CN108245608A - A kind of effective Chinese herbal medicine for inhibiting tumour and preparation method thereof - Google Patents
A kind of effective Chinese herbal medicine for inhibiting tumour and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of effective Chinese herbal medicines for inhibiting tumour and preparation method thereof, and the ingredient of the Chinese herbal medicine and the parts by weight of various composition are：0.5~3 part of 20~30 parts of Radix Astragali, 15~25 parts of Radix Notoginseng, 10~20 parts impetuous, 10~15 parts of tulip bulb, 5~10 parts of perilla seed, 1~3 part of stiff silkworm and Reishi sporule.The application inhibits the effect of tumour by by a certain amount of Radix Astragali, Radix Notoginseng, the seed of garden balsam and tulip bulb synergy, greatly improving, and four are used in combination to be used alone than its any one tumour rate is inhibited to improve 30~70%, highly significant.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of effective Chinese herbal medicine for inhibiting tumour and its preparation side
Method.
Background technology
Cancer belongs to one of a kind of current extremely common disease type and the highest disease of the death rate, therefore, for
The treatment of various types of tumours is always the hot spot of research, while is also difficult point.
It is generally known that the medicines such as Western medicine and chemicotherapy or method can generate human body larger side effect, seriously
Influence the health status of human body.And the toxic side effect of Chinese medicine is smaller, therefore Chinese medicine has been increasingly becoming the hot spot selection of researchers.
Such as application No. is the patents of 200510049364.X to disclose a kind of Chinese medicine for the treatment of cancer, including fresh Sculellaria barbata and fresh
Oldenlandia diffusa.But its curative effect and toxic side effect are indefinite.The applicant studies for many years for the herbal treatment of neoplastic diseases,
And the experiment and numerous data comparisons passed through many times is found that it is respectively provided with kinds of tumors type the suppression cancer of significant curative effect
Drug.
Invention content
In view of this, it is existing to overcome the present invention provides a kind of effective Chinese herbal medicine for inhibiting tumour and preparation method thereof
Many deficiencies in technology.
The purpose of the present invention is be achieved through the following technical solutions：
A kind of preparation method of the Chinese herbal medicine of effective inhibition tumour, the method are as follows：
Step 1: each ingredient of Chinese herbal medicine, the ingredient of Chinese herbal medicine and the parts by weight of various composition are weighed in proportion
For：20~30 parts of Radix Astragali, 15~25 parts of Radix Notoginseng, 10~20 parts impetuous, 10~15 parts of tulip bulb, 10~20 parts of Rhizoma Chuanxiong, oyster 5
~10 parts, 10~15 parts of earthworm, 1~3 part of Radix Codonopsis, 10~15 parts of Paris polyphylla, 1~3 part of purslane, 1~3 part of black nightshade, rheum officinale 20~
10~100 parts of 30 parts, 0.2~1 part of borneol, 5~10 parts of perilla seed, 1~3 part of stiff silkworm, 0.5~3 part of Reishi sporule and water, and will
The ingredient of various Chinese herbal medicines is ground into the powder that grain size is less than 2mm respectively；
It is impetuous：Refined honey is added in the impetuous powder of formula ratio and is mixed thoroughly, and place it in pot, with being fried with slow fire not
Viscous hand, takes out, natural cooling；The seed of garden balsam and the mass ratio of refined honey are：1：(2~3)；Radix Astragali：In Milkvetch Root plus white wine is mixed
It is even, and place it in pot, with when being fried with slow fire wine dry doubling and having detonans, take out, natural cooling, the mass ratio of Radix Astragali and white wine
For：1：(15~20)；
Step 2: will the Reishi sporule of formula ratio and oyster add in the water of formula ratio at 90~100 DEG C stirring 20~
30 minutes, Radix Astragali, Radix Notoginseng, the seed of garden balsam, Rhizoma Chuanxiong and the tulip bulb of formula ratio are then added in, continues to stir at 90~100 DEG C anti-
3~5h is answered, obtains semi-finished product；
Continue in obtained semi-finished product 90~100 Step 3: the stiff silkworm of formula ratio and borneol are added in step 2
It is stirred to react at DEG C 20~30 minutes, in the whipping process, is slowly added to the perilla seed of formula ratio, earthworm, Radix Codonopsis, Paris polyphylla, horse
Bitterroot, black nightshade and Rhubarb continue stirring 10~20 minutes after adding, filtering, obtain to inhibit the Chinese herbal medicine of tumour.
