CN108707143B - 一种dpp-4抑制剂及其制备和在糖尿病中的应用 - Google Patents
一种dpp-4抑制剂及其制备和在糖尿病中的应用 Download PDFInfo
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- CN108707143B CN108707143B CN201810672593.4A CN201810672593A CN108707143B CN 108707143 B CN108707143 B CN 108707143B CN 201810672593 A CN201810672593 A CN 201810672593A CN 108707143 B CN108707143 B CN 108707143B
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- dpp
- compound
- pharmaceutically acceptable
- inhibitor
- quinolin
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物 | IC<sub>50</sub>(nM) |
YZJ-B11 | 1.12 |
YZJ-B12 | 0.93 |
YZJ-B14 | 0.94 |
omarigliptin | 2.2 |
Sitagliptin | 15.4 |
Claims (5)
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GB0315494D0 (en) * | 2003-07-02 | 2003-08-06 | Biofocus Plc | Compounds which bind to the active site of protein kinase enzymes |
CN101208306A (zh) * | 2005-05-23 | 2008-06-25 | 日本烟草产业株式会社 | 吡唑化合物和含有这些吡唑化合物的糖尿病治疗剂 |
PL2376447T3 (pl) * | 2009-01-09 | 2018-04-30 | Orchid Pharma Limited | Inhibitory dipeptydylopeptydazy iv |
WO2011025006A1 (ja) * | 2009-08-31 | 2011-03-03 | 日本ケミファ株式会社 | Gpr119作動薬 |
US9174980B2 (en) * | 2012-01-31 | 2015-11-03 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as inhibitors of leukotriene production |
CN104744435B (zh) * | 2013-12-25 | 2017-03-01 | 上海医药工业研究院 | 喹啉类化合物、其盐、其中间体、制备方法及应用 |
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