CN107898659A

CN107898659A - Co-Q10 freezes sudden strain of a muscle and releases piece and preparation method thereof

Info

Publication number: CN107898659A
Application number: CN201711459606.1A
Authority: CN
Inventors: 孙冬梅; 周川云; 李宏; 于自勋; 王晓玲
Original assignee: Zhejiang Daimeidiya Cosmetics Co Ltd
Current assignee: Zhejiang Daimeidiya Cosmetics Co Ltd
Priority date: 2017-12-28
Filing date: 2017-12-28
Publication date: 2018-04-13

Abstract

The present invention relates to cosmetic technical field, more particularly to Co-Q10 to freeze sudden strain of a muscle and release piece, includes the raw material of following weight fraction：0.1~5 part of Co-Q10,0.1~5 part of tocopherol acetate, 0.1~5 part of food grade emulsifier, 5~10 parts of freeze drying protectant, 8 0.01~10 parts of acetyl group hexapeptide, 0.01~10 part of resveratrol.The Co-Q10 of the present invention freezes sudden strain of a muscle and releases piece and use high-pressure homogeneous nanoscale science and technology, hypothermic lyophilization technology, and double three high-end science and technology perfect adaptations of aluminium nitrogen-filled seal technology, make Co-Q10 particulate stability more preferably, active higher, permeability it is more preferable, so as to increase substantially absorption of the skin to Co-Q10, reach preferable skin effect.

Description

Co-Q10 freezes sudden strain of a muscle and releases piece and preparation method thereof

Technical field

The present invention relates to cosmetic technical field, more particularly to Co-Q10 to freeze sudden strain of a muscle and release piece and preparation method thereof.

Background technology

With the sound development of Chinese society economy, the service life of China mankind constantly extends, and has stepped into old-age group Change society, anti-aging, beauty skin care product have been to be concerned by more and more people, and the skin of human health is wetting, softness, has Elasticity and gloss, have natural defencive function, can resist injury of the environment such as dust storm, cold, drying to skin, skin keratin In layer, containing 10~20% moisture, its source is mainly the sweat of sweat gland secretion, to keep the plasticity of horny layer of epidermis, soft It is soft smooth, maintain the moistening and elasticity of skin.But there are some researches prove the skin of the mankind will be with the age after 25 years old Increase and gradual aging, the detailed damped exponential model of comparison just occurs later about at 35 years old, at this time, into fiber in human skin The quantity of cell gradually decreases, its collagen secreted and elastic fibers albumen are right also because being gradually decreased, being broken by oxidation The supporting role of epidermis just disappears, skin corium start it is thinning, skin elasticity be deteriorated, therefore cause it is inhomogenous collapse, produce Wrinkle, wrinkle and skin metabolism hypofunction, blood supply are reduced, and sebum secretion reduces closely related, causes skin It is dry, thinning；In addition, the skin of aging also has elastic fibers and collagenous fibres reduction, the thicker, aging of skin corium, skin bullet Property lower, show the elderly's skin texture change feature：It is dry, coarse, corrugate, loose and benign or malignant neoplasm Incidence increase.

The wrinkle resistant aging products of moisturizing emerge in an endless stream currently on the market, and not only effect is unsatisfactory for these cosmetics, can only Absorbed by skin surface, but also skin is easily injured containing a large amount of irritating chemical substances, long-time service.

Co-Q10 is a kind of fat-soluble antioxidant, its content on mitochondrial inner membrane be significantly larger than respiratory chain other The content of component, because its fat-soluble feature makes it have very high mobility on mitochondrial inner membrane, so that it is particularly It is suitable as a kind of mobility electron transit mediator.Co-Q10 mainly has two effects in vivo, first, in the online grain of nutriment Conversion in the body be energy during play an important role, second, there is obvious lipoid peroxidization resistant.It is cell line grain Energy conversion agent in body, it participates in " tricarboxylic acid cycle " generation ATP (atriphos) by shifting and transmitting electronics, can The factor is measured to use for cell metabolism.All show in most cells in human body there are Co-Q10 through numerous studies and report, Appropriate supplement Co-Q10 can improve cell viability from root, promote body actively to carry out self-regeneration and adjustment, lifting Cellular energy levels, improve the immunity of the human body, strengthen it is anti-oxidant, confrontation radical damage, anti-aging, enhancing human activity, Antitumor, the protection function such as skin and heart.Painstaking effort systemic disease is medically widely used in, uses it for nutrition extensively both at home and abroad Health products and food additives, service stage at initial stage is still in cosmetic field.