Further, the Chinese herbal medicine further includes 2~5 parts of Sculellaria barbata, then when containing Sculellaria barbata in Chinese herbal medicine, will match
The Sculellaria barbata powder just measured mixes in step 3 with perilla seed, earthworm, Radix Codonopsis, Paris polyphylla, purslane, black nightshade and Rhubarb
Afterwards, it is slowly added to.
Further, the Chinese herbal medicine further includes 4~9 parts of Sculellaria barbata, then when containing the fruit of glossy privet in the Chinese herbal medicine,
The fruit of glossy privet powder of formula ratio is sprinkled into step 3 in system, is then stirred to react at 90~100 DEG C 20~30 minutes,
Add perilla seed, earthworm, Radix Codonopsis, Paris polyphylla, purslane, black nightshade and Rhubarb.
A kind of effective Chinese herbal medicine for inhibiting tumour, the ingredient of the Chinese herbal medicine and the parts by weight of various composition are：It is yellow
20~30 parts of stilbene, 15~25 parts of Radix Notoginseng, 10~20 parts impetuous, 10~15 parts of tulip bulb, 10~20 parts of Rhizoma Chuanxiong, oyster 5~10
Part, 10~15 parts of earthworm, 1~3 part of Radix Codonopsis, 10~15 parts of Paris polyphylla, 1~3 part of purslane, 1~3 part of black nightshade, 20~30 parts of rheum officinale,
0.5~3 part of 0.2~1 part of borneol, 5~10 parts of perilla seed, 1~3 part of stiff silkworm and Reishi sporule.
Further, the ingredient of the Chinese herbal medicine and the parts by weight of various composition are：23~27 parts of Radix Astragali, Radix Notoginseng 18
~22 parts, 14~16 parts impetuous, 12~13 parts of tulip bulb, 13~17 parts of Rhizoma Chuanxiong, 6~8 parts of oyster, 13~14 parts of earthworm, party
2 parts of ginseng, 12~14 parts of Paris polyphylla, 2 parts of purslane, 2 parts of black nightshade, 23~27 parts of rheum officinale, 0.4~0.6 part of borneol, perilla seed 6~7
1~2 part of part, 2 parts of stiff silkworm and Reishi sporule.
Further, the ingredient of the Chinese herbal medicine further includes Sculellaria barbata, and the parts by weight of Sculellaria barbata are 2~5 parts.
Further, the parts by weight of the Sculellaria barbata are 3~4 parts.
Further, the ingredient of the Chinese herbal medicine further includes ternateleaf rabdosia herb, and the parts by weight of ternateleaf rabdosia herb are 0.5~2 part, excellent
Select 1 part.
Further, the ingredient of the Chinese herbal medicine further includes the fruit of glossy privet, and the parts by weight of the fruit of glossy privet are 4~9 parts.
Further, the parts by weight of the fruit of glossy privet are 6~7 parts.
The present invention at least has the advantages that：
The present invention provides a kind of effective Chinese herbal medicine and preparation method thereof for inhibiting tumour, the application is by will be a certain amount of
Radix Astragali, Radix Notoginseng, the seed of garden balsam, Rhizoma Chuanxiong and tulip bulb synergy greatly improve the effect for inhibiting tumour, and four are used in combination ratio
Its any one, which is used alone, inhibits tumour rate to improve 30~60%, highly significant；Pass through earthworm, Paris polyphylla, purslane, dragon
Certain herbaceous plants with big flowers, the addition of rheum officinale, additionally it is possible to 10% or so cancer resistant effect is promoted, excellent resultant effect is realized in collective effect effect,
Cancer resistant effect is also further improved by Reishi sporule, Radix Codonopsis and the addition of oyster, for the trouble struggled for a long time with cancer
Person, significant effect can enhance the disease resistance of patient to a certain extent.Stiff silkworm, borneol, perilla seed and ternateleaf rabdosia herb and its
Its component immixture can effectively promote 2~5% inhibition tumour rate, and the poison that can effectively weaken Chinese herbal medicine of the present invention is secondary
Effect, and can further promote cancer resistant effect.The poison that Sculellaria barbata and the fruit of glossy privet also can further reduce Chinese herbal medicine of the present invention is secondary
Effect, and it is beneficial to eliminating tumour.
