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CN108210393A - A kind of anti-bacteria wet keeping de-cutin shower dew and preparation method thereof - Google Patents

A kind of anti-bacteria wet keeping de-cutin shower dew and preparation method thereof Download PDF

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Publication number
CN108210393A
CN108210393A CN201810273409.9A CN201810273409A CN108210393A CN 108210393 A CN108210393 A CN 108210393A CN 201810273409 A CN201810273409 A CN 201810273409A CN 108210393 A CN108210393 A CN 108210393A
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wet keeping
bacteria wet
acid
cutin
cutin shower
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李皆延
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/347Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39Derivatives containing from 2 to 10 oxyalkylene groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Public Health (AREA)
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  • Birds (AREA)
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  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a kind of anti-bacteria wet keeping de-cutin shower dew and preparation method thereof, it includes Thymol, the double poplar acid of water, ethyl alcohol, propylene glycol, acetate, myristic acid, palmitic acid, potassium hydroxide, glycol distearate, sulfosuccinic acid ethylhexyl sodium, Cocoamidopropyl betaine, sodium cocoyl glycinate, polyquaternium 7, polyglyceryl fatty acid ester composition, tetrasodium ethylenediamine tetraacetate, sodium chloride, low-carbon alcohols, ginseng extract, preservative, water, squalene, gaultherolin and tea oil extract, anti-bacteria wet keeping de-cutin shower of the present invention reveals mild pro-skin, it can effective anti-bacteria wet keeping, particularly suitable for there is the crowd of skin itching and body moss use.

Description

A kind of anti-bacteria wet keeping de-cutin shower dew and preparation method thereof
Technical field
The invention belongs to anti-bacteria wet keeping de-cutin shower dew articles for use fields, and in particular to a kind of anti-bacteria wet keeping de-cutin shower Dew and preparation method thereof.
Background technology
Shower cream is also known as bath oil, refers to a kind of liquid ceanser used when having a bath, is that a kind of modern is common Cleaning supplies, the invention of bath oil is primarily to the sense of touch and effect of substitution tradition cleaning soap.
Shower cream does not have very hard feeling as soap, the effect of amino acid bath foam when contacting people's skin Especially apparent, amino acid anti-bacteria wet keeping de-cutin shower is showed one's true colours to chamfer compared with anti-bacteria wet keeping of the Sulfates surfactant for raw material Matter shower cream pH value is more relatively low, mild moisturizing, strong acid-base will not be caused to stimulate skin.
The antibacterial effect of traditional anti-bacteria wet keeping de-cutin shower dew is to be improved, particularly to staphylococcus aureus Resistance it is insufficient, while also there is a situation where that moistening effect is bad, traditional anti-bacteria wet keeping de-cutin shower dew is especially in the presence of The problem of whitening exfoliating scarce capacity, how to improve the anti-bacteria wet keeping effect of anti-bacteria wet keeping de-cutin shower dew makes its stingless again Swash property and the technological difficulties of this field can be become with whitening exfoliating.
Invention content
The purpose of the present invention is to provide a kind of anti-bacteria wet keeping de-cutin shower dew, can effective anti-bacteria wet keeping, it is especially suitable It is used together in there is the crowd of skin itching and body moss.
The present invention is by the following technical programs to realize above-mentioned purpose, and a kind of anti-bacteria wet keeping de-cutin shower reveals, including The component of following weight percent meter:Thymol 0.1 ~ 0.5%, ethyl alcohol 0.2 ~ 1%, propylene glycol 0.5 ~ 3.5%, acetate 2 ~ 8%, Myristic acid 4 ~ 9%, palmitic acid 2 ~ 8%, potassium hydroxide 1.5 ~ 6%, glycol distearate 1 ~ 2%, sulfosuccinic acid diethyl It is own ester sodium 1 ~ 5%, Cocoamidopropyl betaine 3 ~ 7%, sodium cocoyl glycinate 1 ~ 5%, polyquaternium -7 0.1 ~ 1.5%, poly- sweet Oil and fat acid ester composite 0.3 ~ 3%, tetrasodium ethylenediamine tetraacetate 0.1 ~ 1%, sodium chloride 0.2 ~ 1.5%, ginseng extract 0.2 ~ 1%th, water 30 ~ 80%, salicyl salicylate (salsalate) 0.1 ~ 0.5%, low-carbon alcohols 0.1 ~ 1%, squalene 0.1 ~ 1%, gaultherolin 0.3 ~ 1%, tea oil Extract 0.1 ~ 1% and preservative 0.1 ~ 0.3%.