For people at 20 years old, the Co-Q10 ability independently synthesized reached peak, can decline year by year later, maintained to 50 years old left side It is right.Because the cell mitochondrial DNA material of deposit Co-Q10 is destroyed by oxygen radical, autonomous synthesizing coenzyme Q 10 is caused to reduce, As a result decline the metabolic function of human body cell, " senile " just displays.The increase of wrinkle, the aging of skin with it is auxiliary Enzyme Q10 contents are related, and content is lower, and skin is more easy to aging, and wrinkle is also more.Co-Q10 can be absorbed by taking orally；This Outside, the skin care item containing Co-Q10 can also be embrocated, being embrocated by external application more can targetedly increase aged skin cells pair The absorption of Co-Q10, gos deep into skin cell by stratum corneum barrier, strengthens cell metabolism function, consolidation between Polygonum Multiflorum Thunb Extract Binding ability, in the net structure of skin corium shape glue elasticity, repairs the skin elasticity caused by Co-Q10 loses and declines really, So as to reduce the formation of wrinkle.

In existing technology, the more of cream emulsion is made in Co-Q10.Co-Q10 hydrophobicity is strong, average molecular matter Measure larger, it is very sensitive to light, its active rapid decrease in the state of illumination, until losing activity and its distinctive work( Effect.Therefore, the active material in cream emulsion containing Co-Q10 is influenced by moisture, oxygen, light etc., and perishable, oxidation, grow Microorganism, particularly Co-Q10 inevitably meet light in use is opened, cause the degraded of Co-Q10 component, cause to live Property decline, do not reach expected skin effect.

The content of the invention

In view of this, freeze sudden strain of a muscle the object of the present invention is to provide Co-Q10 and release piece and preparation method thereof, use is high-pressure homogeneous Nanoscale science and technology, hypothermic lyophilization technology, and double three high-end science and technology perfect adaptations of aluminium nitrogen-filled seal technology makes auxiliary Enzyme Q10 particulates stability more preferably, active higher, permeability it is more preferable, so as to increase substantially absorption of the skin to Co-Q10, reach To preferable skin effect.

The present invention solves above-mentioned technical problem by following technological means：

Co-Q10 freezes sudden strain of a muscle and releases piece, and the lyophilized sudden strain of a muscle is released piece and is sealed in nitrogen charging aluminium film, the lyophilized sudden strain of a muscle release piece include with The raw material of lower weight fraction：0.1~5 part of Co-Q10,0.1~5 part of tocopherol acetate, 0.1~5 part of food grade emulsifier, jelly Dry 5~10 parts of protective agent, 0.01~10 part of Argireline, 0.01~10 part of resveratrol.

The Co-Q10 of the present invention freeze dodge release piece emulsifier it is smaller, and use food grade emulsifier, do not add it Its chemical stimulation auxiliary material, avoids causing skin the adverse effects such as stimulation；The formulation of the present invention is that piece is released in lyophilized sudden strain of a muscle, and is sealed In that in nitrogen charging aluminium film, can protect Co-Q10 from the influence of the undesirable element such as light, moisture, oxygen in environment well, grow Kubo holds the concentration and activity of Co-Q10.In use, piece is released in lyophilized sudden strain of a muscle releases instant, quick release Co-Q10 with specified solvent sudden strain of a muscle High concentration active ingredient, makes Co-Q10 particle dispersibility more preferably, and osmotic absorption effect is stronger, reaches preferable skin effect.

Based on the above technical solutions, the present invention can also be improved as follows：

Further, piece is released in the lyophilized sudden strain of a muscle includes 1.5 parts of food grade emulsifier.

