CN108770948A - It is a kind of using maltodextrin and cyclodextrin as the tributyrin microcapsules of wall material - Google Patents
It is a kind of using maltodextrin and cyclodextrin as the tributyrin microcapsules of wall material Download PDFInfo
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- CN108770948A CN108770948A CN201810430318.1A CN201810430318A CN108770948A CN 108770948 A CN108770948 A CN 108770948A CN 201810430318 A CN201810430318 A CN 201810430318A CN 108770948 A CN108770948 A CN 108770948A
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- Prior art keywords
- tributyrin
- maltodextrin
- cyclodextrin
- microcapsules
- water
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/02—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by the production or working-up
- A23D7/04—Working-up
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
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- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of using maltodextrin and cyclodextrin as the tributyrin microcapsules of wall material, belongs to grease microcapsule technical field.Preparation process is as follows：Maltodextrin and cyclodextrin are added in distilled water, are uniformly mixed in 50~80 DEG C of heating water baths, tributyrin and emulsifier is then added, stirs；The mixture of gained is sheared, homogeneous, spray drying, obtain tributyrin microscapsule powder product.This method preparation process is simple, it is easy to operate, tributyrin microscapsule powder obtained has peculiar smell light, stability and the good characteristic of dissolubility, hence it is evident that improve tributyrin there are peculiar smell, be insoluble in water, poor fluidity the defects of, expand the application of tributyrin.
Description
Technical field
The present invention relates to a kind of using maltodextrin and cyclodextrin as the tributyrin microcapsules of wall material, and it is micro- to belong to grease
Encapsulation techniques field.
Background technology
Butyric acid is a kind of short chain fatty acids present in enteron aisle, has and provides protection of intestinal mucosal barrier cells energy, improves small broiler chick
Structure adjusts the functions such as intestinal microbial balance, but the free property because of butyric acid, effumability and special stink, leads to it
It is unfavorable for production application.Precursor of the tributyrin as butyric acid is made of three molecule butyric acid and a molecule glycerine,
Chemical formula is C15H26O6, white nearly oily liquids is soluble in the organic reagents such as ethyl alcohol, in terms of overcoming butyric acid physicochemical property
Defect, while also there is the healthy development of improvement animal and bird intestines, improve body immunity, promote the work(such as nutrient digestion absorption
Can, thus as the potential substitute of antibiotics growth promoter.
However tributyrin presence is in a liquid state, extremely difficult the problems such as being dissolved in water, poor fluidity, is added in feed very not
It is convenient.In addition, tributyrin, there are the rancid sample smell of cheese, direct feeding influences the feeding performance of animal, these are lacked
Sunken presence limits promotion and application of the tributyrin in animal and fowl fodder.
Currently, being directed to its defect, a kind of new method is only disclosed：The patent application publication of Publication No. CN104106734A
A kind of tributyrin solid granulates type preparation and its preparation method and application, preparation process is as follows：By three butyric acid of liquid
Glyceride atomization is sprayed onto on the dry granular pattern white carbon silica gel of granulation, makes white carbon silica gel three butyric acid glycerine of full and uniform absorption
Ester forms silica gel supported tributyrin；By silica gel supported tributyrin sieving tributyrin solid-state
Grain shape preparation.Although this method is prepared simply, the performance of tributyrin is improved, because the slightly solubility of white carbon silica gel is led
Particle obtained is caused to have the shortcomings that dissolubility is poor, the application in terms of aquaculture industry is greatly limited.
Invention content
For existing defect, the invention discloses a kind of preparation methods of microcapsules, are with maltodextrin and cyclodextrin
For wall material maltodextrin and cyclodextrin are controlled using tributyrin as core material：The mass ratio of tributyrin be (2~
6)：1.
In one embodiment of the invention, each substance weight composition in the method is：Maltodextrin 16%~
24%, cyclodextrin 3%~4%, tributyrin 5%~12%；Emulsifier 4%~7%, water 54%~64%.
In one embodiment of the present invention, the maltodextrin includes one or more of the DE values between 5~25.
In one embodiment of the present invention, maltodextrin be by cornstarch, waxy corn starch, potato starch,
One or more of rice starch, tapioca and wheaten starch prepare for raw material.
In one embodiment of the present invention, the tributyrin is mixed with ethyl alcohol in advance, tributyrin with
Ethyl alcohol mass ratio is (1~3):1.
In one embodiment of the present invention, the emulsifier includes tween, sapn, Arabic gum, xanthans, soybean egg
In vain, one or more of monoglyceride etc..
In one embodiment of the invention, it the described method comprises the following steps：
(1) maltodextrin and cyclodextrin are added in distilled water, are uniformly mixed in 50~80 DEG C of heating water baths；
(2) tributyrin and emulsifier are added in the mixed solution obtained into (1), stirs；
(3) mixture obtained by (2) is sheared, homogeneous, spray drying, obtain tributyrin microscapsule powder
Product.