Specific embodiment
The technical solution in the embodiment of the present invention is clearly and completely described below, it is clear that described embodiment
It is part of the embodiment of the present invention, instead of all the embodiments.The detailed description of the embodiment of the present invention presented below is simultaneously
The range of claimed invention is not intended to be limiting, but is merely representative of the selected embodiment of the present invention.
Embodiment 1
A kind of effective Chinese herbal medicine for inhibiting tumour, the ingredient of the Chinese herbal medicine and the parts by weight of various composition may include
But it is not limited to weight proportion in detail below：(1) 20 parts of Radix Astragali, 25 parts of Radix Notoginseng, 10 parts impetuous, 15 parts of tulip bulb, Rhizoma Chuanxiong 10
Part, 10 parts of oyster, 10 parts of earthworm, 3 parts of Radix Codonopsis, 10 parts of Paris polyphylla, 3 parts of purslane, 1 part of black nightshade, 30 parts of rheum officinale, 0.2 part of borneol, purple
0.5 part of 5 parts of perillaseed, 3 parts of stiff silkworm and Reishi sporule.(2) 30 parts of Radix Astragali, 15 parts of Radix Notoginseng, 20 parts impetuous, 10 parts of tulip bulb, river
20 parts of rhizome of chuanxiong, 5 parts of oyster, 15 parts of earthworm, 1 part of Radix Codonopsis, 15 parts of Paris polyphylla, 1 part of purslane, 3 parts of black nightshade, 20 parts of rheum officinale, 1 part of borneol,
3 parts of 10 parts of perilla seed, 1 part of stiff silkworm and Reishi sporule；(3) 23 parts of Radix Astragali, 22 parts of Radix Notoginseng, 14 parts impetuous, 13 parts of tulip bulb, river
13 parts of rhizome of chuanxiong, 8 parts of oyster, 13 parts of earthworm, 2 parts of Radix Codonopsis, 14 parts of Paris polyphylla, 2 parts of purslane, 2 parts of black nightshade, 23 parts of rheum officinale, borneol 0.6
Part, 6 parts of perilla seed, 2 parts of stiff silkworm and 2 parts of Reishi sporule；(4) 27 parts of Radix Astragali, 18 parts of Radix Notoginseng, 16 parts impetuous, 12 parts of tulip bulb,
17 parts of Rhizoma Chuanxiong, 6 parts of oyster, 14 parts of earthworm, 2 parts of Radix Codonopsis, 12 parts of Paris polyphylla, 2 parts of purslane, 2 parts of black nightshade, 27 parts of rheum officinale, borneol 0.4
Part, 7 parts of perilla seed, 2 parts of stiff silkworm and 1 part of Reishi sporule；(5) 25 parts of Radix Astragali, 20 parts of Radix Notoginseng, 15 parts impetuous, 12 parts of tulip bulb,
15 parts of Rhizoma Chuanxiong, 7 parts of oyster, 14 parts of earthworm, 2 parts of Radix Codonopsis, 13 parts of Paris polyphylla, 2 parts of purslane, 2 parts of black nightshade, 25 parts of rheum officinale, borneol 0.5
Part, 6 parts of perilla seed, 2 parts of stiff silkworm and 1.5 parts of Reishi sporule.
As further preferred embodiment, the ingredient of the Chinese herbal medicine further includes Sculellaria barbata, and the weight of Sculellaria barbata
Number is 2~5 parts, preferably 3~4 parts, such as 3.5 parts.
As further preferred embodiment, the ingredient of the Chinese herbal medicine further includes ternateleaf rabdosia herb, and the weight of ternateleaf rabdosia herb
Number is 0.5~2 part, preferably 1 part.
As further preferred embodiment, the ingredient of the Chinese herbal medicine further includes the fruit of glossy privet, and the weight of the fruit of glossy privet
Number is 4~9 parts, preferably 6~7 parts, such as 6.5 parts.
