CN1087279A - Bioactive glass ceramic artificial bone and its preparation method - Google Patents
Bioactive glass ceramic artificial bone and its preparation method Download PDFInfo
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- CN1087279A CN1087279A CN 92113605 CN92113605A CN1087279A CN 1087279 A CN1087279 A CN 1087279A CN 92113605 CN92113605 CN 92113605 CN 92113605 A CN92113605 A CN 92113605A CN 1087279 A CN1087279 A CN 1087279A
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- 210000000988 bone and bone Anatomy 0.000 title abstract description 33
- 239000000919 ceramic Substances 0.000 title abstract description 5
- 239000005313 bioactive glass Substances 0.000 title abstract 2
- 239000010456 wollastonite Substances 0.000 claims abstract description 4
- 229910052882 wollastonite Inorganic materials 0.000 claims abstract description 4
- 229910052586 apatite Inorganic materials 0.000 claims abstract description 3
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims abstract description 3
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- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
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- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 235000007173 Abies balsamea Nutrition 0.000 claims description 2
- 244000283070 Abies balsamea Species 0.000 claims description 2
- 239000004858 Canada balsam Substances 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
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- 235000019322 gelatine Nutrition 0.000 claims description 2
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- 235000019698 starch Nutrition 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 2
- 238000006424 Flood reaction Methods 0.000 claims 1
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- 238000007731 hot pressing Methods 0.000 claims 1
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
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- 229910004261 CaF 2 Inorganic materials 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
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- 210000004409 osteocyte Anatomy 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
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- 229910052697 platinum Inorganic materials 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The invention relates to a bioactive glass ceramic artificial bone and a preparation method thereof. It contains microcrystal of apatite and wollastonite, has high biocompatibility, can form bone combining interface with bone tissue and is chemically stable. After the porous artificial bone implant is arranged in the bone, tissue fluid is easy to permeate into the material, so that the circulation condition is improved, fibrous tissues and bone tissues are favorable to grow in, the bone repair process is promoted, and the success rate of the operation is improved.
Description
The present invention is a kind of bio-active devitroceram artificial and preparation method thereof, belongs to the medical science surgery and uses the material field.
Sclerous tissueses such as the tooth of human body, skeleton because of disease, wound or lopsided cause damaged on a large scale, need repair or rescue with artificial material.This class material comprises metal, macromolecule and inorganic material.In inorganic material, the Hench[L.L.Hench of the U.S., et al:J.Biomed.Mater.Res.Symp.2, part 1,117-141(1971)] invention bio-vitric, have excellent biological compatibility, but intensity is low, and fragility is big, is a kind of fine and close shape material.The A-W glass ceramics of the Kokubo Tadashi of Japan [special public clear 57-191252], invention has good biocompatibility, stable chemical performance, and the comprcssive strength height is easy to advantages such as high-temperature sterilization, but needs high-pressure forming, makes through high temperature sintering again.Known in the world hydroxylapatite ceramic also needs under high pressure to be shaped, and makes through sintering.All these materials all belong to the ceramic of compact goods, and hardness is big, are difficult to do suitably finishing processing at operative site, because its hole is few, osseous tissue is difficult to the material internal of growing into.Medical research shows, as the artificial bone of bone filling and reparation, needs the hole and the porosity of appropriate size, be beneficial to the infiltration of tissue fluid and the osteocyte material deep of growing into, thereby make implantation body be seated in recipient bed in early days, promote the reparation of osseous tissue, improve success rate of operation.Aspect in addition, the clinical artificial bone that also requires to provide various forms, these are that the high-pressure molding method is difficult to realize.
The purpose of this invention is to provide a kind of bio-active devitroceram artificial and method for making thereof with different aperture degree and different shape.
The present invention is to be that (this glass micropowder is through high-temperature process for raw material with the glass micropowder, energy precipitation of phosphorus lime stone and wollastonite crystalline phase), add an amount of figuration porogen, in the normal pressure compacted under, sintering in the oxidizing atmosphere, and the bio-active devitroceram artificial that obtains having different aperture degree and form.
The chemical composition of above-mentioned glass dust is SiO
222～42, MgO 0.5～7, and CaO 33～60, P
2O
511～44, CaF
20.5～1, B
2O
30.1～3, Al
2O
30.5～1wt%.With the accurate weighing of analytically pure chemical reagent, mixing under 1450～1500 ℃, is melt into homogeneous melt with platinum crucible, cools off, pulverizes, sieves, and obtains the glass micropowder of granularity≤80 μ m.As primary raw material, adopt different process respectively, make all kinds of porous bio-active devitroceram artificials.
