CN108126236B

CN108126236B - Medicine coating material and preparation method thereof

Info

Publication number: CN108126236B
Application number: CN201711384801.2A
Authority: CN
Inventors: 黄娟; 王建伟; 陆涛
Original assignee: Jinhua Jingdi Medical Supplies Co ltd; Zhejiang Lover Health Science and Technology Development Co Ltd
Current assignee: Jinhua Jingdi Medical Supplies Co ltd; Zhejiang Lover Health Science and Technology Development Co Ltd
Priority date: 2017-12-20
Filing date: 2017-12-20
Publication date: 2021-01-01
Anticipated expiration: 2037-12-20
Also published as: CN108126236A

Abstract

The invention relates to a medical coating material and a preparation method thereof in the field of medical health. Dissolving 5-30 parts by mass of sodium alginate, 3-20 parts by mass of water-soluble chitosan, 5-50 parts by mass of sodium chloride, 20-100 parts by mass of glycerol and 0-100 parts by mass of propylene glycol in 100-1000 parts by mass of distilled water under stirring to obtain A; adding 50-600 parts by mass of emulsifier and 300-700 parts by mass of siloxane resin into 300-800 parts by mass of volatile siloxane, and uniformly mixing to obtain B; slowly adding the A into the B solution, and emulsifying uniformly to obtain the medicinal coating material. The medical coating material of the invention has the functions of stopping bleeding and accelerating the healing of skin wound; has antibacterial and antibacterial effects, and has strong antibacterial and antibacterial effects on wound surface and external bacteria; can actively and passively moisturize the skin, has hydration effect on scar skin and has good repairing effect.

Description

Medicine coating material and preparation method thereof

Technical Field

The invention relates to a medical coating material and a preparation method thereof, belonging to a medical biomaterial in the field of medical health.

Background

At present, the body surface wound, the operation incision and the burned and scalded surface of a human body are generally treated by taking measures of coating and disinfecting gauze, winding a bandage and the like, the gauze is often attached to the wound surface due to blood coagulation, the granulation of the wound is repeatedly damaged when medicines are replaced, the wound healing time is prolonged, the patient can be suffered from pain which is difficult to bear sometimes, and the operation of medical care personnel is troublesome. And the traditional gauze dressing material has the defects of poor air permeability at the wound, difficult large-area use and easy invasion of bacteria.

Alginate is a natural anionic polysaccharide, can form gel after contacting with wound exudate, generates high absorption force by forming strong hydrophilic gel, can lock a large amount of water, and is a good gelling material. Meanwhile, the alginate is used for the metabolism of human bodyHas unique regulating effect, and has effects of relieving inflammation, stopping bleeding, and resolving hard mass. Chitosan is the only natural basic polysaccharide discovered so far, not only has antibacterial and hemostatic functions, but also can prevent the formation of fibrin, the proliferation of connective tissue cells and the synthesis of collagen, thereby minimizing the stagnation after the wound is healed. At C2-NH of chitosan₂The water-soluble chitosan is obtained by deriving and introducing acid radical ions, carboxymethyl and quaternary ammonium salt on C6-OH or degrading chitosan into chitosan oligosaccharide, improving deacetylation degree and the like, and the effective-NH of the chitosan is improved₃ ⁺The exposure and the permeability of chitosan to cells, and the antibacterial and bacteriostatic activity of the chitosan are also obviously increased.

The chitosan/alginate dressing consisting of water-soluble chitosan and alginate can rapidly absorb exudate and blood after contacting with the exudate and the blood, and forms adhesive gel on the contact surface to be attached to the wound surface. However, the chitosan/alginate dressing has the fatal defects of poor water resistance, strong hygroscopicity, high air permeability and the like because the molecular structure of the chitosan/alginate dressing contains a large number of hydrophilic groups such as hydroxyl groups and the like.

Disclosure of Invention

Aiming at the problems in the prior art, the invention aims to improve the water resistance and the oxygen permeability of the chitosan/sodium alginate dressing by introducing siloxane with the water resistance, high oxygen permeability and scar removing effect. The invention mixes and dissolves sodium alginate and water-soluble chitosan in distilled water at a ratio of 10: 1-1.5: 1, and emulsifies the mixture with siloxane resin, surfactant and volatile siloxane, thereby developing a safe, effective and sprayable quick-acting curing biological liquid adhesive bandage. Alginate can absorb wound exudate; the chitosan can inhibit the adhesion of bacteria and the proliferation of pathogenic microorganisms on the composite dressing, and can reduce the risk of bacterial infection even if the composite dressing is used for a long time; the siloxane resin is breathable and waterproof, and can reduce the water diffusion of the wound and repair scars by sealing and hydrating the skin. The volatile siloxane is volatilized rapidly, and quick-acting curing of the dressing is realized.