Preferably, the preservative is Phenoxyethanol.
Preferably, the polyglyceryl fatty acid ester composition includes -4 certain herbaceous plants with big flowers acid esters of -6 caprylate of polyglycereol and polyglycereol.
Preferably, the anti-bacteria wet keeping de-cutin shower dew further includes plant extracts 0.2 ~ 2.0%.
A kind of method for preparing anti-bacteria wet keeping de-cutin shower dew, includes the following steps:
(1)Thymol, salicyl salicylate (salsalate) are added in be dissolved to transparent in ethyl alcohol, add plant extracts, propylene glycol stir to It is fully transparent, bactericidal composition is prepared into, it is spare;
(2)Potassium hydroxide is added in into the water of component weight 45 ~ 55% to dissolve and stir evenly, and then adds in acetate, Pork and beans Cool acid, palmitic acid ethylene glycol distearyl acid, sulfosuccinic acid ethylhexyl sodium, are persistently stirred and heated to 75 DEG C, insulation reaction 25~35min;
(3)After the completion of reaction, Cocoamidopropyl betaine, polyglyceryl fatty acid ester composition are added in, and stir evenly, system 55 DEG C are cooled to, adds in sodium cocoyl glycinate, polyquaternium -7, and stir evenly;
(4)System is cooled to 35 DEG C, and tetrasodium ethylenediamine tetraacetate, sodium chloride, low-carbon alcohols, ginseng extraction are then added in into system Object, stirring is to being completely dissolved;
(5)Enter step(1)Bactericidal composition, stir evenly, be eventually adding preservative, water, squalene, gaultherolin and tea Oily extract, stirs evenly.
Plant extracts of the present invention contains 55% camellia flower extract, 25% Honegsukle flower P.E and 20% Camphorated oil has good antibacterial and bacteriostasis.Anti-bacteria wet keeping de-cutin shower dew of the present invention is particularly suitable for there is skin itching And the crowd of body moss uses.
The composition of low-carbon alcohols, gaultherolin and tea oil extract protrudes the effect of whitening exfoliating.
Advantageous effect:Anti-bacteria wet keeping de-cutin shower dew antibacterial effect of the present invention is strong, the killing to staphylococcus aureus Rate is up to 99.9%;Anti-bacteria wet keeping de-cutin shower dew moisture-keeping efficacy of the present invention is remarkable;Anti-bacteria wet keeping de-cutin shower dew of the present invention is anti- Bacterium moistening effect is good, while present invention shower is nonirritant, particularly can be with whitening exfoliating.
Specific embodiment
The present invention is further described, but the present invention is not limited only to following embodiment below by way of specific embodiment. It in the scope of the present invention or is not departing from present disclosure, in spirit and scope, anti-bacteria wet keeping of the present invention is being gone Cutin shower cream and preparation method thereof is suitably modified, replaces the identical component of effect, to those skilled in the art It is it will be apparent that they are considered as being included within the scope of the present invention.
Embodiment 1:
A kind of anti-bacteria wet keeping de-cutin shower dew includes the component of following weight percent meter:Thymol 0.25%, ethyl alcohol 0.6%th, propylene glycol 2%, acetate 5%, myristic acid 7%, palmitic acid 5%, potassium hydroxide 3.5%, glycol distearate 1.5%, Sulfosuccinic acid ethylhexyl sodium 3%, Cocoamidopropyl betaine 5%, sodium cocoyl glycinate 3%, polyquaternium -7 0.8%th, polyglyceryl fatty acid ester composition 1.7%, tetrasodium ethylenediamine tetraacetate 0.5%, sodium chloride 0.8%, ginseng extract 0.6%, Water 65%, 0.55 squalene 0.6 of sour 0.25 low-carbon alcohols, 0.19% institute of 0.6% tea oil extract 0.5 of gaultherolin and preservative Preservative is stated as Phenoxyethanol;The polyglyceryl fatty acid ester composition includes -4 certain herbaceous plants with big flowers of -6 caprylate of polyglycereol and polyglycereol;Institute It states anti-bacteria wet keeping de-cutin shower dew and further includes plant extracts 1%.