Further, the food grade emulsifier is egg yolk lecithin or soybean lecithin.Egg yolk lecithin and soybean lecithin are equal With stronger emulsification, wetting, peptizaiton.

Further, the freeze drying protectant is one kind in mannitol, trehalose, PVP K30.Mannitol, seaweed Sugar, PVP K30 are gentle, the safe and non-stimulating freeze drying protectants of Nature comparison.

The preparation method for releasing piece is dodged in addition, being freezed the invention also discloses above-mentioned Co-Q10, is comprised the following steps：

High-pressure homogeneous emulsification process, takes Co-Q10 to be mixed with tocopherol acetate, and oil phase is made, stand-by；Take frozen-dried protective Agent and Argireline, resveratrol mix, and water phase is made, food grade emulsifier is added in water phase, in temperature 50~ 70 DEG C under nitrogen protective effect, are sheared to being uniformly dispersed, and are slow added into oil phase and are continued shearing colostrum is made, by colostrum in temperature Gradient boost is carried out at 40~65 DEG C of degree, it is high-pressure homogeneous to obtain nano suspending liquid.

Frozen drying process, nano suspending liquid is filled in aluminium film, is placed on freeze dryer flaggy, start, into Row low-temperature quick-freezing, gradient increased temperature, vacuum drying, insulation, outlet operation, obtain lyophilized sudden strain of a muscle and release piece.

Double aluminium nitrogen-filled seal processes, release piece under nitrogen filled protection by lyophilized sudden strain of a muscle, carry out aluminium-plastic sealing packaging.

The Co-Q10 of the present invention, which freezes sudden strain of a muscle, to be released piece and uses high-pressure homogeneous nanoscale science and technology, hypothermic lyophilization technology, And double three high-end science and technology perfect adaptations of aluminium nitrogen-filled seal technology, make Co-Q10 particulate stability more preferably, active higher, ooze Permeability is more preferable, so as to increase substantially absorption of the skin to Co-Q10, reaches preferable skin effect.

Further, the speed of the shearing is 5000~30000rpm, and the time is 5~30min.

Further, the gradient boost is as follows：300~500bar low pressure recycles are first carried out to colostrum to handle 1~5 time, its Purpose is to be crushed the larger particle of particle diameter, prevents from damaging high pressure homogenizer under high pressure；600~1000bar is carried out again Cycle of higher pressure is handled 2~10 times, increases the stability of milk particle, obtains the nanosuspension that milk particle particle diameter is less than 600nm.

Further, the temperature of low-temperature quick-freezing is -80 DEG C~-20 DEG C in the frozen drying process.Flash freezing, can The space structure for keeping micro emulsion to stablize.

Further, the vacuum drying vacuum is 0~50pa, and the vacuum drying includes three phases：Stage one, In 10~30h 0 DEG C is gradually heating to by -80 DEG C；In the stage two, 30 DEG C are gradually heating in 1~10h by 0 DEG C；Stage three, 30 DEG C insulation 3h.

Further, double aluminium nitrogen-filled seal processes are that lyophilized sudden strain of a muscle is released piece in 150~200 DEG C of temperature, nitrogen pressure Aluminium-plastic sealing packaging is carried out under the conditions of 0.01MPa.The lyophilized active ingredient concentration and activity dodged and release piece can be preserved for a long time.

Beneficial effects of the present invention：

The high-end science and technology technology that the present invention is combined using high-pressure homogeneous, frozen drying and double aluminium nitrogen-filled seals, choosing The emulsifying agents that skin-friendly is strong, osmotic effect is excellent such as feeding grade phosphatide, collocation tocopherol acetate cooperate with anti-with Co-Q10 Oxygen, the dispersion that a kind of oil-in-water that Co-Q10 particulate is dispersed in water and is formed is stablized, the components such as Co-Q10 are adopted With gradient boost two-step method, be made the finely dispersed nanometer micro emulsion suspension of good stability, particulate, smaller particle permeability compared with It is good, bioavilability can be improved, its drugloading rate (weight concentration) reaches 10%, then carries out frozen drying, is freezed Piece is released in sudden strain of a muscle, final to carry out double aluminium nitrogen-filled seals, can preserve its concentration and work for a long time in the state of anaerobic, anhydrous, lucifuge Property.In use, lyophilized sudden strain of a muscle is released, piece is instant with specifying solvent sudden strain of a muscle to release, and quick release Co-Q10 high concentration active ingredient, makes coenzyme More preferably, osmotic absorption effect is stronger for Q10 particle dispersibilities, reaches preferable skin effect.