The present invention is the glass micropowder with above-mentioned composition, add figuration porogen (it is 5%～10% aqueous solution that the figuration porogen generally is made into concentration) to shaping and be degree, make granule with the shaking table rolling or with vibrosieve, Granulation Equipments, as required at 100～450 ℃, be preferably in the temperature range about 120 ℃ and kept 2～6 hours, reaching the purpose of intensive drying, in oxidizing atmosphere in 880～990 ℃ of sintering temperatures 2～6 hours.Described glass micropowder is 100: a 0.5～1(weight portion with the ratio of figuration porogen).The figuration porogen can be any one the aqueous solution in canada balsam, gelatin, arabic gum, methylcellulose, Polyethylene Glycol, the polyvinyl alcohol, also can be the macromolecular material that other has viscosity.Described oxidizing atmosphere is to point to feed fresh air or pure oxygen in the sintering furnace, and its oxygen flow is 0.5～1L/min.
By the granule shape, particularly spherical particle shape artificial bone that said method is produced, the back that implants is little to tissue stimulation, is difficult for bringing out sarcoma, is mainly used in the reparation of damaged filling of bone and osteanabrosis distortion back physiology profile.With their heeling-ins in vivo, can form tightly packedly, it piles up hole for homergy provides necessary passage, and fibrous tissue and osseous tissue are grown into easily.
The present invention also can adopt high resilience foam, as polyurethane foam plastics, polyethylene foams is support, be immersed in the synthetic according to the above ratio mud of glass micropowder and figuration porogen, extruding makes mud be full of hole repeatedly, is adsorbed on the support, taking-up is at 100～450 ℃, be preferably and keep 2～6 hours dryings in 400～450 ℃ of temperature ranges, Organic substance is discharged, in oxidizing atmosphere in 880～990 ℃ of sintering 2～6 hours.But described foam plastics preprocess becomes required form, is convenient to behind the sintering shape.
By the foam type artificial bone piece that said method makes, mainly apply to the large tracts of land bone and lack to repair, its porosity and porosity are all bigger, help fiber and osseous tissue is grown into.
The present invention can also paraffin be the figuration porogen, is about to the glass micropowder of above-mentioned composition and heating paraffin (dissolving to paraffin) mix homogeneously, with hot injection moulding machine or moulding by casting.In oxidizing atmosphere, in 100～450 ℃ of scopes, be preferably and keep 2～6 hours de-waxings in 400～450 ℃ of scopes, again 880～990 ℃ of sintering 2～6 hours in oxidizing atmosphere.Described glass micropowder is 100: a 10～20(weight portion with the ratio of paraffin).
Biological active glass ceramic cynodontins such as the shape that said method can obtain crystallization is equivalent to labial teeth, canine tooth, the root of the tooth of grinding one's teeth in sleep, as planting root of the tooth in the alveolar bone, can replace natural tooth root to retain in the alveolar bone, reduce or delay the absorption and the atrophy of alveolar bone, keep its height and shape, help removable denture maintenance and stable.
The also available paraffin of the present invention is the figuration porogen, the glass micropowder is mixed in the paraffin of fusing, stir, add foaming agent, casting or hot forming, in oxidizing atmosphere,, be preferably 400～450 ℃ and keep 2～6 hours de-waxings, then 880～990 ℃ of following sintering 2～6 hours in oxidizing atmosphere in 100～450 ℃.Described glass micropowder is 100: a 10～20(weight portion with the ratio of paraffin), paraffin is 100: 2～15(weight portion with the ratio of foaming agent).Described foaming agent is any one or a few the mixture in dextrin, starch, naphthalene, poly-methylcellulose, polyurethane foam plastics, polyvinyl alcohol, the carbamide.
Also can make foam type artificial bone piece with said method.
Adopt above-mentioned the whole bag of tricks can produce difformity, porous bio-active devitroceram artificial, contain apatite and wollastonite crystallization, its porosity is 20～70VoL%, and the aperture is 10～1000 μ m.
The present invention compared with prior art has following advantage:
(1) porous all kinds of artificial bones provided by the invention implanted 1 month, and fibrous tissue has promptly been grown in intergranular space and the granule inner pore, and 3 months new bones space of growing into the material close attachment, and has blood vessel and haversian system to generate.The clinical jawbone that is used for lacks reparation, and alveolar ridge increases, the periodontal bone defect healing, and artificial nasus incurvus beauty treatment all can obtain good result.