A kind of method for preparing anti-bacteria wet keeping de-cutin shower dew, includes the following steps:
(1)Thymol, salicyl salicylate (salsalate) are added in be dissolved to transparent in ethyl alcohol, add plant extracts, propylene glycol stir to It is fully transparent, bactericidal composition is prepared into, it is spare;
(2)Potassium hydroxide is added in into the water of component weight 45 ~ 55% to dissolve and stir evenly, and then adds in acetate, Pork and beans Cool acid, palmitic acid ethylene glycol distearyl acid, sulfosuccinic acid ethylhexyl sodium, are persistently stirred and heated to 75 DEG C, insulation reaction 25~35min;
(3)After the completion of reaction, Cocoamidopropyl betaine, polyglyceryl fatty acid ester composition are added in, and stir evenly, system 55 DEG C are cooled to, adds in sodium cocoyl glycinate, polyquaternium -7, and stir evenly;
(4)System is cooled to 35 DEG C, and tetrasodium ethylenediamine tetraacetate, sodium chloride, low-carbon alcohols, ginseng extraction are then added in into system Object, stirring is to being completely dissolved;
(5)Enter step(1)Bactericidal composition, stir evenly, be eventually adding preservative, water, squalene, gaultherolin and tea Oily extract, stirs evenly.
Embodiment 2:
A kind of anti-bacteria wet keeping de-cutin shower dew includes the component of following weight percent meter:Thymol 0.1%, ethyl alcohol 0.2%th, propylene glycol 0.5%, acetate 2%, myristic acid 4%, palmitic acid 2%, potassium hydroxide 1.5%, glycol distearate 1%, Sulfosuccinic acid ethylhexyl sodium 1%, Cocoamidopropyl betaine 3%, sodium cocoyl glycinate 1%, polyquaternium -7 0.1%th, polyglyceryl fatty acid ester composition 0.3%, tetrasodium ethylenediamine tetraacetate 0.1%, sodium chloride 0.2%, ginseng extract 0.2%, Water 30%, salicyl salicylate (salsalate) 0.1%, low-carbon alcohols 0.1%, squalene 0.1%, gaultherolin 0.3%, tea oil extract 0.1% and anti- Rotten agent 0.1%;The preservative is Phenoxyethanol;The polyglyceryl fatty acid ester composition includes -6 caprylate of polyglycereol and gathers - 4 certain herbaceous plants with big flowers acid esters of glycerine;The anti-bacteria wet keeping de-cutin shower dew further includes plant extracts 0.2%.
The method of anti-bacteria wet keeping de-cutin shower dew is prepared with embodiment 1.
Embodiment 3:
A kind of anti-bacteria wet keeping de-cutin shower dew includes the component of following weight percent meter:Thymol 0.5%, ethyl alcohol 1%, Propylene glycol 3.5%, acetate 8%, myristic acid 9%, palmitic acid 8%, potassium hydroxide 6%, glycol distearate 2%, sulfo group amber It is amber acid ethylhexyl sodium 5%, Cocoamidopropyl betaine 7%, sodium cocoyl glycinate 5%, polyquaternium -7 1.5%, poly- sweet Oil and fat acid ester composite 3%, tetrasodium ethylenediamine tetraacetate 1%, sodium chloride 1.5%, ginseng extract 1%, water 80%, salicyl salicylate (salsalate) 0.5%th, low-carbon alcohols 1%, squalene 1%, gaultherolin 1%, tea oil extract 1% and preservative 0.3%;The preservative is benzene Oxyethanol;The polyglyceryl fatty acid ester composition includes -4 certain herbaceous plants with big flowers acid esters of -6 caprylate of polyglycereol and polyglycereol;The antibacterial is protected Wet de-cutin shower dew further includes plant extracts 2.0%.
The method of anti-bacteria wet keeping de-cutin shower dew is prepared with embodiment 1.
Comparative example 1:
Plant extracts is become 0 from 15g, Thymol is from 2.5g becomes 10g, salicyl salicylate (salsalate) becomes 10g from 2.5g, other groups Divide and prepare with embodiment 1.
Comparative example 2:
Thymol is become into 0, salicyl salicylate (salsalate) from 2.5g and becomes 0 from 2.5g, plant extracts becomes 20g, other components from 15g With preparation with embodiment 1.