Embodiment

Below with reference to specific embodiment, the present invention is described in detail：

The Co-Q10 of the present invention, which freezes sudden strain of a muscle and releases piece, to be sealed in nitrogen charging aluminium film, includes the raw material of following weight fraction：Coenzyme Q100.1~5 part, 0.1~5 part of tocopherol acetate, 0.1~5 part of food grade emulsifier, 5~10 parts of freeze drying protectant, acetyl Other aqueous phase substances such as -80.01~10 parts of base hexapeptide, 0.01~10 part of resveratrol.Its preparation method is as follows：

High-pressure homogeneous emulsification process, takes Co-Q10 to be mixed with tocopherol acetate, and oil phase is made, stand-by；Take frozen-dried protective Other aqueous phase substances such as agent and Argireline, resveratrol mix, and water phase is made, food grade emulsifier is added to water phase In, in 50~70 DEG C of temperature under nitrogen protective effect, shear to being uniformly dispersed, be slow added into oil phase and continue shearing and be made just Breast, gradient boost is carried out by colostrum at 40~65 DEG C of temperature, high-pressure homogeneous to obtain nano suspending liquid；

Frozen drying process, nano suspending liquid is filled in aluminium film, is placed on freeze dryer flaggy, start, into Row low-temperature quick-freezing, gradient increased temperature, vacuum drying, insulation, outlet operation, obtain lyophilized sudden strain of a muscle and release piece；

Embodiment one

The preparation method that piece is released in the lyophilized sudden strain of a muscle of the present embodiment is as follows：

High-pressure homogeneous emulsification process, takes 0.1 part of Co-Q10 and 0.1 part of tocopherol acetate to mix, oil phase is made, stand-by； Take other aqueous phase substances such as 5 parts of freeze drying protectants, 0.01 part of Argireline, 0.01 part of resveratrol to mix, water phase be made, It is added to using 1.5 parts of egg yolk lecithins as emulsifying agent in water phase, under nitrogen protective effect, in temperature 50 C, speed 5000rpm carries out shearing and is uniformly dispersed, and shear time is 30min, is then slow added into oil phase and continues shearing colostrum is made, will Colostrum first carries out 300~500bar low pressure recycles and handles 1 time under the conditions of 40 DEG C of temperature；600~1000bar high pressures are carried out again Circular treatment 3 times, obtains nanosuspension；

Frozen drying process, nano suspending liquid is filled in aluminium film freeze-dried material, is placed on freeze dryer flaggy, Start, instantaneous temperature reduction to -80 DEG C of progress low-temperature quick-freezings, keeps 4h, and three stage gradient heatings, true are carried out with after vacuum 0pa Sky is dry：In the stage one, 0 DEG C is gradually heating in 30h by -80 DEG C；In the stage two, 30 DEG C are gradually heating in 1h by 0 DEG C；Stage Three, 3h is kept the temperature at 30 DEG C, last outlet operation, obtains lyophilized sudden strain of a muscle and release piece, drugloading rate reaches more than 10%；

Double aluminium nitrogen-filled seal processes, will release the plastic-aluminum piece of piece in 150 DEG C of temperature equipped with lyophilized dodge, nitrogen pressure 0.01MPa's Under the conditions of carry out aluminium-plastic sealing packaging.