In one embodiment of the present invention, shear velocity is 8000~20000rpm, and shear time is 2~5min.
In one embodiment of the present invention, homogenization pressure is 30~40MPa, and homogenization cycles are 2~3 times.
In one embodiment of the present invention, the spray drying process parameters are as follows：180~185 DEG C of inlet air temperature, goes out
85~95 DEG C of air temperature, feed rate are 20~22mL/min.
The tributyrin microcapsules of the method preparation are also claimed in the present invention.
Application of the tributyrin microcapsules in terms of preparing feed is also claimed in the present invention.
Beneficial effects of the present invention：1. the present invention is that wall material three butyric acid of preparation are sweet using maltodextrin and cyclodextrin mixt
Grease microcapsules, raw material are easy to get, and preparation process is simple, easy to operate, easily realize industrialized production.2. preparation process of the present invention
In emulsion it is extremely stable, place 30 days it is not stratified.3. tributyrin microscapsule powder dissolving produced by the present invention
Property it is good, dissolving rear stability is up to 30 days, hence it is evident that improve tributyrin there are peculiar smell, be insoluble in water, poor fluidity etc.
Defect expands the application of tributyrin.4. the present invention carries out three fourths of inclusion using the property of cyclodextrin " assuming a false appearance, one is on intimate terms with sb "
Acid glyceride plays an important role the stability of tributyrin, is made full use of for carrier in microencapsulation grease
A kind of new means are provided.
Specific implementation mode
Emulsion and the dissolved stability of powdered oil are evaluated using direct observational method：By emulsion mounted in centrifugation
Guan Zhong stands place at room temperature, with the naked eye the delamination of routine observation system.
Influence of the 1 maltodextrin type of embodiment to tributyrin microcapsule stability
The preparation process of tributyrin powdered oil is performed as follows：
(1) maltodextrin and cyclodextrin are added in distilled water, are uniformly mixed in 50~80 DEG C of heating water baths；
(2) tributyrin and emulsifier are added in the mixed solution obtained into (1), stirs；
(3) by the mixture obtained by (2) with high-speed shearing machine under 8000~20000rpm (rotating speed improves step by step) interval
2~5min is sheared, high pressure homogenizer homogeneous 2~3 times under 30~40MPa pressure is then used, is finally spray-dried, is obtained
Tributyrin microscapsule powder product.Spray drying process parameters are as follows：180~185 DEG C of inlet air temperature, leaving air temp 85
~95 DEG C, feed rate is 20~22mL/min.
Wherein, each substance weight composition is：Maltodextrin 20%, cyclodextrin 3%, tributyrin 8%；Tween 5%,
Water 64%.Maltodextrin is chosen following several：DE=5,10,15,20,25.
Lotion made from maltodextrin by 5 kinds of difference DE values places 15 days not stratified, powder obtained at room temperature
Grease appearance is yellowish, not stratified after being dissolved in water placement 15 days, illustrates that its dissolubility and stability are fine.
Influence of the 2 maltodextrin additive amount of embodiment to tributyrin microcapsule stability
The preparation process of tributyrin powdered oil is carried out by embodiment 1, wherein maltodextrin chooses DE=10's
It carries out, each substance weight group ingredient presses following 5 groups of progress：
Experimental group 1：Maltodextrin 12%, cyclodextrin 3%, tributyrin 8%；Tween 5%, water 72%；
Experimental group 2：Maltodextrin 16%, cyclodextrin 3%, tributyrin 8%；Tween 5%, water 68%；
Experimental group 3：Maltodextrin 20%, cyclodextrin 3%, tributyrin 8%；Tween 5%, water 64%；
Experimental group 4：Maltodextrin 24%, cyclodextrin 3%, tributyrin 8%；Tween 5%, water 60%；
Experimental group 5：Maltodextrin 28%, cyclodextrin 3%, tributyrin 8%；Tween 5%, water 54%.
The solution obtained after above 5 groups of obtained lotions and powdered oil dissolving, after placing 15 days, phenomenon is shown in Table 1.Its
In, experimental group 5 is since maltodextrin content is higher, and in step (1), indissoluble solution influences the behaviour such as follow-up mixing, shearing, homogeneous
Make, therefore is not suitable for preparing tributyrin microcapsules.In experiment 1~4, after lotion made from experimental group 1 and powder dissolving
Obtained solution is unstable, hence it is evident that lamination occurs；And obtained after lotion made from experimental group 2~4 and powder dissolving
Stability of solution is preferable.