The invention discloses a medicine coating material, which is prepared by the following method: dissolving 5-30 parts by mass of sodium alginate, 3-20 parts by mass of water-soluble chitosan, 5-50 parts by mass of sodium chloride, 20-100 parts by mass of glycerol and 0-100 parts by mass of propylene glycol in 100-1000 parts by mass of water under stirring to obtain A; adding 50-600 parts by mass of emulsifier and 300-700 parts by mass of siloxane resin into 300-800 parts by mass of volatile siloxane, and uniformly mixing to obtain B; slowly adding the A into the B solution, and emulsifying uniformly to obtain the medicinal coating material.

Preferably, the water-soluble chitosan is: hyaluronic acid-like chitosan, carboxymethyl chitosan, hydroxypropyl trimethyl ammonium chloride chitosan, chitosan lactate, chitosan hydrochloride, chitosan acetate or chitosan oligosaccharide.

Preferably, the emulsifier is: a water-in-oil emulsifier or a mixed emulsifier of a water-in-oil emulsifier and an oil-in-water emulsifier.

Preferably, the amount of the oil-in-water emulsifier is 1 to 100 parts by mass. The emulsifier is mainly water-in-oil emulsifier, such as span series, and small amount of oil-in-water emulsifier, such as tween series, can be added to adjust the emulsifying capacity of the mixed emulsifier.

Preferably, the silicone resin is trimethylsiloxysilicate, trimethylsiloxysilicate/polypropylsilsesquioxane, acrylate/trimethicone-methacrylate copolymer, trimethylsiloxysilicate/dimethiconol crosspolymer.

Preferably, the volatile silicone has a viscosity of 0.65mpa.s/25 ℃ and a flash point of less than-3 ℃.

Preferably, the emulsification mode is high-speed homogenizing emulsification, mechanical stirring emulsification or grinding emulsification.

The preparation method of the medical coating material comprises the following steps: dissolving 5-30 parts by mass of sodium alginate, 3-20 parts by mass of water-soluble chitosan, 5-50 parts by mass of sodium chloride, 20-100 parts by mass of glycerol and 0-100 parts by mass of propylene glycol in 100-1000 parts by mass of water under stirring to obtain A; adding 50-600 parts by mass of emulsifier and 300-700 parts by mass of siloxane resin into 300-800 parts by mass of volatile siloxane, and uniformly mixing to obtain B; slowly adding the A into the B solution, and emulsifying uniformly to obtain the medicinal coating material.

The emulsified solution is directly sprayed on the wound, and after the solvent is volatilized, a protective layer which can be breathable, waterproof, dustproof, free from the limitation of the shape and the area of the wound and free from the influence on the activity and the cleanness of a patient is formed on the surface of the wound. The product has elasticity and air permeability, is convenient to carry, does not affect the appearance when in use, does not cause uncomfortable feeling, can move freely, is safe and reliable to human body, and has excellent performances of rapidly sealing wound, resisting bacteria, stopping bleeding, promoting healing, removing scar, preventing water and the like. The product is not only suitable for various wounds, but also has special curative effect on certain wounds which are difficult to heal and are clinically troubled for a long time, is more easily accepted by consumers, and has huge market demand.

Detailed Description

The invention is further illustrated by the following specific examples:

example 1

Accurately weighing 20 parts of sodium alginate, 8 parts of chitosan oligosaccharide, 20 parts of sodium chloride and 40 parts of glycerol, and adding 852 parts of distilled water to prepare a light yellow liquid A; weighing 80200 parts of span and 400 parts of trimethylsiloxysilicate, adding 460 parts of hexamethyldisiloxane, stirring and dissolving to obtain B. Slowly adding the solution A into the solution B, homogenizing and emulsifying at high speed for 10min, bottling, and sealing. Directly coated on the surface of the wound, dried and solidified after 30 seconds and has smooth appearance.

Example 2

Accurately weighing 15 parts of sodium alginate, 10 parts of chitosan quaternary ammonium salt, 25 parts of sodium chloride and 20 parts of glycerol, and adding distilled water to 870 parts to prepare light yellow liquid A; weighing 120 parts of Emulsifier10(Dow corning) and 360 parts of acrylate/poly (trimethylsiloxane) -methacrylate copolymer, adding 580 parts of hexamethyldisiloxane, stirring and dissolving to obtain B. Slowly adding the solution A into the solution B, homogenizing and emulsifying at high speed for 10min, bottling, and sealing. Directly coated on the surface of the wound, dried and solidified after 30 seconds and has smooth appearance.