Embodiment two

High-pressure homogeneous emulsification process, takes 2 parts of Co-Q10s and 2 parts of tocopherol acetates to mix, oil phase is made, stand-by；Take 7 Part freeze drying protectant, 2 parts of Argirelines, 2 parts of resveratrols mix, and water phase are made, using 1.5 parts of soybean lecithins as emulsification Agent is added in water phase, under nitrogen protective effect, is carried out shearing in temperature 70 C, speed 10000rpm and is uniformly dispersed, shearing Time is 25min, is slow added into oil phase and continues shearing colostrum is made, by colostrum under the conditions of 65 DEG C of temperature, first carry out 300~ 500bar low pressure recycles are handled 3 times, then are carried out 600~800bar cycle of higher pressure and handled 10 times, obtain nanosuspension；

Frozen drying process, nano suspending liquid is filled in aluminium film freeze-dried material, is placed on freeze dryer flaggy, Start, instantaneous temperature reduction to -80 DEG C progress low-temperature quick-freezings, keep 10h, with after vacuum 20pa carry out three stage gradient heatings, Vacuum drying：In the stage one, 0 DEG C is gradually heating in 20h by -80 DEG C；In the stage two, 30 DEG C are gradually heating in 5h by 0 DEG C； In the stage three, 3h is kept the temperature at 30 DEG C, last outlet operation, obtains lyophilized sudden strain of a muscle and release piece, drugloading rate reaches more than 10%；

Embodiment three

In the present embodiment by the egg yolk lecithin in embodiment one replace with egg yolk lecithin with it is chitosan crosslinked compound Microballoon, chitosan have antibacterial and bacteriostasis, while using inclusion property, absorption property and the cross-linking properties of chitosan, can It is effectively compound with egg yolk lecithin, the effect of playing its antibiotic skin-care jointly.Its preparation is as follows：In mass ratio 1:2, which weigh shell, gathers Sugar and egg yolk lecithin, dissolve the chitosan in the acetic acid solution that mass fraction is 1%, stirring, and it is solidifying to treat that fully dissolving is formed After glue, stand 2h and remove bubble, obtain the chitosan solution that mass concentration is 1.5%；It is with syringe that egg yolk lecithin is molten Liquid is injected into chitosan solution, is stirred and evenly mixed, and is instilled the glutaraldehyde water solution that mass fraction is 25% and is stirred 2h, is obtained by filtration Solid remove remaining glutaraldehyde with the phosphate buffer of 0.1mol/L immersion 5h, filtering, be dried to obtain egg yolk lecithin/ Chitosan compound microsphere.

High-pressure homogeneous emulsification process, takes 4 parts of Co-Q10s and 4 parts of tocopherol acetates to mix, oil phase is made, stand-by；Take 8 Part freeze drying protectant, 6 parts of Argirelines, 6 parts of resveratrols mix, and water phase are made, using 0.1 part of egg yolk lecithin as breast Agent is added in water phase, under nitrogen protective effect, is carried out shearing in temperature 60 C, speed 20000rpm and is uniformly dispersed, cut It is 15min to cut the time, is slow added into oil phase and continues shearing colostrum is made, and by colostrum under the conditions of temperature 50 C, first carries out 300 ~500bar low pressure recycles are handled 5 times；600~800bar cycle of higher pressure is carried out again to handle 10 times, obtains nanosuspension；

Frozen drying process, nano suspending liquid is filled in aluminium film freeze-dried material, is placed on freeze dryer flaggy, Start, instantaneous temperature reduction to -80 DEG C of progress low-temperature quick-freezings, keeps 8h, and three stage gradient heatings, true are carried out with after vacuum 40pa Sky is dry：In the stage one, 0 DEG C is gradually heating in 30h by -80 DEG C；In the stage two, 30 DEG C are gradually heating in 10h by 0 DEG C； In the stage three, 3h is kept the temperature at 30 DEG C, last outlet operation, obtains lyophilized sudden strain of a muscle and release piece, drugloading rate reaches more than 10%；

Double aluminium nitrogen-filled seal processes, will release the plastic-aluminum piece of piece in 180 DEG C of temperature equipped with lyophilized dodge, nitrogen pressure 0.01MPa's Under the conditions of carry out aluminium-plastic sealing packaging.