Comparative example 3:
Polyglyceryl fatty acid ester composition is become 0 from 10g, squalene becomes 15g from 5g, other components and prepares same embodiment 1。
Comparative example 4:
Squalene is become into 0g from 5g, polyglyceryl fatty acid ester composition becomes 15 from 10g, other components and prepares same embodiment 1。
Test example one:
The anti-microbial property test of anti-bacteria wet keeping de-cutin shower dew of the present invention
According to GB19877.2-2005《Extraordinary bath agent》Antibacterial prepared by the embodiment of the present invention 1 ~ 3 and comparative example 1 ~ 2 is measured to protect The antibacterial effect of wet de-cutin shower dew, result such as the following table 1:
The antibacterial effect of 1 anti-bacteria wet keeping de-cutin shower of the present invention of table dew
It can be obtained by upper table 1, the good anti-bacterial effect of 1 ~ 3 anti-bacteria wet keeping de-cutin shower of embodiment of the present invention dew, to golden yellow grape The killing rate of coccus reaches up to 99.85%《Extraordinary bath agent》The requirement of antibiotic rate >=90% in standard, therefore antibacterial of the present invention is protected Wet de-cutin shower dew reaches the sterilizing rate highest of the rank, wherein embodiment 1 of antibacterial antiplaque moisturizing de-cutin shower dew, explanation 1 each component of embodiment and proportioning synergistic effect are most strong.Plant extracts is free of in 1 anti-bacteria wet keeping de-cutin shower of comparative example dew, 2 anti-bacteria wet keeping de-cutin shower of comparative example dew only contains plant extracts, and sterilizing rate will be low compared to embodiment 1 ~ 3, Illustrate that plant extracts of the present invention has very strong synergistic effect with Thymol and salicyl salicylate (salsalate), three's compounding can rise very strong Antibacterial action.
Test example two:
The irritation test of anti-bacteria wet keeping de-cutin shower dew of the present invention
According to《Cosmetics health specification》(Version in 2007)Skin irritation/corrosion test is to embodiment 1 and comparative example 3 ~ 4 Anti-bacteria wet keeping de-cutin shower dew carries out dermoreaction scoring, and concrete operations are as follows:
1st, experimental animal:Healthy white rabbit 12, female, 1.8 ~ 2.2kg, skin zero damage are divided into 3 groups, every group 4.
2nd, experimental procedure:
Experiment white rabbit back backbone diamond wool is cut for 24 hours before 2.1 experiments, do not damage epidermis, unhairing range or so be respectively 3cm × 3cm。
2.2 take tested material(That is embodiment 1 and 3 ~ 4 anti-bacteria wet keeping de-cutin shower of comparative example dew)0.5g is coated directly on skin On, then with two layers of gauze(2.5cm×2.5cm)It is covered with one layer of glassine paper, then consolidated with nonirritant adhesive plaster and bandage It is fixed.Opposite side skin is as control.Using blocking test, application 2h.After the test residual tested material is removed with warm water.
Position dermoreaction is smeared in 2.3 1,24, the 48 and 72h observations after tested material is removed, and it is anti-to carry out skin by table 2 Should score, overall merit is carried out with the average value of animal subject integration, according to for 24 hours, 48h and 72h respectively observe time point top Mean value judges skin irritatin intensity by table 3.
2 skin wound repair of table scores
Dermoreaction Integration
Erythema and eschar are formed
Without erythema 0
Slight erythema(It is visible reluctantly) 2
Apparent erythema 1
Moderate ~ severe erythema 2
Severe erythema(Aubergine)It is formed to slight eschar 3
Oedema is formed
Without oedema 0
Slight oedema(It is visible reluctantly) 1
Mild edema(Cutaneous protuberance is clearly outlined) 1
Intermediate edema(Cutaneous protuberance 1mm) 2
Severe edema(Cutaneous protuberance is more than 1mm, and range expands) 3
Top 8
3 skin irritatin strength grading of table
Integral mean value Intensity
0~<0.5 It is nonirritant
0.5~<2.0 Subexcite
2.0~<6.0 Moderate stimulation
6.0~8.0 Strong and stimulating
3rd, experimental result:It see the table below 4
The irritation test result of 4 anti-bacteria wet keeping de-cutin shower of the present invention of table dew
It can be obtained by upper table 4, anti-bacteria wet keeping de-cutin shower of the present invention reveals to no skin irritation, however poly- sweet when lacking in system When oily -6 caprylates, -4 certain herbaceous plants with big flowers acid esters of polyglycereol and -3 cocounut oil acid esters of polyglycereol(That is comparative example 3), anti-bacteria wet keeping de-cutin shower dew Irritation enhancing, to skin generate moderate stimulation, cause erythema and oedema;And when lacking squalene in system(I.e. Comparative example 4), anti-bacteria wet keeping de-cutin shower dew irritation also have slight enhancing, illustrate -6 caprylate of polyglycereol, polyglycereol -4 Certain herbaceous plants with big flowers acid esters and the polyglyceryl fatty acid ester composition of -3 cocounut oil acid esters of polyglycereol compounding are indispensable in the technical solution of the present invention, Three's ingredient cooperates with, and can be substantially reduced formula irritation, then coordinate squalene, further reduces stimulation of the system to skin Property.