(2) the present invention adopts the normal pressure molding, methods such as oxidizing atmosphere sintering, and equipment is simple, and cost is low, easy operating.And can obtain the artificial bone of various difformities and different aperture degree, can satisfy clinical various special requirements.
(3) the porous type artificial bone is revised processing easily at operative site.
(4) be convenient to use.Preparation method of the present invention also can be used for making other porous ceramics product.
Embodiment one:
Taking by weighing granularity is the following glass micropowder 100g of 74 μ m, adds the polyvinyl alcohol water solution of 10wt%, stir repeatedly, and be to spend to shaping, putting rolls on the vibrosieve is shaped.Suitably add dry powder, particle size is grown up.This granule in 120 ℃ of dryings 4 hours, then under the condition of bubbling air, 900 ℃ of sintering 6 hours, can be obtained white spheroidal particle.Wherein pore-size is 30～80 μ m, and porosity is about 20%, piles up porosity≤30VoL%, is used to increase the atrophy alveolar ridge, filling exodontia nest, filling bone cavity etc., satisfactory effect.
Embodiment two:
With granularity is that glass micropowder 200g below the 20 μ m adds Polyethylene Glycol (molecular weight 10,000) 50g, stir into distributed slurry, high-elastic polyurethane foam plastic is cut into the mandibular bone shape, immerse in the slip, extruding repeatedly, air-out makes the plastic foam hole be full of by slip, take out cold to half-dried, repeat aforesaid operations.The material piece that obtains 120 ℃ of dryings 4 hours, is put into Muffle furnace, and aerating oxygen, flow are 0.2L/min, keep 2 hours at 450 ℃, are warming up to 900 ℃ and keep 4 hours, obtain the artificial mandibular bone of porous type, can be used as to repair and use.
Embodiment three:
With granularity is the glass micropowder 100g of≤74 μ m, adds in the fused refined paraffin wax of 10g in batches, heats while stirring, and until stirring, temperature remains on about 70 ℃.Pour into while hot in the heating cylinder of hot injection moulding machine, under 80 ℃ of temperature,, be expressed in the root of the tooth shape mould, cooling slightly, the demoulding the mixture of glass dust and paraffin.Kept 2 hours at 450 ℃, de-waxing in oxidizing atmosphere, heat temperature raising to 920 ℃ kept 4 hours, lowered the temperature with stove, promptly obtained porous type glass ceramics artificial tooth root, and its porosity is about about 15VoL%, about 20～60 μ m of hole diameter.
Embodiment four:
Glass micropowder 100g with granularity≤74 μ m, join in the fused refined paraffin wax of 20g in batches, add the porous polyethylene foam plastics chip of 2g simultaneously through pulverization process, be heated to 120 ℃, fully mix it is poured in the artificial bone model of the system of giving, to be cooled to sclerosis, demoulding finishing.Then, be heated to 450 ℃, in oxidizing atmosphere, keep 4 hours de-waxings, then, be heated to 920 ℃, kept 4 hours, be cooled to room temperature with stove with 5 ℃/component velocity with 3 ℃/component velocity.The artificial bone porosity that obtains is about 40VoL%, about 50～500 μ m of its hole diameter scope.
Claims (5)
1; a kind of method for making of bio-active devitroceram artificial; with the glass micropowder is raw material; often molded; dry; sintering and make bio-active devitroceram artificial; it is characterized in that adding the figuration porogen; the glass micropowder is 100: 0.5～1 (weight portion) with the ratio of figuration porogen; the figuration porogen is a canada balsam; gelatin; methylcellulose; arabic gum; Polyethylene Glycol; the aqueous solution of any one in the polyvinyl alcohol; sintering is to carry out in oxidizing atmosphere; oxygen flow is 0.5～1L/min, and manufacturing process is a vibrosieve; shaking table rolls or the comminutor pelletize.
2, method for making according to claim 1 is characterized in that manufacturing process is that glass micropowder and figuration porogen are modulated into flowable mud, floods, is adsorbed on polyurethane foam or the polyethylene elastic support.
3, method for making according to claim 1 is characterized in that the figuration porogen is a paraffin, and the glass micropowder is 100: a 10～20(weight portion with the ratio of figuration porogen), manufacturing process adopts hot pressing casting mold or moulding by casting.