Example IV

The soybean lecithin in embodiment two is replaced with into soybean lecithin and chitosan crosslinked complex microsphere in the present embodiment, Its preparation is as follows：In mass ratio 1:1.5 weigh chitosan and soybean lecithin, dissolve the chitosan in the second that mass fraction is 1% In acid solution, stirring, after abundant dissolving forms coagulant liquid, stands 2h and removes bubble, obtains the shell that mass concentration is 1.5% and gathers Sugar juice；Soybean lecithin solution is injected into chitosan solution with syringe, is stirred and evenly mixed, it is 25% to instill mass fraction Glutaraldehyde water solution stirs 2h, and the solid being obtained by filtration removes remaining penta 2 with the phosphate buffer immersion 5h of 0.1mol/L Aldehyde, filtering, is dried to obtain soybean lecithin/chitosan compound microsphere.

High-pressure homogeneous emulsification process, takes 5 parts of Co-Q10s and 5 parts of tocopherol acetates to mix, oil phase is made, stand-by；Take 10 Part freeze drying protectant, 10 parts of Argirelines, 10 parts of resveratrols mix, and water phase are made, using 5 parts of soybean lecithins as emulsification Agent is added in water phase, under nitrogen protective effect, is carried out shearing in temperature 60 C, speed 30000rpm and is uniformly dispersed, shearing Time is 5min, is slow added into oil phase and continues shearing colostrum is made, by colostrum under the conditions of temperature 50 C, first carry out 300~ 500bar low pressure recycles are handled 2 times；600~800bar cycle of higher pressure is carried out again to handle 2 times, obtains nanosuspension；

Frozen drying process, nano suspending liquid is filled in aluminium film freeze-dried material, is placed on freeze dryer flaggy, Start, instantaneous temperature reduction to -20 DEG C of progress low-temperature quick-freezings, keeps 8h, and three stage gradient heatings, true are carried out with after vacuum 50pa Sky is dry：In the stage one, 0 DEG C is gradually heating in 10h by -20 DEG C；In the stage two, 30 DEG C are gradually heating in 10h by 0 DEG C； In the stage three, 3h is kept the temperature at 30 DEG C, last outlet operation, obtains lyophilized sudden strain of a muscle and release piece, drugloading rate reaches more than 10%；

Double aluminium nitrogen-filled seal processes, will release the plastic-aluminum piece of piece in 200 DEG C of temperature equipped with lyophilized dodge, nitrogen pressure 0.01MPa's Under the conditions of carry out aluminium-plastic sealing packaging.

Piece is released into the lyophilized sudden strain of a muscle that embodiment one and embodiment two are prepared and carries out pH value detection and droplet measurement, as a result such as Table 1：

1 different emulsifiers of table, which are made Co-Q10 and freeze sudden strain of a muscle, releases piece micro emulsion pH value and particle diameter

The data of table 1, which are shown, to be pointed out, the present invention is handled the larger particle of particle diameter by two step shear granulations, low pressure recycle Crushed, prevent from damaging high pressure homogenizer under high pressure, cycle of higher pressure increases the stability of milk particle, obtains milk particle particle diameter and is less than The nanosuspension of 600nm, and pH=5.4~6.4, property is gentle, and stimulate the reaction will not be produced to skin.

Piece and the cream on the market containing Co-Q10 are released in the lyophilized sudden strain of a muscle that Example two is prepared, and are not being shared the same light According to finished product content detection is carried out under the time, as a result such as table 2：

Finished product content change of the different light application times of table 2 containing Co-Q10

By the data of table 2 show it can be seen under illumination condition, the Co-Q10 in piece is released in lyophilized sudden strain of a muscle prepared by the present invention Relative to cream on the market, its activity can be kept for a long time, not easy in inactivation.

After the volunteer selected at random carries out measure of merit, it is found that freezing sudden strain of a muscle using the Co-Q10 of the present invention releases piece After one month, skin moisture increased, pore, wrinkle, roughness, acne have clear improvement, as shown in table 3.