Embodiment 2
A kind of preparation method of the Chinese herbal medicine of effective inhibition tumour, described method includes following steps：
Step 1, each ingredient for weighing Chinese herbal medicine in proportion, i.e. Radix Astragali, Radix Notoginseng, the seed of garden balsam, tulip bulb, Rhizoma Chuanxiong, oyster,
Earthworm, Radix Codonopsis, Paris polyphylla, purslane, black nightshade, rheum officinale, borneol, perilla seed, stiff silkworm, Reishi sporule and water, specific ratio is for example
Shown in embodiment 1, restriction is not repeated herein；And the ingredient of various Chinese herbal medicines is ground into powder of the grain size less than 2mm respectively；
It is impetuous：Refined honey is added in impetuous powder and is mixed thoroughly, and place it in pot, it is tack-free with being fried with slow fire, it takes
Go out, natural cooling；The seed of garden balsam and the mass ratio of refined honey are：1：2.5；Radix Astragali：In Milkvetch Root plus white wine is mixed thoroughly, and put
In in pot, with when being fried with slow fire wine dry doubling and having detonans, take out, natural cooling, the mass ratio of Radix Astragali and white wine is：1:17；
Reishi sporule and oyster are added to the water and are stirred 25 minutes at 100 DEG C by step 2, then add in and are handled through white wine
The Radix Astragali of frying, Radix Notoginseng, Rhizoma Chuanxiong, through the processed impetuous and tulip bulb of refined honey, continue to be stirred to react at 90~100 DEG C
3~5h；
Stiff silkworm and borneol are added in Step2 and continue to be stirred to react at 100 DEG C 25 minutes by step 3, stirred at this
Journey is slowly sprinkled into perilla seed, earthworm, Radix Codonopsis, Paris polyphylla, purslane, black nightshade and Rhubarb, continues 15 points of stirring after adding
Clock, filtering, obtains the Chinese herbal medicine that can inhibit tumour.
As further preferred embodiment, if containing Sculellaria barbata in the Chinese herbal medicine, by Sculellaria barbata powder in step
After being mixed in rapid 3 with several drugs powder such as perilla seeds, it is slowly added to.
As further preferred embodiment, if containing ternateleaf rabdosia herb in the Chinese herbal medicine, worn into step 1
Powder adds in together with Radix Astragali etc. in step 2.
As further preferred embodiment, if containing the fruit of glossy privet in the Chinese herbal medicine, by fruit of glossy privet powder in step
It is then stirred to react at 100 DEG C 25 minutes, then add in addition system before a variety of drug powders such as addition perilla seed in rapid 3
Enter the drug powders such as perilla seed.
Embodiment 3：It uses
When specifically used, the Chinese herbal medicine of the inhibition tumour in embodiment 1 takes 2~3 daily each taking 0.2~1mL
It is secondary, it is carried out with specific reference to age, state of an illness etc. suitable for adjustment.
Embodiment 4：Toxotest
1st, the hair of experiment mice abdomen shaves off, and forms the exposed portion of circle that diameter is about 1~2cm, then will be of the invention
In the Chinese herbal medicine of inhibition tumour be applied to the exposed portion of the circle, observed after smearing 3~5 times, 3 days daily, find the work of mouse
Power and the color in the exposed portion of mouse skin do not change, also without any allergic reaction.
2nd, the Chinese herbal medicine of the inhibition tumour in the present invention for mouse is gavaged, 3 times a day, gavages 1ml every time, continuously
5 day week is observed, as a result, it has been found that, weight, vigor of mouse etc. do not change.
It should be noted that the toxotest in the present embodiment is by being compared to obtain with blank control group
Conclusion.
Embodiment 5
Experiment material：Kun Ming mice, weight 18-22g, male and female dual-purpose, by The Fourth Military Medical University's Experimental Animal Center
It provides.
Knurl strain：The knurl strain type of experiment be S180, H22, HAC and ARS, wherein, S180, H22 are given birth to by The Fourth Military Medical University
Change teaching and research room to provide；HAC and ARS is provided by institute of oncology of medical courses in general institute, Henan.
Animal house and feed：Animal house temperature is controlled at 18~22 DEG C, and light is good；Feed is solid feed, by the 4th
Army medical university's Experimental Animal Center provides.