4, preparation method according to claim 3, it is characterized in that adding foaming agent, paraffin is 100: 2～5(weight portion with the ratio of foaming agent), foaming agent is any one or a few the mixture in starch, dextrin, carbamide, hydrogen peroxide, naphthalene, poly-methylcellulose, polyvinyl alcohol, the polyurethane foam plastics.
5, the product that makes according to claim 1,2,3,4 described methods is for containing the porosity 20～70VoL% of apatite and wollastonite crystalline phase, the bio-active devitroceram artificial of aperture 10～1000 μ m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92113605 CN1087279A (en) | 1992-11-27 | 1992-11-27 | Bioactive glass ceramic artificial bone and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92113605 CN1087279A (en) | 1992-11-27 | 1992-11-27 | Bioactive glass ceramic artificial bone and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1087279A true CN1087279A (en) | 1994-06-01 |
Family
ID=4946506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92113605 Pending CN1087279A (en) | 1992-11-27 | 1992-11-27 | Bioactive glass ceramic artificial bone and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1087279A (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1303953C (en) * | 1996-09-19 | 2007-03-14 | 美国生物材料公司 | Composition and method for acceleration of wound and burn healing |
| CN101328021B (en) * | 2008-07-22 | 2010-12-08 | 内蒙古科技大学 | Porous devitrified glass and manufacturing method thereof |
| CN102060444A (en) * | 2010-11-10 | 2011-05-18 | 内蒙古科技大学 | Foam glass ceramic and preparation method thereof |
| CN102470194A (en) * | 2009-07-10 | 2012-05-23 | 百傲图科技有限公司 | Devices and methods for tissue engineering |
| CN102488927A (en) * | 2011-12-16 | 2012-06-13 | 成都迪康中科生物医学材料有限公司 | Bone repairing material and preparation method thereof |
| CN102725006A (en) * | 2009-10-07 | 2012-10-10 | 百傲图科技有限公司 | Devices and methods for tissue engineering |
| CN103787581A (en) * | 2014-01-24 | 2014-05-14 | 邝大军 | Preparation method for applying urea and polyethylene glycol blend to bioactive glass bone repair material pore-forming process |
| CN103920193A (en) * | 2014-04-04 | 2014-07-16 | 北京大学口腔医院 | Preparation method of bioactive factor loaded bone-like ceramic composite material |
| CN105218081A (en) * | 2015-10-12 | 2016-01-06 | 中国科学院上海硅酸盐研究所 | A kind of with the preparation method of nonmetal boride for sintering aid Calucium Silicate powder biological ceramics |
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| CN105935453A (en) * | 2016-05-20 | 2016-09-14 | 杨景周 | Natural wollastonite mineral biological ceramic bone scaffold material and preparation method thereof |
| CN110101904A (en) * | 2019-06-20 | 2019-08-09 | 北京幸福益生再生医学科技有限公司 | A kind of regenerated degradable regenerative medical material of promotion tissue in situ and preparation method thereof |
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-
1992
- 1992-11-27 CN CN 92113605 patent/CN1087279A/en active Pending
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1303953C (en) * | 1996-09-19 | 2007-03-14 | 美国生物材料公司 | Composition and method for acceleration of wound and burn healing |
| CN101328021B (en) * | 2008-07-22 | 2010-12-08 | 内蒙古科技大学 | Porous devitrified glass and manufacturing method thereof |
| CN102470194B (en) * | 2009-07-10 | 2014-07-23 | 百傲图科技有限公司 | Devices and methods for tissue engineering |
| CN102470194A (en) * | 2009-07-10 | 2012-05-23 | 百傲图科技有限公司 | Devices and methods for tissue engineering |
| CN102470195A (en) * | 2009-07-10 | 2012-05-23 | 百傲图科技有限公司 | Devices and methods for tissue engineering |
| CN102470195B (en) * | 2009-07-10 | 2014-07-23 | 百傲图科技有限公司 | Devices and methods for tissue engineering |
| CN102725006A (en) * | 2009-10-07 | 2012-10-10 | 百傲图科技有限公司 | Devices and methods for tissue engineering |
| CN102725006B (en) * | 2009-10-07 | 2014-10-22 | 百傲图科技有限公司 | Porosity tissue scaffold |
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| CN102060444B (en) * | 2010-11-10 | 2012-09-26 | 内蒙古科技大学 | Foam glass ceramic and preparation method thereof |
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