Table 3 uses front and rear Contrast on effect

By the data of table 3 show it can be seen from the lyophilized sudden strain of a muscle for preparing of the present invention to release piece osmotic absorption effect preferable, can promote Absorption into skin to Co-Q10, carries out moisturizing to human skin, reduces pore, reduce skin roughness, can effectively resist Decline, increase skin water humidity, glossiness.

The above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, although with reference to preferred embodiment to this hair It is bright to be described in detail, it will be understood by those of ordinary skill in the art that, it can modify to technical scheme Or equivalent substitution, without departing from the objective and scope of technical solution of the present invention, it should all cover the claim in the present invention Among scope.The present invention be not described in detail technology, shape, construction part be known technology.

Claims

1. Co-Q10 freezes sudden strain of a muscle and releases piece, it is characterised in that the lyophilized sudden strain of a muscle is released piece and is sealed in nitrogen charging aluminium film, the lyophilized sudden strain of a muscle Releasing piece includes the raw material of following weight fraction：0.1~5 part of Co-Q10,0.1~5 part of tocopherol acetate, food grade emulsifier 0.1~5 part, 5~10 parts of freeze drying protectant, 0.01~10 part of Argireline, 0.01~10 part of resveratrol.

2. Co-Q10 according to claim 1 freezes sudden strain of a muscle and releases piece, it is characterised in that piece is released in the lyophilized sudden strain of a muscle includes food 1.5 parts of grade emulsifying agent.

3. Co-Q10 according to claim 2 freezes sudden strain of a muscle and releases piece, it is characterised in that the food grade emulsifier is yolk Lecithin or soybean lecithin.

4. Co-Q10 according to claim 3 freezes sudden strain of a muscle and releases piece, it is characterised in that the freeze drying protectant is mannose One kind in alcohol, trehalose, PVPK30.

5. the Co-Q10 according to any of the above-described claim, which freezes to dodge, releases the preparation method of piece, it is characterised in that including with Lower step：

High-pressure homogeneous emulsification process, takes Co-Q10 to be mixed with tocopherol acetate, and oil phase is made, stand-by；Take freeze drying protectant with Argireline, resveratrol mix, and water phase is made, food grade emulsifier is added in water phase, in 50~70 DEG C of temperature Under nitrogen protective effect, shear to being uniformly dispersed, be slow added into oil phase and continue shearing colostrum is made, by colostrum in temperature 40 Gradient boost is carried out at~65 DEG C, it is high-pressure homogeneous to obtain nano suspending liquid；

Frozen drying process, nano suspending liquid is filled in aluminium film, is placed on freeze dryer flaggy, and start, carries out low Warm quick-frozen, gradient increased temperature, vacuum drying, insulation, outlet operation, obtain lyophilized sudden strain of a muscle and release piece；

6. Co-Q10 according to claim 5 freezes the preparation method dodged and release piece, it is characterised in that the speed of the shearing Degree is 5000~30000rpm, and the time is 5~30min.

7. Co-Q10 according to claim 6 freezes the preparation method dodged and release piece, it is characterised in that the gradient boost It is as follows：300~500bar low pressure recycles are first carried out to colostrum to handle 1~5 time, then carry out the processing of 600~1000bar cycle of higher pressure 2~10 times.

8. Co-Q10 according to claim 7 freezes the preparation method dodged and release piece, it is characterised in that the cryogenic freezing The temperature of low-temperature quick-freezing is -80 DEG C~-20 DEG C in drying process.

9. Co-Q10 according to claim 8 freezes the preparation method dodged and release piece, it is characterised in that the vacuum drying Vacuum be 0~50pa, the vacuum drying includes three phases：In the stage one, 0 is gradually heating in 10~30h by -80 DEG C ℃；In the stage two, 30 DEG C are gradually heating in 1~10h by 0 DEG C；In the stage three, 3h is kept the temperature at 30 DEG C.

10. Co-Q10 according to claim 9 freezes the preparation method dodged and release piece, it is characterised in that double aluminium nitrogen charging Sealing process is that the plastic-aluminum piece for releasing piece equipped with lyophilized sudden strain of a muscle is carried out aluminium under the conditions of 150~200 DEG C of temperature, nitrogen pressure 0.01MPa Modeling packs.