Test method：After selection inoculation knurl strain 7 days, the vigorous no diabrosis of tumour growth and the preferable knurl source of animal general status
Animal, cervical dislocation are put to death, are fixed on stencil plate, sterilizing operation position, cut skin, and the good tumor tissue of growth selection is cut
Into 2-3mm2Fritter, ground with glass tissue homogenizer, every milliliter of 2.5*10 containing oncocyte be diluted to sterile saline7
Suspension, choose several of small white mouse, male and female dual-purpose, tumor cell suspension is subcutaneously injected in armpit position on the right side of each mouse forelimb
0.2ml is divided into negative control group (brine group), positive controls (cyclophosphamide), experimental group large dosage group (this hair after 24 hours
The Chinese herbal medicine 0.2g/kg of inhibition tumour in bright) and the experimental group small dose group (Chinese herbal medicine of the inhibition tumour in the present invention
0.1g/kg), it is administered to each group tumour mice lavage, volume 20ml/kg, is administered 10 days altogether respectively, after being discontinued 24 hours
Dead animal, weighs, and removes tumor mass and claims its knurl weight, and tumor control rate is calculated by therapeutic evaluation formula.I.e.：Tumor control rate=
(C-T)/C*100%, wherein, C is control group average knurl weight, and T is administration group average knurl weight.Wherein experimental group large dosage group and small
Components by weight is in dosage group：25 parts of Radix Astragali, 20 parts of Radix Notoginseng, 15 parts impetuous, 12 parts of tulip bulb, 15 parts of Rhizoma Chuanxiong, oyster 7
Part, 14 parts of earthworm, 2 parts of Radix Codonopsis, 13 parts of Paris polyphylla, 2 parts of purslane, 2 parts of black nightshade, 25 parts of rheum officinale, 0.5 part of borneol, 6 parts of perilla seed,
1.5 parts of 2 parts of stiff silkworm, 6.5 parts of the fruit of glossy privet, 1 part of ternateleaf rabdosia herb, 3.5 parts of Sculellaria barbata and Reishi sporule.
1~4 is the results are shown in Table, is respectively the tumour inhibiting rate of different knurl strain types in four tables.
The Chinese herbal medicine of inhibition tumour in 1 present invention of table is to the inhibiting effect of mice transplanted tumor S180
Compared with negative control group：P ＜ 0.01
The Chinese herbal medicine of inhibition tumour in 2 present invention of table is to the inhibiting effect of mice transplanted tumor H22
Compared with negative control group：P ＜ 0.01
The Chinese herbal medicine of inhibition tumour in 3 present invention of table is to the inhibiting effect of mice transplanted tumor HAC
Compared with negative control group：P ＜ 0.01
Table 4 is to the inhibiting effect of mice transplanted tumor ARC
Compared with negative control group：P ＜ 0.01
By above-mentioned table 1~4 it is found that the Chinese herbal medicine of the inhibition tumour in the present invention has significantly the tumour of four types
Tumor-inhibiting action, and 70% or so is reached to the tumor-inhibiting action of the knurls strain such as H22, HAC and ARS, it has been more than positive control ring phosphinylidyne
The effect of amine.And the Chinese herbal medicine in the present invention also has dose dependent increase, i.e. and dosage increases the enhancing of its tumor-inhibiting action.
In addition, the applicant is also by Radix Astragali, Radix Notoginseng, the seed of garden balsam, Rhizoma Chuanxiong, earthworm, Radix Codonopsis, Paris polyphylla, purslane, black nightshade, big
The independent gavage such as Huang, borneol, stiff silkworm, tulip bulb, the fruit of glossy privet, Sculellaria barbata is inoculated with the small white mouse of tumour cell, as a result its tumor suppression
Rate is respectively less than 10%, and any cancer resistant effect is not almost seen in also several individual effect；And by Radix Astragali, Radix Notoginseng, the seed of garden balsam and light
Arrowhead acts on, and can be promoted to 50%~55% to the tumour inhibiting rate of mice transplanted tumor ARC, be further added by other components, presses down
Cancer rate is further promoted to the effect shown in above table.
Embodiment 6：Influence to mouse tumor cell growth in vitro
Crude drug in whole 3g is gone to add distilled water 100ml boilings twice, 30 minutes every time, the filtrate conduct of 0.03g/ml was made in filtration
Mother liquor is spare.
1st, to the influence of mouse H22 liver cancer cells growth in vitro
Take the H22 ascites hepatoma cells of 7 days after inoculation, centrifugation discards supernatant liquid, washed with RPMI1640 culture solutions it is secondary,
It is prepared into 1*10 again7The cell suspension of R/L is dilute by drug with RPMI1640 culture solutions of the pH6.8 containing 10% calf serum
Required various concentration are interpreted into, set up ten parallel pipes, often pipe adds in 0.5ml cell suspensions, is then respectively adding 0.5ml not
With the Chinese herbal medicine of the present invention of concentration, mixing is placed in 37 DEG C of cultures and is incubated 4 hours, and removal, which is placed in cryostat, terminates reaction.