Test example three:
The moistening effect test of anti-bacteria wet keeping de-cutin shower dew of the present invention
1st, trial target:Anti-bacteria wet keeping de-cutin shower dew prepared by the embodiment of the present invention 1 ~ 3 and comparative example 3.
2nd, tested crowd
Number:32 people
Age:Between 24 ~ 30 years old
Gender:20 people of female, male 12 people
Grouping:It is divided into 4 groups, every group of 5 people of female, male 3 people.
Health status:Subjects skin's health, no skin disease allergies meet subject and volunteer inclusion criteria.
3rd, test method:In 5 square centimeters of position of volunteer's right hand inner forearm, test zone is drawn, is surveyed with moisture Examination instrument test respectively washing before skin water content and washing 2 hours after moisture content of skin, it is increased to calculate water content Percentage %.
4th, test result:It see the table below 5.
The moistening effect test result of 5 anti-bacteria wet keeping de-cutin shower of the present invention of table dew
Project Moisture content of skin before washing Moisture content of skin after washing 2 hours Water content increases percentage %
Embodiment 1 35.24 43.91 24.64
Embodiment 2 36.88 45.51 23.52
Embodiment 3 35.80 44.12 23.14
Comparative example 3 35.57 40.22 13.14
It can be obtained by upper table 5, the moistening effect of anti-bacteria wet keeping de-cutin shower dew of the present invention is good, moisture content of skin after washing 2 hours Increase percentage more than 23%, it is especially best with the moistening effect of embodiment 1, reach 24.6%, each component synergistic effect is most strong;Together When embodiment 1 ~ 3 compared with comparative example 3, water content increases percentage and improves about 10%, illustrates -6 octanoic acid of polyglycereol of the present invention The polyglyceryl fatty acid ester composition of ester, -4 certain herbaceous plants with big flowers acid esters of polyglycereol and -3 cocounut oil acid esters of polyglycereol compounding can not only reduce system Irritation, moreover it is possible to effectively improve the performance of keeping humidity of system, alleviate skin tight feeling after taking a shower.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair The limitation of the present invention, protection scope of the present invention should be subject to claim limited range.For the art For those of ordinary skill, without departing from the spirit and scope of the present invention, several improvements and modifications can also be made, these change Protection scope of the present invention is also should be regarded as into retouching.

Claims (5)

1. a kind of anti-bacteria wet keeping de-cutin shower dew includes the component of following weight percent meter:Thymol 0.1 ~ 0.5%, second Alcohol 0.2 ~ 1%, acetate 2 ~ 8%, myristic acid 4 ~ 9%, palmitic acid 2 ~ 8%, potassium hydroxide 1.5 ~ 6%, gathers at propylene glycol 0.5 ~ 3.5% Quaternary ammonium salt -7 0.1 ~ 1.5%, polyglyceryl fatty acid ester composition 0.3 ~ 3%, tetrasodium ethylenediamine tetraacetate 0.1 ~ 1%, sodium chloride 0.2 ~ 1.5%, ginseng extract 0.2 ~ 1%, water 30 ~ 80%, which is characterized in that further include salicyl salicylate (salsalate) 0.1 ~ 0.5%, low-carbon alcohols 0.1 ~ 1%th, squalene 0.1 ~ 1%, gaultherolin 0.3 ~ 1%, 0.1 ~ 1% glycol distearate 1 ~ 2% of tea oil extract, sulfo group Succinic acid ethylhexyl sodium 1 ~ 5%, Cocoamidopropyl betaine 3 ~ 7%, sodium cocoyl glycinate 1 ~ 5% and preservative 0.1 ~ 0.3%。
2. anti-bacteria wet keeping de-cutin shower dew as described in claim 1, which is characterized in that the preservative is Phenoxyethanol.