The stability of solution obtained after lotion made from the different maltodextrin additive amounts of table 1 and powder dissolving
Note：" -- " represents and does not carry out the metrics evaluation.
Influence of the 3 cyclodextrin additive amount of embodiment to tributyrin microcapsule stability
The preparation process of tributyrin powdered oil by embodiment 1 carry out, wherein each substance weight group ingredient press with
Lower 5 groups of progress：
Experimental group 1：Maltodextrin 20%, cyclodextrin 0%, tributyrin 8%；Tween 5%, water 67%；
Experimental group 2：Maltodextrin 20%, cyclodextrin 2%, tributyrin 8%；Tween 5%, water 65%；
Experimental group 3：Maltodextrin 20%, cyclodextrin 3%, tributyrin 8%；Tween 5%, water 64%；
Experimental group 4：Maltodextrin 20%, cyclodextrin 4%, tributyrin 8%；Tween 5%, water 63%；
Experimental group 5：Maltodextrin 20%, cyclodextrin 5%, tributyrin 8%；Tween 5%, water 62%.
The solution obtained after above 5 groups of obtained lotions and powdered oil dissolving, after placing 15 days, phenomenon is shown in Table 2.Its
In, 5 cyclodextrin content of experimental group is 5%, and supersaturation during being dissolved by heating in step (1), container substrate has precipitation residual
Stay undissolved, therefore, which does not carry out subsequent experimental.In experimental group 1~4, experimental group 1 is not added with cyclodextrin, merely with wheat
Bud dextrin is made wall material and is embedded to tributyrin, although powder stable homogeneous obtained is slightly good, compares experimental group 3
With 4, obviously it is layered after placing 15 days, therefore, cyclodextrin plays an important role the embedding of tributyrin, it may be possible to by
It is included in the special inner cavity of cyclodextrin.
The stability of solution obtained after lotion made from the different cyclodextrin additive amounts of table 2 and powder dissolving
Note：" -- " represents and does not carry out the metrics evaluation.
Influence of the different preparation methods of embodiment 4 to tributyrin microcapsule stability
The experimental group good to stability in embodiment 2~3 carries out the estimation of stability of longer time, is shown in Table 3.As a result it shows
Show, the microcapsules prepared in following embodiment are not stratified after placing 15 days and 30 days, show tributyrin obtained
Microcapsules do not occur the phenomenon that tributyrin exudation, and powder dissolubility and stability are good, are conducive to it in feed row
The application of industry.
The stability of solution obtained after lotion made from the different preparation methods of table 3 and powder dissolving
Although the present invention has been described by way of example and in terms of the preferred embodiments, it is not limited to the present invention, any to be familiar with this skill
The people of art can do various change and modification, therefore the protection model of the present invention without departing from the spirit and scope of the present invention
Enclosing be subject to what claims were defined.
Claims (10)
1. a kind of preparation method of microcapsules, which is characterized in that using maltodextrin and cyclodextrin as wall material, with tributyrin
For core material, maltodextrin and cyclodextrin are controlled：The mass ratio of tributyrin is (2~6)：1.
2. according to the method described in claim 1, it is characterized in that, each substance weight composition in the method is：Malt is pasted
Essence 16%~24%, cyclodextrin 3%~4%, tributyrin 5%~12%；Emulsifier 4%~7%, water 54%~
64%.
3. method according to claim 1 or 2, which is characterized in that the maltodextrin includes DE values between 5~25
One or more of maltodextrin ingredients.
4. according to the method described in claim 3, it is characterized in that, the maltodextrin is formed sediment by cornstarch, waxy corn
One or more of powder, potato starch, rice starch, tapioca and wheaten starch prepare for raw material.
5. method according to claim 1 or 2, which is characterized in that the tributyrin is mixed with ethyl alcohol in advance, and three
Glycerol monobutyralte is (1~3) with ethyl alcohol mass ratio:1.
6. according to the method described in claim 2, it is characterized in that, the emulsifier includes tween, sapn, Arabic gum, Huang
One or more of virgin rubber, soybean protein, monoglyceride etc..
7. according to any method of claim 1~6, which is characterized in that the described method comprises the following steps：
(1) maltodextrin and cyclodextrin are added in distilled water, are uniformly mixed in 50~80 DEG C of heating water baths；
(2) tributyrin and emulsifier are added in the mixed solution obtained into (1), stirs；
(3) mixture obtained by (2) is sheared, homogeneous, spray drying, obtain tributyrin microscapsule powder production
Product.
8. tributyrin microcapsules prepared by any the method for application claim 1~7.
9. tributyrin microcapsules according to any one of claims 8 answering in terms of preparing the product for adjusting intestinal microbial balance
With.