It counts tumor cell number living and calculates inhibiting rate.Chinese herbal medicine of the present invention used in the present embodiment is consistent with embodiment 5.It the results are shown in Table
Shown in 5.
Influence of the table 5 to mouse H22 liver cancer cells growth in vitro
The result shows that the Chinese herbal medicine in the present invention has significant inhibiting effect to H22 liver cancer cells, with drug concentration
Increase inhibiting effect enhancing.
2nd, to the influence of mouse Chinese mugwort formula ascites carcinoma (EAC) cell in-vitro growth
7 days after being inoculated with Chinese mugwort formula ascites carcinoma (EAC) cell is taken, centrifugation discards supernatant liquid, washed with RPMI1640 culture solutions
It is secondary, then it is prepared into 1*107The cell suspension of R/L, with RPMI1640 culture solutions of the pH6.8 containing 10% calf serum by medicine
Object is diluted to required various concentration, sets up ten parallel pipes, and often pipe adds in 0.5ml cell suspensions, is then respectively adding
The Chinese herbal medicine of the present invention of 0.5ml various concentrations, mixing are placed in 37 DEG C of cultures and are incubated 4 hours, and removal is placed in cryostat eventually
Only react.It counts tumor cell number living and calculates inhibiting rate.Chinese herbal medicine of the present invention used in the present embodiment is consistent with embodiment 5,
It the results are shown in Table shown in 6.
Influence of the table 6 to mouse Chinese mugwort formula ascites carcinoma (EAC) cell in-vitro growth
The result shows that the Chinese herbal medicine in the present invention has significant inhibiting effect to Chinese mugwort formula ascites carcinoma (EAC) cell, with
The increase inhibiting effect enhancing of drug concentration.
In summary, during Chinese herbal medicine of the invention is tested in vitro, dosage 1.88~15.00mg/ml ranges are to Mouse Liver
Cancer cell and Chinese mugwort formula ascites carcinoma (EAC) cell in-vitro are acted on dose-dependent inhibition.
The foregoing is merely the preferred embodiment of the present invention, are not intended to restrict the invention, for those skilled in the art
For, the present invention can have various modifications and changes.All any modifications made within spirit and principles of the present invention are equal
Replace, improve etc., it should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of preparation method of the Chinese herbal medicine of effective inhibition tumour, it is characterised in that：The method is as follows：
Step 1: weighing each ingredient of Chinese herbal medicine in proportion, the ingredient of Chinese herbal medicine and the parts by weight of various composition are：It is yellow
20~30 parts of stilbene, 15~25 parts of Radix Notoginseng, 10~20 parts impetuous, 10~15 parts of tulip bulb, 10~20 parts of Rhizoma Chuanxiong, oyster 5~10
Part, 10~15 parts of earthworm, 1~3 part of Radix Codonopsis, 10~15 parts of Paris polyphylla, 1~3 part of purslane, 1~3 part of black nightshade, 20~30 parts of rheum officinale,
10~100 parts of 0.2~1 part of borneol, 5~10 parts of perilla seed, 1~3 part of stiff silkworm, 0.5~3 part of Reishi sporule and water, and will be various
The ingredient of Chinese herbal medicine is ground into the powder that grain size is less than 2mm respectively；
It is impetuous：Refined honey is added in the impetuous powder of formula ratio and is mixed thoroughly, and place it in pot, is not glued with being fried with slow fire
Hand takes out, natural cooling；The seed of garden balsam and the mass ratio of refined honey are：1：(2~3)；Radix Astragali：In Milkvetch Root plus white wine is mixed thoroughly,
And place it in pot, it with when being fried with slow fire wine dry doubling and having detonans, takes out, natural cooling, the mass ratio of Radix Astragali and white wine is：1：
(15~20)；
20~30 points are stirred at 90~100 DEG C Step 2: the Reishi sporule of formula ratio and oyster are added in the water of formula ratio
Then clock adds in Radix Astragali, Radix Notoginseng, the seed of garden balsam, Rhizoma Chuanxiong and the tulip bulb of formula ratio, continue to be stirred to react 3 at 90~100 DEG C~
5h obtains semi-finished product；
Continue at 90~100 DEG C in obtained semi-finished product Step 3: the stiff silkworm of formula ratio and borneol are added in step 2
Be stirred to react 20~30 minutes, in the whipping process, be slowly added to the perilla seed of formula ratio, earthworm, Radix Codonopsis, Paris polyphylla, purslane,
Black nightshade and Rhubarb continue stirring 10~20 minutes after adding, filtering, obtain to inhibit the Chinese herbal medicine of tumour.