3. anti-bacteria wet keeping de-cutin shower dew as described in claim 1, which is characterized in that the polyglyceryl fatty acid ester combination Object includes -4 certain herbaceous plants with big flowers acid esters of -6 caprylate of polyglycereol and polyglycereol.
4. anti-bacteria wet keeping de-cutin shower dew as described in claim 1, which is characterized in that the anti-bacteria wet keeping de-cutin shower Dew further includes plant extracts 0.2 ~ 2.0%.
A kind of 5. method of anti-bacteria wet keeping de-cutin shower dew prepared as described in claim 1 ~ 4 is any, which is characterized in that packet Include following steps:
(1)Thymol, salicyl salicylate (salsalate) are added in be dissolved to transparent in ethyl alcohol, add plant extracts, propylene glycol stir to It is fully transparent, bactericidal composition is prepared into, it is spare;
(2)Potassium hydroxide is added in into the water of component weight 45 ~ 55% to dissolve and stir evenly, and then adds in acetate, Pork and beans Cool acid, palmitic acid ethylene glycol distearyl acid, sulfosuccinic acid ethylhexyl sodium, are persistently stirred and heated to 75 DEG C, insulation reaction 25~35min;
(3)After the completion of reaction, Cocoamidopropyl betaine, polyglyceryl fatty acid ester composition are added in, and stir evenly, system 55 DEG C are cooled to, adds in sodium cocoyl glycinate, polyquaternium -7, and stir evenly;
(4)System is cooled to 35 DEG C, and tetrasodium ethylenediamine tetraacetate, sodium chloride, low-carbon alcohols, ginseng extraction are then added in into system Object, stirring is to being completely dissolved;
(5)Enter step(1)Bactericidal composition, stir evenly, be eventually adding preservative, water, squalene, gaultherolin and tea Oily extract, stirs evenly.
CN201810273409.9A 2018-03-29 2018-03-29 A kind of anti-bacteria wet keeping de-cutin shower dew and preparation method thereof Withdrawn CN108210393A (en)

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CN108294990A (en) * 2018-03-29 2018-07-20 李皆延 Shower cream and preparation method thereof
CN112515989A (en) * 2019-09-17 2021-03-19 上海利康消毒高科技有限公司 Compound low-alcohol disinfectant and preparation method thereof
WO2021214215A1 (en) * 2020-04-23 2021-10-28 Arch Uk Biocides Ltd Synergistic biocide composition with a polyglycerol ester
WO2022269481A1 (en) * 2021-06-21 2022-12-29 Evergreen Land Limited Topical antimicrobial formulation

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CN104771345A (en) * 2015-03-19 2015-07-15 苏州谷力生物科技有限公司 Bath lotion and preparation method thereof
CN104800123A (en) * 2015-04-28 2015-07-29 威莱(广州)日用品有限公司 Antibacterial soap-based shower gel and preparation method thereof

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CN1135174A (en) * 1993-06-18 1996-11-06 普罗克特和甘保尔公司 Personal cleansing system comprising a polymeric diamond-mesh bath sponge and a liquid cleanser with moisturizer
CN104771345A (en) * 2015-03-19 2015-07-15 苏州谷力生物科技有限公司 Bath lotion and preparation method thereof
CN104800123A (en) * 2015-04-28 2015-07-29 威莱(广州)日用品有限公司 Antibacterial soap-based shower gel and preparation method thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108294990A (en) * 2018-03-29 2018-07-20 李皆延 Shower cream and preparation method thereof
CN112515989A (en) * 2019-09-17 2021-03-19 上海利康消毒高科技有限公司 Compound low-alcohol disinfectant and preparation method thereof
CN112515989B (en) * 2019-09-17 2023-06-02 上海利康消毒高科技有限公司 Compound low-alcohol disinfectant and preparation method thereof
WO2021214215A1 (en) * 2020-04-23 2021-10-28 Arch Uk Biocides Ltd Synergistic biocide composition with a polyglycerol ester
WO2022269481A1 (en) * 2021-06-21 2022-12-29 Evergreen Land Limited Topical antimicrobial formulation

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