Example 3

Accurately weighing 20 parts of sodium alginate, 5 parts of hyaluronic acid-like chitosan, 20 parts of sodium chloride, 40 parts of glycerol and 20 parts of propylene glycol, and adding 1035 parts of distilled water to prepare light yellow liquid A; weighing 8050 parts of span, 8010 parts of tween and 300 parts of trimethylsiloxysilicate, adding 500 parts of hexamethyldisiloxane, stirring and dissolving to obtain B. Slowly adding the solution A into the solution B, homogenizing and emulsifying at high speed for 10min, bottling, and sealing. Directly coated on the surface of the wound, dried and solidified after 45 seconds, and has smooth appearance.

Example 4

Accurately weighing 10 parts of sodium alginate, 20 parts of chitosan oligosaccharide, 8 parts of sodium chloride, 40 parts of glycerol and 60 parts of propylene glycol, and adding distilled water to 220 parts to prepare light yellow liquid A; 482 parts of Emulsifier10(Dow burning) and 400 parts of trimethylsiloxysilicate are weighed, and 760 parts of hexamethyldisiloxane are added and stirred to dissolve the mixture to obtain B. Slowly adding the solution A into the solution B, homogenizing and emulsifying at high speed for 10min, bottling, and sealing. Spraying 15-20 cm away from the wound, drying and solidifying after 30 seconds, and having smooth appearance.

Example 5

Accurately weighing 5 parts of sodium alginate, 5 parts of carboxymethyl chitosan, 10 parts of sodium chloride, 40 parts of glycerol and 60 parts of propylene glycol, and adding distilled water to 240 parts to prepare light yellow liquid A; 450 parts of Emulsifier10(Dow burning) and 440 parts of trimethylsiloxysilicate/polypropylsilsesquioxane are weighed, 750 parts of hexamethyldisiloxane are added, and stirring and dissolving are carried out, thus obtaining B. Slowly adding the solution A into the solution B, homogenizing and emulsifying at high speed for 10min, bottling, and sealing. Spraying 15-20 cm away from the wound, drying and solidifying after 30 seconds, and having smooth appearance.

The coating material of the invention has good bacteriostatic effect, and the experimental result is as follows:

note: "+" indicates colonies growing and "-" indicates no colonies growing.

Finally, it should also be noted that the above list is only a specific implementation example of the present invention. It is obvious that the invention is not limited to the above embodiment examples, but that many variations are possible. All modifications which can be derived or suggested by a person skilled in the art from the disclosure of the present invention are to be considered within the scope of the invention.

Claims

1. A medical coating material characterized by being produced by the following method: dissolving 5-30 parts by mass of sodium alginate, 3-20 parts by mass of water-soluble chitosan, 5-50 parts by mass of sodium chloride, 20-100 parts by mass of glycerol and 0-100 parts by mass of propylene glycol in 100-1000 parts by mass of water under stirring to obtain A; adding 50-600 parts by mass of emulsifier and 300-700 parts by mass of siloxane resin into 300-800 parts by mass of volatile siloxane, and uniformly mixing to obtain B; slowly adding the A into the B solution, and emulsifying uniformly to obtain a medical coating material;

the siloxane resin is trimethylsiloxysilicate, trimethylsiloxysilicate/polypropylsilsesquioxane, acrylate/trimethicone-methacrylate copolymer, trimethylsiloxysilicate/dimethiconol cross-linked polymer;

the viscosity of the volatile siloxane is 0.65mPa.s/25 ℃, and the flash point is lower than-3 ℃.

2. A medical coating material according to claim 1, wherein said water-soluble chitosan is: hyaluronic acid-like chitosan, carboxymethyl chitosan, hydroxypropyl trimethyl ammonium chloride chitosan, chitosan lactate, chitosan hydrochloride, chitosan acetate or chitosan oligosaccharide.

3. A medical coating material according to claim 1, wherein said emulsifier is: a water-in-oil emulsifier or a mixed emulsifier of a water-in-oil emulsifier and an oil-in-water emulsifier.

4. A medical coating material according to claim 3, wherein the oil-in-water type emulsifier is used in an amount of 1 to 100 parts by mass.

5. A medical coating material according to claim 1, wherein the emulsification is high speed homogeneous emulsification, mechanical agitation emulsification or grinding emulsification.