into high resiliency support arm degradable biological valve system and preparation and application through conduit |
| CN104921855A (en) * | 2015-06-12 | 2015-09-23 | 上海君联医疗设备有限公司 | Absorbable biliary duct stent and preparation method thereof |
| CN105902331A (en) * | 2016-04-08 | 2016-08-31 | 南京永明医疗器械有限公司 | Intravascular stent and preparation method thereof |
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2015
- 2015-02-16 CN CN201810680424.5A patent/CN108814781A/en active Pending
- 2015-02-16 CN CN201510086417.9A patent/CN104586548A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080275537A1 (en) * | 2007-05-04 | 2008-11-06 | Limon Timothy A | Stents with High Radial Strength and Methods of Manufacturing Same |
| CN101543437A (en) * | 2009-04-29 | 2009-09-30 | 乐普（北京）医疗器械股份有限公司 | Method for preparing intravascular stent |
| CN102665781A (en) * | 2010-02-02 | 2012-09-12 | 泰尔茂株式会社 | Bioabsorbable stent |
| CN102429749A (en) * | 2011-07-27 | 2012-05-02 | 微创医疗器械(上海)有限公司 | Processing method of novel biodegradable stent |
| CN102371670A (en) * | 2011-10-14 | 2012-03-14 | 微创医疗器械(上海)有限公司 | New processing method of biodegradable stent |
| CN102440856A (en) * | 2011-12-09 | 2012-05-09 | 微创医疗器械(上海)有限公司 | Biodegradable stent visible under X-ray and preparation method thereof |
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