10. the feed containing tributyrin microcapsules described in claim 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810430318.1A CN108770948A (en) | 2018-05-08 | 2018-05-08 | It is a kind of using maltodextrin and cyclodextrin as the tributyrin microcapsules of wall material |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810430318.1A CN108770948A (en) | 2018-05-08 | 2018-05-08 | It is a kind of using maltodextrin and cyclodextrin as the tributyrin microcapsules of wall material |
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| CN108770948A true CN108770948A (en) | 2018-11-09 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113080457A (en) * | 2021-04-15 | 2021-07-09 | 南京纽邦生物科技有限公司 | Glyceryl tributyrate microcapsule powder and preparation method thereof |
| CN113332451A (en) * | 2021-06-02 | 2021-09-03 | 京津冀联创药物研究（北京）有限公司 | Volatile oil cyclodextrin inclusion compound and preparation method thereof |
| CN113950325A (en) * | 2019-06-06 | 2022-01-18 | 化合物解决方案有限公司 | Tributyrin compositions and methods |
| CN115363135A (en) * | 2021-05-19 | 2022-11-22 | 湖北浩华生物技术有限公司 | High-oil-loading water-dispersible tributyrin feed additive and preparation method thereof |
| CN115736112A (en) * | 2022-11-15 | 2023-03-07 | 西北农林科技大学 | Feed additive for reducing diarrhea rate of lactating calves and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709090A (en) * | 2005-07-08 | 2005-12-21 | 浙江大学 | Camellia oil micro capsule, and its preparing method and use |
| CN101301030A (en) * | 2008-05-22 | 2008-11-12 | 新奥（厦门）农牧发展有限公司 | Prescription of particles coated by butanoic acid derivative for feeding and preparing technique thereof |
| CN104106734A (en) * | 2014-06-27 | 2014-10-22 | 浙江大学 | Tributyrin solid granular preparation, and preparation method and application thereof |
| CN104509701A (en) * | 2015-01-12 | 2015-04-15 | 曹胜炎 | Preparation method for glycerol tributyrate microcapsule |
| CN107691877A (en) * | 2017-07-21 | 2018-02-16 | 广东越群海洋生物研究开发有限公司 | A kind of preparation method of the fresh-water fishes microcapsules opening material of zero starch |
-
2018
- 2018-05-08 CN CN201810430318.1A patent/CN108770948A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709090A (en) * | 2005-07-08 | 2005-12-21 | 浙江大学 | Camellia oil micro capsule, and its preparing method and use |
| CN101301030A (en) * | 2008-05-22 | 2008-11-12 | 新奥（厦门）农牧发展有限公司 | Prescription of particles coated by butanoic acid derivative for feeding and preparing technique thereof |
| CN104106734A (en) * | 2014-06-27 | 2014-10-22 | 浙江大学 | Tributyrin solid granular preparation, and preparation method and application thereof |
| CN104509701A (en) * | 2015-01-12 | 2015-04-15 | 曹胜炎 | Preparation method for glycerol tributyrate microcapsule |
| CN107691877A (en) * | 2017-07-21 | 2018-02-16 | 广东越群海洋生物研究开发有限公司 | A kind of preparation method of the fresh-water fishes microcapsules opening material of zero starch |
Non-Patent Citations (2)
| Title |
|---|
| 何家梁: "微胶囊三丁酸甘油酯的制备及促仔猪生长效果的研究", 《中国优秀硕士学位论文全文数据库》 * |
| 黄秀娟: "微胶囊化油脂的生产技术 ", 《粮油食品科技》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113950325A (en) * | 2019-06-06 | 2022-01-18 | 化合物解决方案有限公司 | Tributyrin compositions and methods |
| CN113080457A (en) * | 2021-04-15 | 2021-07-09 | 南京纽邦生物科技有限公司 | Glyceryl tributyrate microcapsule powder and preparation method thereof |
| CN113080457B (en) * | 2021-04-15 | 2023-04-18 | 南京纽邦生物科技有限公司 | Glyceryl tributyrate microcapsule powder and preparation method thereof |
| CN115363135A (en) * | 2021-05-19 | 2022-11-22 | 湖北浩华生物技术有限公司 | High-oil-loading water-dispersible tributyrin feed additive and preparation method thereof |
| CN113332451A (en) * | 2021-06-02 | 2021-09-03 | 京津冀联创药物研究（北京）有限公司 | Volatile oil cyclodextrin inclusion compound and preparation method thereof |
| CN115736112A (en) * | 2022-11-15 | 2023-03-07 | 西北农林科技大学 | Feed additive for reducing diarrhea rate of lactating calves and preparation method thereof |
| CN115736112B (en) * | 2022-11-15 | 2024-05-14 | 西北农林科技大学 | Feed additive for reducing diarrhea rate of lactating calves and preparation method thereof |
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