2. the preparation method of the Chinese herbal medicine of effective inhibition tumour according to claim 1, it is characterised in that：The Chinese herbal medicine
2~5 parts of Sculellaria barbata is further included, then when containing Sculellaria barbata in Chinese herbal medicine, by the Sculellaria barbata powder of formula ratio in step 3
After being mixed with perilla seed, earthworm, Radix Codonopsis, Paris polyphylla, purslane, black nightshade and Rhubarb, it is slowly added to.
3. the preparation method of the Chinese herbal medicine of effective inhibition tumour according to claim 1 or 2, it is characterised in that：In described
Herbal medicine further includes 4~9 parts of Sculellaria barbata, then when containing the fruit of glossy privet in the Chinese herbal medicine, the fruit of glossy privet powder of formula ratio is existed
It is sprinkled into system, is then stirred to react at 90~100 DEG C 20~30 minutes in step 3, add perilla seed, earthworm, party
Ginseng, Paris polyphylla, purslane, black nightshade and Rhubarb.
4. a kind of effective Chinese herbal medicine for inhibiting tumour, it is characterised in that：The ingredient of the Chinese herbal medicine and the weight of various composition
Number is：20~30 parts of Radix Astragali, 15~25 parts of Radix Notoginseng, 10~20 parts impetuous, 10~15 parts of tulip bulb, 10~20 parts of Rhizoma Chuanxiong,
5~10 parts of oyster, 10~15 parts of earthworm, 1~3 part of Radix Codonopsis, 10~15 parts of Paris polyphylla, 1~3 part of purslane, 1~3 part of black nightshade, rheum officinale
0.5~3 part of 20~30 parts, 0.2~1 part of borneol, 5~10 parts of perilla seed, 1~3 part of stiff silkworm and Reishi sporule.
5. effective Chinese herbal medicine for inhibiting tumour according to claim 4, it is characterised in that：The ingredient of the Chinese herbal medicine and
The parts by weight of various composition are：23~27 parts of Radix Astragali, 18~22 parts of Radix Notoginseng, 14~16 parts impetuous, 12~13 parts of tulip bulb,
13~17 parts of Rhizoma Chuanxiong, 6~8 parts of oyster, 13~14 parts of earthworm, 2 parts of Radix Codonopsis, 12~14 parts of Paris polyphylla, 2 parts of purslane, 2 parts of black nightshade,
1~2 part of 23~27 parts of rheum officinale, 0.4~0.6 part of borneol, 6~7 parts of perilla seed, 2 parts of stiff silkworm and Reishi sporule.
6. effective Chinese herbal medicine for inhibiting tumour according to claim 4 or 5, it is characterised in that：The ingredient of the Chinese herbal medicine
Sculellaria barbata is further included, and the parts by weight of Sculellaria barbata are 2~5 parts.
7. effective Chinese herbal medicine for inhibiting tumour according to claim 6, it is characterised in that：The parts by weight of the Sculellaria barbata
It is 3~4 parts.
8. effective Chinese herbal medicine for inhibiting tumour according to claim 7, it is characterised in that：The ingredient of the Chinese herbal medicine also wraps
Ternateleaf rabdosia herb is included, and the parts by weight of ternateleaf rabdosia herb are 0.5~2 part, preferably 1 part.
9. effective Chinese herbal medicine for inhibiting tumour described according to claim 6 or 7, it is characterised in that：The ingredient of the Chinese herbal medicine
The fruit of glossy privet is further included, and the parts by weight of the fruit of glossy privet are 4~9 parts.
10. effective Chinese herbal medicine for inhibiting tumour according to claim 9, it is characterised in that：The parts by weight of the fruit of glossy privet are 6
~7 parts.
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| TWI846105B (en) * | 2022-10-21 | 2024-06-21 | 吳景崇 | Chinese medicine composition for treating pulmonary adenocarcinoma and preparation method thereof |
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